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Allergy rhinitis

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https://www.readbyqxmd.com/read/28544909/can-human-allergy-drug-fexofenadine-an-antagonist-of-histamine-h1-receptor-be-used-to-treat-dog-and-cat-homology-modeling-docking-and-molecular-dynamic-simulation-of-three-h1-receptors-in-complex-with-fexofenadine
#1
Safaa Sader, Jun Cai, Anna C G Muller, Chun Wu
Fexofenadine, a potent antagonist to human histamine 1 (H1) receptor, is a non-sedative third generation antihistamine that is widely used to treat various human allergic conditions such as allergic rhinitis, conjunctivitis and atopic dermatitis. Encouragingly, it's been successfully used to treat canine atopic dermatitis, this supports the notion that it might have a great potential for treating other canine allergic conditions and other mammal pets such as dog. Regrettably, while there is a myriad of studies conducted on the interactions of antihistamines with human H1 receptor, the similar studies on non-human pet H1 are considerably scarce...
May 17, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28543634/thaumatin-and-gum-arabic-allergy-in-chewing-gum-factory-workers
#2
Mattias P Tschannen, Ulrich Glück, Andreas J Bircher, Ingmar Heijnen, Claudia Pletscher
Thaumatin is a sweetener and flavor modifier commonly used in the food industry. Likewise, gum arabic is widely used as a food stabilizer and thickening agent. We report here that a powder mixture composed of 10% thaumatin and 90% gum arabic led to allergic symptoms in the upper airways in occupationally exposed individuals: four of eight workers of a chewing gum factory exposed to this powder mixture had pronounced rhinitis. A positive skin prick test result for pure thaumatin was obtained in all four individuals with rhinitis of whom two also had a positive skin prick test result for pure gum arabic and gum arabic-specific IgE...
May 24, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28542713/withdrawn-infant-formulas-containing-hydrolysed-protein-for-prevention-of-allergic-disease-and-food-allergy
#3
REVIEW
David A Osborn, John Kh Sinn, Lisa J Jones
BACKGROUND: Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants. OBJECTIVES: To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human breast milk. If hydrolysed formulas are effective, to determine what type of hydrolysed formula is most effective, including extensively or partially hydrolysed formula (EHF/PHF)...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28533901/allergic-respiratory-disease-ard-setting-forth-the-basics-proposals-of-an-expert-consensus-report
#4
Ana M Navarro, Julio Delgado, Rosa M Muñoz-Cano, M Teresa Dordal, Antonio Valero, Santiago Quirce
BACKGROUND: The variability of symptoms observed in patients with respiratory allergy often hampers classification based on the criteria proposed in guidelines on rhinitis and asthma. OBJECTIVES: We assessed specific aspects of allergic respiratory disease (ARD) that are not explicitly addressed in the guidelines in order to issue specific recommendations and thus optimize clinical practice. METHODS: Using the Delphi technique, 40 Spanish allergists were surveyed to reach consensus on 71 items related to ARD...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28532268/allergen-immunotherapy-in-allergic-rhinitis-current-use-and-future-trends
#5
Ludger Klimek, Oliver Pfaar, Jean Bousquet, Gabriela Senti, Thomas Kündig
Type-1 allergies are among the most chronic common diseases of humans. Allergen immunotherapy (AIT) is the only causative and disease-modifying treatment option besides allergen avoidance. Severe systemic adverse allergic reactions may be induced by every AIT treatment. Different approaches have been used to provide safer AIT preparations to lower or even totally overcome this risk. Areas covered: A structured literature recherche in Medline and Pubmed under inclusion of national and international guidelines and Cochrane meta-analyses has been performed aiming at reviewing clinical use of such approaches in AIT...
