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Rift valley fever

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https://www.readbyqxmd.com/read/28918558/colorimetric-detection-of-unamplified-rift-valley-fever-virus-genetic-material-using-unmodified-gold-nanoparticles
#1
Mostafa R Zaher, Hanaa A Ahmed, Kareem E Z Hamada, Reham H Tammam
Rift Valley fever virus (RVFV) is considered an enzootic virus in Africa. RVFV has caused several outbreaks in Egypt, sub-Saharan Africa and the Arabian Peninsula and is responsible for high mortality in ruminants and haemorrhagic fever in severe human cases. Although there are several molecular and serological diagnostic techniques used to detect this arthropod-borne virus with high sensitivity and efficiency, there is a need for a fast and reliable field screening test for rapid outbreak recording and containment...
September 16, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28915104/rift-valley-fever-phlebovirus-nss-protein-core-domain-structure-suggests-molecular-basis-for-nuclear-filaments
#2
Michal Barski, Benjamin Brennan, Ona K Miller, Jane A Potter, Swetha Vijayakrishnan, David Bhella, James H Naismith, Richard M Elliott, Ulrich Schwarz-Linek
Rift Valley fever phlebovirus (RVFV) is a clinically and economically important pathogen increasingly likely to cause widespread epidemics. RVFV virulence depends on the interferon antagonist non-structural protein (NSs), which remains poorly characterized. We identified a stable core domain of RVFV NSs (residues 83-248), and solved its crystal structure, a novel all-helical fold organized into highly ordered fibrils. A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting it contains all essential determinants for nuclear translocation and filament formation...
September 15, 2017: ELife
https://www.readbyqxmd.com/read/28867393/reprint-of-epidemiology-of-brucellosis-q-fever-and-rift-valley-fever-at-the-human-and-livestock-interface-in-northern-c%C3%A3-te-d-ivoire
#3
Youssouf B Kanouté, Biégo G Gragnon, Christian Schindler, Bassirou Bonfoh, Esther Schelling
Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cross-sectional cluster surveys in livestock and humans between 2012 and 2014 in a random selection of 63 villages and a sample of 633 cattle, 622 small ruminants and 88 people. We administered questionnaires to capture risk factors and performed serological tests including the Rose Bengal Plate Test (RBPT), Brucella spp...
September 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28861841/the-first-serological-evidence-for-rift-valley-fever-infection-in-the-camel-goitered-gazelle-and-anatolian-water-buffaloes-in-turkey
#4
Sibel Gür, Mehmet Kale, Nural Erol, Orhan Yapici, Nuri Mamak, Sibel Yavru
Rift valley fever (RVF), a vector-borne zoonotic disease, is caused by a phlebovirus (family Bunyaviridae). The virus was initially characterized approximately 80 years ago in Kenya and disseminated to many countries in the continental Africa, Saudi Arabia, and Yemen. The infection has not been reported in Turkey. In this study, blood serum samples collected from camel (Camelus dromedairus), goitered gazelle (Gazella subgutturosa subgutturosa), and buffaloes (Bubalus bubalis linneaus) from 2000 to 2006 were investigated for RVF using C-ELISA...
August 31, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28854793/nss-protein-of-severe-fever-with-thrombocytopenia-syndrome-virus-suppresses-interferon-production-through-different-mechanism-than-rift-valley-fever-virus
#5
S Zhang, B Zheng, T Wang, A Li, J Wan, J Qu, C H Li, D Li, M Liang
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified Phlebovirus that causes severe fever with thrombocytopenia syndrome. Our study demonstrated that SFTSV NSs functioned as IFN antagonist mainly by suppressing TBK1/IKKε-IRF3 signaling pathway. NSs interacted with and relocalized TANK-binding kinase 1 (TBK1) into NSs-induced cytoplasmic structures and this interaction could effectively inhibit downstream phosphorylation and dimerization of interferon regulatory factor 3 (IRF3), resulting in the suppression of antiviral signaling and IFN induction...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28846489/zika-chikungunya-and-other-emerging-vector-borne-viral-diseases
#6
Scott C Weaver, Caroline Charlier, Nikos Vasilakis, Marc Lecuit
Arthropod-borne viruses (arboviruses) have a long history of emerging to infect humans, but during recent decades, they have been spreading more widely and affecting larger populations. This is due to several factors, including increased air travel and uncontrolled mosquito vector populations. Emergence can involve simple spillover from enzootic (wildlife) cycles, as in the case of West Nile virus accompanying geographic expansion into the Americas; secondary amplification in domesticated animals, as seen with Japanese encephalitis, Venezuelan equine encephalitis, and Rift Valley fever viruses; and urbanization, in which humans become the amplification hosts and peridomestic mosquitoes, mainly Aedes aegypti, mediate human-to-human transmission...
