keyword
MENU ▼
Read by QxMD icon Read
search

lower respiratory tract infection

keyword
https://www.readbyqxmd.com/read/29655388/the-prevalence-of-healthcare-associated-infections-in-mainland-china-a-systematic-review-and-meta-analysis
#1
Jiancong Wang, Fangfei Liu, Ermira Tartari, Jianan Huang, Stephan Harbarth, Didier Pittet, Walter Zingg
OBJECTIVETo assess the prevalence of healthcare-associated infections (HAIs) in mainland China.DESIGNSystematic review and meta-analysis.SETTINGAdults and children from secondary and tertiary acute-care hospitals in mainland China.METHODSWe searched PubMed, the China National Knowledge Infrastructure, and Wan Fang for multicenter point-prevalence surveys of acute-care hospitals in mainland China from January 2006 to August 2016. All reports related to HAI, using a point-prevalence methodology and published either in English or Chinese were eligible...
April 15, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29628891/training-load-immune-status-and-clinical-outcomes-in-young-athletes-a-controlled-prospective-longitudinal-study
#2
Katharina Blume, Nina Körber, Dieter Hoffmann, Bernd Wolfarth
Introduction: Beside positive effects on athlete's health, competitive sport can be linked with an increased risk of illness and injury. Because of high relative increases in training, additional physical and psychological strains, and an earlier specialization and professionalization, adolescent athletes needs an increased attention. Training can alter the immune system by inducing a temporary immunosuppression, finally developing infection symptoms. Previous studies identified Epstein Barr Virus (EBV) as potential indicator for the immune status...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29628378/pegvaliase-for-the-treatment-of-phenylketonuria-a-pivotal-double-blind-randomized-discontinuation-phase-3-clinical-trial
#3
Cary O Harding, R Stephen Amato, Mary Stuy, Nicola Longo, Barbara K Burton, John Posner, Haoling H Weng, Markus Merilainen, Zhonghua Gu, Joy Jiang, Jerry Vockley
INTRODUCTION: Pegvaliase is a recombinant Anabaena variabilis phenylalanine ammonia lyase (PAL) enzyme under investigation for treatment of adult phenylketonuria (PKU). This manuscript describes results of a randomized discontinuation trial (RDT) designed to evaluate the effects of pegvaliase treatment on blood phenylalanine (Phe) and neuropsychiatric outcomes in adults with PKU. METHODS: PRISM-2 is a 4-part, Phase 3 study that enrolled adults with PKU receiving pegvaliase treatment (initiated in a prior Phase 2 or Phase 3 study)...
March 18, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29627936/invasive-fungal-infections-associated-with-prior-respiratory-viral-infections-in-immunocompromised-hosts
#4
Saira Ajmal, Maryam Mahmood, Omar Abu Saleh, Jenifer Larson, M Rizwan Sohail
BACKGROUND: Increased risk of invasive pulmonary aspergillosis after influenza infection has been reported; however data are limited. PURPOSE: To describe Invasive fungal infections (IFI) associated with preceding respiratory viral infection at a large referral center. METHODS: We reviewed all IFI cases among patients with positive influenza and/or RSV nasopharyngeal/lower respiratory tract PCR from October 2015 to December 2016. Cases of pulmonary IFI were classified as possible, probable, and definite based on EORTC-MSG definitions...
April 7, 2018: Infection
https://www.readbyqxmd.com/read/29626210/the-life-cycle-of-non-polio-enteroviruses-and-how-to-target-it
#5
REVIEW
Jim Baggen, Hendrik Jan Thibaut, Jeroen R P M Strating, Frank J M van Kuppeveld
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a variety of diseases, including non-specific febrile illness, hand-foot-and-mouth disease, neonatal sepsis-like disease, encephalitis, paralysis and respiratory diseases. In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. These include EV-A71, which has caused epidemics of hand-foot-and-mouth disease in Southeast Asia, and EV-D68, which recently caused a large outbreak of severe lower respiratory tract disease in North America...
