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https://www.readbyqxmd.com/read/28078845/effect-of-low-energy-light-irradiation-by-light-emitting-diode-on-u937-cells
#1
G Spoto, V De Iuliis, M Petrini, V Flati, J Di Gregorio, D Vitale, M Caruso, V Dadorante, M Ciarmoli, I Robuffo, S Martinotti, E Toniato
Photobiomodulation (PBM) can induce a set of different biological modulators either in vitro or in vivo. Experimental evidence has highlighted the role of light effects on the mechanisms related to inflammation, apoptosis and autophagy. The goal of this project was the evaluation of PBM on U937, an established cell line of histiocytic lymphoma origin. Several aspects of modulation of proinflammatory pathways were analyzed and autophagic and proapoptotic mechanisms related to low laser light exposure of cells were studied...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28072934/aetiology-of-preoperative-anaemia-in-patients-undergoing-elective-cardiac-surgery-the-challenge-of-pillar-one-of-patient-blood-management
#2
J Abraham, R Sinha, K Robinson, V Scotland, D Cardone
Preoperative anaemia is common in patients undergoing cardiac surgery. Whilst there is a strong association with increased morbidity and mortality, it is currently unclear whether treatment of anaemia leads to patient benefit. This retrospective study aimed to determine the aetiology of preoperative anaemia in a cohort of patients undergoing elective cardiac surgery over two years at a tertiary hospital. Laboratory data obtained at the preoperative assessment clinic visit were assessed to stratify patients into four groups-iron deficiency anaemia (IDA), possible IDA, anaemia of chronic disease (ACD) and non-anaemic patients with low ferritin according to the 'Preoperative haemoglobin assessment and optimisation template' of the Australian Patient Blood Management (PBM) Guidelines...
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28070154/proposed-mechanisms-of-photobiomodulation-or-low-level-light-therapy
#3
Lucas Freitas de Freitas, Michael R Hamblin
Photobiomodulation (PBM) also known as low-level laser (or light) therapy (LLLT), has been known for almost 50 years but still has not gained widespread acceptance, largely due to uncertainty about the molecular, cellular, and tissular mechanisms of action. However, in recent years, much knowledge has been gained in this area, which will be summarized in this review. One of the most important chromophores is cytochrome c oxidase (unit IV in the mitochondrial respiratory chain), which contains both heme and copper centers and absorbs light into the near-infra-red region...
May 2016: IEEE Journal of Selected Topics in Quantum Electronics
https://www.readbyqxmd.com/read/28061478/mitotic-control-of-human-papillomavirus-genome-containing-cells-is-regulated-by-the-function-of-the-pdz-binding-motif-of-the-e6-oncoprotein
#4
Elizabeth K Marsh, Craig P Delury, Nicholas J Davies, Christopher J Weston, Mohammed A L Miah, Lawrence Banks, Joanna L Parish, Martin R Higgs, Sally Roberts
The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types contributes to the development of HPV-associated malignancies. Here, using a primary human keratinocyte-based model of the high-risk HPV18 life cycle, we identify a novel link between the E6 PBM and mitotic stability. In cultures containing a mutant genome in which the E6 PBM was deleted there was an increase in the frequency of abnormal mitoses, including multinucleation, compared to cells harboring the wild type HPV18 genome...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28056208/the-effect-of-photobiomodulation-on-the-sea-urchin-paracentrotus-lividus-echinodermata-by-using-higher-fluence-on-fertilization-embryogenesis-and-larval-development-an-in-vitro-study
#5
Andrea Amaroli, Chiara Gambardella, Sara Ferrando, Reem Hanna, Alberico Benedicenti, Lorenzo Gallus, Marco Faimali, Stefano Benedicenti
OBJECTIVE: The aim of this study was to investigate the photobiomodulation (PBM) effect of the 808 nm diode laser irradiation on spermatozoa, eggs, fertilized eggs, embryos, and larvae of Paracentrotus lividus, using two different power settings. BACKGROUND DATA: Studies have shown the possible use of PBM in artificial insemination. These have shown the potential effect of low-power laser irradiation on spermatozoa, while there are few studies on the effect of laser photonic energy on oocytes and almost no reports on the influence of lasers in embryogenesis...
