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Rift valley fever

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https://www.readbyqxmd.com/read/27872619/ebola-vp40-in-exosomes-can-cause-immune-cell-dysfunction
#1
Michelle L Pleet, Allison Mathiesen, Catherine DeMarino, Yao A Akpamagbo, Robert A Barclay, Angela Schwab, Sergey Iordanskiy, Gavin C Sampey, Benjamin Lepene, Sergei Nekhai, M J Aman, Fatah Kashanchi
Ebola virus (EBOV) is an enveloped, ssRNA virus from the family Filoviridae capable of causing severe hemorrhagic fever with up to 80-90% mortality rates. The most recent outbreak of EBOV in West Africa starting in 2014 resulted in over 11,300 deaths; however, long-lasting persistence and recurrence in survivors has been documented, potentially leading to further transmission of the virus. We have previously shown that exosomes from cells infected with HIV-1, HTLV-1 and Rift Valley Fever virus are able to transfer viral proteins and non-coding RNAs to naïve recipient cells, resulting in an altered cellular activity...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27869589/rift-valley-fever-outbreak-in-livestock-mozambique-2014
#2
José M Fafetine, Peter Coetzee, Benjamin Mubemba, Ofélia Nhambirre, Luis Neves, J A W Coetzer, Estelle H Venter
In early 2014, abortions and death of ruminants were reported on farms in Maputo and Gaza Provinces, Mozambique. Serologic analysis and quantitative and conventional reverse transcription PCR confirmed the presence of Rift Valley fever virus. The viruses belonged to lineage C, which is prevalent among Rift Valley fever viruses in southern Africa.
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27863533/ecological-niche-modelling-of-rift-valley-fever-virus-vectors-in-baringo-kenya
#3
Alfred O Ochieng, Mark Nanyingi, Edwin Kipruto, Isabella M Ondiba, Fred A Amimo, Christopher Oludhe, Daniel O Olago, Isaac K Nyamongo, Benson B A Estambale
BACKGROUND: Rift Valley fever (RVF) is a vector-borne zoonotic disease that has an impact on human health and animal productivity. Here, we explore the use of vector presence modelling to predict the distribution of RVF vector species under climate change scenario to demonstrate the potential for geographic spread of Rift Valley fever virus (RVFV). OBJECTIVES: To evaluate the effect of climate change on RVF vector distribution in Baringo County, Kenya, with an aim of developing a risk map for spatial prediction of RVF outbreaks...
2016: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/27844026/severe-human-illness-caused-by-rift-valley-fever-virus-in-mauritania-2015
#4
Boushab Mohamed Boushab, Fatima Zahra Fall-Malick, Sidi El Wafi Ould Baba, Mohamed Lemine Ould Salem, Marie Roseline Darnycka Belizaire, Hamade Ledib, Mohamed Mahmoud Ould Baba Ahmed, Leonardo Kishi Basco, Hampaté Ba
BACKGROUND: Rift Valley Fever epizootics are characterized by numerous abortions and mortality among young animals. In humans, the illness is usually characterized by a mild self-limited febrile illness, which could progress to more serious complications.Objectives. The aim of the present prospective study was to describe severe clinical signs and symptoms of Rift Valley Fever in southern Mauritania. PATIENTS AND METHODS: Suspected cases were enrolled in Kiffa (Assaba) and Aleg (Brakna) Hospital Centers from September 1 to November 7, 2015, based on the presence of fever, hemorrhagic or meningoencephalitic syndromes, and probable contact with sick animals...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27830387/public-health-benefits-from-livestock-rift-valley-fever-control-a-simulation-of-two-epidemics-in-kenya
#5
Tabitha Kimani, Esther Schelling, Bernard Bett, Margaret Ngigi, Tom Randolph, Samuel Fuhrimann
In controlling Rift Valley fever, public health sector optimises health benefits by considering cost-effective control options. We modelled cost-effectiveness of livestock RVF control from a public health perspective in Kenya. Analysis was limited to pastoral and agro-pastoral system high-risk areas, for a 10-year period incorporating two epidemics: 2006/2007 and a hypothetical one in 2014/2015. Four integrated strategies (baseline and alternatives), combined from three vaccination and two surveillance options, were compared...
