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Rift valley fever

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https://www.readbyqxmd.com/read/29155823/development-and-preliminary-evaluation-of-a-multiplexed-amplification-and-next-generation-sequencing-method-for-viral-hemorrhagic-fever-diagnostics
#1
Annika Brinkmann, Koray Ergünay, Aleksandar Radonić, Zeliha Kocak Tufan, Cristina Domingo, Andreas Nitsche
BACKGROUND: We describe the development and evaluation of a novel method for targeted amplification and Next Generation Sequencing (NGS)-based identification of viral hemorrhagic fever (VHF) agents and assess the feasibility of this approach in diagnostics. METHODOLOGY: An ultrahigh-multiplex panel was designed with primers to amplify all known variants of VHF-associated viruses and relevant controls. The performance of the panel was evaluated via serially quantified nucleic acids from Yellow fever virus, Rift Valley fever virus, Crimean-Congo hemorrhagic fever (CCHF) virus, Ebola virus, Junin virus and Chikungunya virus in a semiconductor-based sequencing platform...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29128744/comparison-of-two-zoonotic-viruses-from-the-order-bunyavirales
#2
REVIEW
Leela E Noronha, William C Wilson
A comparison of two geographicallly distinct viruses in the order Bunyavirales that are zoonotic and known to cause congenital abnormalities in ruminant livestock was performed. One of these viruses, Cache Valley fever virus, is found in the Americas and is primarily associated with disease in sheep. The other, Rift Valley fever virus, is found in Sub-Saharan Africa and is associated with disease in camels, cattle, goats and sheep. Neither virus has been associated with teratogenicity in humans to date. These two viruses are briefly reviewed and potential for genetic changes especially if introduced into new ecology that could affect pathogenicity are discussed...
November 9, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29118186/identification-of-phlebovirus-and-arenavirus-rna-sequences-that-stall-and-repress-the-exoribonuclease-xrn1
#3
Phillida A Charley, Carol J Wilusz, Jeffrey Wilusz
Regulated mRNA decay plays a vital role in determining both the level and quality of cellular gene expression. Viral RNAs must successfully evade this host RNA decay machinery to establish a productive infection. One way for RNA viruses to accomplish this is to target the cellular exoribonuclease XRN1, since this enzyme is accessible in the cytoplasm and plays a major role in mRNA decay. Members of the Flaviviridae use RNA structures in their 5' or 3' untranslated regions to stall and repress XRN1, effectively stabilizing viral RNAs while also causing significant dysregulation of host cell mRNA stability...
November 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29118127/peripheral-blood-biomarkers-of-disease-outcome-in-a-monkey-model-of-rift-valley-fever-encephalitis
#4
Elizabeth R Wonderlich, Amy L Caroline, Cynthia M McMillen, Aaron W Walters, Douglas S Reed, Simon M Barratt-Boyes, Amy L Hartman
Rift Valley Fever (RVF) is an emerging arboviral disease of livestock and people. Although a mosquito-borne virus, humans are infected through contact with or inhalation of virus-laden particles from contaminated animal carcasses. Some individuals infected with RVF virus (RVFV) develop meningoencephalitis resulting in morbidity and mortality. Little is known about the pathogenic mechanisms that lead to neurologic sequelae, and thus animal models that represent human disease are needed. African green monkeys (AGM) exposed to aerosols containing RVFV develop a reproducibly lethal neurological disease that resembles human illness...
November 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29107145/overlapping-cd8-and-cd4-t-cell-epitopes-identification-for-the-progression-of-epitope-based-peptide-vaccine-from-nucleocapsid-and-glycoprotein-of-emerging-rift-valley-fever-virus-using-immunoinformatics-approach
#5
Utpal Kumar Adhikari, M Mizanur Rahman
Rift Valley fever virus (RVFV) is an emergent arthropod-borne zoonotic infectious viral pathogen which causes fatal diseases in the humans and ruminants. Currently, no effective and licensed vaccine is available for the prevention of RVFV infection in endemic as well as in non-endemic regions. So, an immunoinformatics-driven genome-wide screening approach was performed for the identification of overlapping CD8+ and CD4+ T-cell epitopes and also linear B-cell epitopes from the conserved sequences of the nucleocapsid (N) and glycoprotein (G) of RVFV...
October 30, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29097548/a-glycerophospholipid-specific-pocket-in-the-rvfv-class-ii-fusion-protein-drives-target-membrane-insertion
#6
P Guardado-Calvo, K Atkovska, S A Jeffers, N Grau, M Backovic, J Pérez-Vargas, S M de Boer, M A Tortorici, G Pehau-Arnaudet, J Lepault, P England, P J Rottier, B J Bosch, J S Hub, F A Rey
The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring...
