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https://www.readbyqxmd.com/read/27872148/proteomics-screen-identifies-class-i-rab11-fips-as-key-regulators-of-cytokinesis
#1
Carl Laflamme, Jacob A Galan, Khaled Ben El Kadhi, Antoine Méant, Carlos Zeledon, Sébastien Carréno, Philippe P Roux, Gregory Emery
The 14-3-3 protein family orchestrates a complex network of molecular interactions that regulates various biological processes. Owing to their role in regulating the cell cycle and protein trafficking, 14-3-3 proteins are prevalent in human diseases, such as cancer, diabetes and neurodegeneration. 14-3-3 proteins are expressed in all eukaryotic cells, suggesting that they mediate their biological functions through evolutionarily conserved protein interactions. To identify these core 14-3-3 client proteins, we used an affinity-based proteomics approach to characterize and compare the human and Drosophila 14-3-3 interactome...
November 21, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27337591/clustering-of-rab11-vesicles-in-influenza-a-virus-infected-cells-creates-hotspots-containing-the-eight-viral-ribonucleoproteins
#2
Sílvia Vale-Costa, Maria João Amorim
Influenza A virus is an important human pathogen causative of yearly epidemics and occasional pandemics. The ability to replicate within the host cell is a determinant of virulence, amplifying viral numbers for host-to-host transmission. This process requires multiple rounds of entering permissive cells, replication, and virion assembly at the plasma membrane, the site of viral budding and release. The assembly of influenza A virus involves packaging of several viral (and host) proteins and of a segmented genome, composed of eight distinct RNAs in the form of viral ribonucleoproteins (vRNPs)...
June 23, 2016: Small GTPases
https://www.readbyqxmd.com/read/26933086/rab11-fip1c-is-a-critical-negative-regulator-in-erbb2-mediated-mammary-tumor-progression
#3
Pierre-Luc Boulay, Louise Mitchell, Jason Turpin, Julie-Émilie Huot-Marchand, Cynthia Lavoie, Virginie Sanguin-Gendreau, Laura Jones, Shreya Mitra, Julie M Livingstone, Shirley Campbell, Michael Hallett, Gordon B Mills, Morag Park, Lewis Chodosh, Douglas Strathdee, Jim C Norman, William J Muller
Rab coupling protein (FIP1C), an effector of the Rab11 GTPases, including Rab25, is amplified and overexpressed in 10% to 25% of primary breast cancers and correlates with poor clinical outcome. Rab25 is also frequently silenced in triple-negative breast cancer, suggesting its ability to function as either an oncogene or a tumor suppressor, depending on the breast cancer subtype. However, the pathobiologic role of FIP family members, such as FIP1C, in a tumor-specific setting remains elusive. In this study, we used ErbB2 mouse models of human breast cancer to investigate FIP1C function in tumorigenesis...
May 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26792722/rab11-fip2-promotes-colorectal-cancer-migration-and-invasion-by-regulating-pi3k-akt-mmp7-signaling-pathway
#4
Chang-long Xu, Jian-zhang Wang, Xuan-ping Xia, Chen-wei Pan, Xiao-xiao Shao, Sheng-Long Xia, Shou-xing Yang, Bo Zheng
Rab11-family interacting proteins (Rab11-FIPs) belong to an evolutionarily conserved protein family and act as effector molecules for the Rab11 family of small GTPases. Recent evidence suggests that Rab11-FIPs have important roles in tumor progression and metastasis. However, the contribution of Rab11-FIPs to colorectal carcinoma (CRC) remains elusive. Our study focuses on elucidating the role of Rab11-FIP2 in the migration and invasion of colorectal cancer cells. We firstly found upregulation of Rab11-FIP2 in CRC tissues compared with peritumor tissues by oncomine data-mining analysis, western blot analysis and immunohistochemistry (IHC) analysis, respectively...
February 5, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26790954/rab11-fip1a-regulates-early-trafficking-into-the-recycling-endosomes
#5
Jenny C Schafer, Rebecca E McRae, Elizabeth H Manning, Lynne A Lapierre, James R Goldenring
The Rab11 family of small GTPases, along with the Rab11-family interacting proteins (Rab11-FIPs), are critical regulators of intracellular vesicle trafficking and recycling. We have identified a point mutation of Threonine-197 site to an Alanine in Rab11-FIP1A, which causes a dramatic dominant negative phenotype when expressed in HeLa cells. The normally perinuclear distribution of GFP-Rab11-FIP1A was condensed into a membranous cisternum with almost no GFP-Rab11-FIP1A(T197A) remaining outside of this central locus...