November 9, 2016: EcoHealth
https://www.readbyqxmd.com/read/27822717/import-of-rift-valley-fever-to-china-a-potential-new-threat
#6
Xinliang Fu, Lifang Wang, Bo Fang, Ruirui Ma, Yun Zheng, San Huang, Pei Zhou, Zongxi Cao, Jin Tian, Shoujun Li, Guihong Zhang
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27811840/notes-from-the-field-rift-valley-fever-response-kabale-district-uganda-march-2016
#7
Annabelle de St Maurice, Luke Nyakarahuka, Lawrence Purpura, Elizabeth Ervin, Alex Tumusiime, Stephen Balinandi, Jackson Kayondo, Sophia Mulei, Anne Marion Namutebi, Patrick Tusiime, Steven Wiersma, Stuart Nichol, Pierre Rollin, John Klena, Barbara Knust, Trevor Shoemaker
On March 9, 2016, a male butcher from Kabale District, Uganda, aged 45 years, reported to the Kabale Regional Referral Hospital with fever, fatigue, and headache associated with black tarry stools and bleeding from the nose. One day later, a student aged 16 years from a different sub-county in Kabale District developed similar symptoms and was admitted to the same hospital. The student also had a history of contact with livestock. Blood specimens collected from both patients were sent for testing for Marburg virus disease, Ebola virus disease, Rift Valley fever (RVF), and Crimean Congo Hemorrhagic fever at the Uganda Virus Research Institute, as part of the viral hemorrhagic fevers surveillance program...
November 4, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27783673/crystal-structure-of-glycoprotein-c-from-a-hantavirus-in-the-post-fusion-conformation
#8
Shmuel Willensky, Hagit Bar-Rogovsky, Eduardo A Bignon, Nicole D Tischler, Yorgo Modis, Moshe Dessau
Hantaviruses are important emerging human pathogens and are the causative agents of serious diseases in humans with high mortality rates. Like other members in the Bunyaviridae family their M segment encodes two glycoproteins, GN and GC, which are responsible for the early events of infection. Hantaviruses deliver their tripartite genome into the cytoplasm by fusion of the viral and endosomal membranes in response to the reduced pH of the endosome. Unlike phleboviruses (e.g. Rift valley fever virus), that have an icosahedral glycoprotein envelope, hantaviruses display a pleomorphic virion morphology as GN and GC assemble into spikes with apparent four-fold symmetry organized in a grid-like pattern on the viral membrane...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27771072/mouse-model-for-the-rift-valley-fever-virus-mp12-strain-infection
#9
Yuekun Lang, Jamie Henningson, Dane Jasperson, Yonghai Li, Jinhwa Lee, Jingjiao Ma, Yuhao Li, Nan Cao, Haixia Liu, William Wilson, Juergen Richt, Mark Ruder, Scott McVey, Wenjun Ma
Rift Valley fever virus (RVFV), a Category A pathogen and select agent, is the causative agent of Rift Valley fever. To date, no fully licensed vaccine is available in the U.S. for human or animal use and effective antiviral drugs have not been identified. The RVFV MP12 strain is conditionally licensed for use for veterinary purposes in the U.S. which was excluded from the select agent rule of Health and Human Services and the U.S. Department of Agriculture. The MP12 vaccine strain is commonly used in BSL-2 laboratories that is generally not virulent in mice...
