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https://www.readbyqxmd.com/read/29050391/psychogenic-amnesia-syndromes-outcome-and-patterns-of-retrograde-amnesia
#1
Neil A Harrison, Kate Johnston, Federica Corno, Sarah J Casey, Kimberley Friedner, Kate Humphreys, Eli J Jaldow, Mervi Pitkanen, Michael D Kopelman
There are very few case series of patients with acute psychogenic memory loss (also known as dissociative/functional amnesia), and still fewer studies of outcome, or comparisons with neurological memory-disordered patients. Consequently, the literature on psychogenic amnesia is somewhat fragmented and offers little prognostic value for individual patients. In the present study, we reviewed the case records and neuropsychological findings in 53 psychogenic amnesia cases (ratio of 3:1, males:females), in comparison with 21 consecutively recruited neurological memory-disordered patients and 14 healthy control subjects...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29048606/contact-location-and-neuropsychological-outcomes-in-subthalamic-deep-brain-stimulation
#2
Darlene P Floden, Caio M Matias, Connor A Wathen, Grace E Ozinga, Olivia Hogue, Andre G Machado
BACKGROUND: A host of influences contribute to cognitive and behavioral changes following deep brain stimulation. The location of the active cathode is likely an important variable but it has received little attention. OBJECTIVE: To determine whether active contact location relative to the subthalamic nucleus and other neighboring structures is related to nonmotor outcomes. METHODS: We identified a retrospective, cross-sectional sample of 46 patients who underwent subthalamic nucleus deep brain stimulation for treatment of idiopathic Parkinson's disease...
October 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29048602/neural-substrates-underlying-the-effects-of-oxytocin-a-quantitative-meta-analysis-of-pharmaco-imaging-studies
#3
Danyang Wang, Xinyuan Yan, Ming Li, Yina Ma
The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of functional-MRI studies intranasally administering OT (IN-OT) to uncover neural substrates underlying the IN-OT effects and to elucidate differential IN-OT effects between healthy and clinical populations. Meta-analyses were conducted on 66 IN-OT fMRI studies, stratified by psychopathology, valence and sex. IN-OT increased bilateral amygdala, caudate head, and superior temporal activity in healthy individuals and increased dorsal anterior cingulate activity in patients...
October 1, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29047377/cognitive-impairment-profile-in-adult-patients-with-niemann-pick-type-c-disease
#4
Camille Heitz, Stéphane Epelbaum, Yann Nadjar
BACKGROUND: Cognitive impairment is one of the core symptoms of Niemann Pick type C (NPC) disease, but few data concerning the neuropsychological profile of NPC patients are available. The aim of our study was to characterize cognitive impairments in NPC disease and to assess the evolution of these symptoms and the impact of miglustat on cognitive follow-up. METHODS: We conducted a retrospective study of 21 adult patients diagnosed with NPC disease. Neuropsychological data (global cognitive efficiency, language, attention, executive functions, praxis, and visuoconstructive functions tests) were retrieved to describe the cognitive profile of patients...
October 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29046879/impaired-synaptic-function-is-linked-to-cognition-in-parkinson-s-disease
#5
Per Selnes, Ane Løvli Stav, Krisztina K Johansen, Atle Bjørnerud, Christopher Coello, Eirik Auning, Lisa Kalheim, Ina Selseth Almdahl, Erik Hessen, Henrik Zetterberg, Kaj Blennow, Dag Aarsland, Tormod Fladby
OBJECTIVE: Cognitive impairment is frequent in Parkinson's disease, but the underlying mechanisms are insufficiently understood. Because cortical metabolism is reduced in Parkinson's disease and closely associated with cognitive impairment, and CSF amyloid-β species are reduced and correlate with neuropsychological performance in Parkinson's disease, and amyloid-β release to interstitial fluid may be related to synaptic activity; we hypothesize that synapse dysfunction links cortical hypometabolism, reduced CSF amyloid-β, and presynaptic deposits of α-synuclein...
