Scott M Haake, Erin J Plosa, Jonathan A Kropski, Lindsay A Venton, Anupama Reddy, Fabian Bock, Betty T Chang, Allen J Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V Polosukhin, Olga M Viquez, Angela Jones, Wentian Luo, Matthew H Wilson, W Kimryn Rathmell, Pierre P Massion, Ambra Pozzi, Timothy S Blackwell, Roy Zent
Integrins - the principal extracellular matrix (ECM) receptors of the cell - promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer therapeutics have disrupted integrin-ECM interactions, which are viewed as critical for integrin functions. However, such agents have failed to improve cancer patient outcomes. We show that the highly expressed integrin β1 subunit is required for lung adenocarcinoma development in a carcinogen-induced mouse model...
August 8, 2022: JCI Insight