November 15, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27760144/rift-valley-fever-virus-circulating-among-ruminants-mosquitoes-and-humans-in-the-central-african-republic
#10
Emmanuel Nakouné, Basile Kamgang, Nicolas Berthet, Alexandre Manirakiza, Mirdad Kazanji
BACKGROUND: Rift Valley fever virus (RVFV) causes a viral zoonosis, with discontinuous epizootics and sporadic epidemics, essentially in East Africa. Infection with this virus causes severe illness and abortion in sheep, goats, and cattle as well as other domestic animals. Humans can also be exposed through close contact with infectious tissues or by bites from infected mosquitoes, primarily of the Aedes and Culex genuses. Although the cycle of RVFV infection in savannah regions is well documented, its distribution in forest areas in central Africa has been poorly investigated...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27716429/serosurveillance-of-viral-pathogens-circulating-in-west-africa
#11
Aileen E O'Hearn, Matthew A Voorhees, David P Fetterer, Nadia Wauquier, Moinya R Coomber, James Bangura, Joseph N Fair, Jean-Paul Gonzalez, Randal J Schoepp
BACKGROUND: Sub-Saharan Africa is home to a variety of pathogens, but disease surveillance and the healthcare infrastructure necessary for proper management and control are severely limited. Lassa virus, the cause of Lassa fever, a severe hemorrhagic fever in humans is endemic in West Africa. In Sierra Leone at the Kenema Government Hospital Lassa Diagnostic Laboratory, up to 70 % of acute patient samples suspected of Lassa fever test negative for Lassa virus infection. This large amount of acute undiagnosed febrile illness can be attributed in part to an array of hemorrhagic fever and arthropod-borne viruses causing disease that goes undetected and untreated...
October 3, 2016: Virology Journal
https://www.readbyqxmd.com/read/27711108/mechanistic-insight-into-the-host-transcription-inhibition-function-of-rift-valley-fever-virus-nss-and-its-importance-in-virulence
#12
Kaori Terasaki, Sydney I Ramirez, Shinji Makino
Rift Valley fever virus (RVFV), a member of the genus Phlebovirus within the family Bunyaviridae, causes periodic outbreaks in livestocks and humans in countries of the African continent and Middle East. RVFV NSs protein, a nonstructural protein, is a major virulence factor that exhibits several important biological properties. These include suppression of general transcription, inhibition of IFN-β promoter induction and degradation of double-stranded RNA-dependent protein kinase R. Although each of these biological functions of NSs are considered important for countering the antiviral response in the host, the individual contributions of these functions towards RVFV virulence remains unclear...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27707507/rift-valley-fever-trasmission-dynamics-described-by-compartmental-models
#13
Maria Luisa Danzetta, Rossana Bruno, Francesca Sauro, Lara Savini, Paolo Calistri
Rift Valley fever (RVF) is one of the most important zoonotic Transboundary Animal Diseases able to cross international borders and cause devastating effect on animal health and food security. Climate changes and the presence of competent vectors in the most of the current RVF-free temperate countries strongly support the inclusion of RVF virus (RVFV) among the most significant emerging viral threats for public and animal health. The transmission of RVFV is driven by complex eco-climatic factors making the epidemiology of RVF infection difficult to study and to understand...
September 11, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27704007/widespread-rift-valley-fever-emergence-in-senegal-in-2013-2014
#14
Abdourahmane Sow, Ousmane Faye, Yamar Ba, Diawo Diallo, Gamou Fall, Oumar Faye, Ndeye Sakha Bob, Cheikh Loucoubar, Vincent Richard, Anta Tal Dia, Mawlouth Diallo, Denis Malvy, Amadou Alpha Sall
Rift Valley fever (RVF), which caused epizootics and epidemics among human and livestock populations, occurred in Senegal in 2013-2014. A multidisciplinary field investigation was carried out in 3 regions of Senegal. We found 11 confirmed human cases of Rift Valley fever, including severe cases with encephalitis and retinitis, 1 pool of mosquito (Aedes ochraceus), and 52 animals tested positive for the disease. Symptoms such as encephalitis and macular retinitis were the most severe cases reported so far in Senegal...
