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https://www.readbyqxmd.com/read/29475069/in-vitro-model-to-study-cocaine-and-its-contaminants
#1
Aline Steinmetz, Luiza Steffens, Ana Moira Morás, Flávia Prezzi, Elizandra Braganhol, Jenifer Saffi, Rafael Scorsatto Ortiz, Helena M T Barros, Dinara Jaqueline Moura
Cocaine is one of the most popular illicit drug worldwide. Due its great addictive potential, which leads to euphoria and hyperactivity, it is considered a public health concern. At the central nervous system, the drug acts inhibiting catecholamine re-uptake. It is now known that in addition to the toxicity of the drug itself, the contaminants present in the street drug have raised concern about the harmful effects on health. Toxicological in vivo and in vitro studies have demonstrated the toxic effects of cocaine correlated with the generation of reactive oxygen species (ROS), which in turn lead to oxidative damage to the cells...
February 20, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29473967/importance-of-wide-re-resection-in-adult-spermatic-cord-sarcomas-report-on-oncologic-outcomes-at-a-single-institution
#2
Katie S Murray, Emily A Vertosick, Massimiliano Spaliviero, Joseph W Mashni, Daniel D Sjoberg, Kaled M Alektiar, Harry W Herr, Paul Russo, Jonathan A Coleman
BACKGROUND AND OBJECTIVES: We evaluated the effect of re-resection with wide margins (undertaken because initial resection performed elsewhere was incomplete) on survival in patients with spermatic cord sarcoma (SCS). METHODS: After excluding those with metastatic disease and those not undergoing surgical intervention, the records of 72 consecutive patients treated for SCS between 1981 and 2011 at Memorial Sloan Kettering Cancer Center were reviewed. Recurrence-free survival (RFS) and cancer-specific survival were calculated using the Kaplan-Meier method for comparing between the 48 patients who underwent wide re-resection (WRR) within 5 months of diagnosis and the 24 who did not...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473117/relationship-among-symptom-clusters-quality-of-life-and-treatment-specific-optimism-in-patients-with-cancer
#3
Martin Matzka, Sabine Köck-Hódi, Patrick Jahn, Hanna Mayer
PURPOSE: There is increasing evidence that disease and therapy-related symptoms frequently co-occur in so-called symptom clusters (SCs), which may significantly impair quality of life in patients with cancer. Although psychosocial resources may play pivotal roles in maintaining or improving quality of life, they have been neglected in SC research. Therefore, we aim to identify SCs and their relative impact on quality of life when psychosocial resources are accounted for. METHODS: Patients with cancer (n = 304) undergoing chemotherapy or chemo-radiation therapy participated in a cross-sectional survey consisting of measures assessing symptoms, quality of life, resilience, treatment-specific optimism (TSO), and social support...
February 23, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29471831/prediction-of-suboptimal-cytoreductive-surgery-in-patients-with-advanced-ovarian-cancer-based-on-preoperative-and-intraoperative-determination-of-the-peritoneal-carcinomatosis-index
#4
Antoni Llueca, Anna Serra, Isabel Rivadulla, Luis Gomez, Javier Escrig
BACKGROUND: The peritoneal carcinomatosis index (PCI) can be used to quantify the tumor burden in patients with advanced ovarian cancer. The aim of the present study was to establish a predictive model for suboptimal cytoreductive surgery (SCS) (residual tumor of > 1 cm) using preoperative and intraoperative determination of the PCI. METHODS: In total, 110 consecutive patients treated for advanced ovarian cancer during a 4-year period in our institution were assessed...
February 23, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29471202/conductive-micropatterned-polyurethane-films-as-tissue-engineering-scaffolds-for-schwann-cells-and-pc12-cells
#5
Yaobin Wu, Ling Wang, Tianli Hu, Peter X Ma, Baolin Guo
Controlling cellular alignment and elongation has been demonstrated as an important parameter for developing nerve tissue engineering scaffolds. Many approaches have been developed to guide cellular orientation for nerve regeneration such as micropatterning techniques. However, most of materials used for developing micropatterning scaffolds lack of bioactivity and biofunctionability. Here we present a functional conductive micropatterned scaffold based on bioactive conductive biodegradable polyurethane prepared using a micro-molding technique...