December 30, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28053920/influence-of-adolescents-physical-activity-on-bone-mineral-acquisition-a-systematic-review-article
#6
REVIEW
Mohamed S Zulfarina, Ahmad M Sharkawi, Zaris-Sm Aqilah-S N, Sabarul-Afian Mokhtar, Shuid A Nazrun, Isa Naina-Mohamed
BACKGROUND: This study conducted to examine and to provide a systematic literature over the influence of adolescents' physical activity (PA) in maximizing`s peak bone mass (PBM). PBM or the 'bone bank' is an important determinant in achieving healthy bone. PA is one of the bone's lifestyle contributors and high PBM is one of the major strategies for preventing osteoporosis. METHODS: A computerized literature search using Medline (Ovid) and Scopus were conducted to identify relevant observational studies on the influence of different level of PA on bone acquisition among the healthy adolescent population...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28047407/su-f-t-110-lkb-modeling-of-acute-hematologic-toxicity-in-rectal-cancer
#7
H Deng, K Cheng, X Wan
PURPOSE: To investigate dosimetric parameters correlated with acute hematologic toxicity (HT) in patients with rectal cancer treated with IMRT and concurrent chemotherapy. METHODS: We analyzed 127 rectal cancer patients receiving IMRT and concurrent chemotherapy. Whole pelvic bone marrow (PBM) was contoured for each patient including lumbosacral spine (LSSP), ilium and lower pelvic (LP). The equivalent uniform dose (EUD) of each region and the PBM were calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28002646/elevated-bile-amylase-level-without-pancreaticobiliary-maljunction-is-a-risk-factor-for-gallbladder-carcinoma
#8
Takaaki Fujimoto, Takao Ohtsuka, Yohei Nakashima, Yoshitaka Gotoh, Kenjiro Date, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yoshinao Oda, Masafumi Nakamura
BACKGROUND: Elevated bile amylase level in patients with pancreaticobiliary maljunction (PBM) or high confluence of pancreaticobiliary ducts (HCPBD) is well known as a risk factor for gallbladder carcinoma (GBC) development. However, the effects of occult pancreaticobiliary reflux (OPR), a condition characterized by high bile amylase level in the presence of an anatomically normal pancreaticobiliary junction, on GBC development remain unclear. The aim of this study was to assess the relationship between OPR and GBC...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28001759/transcranial-low-level-laser-light-therapy-for-brain-injury
#9
Connor Thunshelle, Michael R Hamblin
BACKGROUND: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). METHODS: We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27991540/bursty-properties-revealed-in-large-scale-brain-networks-with-a-point-based-method-for-dynamic-functional-connectivity
#10
William Hedley Thompson, Peter Fransson
The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point based method (PBM) presented here derives covariance matrices after clustering individual time points based upon their global spatial pattern. This method achieved increased temporal sensitivity, together with temporal network theory, allowed us to study functional integration between resting-state networks...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27989012/photobiomodulation-reduces-drusen-volume-and-improves-visual-acuity-and-contrast-sensitivity-in-dry-age-related-macular-degeneration
#11
Graham F Merry, Marion R Munk, Robert S Dotson, Michael G Walker, Robert G Devenyi
PURPOSE: To evaluate the efficacy of photobiomodulation (PBM) treatment for patients with dry age-related macular degeneration (AMD). METHODS: Assessments on 42 eyes with dry AMD (age related eye disease study (AREDS) 2-4) were conducted. Multiwavelength light emitting diode (LED) light comprising of yellow (590 nm), red (670 nm) and near-infrared (790 nm) bandwidths was applied to subjects' eyes for a treatment course of 3 weeks. Outcome measures were changes in best-corrected visual acuity (BCVA), contrast sensitivity (CS), drusen volume and central drusen thickness...
