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https://www.readbyqxmd.com/read/29146584/microrna-tissue-atlas-of-the-malaria-mosquito-anopheles-gambiae
#1
Lena Lampe, Elena A Levashina
Anopheles gambiae mosquitoes transmit the human malaria parasite Plasmodium falciparum, which causes the majority of fatal malaria cases worldwide. The hematophagous life style defines the mosquito reproductive biology and is exploited by P. falciparum for its own sexual reproduction and transmission. The two main phases of the mosquito reproductive cycle, pre-vitellogenic (PV) and post-blood meal (PBM) shape its capacity to transmit malaria. Transition between these phases is tightly coordinated to ensure homeostasis between mosquito tissues and successful reproduction...
November 16, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29131369/photobiomodulation-for-traumatic-brain-injury-and-stroke
#2
REVIEW
Michael R Hamblin
There is a notable lack of therapeutic alternatives for what is fast becoming a global epidemic of traumatic brain injury (TBI). Photobiomodulation (PBM) employs red or near-infrared (NIR) light (600-1100nm) to stimulate healing, protect tissue from dying, increase mitochondrial function, improve blood flow, and tissue oxygenation. PBM can also act to reduce swelling, increase antioxidants, decrease inflammation, protect against apoptosis, and modulate microglial activation state. All these mechanisms of action strongly suggest that PBM delivered to the head should be beneficial in cases of both acute and chronic TBI...
November 13, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29124437/optimal-vitamin-d-intake-for-preventing-serum-25-hydroxyvitamin-d-insufficiency-in-young-japanese-women
#3
Hiroaki Ohta, Tatsuhiko Kuroda, Naoko Tsugawa, Yoshiko Onoe, Toshio Okano, Masataka Shiraki
Populations of East Asian countries have been known to have low calcium intakes and low serum 25(OH)D concentrations, suggesting that Ca and vitamin D (VitD)-deficiencies are commonly observed. These nutritional imbalances may lead to low peak bone mass (PBM). The low PBM seen in Ca/VitD-deficient individuals may lead to osteoporosis, as well as an increased risk of fracture. A survey was conducted in young Japanese women (n = 296, 21.2 ± 2.3 years old) on their Ca/VitD intakes and serum 25(OH)D levels, which demonstrated a significant positive correlation between VitD intake and serum 25(OH)D levels (R (2) = 0...
November 9, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29121593/stimulation-of-liver-igf-1-expression-promotes-peak-bone-mass-achievement-in-growing-rats-a-study-with-pomegranate-seed-oil
#4
Deepa Bachagol, Gilbert Stanley Joseph, Govindraj Ellur, Kalpana Patel, Pamisetty Aruna, Monika Mittal, Shyamsundar Pal China, Ravendra Pratap Singh, Kunal Sharan
Peak bone mass (PBM) achieved at adulthood is a strong determinant of future onset of osteoporosis, and maximizing it is one of the strategies to combat the disease. Recently, pomegranate seed oil (PSO) has been shown to have bone-sparing effect in ovariectomized mice. However, its effect on growing skeleton and its molecular mechanism remain unclear. In the present study, we evaluated the effect of PSO on PBM in growing rats and associated mechanism of action. PSO was given at various doses to 21-day-old growing rats for 90 days by oral gavage...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29113099/a-blood-meal-enhances-innexin-mrna-expression-in-the-midgut-malpighian-tubules-and-ovaries-of-the-yellow-fever-mosquito-aedes-aegypti
#5
Travis L Calkins, Peter M Piermarini
Mosquitoes are vectors of pathogens that cause diseases of medical and veterinary importance. Female mosquitoes transmit these pathogens while taking a blood meal, which most species require to produce eggs. The period after a blood meal is a time of extreme physiological change that requires rapid coordination of specific tissues. Gap junctions (GJ) are intercellular channels that aid in the coordination of cells within tissues via the direct transfer of certain small molecules and ions between cells. Evolutionarily distinct groups of proteins form the gap junctions of vertebrate and invertebrate animals (connexins and innexins, respectively)...
