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https://www.readbyqxmd.com/read/28723936/social-sensing-of-urban-land-use-based-on-analysis-of-twitter-users-mobility-patterns
#1
Aiman Soliman, Kiumars Soltani, Junjun Yin, Anand Padmanabhan, Shaowen Wang
A number of recent studies showed that digital footprints around built environments, such as geo-located tweets, are promising data sources for characterizing urban land use. However, challenges for achieving this purpose exist due to the volume and unstructured nature of geo-located social media. Previous studies focused on analyzing Twitter data collectively resulting in coarse resolution maps of urban land use. We argue that the complex spatial structure of a large collection of tweets, when viewed through the lens of individual-level human mobility patterns, can be simplified to a series of key locations for each user, which could be used to characterize urban land use at a higher spatial resolution...
2017: PloS One
https://www.readbyqxmd.com/read/28723727/longitudinal-analysis-of-motor-symptoms-and-histopathology-in-woozy-mice-a-model-of-cerebellar-ataxia
#2
Takemitsu Hayashi, Tomoya Onozato, Isao Wanajo, Morimichi Hayashi, Hiroo Takeda, Yoshikazu Fujimori
Woozy (wz) mice develop ataxia and carry a mutation in the Sil1 gene. Homozygous wz mice have been characterized histopathologically, but no details of their motor function have been reported. In the present study, to comprehensively understand the relationship between symptomatic progression and pathological feature, we evaluated motor function and neurodegeneration with age from presymptomatic to terminal stages. We evaluated the motor function of homozygous and heterozygous wz mice aged from 5 to 71 weeks...
July 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28721616/the-mining-sector-of-liberia-current-practices-and-environmental-challenges
#3
EDITORIAL
Samuel T K Wilson, Hongtao Wang, Martin Kabenge, Xuejiao Qi
Liberia is endowed with an impressive stock of mineral reserves and has traditionally relied on mining, namely iron ore, gold, and diamonds, as a major source of income. The recent growth in the mining sector has the potential to contribute significantly to employment, income generation, and infrastructure development. However, the development of these mineral resources has significant environmental impacts that often go unnoticed. This paper presents an overview of the Liberian mining sector from historical, current development, and economic perspectives...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28719545/social-media-in-pediatric-orthopaedics
#4
Sarah T Lander, James O Sanders, Peter C Cook, Natasha T O'Malley
BACKGROUND: Internet searches and social media utilization in health care has exploded over the past 5 years, and patients utilize it to gain information on their health conditions and physicians. Social media has the potential to serve as a means for education, communication, and marketing in all health care specialties. Physicians are sometimes reluctant to engage because of concerns of privacy, litigation, and lack of experience with this modality. Many surgical subspecialties have capitalized on social media but no study to date has examined the specific footprint of pediatric orthopaedic surgeons in this realm...
July 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28719193/relationships-between-atmospheric-transport-regimes-and-pcb-concentrations-in-air-at-zeppelin-spitsbergen
#5
Sandy Ubl, Martin Scheringer, Konrad Hungerbühler
Polychlorinated biphenyls (PCBs) are persistent hazardous chemicals that are still detected in the atmosphere and other environmental media although their production has been banned for several decades. At the long-term monitoring site, Zeppelin at Spitsbergen, different PCB congeners have been continuously measured for more than a decade. However, it is not clear what factors determine the seasonal and inter-annual variability of different (lighter vs. heavier) PCB congeners. To investigate the influence of atmospheric transport patterns on PCB-28 and PCB-101 concentrations at Zeppelin, we applied the Lagrangian Particle Dispersion Model FLEXPART and calculated "footprints'' that indicate the potential source regions of air arriving at Zeppelin...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28719007/validating-activity-indices-from-camera-traps-for-commensal-rodents-and-other-wildlife-in-and-around-farm-buildings
#6
Mark Lambert, Fiona Bellamy, Richard Budgey, Rebecca Callaby, Julia Coats, Janet Talling
BACKGROUND: Indices of rodent activity are used as indicators of population change during field evaluation of rodenticides. We investigated the potential for using camera traps to determine activity indices for commensal rodents living in and around farm buildings, and sought to compare these indices against previously calibrated survey methods. RESULTS: We recorded 41, 263 images of 23 species including Norway rats (Rattus norvegicus Berk.) and house mice (Mus musculus L...
July 18, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28717607/arthroscopic-trans-osseous-rotator-cuff-repair
#7
Claudio Chillemi, Matteo Mantovani
BACKGROUND: Mechanical factors are at the basis of any tendon healing process, being pressure an aspect able to positively influence it. For this reason transosseous rotator cuff repair represents the gold standard procedure for patients affected by a cuff tear, maximizing the tendon footprint contact area and reducing motion at the tendon to bone interface. METHODS: The Authors present an all arthroscopic suture bridge-like transosseous repair with the preparation of a single transosseous tunnel perfor med thanks to a precise dedicated instrument (Compasso®) and one implant (Elite-SPK®) with the use of only 3 suture wires...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28715365/analysis-of-the-c-kit-ligand-promoter-using-chromatin-immunoprecipitation
#8
Pingyu Zhang, Andres Rojas, Boris Blechacz
Multiple cellular processes, including DNA replication and repair, DNA recombination, and gene expression, require interactions between proteins and DNA. Therefore, DNA-protein interactions regulate multiple physiological, pathophysiological, and biological functions, such as cell differentiation, cell proliferation, cell cycle control, chromosome stability, epigenetic gene regulation, and cell transformation. In eukaryotic cells, the DNA interacts with histone and nonhistone proteins and is condensed into chromatin...
