Christian Fernandez, Andres Burgos, Diego Morales, Roberto Rosales-Rojas, Javiera Canelo, Ariela Vergara-Jaque, Gabriel Viliod Vieira, Rodrigo Alberto Alves da Silva, Katiuchia Uzzun Sales, Michael J Conboy, Eun Ji Bae, Kang-Sik Park, Vicente A Torres, Mauricio Garrido, Oscar Cerda, Irina M Conboy, Mónica Cáceres
Aging is a gradual biological process characterized by a decrease in cellular and organism functions. Aging-related processes involve changes in the expression and activity of several proteins. Here, we identified the transmembrane protease serine 11a (TMPRSS11a) as a new age-specific protein that plays an important role in skin wound healing. TMPRSS11a levels increased with age in rodent and human skin and gingival samples. Strikingly, overexpression of TMPRSS11a decreased cell migration and spreading, and inducing cellular senescence...
May 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology