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obstructive apnea

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https://www.readbyqxmd.com/read/28823109/comparison-of-two-home-sleep-testing-devices-with-different-strategies-for-diagnosis-of-osa
#1
Tyler Gumb, Akosua Twumasi, Shahnaz Alimokhtari, Alan Perez, Kathleen Black, David M Rapoport, Jag Sunderram, Indu Ayappa
PURPOSE: Home sleep testing devices are being widely used in diagnosis/screening for obstructive sleep apnea (OSA). We examined differences in OSA metrics obtained from two devices with divergent home monitoring strategies, the Apnea Risk Evaluation System (ARES™, multiple signals plus forehead reflectance oximetry) and the Nonin WristOx2™ (single channel finger transmission pulse oximeter), compared to differences from night-night variability of OSA. METHODS: One hundred fifty-two male/26 female subjects (BMI = 30...
August 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28823074/single-anastomosis-duodeno-ileal-switch-sadis-a-systematic-review-of-efficacy-and-safety
#2
Saeed Shoar, Lauren Poliakin, Rebecca Rubenstein, Alan A Saber
BACKGROUND: Owing to the possibility of weight regain after the long-term follow-up of gastric bypass patients and because of the high morbidity of biliopancreatic diversion with duodenal switch, single-anastomosis duodeno-ileal switch (SADIS) has emerged as a rescue procedure in bariatric surgery. OBJECTIVE: The purpose of this review is to summarize the literature data on SADIS. SETTING: University Hospital, NY. METHODS: A comprehensive literature review was performed through October 2016 to identify English studies on SADIS performed in human subjects...
August 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28822964/moderate-to-severe-obstructive-sleep-apnea-is-associated-with-telomere-lengthening
#3
Katarzyna Polonis, Virend K Somers, Christiane Becari, Naima Covassin, Phillip J Schulte, Brooke R Druliner, Ruth A Johnson, Krzysztof Narkiewicz, Lisa A Boardman, Prachi Singh
Obstructive sleep apnea (OSA) is associated with cardiometabolic diseases. Telomere shortening is linked to hypertension, diabetes mellitus, and cardiovascular diseases. Because these conditions are highly prevalent in OSA, we hypothesized that telomere length (TL) would be reduced in OSA patients. We identified 106 OSA and 104 non-OSA subjects who underwent polysomnography evaluation. Quantitative PCR was used to measure telomere length in genomic DNA isolated from peripheral blood samples. The association between OSA and TL was determined using unadjusted and adjusted linear models...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822761/down-regulation-of-vascular-ppar-%C3%AE-contributes-to-endothelial-dysfunction-in-high-fat-diet-induced-obese-mice-exposed-to-chronic-intermittent-hypoxia
#4
Yanan Zhang, Chunlian Zhang, Haiou Li, Jingdong Hou
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is associated with endothelial dysfunction. The prevalence of OSA is linked to an epidemic of obesity. CIH has recently been reported to cause endothelial dysfunction in diet-induced obese animals by exaggerating oxidative stress and inflammation, but the underlying mechanism remains unclear. PPAR-γ, a ligand-inducible transcription factor that exerts anti-oxidant and anti-inflammatory effects, is down-regulated in the peripheral tissues in diet-induce obesity...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28822675/precise-osteotomies-for-mandibular-distraction-in-infants-with-robin-sequence-using-virtual-surgical-planning
#5
C M Resnick
Mandibular distraction osteogenesis (MDO) has become the first-line operation in many centers for the management of obstructive sleep apnea (OSA) in infants with (Pierre) Robin sequence (RS) not relieved by non-surgical approaches. Preoperative virtual surgical planning (VSP) may improve precision and decrease complications for this operation. This article reports a retrospective study of RS infants who underwent MDO for OSA using preoperative VSP and three-dimensionally printed cutting guides performed by one surgeon...
