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https://www.readbyqxmd.com/read/28534399/self-assembly-of-organic-ferroelectrics-by-evaporative-dewetting-a-case-of-%C3%AE-glycine
#1
Ensieh Seyedhosseini, Konstantin Romanyuk, Daria Vasileva, Semen Vasilev, Alla Nuraeva, Pavel Zelenovskiy, Maxim S Ivanov, Anna N Morozovska, Vladimir Ya Shur, Haidong Lu, Alexei Gruverman, Andrei Leonidovitch Kholkin
Self-assembly of ferroelectric materials attracts significant interest because it offers a promising fabrication route to novel structures useful for microelectronic devices such as non-volatile memories, integrated sensors/actuators, or energy harvesters. In this work, we demonstrate a novel approach for self-assembly of organic ferroelectrics (as exemplified by ferroelectric β-glycine) using evaporative dewetting, which allows forming quasi-regular arrays of nano- and microislands with preferred orientation of polarization axes...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28514967/at1-receptor-response-to-non-saturating-ang-ii-concentrations-is-amplified-by-calcium-channel-blockers
#2
Kristoffer Bernhem, Kalaiselvan Krishnan, Alexander Bondar, Hjalmar Brismar, Anita Aperia, Lena Scott
BACKGROUND: Blockers of angiotensin II type 1 receptor (AT1R) and the voltage gated calcium channel 1.2 (CaV1.2) are commonly used for treatment of hypertension. Yet there is little information about the effect of physiological concentrations of angiotensin II (AngII) on AT1R signaling and whether there is a reciprocal regulation of AT1R signaling by CaV1.2. METHODS: To elucidate these questions, we have studied the Ca(2+) signaling response to physiological and pharmacological AngII doses in HEK293a cells, vascular smooth muscle cells and cardiomyocytes using a Ca(2+) sensitive dye as the principal sensor...
May 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28514017/isopimaric-acid-a-multi-targeting-ion-channel-modulator-reducing-excitability-and-arrhythmicity-in-a-spontaneously-beating-mouse-atrial-cell-line
#3
Sajjad Salari, Malin Silverå Ejneby, Johan Brask, Fredrik Elinder
AIM: Atrial fibrillation is the most common persistent cardiac arrhythmia, and it is not well controlled by present drugs. Because some resin acids open voltage-gated potassium channels and reduce neuronal excitability, we explored the effects of the resin acid isopimaric acid (IPA) on action potentials and ion currents in cardiomyocytes. METHODS: Spontaneously beating mouse atrial HL-1 cells were investigated with the whole-cell patch-clamp technique. RESULTS: 1-25 μmol L(-1) IPA reduced the action potential frequency by up to 50%...
May 17, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28508759/mri-trus-fusion-for-electrode-positioning-during-irreversible-electroporation-for-treatment-of-prostate-cancer
#4
Alexander D J Baur, Federico Collettini, Judith Enders, Andreas Maxeiner, Vera Schreiter, Carsten Stephan, Bernhard Gebauer, Bernd Hamm, Thomas Fischer
We aimed to introduce an approach for image-guided positioning of electrodes for irreversible electroporation (IRE) in patients with prostate cancer using a magnetic resonance imaging-transrectal ultrasonography (MRI-TRUS) fusion technique. In 10 consecutive patients with biopsy-proven Gleason score ≤3+4 prostate cancer, 19 G electrodes were inserted into the prostate using a transperineal access. Magnetic resonance images of the prostate acquired before IRE were fused with transrectal ultrasound images acquired during IRE...
