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https://www.readbyqxmd.com/read/28731870/the-association-of-cognitive-reserve-in-chronic-phase-functional-and-neuropsychological-outcomes-following-traumatic-brain-injury
#1
Jacob B Leary, Grace Y Kim, Catherine L Bradley, Uzma Z Hussain, Maryanne Sacco, Martha Bernad, John Collins, John Dsurney, Leighton Chan
OBJECTIVE: Examine the association of cognitive reserve (CR) factors (estimated premorbid intelligence quotient [IQ], years of education, and occupational attainment) and traumatic brain injury (TBI) severity with functional and neuropsychological outcomes 1 to 5 years following TBI. PARTICIPANTS: Patients with mild (N = 58), moderate (N = 25), or severe (N = 17) TBI. MAIN MEASURES: Cognitive reserve factors (estimated premorbid IQ, years of education, and occupational attainment); neuropsychological test battery; Glasgow Outcome Scale-Extended; Short Form-36 Health Survey...
July 20, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28731453/topological-alterations-and-symptom-relevant-modules-in-the-whole-brain-structural-network-in-semantic-dementia
#2
Junhua Ding, Keliang Chen, Weibin Zhang, Ming Li, Yan Chen, Qing Yang, Yingru Lv, Qihao Guo, Zaizhu Han
BACKGROUND: Semantic dementia (SD) is characterized by a selective decline in semantic processing. Although the neuropsychological pattern of this disease has been identified, its topological global alterations and symptom-relevant modules in the whole-brain anatomical network have not been fully elucidated. OBJECTIVE: This study aims to explore the topological alteration of anatomical network in SD and reveal the modules associated with semantic deficits in this disease...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731452/temporal-order-of-alzheimer-s-disease-related-cognitive-marker-changes-in-blsa-and-wrap-longitudinal-studies
#3
Murat Bilgel, Rebecca L Koscik, Yang An, Jerry L Prince, Susan M Resnick, Sterling C Johnson, Bruno M Jedynak
Investigation of the temporal trajectories of currently used neuropsychological tests is critical to identifying earliest changing measures on the path to dementia due to Alzheimer's disease (AD). We used the Progression Score (PS) method to characterize the temporal trajectories of measures of verbal memory, executive function, attention, processing speed, language, and mental status using data spanning normal cognition, mild cognitive impairment, and AD from 1,661 participants with a total of 7,839 visits (age at last visit 77...
July 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731439/antihypertensive-treatment-is-associated-with-mri-derived-markers-of-neurodegeneration-and-impaired-cognition-a-propensity-weighted-cohort-study
#4
Jodi D Edwards, Joel Ramirez, Brandy L Callahan, Sheldon W Tobe, Paul Oh, Courtney Berezuk, Krista Lanctôt, Walter Swardfager, Sean Nestor, Alexander Kiss, Stephen Strother, Sandra E Black
BACKGROUND: Hypertension is an important risk factor for Alzheimer's disease (AD) and cerebral small vessel disease. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are common anti-hypertensive treatments, but have differential effects on cortical amyloid. OBJECTIVE: The objective of this study was to evaluate associations between anti-hypertensive treatment, brain volume, and cognition, using a propensity-weighted analysis to account for confounding by indication...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731436/impaired-processing-of-serial-order-determines-working-memory-impairments-in-alzheimer-s-disease
#5
Maya De Belder, Patrick Santens, Anne Sieben, Wim Fias
BACKGROUND: Working memory (WM) problems are commonly observed in Alzheimer's disease (AD), but the affected mechanisms leading to impaired WM are still insufficiently understood. The ability to efficiently process serial order in WM has been demonstrated to be fundamental to fluent daily life functioning. The decreased capability to mentally process serial position in WM has been put forward as the underlying explanation for generally compromised WM performance. OBJECTIVE: Determine which mechanisms, such as order processing, are responsible for deficient WM functioning in AD...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731429/severity-of-depression-impacts-imminent-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease
#6
Michaela Defrancesco, Josef Marksteiner, Georg Kemmler, Walter Wolfgang Fleischhacker, Imrich Blasko, Eberhard A Deisenhammer
BACKGROUND: Mild cognitive impairment (MCI) has been suggested to represent a prodromal stage of dementia and to confer a high risk for conversion to dementia Alzheimer's type (DAT). OBJECTIVES: In this study, we examined the predictive value of depressive symptoms and neuropsychological variables on conversion of MCI to DAT. METHODS: Neuropsychological and clinical follow-up data of 260 MCI patients seen at the Psychiatric Memory Clinic of the Medical University of Innsbruck between 2005 and 2015 were analyzed retrospectively...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731266/a-randomized-double-blind-placebo-controlled-crossover-study-of-the-effects-of-levetiracetam-on-cognition-mood-and-balance-in-healthy-older-adults
#7
Mike R Schoenberg, Ruba S Rum, Katie E Osborn, Mary Ann Werz
OBJECTIVE: The cognitive and mood effects of levetiracetam (LEV) in older adults are not known. This study compared the cognitive and mood effects of LEV to placebo in healthy older adults. METHODS: Cognitive, mood, and balance variables were compared between LEV and placebo using a randomized, double-blind, placebo-controlled crossover study with two 5-week treatment periods. Healthy volunteers (n = 20) aged 65-80 (mean age 72.4) received either LEV or placebo in which the LEV target dose was 1,000 mg/day...
