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Idiopathic scoliosis

Yu-Lin Li, Shi-Jie Gao, Hong Xu, Yang Liu, Hai-Liang Li, Xing-Yu Chen, Guang-Zhi Ning, Shi-Qing Feng
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common structural deformity of the spine. Genetics constitute largely to AIS, and the rs11190870 polymorphism has the potential for use in public health and clinical settings as a predictor of AIS risk. The aim of the present meta-analysis was to provide exhaustive evidence to evaluate the association of rs11190870 with the susceptibility and severity of adolescent idiopathic scoliosis (AIS) in multiple ethnic groups and different genders...
March 10, 2018: International Journal of Surgery
Bin Sheng, Youchao Yuan, Xiangyang Liu, Yi Zhang, Hongzhe Liu, Xiongjie Shen, Bin Liu, Lei Chang
Dysfunction of cartilaginous endplates (CEP) is an important etiologic aspect of intervertebral disc degeneration (IDD) because the endplate has nutritional and biomechanical functions in maintaining proper disc health. In this study, we investigated the regulatory effects of estrogen on degenerated human CEP cells and the involvement of miR-221 in these effects. Normal and degenerated human CEP tissues were collected from patients with idiopathic scoliosis and IDD, respectively. CEP cells were isolated from these tissues...
February 26, 2018: Acta Biochimica et Biophysica Sinica
Hideki Sudo, Yuichiro Abe, Terufumi Kokabu, Kei Kuroki, Akira Iwata, Norimasa Iwasaki
STUDY DESIGN: Prospective, non-randomized study. OBJECTIVE: To assess surgical outcomes of multilevel facetectomy and rod curvature with simultaneous double-rod rotation technique for anatomical spinal reconstruction in thoracic adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Although some surgical techniques maintain or restore thoracic kyphosis (TK), next-generation strategies for thoracic AIS should include corrections in three anatomical planes...
March 9, 2018: Spine
Jun Qiao, Lingyan Xiao, Leilei Xu, Bangping Qian, Zezhang Zhu, Yong Qiu
STUDY DESIGN: This is a genetic association study. OBJECTIVE: To investigate association between suppressor of cytokine signaling-3 (SOCS3) gene polymorphisms and the onset and progression of lumbar adolescent idiopathic scoliosis (AIS) and to further clarify its role in the regulation of SOCS3 expression in AIS patients. SUMMARY OF BACKGROUND DATA: Some studies showed that muscle development imbalance may be responsible for onset and progression of lumbar AIS...
March 9, 2018: Clinical Spine Surgery
Mahdieh Khodaei, Doug Hill, Rui Zheng, Lawrence H Le, Edmond H M Lou
PURPOSE: This study aimed to determine the intra- and inter-rater reliabilities of spinal flexibility measurements using ultrasound imaging on non-surgical candidates with adolescent idiopathic scoliosis (AIS). METHODS: Twenty-eight consecutive consented AIS subjects (25 F; 3 M) were recruited; 24 subjects' data were used for analysis. This study explored curve magnitude differences between standing, prone and voluntary maximum side-bending postures to assess the reliability of spinal flexibility (SF)...
March 9, 2018: European Spine Journal
Angelo G Aulisa, Vincenzo Guzzanti, Francesco Falciglia, Marco Giordano, Marco Galli, Lorenzo Aulisa
BACKGROUND: The recent literature showed positive results for bracing of patients with idiopathic scoliosis above 45° who refused surgery. However, no one has investigated whether other parameters can affect the results. AIM: The aim of this study was to evaluate the effectiveness of bracing in idiopathic scoliosis with curves above 40° and to verify the mechanical and biological parameters which go beyond the simple bend value expressed in Cobb degrees. DESIGN: This is an observational controlled cohort study nested in a prospective clinical on-going database including 1,238 patients with idiopathic scoliosis...
March 7, 2018: European Journal of Physical and Rehabilitation Medicine
Shunan Liu, Yuancheng Zhang, Hongda Bao, Peng Yan, Zezhang Zhu, Zhen Liu, Bangping Qian, Yong Qiu
BACKGROUND: A proper restoration of sagittal alignment is essential in AIS patients, but few studies provided a formula to predict an optimal surgical thoracic kyphosis (TK) gain in adolescent idiopathic scoliosis (AIS) patients. A formula was recently proposed (LL = (PI+TK)/2 + 10) to predict the optimal lumbar lordosis (LL) in adult spinal deformity patients, which has not been validated in adolescents. The aim of this study is to establish a formula with TK and pelvic parameters in normal adolescents and predict an optimal TK with this formula pre- and post-operatively in Lenke 1 AIS patients...
