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https://www.readbyqxmd.com/read/27913207/overexpression-of-stim1-in-neurons-in-mouse-brain-improves-contextual-learning-and-impairs-long-term-depression
#1
Łukasz Majewski, Filip Maciąg, Paweł M Boguszewski, Iga Wasilewska, Grzegorz Wiera, Tomasz Wójtowicz, Jerzy Mozrzymas, Jacek Kuznicki
STIM1 is an endoplasmic reticulum calcium sensor that is involved in several processes in neurons, including store-operated calcium entry. STIM1 also inhibits voltage-gated calcium channels, such as Cav1.2 and Cav3.1, and is thus considered a multifunctional protein. The aim of this work was to investigate the ways in which transgenic neuronal overexpression of STIM1 in FVB/NJ mice affects animal behavior and the electrophysiological properties of neurons in acute hippocampal slices. We overexpressed STIM1 from the Thy1...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27910548/high-magnetic-field-test-of-bismuth-hall-sensors-for-iter-steady-state-magnetic-diagnostic
#2
I Ďuran, S Entler, M Kohout, M Kočan, G Vayakis
Performance of bismuth Hall sensors developed for the ITER steady state magnetic diagnostic was investigated for high magnetic fields in the range ±7 T. Response of the sensors to the magnetic field was found to be nonlinear particularly within the range ±1 T. Significant contribution of the planar Hall effect to the sensors output voltage causing undesirable cross field sensitivity was identified. It was demonstrated that this effect can be minimized by the optimization of the sensor geometry and alignment with the magnetic field and by the application of "current-spinning technique...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910446/self-calibration-method-of-the-bias-of-a-space-electrostatic-accelerometer
#3
Shao-Bo Qu, Xiao-Mei Xia, Yan-Zheng Bai, Shu-Chao Wu, Ze-Bing Zhou
The high precision space electrostatic accelerometer is an instrument to measure the non-gravitational forces acting on a spacecraft. It is one of the key payloads for satellite gravity measurements and space fundamental physics experiments. The measurement error of the accelerometer directly affects the precision of gravity field recovery for the earth. This paper analyzes the sources of the bias according to the operating principle and structural constitution of the space electrostatic accelerometer. Models of bias due to the asymmetry of the displacement sensing system, including the mechanical sensor head and the capacitance sensing circuit, and the asymmetry of the feedback control actuator circuit are described separately...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27906063/characterization-of-a-multiprotein-complex-involved-in-excitation-transcription-coupling-of-skeletal-muscle
#4
Manuel Arias-Calderón, Gonzalo Almarza, Alexis Díaz-Vegas, Ariel Contreras-Ferrat, Denisse Valladares, Mariana Casas, Héctor Toledo, Enrique Jaimovich, Sonja Buvinic
BACKGROUND: Electrical activity regulates the expression of skeletal muscle genes by a process known as "excitation-transcription" (E-T) coupling. We have demonstrated that release of adenosine 5'-triphosphate (ATP) during depolarization activates membrane P2X/P2Y receptors, being the fundamental mediators between electrical stimulation, slow intracellular calcium transients, and gene expression. We propose that this signaling pathway would require the proper coordination between the voltage sensor (dihydropyridine receptor, DHPR), pannexin 1 channels (Panx1, ATP release conduit), nucleotide receptors, and other signaling molecules...