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27692776/association-of-rift-valley-fever-virus-infection-with-miscarriage-in-sudanese-women-a-cross-sectional-study
#15
Maria Baudin, Ammar M Jumaa, Huda J E Jomma, Mubarak S Karsany, Göran Bucht, Jonas Näslund, Clas Ahlm, Magnus Evander, Nahla Mohamed
BACKGROUND: Rift Valley fever virus is an emerging mosquito-borne virus that causes infections in animals and human beings in Africa and the Arabian Peninsula. Outbreaks of Rift Valley fever lead to mass abortions in livestock, but such abortions have not been identified in human beings. Our aim was to investigate the cause of miscarriages in febrile pregnant women in an area endemic for Rift Valley fever. METHODS: Pregnant women with fever of unknown origin who attended the governmental hospital of Port Sudan, Sudan, between June 30, 2011, and Nov 17, 2012, were sampled at admission and included in this cross-sectional study...
November 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27692775/rift-valley-fever-still-an-emerging-infection-after-3500-years
#16
Ali S Khan, Carl V Smith
No abstract text is available yet for this article.
November 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27689098/safety-and-efficacy-profile-of-commercial-veterinary-vaccines-against-rift-valley-fever-a-review-study
#17
Moataz Alhaj
Rift Valley Fever (RVF) is an infectious illness with serious clinical manifestations and health consequences in humans as well as a wide range of domestic ruminants. This review provides significant information about the prevention options of RVF along with the safety-efficacy profile of commercial vaccines and some of RVF vaccination strategies. Information presented in this paper was obtained through a systematic investigation of published data about RVF vaccines. Like other viral diseases, the prevention of RVF relies heavily on immunization of susceptible herds with safe and cost-effective vaccine that is able to confer long-term protective immunity...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27662585/biologically-informed-individual-based-network-model-for-rift-valley-fever-in-the-us-and-evaluation-of-mitigation-strategies
#18
Caterina M Scoglio, Claudio Bosca, Mahbubul H Riad, Faryad D Sahneh, Seth C Britch, Lee W Cohnstaedt, Kenneth J Linthicum
Rift Valley fever (RVF) is a zoonotic disease endemic in sub-Saharan Africa with periodic outbreaks in human and animal populations. Mosquitoes are the primary disease vectors; however, Rift Valley fever virus (RVFV) can also spread by direct contact with infected tissues. The transmission cycle is complex, involving humans, livestock, and multiple species of mosquitoes. The epidemiology of RVFV in endemic areas is strongly affected by climatic conditions and environmental variables. In this research, we adapt and use a network-based modeling framework to simulate the transmission of RVFV among hypothetical cattle operations in Kansas, US...
2016: PloS One
https://www.readbyqxmd.com/read/27651156/structural-and-practical-identifiability-issues-of-immuno-epidemiological-vector-host-models-with-application-to-rift-valley-fever
#19
Necibe Tuncer, Hayriye Gulbudak, Vincent L Cannataro, Maia Martcheva
In this article, we discuss the structural and practical identifiability of a nested immuno-epidemiological model of arbovirus diseases, where host-vector transmission rate, host recovery, and disease-induced death rates are governed by the within-host immune system. We incorporate the newest ideas and the most up-to-date features of numerical methods to fit multi-scale models to multi-scale data. For an immunological model, we use Rift Valley Fever Virus (RVFV) time-series data obtained from livestock under laboratory experiments, and for an epidemiological model we incorporate a human compartment to the nested model and use the number of human RVFV cases reported by the CDC during the 2006-2007 Kenya outbreak...
September 2016: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/27642413/-severe-hemorrhagic-forms-of-rift-valley-fever-about-5-cases
#20
Mohamed Lemine Ould Salem, Sidi El Wafi Ould Baba, Fatimetou Zahra Fall-Malick, Boushab Mohamed Boushab, Sidi Mohamed Ghaber, Abdelwedoud Mokhtar
Rift Valley fever (RVF) is an arbovirus caused by an RNA virus belonging to family Bunyaviridae (genus phlebovirus). It is a zoonosis that primarily affects animals but it also has the capacity to infect humans, either by handling meat, runts of sick animals or, indirectly, by the bite of infected mosquitoes (Aedes sp, Anopheles sp, Culex sp). In most cases, RVF infection in humans is asymptomatic, but it can also manifest as moderate febrile syndrome with a favorable outcome. However, some patients may develop hemorrhagic syndrome and/or neurological damages with a fatal evolution...
2016: Pan African Medical Journal
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