August 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28822508/prevalence-and-characteristics-of-resistant-hypertensive-patients-in-an-asian-population
#6
Rabia Naseem, Arsalan Majeed Adam, Fiza Khan, Adiya Dossal, Ibrahim Khan, Ammara Khan, Hannah Paul, Hafsa Jawed, Aisha Aslam, Faez Muhammad Syed, Muhammad Ahsen Niazi, Shehzeen Nadeem, Aruba Khan, Amber Zia, Mohammad Hussham Arshad
BACKGROUND: Resistant hypertension is a well-recognized clinical challenge yet there are no reported data on its prevalence in Pakistan. These patients are subjected to a higher risk of developing hypertensive complications. The objective of our study was to evaluate the prevalence and determinants of resistant hypertension in an Asian cohort of hypertensive patients. METHODS: This cross-sectional study was carried out among hypertensive patients visiting a tertiary care hospital in Karachi from September-December 2015...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822412/-feasibility-of-single-staged-han-uvulopalatopharyngoplasty-with-septoplasty-in-adults-with-obstructive-sleep-apnea-hypopnea-syndrome
#7
S G Xiu, D D Yu, Y M Wang, S D Gao
Objective: To explore the feasibility and therapeutic effect of single-staged Han-uvulopalatopharyngoplasty with septoplasty in adults with obstructive sleep apnea-hypopnea syndrome. Methods: Ninety six cases with OSAHS were diagnosed by polysomnography, and they all had retropalatal obstruction and deviation of nasal septum. Patients were divided into study group(48 cases) and control group(48 cases) randomly. Cases in study group were simultaneously treated with Han-uvulopalatopharyngoplasty and septoplasty, while cases in control group were only treated with Han-uvulopalatopharyngoplasty...
August 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28822411/-effect-of-treating-obstructive-sleep-apnea-hypopnea-syndrome-on-chronic-cough-in-children
#8
C Pang, J Q Liang, Q L Gu
Objective: To understand the effect of treating obstructive sleep apnea hypopnea syndrome (OSAHS) on chronic cough in children. Methods: A total of 100 consecutive children with OSAHS diagnosed by polysomnography(PSG) and chronic cough were included in this study. All children underwent cough condition assessment, OSA-18 scales and MS-IOS before and after surgery, and all children were followed-up for 3 months. Children were separated into three groups according to the severity of OSAHS. Related parameters like Zr, Rf, R5, R20, X5, X35, Rc, Rp obtained from MS-IOS, OSA-18 scores and cough scores were compared between different groups using paired t-test or Wilcoxon sum test...
August 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28822033/clinical-and-polysomnographic-characteristics-of-excessive-daytime-sleepiness-in-children
#9
Jiwon Lee, Geonyoub Na, Eun Yeon Joo, Munhyang Lee, Jeehun Lee
PURPOSE: This study aimed to delineate the clinical and polysomnography (PSG) characteristics of sleep disorders in children with excessive daytime sleepiness (EDS). METHODS: Between February 2002 and June 2015, 622 pediatric patients with EDS were evaluated with overnight PSG and the Multiple Sleep Latency Test at the Samsung Medical Center. The medical records; questionnaire responses about depression, sleepiness, sleep habits; and sleep study data of 133 patients without obstructive sleep apnea (OSA) were reviewed retrospectively...
August 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28822020/polysomnographic-determinants-of-requirement-for-advanced-positive-pressure-therapeutic-options-for-obstructive-sleep-apnea
#10
Anupama Gupta, Garima Shukla
BACKGROUND: A small percentage of adult patients with severe obstructive sleep apnea (OSA) has been recognized to be extraordinarily difficult to treat with conventional continuous or Bi-level positive airway pressure (together referred to as PAP) therapy. AIM AND OBJECTIVES: The aim of this study was to determine polysomnographic (PSG) characteristics, which may help predict the requirement for advanced therapeutic options for OSA. METHODS: Consecutive patients who underwent PAP titration at our sleep laboratory over a 2-year period were included...