May 23, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#6
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28526624/guideline-recommendations-on-the-use-of-allergen-immunotherapy-in-house-dust-mite-allergy-time-for-a-change
#7
Moisés A Calderón, Jean Bousquet, G Walter Canonica, Lars-Olaf Cardell, Dolores Hernandez Fernandez de Rojas, Jörg Kleine-Tebbe, Pascal Demoly
Guidelines on the treatment of asthma, allergic rhinitis (AR) and allergen immunotherapy (AIT) lack recommendations for house dust mite (HDM) allergy. An expert panel reviewed current guidelines in the light of new data, to assess whether guidelines could be improved. Most guidelines and key position papers did not provide specific recommendations on treatment of allergic asthma (AA) caused by HDM allergy, although some included AIT as a treatment option for AA in general. Around half of the guidelines stated that AIT with HDM extract was an effective treatment for AR, with several indicating sublingual immunotherapy (SLIT) as an option...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28525399/allergen-immunotherapy-for-the-treatment-of-respiratory-allergies-in-the-elderly
#8
Gyu-Young Hur, Ji-Ho Lee, Hae-Sim Park
PURPOSE OF REVIEW: Respiratory allergies, including asthma and allergic rhinitis can also occur in the elderly. Allergen immunotherapy for allergic diseases is the only disease-modifying treatment for patients with allergies available thus far. Here, we review current evidence supporting the use of allergen immunotherapy in the elderly and discuss its efficacy and utility for the treatment of respiratory allergic diseases in this setting. RECENT FINDINGS: Subcutaneous and/or sublingual immunotherapy are effective therapeutic options in not only young but also older patients...
May 17, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28521324/the-role-of-hydrolyzed-formula-in-allergy-prevention
#9
Michael D Cabana
Asthma, eczema, food allergy, and allergic rhinitis are some of the most common pediatric, chronic conditions in the world. Breastfeeding is the optimal way to feed all infants. For those infants who are exposed to infant formula, some studies suggest that certain partially hydrolyzed or extensively hydrolyzed formulas may decrease the risk of allergic disease compared to nonhydrolyzed formulas for children with a family history of atopic disease. Overall, there is some evidence to suggest that partially hydrolyzed whey formulas and extensively hydrolyzed casein formulas may decrease the risk of developing eczema for infants at high risk of allergic disease...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28518538/how-does-the-pattern-of-aeroallergen-sensitization-change-over-time-across-all-ages
#10
Ji-Hyeon Shin, Dong-Hee Lee
BACKGROUND: Identification of aeroallergen sensitization is important for diagnosis and management of allergic diseases. Immunoglobulin E (IgE) sensitization status is known to change over time. However, few studies have explored changes in sensitization patterns across all age groups. The aim of the present study was to evaluate the changing patterns of in vitro IgE sensitization tests in allergic rhinitis patients across all age groups. METHODS: We recruited all patients who were diagnosed as having rhinitis and who underwent in vitro IgE sensitization testing from 2007 to 2016...
May 18, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28514997/the-prevalence-of-food-allergy-and-other-allergic-diseases-in-early-childhood-in-a-population-based-study-healthnuts-age-4-year-follow-up
#11
Rachel L Peters, Jennifer J Koplin, Lyle C Gurrin, Shyamali C Dharmage, Melissa Wake, Anne-Louise Ponsonby, Mimi L K Tang, Adrian J Lowe, Melanie Matheson, Terence Dwyer, Katrina J Allen
BACKGROUND: The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse. OBJECTIVE: This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years...
