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https://www.readbyqxmd.com/read/29031103/kaposi-s-sarcoma-herpesvirus-induced-endothelial-cell-reprogramming-supports-viral-persistence-and-contributes-to-kaposi-s-sarcoma-tumorigenesis
#1
REVIEW
Silvia Gramolelli, Päivi M Ojala
Kaposi's sarcoma (KS) is an endothelial tumor causally linked to Kaposi's sarcoma herpesvirus (KSHV) infection. At early stages of KS, inflammation and aberrant neoangiogenesis are predominant, while at late stages the disease is characterized by the proliferation of KSHV-infected spindle cells (SC). Since KSHV infection modifies the endothelial cell (EC) identity, the origin of SCs remains elusive. Yet, pieces of evidence indicate the lymphatic origin. KSHV-infected ECs display increased proliferative, angiogenic and migratory capacities which account for KS oncogenesis...
October 11, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29030955/vertically-aligned-co9s8-nanotube-arrays-onto-graphene-papers-as-high-performance-flexible-electrodes-for-supercapacitors
#2
Xifei Li, Dongbin Xiong, Zhimin Bai, Jianwei Li, Yan Han, Dejun Li
The paper-like electrodes are emerging as a new category of advanced electrodes for flexible supercapacitors (SCs). Graphene, a promising two-dimensional material with high conductivity, can be easily processed into papers. Here, we report a rational design of flexible architecture with Co9S8 nanotube arrays (NAs) grown onto graphene papers (GPs) via a facile two-step hydrothermal method. When employed as a novel flexible free-standing electrode for SCs, the proposed architectured Co9S8/GPs exhibits superior electrochemical performance with ultrahigh capacitance and outstanding rate capability (469 F g-1 at 10 A g-1)...
October 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29030424/stable-coronary-syndromes-pathophysiology-diagnostic-advances-and-therapeutic-need
#3
REVIEW
Thomas J Ford, David Corcoran, Colin Berry
The diagnostic management of patients with angina pectoris typically centres on the detection of obstructive epicardial CAD, which aligns with evidence-based treatment options that include medical therapy and myocardial revascularisation. This clinical paradigm fails to account for the considerable proportion (approximately one-third) of patients with angina in whom obstructive CAD is excluded. This common scenario presents a diagnostic conundrum whereby angina occurs but there is no obstructive CAD (ischaemia and no obstructive coronary artery disease-INOCA)...
October 13, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29024125/new-insights-into-the-operating-voltage-of-aqueous-supercapacitors
#4
Minghao Yu, Yongzhuang Lu, Haibing Zheng, Xihong Lu
The main limitation of aqueous supercapacitors (SCs) lies in their narrow operating voltages, especially when compared with organic SCs. Fundamental understanding of factors relevant to the operating voltage helps providing guidance for the assembly of high-voltage aqueous SCs. In this regard, this concept analyzes the deciding factors for the operating voltage of aqueous SCs. Strategies applied to expand the operating voltage are summarized and discussed from the aspects of electrolyte, electrode and asymmetric structure...
October 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29017400/minimally-invasive-method-to-activate-the-expiratory-muscles-to-restore-cough
#5
Anthony F DiMarco, Robert T Geertman, Kutaiba Tabbaa, Rebecca R Polito, Krzysztof E Kowalski
CONTEXT: Spinal cord stimulation (SCS) via disc electrodes surgically placed via laminotomy incisions has been shown to restore an effective cough in subjects with spinal cord injury (SCI). The purpose of this study was to evaluate a new method of expiratory muscle activation utilizing spinal cord wire leads, which can be implanted with minimally invasive techniques. METHODS: In a subject with SCI, parallel wire leads with two electrode contacts were inserted percutaneously through a needle, advanced to the T9, T11 spinal levels and connected to an implanted radiofrequency receiver...
