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Jun Hu, Xiaolei Wang, Tao Ai, Xiaoping Xie, Xiaoyun Liu, Huawei Liu, Lili Yang, Hua Li, Taoyi Yang, Tong Zhang, Li Zhang, Zhao Yang, Quanmin Deng
OBJECTIVE: To understand epidemiological characteristics of Haemophilus influenzae (Hi) infection in hospitalized children with lower respiratory tract infection (LRTI) in west Sichuan China. METHOD: The multicenter prospective cross-sectional design was used; four hospitals in west Sichuan China were chosen as research field, sputum bacterial culture was done and biological typing, PCR identification and drug sensitivity test of Hi epidemic strains were carried out among 0-17y hospitalized patients with LRTI in four hospitals located in west Sichuan China...
February 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Ravendra Garg, Pratima Shrivastava, Sylvia van Drunen Littel-van den Hurk
Respiratory syncytial virus (RSV) is a common human pathogen that causes cold-like symptoms in most healthy adults and children. However, RSV often moves into the lower respiratory tract in infants and young children predisposed to respiratory illness, making it the most common cause of pediatric broncheolitis and pneumonia. The development of an appropriate balanced immune response is critical for recovery from RSV, while an unbalanced and/or excessively vigorous response may lead to immunopathogenesis. Different dendritic cell (DC) subsets influence the magnitude and quality of the host response to RSV infection, with myeloid DCs mediating and plasmacytoid DCs modulating immunopathology...
December 2012: Expert Review of Vaccines
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