November 6, 2017: Insects
https://www.readbyqxmd.com/read/29107824/antimicrobial-photodynamic-therapy-apdt-and-photobiomodulation-pbm-660nm-in-a-dog-with-chronic-gingivostomatitis
#6
Paula Abreu Villela, Naiá de Carvalho de Souza, Juliana Durigan Baia, Marco Antonio Gioso, Ana Cecília Corrêa Aranha, Patrícia Moreira de Freitas
Chronic gingivostomatitis in dogs is an inflammatory syndrome of the oral cavity, which treatment and control of concomitant periodontitis allow healing in most of the cases. In the presence of recurrent lesions, invasive methods are necessary to treat lesions and pain. As a conservative adjuvant method, photobiomodulation (PBM) with low power laser is able to promote reduction of tissue pain and tissue inflammation besides increasing vascularization and healing, restoring the normal function of the irradiated organ in a shorter time...
October 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29099397/implementation-of-a-blood-management-program-at-a-tertiary-care-hospital-effect-on-transfusion-practices-and-clinical-outcomes-among-patients-undergoing-surgery
#7
Faiz Gani, Marcelo Cerullo, Aslam Ejaz, Pranjal B Gupta, Vincent M Demario, Fabian M Johnston, Steven M Frank, Timothy M Pawlik
BACKGROUND: Patient blood management (PBM) programs represent a perioperative bundle of care that aim to reduce or eliminate unnecessary transfusions. OBJECTIVE: To evaluate the impact of a PBM program on transfusion practices and clinical outcomes at a single surgical department at a tertiary care hospital in the United States. METHODS: This pre-post, cross-sectional study was performed using data from 17,114 patients undergoing gastrointestinal surgery between 2010 and 2013...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29098452/synchronous-primary-gallbladder-and-pancreatic-cancer-associated-with-congenital-biliary-dilatation-and-pancreaticobiliary-maljunction
#8
Haruki Mori, Hiroya Iida, Hiromitsu Maehira, Naomi Kitamura, Tomoharu Shimizu, Masaji Tani
INTRODUCTION: Synchronous double cancer of the gallbladder and pancreas that is associated with congenital biliary dilatation (CBD) and pancreaticobiliary maljunction (PBM) is extremely rare. PBM is frequently reported in Asia, particularly in Japan. We report a surgical case of synchronous double cancer in a patient with primary gallbladder and pancreatic cancer. PRESENTATION OF CASE: A 72-year-old woman with epigastralgia underwent subtotal stomach-preserving pancreaticoduodenectomy and gallbladder bed resection for synchronous primary gallbladder and pancreatic head cancer...
November 2, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29096619/incorporating-18-fdg-pet-defined-pelvic-active-bone-marrow-in-the-automatic-treatment-planning-process-of-anal-cancer-patients-undergoing-chemo-radiation
#9
Pierfrancesco Franco, Christian Fiandra, Francesca Arcadipane, Elisabetta Trino, Francesca Romana Giglioli, Riccardo Ragona, Umberto Ricardi
BACKGROUND: To investigate whether the incorporation of (18)FDG-PET into the automatic treatment planning process may be able to decrease the dose to active bone marrow (BM) for locally advanced anal cancer patients undergoing concurrent chemo-radiation (CHT-RT). METHODS: Ten patients with locally advanced anal cancer were selected. Bone marrow within the pelvis was outlined as the whole outer contour of pelvic bones or employing (18)FDG-PET to identify active BM within osseous structures...
November 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29082529/patient-blood-management-knowledge-and-practice-among-clinicians-from-seven-european-university-hospitals-a%C3%A2-multicentre-survey
#10
P M Manzini, A M Dall'Omo, S D'Antico, A Valfrè, K Pendry, A Wikman, D Fischer, D Borg-Aquilina, S Laspina, E C M van Pampus, M van Kraaij, M T Bruun, J Georgsen, J Grant-Casey, P S Babra, M F Murphy, G Folléa, K Aranko
BACKGROUND AND OBJECTIVES: The aim of this survey was to evaluate the knowledge about Patient Blood Management (PBM) principles and practices amongst clinicians working in seven European hospitals participating in a European Blood Alliance (EBA) project. MATERIALS AND METHODS: A web-based questionnaire was sent to 4952 clinicians working in medical, surgery and anaesthesiology disciplines. The responses were analysed, and the overall results as well as a comparison between hospitals are presented...