October 11, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29017069/comprehensive-self-control-training-benefits-depressed-college-students-a-six-month-randomized-controlled-intervention-trial
#6
Xueling Yang, Jiubo Zhao, Yu Chen, Simeng Zu, Jingbo Zhao
BACKGROUND: Depressive disorder was associated with dysfunctional self-regulation. The current study attempted to design and test a comprehensive self-control training (CSCT) program with an overall emphasis on behaviral activation in depressed Chinese college students. METHODS: Participants included 74 students who had diagnosed with major depression, they were randomly assigned to one of the two groups: intervention group (n=37), and control group (n=37). The intervention participants received an eight-week CSCT and four-month follow-up consolidation program, as compared to the control group who received only pre-post-and-follow-up measurements...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29016994/neuromodulation-in-postherpetic-neuralgia-case-reports-and-review-of-the-literature
#7
Svetlana Kurklinsky, Scott C Palmer, Mack J Arroliga, Salim M Ghazi
Objective: Postherpetic neuralgia (PHN) is common in the United States. Current treatment options for PHN are fairly limited. Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are considered mostly experimental and still rarely performed in patients with PHN. Design: Two case reports and a review of the literature. Setting: Tertiary academic medical center. Methods: 1) Pubmed, Ovid, and EBMR databases were searched for all reports that had the following key words: postherpetic neuralgia, spinal cord stimulation, and peripheral nerve stimulation...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28994838/dft-investigation-of-the-interaction-between-single-walled-carbon-nanotubes-and-fluorene-based-conjugated-oligomers
#8
Mohammad Zahidul H Khan, Ahmad I Alrawashdeh, Suad Aljohani, Yuming Zhao, Jolanta B Lagowski
π-Conjugated oligomers with relatively short molecular backbones can be used effectively in dispersion of carbon nanotubes (CNTs). In this paper, we present a systematic study on interactions between diphenylene-fluorene oligomers (DPFs) and single-walled CNTs (SWCNTs) using density functional theory (DFT) calculations. Four DFT methods are used in this work: the long range (LR)-corrected CAM-B3LYP, the dispersion (D)-corrected B97D, the LR- and D-corrected wB97XD, and the hybrid B3LYP. The DPFs examined in this study contain different functional groups attached to the π-conjugated backbone, including two different end groups, carboxaldehyde (ALD) and dithiafulvenyl (DTF), and three different side chains (SCs), C8H17, OC10H21, and SC10H21...
October 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28994835/attractive-phhp-interactions-revealed-by-state-of-the-art-ab-initio-calculations
#9
Sirous Yourdkhani, Mirosław Jabłoński, Jorge Echeverría
We report in this work a combined structural and state-of-the-art computational study of homopolar P-HH-P intermolecular contacts. Database surveys have shown the abundance of such surprisingly unexplored contacts, which are usually accompanied by other weak interactions in the solid state. By means of a detailed theoretical study utilizing SAPT(DFT), MP2, SCS-MP2, MP2C and CCSD(T) methods and both aug-cc-pVXZ and aug-cc-pCVXZ (X = D, T, Q, 5) basis sets as well as extrapolation to the CBS limit, we have shown that P-HH-P contacts are indeed attractive and considerably strong...
October 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28994759/a-novel-method-super-selective-adrenal-venous-sampling
#10
Kohzoh Makita, Koshiro Nishimoto, Kanako Kiriyama-Kitamoto, Shigehiro Karashima, Tsugio Seki, Masanori Yasuda, Seishi Matsui, Masao Omura, Tetsuo Nishikawa
Primary aldosteronism (PA) and subclinical Cushing's syndrome (SCS) are conditions in which the adrenal glands autonomously produce excessive amounts of aldosterone and cortisol, respectively. The conventional adrenal venous sampling (cAVS) method collects blood samples from both adrenal central veins and is useful for identifying the laterality of excess hormone production in a unilateral lesion(s), as documented in PA cases. In cAVS, plasma cortisol concentrations (PCCs) are used to normalize plasma aldosterone concentrations (PACs)...