October 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29046650/alcohol-binge-drinking-and-executive-functioning-during-adolescent-brain-development
#6
Soledad Gil-Hernandez, Patricia Mateos, Claudia Porras, Raquel Garcia-Gomez, Enrique Navarro, Luis M Garcia-Moreno
Alcohol consumption in adolescents causes negative effects on familiar, social, academic life, as well as neurocognitive alterations. The binge drinking (BD) pattern of alcohol is characterized by the alternation of episodes of heavy drinking in a short interval of time, and periods of abstinence, a practice that can result in important brain alterations; even more than regular alcohol consumption. The prefrontal cortex, which acts as neural support for the executive processes, is particularly affected by alcohol; however, not all studies are in agreement about how BD alcohol consumption affects executive functioning...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29046648/the-relationships-among-tryptophan-kynurenine-indoleamine-2-3-dioxygenase-depression-and-neuropsychological-performance
#7
Knut A Hestad, Knut Engedal, Jon E Whist, Per G Farup
It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan (TRP) metabolic pathway, resulting in reduced Serotonin. In this study, we examined KYN, TRP, and the ratio of KYN to TRP concentrations × 10(3) (KT Ratio) in serum and cerebrospinal fluid (CSF) in (a) a group of depressed patients and (b) a control group of patients referred to a neurologic outpatient clinic for whom no specific diagnosis could be established...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29046635/mirna-in-circulating-microvesicles-as-biomarkers-for-age-related-cognitive-decline
#8
Asha Rani, Andrew O'Shea, Lara Ianov, Ronald A Cohen, Adam J Woods, Thomas C Foster
Community dwelling older individuals from the North Florida region were examined for health status and a comprehensive neuropsychological battery, including the Montreal Cognitive Assessment (MoCA), was performed on each participant. A subpopulation (58 females and 39 males) met the criteria for age (60-89) and no evidence of mild cognitive impairment, with a MoCA score ≥23. Despite the stringent criteria for participation, MoCA scores were negatively correlated within the limited age range. Extracellular microvesicles were isolated from the plasma and samples were found to be positive for the exosome marker CD63, with an enrichment of particles within the size range for exosomes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29046290/re-establishing-brain-networks-in-patients-with-esrd-after-successful-kidney-transplantation
#9
Hui Juan Chen, Jiqiu Wen, Rongfeng Qi, Jianhui Zhong, U Joseph Schoepf, Akos Varga-Szemes, Virginia W Lesslie, Xiang Kong, Yun Fei Wang, Qiang Xu, Zhe Zhang, Xue Li, Guang Ming Lu, Long Jiang Zhang
BACKGROUND AND OBJECTIVES: Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging...
October 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29042889/screening-ability-of-subjective-memory-complaints-informant-reports-for-cognitive-decline-and-their-combination-in-memory-clinic-setting
#10
Seon Jin Yim, Dahyun Yi, Min Soo Byun, Young Min Choe, Hyo Jung Choi, Hyewon Baek, Bo Kyung Sohn, Jee Wook Kim, Eui-Jung Kim, Dong Young Lee
OBJECTIVE: This study aimed to compare the accuracy of subjective memory complaints, informant-reports for cognitive declines, and their combination for screening cognitive disorders in memory clinic setting. METHODS: One-hundred thirtytwo cognitively normal (CN), 136 mild cognitive impairment (MCI), and 546 dementia who visited the memory clinic in the Seoul National University Hospital underwent standardized clinical evaluation and comprehensive neuropsychological assessment...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29042856/the-utility-of-a-computerized-algorithm-based-on-a-multi-domain-profile-of-measures-for-the-diagnosis-of-attention-deficit-hyperactivity-disorder
#11
Alessandro Crippa, Christian Salvatore, Erika Molteni, Maddalena Mauri, Antonio Salandi, Sara Trabattoni, Carlo Agostoni, Massimo Molteni, Maria Nobile, Isabella Castiglioni
The current gold standard for diagnosis of attention deficit/hyperactivity disorder (ADHD) includes subjective measures, such as clinical interview, observation, and rating scales. The significant heterogeneity of ADHD symptoms represents a challenge for this assessment and could prevent an accurate diagnosis. The aim of this work was to investigate the ability of a multi-domain profile of measures, including blood fatty acid (FA) profiles, neuropsychological measures, and functional measures from near-infrared spectroscopy (fNIRS), to correctly recognize school-aged children with ADHD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29042492/validation-of-the-telephone-interview-of-cognitive-status-and-telephone-montreal-cognitive-assessment-against-detailed-cognitive-testing-and-clinical-diagnosis-of-mild-cognitive-impairment-after-stroke
#12
Vera Zietemann, Anna Kopczak, Claudia Müller, Frank Arne Wollenweber, Martin Dichgans
BACKGROUND AND PURPOSE: Assessment of cognitive status poststroke is recommended by guidelines but follow-up can often not be done in person. The Telephone Interview of Cognitive Status (TICS) and the Telephone Montreal Cognitive Assessment (T-MoCA) are considered useful screening instruments. Yet, evidence to define optimal cut-offs for mild cognitive impairment (MCI) after stroke is limited. METHODS: We studied 105 patients enrolled in the prospective DEDEMAS study (Determinants of Dementia After Stroke; NCT01334749)...
October 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29041995/reproducibility-of-cognitive-profiles-in-psychosis-using-cluster-analysis
#13
Kathryn E Lewandowski, Justin T Baker, Julie M McCarthy, Lesley A Norris, Dost Öngür
OBJECTIVES: Cognitive dysfunction is a core symptom dimension that cuts across the psychoses. Recent findings support classification of patients along the cognitive dimension using cluster analysis; however, data-derived groupings may be highly determined by sampling characteristics and the measures used to derive the clusters, and so their interpretability must be established. We examined cognitive clusters in a cross-diagnostic sample of patients with psychosis and associations with clinical and functional outcomes...