May 15, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28507132/identification-of-cav2-pkc%C3%AE-and-cav2-nos1-complexes-as-entities-for-ultrafast-electrochemical-coupling
#5
Cristina E Constantin, Catrin S Müller, Michael G Leitner, Wolfgang Bildl, Uwe Schulte, Dominik Oliver, Bernd Fakler
Voltage-activated calcium (Cav) channels couple intracellular signaling pathways to membrane potential by providing Ca(2+) ions as second messengers at sufficiently high concentrations to modulate effector proteins located in the intimate vicinity of those channels. Here we show that protein kinase Cβ (PKCβ) and brain nitric oxide synthase (NOS1), both identified by proteomic analysis as constituents of the protein nano-environment of Cav2 channels in the brain, directly coassemble with Cav2.2 channels upon heterologous coexpression...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28505078/intra-minute-cloud-passing-forecasting-based-on-a-low-cost-iot-sensor-a-solution-for-smoothing-the-output-power-of-pv-power-plants
#6
Primož Sukič, Gorazd Štumberger
Clouds moving at a high speed in front of the Sun can cause step changes in the output power of photovoltaic (PV) power plants, which can lead to voltage fluctuations and stability problems in the connected electricity networks. These effects can be reduced effectively by proper short-term cloud passing forecasting and suitable PV power plant output power control. This paper proposes a low-cost Internet of Things (IoT)-based solution for intra-minute cloud passing forecasting. The hardware consists of a Raspberry PI Model B 3 with a WiFi connection and an OmniVision OV5647 sensor with a mounted wide-angle lens, a circular polarizing (CPL) filter and a natural density (ND) filter...
May 13, 2017: Sensors
https://www.readbyqxmd.com/read/28504937/ultrasonic-fingerprint-sensor-with-transmit-beamforming-based-on-a-pmut-array-bonded-to-cmos-circuitry
#7
Xiaoyue Jiang, Hao-Yen Tang, Yipeng Lu, Eldwin Ng, Julius Tsai, Bernhard Boser, David Horsley
In this paper, we present a single-chip 65x42 element ultrasonic pulse-echo fingerprint sensor with transmit beamforming based on piezoelectric micromachined ultrasonic transducers (PMUTs) directly bonded to a CMOS readout ASIC. The readout ASIC was realized in a standard 180 nm CMOS process with a 24V high voltage transistor option. Pulse-echo measurements are performed column-by-column in sequence using either one column or five columns to transmit the ultrasonic pulse at 20 MHz. Transmit beamforming is used to focus the ultrasonic beam at the imaging plane where the finger is located, increasing the ultrasonic pressure and narrowing the 3dB beam-width to 50 microns, a factor of 6...
May 11, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28502782/time-resolved-x-ray-solution-scattering-reveals-the-structural-photoactivation-of-a-light-oxygen-voltage-photoreceptor
#8
Oskar Berntsson, Ralph P Diensthuber, Matthijs R Panman, Alexander Björling, Ashley J Hughes, Léocadie Henry, Stephan Niebling, Gemma Newby, Marianne Liebi, Andreas Menzel, Robert Henning, Irina Kosheleva, Andreas Möglich, Sebastian Westenhoff
Light-oxygen-voltage (LOV) receptors are sensory proteins controlling a wide range of organismal adaptations in multiple kingdoms of life. Because of their modular nature, LOV domains are also attractive for use as optogenetic actuators. A flavin chromophore absorbs blue light, forms a bond with a proximal cysteine residue, and induces changes in the surroundings. There is a gap of knowledge on how this initial signal is relayed further through the sensor to the effector module. To characterize these conformational changes, we apply time-resolved X-ray scattering to the homodimeric LOV domain from Bacillus subtilis YtvA...
May 8, 2017: Structure
https://www.readbyqxmd.com/read/28491905/genetically-expressed-voltage-sensor-arclight-for-imaging-large-scale-cortical-activity-in-the-anesthetized-and-awake-mouse
#9
Peter Y Borden, Alex D Ortiz, Christian Waiblinger, Audrey J Sederberg, Arthur E Morrissette, Craig R Forest, Dieter Jaeger, Garrett B Stanley
With the recent breakthrough in genetically expressed voltage indicators (GEVIs), there has been a tremendous demand to determine the capabilities of these sensors in vivo. Novel voltage sensitive fluorescent proteins allow for direct measurement of neuron membrane potential changes through changes in fluorescence. Here, we utilized ArcLight, a recently developed GEVI, and examined the functional characteristics in the widely used mouse somatosensory whisker pathway. We measured the resulting evoked fluorescence using a wide-field microscope and a CCD camera at 200 Hz, which enabled voltage recordings over the entire cortical region with high temporal resolution...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28486405/compensation-of-pvt-variations-in-tof-imagers-with-in-pixel-tdc
#10
Ion Vornicu, Ricardo Carmona-Galán, Ángel Rodríguez-Vázquez
The design of a direct time-of-flight complementary metal-oxide-semiconductor (CMOS) image sensor (dToF-CIS) based on a single-photon avalanche-diode (SPAD) array with an in-pixel time-to-digital converter (TDC) must contemplate system-level aspects that affect its overall performance. This paper provides a detailed analysis of the impact of process parameters, voltage supply, and temperature (PVT) variations on the time bin of the TDC array. Moreover, the design and characterization of a global compensation loop is presented...
