keyword
https://read.qxmd.com/read/38257787/safety-and-efficacy-upon-infection-in-sheep-with-rift-valley-fever-virus-zh548-ra2-a-triple-mutant-rescued-virus
#21
JOURNAL ARTICLE
Sandra Moreno, Gema Lorenzo, Álvaro López-Valiñas, Nuria de la Losa, Celia Alonso, Elena Charro, José I Núñez, Pedro J Sánchez-Cordón, Belén Borrego, Alejandro Brun
The introduction of three single nucleotide mutations into the genome of the virulent RVFV ZH548 strain allows for the rescue of a fully attenuated virus in mice (ZH548-rA2). These mutations are located in the viral genes encoding the RdRp and the non-structural protein NSs. This paper shows the results obtained after the subcutaneous inoculation of ZH548-rA2 in adult sheep and the subsequent challenge with the parental virus (ZH548-rC1). Inoculation with the ZH548-rA2 virus caused no detectable clinical or pathological effect in sheep, whereas inoculation of the parental rC1 virus caused lesions compatible with viral infection characterised by the presence of scattered hepatic necrosis...
January 5, 2024: Viruses
https://read.qxmd.com/read/38186208/zoonotic-risks-of-pathogens-from-dairy-cattle-and-their-milk-borne-transmission
#22
REVIEW
Menno Holzhauer, Gerrit Jan Wennink
Dairy products are major sources of high-quality protein and bioavailable nutrients and dairy production contributes to local, regional and national-level economies. Consumption of raw milk and raw milk products does, however, carry a zoonotic risk, as does direct contact with cattle by farm husbandry staff and other employees. This review will mainly focus on the latter, and deal with it from the standpoint of a well-developed dairy industry, using the example of the Netherlands. With regard to dairy cattle, the main bacterial pathogens are Salmonella spp...
January 8, 2024: Journal of Dairy Research
https://read.qxmd.com/read/38167250/correction-rift-valley-fever-outbreak-in-sembabule-district-uganda-december-2020
#23
Freda Loy Aceng, Joshua Kayiwa, Peter Elyanu, Joseph Ojwang, Luke Nyakarahuka, Stephen Balinandi, Jayne Byakika-Tusiime, Alfred Wejuli, Julie Rebecca Harris, John Opolot
No abstract text is available yet for this article.
January 2, 2024: One health outlook
https://read.qxmd.com/read/38140610/pathogenesis-of-rift-valley-fever-virus-in-a-balb-c-mouse-model-is-affected-by-virus-culture-conditions-and-sex-of-the-animals
#24
JOURNAL ARTICLE
Victoria A Graham, Linda Easterbrook, Emma Kennedy, Emma Rayner, Stephen Findlay-Wilson, Lucy Flett, Emma Louise Wise, Samantha Treagus, Susan Fotheringham, Sarah Kempster, Neil Almond, Stuart Dowall
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease in livestock and humans. Whilst initially restricted to the African continent, recent spread to the Arabian Peninsula has highlighted the likelihood of entry into new regions. Due to the absence of a regulatory-approved human vaccine, work is ongoing to develop and assess countermeasures. As such, small animal models play a pivotal role in providing information on disease pathogenesis and elucidating which intervention strategies confer protection...
November 30, 2023: Viruses
https://read.qxmd.com/read/38131795/rapid-on-site-detection-of-arboviruses-by-a-direct-rt-qpcr-assay
#25
JOURNAL ARTICLE
Moufid Mhamadi, Giulia Mencattelli, Alioune Gaye, El Hadji Ndiaye, Aïssatou Aïcha Sow, Martin Faye, Marie Henriette Dior Ndione, Moussa Moïse Diagne, Moundhir Mhamadi, Ousmane Faye, Manfred Weidmann, Oumar Faye, Mawlouth Diallo, Cheikh Tidiane Diagne
Arthropod-borne diseases currently constitute a source of major health concerns worldwide. They account for about 50% of global infectious diseases and cause nearly 700,000 deaths every year. Their rapid increase and spread constitute a huge challenge for public health, highlighting the need for early detection during epidemics, to curtail the virus spread, and to enhance outbreak management. Here, we compared a standard quantitative polymerase chain reaction (RT-qPCR) and a direct RT-qPCR assay for the detection of Zika (ZIKV), Chikungunya (CHIKV), and Rift Valley Fever (RVFV) viruses from experimentally infected-mosquitoes...