July 21, 2017: Epilepsia
https://www.readbyqxmd.com/read/28730563/functional-connectivity-and-cognitive-impairment-in-migraine-with-and-without-aura
#8
Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
BACKGROUND: Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack. METHODS: Twenty-eight migraine patients (14 without and 14 with aura) and 14 matched normal controls, were consecutively recruited...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28729755/social-cognition-deficits-current-position-and-future-directions-for-neuropsychological-interventions-in-cerebrovascular-disease
#9
REVIEW
Progress Njomboro
Neuropsychological assessments of cognitive dysfunction in cerebrovascular illness commonly target basic cognitive functions involving aspects of memory, attention, language, praxis, and number processing. Here, I highlight the clinical importance of often-neglected social cognition functions. These functions recruit a widely distributed neural network, making them vulnerable in most cerebrovascular diseases. Sociocognitive deficits underlie most of the problematic social conduct observed in patients and are associated with more negative clinical outcomes (compared to nonsocial cognitive deficits)...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28728964/association-between-proton-pump-inhibitor-use-and-cognitive-function-in-women
#10
Paul Lochhead, Kaitlin Hagan, Amit D Joshi, Hamed Khalili, Long H Nguyen, Francine Grodstein, Andrew T Chan
BACKGROUND & AIMS: Studies have reported associations between proton pump inhibitor (PPI) use and dementia. However, data are lacking on long-term PPI use and cognitive function. We therefore examined associations between PPI use and performance in tests of cognitive function. Because of shared clinical indications, we examined associations for H2 receptor antagonists (H2RAs) as a secondary aim. METHODS: We used prospectively collected data on medication use and other potential risk factors from 13,864 participants in the Nurses' Health Study II who had completed a self-administered computerized neuropsychological test battery...
July 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28728465/evaluating-the-test-retest-reliability-of-symptom-indices-associated-with-the-impact-post-concussion-symptom-scale-pcss
#11
Victoria C Merritt, Megan L Bradson, Jessica E Meyer, Peter A Arnett
OBJECTIVE: The Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is a commonly used tool in sports concussion assessment. While test-retest reliabilities have been established for the ImPACT cognitive composites, few studies have evaluated the psychometric properties of the ImPACT's Post-Concussion Symptom Scale (PCSS). The purpose of this study was to establish the test-retest reliability of symptom indices associated with the PCSS. PARTICIPANTS AND METHODS: Participants included 38 undergraduate students (50...
July 20, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28727639/effects-of-12-week-resistance-exercise-on-electroencephalogram-patterns-and-cognitive-function-in-the-elderly-with-mild-cognitive-impairment-a-randomized-controlled-trial
#12
Soon-Gook Hong, June-Hong Kim, Tae-Won Jun
OBJECTIVE: To investigate the effects of a 12-week resistance exercise program with an elastic band on electroencephalogram (EEG) patterns and cognitive function in elderly patients with mild cognitive impairment (MCI). DESIGN: Randomized controlled trial. SETTING: Community center. PARTICIPANTS: Twenty-two subjects with MCI and 25 healthy volunteer subjects were randomly assigned to 1 of 4 groups: subjects with MCI who undertook the exercise program (MCI-EX; n = 10), an MCI control group (MCI-Con; n = 12), a healthy volunteer exercise group (NG-EX; n = 12), and a healthy volunteer control group (NG-Con; n = 13)...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28726593/validation-and-normalization-of-the-tower-of-london-drexel-university-test-2nd-edition-in-an-adult-population-with-intellectual-disability
#13
Javier García-Alba, Susanna Esteba-Castillo, Miguel Ángel Castellanos López, Emili Rodríguez Hidalgo, Nuria Ribas Vidal, Fernando Moldenhauer Díaz, Ramón Novell-Alsina
Despite how important it is to assess executive functioning in persons with Intellectual Disability (ID), instruments adapted and validated for this population are scarce. This study's primary goal was to find evidence for the validity of the ID version of the Tower of London (TOLDXtm) test in persons with mild (IDMi) and moderate (IDMo) levels of ID with Down Syndrome (DS). A multicenter study was carried out. Subjects (n = 63, ≥ 39 years old) had DS with mild (n = 39) or moderate ID (n = 24) with no minor neurocognitive disorder or Alzheimer's disease...