April 6, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29625943/drug-utilization-and-prescribing-pattern-of-antibiotics-in-a-tertiary-care-setups-trends-and-practices
#6
Huma Ali, Farya Zafar, Shazia Alam, Anwar Ejaz Beg, Rabia Bushra, Ammara Manzoor, Ghazala R Naqvi, Riffat Yasmeen, Yousra Shafiq, Anum Tariq, Saba Zubair, Saima Saleem
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29621602/neutrophil-extracellular-traps-possess-anti-human-respiratory-syncytial-virus-activity-possible-interaction-with-the-viral-f-protein
#7
Priscila Silva Sampaio Souza, Lia Vezenfard Barbosa, Larissa Figueiredo Alves Diniz, Gabriel Soares da Silva, Bruno Rafael Pereira Lopes, Pedro Miyadaira Ribeiro Souza, Gabriela Campos de Araujo, Diogo Pessoa, Juliana de Oliveira, Fátima Pereira Souza, Karina Alves Toledo
Human respiratory syncytial virus (hRSV) is one of the main etiological agents of diseases of the lower respiratory tract, and is often responsible for the hospitalization of children and the elderly. To date, treatments are only palliative and there is no vaccine available. The airways of patients infected with hRSV exhibit intense neutrophil infiltration, which is responsible for the release of neutrophil extracellular traps (NETs). These are extracellular structures consisting of DNA associated with intracellular proteins, and are efficient in capturing and eliminating various microorganisms, including some viruses...
April 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#8
Adriana Weinberg, Marisa Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, D Robert Harris, Christiana Smith, George Siberry
OBJECTIVES: To identify factors that predispose HIV-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization and death in the first 6 to 24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. DESIGN: Nested case-control study of 107 LRTI+ infants enrolled in the NISDI Perinatal and LILAC studies with and 140 LRTI- in the first 6 months of, matched by date and place of birth...
March 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29620628/the-significance-of-bacterial-engulfment-in-gram-stained-sputum-in-patients-with-respiratory-infections
#9
Masafumi Shimoda, Takeshi Saraya, Shota Yonetani, Koji Araki, Hajime Takizawa
In general, physicians believe that the presence of bacterial engulfment in white blood cells (WBCs) on Gram-stained sputum is a hallmark of lower respiratory infection. However, no studies have described the significance or diagnostic accuracy of engulfment in lower respiratory tract infections.We prospectively studied sputum samples by Gram staining (Favor method) for their quality and engulfment score in WBCs obtained from patients with respiratory symptoms at inpatient and outpatient settings at Kyorin University Hospital between December 2012 and April 2015...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619292/rate-of-antibiotic-prescriptions-in-german-outpatient-care-are-the-guidelines-followed-or-are-they-still-exceeded
#10
Janine Zweigner, Elisabeth Meyer, Petra Gastmeier, Frank Schwab
Aim: The consequences of antibiotic overuse are substantial. We combined and analyzed the infection diagnoses and antibiotic prescribing practices of physicians in outpatient settings. Recommendations for targeting policy efforts to focused areas are given. Methods: Antibiotic prescriptions and infections diagnosed were provided by a German statutory health insurance provider over a 12-month period. Antibiotic use was expressed as prescriptions per 100 patients. Results: 2,594,000 patient-physician contacts within twelve months were analyzed...