March 7, 2018: BMC Musculoskeletal Disorders
Kimberly J Song, Matthew Colman, Jonathan A Myers, Christopher W Seder
Adolescent idiopathic scoliosis may require surgical treatment for extreme curvature of the spine or loss of pulmonary function. We present a report of a 31-year-old woman with a history of scoliosis and anterolateral spinal fusion who developed chest pain and hemoptysis. Imaging revealed that a fixation rod had migrated cephalad, penetrating the diaphragm into the left lower lobe of the lung. The hardware was removed and lung repaired with good results. This is the first reported case of cranial spinal rod migration over a decade after initial implantation...
March 5, 2018: Lung
Turgut Akgül, Kerim Sarıyılmaz, Murat Korkmaz, Okan Özkunt, Özcan Kaya, Fatih Dikici
Study Design: Retrospective analysis of adolescent idiopathic scoliosis. Purpose: This study aimed to investigate the influence of distinct distal fusion levels on spinopelvic parameters in patients with adolescent idiopathic scoliosis (AIS) who underwent posterior instrumentation and fusion surgery. Overview of Literature: The distal fusion level selection in treatment of AIS is the one of milestone to effect on surgical outcome. Most of the paper focused on the coronal deformity correction and balance...
February 2018: Asian Spine Journal
Matthew E Oetgen
Evidence-based medicine (EBM) is a process of decision-making aimed at making the best clinical decisions as they relate to patients' health. The current use of EBM in pediatric spine surgery is varied, based mainly on the availability of high-quality data. The use of EBM is limited in idiopathic scoliosis, whereas EBM has been used to investigate the treatment of pediatric spondylolysis. Studies on early onset scoliosis are of low quality, making EBM difficult in this condition. Future focus and commitment to study quality in pediatric spinal surgery will likely increase the role of EBM in these conditions...
April 2018: Orthopedic Clinics of North America
Jérémy Allia, Jean-Luc Clément, Virginie Rampal, Béatrice Leloutre, Olivier Rosello, Federico Solla
STUDY DESIGN: Monocentric study comparing results of simultaneous translation on 2 rods (ST2R) with derotation connectors (prospective series) or without derotation connectors (retrospective series) in Adolescent Idiopathic Scoliosis (AIS) surgery. OBJECTIVE: The objective of this study was to assess if derotation connectors influence axial, coronal, and sagittal results in AIS surgery. SUMMARY OF BACKGROUND DATA: Conventional reduction techniques remain limited in their ability to reduce axial torsion...
February 28, 2018: Clinical Spine Surgery
Francesca Di Felice, Fabio Zaina, Sabrina Donzelli, Stefano Negrini
OBJECTIVE: To provide a meta-analysis of current literature concerning the natural history of idiopathic scoliosis during growth. DESIGN: A comprehensive search of MEDLINE, EMBASE, and SCOPUS databases was conducted up to November 2016. Eligible works were prospective or retrospective studies that enrolled patients with infantile (IIS), juvenile (JIS), or adolescent idiopathic scoliosis (AIS), followed up without any treatment from the time of detection. A meta-analysis for proportion was performed...
November 9, 2017: American Journal of Physical Medicine & Rehabilitation
Xin Yin, Huadong Wang, Jidong Guo, Liang Zhang, Yupeng Zhang, Li Li, Shuxun Hou
BACKGROUND: AIS is the most common spinal deformity disease, yet its etiology remains uncertain. Significant associations have been found between AIS risk and vitamin D receptor (VDR) gene polymorphisms; however, some of these results are controversial. The aim of this study was to determine whether VDR BsmI rs1544410 and ApaI rs7975232 polymorphisms are correlated with AIS. METHODS: Databases, including PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database, were systematically searched, and eligible case-control studies that explored the association of VDR (BsmI and ApaI) and the susceptibility to AIS were selected...
January 2018: Medicine (Baltimore)
Kerim Sariyilmaz, Okan Ozkunt, Gokhan Karademir, Halil Can Gemalmaz, Fatih Dikici, Unsal Domanic
The aim of this study is to compare the effects of high versus low implant density on correction in Lenke type 5 adolescent idiopathic scoliosis (AIS) patients. A retrospective study of 59 Lenke type 5 AIS patients treated at a single institution were divided into to 2 groups according to implant density. Implant density, preoperative, early postoperative, and last follow-up thoracolumbar/lumbar (TL/L) curves were measured. Thirty-one constructs were high and 28 constructs were low density. The groups were similar in terms of age, sex, Cobb angle, and follow-up time...