May 9, 2017: Sensors
https://www.readbyqxmd.com/read/28476084/sno2-nanostructures-effect-of-processing-parameters-on-their-structural-and-functional-properties
#11
Tetiana A Dontsova, Svitlana V Nagirnyak, Vladyslav V Zhorov, Yuriy V Yasiievych
Zero- and 1D (one-dimensional) tin (IV) oxide nanostructures have been synthesized by thermal evaporation method, and a comparison of their morphology, crystal structure, sorption properties, specific surface area, as well as electrical characteristics has been performed. Synthesized SnO2 nanomaterials were studied by X-ray diffraction, scanning and transmission electron microscopy (SEM and TEM), N2 sorption/desorption technique, IR spectroscopy and, in addition, their current-voltage characteristics have also been measured...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28475112/insect-active-toxins-with-promiscuous-pharmacology-from-the-african-theraphosid-spider-monocentropus-balfouri
#12
Jennifer J Smith, Volker Herzig, Maria P Ikonomopoulou, Sławomir Dziemborowicz, Frank Bosmans, Graham M Nicholson, Glenn F King
Many chemical insecticides are becoming less efficacious due to rising resistance in pest species, which has created much interest in the development of new, eco-friendly bioinsecticides. Since insects are the primary prey of most spiders, their venoms are a rich source of insect-active peptides that can be used as leads for new bioinsecticides or as tools to study molecular receptors that are insecticidal targets. In the present study, we isolated two insecticidal peptides, µ/ω-TRTX-Mb1a and -Mb1b, from venom of the African tarantula Monocentropus balfouri...
May 5, 2017: Toxins
https://www.readbyqxmd.com/read/28473752/spontaneous-ca-2-influx-in-drosophila-pupal-neurons-is-modulated-by-ip3-receptor-function-and-influences-maturation-of-the-flight-circuit
#13
Sumita Chakraborty, Gaiti Hasan
Inositol 1,4,5-trisphosphate receptors (IP3R) are Ca(2+) channels on the neuronal endoplasmic reticulum (ER) membrane. They are gated by IP3, produced upon external stimulation and activation of G protein-coupled receptors on the plasma membrane (PM). IP3-mediated Ca(2+) release, and the resulting depletion of the ER store, triggers entry of extracellular Ca(2+) by store-operated Ca(2+) entry (SOCE). Mutations in IP3R attenuate SOCE. Compromised IP3R function and SOCE during pupal development of Drosophila leads to flight deficits and mimics suppression of neuronal activity during pupal or adult development...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28469179/highly-selective-and-sensitive-self-powered-glucose-sensor-based-on-capacitor-circuit
#14
Gymama Slaughter, Tanmay Kulkarni
Enzymatic glucose biosensors are being developed to incorporate nanoscale materials with the biological recognition elements to assist in the rapid and sensitive detection of glucose. Here we present a highly sensitive and selective glucose sensor based on capacitor circuit that is capable of selectively sensing glucose while simultaneously powering a small microelectronic device. Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucose dehydrogenase (PQQ-GDH) and bilirubin oxidase (BOD) at anode and cathode, respectively, in the biofuel cell arrangement...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28469162/blue-light-reception-through-quaternary-transitions
#15
Christopher Engelhard, Ralph P Diensthuber, Andreas Möglich, Robert Bittl
Sensory photoreceptors absorb light via their photosensor modules and trigger downstream physiological adaptations via their effector modules. Light reception accordingly depends on precisely orchestrated interactions between these modules, the molecular details of which often remain elusive. Using electron-electron double resonance (ELDOR) spectroscopy and site-directed spin labelling, we chart the structural transitions facilitating blue-light reception in the engineered light-oxygen-voltage (LOV) histidine kinase YF1 which represents a paradigm for numerous natural signal receptors...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28463315/self-calibration-for-lensless-color-microscopy
#16
Olivier Flasseur, Corinne Fournier, Nicolas Verrier, Loïc Denis, Frédéric Jolivet, Anthony Cazier, Thierry Lépine