December 16, 2023: Biosensors
https://read.qxmd.com/read/38129678/limited-high-throughput-screening-compatibility-of-the-phenuivirus-cap-binding-domain
#26
JOURNAL ARTICLE
Janna Scherf, Dominik Vogel, Sheraz Gul, Jeanette Reinshagen, Philip Gribbon, Maria Rosenthal
Bunyaviruses constitute a large and diverse group of viruses encompassing many emerging pathogens, such as Rift Valley fever virus (family Phenuiviridae), with public and veterinary health relevance but with very limited medical countermeasures are available. For the development of antiviral strategies, the identification and validation of virus-specific targets would be of high value. The cap-snatching mechanism is an essential process in the life cycle of bunyaviruses to produce capped mRNAs, which are then recognized and translated into viral proteins by the host cell translation machinery...
December 20, 2023: Scientific Reports
https://read.qxmd.com/read/38127656/halogenated-rocaglate-derivatives-pan-antiviral-agents-against-hepatitis-e-virus-and-emerging-viruses
#27
JOURNAL ARTICLE
Catherine Victoria, Göran Schulz, Mara Klöhn, Saskia Weber, Cora M Holicki, Yannick Brüggemann, Miriam Becker, Gisa Gerold, Martin Eiden, Martin H Groschup, Eike Steinmann, Andreas Kirschning
The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4', 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol...
December 21, 2023: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38083993/first-detection-of-rift-valley-fever-virus-antibodies-in-non-human-primates-in-cameroon
#28
JOURNAL ARTICLE
Jean Thierry Ebogo-Belobo, Serge Alain Sadeuh-Mba, Gwladys Monamele Chavely, Martin H Groschup, Wilfred Fon Mbacham, Richard Njouom
We tested for Rift Valley fever virus (RVFV) from at least 15 species of non-human primates. RVFV IgG/IgM antibodies were detected in 3.7% (2 out of 53) of chimpanzees (Pan troglodytes) and in 1.4% (1 out of 72) of unidentified non-human primate species. This study was the first investigation of RVFV in monkeys in Cameroon.
December 11, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/38064029/reverse-genetics-system-for-rift-valley-fever-virus
#29
JOURNAL ARTICLE
Breanna Tercero, Shinji Makino
Rift Valley fever virus (RVFV) is an important mosquito-borne virus that can cause severe disease manifestations in humans including ocular damage, vision loss, late-onset encephalitis, and hemorrhagic fever. In ruminants, RVFV can cause high mortality rates in young animals and high rates of abortion in pregnant animals resulting in an enormous negative impact on the economy of affected regions. To date, no licensed vaccines in humans or anti-RVFV therapeutics for animal or human use are available. The development of reverse genetics has facilitated the generation of recombinant infectious viruses that serve as powerful tools for investigating the molecular biology and pathogenesis of RVFV...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38024279/prioritization-of-zoonoses-for-multisectoral-one-health-collaboration-in-somalia-2023
#30
JOURNAL ARTICLE
Abdinasir Yusuf Osman, Halima Mohamed, Farah I Mumin, Heba Mahrous, Asma Saidouni, Sharifo Ali Elmi, Amira Khalif Adawe, Abdikani Abdullahi Mo'allim, Mutaawe Lubogo, Sk Md Mamunur Rahman Malik, Athman Mwatondo, Tajudeen Raji, Abdifatah Dirie Ahmed, Alimuddin Zumla, Osman Dar, Richard Kock, Siobhan M Mor
BACKGROUND: The human population of Somalia is vulnerable to zoonoses due to a high reliance on animal husbandry. This disease risk is exacerbated by relatively low income (poverty) and weak state capacity for health service delivery in the country as well as climate extremes and geopolitical instability in the region. To address this threat to public health efficiently and effectively, it is essential that all sectors have a common understanding of the priority zoonotic diseases of greatest concern to the country...