July 20, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28726502/spatial-reorientation-decline-in-aging-the-combination-of-geometry-and-landmarks
#14
Alessandro O Caffò, Antonella Lopez, Giuseppina Spano, Silvia Serino, Pietro Cipresso, Fabrizio Stasolla, Michelina Savino, Giulio E Lancioni, Giuseppe Riva, Andrea Bosco
OBJECTIVES: The study is focused on the assessment of reorientation skills in a sample of community-dwelling elderly people, manipulating landmarks and geometric (layout) information. METHOD: A neuropsychological assessment was administered to 286 elderly participants, divided into six groups (healthy controls, HC; four subgroups of participants with mild cognitive impairment, MCI; participants with probable dementia, Prob_D) and tested with the Virtual Reorientation Test (VReoT)...
July 20, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28726233/-cannabidiol-its-use-in-refractory-epilepsies
#15
G Pesantez-Rios, L Armijos-Acurio, R Jimbo-Sotomayor, S I Pascual-Pascual, G Pesantez-Cuesta
INTRODUCTION: Some epileptic syndromes are characterised by seizures that are difficult to control and are associated to delayed neuropsychomotor development, which results in a deterioration in the patient's quality of life as well as in that of his or her family. AIM: To evaluate the use of cannabidiol as adjuvant therapy in patients with refractory epilepsies. PATIENTS AND METHODS: An observational study was conducted by means of a survey addressed to the patient's caregiver...
August 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28726177/the-reliability-paradox-why-robust-cognitive-tasks-do-not-produce-reliable-individual-differences
#16
Craig Hedge, Georgina Powell, Petroc Sumner
Individual differences in cognitive paradigms are increasingly employed to relate cognition to brain structure, chemistry, and function. However, such efforts are often unfruitful, even with the most well established tasks. Here we offer an explanation for failures in the application of robust cognitive paradigms to the study of individual differences. Experimental effects become well established - and thus those tasks become popular - when between-subject variability is low. However, low between-subject variability causes low reliability for individual differences, destroying replicable correlations with other factors and potentially undermining published conclusions drawn from correlational relationships...
July 19, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28726168/cognitive-interventions-for-cognitively-healthy-mildly-impaired-and-mixed-samples-of-older-adults-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Catherine M Mewborn, Cutter A Lindbergh, L Stephen Miller
Cognitive interventions may improve cognition, delay age-related cognitive declines, and improve quality of life for older adults. The current meta-analysis was conducted to update and expand previous work on the efficacy of cognitive interventions for older adults and to examine the impact of key demographic and methodological variables. EBSCOhost and Embase online databases and reference lists were searched to identify relevant randomized-controlled trials (RCTs) of cognitive interventions for cognitively healthy or mildly impaired (MCI) older adults (60+ years)...
July 19, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28725201/nature-and-specificity-of-gestural-disorder-in-children-with-developmental-coordination-disorder-a-multiple-case-study
#18
Orianne Costini, Arnaud Roy, Chrystelle Remigereau, Sylvane Faure, Catherine Fossoud, Didier Le Gall
Aim: Praxis assessment in children with developmental coordination disorder (DCD) is usually based on tests of adult apraxia, by comparing across types of gestures and input modalities. However, the cognitive models of adult praxis processing are rarely used in a comprehensive and critical interpretation. These models generally involve two systems: a conceptual system and a production system. Heterogeneity of deficits is consistently reported in DCD, involving other cognitive skills such as executive or visual-perceptual and visuospatial functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28724645/effect-of-maternal-high-dosages-of-folic-acid-supplements-on-neurocognitive-development-in-children-at-4-5-years-of-age-the-prospective-birth-cohort-infancia-y-medio-ambiente-inma-study
#19
Desirée Valera-Gran, Eva M Navarrete-Muñoz, Manuela Garcia de la Hera, Ana Fernández-Somoano, Adonina Tardón, Jesús Ibarluzea, Nekane Balluerka, Mario Murcia, Llúcia González-Safont, Dora Romaguera, Jordi Julvez, Jesús Vioque
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 μg/d) on child neurocognitive outcomes.Objective: The objective of the study was to examine the association between the use of high dosages of FASs during pregnancy and child neuropsychological development at ages 4-5 y...
July 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28724366/predicting-progression-of-mild-cognitive-impairment-to-dementia-using-neuropsychological-data-a-supervised-learning-approach-using-time-windows
#20
Telma Pereira, Luís Lemos, Sandra Cardoso, Dina Silva, Ana Rodrigues, Isabel Santana, Alexandre de Mendonça, Manuela Guerreiro, Sara C Madeira
BACKGROUND: Predicting progression from a stage of Mild Cognitive Impairment to dementia is a major pursuit in current research. It is broadly accepted that cognition declines with a continuum between MCI and dementia. As such, cohorts of MCI patients are usually heterogeneous, containing patients at different stages of the neurodegenerative process. This hampers the prognostic task. Nevertheless, when learning prognostic models, most studies use the entire cohort of MCI patients regardless of their disease stages...
July 19, 2017: BMC Medical Informatics and Decision Making
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