September 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28993852/the-effects-of-the-obesogen-tributyltin-on-the-metabolism-of-sertoli-cells-cultured-ex-vivo
#11
Ana M Cardoso, Marco G Alves, Ana C Sousa, Ivana Jarak, Rui A Carvalho, Pedro F Oliveira, José E Cavaco, Luís Rato
Human exposure to environmental contaminants is widespread. Some of these contaminants have the ability to interfere with adipogenesis, being thus considered as obesogens. Recently, obesogens have been singled out as a cause of male infertility. Sertoli cells (SCs) are essential for male fertility and their metabolic performance, especially glucose metabolism, is under a tight endocrine control, being essential for the success of spermatogenesis. Herein, we studied the impact of the model obesogen tributyltin in the metabolic profile of SCs...
October 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28993773/targeting-malignant-brain-tumors-with-antibodies
#12
REVIEW
Rok Razpotnik, Neža Novak, Vladka Čurin Šerbec, Uros Rajcevic
Antibodies have been shown to be a potent therapeutic tool. However, their use for targeting brain diseases, including neurodegenerative diseases and brain cancers, has been limited, particularly because the blood-brain barrier (BBB) makes brain tissue hard to access by conventional antibody-targeting strategies. In this review, we summarize new antibody therapeutic approaches to target brain tumors, especially malignant gliomas, as well as their potential drawbacks. Many different brain delivery platforms for antibodies have been studied such as liposomes, nanoparticle-based systems, cell-penetrating peptides (CPPs), and cell-based approaches...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28993509/a-large-scale-rnai-screen-identifies-sgk1-as-a-key-survival-kinase-for-gbm-stem-cells
#13
Shreya Kulkarni, Surbhi Goel, Sejuti Sengupta, Brent H Cochran
Glioblastoma Multiforme (GBM) is the most common type of primary malignant brain cancer and has a very poor prognosis. A subpopulation of cells known as GBM stem-like cells (GBM-SCs) have the capacity to initiate and sustain tumor growth and possess molecular characteristics similar to the parental tumor. GBM-SCs are known to be enriched in hypoxic niches and may contribute to therapeutic resistance. Therefore, to identify genetic determinants important for the proliferation and survival of GBM stem cells, an unbiased pooled shRNA screen of 10,000 genes was conducted under normoxic as well as hypoxic conditions...
October 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28993290/spinal-cord-injury-associated-with-cervical-spinal-canal-stenosis-outcomes-and-prognostic-factors
#14
Y Ronzi, B Perrouin-Verbe, O Hamel, R Gross
OBJECTIVES: To specify outcomes and identify prognostic factors of neurologic and functional recovery in patients with an acute traumatic spinal cord injury (SCI) associated with cervical spinal canal stenosis (SCS), without spinal instability. METHODS: A retrospective study was conducted using data from a Regional Department for SCI rehabilitation in France. A description of the population characteristics, clinical data and neurological and functional outcomes of all patients treated for acute SCI due to cervical trauma associated with SCS was performed...
October 6, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28993093/hypersexual-disorder-according-to-the-hypersexual-disorder-screening-inventory-in-help-seeking-swedish-men-and-women-with-self-identified-hypersexual-behavior
#15
Katarina Görts Öberg, Jonas Hallberg, Viktor Kaldo, Cecilia Dhejne, Stefan Arver
INTRODUCTION: The Hypersexual Disorder Screening Inventory (HDSI) was developed by the American Psychiatric Association for clinical screening of hypersexual disorder (HD). AIMS: To examine the distribution of the proposed diagnostic entity HD according to the HDSI in a sample of men and women seeking help for problematic hypersexuality and evaluate some psychometric properties. METHODS: Data on sociodemographics, the HDSI, the Sexual Compulsivity Scale (SCS), and the Cognitive and Behavioral Outcomes of Sexual Behavior were collected online from 16 women and 64 men who self-identified as hypersexual...