February 13, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29471033/inhibition-of-lymphocyte-proliferation-an-ability-shared-by-murine-mesenchymal-stem-cells-dermal-fibroblasts-and-chondrocytes
#6
Shang Zhang, Haitao Wu, Changlin Liu
It has been demonstrated that mesenchymal stem cells (MSCs) have potent immunosuppressive capacities. But it is controversial whether differentiated mature stromal cells (SCs) share the immunosuppressive capacities. A previous study examined the ability of SCs from different human tissue sites to inhibit the proliferation of lymphocytes. The results are all positive but the mechanism isn't clear, and few mouse data have been published on this topic. Using an efficient mixed cell culture assay, our in vitro data show that the anti-proliferative ability of murine MSCs on lymphocytes is shared by mature murine SCs, i...
February 19, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29468441/a-new-minimally-invasive-technique-for-lead-revision-of-perc-paddle-leads
#7
Olivier De Coster, Patrice Forget, Maarten Moens, Milica Matic, Lucie Choustoulakis, Jan Poelaert
To report on a less-invasive technique for replacing a broken lead in a spinal cord stimulation (SCS) device that makes use of St. Jude Medical's "Epiducer" device. A 53-year-old woman suffered a loss of stimulation on her internal pulse generator (IPG), which was found to have a broken lead. The broken lead was withdrawn using the Epiducer device with minimal invasiveness and without pain. A new lead was put in place, and successful stimulation using the IPG resumed. Follow-up 3 weeks later showed a well-functioning SCS system...
February 21, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29464750/inhibition-of-adam10-in-satellite-cells-accelerates-muscle-regeneration-following-muscle-injury
#8
Sakiko Mizuno, Masaki Yoda, Masayuki Shimoda, Kazuhiro Chiba, Masaya Nakamura, Keisuke Horiuchi
Muscle injury is one of the most common orthopedic and sports disorders. For severe cases, surgical repair may be indicated; however, other than immobilization and the administration of anti-inflammatory drugs there is currently no effective conservative treatment for this condition. Satellite cells (SCs) are muscle-specific stem cells and are indispensable for muscle regeneration after muscle injury. SCs are activated upon muscle injury to proliferate and differentiate into myoblasts, which subsequently fuse into myofibers and regenerate the damaged muscle...
February 21, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29463475/preliminary-validation-of-a-german-version-of-the-sexual-complaints-screener-for-women-in-a-female-population-sample
#9
Andrea Burri, Hartmut Porst
BACKGROUND: To date, neither the original English nor any of the translated versions of the Sexual Complaints Screener for Women (SCS-W) have been tested for their psychometric properties. AIM: To evaluate the validity and utility of the German version of the SCS-W by assessing content, convergent, and discriminant validity. METHODS: A population sample of 309 women (mean age = 26.9 years) completed the online survey and had matching data available on the SCS-W and the Female Sexual Function Index (FSFI)...
February 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29462706/biomaterials-cues-to-direct-a-pro-regenerative-phenotype-in-macrophages-and-schwann-cells
#10
Melissa R Wrobel, Harini G Sundararaghavan
Following peripheral nerve injury (PNI), inflammatory cues impede repair. We have previously demonstrated that spinal cord matrix (SCM) proteins and hyaluronic acid (HA) nanofibers mitigate chondroitin sulfate proteoglycan (CSPG) inhibition and promote growth in peripheral neurons. In this study, we evaluated the effects of a characteristic CSPG, Chondroitin sulfate A (CSA), SCM, and HA fibers on macrophages and Schwann Cells (SCs). We hypothesized that our cues would accelerate the macrophages return to rest following classical activation (M1/pro-inflammatory) with lipopolysaccharide (LPS; 1μg/mL) and would accelerate the transformation of SCs from an immature state following injury to a mature/pro-myelinating phenotype...