January 2018: Medicine (Baltimore)
Yanming Li, Changwei Yang, Xiaodong Zhu, Ming Li
A retrospective study.The optimal implant density in patients with Lenke type 1 adolescent idiopathic scoliosis (AIS) is undefined, and there is no study reporting the correlation between the partitional implant density and the correction outcome.To determine whether the implant density in structural and nonstructural regions would affect the coronal correction outcome of Lenke 1A and 1B AIS.Preoperative general data and postoperative follow-up data of Lenke 1A and 1B AIS patients who received posterior fusion with the pedicle screw system were analyzed...
January 2018: Medicine (Baltimore)
Shoji Seki, Yasuhito Yahara, Hiroto Makino, Yoshiharu Kawaguchi, Tomoatsu Kimura
BACKGROUND: Ponte osteotomy is a useful method in posterior spinal release. However, it is unclear whether Ponte osteotomy itself contributes to vertebral derotation in surgery for adolescent idiopathic scoliosis (AIS) patients compared to inferior facetectomy alone. This study aimed to assess the effect of Ponte osteotomy on the magnitude of periapical vertebral body rotation compared to inferior facetectomy alone. This study was a prospective collected data. METHODS: The study included 63 patients with AIS (Thoracic curve type, 35; thoracolumbar/lumbar curve type, 27), who underwent surgery between August 2011 and January 2015...
February 22, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Ewa Misterska, Jakub Głowacki, Maciej Głowacki, Adam Okręt
We aimed to provide a complex assessment of adult females with adolescent idiopathic scoliosis (AIS) after a minimum of 23 years after completed Milwaukee brace treatment. In the present study, a comparison between healthy female and AIS patients' perception of trunk disfigurement, self-image, mental health, pain level and everyday activity was made. Thirty AIS patients with a mean of 27.77 yrs (SD 3.30) after the treatment were included in the study. The control group consisted of 42 females, matching the age profile of the patient group...
2018: PloS One
Michael Faloon, Nikhil Sahai, Todd P Pierce, Conor J Dunn, Kumar Sinha, Ki Soo Hwang, Arash Emami
BACKGROUND: Several studies have sought to address the role of routine preoperative MRI in patients with adolescent idiopathic scoliosis (AIS) undergoing deformity correction. Despite similar results regarding the prevalence of neuraxial anomalies detected on MRI, published conclusions conflict and give opposing recommendations. Lack of consensus has led to important variations in use of MRI before spinal surgery for patients with AIS. QUESTIONS/PURPOSES: This systematic review and meta-analysis of studies about patients with AIS evaluated (1) the overall proportion of neuraxial abnormalities; (2) the patient factors and curve characteristics that may be associated with abnormalities; and (3) the proportion of patients who underwent neurosurgical intervention before scoliosis surgery and the kinds of neuraxial lesions that were identified...
February 21, 2018: Clinical Orthopaedics and related Research
Yetian Li, Fei Sheng, Chao Xia, Leilei Xu, Yong Qiu, Zezhang Zhu
STUDY DESIGN: A retrospective study. OBJECTIVES: To investigate the severity of pulmonary function impairment for AMC patients with concomitant scoliosis and to determine risk factors associated with the impaired pulmonary function in these patients.Summary of Background Data Arthrogryposis multiplex congenital (AMC) patients are generally believed to have impaired pulmonary function. However, the severity of respiratory morbidity and the associated risk factors have not been reported...
February 16, 2018: Spine
Jamal N Shillingford, Joseph L Laratta, Lee A Tan, Nana O Sarpong, James D Lin, Charla R Fischer, Ronald A Lehman, Yongjung J Kim, Lawrence G Lenke
BACKGROUND: Spinopelvic fixation is an integral part of achieving solid fusion across the lumbosacral junction, especially in deformity procedures requiring substantial correction or long-segment constructs. Traditional S2-alar-iliac (S2AI) screw-placement techniques utilize fluoroscopy, increasing operative time and radiation exposure to the patient and surgeon. We describe a novel free-hand technique for S2AI screw placement in patients with adult spinal deformity. METHODS: We reviewed the records of 45 consecutive patients who underwent spinopelvic fixation performed with use of S2AI screws by the senior surgeon and various fellows or residents over a 12-month period (2015 to 2016)...
February 21, 2018: Journal of Bone and Joint Surgery. American Volume
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