April 11, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27885269/pbs-colloidal-quantum-dot-photodetectors-operating-in-the-near-infrared
#5
Andrea De Iacovo, Carlo Venettacci, Lorenzo Colace, Leonardo Scopa, Sabrina Foglia
Colloidal quantum dots have recently attracted lot of interest in the fabrication of optoelectronic devices due to their unique optical properties and their simple and low cost fabrication. PbS nanocrystals emerged as the most advanced colloidal material for near infrared photodetectors. In this work we report on the fabrication and characterization of PbS colloidal quantum dot photoconductors. In order to make devices suitable for the monolithic integration with silicon electronics, we propose a simple and low cost process for the fabrication of photodetectors and investigate their operation at very low voltage bias...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27878194/fully-gravure-printed-complementary-carbon-nanotube-tfts-for-a-clock-signal-generator-using-an-epoxy-imine-based-cross-linker-as-an-n-dopant-and-encapsulant
#6
Donghwan Kim, Younsu Jung, Junfeng Sun, Chisun Yeom, Hyejin Park, Dae Gon Jung, Yeonkyeong Ju, Kevin Chen, Ali Javey, Gyoujin Cho
Printed p-type single walled carbon nanotube (SWCNT) based circuits exhibit high power dissipation owing to their thick printed dielectric layers (>2 μm) and long channels (>100 μm). In order to reduce the static power dissipation of printed SWCNT-base circuits while maintaining the same printing conditions and channel lengths, complementary metal-oxide-semiconductor (CMOS) based circuits are more ideal. These circuits, however, have not been successfully implemented in a scalable printing platform due to unstable threshold voltages of n-doped SWCNT based thin film transistors (TFTs)...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27875229/rapid-detection-of-protein-kinase-on-capacitive-sensing-platforms
#7
Rohit Chand, Dawoon Han, Yong-Sang Kim
In this study, we developed a capacitive sensor for the one-step and label-free detection of protein kinase A (PKA) enzyme. Metal-insulator-semiconductor (MIS) and electrolyte-insulator-semiconductor (EIS) are a simple electronic transducer, which allows efficient detection of the target analyte. For this reason, we performed a comparative sensing of PKA on the MIS and EIS capacitive sensor. The PKA-specific aptamer was used for the one-step detection. For the immobilization of thiolated aptamer, the MIS sensor contained a thin gold layer, whereas the EIS sensor had a self-aligned monolayer of gold nanoparticles...
November 18, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27874900/photosensitive-organic-field-effect-transistors-the-influence-of-znpc-morphology-and-bilayer-dielectrics-for-achieving-a-low-operating-voltage-and-low-bias-stress-effect
#8
Anamika Dey, Ashish Singh, Dipjyoti Das, Parameswar Krishnan Iyer
Photosensitive-organic field effect transistors (PS-OFETs) based on a morphology controlled zinc phthalocyanine (ZnPc) layer, with an inorganic-organic bilayer gate dielectric system, fabricated on a glass substrate showed remarkable efficiency as light sensors at various incident optical powers. The indium tin oxide (ITO) and Si/SiO2 free low-cost OFET devices show low bias stress and a reduced operating voltage with aluminum oxide and poly(methyl methacrylate) (Al2O3/PMMA) as bilayer gate dielectrics and copper (Cu) as a top contact...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27867799/the-puck-energetic-charged-particle-detector-design-heritage-and-advancements
#9
G Clark, I Cohen, J H Westlake, G B Andrews, P Brandt, R E Gold, M A Gkioulidou, R Hacala, D Haggerty, M E Hill, G C Ho, S E Jaskulek, P Kollmann, B H Mauk, R L McNutt, D G Mitchell, K S Nelson, C Paranicas, N Paschalidis, C E Schlemm
Energetic charged particle detectors characterize a portion of the plasma distribution function that plays critical roles in some physical processes, from carrying the currents in planetary ring currents to weathering the surfaces of planetary objects. For several low-resource missions in the past, the need was recognized for a low-resource but highly capable, mass-species-discriminating energetic particle sensor that could also obtain angular distributions without motors or mechanical articulation. This need led to the development of a compact Energetic Particle Detector (EPD), known as the "Puck" EPD (short for hockey puck), that is capable of determining the flux, angular distribution, and composition of incident ions between an energy range of ~10 keV to several MeV...