December 18, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27987219/relative-efficacy-of-tranexamic-acid-and-preoperative-anemia-treatment-for-reducing-transfusions-in-total-joint-arthroplasty
#12
Joseph F Styron, Alison K Klika, Caleb R Szubski, Deborah Tolich, Wael K Barsoum, Carlos A Higuera
BACKGROUND: This study aimed to evaluate the efficacy of a perioperative blood management (PBM) protocol at a large, tertiary hospital at reducing blood transfusions after total hip or knee arthroplasty (THA or TKA). STUDY DESIGN AND METHODS: A retrospective review of the PBM for patients undergoing THA or TKA was performed. Adjusted multiple logistic and Poisson regression models examined the effect of patient characteristics and preoperative, intraoperative, and postoperative factors on the likelihood of transfusion and units transfused...
December 17, 2016: Transfusion
https://www.readbyqxmd.com/read/27979445/highly-efficient-training-refinement-and-validation-of-a-knowledge-based-planning-quality-control-system-for-radiation-therapy-clinical-trials
#13
Nan Li, Ruben Carmona, Igor Sirak, Linda Kasaova, David Followill, Jeff Michalski, Walter Bosch, William Straube, Loren K Mell, Kevin L Moore
PURPOSE: To demonstrate an efficient method for training and validation of a knowledge-based planning (KBP) system as a radiation therapy clinical trial plan quality-control system. METHODS AND MATERIALS: We analyzed 86 patients with stage IB through IVA cervical cancer treated with intensity modulated radiation therapy at 2 institutions according to the standards of the INTERTECC (International Evaluation of Radiotherapy Technology Effectiveness in Cervical Cancer, National Clinical Trials Network identifier: 01554397) protocol...
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27960251/tropospheric-gom-at-the-pic-du-midi-observatory-correcting-bias-in-denuder-based-observations
#14
Nicolas Marusczak, Jeroen E Sonke, Xuewu Fu, Martin Jiskra
Gaseous elemental mercury (GEM, Hg) emissions are transformed to divalent reactive Hg (RM) forms throughout the troposphere and stratosphere. RM is often operationally quantified as the sum of particle bound Hg (PBM) and gaseous oxidized Hg (GOM). The measurement of GOM and PBM is challenging and under mounting criticism. Here we intercompare six months of automated GOM and PBM measurements using a Tekran (TK) KCl-coated denuder and quartz regenerable particulate filter method (GOMTK, PBMTK, and RMTK) with RMCEM collected on cation exchange membranes (CEMs) at the high altitude Pic du Midi Observatory...
December 27, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27919530/sources-of-formaldehyde-and-their-contributions-to-photochemical-o3-formation-at-an-urban-site-in-the-pearl-river-delta-southern-china
#15
Z H Ling, J Zhao, S J Fan, X M Wang
Two models (the Positive Matrix Factorization (PMF) model and a photochemical box model with Master Chemical Mechanism (PBM-MCM)) were applied to analyze the formaldehyde (HCHO) data collected in July 2006 at an urban site (GPEMC) in the Pearl River Delta (PRD), southern China. Three major HCHO sources (secondary formation, vehicular exhaust, and solvent usage) were identified and they were found to contribute in average 53%, 31% and 16% respectively to the total HCHO loading at GPEMC. Alkenes was the most important group contributing to the secondary formation of HCHO, followed by aromatics and alkanes...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27913969/laser-photobiomodulation-830-and-660%C3%A2-nm-in-mast-cells-vegf-fgf-and-cd34-of-the-musculocutaneous-flap-in-rats-submitted-to-nicotine
#16
Lais Mara Siqueira das Neves, Gabriella de Paula Marcondes Ferreira Leite, Alexandre Marcio Marcolino, Carlos Eduardo Pinfildi, Sérgio Britto Garcia, João Eduardo de Araújo, Elaine Caldeira de Oliveira Guirro
The aim of this study was to investigate the effect of laser photobiomodulation (PBM) on the viability of the transverse rectus abdominis musculocutaneous (TRAM) flap in rats subjected to the action of nicotine. We evaluated 60 albino Wistar rats, divided into six groups of ten animals. Group 1 (saline) underwent the surgical technique to obtain a TRAM flap; group 2 (laser 830 nm) underwent the surgical technique and was irradiated with a laser 830 nm; group 3 (laser 660 nm) underwent the surgical technique and was irradiated with a laser 660 nm; group 4 was treated with nicotine subcutaneously (2 mg/kg/2×/day/4 weeks) and underwent surgery; group 5 (nicotine + laser 830 nm) was exposed to nicotine, underwent the surgical technique, and was irradiated with a laser 830 nm; group 6 (nicotine + laser 660 nm) was exposed to nicotine, underwent the surgical technique, and was irradiated with a laser 660 nm...