January 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/26360025/analyzing-the-functions-of-rab11-effector-proteins-during-cell-division
#6
Rytis Prekeris
Recycling endosomes recently have emerged as major regulators of cytokinesis and abscission steps of cell division. Rab11-endosomes in particular were shown to transport proteins to the mitotic ingression furrow and play a key role in establishing the abscission site. Rab11 GTPase functions by binding and activating various effector proteins, such as Rab11 family interacting proteins (FIPs). FIPs appear to be at the core of many Rab11 functions, with FIP3 playing a role in targeting of the Rab11-endosomes during mitosis...
2015: Methods in Cell Biology
https://www.readbyqxmd.com/read/26032412/structure-function-analyses-of-the-interactions-between-rab11-and-rab14-small-gtpases-with-their-shared-effector-rab-coupling-protein-rcp
#7
Patrick Lall, Andrew J Lindsay, Sara Hanscom, Tea Kecman, Elizabeth S Taglauer, Una M McVeigh, Edward Franklin, Mary W McCaffrey, Amir R Khan
Rab GTPases recruit effector proteins, via their GTP-dependent switch regions, to distinct subcellular compartments. Rab11 and Rab25 are closely related small GTPases that bind to common effectors termed the Rab11 family of interacting proteins (FIPs). The FIPs are organized into two subclasses (class I and class II) based on sequence and domain organization, and both subclasses contain a highly conserved Rab-binding domain at their C termini. Yeast two-hybrid and biochemical studies have revealed that the more distantly related Rab14 also interacts with class I FIPs...
July 24, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25210648/distinct-patterns-of-phosphatidylserine-localization-within-the-rab11a-containing-recycling-system
#8
Nicholas W Baetz, James R Goldenring
The Rab11 GTPases and Rab11 family-interacting proteins (Rab11-FIPs) define integrated yet distinct compartments within the slow recycling pathway. The lipid content of these compartments is less well understood, although past studies have indicated phosphatidylserine (PS) is an integral component of recycling membranes. We sought to identify key differences in the presence of PS within Rab and Rab11-FIP containing membranes. We used live cell fluorescence microscopy and structured illumination microscopy to determine whether the previously published LactC2 probe for PS displays differential patterns of overlap with various Rab GTPases and Rab11-FIPs...
2014: Cellular Logistics
https://www.readbyqxmd.com/read/24040321/the-rab11-effector-protein-fip1-regulates-adiponectin-trafficking-and-secretion
#9
Brian P Carson, Josep Maria Del Bas, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real, Silvia Mora
Adiponectin is an adipokine secreted by white adipocytes involved in regulating insulin sensitivity in peripheral tissues. Secretion of adiponectin in adipocytes relies on the endosomal system, however, the intracellular machinery involved in mediating adiponectin release is unknown. We have previously reported that intracellular adiponectin partially compartmentalizes with rab 5 and rab11, markers for the early/sorting and recycling compartments respectively. Here we have examined the role of several rab11 downstream effector proteins (rab11 FIPs) in regulating adiponectin trafficking and secretion...
2013: PloS One
https://www.readbyqxmd.com/read/23283983/rab11-family-interacting-proteins-define-spatially-and-temporally-distinct-regions-within-the-dynamic-rab11a-dependent-recycling-system
#10
Nicholas W Baetz, James R Goldenring
The Rab11-family interacting proteins (Rab11-FIPs) facilitate Rab11-dependent vesicle recycling. We hypothesized that Rab11-FIPs define discrete subdomains and carry out temporally distinct roles within the recycling system. We used live-cell deconvolution microscopy of HeLa cells expressing chimeric fluorescent Rab11-FIPs to examine Rab11-FIP localization, transferrin passage through Rab11-FIP-containing compartments, and overlap among Rab11-FIPs within the recycling system. FIP1A, FIP2, and FIP5 occupy widely distributed mobile tubules and vesicles, whereas FIP1B, FIP1C, and FIP3 localize to perinuclear tubules...
