keyword
https://read.qxmd.com/read/35090553/the-integrin-beta1-modulator-tirofiban-prevents-adipogenesis-and-obesity-by-the-overexpression-of-integrin-linked-kinase-a-pre-clinical-approach-in-vitro-and-in-vivo
#21
JOURNAL ARTICLE
S de Frutos, M Griera, M Hatem-Vaquero, S Campillo, E Gutiérrez-Calabres, D García-Ayuso, M Pardo, L Calleros, M Rodríguez-Puyol, D Rodríguez-Puyol
BACKGROUND: Obesity is caused by the enlargement of the white adipose tissue (WAT) depots, characterized by the hypertrophic enlargement of malfunctioning adipocytes within WAT which increases the storage of triglycerides (TG) in the lipid droplets (LD). Adipogenesis pathways as well as the expression and activity of some extracellular matrix receptors integrins are upregulated. Integrinβ1 (INTB1) is the main isoform involved in WAT remodeling during obesity and insulin resistance-related diseases...
January 28, 2022: Cell & Bioscience
https://read.qxmd.com/read/35060996/erianin-controls-collagen-mediated-retinal-angiogenesis-via-the-rhoa-rock1-signaling-pathway-induced-by-the-alpha2-beta1-integrin-collagen-interaction
#22
JOURNAL ARTICLE
Xueke Li, Xiaoxue Liu, Yue Xing, Lingyan Zeng, Xin Liu, Huangxuan Shen, Jin Ma
Purpose: Erianin has been reported to inhibit tumor activity by suppressing the expression of integrins. It is hypothesized that erianin can inhibit retinal neovascularization in collagen by suppressing the expression of integrins. With an aim to test this hypothesis, the regulation of erianin on collagen-mediated retinal angiogenesis via the Ras homolog gene family member A (RhoA)/Rho-associated coiled-coil containing protein kinase 1 (ROCK1) signaling pathway induced by α2 and β1 integrin-collagen interactions was investigated...
January 3, 2022: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/34869589/evidence-for-quantum-chemical-effects-in-receptor-ligand-binding-between-integrin-and-collagen-fragments-a-computational-investigation-with-an-impact-on-tissue-repair-neurooncolgy-and-glycobiology
#23
JOURNAL ARTICLE
Thomas Eckert, Jan von Cosel, Benedict Kamps, Hans-Christian Siebert, Ruiyan Zhang, Ning Zhang, Konstantinos Gousias, Athanasios K Petridis, Dimitrios Kanakis, Konstantin Falahati
The collagen-integrin interactions are mediated by the doubly charged Mg2+ cation. In nature this cation seems to have the optimal binding strength to stabilize this complex. It is essential that the binding is not too weak so that the complex becomes unstable, however, it is also of importance that the ligand-receptor binding is still labile enough so that the ligand can separate from the receptor in a suited environment. In the case of crystal growing for experimentally useful integrin-collagen fragment complexes it turned out that Co2+ cations are ideal mediators to form stable complexes for such experiments...
2021: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/34616507/involvement-of-integrin-activating-peptides-derived-from-tenascin-c-in-colon-cancer-progression
#24
REVIEW
Motomichi Fujita, Hideo Suzuki, Fumio Fukai
Tenascin-C (TNC) is an adhesion modulatory protein present in the extracellular matrix that is highly expressed in several malignancies, including colon cancer. Although TNC is considered a negative prognostic factor for cancer patients, the substantial role of the TNC molecule in colorectal carcinogenesis and its malignant progression is poorly understood. We previously found that TNC has a cryptic functional site and that a TNC peptide containing this site, termed TNIIIA2, can potently and persistently activate beta1-integrins...
September 15, 2021: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/34302219/cg-caomecs-clinical-grade-cultured-autologous-oral-mucosal-epithelial-cell-sheet
#25
JOURNAL ARTICLE
Kavita Narwani, Jeremy Stark, Daileen Cortez, Isaac Yang, Christian Au, Alissa Diaz, Catalina Guerra, Yutaka Niihara, Fawzia Bardag-Gorce
The present study reports the feasibility and successful production of rabbit cG-CAOMECS, designed to reconstruct corneal epithelium of patients with bilateral limbal stem cell deficiency. To produce a safe, chemically defined and FDA compliant cG-CAOMECS, oral mucosal epithelial cells were isolated from a biopsy of rabbit buccal tissue and seeded on a cGMP-certified cell culture surface coated with GMP-grade extracellular matrix. A newly designed clinical-grade medium (KaFa™ medium) was utilized to carry out cell expansion...