June 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28712973/occurrence-of-lutzomyia-longipalpis-lutz-neiva-1912-and-cerdocyon-thous-linnaeus-1977-in-a-visceral-leishmaniasis-endemic-area-in-brazil
#9
Maria Regiane Araujo Soares, Jadson Emanuel Lopes Antunes, Ivete Lopes de Mendonça, Rogério Nora Lima, Carlos Henrique Nery Costa
Cerdocyon thous presents a wide geographic distribution in Brazil and its role as a possible Leishmania infantum reservoir in a visceral leishmaniasis (VL) transmission cycle regardless of dogs (Canis familiaris) has been discussed. From this perspective, this work describes the occurrence and use of the habitat by Cerdocyon thous in a Lutzomyia longipalpis occurrence area Teresina (Piaui - Brazil), VL endemic region. Three specimens of C. thous were monitored with the use of radio telemetry and trails and footprints, seeking to find possible natural dens in order to collect the sanflies from the site...
July 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28712812/peroxynitrite-footprint-in-circulating-neutrophils-of-abdominal-aortic-aneurysm-patients-is-lower-in-statin-than-in-non-statin-users
#10
M E Groeneveld, J J van der Reijden, G J Tangelder, L C Westin, L Renwarin, R J P Musters, W Wisselink, K K Yeung
OBJECTIVES: Extensive reactive oxygen and nitrogen species (also reactive species) production is a mechanism involved in abdominal aortic aneurysm (AAA) development. White blood cells (WBCs) are a known source of reactive species. Their production may be decreased by statins, thereby reducing the AAA growth rate. Reactive species production in circulating WBCs of AAA patients and the effect of statins on their production was investigated. METHODS: This observational study investigated reactive species production in vivo and ex vivo in circulating WBCs of AAA patients, using venous blood from patients prior to elective AAA repair (n = 34; 18 statin users) and from healthy volunteers (n = 10)...
July 14, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28712501/gene-editing-in-polyploid-crops-wheat-camelina-canola-potato-cotton-peanut-sugar-cane-and-citrus
#11
Donald P Weeks
Polyploid crops make up a significant portion of the major food and fiber crops of the world and include wheat, potato, cotton, apple, peanut, citrus, and brassica oilseeds such as rape, canola, and Camelina. The presence of three sets of chromosomes in triploids, four sets in tetraploids, and six sets in hexaploids present significant challenges to conventional plant breeding and, potentially, to efficient use of rapidly emerging gene and genome-editing systems such as zinc finger nucleases, single-stranded oligonucleotides, TALE effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR/Cas9)...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28712026/posterior-cruciate-ligament-is-twisted-and-flat-structure-new-prospective-on-anatomical-morphology
#12
Tomohiro Kato, Robert Śmigielski, Yunshen Ge, Urszula Zdanowicz, Bogdan Ciszek, Mitsuo Ochi
PURPOSE: This cadaveric study aimed to elucidate PCL morphology by observing the anatomical relationship with other structures and the fibre layers of the PCL in cross section for remnant preserving PCL reconstruction. METHODS: Seventeen fresh-frozen cadaveric knees were studied, using the clock-face method to analyse the anatomical relationship between the PCL and Humphrey's ligament. The width and thickness of the PCL, Humphrey's and Wrisberg's ligaments were measured...
July 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28711684/folding-of-the-silver-aptamer-in-a-dnazyme-probed-by-2-aminopurine-fluorescence
#13
Runjhun Saran, Lu Yao, Peter Hoang, Juewen Liu
The RNA-cleaving Ag10c DNAzyme was recently isolated via in vitro selection and it can bind two Ag(+) ions for activity. The Ag10c contains a well-defined Ag(+) binding aptamer as indicated by DMS footprinting. Since aptamer binding is often accompanied with conformational changes, we herein used 2-aminopurine (2AP) to probe its folding in the presence of Ag(+). The Ag10c was respectively labeled with 2AP at three different positions, both in the substrate strand and in the enzyme strand. Ag(+)-induced folding was observed at the substrate cleavage junction and the A9 position of the enzyme strand, consistent with aptamer binding...