December 2, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27913014/characterizations-of-atmospheric-particulate-bound-mercury-in-the-kathmandu-valley-of-nepal-south-asia
#17
Junming Guo, Shichang Kang, Jie Huang, Qianggong Zhang, Maheswar Rupakheti, Shiwei Sun, Lekhendra Tripathee, Dipesh Rupakheti, Arnico K Panday, Mika Sillanpää, Rukumesh Paudyal
The Kathmandu Valley, located in the Himalayan foothills in Nepal, is heavily polluted. In order to investigate ambient particulate-bound mercury (Hg) in the Kathmandu Valley, a total 64 total suspended particulates (TSP) samples were collected from a sub-urban site in the Kathmandu Valley, the capital region of Nepal during a sampling period of an entire year (April 2013-April 2014). They were analyzed for ambient particulate-bound Hg (PBM) using thermal desorption combined with cold vapor atomic spectroscopy...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27889422/symptomatic-pancreatic-duct-stones-in-the-disconnected-bile-duct-a-case-series
#18
Alexander R Ende, Shayan Irani, Richard A Kozarek
BACKGROUND: Pancreaticobiliary maljunction (PBM) refers to the union of the pancreatic and biliary ducts outside of the duodenal wall. Patients are at increased risk of bile duct and gallbladder cancer, likely secondary to pancreatic juice refluxing into the biliary tree, and it is recommended that they undergo biliary diversion. METHODS: This is a case series of all patients in our institution with PBM and bilioenteric anastomosis who presented with symptomatic pancreatic duct stones in a disconnected bile duct...
November 14, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27887804/the-effect-of-photobiomodulation-on-chemotherapy-induced-peripheral-neuropathy-a-randomized-sham-controlled-clinical-trial
#19
Peter A Argenta, Karla V Ballman, Melissa A Geller, Linda F Carson, Rahel Ghebre, Sally A Mullany, Deanna G K Teoh, Boris J N Winterhoff, Colleen L Rivard, Britt K Erickson
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer therapy with few efficacious treatments. METHODS: We enrolled 70 patients with CIPN in a randomized, double-blinded, sham-controlled, cross-over trial to determine if photobiomodulation (PBM)±physiotherapy reduced the symptoms of neuropathy compared to sham treatment. At the conclusion of follow-up, sham-arm patients could cross-over into a third arm combining PBM and physiotherapy to determine if multimodal treatment had additive effects...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27874264/photobiomodulation-in-human-muscle-tissue-an-advantage-in-sports-performance
#20
Cleber Ferraresi, Ying-Ying Huang, Michael R Hamblin
Photobiomodulation (PBM) describes the use of red or near-infrared (NIR) light to stimulate, heal, and regenerate damaged tissue. Both preconditioning (light delivered to muscles before exercise) and PBM applied after exercise can increase sports performance in athletes. This review covers the effects of PBM on human muscle tissue in clinical trials in volunteers related to sports performance and in athletes. The parameters used were categorized into those with positive effects or no effects on muscle performance and recovery...
December 2016: Journal of Biophotonics
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