July 24, 2021: Cell and Tissue Research
https://read.qxmd.com/read/34208249/higher-integrin-alpha-3-beta1-expression-in-papillary-thyroid-cancer-is-associated-with-worst-outcome
#26
JOURNAL ARTICLE
Lorenza Mautone, Carlo Ferravante, Anna Tortora, Roberta Tarallo, Giorgio Giurato, Alessandro Weisz, Mario Vitale
Integrins are cell-extracellular matrix adhesion molecules whose expression level undergoes quantitative changes upon neoplastic transformation and are considered functionally related to the development of cancer metastasis. We analyzed the largest mRNA-seq dataset available to determine the expression pattern of integrin family subunits in papillary thyroid carcinomas (PTC). ITGA2, 3, 6, V, and ITGB1 integrin subunits were overexpressed in PTC compared to normal thyroid tissue. The PTC histology variants "classical" and "tall cell" displayed a similar integrin expression profile with a higher level of ITGA3, ITGAV, and ITGB1, which differed from that of the "follicular" variant...
June 11, 2021: Cancers
https://read.qxmd.com/read/34156983/extracellular-matrix-protein-laminin-%C3%AE-1-regulates-pain-sensitivity-and-anxiodepression-like-behaviors-in-mice
#27
JOURNAL ARTICLE
Zhen-Zhen Li, Wen-Juan Han, Zhi-Chuan Sun, Yun Chen, Jun-Yi Sun, Guo-Hong Cai, Wan-Neng Liu, Tao-Zhi Wang, Yang-Dan Xie, Hong-Hui Mao, Fei Wang, Sui-Bin Ma, Fu-Dong Wang, Rou-Gang Xie, Sheng-Xi Wu, Ceng Luo
Patients with neuropathic pain often experience comorbid psychiatric disorders. Cellular plasticity in the anterior cingulate cortex (ACC) is assumed as a critical interface for pain perception and emotion. However, substantial efforts thus far are focused on intracellular mechanisms of plasticity rather than extracellular alterations that might trigger and facilitate intracellular changes. Laminin is a key element of extracellular matrix (ECM) consisting of one α-, β- and γ-chain and implicated in several pathophysiological processes...
June 22, 2021: Journal of Clinical Investigation
https://read.qxmd.com/read/34147653/beta1-integrin-hedgehog-gli1-signaling-pathway-fuels-the-diameter-dependent-osteoblast-differentiation-on-different-tio-2-nanotubes-the-optimal-diameter-nanotubes-for-osteoblast-differentiation
#28
JOURNAL ARTICLE
Yirui Xie, Xiaozhu Chen, Xuying Zheng, Ling Li, Jieyin Li, Yuling Xu, Junbing He, Yao Lin
Micro/nanotextured topographies (MNTs) can modulate cell-biomaterial interactions mostly by their controllable geometrics. Among them, TiO2 nanotubes, regarded as having a highly controllable nanoscale geometry, have been extensively investigated and applied and significantly affect diameter-dependent cell biological behaviors. In this study, we used five typical MNTs decorated with TiO2 nanotubes with diameters of 30, 50, 70, 100 and 120 nm to explore the optimal nanotube diameter for improving the biofunctional properties and to more deeply understand the underlying mechanisms by which these MNTs affect osteogenic differentiation by revealing the effect of beta1-integrin/Hedgehog-Gli1 signaling on this process...
June 17, 2021: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/33978371/identification-of-key-genes-and-pathways-associated-with-hepatosplenic-t-cell-lymphoma-hstcl-by-bioinformatics-analysis
#29
JOURNAL ARTICLE
Jun Du, Guang Lu, Bin Xu, Xin-Le Han, Wei-Wei Mou
BACKGROUND: Prognosis of Hepatosplenic T-Cell Lymphoma (HSTCL) is very poor, while the molecular mechanism of this disease has rarely been investigated and remains mysterious. The aim of the study is to screen differentially expressed genes (DEGs) of patients with HSTCL and normal controls, explore the pathogenesis, and provide guidance for the gene diagnosis and precise treatment of HSTCL. METHODS: The genetic chip data GSE57520 of HSTCL was searched from the GEO database, and the quality control and DEGs screening were performed through BART online tools...