August 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28821856/smoking-obstructive-sleep-apnea-syndrome-and-their-combined-effects-on-metabolic-parameters-evidence-from-a-large-cross-sectional-study
#11
Huaming Zhu, Huajun Xu, Rui Chen, Suru Liu, Yunyan Xia, Yiqun Fu, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan
Metabolic disorders have been separately associated with obstructive sleep apnea syndrome (OSAS) and smoking. However, no study has examined their interactions with metabolic parameters, including insulin resistance and dyslipidemia. To investigate whether the combination of OSAS and smoking results in an additive detriment in metabolic disorder parameters, we enrolled consecutive adult men during 2014-2015. Fasted blood samples were taken to determine glucose, insulin, and lipid levels. A questionnaire including an item on smoking pack-year exposure was administered, and the Epworth Sleepiness Scale and overnight polysomnography were performed...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821224/patients-with-symptoms-and-characteristics-consistent-with-obstructive-sleep-apnea-are-at-a-higher-risk-for-acute-and-subacute-stent-thrombosis-after-percutaneous-coronary-stent-implantation-a-single-center-case-control-study
#12
Yanhua Li, Shanshan Yang, Si Chen, Xinhong Guo, Yundai Chen
BACKGROUND: To determine if obstructive sleep apnea (OSA) is a risk factor for early stent thrombosis (EST; within 30 days) after percutaneous coronary intervention (PCI). METHODS: This case-control study involved 23 patients with angiographically confirmed EST after PCI (case group) and 92 PCI patients (control group) who did not develop stent thrombosis during a 2-year follow-up. Patients with symptoms and characteristics consistent with OSA (hereinafter referred to as OSA) were identified using the Berlin questionnaire, and the general characteristics of the patients and their treatments as well as outcomes were recorded...
August 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28820843/cephalometric-predictors-of-clinical-severity-in-treacher-collins-syndrome
#13
Elcin Esenlik, Natalie M Plana, Barry H Grayson, Roberto L Flores
BACKGROUND: The aim of this study is to identify cephalometric measurements associated with clinical severity in patients with Treacher Collins Syndrome (TCS). METHODS: A retrospective single-institutional review of patients with TCS was conducted. Pre-operative cephalograms and computed tomography scans (n=30) were evaluated. 50 cephalometric measurements were compared to age-specific normative data using ANOVA. These cephalometric measurements and the patient's Pruzansky classification were correlated to clinical severity using Spearman analysis...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28820743/sleep-apnea-a-review-of-diagnostic-sensors-algorithms-and-therapies
#14
Mehdi Shokoueinejad, Chris Fernandez, Emily Carroll, Fa Wang, Jake Levin, Sam Rusk, Nick Glattard, Ashley Mulchrone, Xuan Zhang, Ailiang Xie, Mihaela Teodorescu, Jerome Dempsey, John Webster
While public awareness of sleep related disorders is growing, sleep apnea syndrome (SAS) remains a public health and economic challenge. Over the last two decades, extensive controlled epidemiologic research has clarified the incidence, risk factors including the obesity epidemic, and global prevalence of obstructive sleep apnea (OSA), as well as establishing a growing body of literature linking OSA with cardiovascular morbidity, mortality, metabolic dysregulation, and neurocognitive impairment. The US Institute of Medicine Committee on Sleep Medicine estimates that 50-70 million US adults have sleep or wakefulness disorders...
August 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28819002/feedback-modulation-of-surrounding-pressure-determines-the-onset-of-negative-effort-dependence-in-a-collapsible-tube-bench-model-of-the-pharyngeal-airway
#15
Christopher Lambeth, Benjamin Kolevski, Terence Charles Amis, Kristina Kairaitis
Negative effort dependence (NED), decreased airflow despite increased driving pressure, has been proposed as a specific obstructive sleep apnea (OSA) phenotypic characteristic. We examined conditions under which NED occurs in a collapsible tube, chamber enclosed, pharyngeal airway bench model, focusing on relationships with surrounding pressure levels and longitudinal strain. Using a vacuum source, graded airflows (V ̇, 0-5 L/s) were generated through a thin walled latex tube enclosed within a rigid, cylindrical chamber, sealed with initial chamber pressures (Pci) of 0-5 cmH2O (separate runs), or open to atmosphere...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28818483/intermittent-hypoxia-and-cancer-undesirable-bed-partners
#16
REVIEW
Isaac Almendros, David Gozal
The deleterious effects of intermittent hypoxia (IH) on cancer biology have been primarily evaluated in the context of the aberrant circulation observed in solid tumors which results in recurrent intra-tumoral episodic hypoxia. From those studies, IH has been linked to an accelerated tumor progression, metastasis and resistance to therapies. More recently, the role of IH in cancer has also been studied in the context of obstructive sleep apnea (OSA), since IH is a hallmark characteristic of this condition. Such recent studies are undoubtedly adding more information regarding the role of IH on tumor malignancy...