February 17, 2018: Neuroscience
https://www.readbyqxmd.com/read/29462593/carboxymethylated-chitosan-protects-schwann-cells-against-hydrogen-peroxide-induced-apoptosis-by-inhibiting-oxidative-stress-and-mitochondria-dependent-pathway
#11
Bin He, Fei Wu, Li Fan, Xiao-Hai Li, Yang Liu, Ya-Jing Liu, Wan-Jun Ding, Ming Deng, Yan Zhou
Carboxymethylated chitosan (CMCS) has many beneficial effects, including anti-oxidant and anti-apoptotic actions. However, the mechanisms by which CMCS protect against oxidative stress induced damage to Schwann cells (SCs) remains unclear. The present study aimed to investigate the mechanism by which CMCS protects SCs against hydrogen peroxide (H2 O2 ) induced damage. H2 O2 was used to establish a model of oxidative stress injury in SCs to mimic the development of nerve injury in vitro. Different concentrations (50, 100 and 200µg/ml) of CMCS were added to test whether CMCS was capable of protecting SCs from H2 O2 induced damage...
February 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29462272/reasons-for-conversion-and-adverse-intraoperative-events-in-endoscopic-port-access%C3%A2-atrioventricular-valve-surgery-and-minimally-invasive-aortic-valve-surgery
#12
Johan van der Merwe, Frank Van Praet, Bernard Stockman, Ivan Degrieck, Yvette Vermeulen, Filip Casselman
OBJECTIVES: This study reports the factors that contribute to sternotomy conversions (SCs) and adverse intraoperative events in minimally invasive aortic valve surgery (MI-AVS) and minimally invasive Endoscopic Port Access™ atrioventricular valve surgery (MI-PAS). METHODS: In total, 3780 consecutive patients with either aortic valve disease or atrioventricular valve disease underwent minimally invasive valve surgery (MIVS) at our institution between 1 February 1997 and 31 March 2016...
February 14, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29459438/non-cell-autonomous-function-of-dr6-in-schwann-cell-proliferation
#13
Alessio Colombo, Hung-En Hsia, Mengzhe Wang, Peer-Hendrik Kuhn, Monika S Brill, Paolo Canevazzi, Regina Feederle, Carla Taveggia, Thomas Misgeld, Stefan F Lichtenthaler
Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell-autonomous manner in different cell types. Here, we report an additional non-cell-autonomous function for DR6 in the peripheral nervous system (PNS). DR6-knockout (DR6 KO) mice showed precocious myelination in the PNS Using an in vitro myelination assay, we demonstrate that neuronal DR6 acts in trans on Schwann cells (SCs) and reduces SC proliferation and myelination independently of its cytoplasmic death domain...
February 19, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29456888/an-observational-study-on-risk-of-secondary-cancers-in-chronic-myeloid-leukemia-patients-in-the-tki-era-in-the-united-states
#14
Vivek Kumar, Mohit Garg, Neha Chaudhary, Abhinav Binod Chandra
Introduction: The treatment with tyrosine kinase inhibitors (TKIs) has drastically improved the outcome of chronic myeloid leukemia (CML) patients. This study was conducted to examine the risk of secondary cancers (SCs) in the CML patients who were diagnosed and treated in the TKI era in the United States. Methods: The surveillance epidemiology and end results (SEER) database was used to identify CML patients who were diagnosed and received treatment during January 2002-December 2014...
2018: PeerJ
https://www.readbyqxmd.com/read/29454661/rethinking-phagocytes-clues-from-the-retina-and-testes
#15
REVIEW
Kristen K Penberthy, Jeffrey J Lysiak, Kodi S Ravichandran
Specialized phagocytes are a newly appreciated classification of phagocyte that currently encompasses Sertoli cells (SCs) of the testes and the retinal pigment epithelial cells (RPE) of the retina. While these cells support very different tissues, they have a striking degree of similarity both as phagocytes and in ways that go beyond cell clearance. The clearance of apoptotic germ cells, cell debris, and used photoreceptor outer segments are critical functions of these cells, and the unique nature of their clearance events make specialized phagocytes uniquely suited for studying the larger implications of cell clearance in vivo...