2018: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/29619212/validity-of-maternal-report-of-care-seeking-for-childhood-illness
#11
Emily D Carter, Micky Ndhlovu, Melinda Munos, Emmy Nkhama, Joanne Katz, Thomas P Eisele
Background: Accurate data on care-seeking for child illness are needed to improve public health programs and reduce child mortality. The accuracy of maternal report of care-seeking for child illness as collected through household surveys has not been validated. Methods: A 2016 survey compared reported care-seeking against a gold-standard of health care provider documented care-seeking events among a random sample of mothers of children <5 years in Southern Province, Zambia...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29619105/assessment-of-pulmonary-function-before-and-after-sinus-surgery-in-lung-transplant-recipients
#12
Bernardo Faria Ramos, Fábio de Rezende Pinna, Silvia Vidal Campos, José Eduardo Afonso Júnior, Ricardo Henrique de Oliveira Braga Teixeira, Rafael Medeiros Carraro, Richard Louis Voegels
Introduction  The association between sinus and lung diseases is well known. However, there are scarce studies regarding the effects of sinus surgery on pulmonary function in lung transplant recipients. The present study describes our experience with sinus surgery in lung transplant recipients with chronic rhinosinusitis. Objectives  To assess the impact of sinus surgery for chronic rhinosinusitis on pulmonary function and on inpatient hospitalization days due to lower respiratory tract infection in lung transplant recipients...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29618942/genetic-diversity-of-human-respiratory-syncytial-virus-isolated-among-children-with-acute-respiratory-infections-in-southern-cameroon-during-three-consecutive-epidemic-seasons-2011-2013
#13
Sebastien Kenmoe, Marie-Astrid Vernet, Fabien Miszczak, Julia Dina, Matthieu Schoenhals, Véronique Penlap Beng, Astrid Vabret, Richard Njouom
Background: Human respiratory syncytial virus (HRSV) is the main viral cause of severe lower respiratory tract disease in infants and young children. The aim of this study was to describe for the first time the genetic variability of HRSV in Cameroonian patients living in Yaounde for three consecutive epidemic seasons. Methods: HRSV-positive nasopharyngeal samples detected in children less than 15 years in Yaounde were collected from September 2011 to December 2013...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29617879/prevalence-and-significance-of-substitutions-in-the-fusion-protein-of-respiratory-syncytial-virus-resulting-in-neutralization-escape-from-antibody-medi8897
#14
Qing Zhu, Bin Lu, Patrick McTamney, Susan Palaszynski, Seme Diallo, Kuishu Ren, Nancy D Ulbrandt, Nicole Kallewaard, Weijia Wang, Fiona Fernandes, Steve Wong, Catherine Svabek, Brian Moldt, Mark T Esser, Hong Jing, JoAnn A Suzich
Background: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children. To date, no vaccine is approved for the broad population of healthy infants. MEDI8897, a potent anti-RSV fusion antibody with extended serum half-life is currently under clinical investigation as a potential passive RSV vaccine for all infants. As an RNA virus, RSV is prone to mutation, the possibility of viral escape from MEDI8897 neutralization is a potential concern...
March 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29617859/human-lung-epithelial-cells-support-human-metapneumovirus-persistence-by-overcoming-apoptosis
#15
Stefania Marsico, Francesca Caccuri, Pietro Mazzuca, Paola Apostoli, Sara Roversi, Giovanni Lorenzin, Alberto Zani, Simona Fiorentini, Cinzia Giagulli, Arnaldo Caruso
Human metapneumovirus (hMPV) has been identified as a major cause of lower respiratory tract infection in children. Epidemiological and molecular evidence has highlighted an association between severe childhood respiratory viral infection and chronic lung diseases, such as asthma and chronic obstructive pulmonary disease. Currently, animal models have demonstrated the ability of hMPV to persist in vivo suggesting a role of the virus in asthma development in children. However, mechanisms involved in hMPV persistence in the respiratory tract are not yet understood...
March 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29617814/a-respiratory-syncytial-virus-vaccine-based-on-the-small-hydrophobic-protein-ectodomain-presented-with-a-novel-lipid-based-formulation-is-highly-immunogenic-and-safe-in-adults-a-first-in-humans-study
#16
Joanne M Langley, Lisa D MacDonald, Genevieve M Weir, Donna MacKinnon-Cameron, Lingyun Ye, Shelly McNeil, Bert Schepens, Xavier Saelens, Marianne M Stanford, Scott A Halperin
Background: Respiratory Syncytial Virus infection can cause lower respiratory tract infection in older adults comparable to influenza, but no vaccines are available. Methods: This was a randomized, observer blinded first-in-humans study of a novel synthetic RSV antigen SHe, formulated with either the lipid and oil-based vaccine platform, DepoVaxTM, termed DPX-RSV(A), or with alum, termed (RSV(A) SHe, in healthy 50-64-year-old adults. Two dose levels (10 or 25 µg) of the SHe antigen with each formulation were compared to placebo...