December 2023: One Health
https://read.qxmd.com/read/38024257/zoonoses-research-in-somalia-a-scoping-review-using-a-one-health-approach
#31
REVIEW
Farah I Mumin, Andy Fenton, Abdinasir Yusuf Osman, Siobhan M Mor
Zoonoses are likely to cause a substantial burden on both human and animal health systems in Somalia, given the close proximity between the pastoralist majority and their livestock. However, decades of instability leading to weak disease surveillance have meant that data on the burden of zoonoses is lacking. The aim of this scoping review was to assess and synthesize the available literature on the presence and burden of zoonoses in Somalia. We used keywords to search Web of Science for relevant publications...
December 2023: One Health
https://read.qxmd.com/read/38019849/role-and-effectiveness-of-telephone-hotlines-in-outbreak-response-in-africa-a-systematic-review-and-meta-analysis
#32
JOURNAL ARTICLE
Noah T Fongwen, Almighty Nchafack, Hana Rohan, Jason J Ong, Joseph D Tucker, Nadine Beckmann, Gwenda Hughes, Rosanna W Peeling
BACKGROUND: In Africa, little is known about the role of telephone hotlines in outbreak response. We systematically reviewed the role and effectiveness of hotlines on outbreak response in Africa. METHOD: We used the Cochrane handbook and searched five databases. The protocol was registered on PROSPERO (CRD42021247141). Medline, Embase, PsycINFO, Global Health and Web of Science were searched from 30 June 2020 to August 2020 for studies on the use of telephone hotlines in outbreak response in Africa published between January 1995 and August 2020...
2023: PloS One
https://read.qxmd.com/read/38017028/author-correction-a-rift-valley-fever-mrna-vaccine-elicits-strong-immune-responses-in-mice-and-rhesus-macaques
#33
Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen
No abstract text is available yet for this article.
November 28, 2023: NPJ Vaccines
https://read.qxmd.com/read/38012800/rift-valley-fever-outbreak-in-sembabule-district-uganda-december-2020
#34
JOURNAL ARTICLE
Freda Loy Aceng, Joshua Kayiwa, Peter Elyanu, Joseph Ojwang, Luke Nyakarahuka, Stephen Balinandi, Jayne Byakika-Tusiime, Alfred Wejuli, Julie Rebecca Harris, John Opolot
BACKGROUND: Rift Valley Fever (RVF) is a viral zoonosis that can cause severe haemorrhagic fevers in humans and high mortality rates and abortions in livestock. On 10 December 2020, the Uganda Ministry of Health was notified of the death of a 25-year-old male who tested RVF-positive by reverse-transcription polymerase chain reaction (RT-PCR) at the Uganda Virus Research Institute. We investigated to determine the scope of the outbreak, identify exposure factors, and institute control measures...
November 27, 2023: One health outlook
https://read.qxmd.com/read/38005928/identification-of-host-factors-for-rift-valley-fever-phlebovirus
#35
JOURNAL ARTICLE
Velmurugan Balaraman, Sabarish V Indran, Yonghai Li, David A Meekins, Laxmi U M R Jakkula, Heidi Liu, Micheal P Hays, Jayme A Souza-Neto, Natasha N Gaudreault, Philip R Hardwidge, William C Wilson, Friedemann Weber, Juergen A Richt
Rift Valley fever phlebovirus (RVFV) is a zoonotic pathogen that causes Rift Valley fever (RVF) in livestock and humans. Currently, there is no licensed human vaccine or antiviral drug to control RVF. Although multiple species of animals and humans are vulnerable to RVFV infection, host factors affecting susceptibility are not well understood. To identify the host factors or genes essential for RVFV replication, we conducted CRISPR-Cas9 knockout screening in human A549 cells. We then validated the putative genes using siRNA-mediated knock-downs and CRISPR-Cas9-mediated knock-out studies...