August 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28818154/physiology-based-modeling-may-predict-surgical-treatment-outcome-for-obstructive-sleep-apnea
#17
Yanru Li, Jingying Ye, Demin Han, Xin Cao, Xiu Ding, Yuhuan Zhang, Wen Xu, Jeremy Orr, Rachel Jen, Scott Sands, Atul Malhotra, Robert Owens
STUDY OBJECTIVES: To test whether the integration of both anatomical and nonanatomical parameters (ventilatory control, arousal threshold, muscle responsiveness) in a physiology-based model will improve the ability to predict outcomes after upper airway surgery for obstructive sleep apnea (OSA). METHODS: In 31 patients who underwent upper airway surgery for OSA, loop gain and arousal threshold were calculated from preoperative polysomnography (PSG). Three models were compared: (1) a multiple regression based on an extensive list of PSG parameters alone; (2) a multivariate regression using PSG parameters plus PSG-derived estimates of loop gain, arousal threshold, and other trait surrogates; (3) a physiological model incorporating selected variables as surrogates of anatomical and nonanatomical traits important for OSA pathogenesis...
August 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28817760/association-between-hypercoagulability-and-severe-obstructive-sleep-apnea
#18
Seung-No Hong, Hee-Chul Yun, Joon Hyuk Yoo, Seung Hoon Lee
Importance: Obstructive sleep apnea (OSA) is related to the increased risk of cardiovascular disease. Although the pathogenesis of this association remains unclear, an alteration in coagulability is suspected as a link. Objective: To investigate the association between the severity of OSA and blood coagulability. Design, Setting, and Participants: A retrospective cohort study conducted at a tertiary care university hospital evaluated 146 patients with OSA from January 1, 2009, to July 31, 2015...
August 17, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28817421/association-of-stop-bang-questionnaire-as-a-screening-tool-for-sleep-apnea-and-postoperative-complications-a-systematic-review-and-bayesian-meta-analysis-of-prospective-and-retrospective-cohort-studies
#19
Mahesh Nagappa, Jayadeep Patra, Jean Wong, Yamini Subramani, Mandeep Singh, George Ho, David T Wong, Frances Chung
BACKGROUND: The risk of postoperative complications increases with undiagnosed obstructive sleep apnea (OSA). The high-risk OSA (HR-OSA) patients can be easily identified using the STOP-Bang screening tool. The aim of this systematic review and meta-analysis is to determine the association of postoperative complications in patients screened as HR-OSA versus low-risk OSA (LR-OSA). METHODS: The following data bases were searched from January 1, 2008, to October 31, 2016, to identify the eligible articles: Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, Cochrane Databases of Systematic Reviews, Medline-in-Process & other nonindexed citations, Google Scholar, Embase, Web of Sciences and Scopus...
August 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28816683/cardiorespiratory-model-based-data-driven-approach-for-sleep-apnea-detection
#20
Sandeep Gutta, Qi Cheng, Hoa Nguyen, Bruce Benjamin
Obstructive sleep apnea (OSA) is a chronic sleep disorder affecting millions of people worldwide. Individuals with OSA are rarely aware of the condition and are often left untreated, which can lead to some serious health problems. Nowadays, several low-cost wearable health sensors are available that can be used to conveniently and noninvasively collect a wide range of physiological signals. In this paper, we propose a new framework for OSA detection in which we combine the wearable sensor measurement signals with the mathematical models of the cardiorespiratory system...
August 14, 2017: IEEE Journal of Biomedical and Health Informatics
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