August 28, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28827346/structures-of-phlebovirus-glycoprotein-gn-and-identification-of-a-neutralizing-antibody-epitope
#7
Yan Wu, Yaohua Zhu, Feng Gao, Yongjun Jiao, Babayemi O Oladejo, Yan Chai, Yuhai Bi, Shan Lu, Mengqiu Dong, Chang Zhang, Guangmei Huang, Gary Wong, Na Li, Yanfang Zhang, Yan Li, Wen-Hai Feng, Yi Shi, Mifang Liang, Rongguang Zhang, Jianxun Qi, George F Gao
Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus (RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause severe illness in humans and animals. Glycoprotein N (Gn) is one of the envelope proteins on the virus surface and is a major antigenic component. Despite its importance for virus entry and fusion, the molecular features of the phleboviruse Gn were unknown. Here, we present the crystal structures of the Gn head domain from both SFTSV and RVFV, which display a similar compact triangular shape overall, while the three subdomains (domains I, II, and III) making up the Gn head display different arrangements...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807043/an-equine-herpesvirus-type-1-ehv-1-vector-expressing-rift-valley-fever-virus-rvfv-gn-and-gc-induces-neutralizing-antibodies-in-sheep
#8
Abdelrahman Said, Mona Elmanzalawy, Guanggang Ma, Armando Mario Damiani, Nikolaus Osterrieder
Rift Valley fever virus (RVFV) is an arthropod-borne bunyavirus that can cause serious and fatal disease in humans and animals. RVFV is a negative-sense RNA virus of the Phlebovirus genus in the Bunyaviridae family. The main envelope RVFV glycoproteins, Gn and Gc, are encoded on the M segment of RVFV and known inducers of protective immunity. In an attempt to develop a safe and efficacious RVF vaccine, we constructed and tested a vectored equine herpesvirus type 1 (EHV-1) vaccine that expresses RVFV Gn and Gc...
August 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28794043/sorafenib-impedes-rift-valley-fever-virus-egress-by-inhibiting-valosin-containing-protein-function-in-the-cellular-secretory-pathway
#9
Ashwini Brahms, Rajini Mudhasani, Chelsea Pinkham, Krishna Kota, Farooq Nassar, Rouzbeh Zamani, Sina Bavari, Kylene Kehn-Hall
There is an urgent need for therapeutic development to combat Rift Valley fever virus (RVFV) infections, which causes devastating disease in both humans and animals. In an effort to repurpose drugs for RVFV treatment, our previous studies screened a library of FDA-approved drugs. The most promising candidate identified was the hepatocellular and renal cell carcinoma drug, sorafenib. Mechanism of action studies indicated sorafenib targeted a late stage in virus infection and caused a buildup of virions within cells...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28782121/rift-valley-fever-virus-and-european-mosquitoes-vector-competence-of-culex-pipiens-and-stegomyia-albopicta-%C3%A2-aedes-albopictus
#10
M Brustolin, S Talavera, A Nuñez, C Santamaría, R Rivas, N Pujol, M Valle, M Verdún, A Brun, N Pagès, N Busquets
Rift Valley fever (RVF) is a mosquito-borne disease caused by the Rift Valley fever virus (RVFV). Rift Valley fever affects a large number of species, including human, and has severe impact on public health and the economy, especially in African countries. The present study examined the vector competence of three different European mosquito species, Culex pipiens (Linnaeus, 1758) form molestus (Diptera: Culicidae), Culex pipiens hybrid form and Stegomyia albopicta (= Aedes albopictus) (Skuse, 1894) (Diptera: Culicidae)...