October 29, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29076030/the-absolute-volume-of-pet-defined-active-bone-marrow-spared-predicts-for-high-grade-hematologic-toxicity-in-cervical-cancer-patients-undergoing-chemoradiation
#11
Y M Zhou, C Freese, T Meier, D Go, K Khullar, M Sudhoff, M Lamba, J Kharofa
INTRODUCTION: Hematologic toxicity (HT) in cervical cancer patients can cause treatment delays and reduction in chemotherapy, especially in high risk patients. Dose to PET-defined regions of active bone marrow (ABM) has been shown to correlate with cytopenias. An absolute volume of ABM spared may accurately represent hematopoietic reserve and risk of HT. This analysis evaluates whether the volume of ABM spared can more accurately predict HT compared to conventional dosimetric parameters...
October 26, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29072898/the-epstein-barr-virus-b-zip-protein-zta-recognizes-specific-dna-sequences-containing-5-methylcytosine-and-5-hydroxymethylcytosine
#12
Desiree Tillo, Sreejana Ray, Khund-Sayeed Syed, Mary Rose Gaylor, Ximiao He, Jun Wang, Nima Assad, Stewart R Durell, Aleksey Porollo, Matthew T Weirauch, Charles Vinson
The Epstein-Barr virus (EBV) B-ZIP transcription factor Zta binds to many DNA sequences containing methylated CG dinucleotides. Using protein binding microarrays (PBMs), we analyzed the sequence specific DNA binding of Zta to four kinds of double-stranded DNA (dsDNA): (1) DNA containing cytosine in both strands, (2) DNA with 5-methylcytosine (5mC) in one strand and cytosine in the second strand, (3) DNA with 5-hydroxymethylcytosine (5hmC) in one strand and cytosine in the second strand, and (4) DNA in which both cytosines in all CG dinucleotides contain 5mC...
November 10, 2017: Biochemistry
https://www.readbyqxmd.com/read/29068296/time-to-lift-the-curtain-on-pbm-wheeling-and-dealing
#13
Robert Calandra
PBMs say their deals need to be kept private so they can drive a hard bargain with manufacturers. But employers, consumer groups, and legislators are calling for more PBM transparency. There's bipartisan support for legislation that would force more openness.
October 2017: Managed Care
https://www.readbyqxmd.com/read/29064875/perioperative-patient-blood-management-to-improve-outcomes
#14
Neel Desai, Nick Schofield, Toby Richards
Anemia is common in elective surgery and is an independent risk factor for morbidity and mortality. Historical management of anemia has focused on the use of allogeneic blood transfusion but this in itself is not without risk. It too has been independently associated with morbidity and mortality, let alone the costs and relative shortage of this resource. In recognition of this, patient blood management (PBM) shifts the focus from the product to the patient and views the patient's own blood as a resource that should be conserved and managed appropriately as a standard of care...
October 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29056360/photobiomodulation-therapy-promotes-neurogenesis-by-improving-post-stroke-local-microenvironment-and-stimulating-neuroprogenitor-cells
#15
Luodan Yang, Donovan Tucker, Yan Dong, Chongyun Wu, Yujiao Lu, Yong Li, Juan Zhang, Timon Cheng-Yi Liu, Quanguang Zhang
Recent work has indicated that photobiomodulation (PBM) may beneficially alter the pathological status of several neurological disorders, although the mechanism currently remains unclear. The current study was designed to investigate the beneficial effect of PBM on behavioral deficits and neurogenesis in a photothrombotic (PT) model of ischemic stroke in rats. From day 1 to day 7 after the establishment of PT model, 2-minute daily PBM (CW, 808nm, 350mW/cm(2), total 294J at scalp level) was applied on the infarct injury area (1...