July 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28710628/%C3%AE-sitosterol-bioconversion-to-androstenedione-in-microtiter-plates
#14
Marco P C Marques, Pedro Fernandes
Microtiter plates are routinely used as low-cost miniaturized bioreactors due to the large number of experiments that can be conducted simultaneously under similar conditions and replicate all functions of bench-scale reactors at dramatically smaller volumes. These plates, due to the standard footprint, can be integrated with liquid-handling systems and associated equipment expanding considerably their application and use. However, care has to be taken to operate the microtiter plates in optimized mixing and oxygen transfer conditions, preventing medium evaporation in prolonged experiment runs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28708998/profiling-ssb-nascent-chain-interactions-reveals-principles-of-hsp70-assisted-folding
#15
Kristina Döring, Nabeel Ahmed, Trine Riemer, Harsha Garadi Suresh, Yevhen Vainshtein, Markus Habich, Jan Riemer, Matthias P Mayer, Edward P O'Brien, Günter Kramer, Bernd Bukau
The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent polypeptides to assist protein folding. To reveal its working principle, we determined the nascent chain-binding pattern of Ssb at near-residue resolution by in vivo selective ribosome profiling. Ssb associates broadly with cytosolic, nuclear, and hitherto unknown substrate classes of mitochondrial and endoplasmic reticulum (ER) nascent proteins, supporting its general chaperone function. Ssb engages most substrates by multiple binding-release cycles to a degenerate sequence enriched in positively charged and aromatic amino acids...
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28708617/using-one-filter-stage-of-unsaturated-saturated-vertical-flow-filters-for-nitrogen-removal-and-footprint-reduction-of-constructed-wetlands
#16
Ania Morvannou, Stéphane Troesch, Dirk Esser, Nicolas Forquet, Alain Petitjean, Pascal Molle
French vertical flow constructed wetlands (VFCW) treating raw wastewater have been developed successfully over the last 30 years. Nevertheless, the two-stage VFCWs require a total filtration area of 2-2.5 m(2)/P.E. Therefore, implementing a one-stage system in which treatment performances reach standard requirements is of interest. Biho-Filter(®) is one of the solutions developed in France by Epur Nature. Biho-Filter(®) is a vertical flow system with an unsaturated layer at the top and a saturated layer at the bottom...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28708428/reliability-and-correlation-of-static-and-dynamic-foot-arch-measurement-in-a-healthy-pediatric-population
#17
Karsten Hollander, Timo Scholz, Astrid Zech, Karl Wegscheider, Susanne Lezius, Klaus-Michael Braumann, Susanne Sehner
BACKGROUND: The measurement of the medial longitudinal foot arch in children is a controversial topic, as there are many different methods without a definite gold-standard. The purpose of this study was to 1) investigate intra-day- and inter-rater-reliability regarding dynamic arch index and static arch height, 2) to explore the correlation between both arch indices and 3) to examine the variation of the medial longitudinal arch at two different times of the day. METHODS: Eighty-six children (age 8...
July 14, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28708131/a-clinicopathological-approach-to-the-diagnosis-of-dementia
#18
REVIEW
Fanny M Elahi, Bruce L Miller
The most definitive classification systems for dementia are based on the underlying pathology which, in turn, is categorized largely according to the observed accumulation of abnormal protein aggregates in neurons and glia. These aggregates perturb molecular processes, cellular functions and, ultimately, cell survival, with ensuing disruption of large-scale neural networks subserving cognitive, behavioural and sensorimotor functions. The functional domains affected and the evolution of deficits in these domains over time serve as footprints that the clinician can trace back with various levels of certainty to the underlying neuropathology...
July 14, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28706849/all-intra-articular-arthroscopic-rotator-cuff-repair
#19
Pablo Ruben Rupenian
This Technical Note presents an arthroscopic technique to repair rotator cuff tears using a constant intra-articular (glenohumeral) portal for visualization. The smoothness of both the humeral head cartilage and the articular side of the rotator cuff offers a cleaner arthroscopic approach, while the absence of a subacromial bursa also reduces bleeding, turbidity, and the need for iterative soft tissue debridement. It also facilitates the recognition and repair of certain tear patterns. The intra-articular perspective allows the surgeon to visualize how stitches pierce the tissue in a desired and resistant area of the tendon...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28706801/combined-anatomic-reconstruction-of-the-anterior-cruciate-and-anterolateral-ligaments-using-hamstring-graft-through-a-single-femoral-tunnel-and-with-a-single-femoral-fixation
#20
Assem Mohamed Noureldin Zein, Mohamed Ali, Hesham Ali, Ahmed Nady Saleh Elsaid, Alaa Zenhom Mahmoud, Mohamed K Osman, Amr Mohamed Mohamed Soliman
Patients with complete anterior cruciate ligament (ACL) injury have different degrees of rotational (internal rotation) laxity. A residual pivot shift has been found to be positive in more than 15% of cases after an accurate ACL reconstruction. Improved understanding of the existence, function, and biomechanical role of the anterolateral ligament (ALL) in controlling rotational instability of the knee has redirected and refocused attention on a supplemental extra-articular reconstruction of the ALL in conjunction with the intra-articular ACL reconstruction so as to restore normal kinematics of the knee...
June 2017: Arthroscopy Techniques
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