August 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27865041/self-powered-multimodal-temperature-and-force-sensor-based-on-a-liquid-droplet
#10
Kang Liu, Yishu Zhou, Fang Yuan, Xiaobao Mo, Peihua Yang, Qian Chen, Jia Li, Tianpeng Ding, Jun Zhou
Herein we report a self-powered multimodal temperature and force sensor based on the reverse electrowetting effect and the thermogalvanic effect in a liquid droplet. The deformation of the droplet and the temperature difference across the droplet can induce an alternating pulse voltage and a direct voltage, respectively, which is easy to separate/analyze and can be utilized to sense the external force and temperature simultaneously. In addition, an integral display system that can derive information from external temperature/force concurrently is constructed...
November 16, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27857193/a-self-regenerable-soot-sensor-with-a-proton-conductive-thin-electrolyte-and-a-nanostructured-platinum-sensing-electrode
#11
Peiling Lv, Takenori Ito, Akihide Oogushi, Kensaku Nakashima, Masahiro Nagao, Takashi Hibino
In recent years, exhaust sensors have become increasingly attractive for use in energy and environmental technologies. Important issues regarding practical applications of these sensors, especially for soot measurements, include the further development of ion-conductive electrolytes and active electrode catalysts for meeting performance and durability requirements. Herein, we design a proton conductor with a high breakdown voltage and a sensing electrode with high sensitivity to electrochemical carbon oxidation, enabling continuous soot monitoring with self-regeneration of the sensor...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846559/subthreshold-schottky-barrier-thin-film-transistors-with-ultralow-power-and-high-intrinsic-gain
#12
Sungsik Lee, Arokia Nathan
The quest for low power becomes highly compelling in newly emerging application areas related to wearable devices in the Internet of Things. Here, we report on a Schottky-barrier indium-gallium-zinc-oxide thin-film transistor operating in the deep subthreshold regime (i.e., near the OFF state) at low supply voltages (<1 volt) and ultralow power (<1 nanowatt). By using a Schottky-barrier at the source and drain contacts, the current-voltage characteristics of the transistor were virtually channel-length independent with an infinite output resistance...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27843395/computational-models-for-the-determination-of-depth-dependent-mechanical-properties-of-skin-with-a-soft-flexible-measurement-device
#13
Jianghong Yuan, Canan Dagdeviren, Yan Shi, Yinji Ma, Xue Feng, John A Rogers, Yonggang Huang
Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane)...
October 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27834902/mechanical-fault-diagnosis-of-high-voltage-circuit-breakers-based-on-variational-mode-decomposition-and-multi-layer-classifier
#14
Nantian Huang, Huaijin Chen, Guowei Cai, Lihua Fang, Yuqiang Wang
Mechanical fault diagnosis of high-voltage circuit breakers (HVCBs) based on vibration signal analysis is one of the most significant issues in improving the reliability and reducing the outage cost for power systems. The limitation of training samples and types of machine faults in HVCBs causes the existing mechanical fault diagnostic methods to recognize new types of machine faults easily without training samples as either a normal condition or a wrong fault type. A new mechanical fault diagnosis method for HVCBs based on variational mode decomposition (VMD) and multi-layer classifier (MLC) is proposed to improve the accuracy of fault diagnosis...
November 10, 2016: Sensors
https://www.readbyqxmd.com/read/27834846/organic-vapour-sensing-properties-of-area-ordered-and-size-controlled-silicon-nanopillar
#15
Wei Li, Zhilin Feng, Enwen Dai, Jie Xu, Gang Bai
Here, a silicon nanopillar array (Si-NPA) was fabricated. It was studied as a room-temperature organic vapour sensor, and the ethanol and acetone gas sensing properties were detected with I-V curves. I-V curves show that these Si-NPA gas sensors are sensitive to ethanol and acetone organic vapours. The turn-on threshold voltage is about 0.5 V and the operating voltage is 3 V. With 1% ethanol gas vapour, the response time is 5 s, and the recovery time is 15 s. Furthermore, an evaluation of the gas sensor stability for Si-NPA was performed...