March 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29611493/nosocomial-outbreak-of-upper-respiratory-tract-infection-with-%C3%AE-lactamase-negative-ampicillin-resistant-nontypeable-haemophilus-influenzae
#17
Reiko Miyahara, Motoi Suzuki, Konosuke Morimoto, Bin Chang, Sayaka Yoshida, Shiori Yoshinaga, Miki Kitamura, Mikiko Chikamori, Kazunori Oishi, Tatsuhiko Kitamura, Masayuki Ishida
OBJECTIVETo describe the epidemiologic features of an outbreak of an acute respiratory tract infection (ARI) caused by β-lactamase-negative ampicillin-resistant (BLNAR) nontypeable Haemophilus influenzae (NTHi) in an acute-care ward.DESIGNCross-sectional case-control study.SETTINGAn acute-care ward (ward A) in a general hospital of Kochi in western Japan.METHODSPatients who shared a room with an index patient and all staff in ward A were screened and followed from July 1 to August 31, 2015. Sputum or throat swab samples were collected from participants and tested by culture and polymerase chain reaction (PCR)...
April 3, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29610624/dyspnea-in-children-as-a-symptom-of-acute-respiratory-tract-infections-and-antibiotic-prescribing
#18
Valentina Risteska-Nejashmikj, Snezhana Stojkovska, Katarina Stavrikj
BACKGROUND: Dyspnea is an unpleasant feeling of breathing difficulty, shortness of breath and inability to satisfy the hunger for air. The role of family physicians is to be prepared to recognise dyspnea as a symptom of acute respiratory infections (ARI), to perform triage and managing of children with acute dyspnea and make continuous education of parents. In the treatment of acute dyspnea more important is to treat dyspnea as a symptom than the prescribing of antibiotics (AB). Nowadays, even more often large amount of children, because of the noncompliance in the treatment and the pressure from the parents, unnecessary is hospitalised and frequently used antibiotics: According to the guidelines, a small percentage of children with ARI should be treated with AB...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29604109/procalcitonin-monitoring-as-a-guide-for-antimicrobial-therapy-a-review-of-current-literature
#19
Elizabeth W Covington, Megan Z Roberts, Jenny Dong
Effective antimicrobial stewardship practices are increasingly essential to best utilize the current arsenal of antimicrobials for the shortest necessary duration to minimize the development of antimicrobial resistance, secondary infections, and health care costs. Monitoring of serum procalcitonin (PCT) levels represents an effective antimicrobial stewardship strategy to differentiate bacterial infections from viral infections and noninfectious inflammatory conditions. Current literature illustrates the merits of PCT monitoring in reducing duration of antibiotic therapy without detrimental effects on mortality or infection relapses...
March 31, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29603792/mid-regional-pro-adrenomedullin-could-be-a-biomarker-of-severity-in-bronchiolitis
#20
Mercedes Bueno Campaña, Marta Rupérez Lucas, Adelaida Fernández Rincon, Cristina Calvo, Lucia Moran Roldan, Rocío de la Morena Martinez
Acute bronchiolitis is the most common lower respiratory tract infection in infants and an important cause of hospital admissions. In the initial course of the disease there are no clinical or analytical parameters that can accurately predict disease severity. Classifying patients as high or low risk for a more severe outcome would improve the optimisation of resources. This article is protected by copyright. All rights reserved.
March 30, 2018: Acta Paediatrica
keyword
keyword
51246
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"