March 2013: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/22348143/tumor-susceptibility-gene-101-tsg101-is-a-novel-binding-partner-for-the-class-ii-rab11-fips
#11
Conor P Horgan, Sara R Hanscom, Eoin E Kelly, Mary W McCaffrey
The Rab11-FIPs (Rab11-family interacting proteins; henceforth, FIPs) are a family of Rab11a/Rab11b/Rab25 GTPase effector proteins implicated in an assortment of intracellular trafficking processes. Through proteomic screening, we have identified TSG101 (tumor susceptibility gene 101), a component of the ESCRT-I (endosomal sorting complex required for transport) complex, as a novel FIP4-binding protein, which we find can also bind FIP3. We show that α-helical coiled-coil regions of both TSG101 and FIP4 mediate the interaction with the cognate protein, and that point mutations in the coiled-coil regions of both TSG101 and FIP4 abrogate the interaction...
2012: PloS One
https://www.readbyqxmd.com/read/21731653/apical-transport-of-influenza-a-virus-ribonucleoprotein-requires-rab11-positive-recycling-endosome
#12
Fumitaka Momose, Tetsuya Sekimoto, Takashi Ohkura, Shuichi Jo, Atsushi Kawaguchi, Kyosuke Nagata, Yuko Morikawa
Influenza A virus RNA genome exists as eight-segmented ribonucleoprotein complexes containing viral RNA polymerase and nucleoprotein (vRNPs). Packaging of vRNPs and virus budding take place at the apical plasma membrane (APM). However, little is known about the molecular mechanisms of apical transport of newly synthesized vRNP. Transfection of fluorescent-labeled antibody and subsequent live cell imaging revealed that punctate vRNP signals moved along microtubules rapidly but intermittently in both directions, suggestive of vesicle trafficking...
2011: PloS One
https://www.readbyqxmd.com/read/21686255/rab11-fip2-influences-multiple-components-of-the-endosomal-system-in-polarized-mdck-cells
#13
Nicole A Ducharme, Amy-Joan L Ham, Lynne A Lapierre, James R Goldenring
The Rab11 Family Interacting Proteins (Rab11-FIPs) are hypothesized to regulate sequential steps in the apical recycling and transcytotic pathways of polarized epithelial cells. Previous studies have suggested that Rab11-FIP proteins assemble into multi-protein complexes regulating plasma membrane recycling. Rab11-FIP2 interacts with both myosin Vb and Rab11. Recent investigations have noted that that Rab11-FIP2 mutants [Rab11-FIP2(129-512), also designated Rab11-FIP2(ΔC2) and Rab11-FIP2(S229A, R413G), also designated Rab11-FIP2(SARG)], are potent inhibitors of transcytosis in polarized MDCK cells...
March 2011: Cellular Logistics
https://www.readbyqxmd.com/read/21642507/rab11-function-in-trypanosoma-brucei-identification-of-conserved-and-novel-interaction-partners
#14
Carme Gabernet-Castello, Kelly N Dubois, Camus Nimmo, Mark C Field
The Ras-like GTPase Rab11 is implicated in multiple aspects of intracellular transport, including maintenance of plasma membrane composition and cytokinesis. In metazoans, these functions are mediated in part via coiled-coil Rab11-interacting proteins (FIPs) acting as Rab11 effectors. Additional interaction between Rab11 and the exocyst subunit Sec15 connects Rab11 with exocytosis. We find that FIPs are metazoan specific, suggesting that other factors mediate Rab11 functions in nonmetazoans. We examined Rab11 interactions in Trypanosoma brucei, where endocytosis is well studied and the role of Rab11 in recycling well documented...
August 2011: Eukaryotic Cell
https://www.readbyqxmd.com/read/19754446/the-dynamic-rab11-fips
#15
REVIEW
Conor P Horgan, Mary W McCaffrey
The Rab11-FIPs (Rab11-family interacting proteins; also known as FIPs) constitute an evolutionarily conserved protein family that act as effector molecules for multiple Rab and Arf (ADP-ribosylation factor) GTPases. They were initially characterized by their ability to bind Rab11 subfamily members via a highly-conserved C-terminal RBD (Rab11-binding domain). Resolution of the crystal structure of Rab11 in complex with FIPs revealed that the RBD mediates homodimerization of the FIP molecules, creating two symmetrical interfaces for Rab11 binding and leading to the formation of a heterotetrameric complex between two FIP and two Rab11 molecules...