November 9, 2016: Sensors
https://www.readbyqxmd.com/read/27826505/ammonia-gas-sensors-based-on-in2o3-pani-hetero-nanofibers-operating-at-room-temperature
#16
Qingxin Nie, Zengyuan Pang, Hangyi Lu, Yibing Cai, Qufu Wei
Indium nitrate/polyvinyl pyrrolidone (In(NO3)3/PVP) composite nanofibers were synthesized via electrospinning, and then hollow structure indium oxide (In2O3) nanofibers were obtained through calcination with PVP as template material. In situ polymerization was used to prepare indium oxide/polyaniline (In2O3/PANI) composite nanofibers with different mass ratios of In2O3 to aniline. The structure and morphology of In(NO3)3/PVP, In2O3/PANI composite nanofibers and pure PANI were investigated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and current-voltage (I-V) measurements...
2016: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/27826230/ampa-receptors-are-involved-in-store-operated-calcium-entry-and-interact-with-stim-proteins-in-rat-primary-cortical-neurons
#17
Joanna Gruszczynska-Biegala, Maria Sladowska, Jacek Kuznicki
The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca(2+)) after their release into the cytoplasm. Interactions between (ER)-located Ca(2+) sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca(2+) channel-forming protein (Orai1) underlie SOCE and are well described in non-excitable cells. In neurons, however, SOCE appears to be more complex because of the importance of Ca(2+) influx via voltage-gated or ionotropic receptor-operated Ca(2+) channels...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27819327/structure-and-function-of-fs50-a-salivary-protein-from-the-flea-xenopsylla-cheopis-that-blocks-the-sodium-channel-nav1-5
#18
Xueqing Xu, Bei Zhang, Shilong Yang, Su An, José M C Ribeiro, John F Andersen
Naturally occurring toxins have been invaluable tools for the study of structural and functional relationships of voltage-gated sodium channels (VGSC). Few studies have been made of potential channel-modulating substances from blood-feeding arthropods. He we describe the characterization FS50, a salivary protein from the flea, Xenopsylla cheopis, that exhibits an inhibitory activity against the NaV1.5 channel with an IC50 of 1.58 μM. The pore-blocking mechanism of this toxin is evident from the kinetics of activation and inactivation suggesting that FS50 does not interfere with the voltage sensor of NaV1...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818003/commandeering-channel-voltage-sensors-for-secretion-cell-turgor-and-volume-control
#19
REVIEW
Rucha Karnik, Sakharam Waghmare, Ben Zhang, Emily Larson, Cécile Lefoulon, Wendy Gonzalez, Michael R Blatt
Control of cell volume and osmolarity is central to cellular homeostasis in all eukaryotes. It lies at the heart of the century-old problem of how plants regulate turgor, mineral and water transport. Plants use strongly electrogenic H(+)-ATPases, and the substantial membrane voltages they foster, to drive solute accumulation and generate turgor pressure for cell expansion. Vesicle traffic adds membrane surface and contributes to wall remodelling as the cell grows. Although a balance between vesicle traffic and ion transport is essential for cell turgor and volume control, the mechanisms coordinating these processes have remained obscure...
October 28, 2016: Trends in Plant Science
https://www.readbyqxmd.com/read/27810832/structural-solution-to-enhance-the-sensitivity-of-a-self-powered-pressure-sensor-for-an-artificial-tactile-system
#20
Minkyung Sim, Kyunghwa Lee, Yeri Jeong, Jeonghee Shin, Jung Inn Sohn, Seung Nam Cha, Jae Eun Jang
Structural design factors of sensor units have been studied in order to enhance the sensitivity of pressure sensors based on utilizing a piezoelectric material for an artificial tactile sensor. In this study, we have primarily demonstrated the effect of a square pattern array design in a pressure sensor using ZnO nanowires. Nanowires grown on the edge of cells can be bent easily because of growth direction, density control, and buckling effect. Since smaller square pattern arrays induce a higher circumference to cell area ratio, if one sensor unit consists of many micro-level square pattern arrays, the design enhances the piezoelectric efficiency and the sensitivity...
October 27, 2016: IEEE Transactions on Nanobioscience
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