November 3, 2017: Science
https://www.readbyqxmd.com/read/29084217/wolbachia-effects-on-rift-valley-fever-virus-infection-in-culex-tarsalis-mosquitoes
#7
Brittany L Dodson, Elizabeth S Andrews, Michael J Turell, Jason L Rasgon
Innovative tools are needed to alleviate the burden of mosquito-borne diseases, and strategies that target the pathogen are being considered. A possible tactic is the use of Wolbachia, a maternally inherited, endosymbiotic bacterium that can (but does not always) suppress diverse pathogens when introduced to naive mosquito species. We investigated effects of somatic Wolbachia (strain wAlbB) infection on Rift Valley fever virus (RVFV) in Culex tarsalis mosquitoes. When compared to Wolbachia-uninfected mosquitoes, there was no significant effect of Wolbachia infection on RVFV infection, dissemination, or transmission frequencies, nor on viral body or saliva titers...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29063574/public-health-and-epidemiology-informatics
#8
R Thiébaut, F Thiessard
Objectives: To summarize current research in the field of Public Health and Epidemiology Informatics. Methods: The complete 2016 literature concerning public health and epidemiology informatics has been searched in PubMed and Web of Science, and the returned references were reviewed by the two section editors to select 14 candidate best papers. These papers were then peer-reviewed by external reviewers to allow the editorial team an enlightened selection of the best papers. Results: Among the 829 references retrieved from PubMed and Web of Science, three were finally selected as best papers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063573/best-paper-selection
#9
(no author information available yet)
Kite J, Foley BC, Grunseit AC, Freeman B. Please Like Me: Facebook and Public Health Communication. PLoS One 2016;11(9) http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162765 Sharpe JD, Hopkins RS, Cook RL, Striley CW. Evaluating Google, Twitter, and Wikipedia as Tools for Influenza Surveillance Using Bayesian Change Point Analysis: A Comparative Analysis. JMIR Public Health Surveill 2016 20;2(2) http://publichealth.jmir.org/2016/2/e161/ Tran A, Trevennec C, Lutwama J, Sserugga J, Gély M, Pittiglio C, Pinto J, Chevalier V...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29062192/hydrophilic-nanosilica-as-a-new-larvicidal-and-molluscicidal-agent-for-controlling-of-major-infectious-diseases-in-egypt
#10
Marwa M Attia, Soliman M Soliman, Mahmoud A Khalf
AIM: This research was conducted to evaluate the molluscicidal and mosquitocidal efficacy of silica nanoparticles in the eradication of the larvae and pupa of malaria and filariasis vector as well as vectors of rift-valley fever virus (Culex pipiens); Schistosoma mansoni vector and Biomphlaria alexandrina (snail and egg masses). MATERIALS AND METHODS: Hydrophilic nanosilica particles (NSPs) were characterized using transmission electron microscope during the preliminary part of the study; the stages were exposed to upgrade concentrations of NSP from 50 to 1200 ppm each for 24-36 h exposure time...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29061350/attenuation-and-protective-efficacy-of-rift-valley-fever-phlebovirus-rmp12-gm50-strain
#11
Hoai J Ly, Shoko Nishiyama, Nandadeva Lokugamage, Jennifer K Smith, Lihong Zhang, David Perez, Terry L Juelich, Alexander N Freiberg, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula that affects sheep, cattle, goats, camels, and humans. Effective vaccination of susceptible ruminants is important for the prevention of RVF outbreaks. Live-attenuated RVF vaccines are in general highly immunogenic in ruminants, whereas residual virulence might be a concern for vulnerable populations. It is also important for live-attenuated strains to encode unique genetic markers for the differentiation from wild-type RVFV strains...
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#12
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28985319/rift-valley-fever-does-wildlife-play-a-role
#13
Melinda K Rostal, Janice E Liang, David Zimmermann, Roy Bengis, Janusz Paweska, William B Karesh
Rift Valley fever (RVF) virus (RVFV) is an emerging vector-borne pathogen that causes sporadic epizootics and epidemics with multi-year, apparently quiescent, inter-epidemic periods. The epidemiology and ecology of the virus during these inter-epidemic periods is poorly understood. There is evidence for low-level circulation of the virus in livestock and wild ruminants; however, as of yet there is no evidence to identify a specific mammalian reservoir host. Using a systematic approach, this review synthesizes results from serosurveys, attempts at viral detection, and experimental infection of wildlife...
August 31, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28926632/risk-analysis-of-inter-species-reassortment-through-a-rift-valley-fever-phlebovirus-mp-12-vaccine-strain
#14
Hoai J Ly, Nandadeva Lokugamage, Shoko Nishiyama, Tetsuro Ikegami
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF outbreaks in ruminants and humans in endemic countries, and effective vaccination of animals and humans may minimize the impact of this disease...
2017: PloS One
https://www.readbyqxmd.com/read/28925970/current-status-of-rift-valley-fever-vaccine-development
#15
REVIEW
Bonto Faburay, Angelle Desiree LaBeaud, D Scott McVey, William C Wilson, Juergen A Richt
Rift Valley Fever (RVF) is a mosquito-borne zoonotic disease that presents a substantial threat to human and public health. It is caused by Rift Valley fever phlebovirus (RVFV), which belongs to the genus Phlebovirus and the family Phenuiviridae within the order Bunyavirales. The wide distribution of competent vectors in non-endemic areas coupled with global climate change poses a significant threat of the transboundary spread of RVFV. In the last decade, an improved understanding of the molecular biology of RVFV has facilitated significant progress in the development of novel vaccines, including DIVA (differentiating infected from vaccinated animals) vaccines...
September 19, 2017: Vaccines
https://www.readbyqxmd.com/read/28918558/colorimetric-detection-of-unamplified-rift-valley-fever-virus-genetic-material-using-unmodified-gold-nanoparticles
#16
Mostafa R Zaher, Hanaa A Ahmed, Kareem E Z Hamada, Reham H Tammam
Rift Valley fever virus (RVFV) is considered an enzootic virus in Africa. RVFV has caused several outbreaks in Egypt, sub-Saharan Africa and the Arabian Peninsula and is responsible for high mortality in ruminants and haemorrhagic fever in severe human cases. Although there are several molecular and serological diagnostic techniques used to detect this arthropod-borne virus with high sensitivity and efficiency, there is a need for a fast and reliable field screening test for rapid outbreak recording and containment...
September 16, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28915104/rift-valley-fever-phlebovirus-nss-protein-core-domain-structure-suggests-molecular-basis-for-nuclear-filaments
#17
Michal Barski, Benjamin Brennan, Ona K Miller, Jane A Potter, Swetha Vijayakrishnan, David Bhella, James H Naismith, Richard M Elliott, Ulrich Schwarz-Linek
Rift Valley fever phlebovirus (RVFV) is a clinically and economically important pathogen increasingly likely to cause widespread epidemics. RVFV virulence depends on the interferon antagonist non-structural protein (NSs), which remains poorly characterized. We identified a stable core domain of RVFV NSs (residues 83-248), and solved its crystal structure, a novel all-helical fold organized into highly ordered fibrils. A hallmark of RVFV pathology is NSs filament formation in infected cell nuclei. Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting it contains all essential determinants for nuclear translocation and filament formation...
September 15, 2017: ELife
https://www.readbyqxmd.com/read/28867393/reprint-of-epidemiology-of-brucellosis-q-fever-and-rift-valley-fever-at-the-human-and-livestock-interface-in-northern-c%C3%A3-te-d-ivoire
#18
Youssouf B Kanouté, Biégo G Gragnon, Christian Schindler, Bassirou Bonfoh, Esther Schelling
Northern Côte d'Ivoire is the main livestock breeding zone and has the highest livestock cross-border movements in Côte d'Ivoire. The aim of this study was to provide updated epidemiological data on three neglected zoonotic diseases, namely brucellosis, Q Fever and Rift Valley Fever (RVF). We conducted three-stage cross-sectional cluster surveys in livestock and humans between 2012 and 2014 in a random selection of 63 villages and a sample of 633 cattle, 622 small ruminants and 88 people. We administered questionnaires to capture risk factors and performed serological tests including the Rose Bengal Plate Test (RBPT), Brucella spp...
September 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28861841/the-first-serological-evidence-for-rift-valley-fever-infection-in-the-camel-goitered-gazelle-and-anatolian-water-buffaloes-in-turkey
#19
Sibel Gür, Mehmet Kale, Nural Erol, Orhan Yapici, Nuri Mamak, Sibel Yavru
Rift valley fever (RVF), a vector-borne zoonotic disease, is caused by a phlebovirus (family Bunyaviridae). The virus was initially characterized approximately 80 years ago in Kenya and disseminated to many countries in the continental Africa, Saudi Arabia, and Yemen. The infection has not been reported in Turkey. In this study, blood serum samples collected from camel (Camelus dromedairus), goitered gazelle (Gazella subgutturosa subgutturosa), and buffaloes (Bubalus bubalis linneaus) from 2000 to 2006 were investigated for RVF using C-ELISA...
October 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28854793/nss-protein-of-severe-fever-with-thrombocytopenia-syndrome-virus-suppresses-interferon-production-through-different-mechanism-than-rift-valley-fever-virus
#20
S Zhang, B Zheng, T Wang, A Li, J Wan, J Qu, C H Li, D Li, M Liang
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified Phlebovirus that causes severe fever with thrombocytopenia syndrome. Our study demonstrated that SFTSV NSs functioned as IFN antagonist mainly by suppressing TBK1/IKKε-IRF3 signaling pathway. NSs interacted with and relocalized TANK-binding kinase 1 (TBK1) into NSs-induced cytoplasmic structures and this interaction could effectively inhibit downstream phosphorylation and dimerization of interferon regulatory factor 3 (IRF3), resulting in the suppression of antiviral signaling and IFN induction...
2017: Acta Virologica
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