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A Lind, P Emami, M Sjödin, L Katila, M Wetterhall, T Gordh, K Kultima
Aims The aim of this study was to uncover possible proteins involved in the mechanism for neuropathic spinal cord stimulation (SCS) pain relief in humans. Methods Using two different proteomic protocols we compared the protein concentration in cerebrospinal fluid (CSF) from 14 SCS responsive neuropathic pain patients using a shotgun proteomic approach. The comparison was made between samples from the same individual taken when the stimulator had been off for 48 h, and after the stimulator had been used as normal for three weeks...
December 29, 2017: Scandinavian Journal of Pain
A Jonsson, A-L Lind, M Hallberg, F Nyberg, T Gordh
Aims Neuropathic pain is a complex and painful condition, which is difficult to treat and causes a lot of suffering. The substance P (SP) system is well known to be involved in nociceptive signaling and it has previously been shown that the cerebrospinal fluid (CSF) level of SP is decreased in neuropathic pain. In this study we analyzed CSF from chronic neuropathic pain patients for the levels of SP1-7, an N-terminal fragment of SP with the ability to alleviate thermal as well as mechanical hypersensitivity in different animal models of chronic neuropathic pain, e...
December 29, 2017: Scandinavian Journal of Pain
Lubertus Bijlsma, Rubén Gil-Solsona, Félix Hernández, Juan Vicente Sancho
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, creates a scenario with constantly moving analytical targets, making their monitoring and identification challenging. The development of fast screening strategies for SCs, not directly focused on their chemical structure, as an alternative to the commonly applied target acquisition methods, would be highly appreciated in forensic and public health laboratories...
June 16, 2018: Analytical and Bioanalytical Chemistry
Dennis Kolosov, Maria Tauqir, Sabitha Rajaruban, Peter M Piermarini, Andrew Donini, Michael J O'Donnell
Classical studies have described in detail the complex and regionalized morphology of the Malpighian tubule (MT) in larval Lepidoptera. Recent studies revealed unusual aspects of ion transport in the Malpighian tubules of the larva of the cabbage looper, Trichoplusia ni. These included: cation reabsorption via secondary cells (SC); coupling of SCs to neighbouring PCs via gap junctions to enable reabsorption; and a reversal from cation secretion to reabsorption by the principal cells in the distal ileac plexus region of the in situ tubule in response to dietary ion loading...
June 14, 2018: Journal of Insect Physiology
M E Kelly, F Patterson, S O'Flynn, J Mulligan, A W Murphy
BACKGROUND: The purpose of this paper is to systematically review the literature with respect to stakeholder views of selection methods for medical school admissions. METHODS: An electronic search of nine databases was conducted between January 2000-July 2014. Two reviewers independently assessed all titles (n = 1017) and retained abstracts (n = 233) for relevance. Methodological quality of quantitative papers was assessed using the MERSQI instrument. The overall quality of evidence in this field was low...
June 15, 2018: BMC Medical Education
Veronika Némethová, Filip Rázga
Chronic myelogenous leukemia (CML) is commonly treated with tyrosine kinase inhibitors (TKIs) that inhibit the pro-leukemic activity of the BCR-ABL1 oncoprotein. Despite the therapeutic progress mediated by TKI use, off-target effects, treatment-induced drug resistance, and the limited effect of these drugs on CML stem cells (SCs) are major drawbacks frequently resulting in insufficient or unsustainable treatment. Therefore, intense research efforts have focused on development of improved TKIs and alternative treatment strategies to eradicate CML SCs...
June 14, 2018: Cancer Medicine
Tao Zheng, Tian-Biao Zhang, Chao-Liang Wang, Wei-Xing Zhang, Dong-Hui Jia, Fan Yang, Yang-Yang Sun, Xiao-Ju Ding, Rui Wang
Icariside II (ICA II) is used in erectile dysfunction treatment. Adipose tissue-derived stem cells (ADSCs) are efficient at improving erectile function. This study aimed to explore the action mechanism of ADSCs in improving erectile function. ADSCs were isolated from the adipose tissues of rats. Cell proliferation was determined using the Cell Counting Kit-8 (CCK-8) assay. The expressions of mRNA and protein were determined separately through qRT-PCR and western blot. The endogenous expressions of related genes were regulated using recombinant plasmids and cell transfection...
