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https://www.readbyqxmd.com/read/22703775/alterations-in-maternal-fetal-cellular-trafficking-after-fetal-surgery
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Payam Saadai, Tzong-Hae Lee, Geoanna Bautista, Kelly D Gonzales, Amar Nijagal, Michael P Busch, Chong Jai Kim, Roberto Romero, Hanmin Lee, Shinjiro Hirose, Larry Rand, Douglas Miniati, Diana L Farmer, Tippi C MacKenzie
BACKGROUND/PURPOSE: Bidirectional trafficking of cells between the mother and the fetus is routine in pregnancy and a component of maternal-fetal tolerance. Changes in fetal-to-maternal cellular trafficking have been reported in prenatal complications, but maternal-to-fetal trafficking has never been studied in the context of fetal intervention. We hypothesized that patients undergoing open fetal surgery would have altered maternal-fetal cellular trafficking. METHODS: Cellular trafficking was analyzed in patients with myelomeningocele (MMC) who underwent open fetal surgical repair (n = 5), patients with MMC who had routine postnatal repair (n = 6), and healthy control healthy patients (n = 9)...
June 2012: Journal of Pediatric Surgery
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