May 1, 2021: Clinical Laboratory
https://read.qxmd.com/read/33908663/tmprss11a-is-a-novel-age-altered-tissue-specific-regulator-of-migration-and-wound-healing
#30
JOURNAL ARTICLE
Christian Fernandez, Andres Burgos, Diego Morales, Roberto Rosales-Rojas, Javiera Canelo, Ariela Vergara-Jaque, Gabriel Viliod Vieira, Rodrigo Alberto Alves da Silva, Katiuchia Uzzun Sales, Michael J Conboy, Eun Ji Bae, Kang-Sik Park, Vicente A Torres, Mauricio Garrido, Oscar Cerda, Irina M Conboy, Mónica Cáceres
Aging is a gradual biological process characterized by a decrease in cellular and organism functions. Aging-related processes involve changes in the expression and activity of several proteins. Here, we identified the transmembrane protease serine 11a (TMPRSS11a) as a new age-specific protein that plays an important role in skin wound healing. TMPRSS11a levels increased with age in rodent and human skin and gingival samples. Strikingly, overexpression of TMPRSS11a decreased cell migration and spreading, and inducing cellular senescence...
May 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/33675651/par3-integrin-%C3%AE-1-regulates-embryo-adhesion-via-changing-endometrial-luminal-epithelium-polarity
#31
JOURNAL ARTICLE
Jiali Peng, Xiaoling Li, Yan Zhang, Jian Hu, Yunjie Shang, Yuchen Yin, Zhuoni Xiao
OBJECTIVE: To investigate the pathophysiological significance of Par3 and integrin β1 with regards to the functionality of the endometrial luminal epithelium (LE). DESIGN: Laboratory study. SETTING: University research laboratory. PATIENTS: Analysis involved endometrial aspirates and human endometrial epithelial cells (HEC-1A cells and RL95-2 cells). INTERVENTIONS: We first examined the expression and localization of Par3 and integrin β1 in HEC-1A cells and RL95-2 cells...
March 2, 2021: Biology of Reproduction
https://read.qxmd.com/read/33187358/partial-sperm-beta1-integrin-subunit-deletion-proves-its-involvement-in-mouse-gamete-adhesion-fusion
#32
JOURNAL ARTICLE
Virginie Barraud-Lange, Côme Ialy-Radio, Céline Chalas, Isabelle Holtzmann, Jean-Philippe Wolf, Sandrine Barbaux, Ahmed Ziyyat
We have previously shown, using antibodies, that the sperm alpha6beta1 integrin is involved in mouse gamete fusion in vitro. Here we report the conditional knockdown of the sperm Itgb1 gene. It induced a drastic failure of sperm fusogenic ability with sperm accumulation in the perivitelline space of in vitro inseminated oocytes deleted or not for the Itgb1 gene. These data demonstrate that sperm, but not oocyte, beta1 integrin subunit is involved in gamete adhesion/fusion. Curiously, knockdown males were fertile in vivo probably because of the incomplete Cre-mediated deletion of the sperm Itgb1 floxed gene...
November 11, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/33151388/gefitinib-induces-egfr-and-%C3%AE-5%C3%AE-1-integrin-co-endocytosis-in-glioblastoma-cells
#33
JOURNAL ARTICLE
Anne-Florence Blandin, Elisabete Cruz Da Silva, Marie-Cécile Mercier, Oleksandr Glushonkov, Pascal Didier, Stéphane Dedieu, Cristophe Schneider, Jessica Devy, Nelly Etienne-Selloum, Monique Dontenwill, Laurence Choulier, Maxime Lehmann
Overexpression of EGFR drives glioblastomas (GBM) cell invasion but these tumours remain resistant to EGFR-targeted therapies such as tyrosine kinase inhibitors (TKIs). Endocytosis, an important modulator of EGFR function, is often dysregulated in glioma cells and is associated with therapy resistance. However, the impact of TKIs on EGFR endocytosis has never been examined in GBM cells. In the present study, we showed that gefitinib and other tyrosine kinase inhibitors induced EGFR accumulation in early-endosomes as a result of an increased endocytosis...
March 2021: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/32671583/mesenchymal-stem-cell-derived-exosomal-microrna-3940-5p-inhibits-colorectal-cancer-metastasis-by-targeting-integrin-%C3%AE-6
#34
JOURNAL ARTICLE
Tao Li, Yingchun Wan, Ziyuan Su, Jiayu Li, Minna Han, Changyu Zhou
BACKGROUND: Exosomes are potential tools for disease control by regulating intercellular communication through carrying proteins and RNAs between cells or remote organs. Exosome activities have aroused wide concerns in cancer biology and malignancy control. AIMS: This study was performed to explore the roles of mesenchymal stem cell (MSC)-derived exosomes in colorectal cancer (CRC) progression. METHODS: MSC-exosomal microRNAs (miRNAs) in CRC tissues were analyzed, and aberrantly expressed miRNAs in CRC tissues were obtained from the data available on the GEO database...