October 19, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29053051/photobiomodulation-therapy-alleviates-tissue-fibroses-associated-with-chronic-graft-versus-host-disease-two-case-reports-and-putative-anti-fibrotic-roles-of-tgf-%C3%AE
#16
Joel B Epstein, Judith E Raber-Durlacher, Marie-Charlotte Huysmans, Maria C E Schoordijk, Jerry E Cheng, Rene-Jean Bensadoun, Praveen R Arany
OBJECTIVE: Patients who receive allogeneic hematopoietic stem cell transplantation may experience oral complications due to chronic graft-versus-host disease (cGVHD). The manifestations may include progressive sclerosis-like changes that may involve various body sites, including the oropharynx. METHODS AND RESULTS: We present two cGVHD cases of oropharyngeal fibrotic changes that affected functions that were treated with photobiomodulation (PBM) therapy. These case reports suggest that PBM therapy represents an additional, innovative approach affecting discrete phases in cGVHD-associated fibrotic changes...
October 19, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29052164/the-role-of-condition-specific-preference-based-measures-in-health-technology-assessment
#17
REVIEW
Donna Rowen, John Brazier, Roberta Ara, Ismail Azzabi Zouraq
A condition-specific preference-based measure (CSPBM) is a measure of health-related quality of life (HRQOL) that is specific to a certain condition or disease and that can be used to obtain the quality adjustment weight of the quality-adjusted life-year (QALY) for use in economic models. This article provides an overview of the role and the development of CSPBMs, and presents a description of existing CSPBMs in the literature. The article also provides an overview of the psychometric properties of CSPBMs in comparison with generic preference-based measures (generic PBMs), and considers the advantages and disadvantages of CSPBMs in comparison with generic PBMs...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29052160/the-use-of-mapping-to-estimate-health-state-utility-values
#18
REVIEW
Roberta Ara, Donna Rowen, Clara Mukuria
Mapping functions are estimated using regression analyses and are frequently used to predict health state utility values (HSUVs) in decision analytic models. Mapping functions are used when evidence on the required preference-based measure (PBM) is not available, or where modelled values are required for a decision analytic model, for example to control for important sociodemographic variables (such as age or gender). This article provides an overview of the latest recommendations including pre-mapping considerations, the mapping process including data requirements for undertaking the estimation of mapping functions, regression models for estimating mapping functions, assessing performance and reporting standards for mapping studies...
October 19, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29037876/photobiomodulation-of-local-alterations-induced-by-bthtx-i-a-phospholipase-a2-myotoxin-from-bothrops-jararacussu-snake-venom-in-vivo-and-in-vitro-evaluation
#19
Adriano Silvio Dos Santos, Ludmila Guimarães-Sousa, Maricilia Silva Costa, Luis Fernando Zamuner, Norma Cristina Sousa, Stephen Hyslop, Andreimar M Soares, Maria Cristina Chavantes, José Carlos Cogo, Stella Regina Zamuner
This report describes the effect of photobiomodulation (PBM) on edema formation, leukocyte influx, prostaglandin E2 (PGE2) biosynthesis and cytotoxicity caused by bothropstoxin-I (BthTX-I), a phospholipase A2 (PLA2) homologue isolated from Bothrops jararacussu snake venom. Swiss mice or C2C12 cells were irradiated with low-level laser (LLL) at 685nm wavelength, an energy density of 4.6J/cm(2) and an irradiation time of 13s. To evaluate the effect on edema formation and leukocyte influx, LLL was applied to the site of inoculation 30min and 3h post-injection...
October 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29032938/the-jak-stat-signaling-pathway-and-photobiomodulation-in-chronic-wound-healing
#20
Sandy W Jere, Heidi Abrahamse, Nicolette N Houreld
Wound healing is a physiological process that occurs in overlapping phases namely hemostasis, inflammation, proliferation, and remodeling. Chronic wounds fail to proceed through these reparative processes to achieve the functional integrity within the expected time. Wound healing relies upon growth factors and cytokines for the precise and accurate regulation of cellular responses. These are achieved through the use of complex growth factor/cytokine induced signaling pathways. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway transmits extracellular signals to the nucleus for the transcription of genes involved in proliferation and differentiation, to name but a few...
October 6, 2017: Cytokine & Growth Factor Reviews
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