October 18, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29041993/development-of-a-contextualized-version-of-the-multiple-errands-test-for-people-with-substance-dependence
#14
Carlos Valls-Serrano, Antonio Verdejo-García, Xavier Noël, Alfonso Caracuel
BACKGROUND: Substance dependence is associated with deficits in several areas of executive functioning, such as planning and multitasking. Traditional tests of executive functioning have been criticized for their low ecological validity. Shallice and Burgess (1991) developed the Multiple Errands Test (MET), where participants are required to perform multiple tasks in a real-world setting. In this study, we aimed to adapt the MET for use in populations with substance dependence. OBJECTIVES: This study aimed to: (1) examine the applicability of a contextualized version of the Multiple Errands Test, namely, the Multiple Errands Test - Contextualized Version (MET-CV); (2) study the testing context reliability and convergent validity of MET-CV scores; (3) compare the performance of people with substance dependence to a control group...
October 18, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29041878/-influence-of-sympathetic-denervation-of-the-renal-artery-on-the-level-of-arterial-blood-pressure-cerebral-blood-flow-and-cognitive-function-in-patients-with-resistant-arterial-hypertension
#15
Y N Efimova, A V Lichikaki, B Y Lishmanov
PURPOSE: To study the effect of radiofrequency ablation of renal arteries on regional cerebral blood flow and cognitive function in patients with resistant arterial hypertension (AH). MATERIAL AND METHODS: Transcatheter renal denervation (TRD) was performed in 17 patients with resistant AH. Examination before and after TRD included SPECT with mTc-HMPAO, 24-hours blood pressure (BP) monitoring, and comprehensive neuropsychological testing. Fifteen patients without angiographic signs of carotid atherosclerosis, coronary artery disease and AH, neurological and psychiatric disorders were investigated as control group...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041835/assessment-of-executive-function-in-adhd-adolescents-contribution-of-performance-tests-and-rating-scales
#16
Virginia Krieger, Juan Antonio Amador-Campos
This study aimed to analyze performance on measures of neuropsychological and behavioral executive functions (EF) in adolescents with attention deficit hyperactivity disorder (ADHD), and to evaluate the utility of performance-based tests for predicting scores on behavioral EF ratings. One hundred eighteen adolescents (75 ADHD and 43 controls) aged 12-16 years performed neuropsychological tests and completed a behavior rating scale of EF. The ADHD group presented significantly lower scores than controls on Full Scale IQ (FSIQ) and all indexes of the WISC-IV, except the verbal comprehension index (VCI)...
October 18, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29040946/neuropsychological-predictors-of-response-to-cognitive-behavioral-therapy-for-posttraumatic-stress-disorder-in-persons-with-severe-mental-illness
#17
Kim T Mueser, Susan R McGurk, Haiyi Xie, Elisa E Bolton, M Kay Jankowski, Weili Lu, Stanley D Rosenberg, Rosemarie Wolfe
This study examined whether cognitive functioning was related to treatment outcomes in persons with severe mental illness who received a cognitive behavioral therapy (CBT) program for co-occurring posttraumatic stress disorder (PTSD). The study sample was drawn from a larger controlled trial of 108 persons with severe mental illness and PTSD comparing the effects of CBT with treatment as usual on PTSD and related outcomes, with assessments conducted at baseline, post-treatment, and 3- and 6-month follow-ups...
October 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29040828/neuropsychological-functioning-and-brain-energetics-of-drug-resistant-mesial-temporal-lobe-epilepsy-patients
#18
Camila Moreira Osório, Alexandra Latini, Rodrigo Bainy Leal, Maria Emília Rodrigues de Oliveira Thais, Helena Dresch Vascouto, Aline Pertile Remor, Mark William Lopes, Marcelo Neves Linhares, Juliana Ben, Roberta de Paula Martins, Rui Daniel Prediger, Alexandre Ademar Hoeller, Hans Joachim Markowitsch, Peter Wolf, Kátia Lin, Roger Walz
Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n=21), surgically treated patients with MTLE-HS (n=32, left side=17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency...
October 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29039851/quantifying-person-level-brain-network-functioning-to-facilitate-clinical-translation
#19
T M Ball, A N Goldstein-Piekarski, J M Gatt, L M Williams
Although advances in neuroimaging have yielded insights into the intrinsic organization of human brain networks and their relevance to psychiatric and neurological disorders, there has been no translation of these insights into clinical practice. One necessary step toward clinical translation is identifying a summary metric of network function that is reproducible, reliable, and has known normative data, analogous to normed neuropsychological tests. Our aim was therefore to establish the proof of principle for such a metric, focusing on the default mode network (DMN)...
October 17, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29039829/-factors-for-the-development-of-persistent-postoperative-cognitive-dysfunction-in-patients-undergoing-coronary-artery-bypass-surgery-under-extracorporeal-circulation
#20
O A Trubnikova, I V Tarasova, O V Maleva, E S Kagan, O L Barbarash, L S Barbarash
AIM: To analyze the factors contributing to the increased risk of persistent postoperative cognitive dysfunction (POCD) in patients undergoing coronary artery bypass surgery (CABS) under extracorporeal circulation (EC). SUBJECTS AND METHODS: 257 male patients aged 45 to 69 years with coronary heart disease (CHD) undergoing elective CABS under EC were examined. In addition to conventional clinical examination, all the patients underwent neuropsychological testing 3-5 days before, 7-14 days and 1 year after CABS...
2017: Terapevticheskiĭ Arkhiv
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