April 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28501885/euforea-rhinology-research-forum-2016-report-of-the-brainstorming-sessions-on-needs-and-priorities-in-rhinitis-and-rhinosinusitis
#12
P W Hellings, C A Akdis, C Bachert, J Bousquet, B Pugin, G Adriaensen, R Advani, I Agache, C Anjo, R Anmolsingh, E Annoni, T Bieber, A Bizaki, I Braverman, I Callebaut, J A Castillo Vizuete, T Chalermwatanachai, R Chmielewski, C Cingi, L Cools, C Coppije, M E Cornet, I De Boeck, E De Corso, G De Greve, M Doulaptsi, R Edmiston, S Erskine, E Gevaert, P Gevaert, K Golebski, C Hopkins, V Hox, C Jaeggi, G Joos, S Khwaja, A Kjeldsen, L Klimek, M Koennecke, I Kortekaas Krohn, O Krysko, B N Kumar, C Langdon, B Lange, G Lekakis, P Levie, E Lourijsen, V J Lund, K Martens, R Mösges, J Mullol, T D Nyembue, S Palkonen, C Philpott, J Pimentel, A Poirrier, A C Pratas, E Prokopakis, L Pujols, P Rombaux, C Schmidt-Weber, C Segboer, I Spacova, J Staikuniene, B Steelant, E A Steinsvik, A Teufelberger, L Van Gerven, K Van Gool, R Verbrugge, B Verhaeghe, P Virkkula, S Vlaminck, E Vries-Uss, M Wagenmann, T Zuberbier, S F Seys, W J Fokkens
The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care pathways and research needs in rhinitis and rhinosinusitis...
May 14, 2017: Rhinology
https://www.readbyqxmd.com/read/28501765/enhanced-sublingual-immunotherapy-by-tat-fused-recombinant-allergen-in-a-murine-rhinitis-model
#13
Farhad Salari, Fatemeh Vahedi, Abdol-Reza Varasteh, Hanieh Ketabdar, Jamshidkhan Chamani, Mojtaba Sankian
Allergen-specific sublingual immunotherapy (SLIT) is well known as an effective and non-invasive route to induce allergy desensitization. The goal of this study was to investigate whether a TAT-fused recombinant allergen could enhance SLIT efficacy. BALB/c mice sensitized to the main allergen (Che a 3) of Chenopodium album pollen were treated sublingually either with rChe a 3 (100μg/dose) or rTAT-Che a 3 (100μg/dose), two times per week for eight weeks. SLIT with rTAT-Che a 3 led to significantly greater allergen-specific IgG2a than rChe a 3; however, neither rTAT-Che a 3 nor rChe a 3 affected allergen-specific IgE or IgG1 antibody levels...
May 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28497673/body-mass-index-and-skin-reactivity-to-histamine-and-dermatophagoides-pteronyssinus-in-children-and-adolescents-followed-in-a-pediatric-allergy-service
#14
A Keller Franco, R Oselka Sarni, M Carvalho Mallozi, D Solé
Rationale. Recent data suggest that the nutritional status assessed by body mass index (BMI) is positively associated with skin reactivity to histamine in children. Objective. To study the relation between BMI and skin reactivity to histamine and Dermatophagoides pteronyssinus in allergic children and adolescents. Methods. The medical charts of patients attended in our outpatient clinic between 2013 and 2014 (n = 972) were evaluated. Only patients with asthma, allergic rhinitis or wheezing infants sensitized to at least one aeroallergen were selected: a total of 626 patients (6 months to 19 year-olds; 60...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28493047/effects-of-cpap-in-patients-with-obstructive-apnoea-is-the-presence-of-allergic-rhinitis-relevant
#15
A Cisternas, F Aguilar, J M Montserrat, M Àvila, M Torres, A Iranzo, J Berenguer, I Vilaseca
PURPOSE: The aim of the study is to compare the effects of continuous positive airway pressure (CPAP) on the nasal cavities of patients with obstructive sleep apnoea (OSA) and with or without allergic rhinitis (AR/nonAR). METHODS: This paper is a prospective, longitudinal study. Thirty-four consecutive CPAP treatment-adherent patients with OSA (17 AR and 17 nonAR) were evaluated before and 2 months after treatment, by means of clinical (otorhinolaryngological symptoms, daytime sleepiness, overall and rhinoconjunctivitis-specific quality of life), anatomical (otorhinolaryngological examination), functional (auditory function, tubal function, nasal airflow, and mucociliary clearance), and biological variables (nasal cytology)...