October 6, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28992356/uplc-hr-ms-ms-based-determination-study-on-the-metabolism-of-four-synthetic-cannabinoids-adb-fubica-ab-fubica-ab-bica-and-adb-bica-by-human-liver-microsomes
#16
Jing Li, Cuimei Liu, Tao Li, Zhendong Hua
Since 2012, several cannabimimetic indazole and indole derivatives with valine amino acid amide residue have emerged in the illicit drug market, and gradually replaced the old generations of synthetic cannabinoids (SCs) with naphthyl or adamantine groups. Among them, ADB-FUBICA, AB-FUBICA, AB-BICA and ADB-BICA were detected in China recently, but unfortunately no information about their in vitro human metabolism is available for now. Therefore, biomonitoring studies to screen their consumption lack any information about the potential biomarkers (e...
October 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28987587/relationship-between-intramammary-infection-prevalence-and-somatic-cell-score-in-commercial-dairy-herds
#17
G E Shook, R L Bamber Kirk, F L Welcome, Y H Schukken, P L Ruegg
We examined consistency of the relationship between intramammary infection (IMI) and somatic cell score (SCS) across several classes of cow, herd, and sampling time variables. Microbial cultures of composite milk samples were performed by New York Quality Milk Production Services from 1992 to 2004. SCS was from the most recent Dairy Herd Improvement test before IMI sampling. Records were analyzed from 79,308 cows in 1,124 commercial dairy herds representing a broad range of production systems. Three binary dependent variables were presence or absence of contagious IMI, environmental IMI, and all IMI...
October 4, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28986737/assessing-the-degree-of-stratification-between-closely-related-holstein-friesian-populations
#18
Joanna Szyda, Tomasz Suchocki, Saber Qanbari, Zengting Liu, Henner Simianer
Genomic information is an important part of the routine evaluation of dairy cattle and provides the wide availability of animals genotyped using single nucleotide polymorphism (SNP) microarrays. We analyzed 2243 Polish and 2294 German Holstein-Friesian bulls genotyped using the Illumina BovineSNP50 BeadChip. For each bull, estimated breeding values (EBVs) calculated from national routine genetic evaluation were available for production traits and for somatic cell score (SCS). Separately for each population, we estimated SNP haplotypes, pairwise linkage disequilibrium (LD), and SNP effects...
October 6, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28986586/statistical-analysis-and-a-case-study-of-tropical-cyclones-that-trigger-the-onset-of-the-south-china-sea-summer-monsoon
#19
Jingliang Huangfu, Ronghui Huang, Wen Chen
This paper addresses whether a tropical cyclone can trigger the onset of the South China Sea (SCS) summer monsoon (SM). We conducted a statistical analysis of tropical cyclones (TCs) generated over the western North Pacific (WNP) between late-April and May. The results showed that there were cases in which TCs were generated before the onset of the SCSSM, accounting for 43.2% of the TCs generated during this season. This study examined a representative case, Super Typhoon Chanchu (0601), which was determined to be influential in the onset of the SCSSM...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982707/post-injury-induction-of-activated-erbb2-selectively-hyperactivates-denervated-schwann-cells-and-promotes-robust-dorsal-root-axon-regeneration
#20
Seung Baek Han, Hyukmin Kim, Hyunkyoung Lee, Matthew Grove, George M Smith, Young-Jin Son
Following nerve injury, denervated Schwann cells (SCs) convert to repair SCs, which enable regeneration of peripheral axons. However, the repair capacity of SCs and the regenerative capacity of peripheral axons are limited. In the present studies we examined a potential therapeutic strategy to enhance the repair capacity of SCs, and tested its efficacy in enhancing regeneration of dorsal root (DR) axons, whose regenerative capacity is particularly weak. We used male and female mice of a doxycycline-inducible transgenic line to induce expression of constitutively active ErbB2 (caErbB2) selectively in SCs after DR crush or transection...
October 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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