August 7, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28769107/innate-immune-basis-for-rift-valley-fever-susceptibility-in-mouse-models
#11
Rashida Lathan, Dominique Simon-Chazottes, Grégory Jouvion, Ophélie Godon, Marie Malissen, Marie Flamand, Pierre Bruhns, Jean-Jacques Panthier
Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the immune basis for the extreme susceptibility of MBT/Pas mice that die with mild to acute hepatitis by day 3 post-infection compared to more resistant BALB/cByJ mice that survive up to a week longer. Lower levels of neutrophils observed in the bone marrow and blood of infected MBT/Pas mice are unlikely to be causative of increased RVFV susceptibility as constitutive neutropenia in specific mutant mice did not change survival outcome...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28742814/wetlands-wild-bovidae-species-richness-and-sheep-density-delineate-risk-of-rift-valley-fever-outbreaks-in-the-african-continent-and-arabian-peninsula
#12
Michael G Walsh, Allard Willem de Smalen, Siobhan M Mor
Rift Valley fever (RVF) is an emerging, vector-borne viral zoonosis that has significantly impacted public health, livestock health and production, and food security over the last three decades across large regions of the African continent and the Arabian Peninsula. The potential for expansion of RVF outbreaks within and beyond the range of previous occurrence is unknown. Despite many large national and international epidemics, the landscape epidemiology of RVF remains obscure, particularly with respect to the ecological roles of wildlife reservoirs and surface water features...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28733024/ecohealth-research-in-africa-where-from-where-to
#13
EDITORIAL
Robert Bergquist, Norbert W Brattig, Moses J Chimbari, Jakob Zinsstag, Jürg Utzinger
Epidemiological mapping and risk profiling build on the idea that diseases are tied to social-ecological systems that govern the distribution and abundance of transmissible pathogens, vectors and hosts. This is the heart of the emerging field of ecohealth, which examines how biological, cultural, demographic, economic, physical, political and social environments change can affect the health and wellbeing of humans, animals and ecosystems and the services they provide. This paper is an overview of a special issue of Acta Tropica, whose 15 publications reflect a geographically and epidemiologically diverse landscape of ecohealth in Africa...
July 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28732006/drivers-for-rift-valley-fever-emergence-in-mayotte-a-bayesian-modelling-approach
#14
Raphaëlle Métras, Guillaume Fournié, Laure Dommergues, Anton Camacho, Lisa Cavalerie, Philippe Mérot, Matt J Keeling, Catherine Cêtre-Sossah, Eric Cardinale, W John Edmunds
Rift Valley fever (RVF) is a major zoonotic and arboviral hemorrhagic fever. The conditions leading to RVF epidemics are still unclear, and the relative role of climatic and anthropogenic factors may vary between ecosystems. Here, we estimate the most likely scenario that led to RVF emergence on the island of Mayotte, following the 2006-2007 African epidemic. We developed the first mathematical model for RVF that accounts for climate, animal imports and livestock susceptibility, which is fitted to a 12-years dataset...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28727779/contemporary-status-of-insecticide-resistance-in-the-major-aedes-vectors-of-arboviruses-infecting-humans
#15
REVIEW
Catherine L Moyes, John Vontas, Ademir J Martins, Lee Ching Ng, Sin Ying Koou, Isabelle Dusfour, Kamaraju Raghavendra, João Pinto, Vincent Corbel, Jean-Philippe David, David Weetman
Both Aedes aegytpi and Ae. albopictus are major vectors of 5 important arboviruses (namely chikungunya virus, dengue virus, Rift Valley fever virus, yellow fever virus, and Zika virus), making these mosquitoes an important factor in the worldwide burden of infectious disease. Vector control using insecticides coupled with larval source reduction is critical to control the transmission of these viruses to humans but is threatened by the emergence of insecticide resistance. Here, we review the available evidence for the geographical distribution of insecticide resistance in these 2 major vectors worldwide and map the data collated for the 4 main classes of neurotoxic insecticide (carbamates, organochlorines, organophosphates, and pyrethroids)...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28719329/rift-valley-fever-seroprevalence-in-coastal-kenya