November 13, 2023: Viruses
https://read.qxmd.com/read/38005861/a-novel-quadruple-gene-deleted-bohv-1-vectored-rvfv-subunit-vaccine-induces-humoral-and-cell-mediated-immune-response-against-rift-valley-fever-in-calves
#36
JOURNAL ARTICLE
Selvaraj Pavulraj, Rhett W Stout, Elise D Barras, Daniel B Paulsen, Shafiqul I Chowdhury
Rift Valley fever virus (RVFV) is considered to be a high biodefense priority based on its threat to livestock and its ability to cause human hemorrhagic fever. RVFV-infected livestock are also a significant risk factor for human infection by direct contact with contaminated blood, tissues, and aborted fetal materials. Therefore, livestock vaccination in the affected regions has the direct dual benefit and one-health approach of protecting the lives of millions of animals and eliminating the risk of severe and sometimes lethal human Rift Valley fever (RVF) disease...
October 30, 2023: Viruses
https://read.qxmd.com/read/38005818/-dishevelled-has-anti-viral-activity-in-rift-valley-fever-virus-infected-aedes-aegypti
#37
JOURNAL ARTICLE
Christian B Smith, Natasha F Hodges, Rebekah C Kading, Corey L Campbell
Mosquitoes in the genera Aedes and Culex are vectors of Rift Valley fever virus (RVFV), which emerges in periodic epidemics in Africa and Saudi Arabia. Factors that influence the transmission dynamics of RVFV are not well characterized. To address this, we interrogated mosquito host-signaling responses through analysis of differentially expressed genes (DEGs) in two mosquito species with marked differences in RVFV vector competence: Aedes aegypti ( Aae , low competence) and Culex tarsalis ( Cxt , high competence)...
October 24, 2023: Viruses
https://read.qxmd.com/read/38003834/arthropod-borne-viruses-in-mauritania-a-literature-review
#38
REVIEW
Abdallahi El Ghassem, Bedia Abdoullah, Jemila Deida, Mohamed Aly Ould Lemrabott, Mohamed Ouldabdallahi Moukah, Mohamed Salem Ould Ahmedou Salem, Sébastien Briolant, Leonardo K Basco, Khyarhoum Ould Brahim, Ali Ould Mohamed Salem Boukhary
During the past four decades, recurrent outbreaks of various arthropod-borne viruses have been reported in Mauritania. This review aims to consolidate the current knowledge on the epidemiology of the major arboviruses circulating in Mauritania. Online databases including PubMed and Web of Science were used to retrieve relevant published studies. The results showed that numerous arboviral outbreaks of variable magnitude occurred in almost all 13 regions of Mauritania, with Rift Valley fever (RVF), Crimean-Congo hemorrhagic fever (CCHF), and dengue (DEN) being the most common infections...
November 20, 2023: Pathogens
https://read.qxmd.com/read/37984160/participatory-survey-of-risk-factors-and-pathways-for-rift-valley-fever-in-pastoral-and-agropastoral-communities-of-uganda
#39
JOURNAL ARTICLE
Dan Tumusiime, Ard M Nijhof, Martin H Groschup, Julius Lutwama, Kristina Roesel, Bernard Bett
To assess pastoralists' and agropastoralists' knowledge on Rift Valley fever (RVF), participatory epidemiological studies were conducted with 215 livestock keepers and 27 key informants in Napak, Butebo, Isingiro and Lyantonde districts, Uganda, between January and February 2022. Livestock keepers in all four districts had knowledge of RVF and even had local names or descriptions for it. Pastoralists and agropastoralists possessed valuable knowledge of RVF clinical descriptions and epidemiological risk factors such as the presence of infected mosquitoes, living in flood-prone areas, and excessive rainfall...
November 8, 2023: Preventive Veterinary Medicine
https://read.qxmd.com/read/37929289/zoonotic-diseases-transmitted-from-the-camels
#40
REVIEW
Abdelmalik Ibrahim Khalafalla
BACKGROUND: Zoonotic diseases, infections transmitted naturally from animals to humans, pose a significant public health challenge worldwide. After MERS-CoV was discovered, interest in camels was raised as potential intermediate hosts for zoonotic viruses. Most published review studies pay little attention to case reports or zoonotic epidemics where there is epidemiological proof of transmission from camels to humans. Accordingly, any pathogen found in camels known to cause zoonotic disease in other animals or humans is reported...
2023: Frontiers in Veterinary Science
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