June 14, 2018: Molecules and Cells
Marco D T Scanavino, Ana Ventuneac, Carmita H N Abdo, Hermano Tavares, Maria L S Amaral, Bruna Messina, Sirlene C Reis, João P L B Martins, Jeffrey T Parsons
OBJECTIVE: There is a lack of studies on negative mood states and sexual risk behavior in men of all sexual orientations who seek treatment for excessive sexual behavior (ESB). We aim to examine sexual compulsivity (SC), anxiety, depression, and sexual risk behavior in a treatment-seeking sample of men and controls. METHODS: We enrolled 88 (37 [42%] gay or bisexual and 51 [58%] heterosexual) ESB outpatients and 64 controls. Assessments included the Sexual Compulsivity Scale (SCS), the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI), and sexual risk behaviors...
June 11, 2018: Revista Brasileira de Psiquiatria
Tahir Farooq, Kanwal Rehman, Arruje Hameed, Muhammad Sajid Hamid Akash
Type 1 diabetes mellitus (T1DM) is classified as an autoimmune disease which progressively results in the depletion of insulin-secreting β-cells. Consequently, the insulin secretion stops leading to hyperglycemic situations within the body. Under severe conditions, it also causes multi-organ diabetes-associated dysfunctionalities notably hypercoagulability, neuropathy, nephropathy, retinopathy, and sometimes organ failures. The prevalence of this disease has been noticed about 3% that has highlighted the serious concerns for healthcare professionals around the globe...
June 13, 2018: Advances in Experimental Medicine and Biology
William Alexander, George Miller, Preeya Alexander, Michael A Henderson, Angela Webb
BACKGROUND: Skin cancers are extremely common and the incidence increases with age. Care for patients with multiple or complicated skin cancers often require multidisciplinary input involving a general practitioner, dermatologist, plastic surgeon and/or radiation oncologist. Timely, efficient care of these patients relies on precise and effective communication between all parties. Until now, descriptions regarding the location of lesions on the scalp have been inaccurate, which can lead to error with the incorrect lesion being excised or biopsied...
June 12, 2018: ANZ Journal of Surgery
Yi Li, Lin-Lin Sun, Mei-Ling Sun, Hai-Nan Su, Xi-Ying Zhang, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang, Qi-Long Qin
Microorganisms display diverse biogeographic patterns in the three-dimensional contiguous seawater. The distance-decay relationship, the change in species composition similarity between different communities over a geographic distance, is a commonly observed biogeographic pattern. To study biogeographic patterns and the corresponding driving forces, the bacterial distance-decay patterns along the horizontal and vertical dimensions in the South China Sea (SCS) were investigated through the sequencing of partial 16 S rRNA gene regions...
June 11, 2018: Scientific Reports
Peng Wang, Jiangsheng Xie, Ke Xiao, Haihua Hu, Can Cui, Yaping Qiang, Ping Lin, Arivazhagan V, Lingbo Xu, Zhengrui Yang, Yuxin Yao, Tao Lu, Zihan Wang, Xuegong Yu, Deren Yang
Solution-processed organometallic halide perovskites have developed rapidly in both light emitting diodes (LEDs) and solar cells (SCs). These devices are fabricated with similar materials and architectures, leading to the emergence of perovskite-based light emitting solar cells (LESCs). The high-quality perovskite layer with reduced non-radiative recombination is crucial for achieving high performance device, even though the carrier behaviors are fundamentally different in those both functions. Here, CH3NH3PbBr3 quantum dots (QDs) are first introduced into the anti-solvent in the solution phase, serving as nucleation centers and inducing the growth of CH3NH3PbI3 films...
June 11, 2018: ACS Applied Materials & Interfaces
Nameer Haider, Dwight Ligham, Brett Quave, Kirk E Harum, Eduardo A Garcia, Christopher A Gilmore, Nathan Miller, Gregory A Moore, Amarpreet Bains, Kristen Lechleiter, Roshini Jain
OBJECTIVE: Spinal cord stimulation (SCS) for chronic intractable pain is typically delivered in pulses, classically programmed between approximately 20 and 100 Hz. Though some recent studies suggest that better pain relief is obtained, with only 10 kHz stimulation, other studies show that single-therapy trials do not always lead to permanent implantation. We evaluated SCS outcomes in subjects given trials with multiple waveforms who did not experience satisfactory trial relief with 10 kHz stimulation only...
June 11, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Kumar Jayant, Isabella Reccia, Francesco Virdis, A M James Shapiro
Introduction: The success of liver transplantation has been limited by the unavailability of suitable donor livers. The current organ preservation technique, i.e., static cold storage (SCS), is not suitable for marginal organs. Alternatively, normothermic machine perfusion (NMP) promises to recreate the physiological environment and hence holds promise for the better organ preservation. The objective of this systematic review is to provide an overview of the safety, benefits, and insight into the other potential useful parameters of NMP in the liver preservation...