#16
COMPARATIVE STUDY
Elysse N Grossi-Soyster, Tamara Banda, Crystal Y Teng, Eric M Muchiri, Peter L Mungai, Francis M Mutuku, Ginny Gildengorin, Uriel Kitron, Charles H King, A Desiree Labeaud
Rift Valley fever virus (RVFV) causes severe disease in both animals and humans, resulting in significant economic and public health damages. The objective of this study was to measure RVFV seroprevalence in six coastal Kenyan villages between 2009 and 2011, and characterize individual-, household-, and community-level risk factors for prior RVFV exposure. Sera were tested for anti-RVFV IgG via enzyme-linked immunosorbent assay. Overall, 51 (1.8%; confidence interval [CI95] 1.3-2.3) of 2,871 samples were seropositive for RVFV...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719317/climate-influence-on-emerging-risk-areas-for-rift-valley-fever-epidemics-in-tanzania
#17
Clement N Mweya, Leonard E G Mboera, Sharadhuli I Kimera
Rift Valley Fever (RVF) is a climate-related arboviral infection of animals and humans. Climate is thought to represent a threat toward emerging risk areas for RVF epidemics globally. The objective of this study was to evaluate influence of climate on distribution of suitable breeding habitats for Culex pipiens complex, potential mosquito vector responsible for transmission and distribution of disease epidemics risk areas in Tanzania. We used ecological niche models to estimate potential distribution of disease risk areas based on vectors and disease co-occurrence data approach...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28710814/inter-epidemic-rift-valley-fever-virus-seroconversions-in-an-irrigation-scheme-in-bura-south-east-kenya
#18
D Mbotha, B Bett, S Kairu-Wanyoike, D Grace, A Kihara, M Wainaina, A Hoppenheit, P-H Clausen, J Lindahl
Rift Valley fever (RVF) is an acute mosquito-borne viral zoonosis whose outbreaks are often associated with prolonged rainfall and flooding, during which large numbers of vectors emerge. Recent studies into the inter-epidemic maintenance of RVF virus (RVFV) suggest that both vertical transmission in vectors and direct transmission between hosts act in combination with predisposing factors for persistence of the virus. A comparative longitudinal survey was carried out in Tana River County, Kenya, in irrigated, riverine and pastoral ecosystems from September 2014-June 2015...
July 14, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28693302/packaging-of-rvfv-pseudoviruses-and-establishment-of-a-neutralization-assay-method
#19
Yuetao Li, Yongkun Zhao, Cuiling Wang, Xuexing Zheng, Hualei Wang, Weiwei Gai, Hongli Jin, Feihu Yan, Boning Qiu, Yuwei Gao, Nan Li, Songtao Yang, Xianzhu Xia
Rift Valley fever (RVF) is an acute, febrile zoonotic disease that is caused by the RVF virus (RVFV). RVF is mainly prevalent on the Arabian Peninsula, the African continent, and several islands in the Indian Ocean near southeast Africa. RVFV has been classified by the World Organisation for Animal Health (OIE) as a category A pathogen. To avoid the biological safety concerns associated with use of the pathogen in RVFV neutralization assays, the present study explored and established an RVFV pseudovirus-based neutralization assay...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28686589/the-sero-epidemiology-of-rift-valley-fever-in-people-in-the-lake-victoria-basin-of-western-kenya
#20
Elizabeth Anne Jessie Cook, Elysse Noel Grossi-Soyster, William Anson de Glanville, Lian Francesca Thomas, Samuel Kariuki, Barend Mark de Clare Bronsvoort, Claire Njeri Wamae, Angelle Desiree LaBeaud, Eric Maurice Fèvre
Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample from western Kenya and compare this with slaughterhouse workers in the same region who are considered a high-risk group for RVFV exposure. The study was conducted in western Kenya between July 2010 and November 2012. Individuals were recruited from randomly selected homesteads and a census of slaughterhouses...
July 2017: PLoS Neglected Tropical Diseases
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