February 14, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29453572/proteome-profiling-of-sertoli-cells-using-a-gelc-ms-ms-strategy
#16
Rita Ferreira, Fábio Trindade, Rui Vitorino
Proteomics is a technology that allows to decipher the molecular networks involved in the regulation of biological processes such as spermatogenesis. Sertoli cells (SCs) are key players in the paracrine control of this process. Envisioning to increase the knowledge on the molecular networks harbored in SCs, we propose a methodology based on GeLC-MS/MS for the characterization of these cells' proteome. Proteins are separated by SDS-PAGE hyphenated to HPLC and identified by mass spectrometry. The integration of data with bioinformatics tools such as ClueGO + CluePedia from Cytoscape allows the identification of the biological pathways more prevalent in SCs, and that might be modulated by pathophysiological conditions...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29453568/a-method-for-in-vivo-induction-and-ultrastructural-detection-of-mitophagy-in-sertoli-cells
#17
Nabil Eid, Yuko Ito, Akio Horibe, Hitomi Hamaoka, Yoichi Kondo
An emerging body of evidences based on in vitro studies indicate that mitophagy (selective autophagic clearance of damaged mitochondria) is a prosurvival mechanism, specifically under exposure to various stressors. Sertoli cells (SCs) play essential roles in maintenance of spermatogenesis via paracrine interactions with germ cells and other somatic cells in the testis; however, studies investigating mitophagy in SCs are still very few. In this chapter, we give a brief review of mechanisms and detection methods of mitophagy in SCs based on our recent publications on animal models of ethanol toxicity and current literature...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29446818/heart-involvement-in-systemic-sclerosis
#18
Ihsen Zairi, Lilia Baili, Khadija Mzoughi, Manel Dridi, Zouhaier Jnifene, Fatma Boussema
INTRODUCTION: Primary and secondary heart involvement in systemic sclerosis are important mortality predictors. Aim of this study was to investigate by standard echocardiography associated to pulsed-tissue Doppler imaging, six-minute walk test (6MWT) and BNP level cardiac manifestation in 30 patients with ScS and to establish a strategy to detect and to evaluate this complication. METHODS: This was a cross-sectional study conducted over a period of 16 months: a total of 30 consecutive patients with ScS diagnosed as proposed by the American college of Rheumatology and the European League Against Rheumatism 2013 and who were hospitalized in Internal Medicine department of Habib Thameur hospital underwent cardiac assessment...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29446742/development-of-an-in-vitro-drug-delivery-efficiency-test-for-a-pulmonary-toxicokinetic-pig-study
#19
Nadine Schaefer, Ann-Katrin Kroll, Matthias W Laschke, Michael D Menger, Hans H Maurer, Markus R Meyer, Peter H Schmidt
BACKGROUND: Since their appearance on the drugs of abuse market, synthetic cannabinoids (SCs) are gaining increasing toxicological relevance. They are consumed without knowledge of their toxicokinetic (TK) and toxicodynamic properties and human studies are not allowed due to ethical reasons. A controlled animal TK study following nebulization of 4-ethylnaphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-210), 2-(4-methoxyphenyl)-1-(1-pentyl-indole-3-yl)methanone (RCS-4) as well as Δ9-tetrahydrocannabinol (THC) to pigs should be helpful for better interpretation of analytical results in cases of misuse or poisoning...
February 14, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29446524/impact-of-blood-flow-restricted-bodyweight-exercise-on-skeletal-muscle-adaptations
#20
J E Jakobsgaard, M Christiansen, P Sieljacks, J Wang, T Groennebaek, F de Paoli, K Vissing
This study ascertains the ability of bodyweight blood flow-restricted (BFR) exercise training to promote skeletal muscle adaptations of significance for muscle accretion and metabolism. Six healthy young individuals (three males and three females) performed six weeks of bodyweight BFR training. Each session consisted of five sets of sit-to-stand BFR exercise to volitional failure with 30-second inter-set recovery. Prior to, and at least 72 h after training, muscle biopsies were taken from m. vastus lateralis to assess changes in fibre type-specific cross-sectional area (CSA), satellite cell (SC) and myonuclei content and capillarization, as well as mitochondrial protein expression...
February 15, 2018: Clinical Physiology and Functional Imaging
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