July 15, 2020: Digestive Diseases and Sciences
https://read.qxmd.com/read/32421320/molecular-simulation-of-%C3%AE-v%C3%AE-6-integrin-inhibitors
#35
JOURNAL ARTICLE
Ellen E Guest, Steven A Oatley, Simon J F Macdonald, Jonathan Darrell Hirst
The urgent need for new treatments for the chronic lung disease idiopathic pulmonary fibrosis (IPF) motivates research into antagonists of the RGD binding integrin, alphavbeta6 , a protein linked to the initiation and progression of the disease. Molecular dynamics (MD) simulations of alphavbeta6 in complex with its natural ligand, pro-TGF-beta1, show the persistence over time of a bidentate Arg-Asp ligand-receptor interaction and a metal chelate interaction between an aspartate on the ligand and an Mg2+ ¸ ion in the active site...
May 18, 2020: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/32049010/secreted-pyruvate-kinase-m2-promotes-lung-cancer-metastasis-through-activating-the-integrin-beta1-fak-signaling-pathway
#36
JOURNAL ARTICLE
Caihong Wang, Shaosen Zhang, Jie Liu, Yang Tian, Boyuan Ma, Siran Xu, Yan Fu, Yongzhang Luo
Cancer cell-derived secretomes have been documented to play critical roles in cancer progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved in various steps of tumor progression, which can offer strategies to fight cancer. Herein, we identify lung cancer progression-associated secretome signatures using mass spectrometry analysis. Among them, PKM2 is verified to be highly expressed and secreted in lung cancer cells and clinical samples. Functional analyses demonstrates that secreted PKM2 facilitates tumor metastasis...
February 11, 2020: Cell Reports
https://read.qxmd.com/read/31710084/koebner-phenomenon-leading-to-formation-of-new-psoriatic-lesions-evidences-and-mechanisms
#37
JOURNAL ARTICLE
Yong-Zhi Ji, Shi-Rui Liu
Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggests that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections, and striae, etc...
November 11, 2019: Bioscience Reports
https://read.qxmd.com/read/31501278/acquired-resistance-to-egfr-tkis-mediated-by-tgf%C3%AE-1-integrin-%C3%AE-3-signaling-in-egfr-mutant-lung-cancer
#38
JOURNAL ARTICLE
Caiyun Wang, Tao Wang, Dacheng Lv, Ling Li, Jinnan Yue, Hong-Zhuan Chen, Lu Xu
Investigation of novel molecular mechanisms is essential to develop strategies to overcome acquired resistance to EGFR tyrosine kinase inhibitors (TKI). Integrin has been demonstrated as a regulator of cancer progression. The aim of this study was to identify which specific integrins are involved and regulated in acquired resistance to EGFR TKIs in EGFR-mutant lung cancer. The expression levels of integrin subunits were examined in EGFR-mutant lung cancer cells and xenograft tumors with acquired resistance to EGFR TKIs...
December 2019: Molecular Cancer Therapeutics
https://read.qxmd.com/read/31452837/inactivation-of-beta1-integrin-induces-proteasomal-degradation-of-myc-oncoproteins
#39
JOURNAL ARTICLE
Manabu Sasada, Takuya Iyoda, Tatsufumi Asayama, Yusuke Suenaga, Shunsuke Sakai, Naoya Kase, Hiroaki Kodama, Sana Yokoi, Yoichiro Isohama, Fumio Fukai
The MYC family oncogenes ( MYC , MYCN , and MYCL ) contribute to the genesis of many human cancers. Among them, amplification of the MYCN gene and over-expression of N-Myc protein are the most reliable risk factors in neuroblastoma patients. On the other hand, we previously found that a peptide derived from fibronectin, termed FNIII14, is capable of inducing functional inactivation in β1-integrins. Here, we demonstrate that inactivation of β1-integrin by FNIII14 induced proteasomal degradation in N-Myc of neuroblastoma cells with MYCN amplification...
August 13, 2019: Oncotarget
https://read.qxmd.com/read/31193165/e-cadherin-loss-in-rmg-1-cells-inhibits-cell-migration-and-its-regulation-by-rho-gtpases
#40
JOURNAL ARTICLE
Misako Haraguchi, Tomoko Fukushige, Takuro Kanekura, Masayuki Ozawa
E-cadherin is an adherens junction protein that forms intercellular contacts in epithelial cells. Downregulation of E-cadherin is frequently observed in epithelial tumors and it is a hallmark of epithelial-mesenchymal transition (EMT). However, recent findings suggest that E-cadherin plays a more complex role in certain types of cancers. Previous studies investigating the role of E-cadherin mainly used gene-knockdown systems; therefore, we used the CRISPR/Cas9n system to develop E-cadherin-knockout (EcadKO) ovarian cancer RMG-1 cell to clarify the role of E-cadherin in RMG-1 cells...
July 2019: Biochemistry and Biophysics Reports
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