May 10, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28490399/specific-immunoglobulin-e-and-immunoglobulin-g4-toward-major-allergens-of-house-dust-mite-during-allergen-specific-immunotherapy
#16
Jianjun Chen, Yue Zhou, Yanjun Wang, Yiwu Zheng, Xuxin Lai, Emma Westermann-Clark, Seong H Cho, Weijia Kong
BACKGROUND: Specific immunoglobulin E (sIgE) and sIgG4 to house-dust mite (HDM) major allergens during allergen immunotherapy (AIT) and their clinical relevance remain unclear. OBJECTIVE: To investigate the variation of sIgE and sIgG4 to HDM major allergens and the correlation with clinical responses during AIT in patients with allergic rhinitis. METHODS: Thirty-nine patients with HDM allergy were divided into the AIT group (taking immunotherapy) and the control group (medication only use)...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28487842/dietary-primary-prevention-of-allergic-diseases-in-children-the-philippine-guidelines
#17
REVIEW
Marysia Stella T Recto, Maria Lourdes G Genuino, Mary Anne R Castor, Roxanne J Casis-Hao, Diana R Tamondong-Lachica, Maria Imelda V Sales, Marilou G Tan, Karen S Mondonedo, Regina C Dionisio-Capulong
Allergic diseases, such as asthma, allergic rhinitis, eczema, and food allergy, are preventable diseases. Primary prevention strategies of allergic diseases have been in scrutiny. Effective prevention strategies maybe started prenatally, postnatally, during infancy, and even during childhood. These guidelines have been prepared by the Philippine Society of Allergy, Asthma and Immunology and the Philippine Society for Pediatric Gastroenterology, Hepatology and Nutrition. They aim to provide evidence-based recommendations for the dietary primary prevention of allergic diseases in children...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28487836/allergic-conjunctivitis-in-asia
#18
REVIEW
Bernard Yu-Hor Thong
Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%-70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally milder than the more chronic and persistent atopic and vernal keratoconjunctivitis. Natural allergens like house dust mites (HDM), temperate and subtropical grass and tree pollen are important triggers that drive allergic inflammation in AC in the Asia-Pacific region. Climate change, environmental tobacco smoke, pollutants derived from fuel combustion, Asian dust storms originating from central/north Asia and phthalates may also exacerbate AR/C...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28484688/what-are-the-effects-of-a-mediterranean-diet-on-allergies-and-asthma-in-children
#19
REVIEW
Jose A Castro-Rodriguez, Luis Garcia-Marcos
This review updates the relationship between the adherence to Mediterranean diet (MedDiet) assessed by questionnaire and asthma, allergic rhinitis, or atopic eczema in childhood. It deals with the effect of MedDiet in children on asthma/wheeze, allergic rhinitis, and atopic dermatitis/eczema, and also with the effect of MedDiet consumption by the mother during pregnancy on the inception of asthma/wheeze and allergic diseases in the offspring. Adherence to MedDiet by children themselves seems to have a protective effect on asthma/wheezing symptoms after adjustment for confounders, although the effect is doubtful on lung function and bronchial hyperresponsiveness...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28483565/when-is-allergen-immunotherapy-effective
#20
Akane Hara, Yoh Iwasa
Allergen immunotherapy is used to treat allergic symptoms such as rhinitis and itchy eyes in Japanese patients with cedar pollen allergy (JCPA). Administration of small amounts of pollen over several years may suppress severe allergic symptoms when these patients are later exposed to large amounts of pollen in the environment. Herein, we developed a simple mathematical model to identify conditions in which allergen immunotherapy is effective. We considered the dynamics of type 2 T helper cells (Th2) and regulatory T cells (Treg), both of which differentiate from naive T cells...
May 5, 2017: Journal of Theoretical Biology
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