2018: HPB Surgery: a World Journal of Hepatic, Pancreatic and Biliary Surgery
Jiao Jiao Zhang, Xian Zhong Wang, Huynh Luong Do, Nisansala Chandimali, Tae Yoon Kang, Nameun Kim, Mrinmoy Ghosh, Sang Baek Lee, Young Sun Mok, Seong Bong Kim, Taeho Kwon, Dong Kee Jeong
Non-thermal plasma treatment is an emerging innovative technique with a wide range of biological applications. This study was conducted to investigate the effect of a non-thermal dielectric barrier discharge plasma technique on immature chicken Sertoli cell (SC) viability and the regulatory role of microRNA (miR)-7450. Results showed that plasma treatment increased SC apoptosis in a time- and dose-dependent manner. Plasma-induced SC apoptosis possibly resulted from the excess production of reactive oxygen species via the suppression of antioxidant defense systems and decreased cellular energy metabolism through the inhibition of adenosine triphosphate (ATP) release and respiratory enzyme activity in the mitochondria...
June 8, 2018: Scientific Reports
Yanghai Zhang, Yang Cui, Xuelian Zhang, Yimin Wang, Jiayang Gao, Ting Yu, Xiaoyan Lv, Chuanying Pan
Steroidogenic acute regulatory protein (StAR), primarily expressed in Leydig cells (LCs) in the mammalian testes, is essential for testosterone biosynthesis and male fertility. However, no previous reports have explored the expression profiles, alternative splicing and genetic variations of StAR gene in pig. The aim of current study was to explore the expression profiles in different tissues and different types of testicular cells (LCs; spermatogonial stem cells, SSCs; Sertoli cells, SCs), to identify different splice variants and their expression levels, as well as to detect the indel polymorphism in pig StAR gene...
May 31, 2018: Theriogenology
Sharon Jiyoon Jung, Myung Geun Kook, Sungchul Kim, Kyung-Sun Kang, Kwang-Sup Soh
Homing of stem cells (SCs) to desired targets such as injured tissues remains a lingering problem in cell-based therapeutics. Studies on the biodistribution of intravenously administered SCs have shown the inefficacy of blood vessels as the homing path because most of the injected SCs are captured in the capillary beds of the lungs. We considered an alternative administration method utilizing the acupuncture meridians or the primo vascular system (PVS). We injected SCs at the acupoint Zusanli (ST-36) below the knee of a nude mouse with a spinal cord injured at the thoracic T9-10 vertebrae...
June 4, 2018: Journal of Acupuncture and Meridian Studies
Anna Babinska, Mariusz Kaszubowski, Krzysztof Sworczak
Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1) levels in patients with NFAIs and healthy subjects...
June 5, 2018: Endocrine Journal
Yi Zhang, Jie Li, Xuhua Cheng, Yinfeng Luo, Zhimao Mai, Si Zhang
The South China Sea (SCS) is the largest marginal sea in the western tropical Pacific Ocean and is characterized by complex physicochemical environments. To date, the biogeographic patterns of the microbial communities have rarely been reported at a basin scale in the SCS. In this study, the bacterial assemblages inhabiting the epipelagic zone across 110°E to 119°E along 14°N latitude were uncovered. The vertical stratification of both bacterial taxa and their potential functions were revealed. These results suggest that the water depth-specific environment is a driver of the vertical bacterioplankton distribution...
May 2018: Ecology and Evolution
Alejandro Alvarez-Prats, Ivana Bjelobaba, Zane Aldworth, Takashi Baba, Daniel Abebe, Yeun Ju Kim, Stanko S Stojilkovic, Mark Stopfer, Tamas Balla
Active membrane remodeling during myelination relies on phospholipid synthesis and membrane polarization, both of which are known to depend on inositol phospholipids. Here, we show that sciatic nerves of mice lacking phosphatidylinositol 4-kinase alpha (PI4KA) in Schwann cells (SCs) show substantially reduced myelin thickness with grave consequences on nerve conductivity and motor functions. Surprisingly, prolonged inhibition of PI4KA in immortalized mouse SCs failed to decrease plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 ) levels or PI 3-kinase (PI3K) activation, in spite of large reductions in plasma membrane PI4P levels...
June 5, 2018: Cell Reports
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