October 2009: Biochemical Society Transactions
https://www.readbyqxmd.com/read/19702578/class-i-rab11-family-interacting-proteins-are-binding-targets-for-the-rab14-gtpase
#16
Eoin E Kelly, Conor P Horgan, Christine Adams, Tomasz M Patzer, Deirdre M Ní Shúilleabháin, Jim C Norman, Mary W McCaffrey
BACKGROUND INFORMATION: Rab11 and Rab14 are two related Rab GTPases that are believed to function in endosomal recycling and Golgi/endosome transport processes. We, and others, have identified a group of proteins that interact with Rab11 and function as Rab11 effectors, known as the Rab11-FIPs (family interacting proteins). This protein family has been sub-classified into two groups - class I FIPs [FIP2, RCP (Rab coupling protein) and Rip11 (Rab11-interacting protein)] and class II FIPs (FIP3 and FIP4)...
October 12, 2009: Biology of the Cell
https://www.readbyqxmd.com/read/19609864/polarized-endocytic-transport-the-roles-of-rab11-and-rab11-fips-in-regulating-cell-polarity
#17
REVIEW
Jian Jing, Rytis Prekeris
Endocytic transport plays a vital role in the establishment and maintenance of cell polarity. Many studies have demonstrated that endosome-dependent protein targeting is required for polarization of epithelial cells and neurons. Endocytic transport regulates several highly polarized cellular events, such as cell motility and division. Rab11 GTPase has been shown to be a master regulator of protein transport via recycling endosomes, and many recent studies have focused on the molecular machinery that mediates Rab11-dependent endocytic protein transport in polarized cells...
September 2009: Histology and Histopathology
https://www.readbyqxmd.com/read/19119858/disorder-and-structure-in-the-rab11-binding-domain-of-rab11-family-interacting-protein-2
#18
Jie Wei, Yuqi Liu, Kakoli Bose, Gillian D Henry, James D Baleja
Rab11 plays a central role in plasma membrane recycling which returns cellular receptors for reuse at the cell surface. A recently identified family of Rab11 interacting proteins (FIP) includes FIP2. The C-terminal region of FIP2 is essential for colocalization with Rab11 on early endosomes and for enabling formation of higher-order oligomers. Rab11 binding and oligomerization of FIP2 are separable. Here we have determined the three-dimensional structure of the 40-residue coiled-coil oligomerization domain of FIP2 in the absence of Rab11 using NMR methods...
January 27, 2009: Biochemistry
https://www.readbyqxmd.com/read/17626244/rab11-fip2-regulates-differentiable-steps-in-transcytosis
#19
Nicole A Ducharme, Janice A Williams, Asli Oztan, Gerard Apodaca, Lynne A Lapierre, James R Goldenring
Transcytosis through the apical recycling system of polarized cells is regulated by Rab11a and a series of Rab11a-interacting proteins. We have identified a point mutant in Rab11 family interacting protein 2 (Rab11-FIP2) that alters the function of Rab11a-containing trafficking systems. Rab11-FIP2(S229A/R413G) or Rab11-FIP2(R413G) cause the formation of a tubular cisternal structure containing Rab11a and decrease the rate of polymeric IgA transcytosis. The R413G mutation does not alter Rab11-FIP interactions with any known binding partners...
September 2007: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/17030804/structural-basis-for-rab11-dependent-membrane-recruitment-of-a-family-of-rab11-interacting-protein-3-fip3-arfophilin-1
#20
Tomoo Shiba, Hiroshi Koga, Hye-Won Shin, Masato Kawasaki, Ryuichi Kato, Kazuhisa Nakayama, Soichi Wakatsuki
Family of Rab11-interacting protein (FIP)3/Arfophlin-1 and FIP4/Arfophilin-2 are dual effectors for Rab11 and ADP ribosylation factor (ARF)5/ARF6, which are involved in membrane delivery from recycling endosomes to the plasma membrane during cytokinesis. Here, we define the distinct C-terminal binding regions of FIP3 and FIP4 for Rab11 and ARF5/ARF6. Furthermore, we determined the crystal structure of Rab11 in complex with the Rab11-binding domain (RBD) of FIP3. The long amphiphilic alpha-helix of FIP3-RBD forms a parallel coiled-coil homodimer, with two symmetric interfaces with two Rab11 molecules...
October 17, 2006: Proceedings of the National Academy of Sciences of the United States of America
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