Lensless color microscopy (also called in-line digital color holography) is a recent quantitative 3D imaging method used in several areas including biomedical imaging and microfluidics. By targeting cost-effective and compact designs, the wavelength of the low-end sources used is known only imprecisely, in particular because of their dependence on temperature and power supply voltage. This imprecision is the source of biases during the reconstruction step. An additional source of error is the crosstalk phenomenon, i...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28452402/high-performance-piezoelectric-nanogenerators-with-imprinted-p-vdf-trfe-batio3-nanocomposite-micropillars-for-self-powered-flexible-sensors
#17
Xiaoliang Chen, Xiangming Li, Jinyou Shao, Ningli An, Hongmiao Tian, Chao Wang, Tianyi Han, Li Wang, Bingheng Lu
Piezoelectric nanogenerators with large output, high sensitivity, and good flexibility have attracted extensive interest in wearable electronics and personal healthcare. In this paper, the authors propose a high-performance flexible piezoelectric nanogenerator based on piezoelectrically enhanced nanocomposite micropillar array of polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE))/barium titanate (BaTiO3 ) for energy harvesting and highly sensitive self-powered sensing. By a reliable and scalable nanoimprinting process, the piezoelectrically enhanced vertically aligned P(VDF-TrFE)/BaTiO3 nanocomposite micropillar arrays are fabricated...
April 28, 2017: Small
https://www.readbyqxmd.com/read/28441740/a-miniature-aerosol-sensor-for-detecting-polydisperse-airborne-ultrafine-particles
#18
Chao Zhang, Dingqu Wang, Rong Zhu, Wenming Yang, Peng Jiang
Counting and sizing of polydisperse airborne nanoparticles have attracted most attentions owing to increasing widespread presence of airborne engineered nanoparticles or ultrafine particles. Here we report a miniature aerosol sensor to detect particle size distribution of polydisperse ultrafine particles based on ion diffusion charging and electrical detection. The aerosol sensor comprises a couple of planar electrodes printed on two circuit boards assembled in parallel, where charging, precipitation and measurement sections are integrated into one chip, which can detect aerosol particle size in of 30-500 nm, number concentration in range of 5 × 10²-10⁷ /cm³...
April 22, 2017: Sensors
https://www.readbyqxmd.com/read/28439415/stretchable-biofuel-cells-as-wearable-textile-based-self-powered-sensors
#19
Itthipon Jeerapan, Juliane R Sempionatto, Adriana Pavinatto, Jung-Min You, Joseph Wang
Highly stretchable textile-based biofuel cells (BFCs), acting as effective self-powered sensors, have been fabricated using screen-printing of customized stress-enduring inks. Due to synergistic effects of nanomaterial-based engineered inks and the serpentine designs, these printable bioelectronic devices endure severe mechanical deformations, e.g., stretching, indentation, or torsional twisting. Glucose and lactate BFCs with the single enzyme and membrane-free configurations generated the maximum power density of 160 and 250 µW cm(-2) with the open circuit voltages of 0...
December 21, 2016: Journal of Materials Chemistry. A, Materials for Energy and Sustainability
https://www.readbyqxmd.com/read/28436325/photoperiodic-responses-and-characterization-of-the-cmvvd-gene-encoding-a-blue-light-photoreceptor-from-the-medicinal-caterpillar-fungus-cordyceps-militaris-ascomycetes
#20
Xin Zhang, Xiaoming Dong, Xinhua Song, Fen Wang, Caihong Dong
Light is a necessary environmental factor for production of conidia and pigment, formation of stroma, and development of Cordyceps militaris, a well-known edible and medicinal mushroom. In this study, an obvious rhythm loop was observed in certain strains of C. militaris under conditions of alternating 12-hour intervals of dark and light. A possibly related gene, Cmvvd, the homologue of the blue-light photoreceptor of Neurospora crassa, was cloned from the genome of C. militaris. The protein CmVVD is predicted to be 203 amino acids in length and is characterized by the presence of a light, oxygen, or voltage domain...
2017: International Journal of Medicinal Mushrooms
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