keyword
https://read.qxmd.com/read/38338996/mechanosensitive-cation-channel-piezo1-is-involved-in-renal-fibrosis-induction
#1
REVIEW
Marta Drobnik, Jakub Smólski, Łukasz Grądalski, Szymon Niemirka, Ewelina Młynarska, Jacek Rysz, Beata Franczyk
Renal fibrosis, the result of different pathological processes, impairs kidney function and architecture, and usually leads to renal failure development. Piezo1 is a mechanosensitive cation channel highly expressed in kidneys. Activation of Piezo1 by mechanical stimuli increases cations influx into the cell with slight preference of calcium ions. Two different models of Piezo1 activation are considered: force through lipid and force through filament. Expression of Piezo1 on mRNA and protein levels was confirmed within the kidney...
January 31, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38254031/cancer-associated-fibroblast-derived-extracellular-vesicles-promote-lymph-node-metastases-in-oral-cavity-squamous-cell-carcinoma-by-encapsulating-itgb1-and-bmi1
#2
JOURNAL ARTICLE
Tianzhu Lv, Hongjing Liu, Ling Mao, Yanrong Song, Lili Liao, Kun Zhong, Binbin Shuai, Yingkun Luo, Tingting Guo, Wentao Huang, Shenyingjie Zhang
BACKGROUND: Extracellular vesicles (EVs) have been revealed to facilitate the development of oral squamous cavity cell carcinoma (OCSCC), while its supporting role in lymph node metastases is under continuous investigation. This study aimed to examine the function of cancer-associated fibroblasts (CAF)-derived EVs (CAF-EVs) during lymph node metastasis in OCSCC and the mechanisms. METHODS: CAF were isolated from OCSCC tissues of patients, and CAF-EVs were extracted and identified...
January 22, 2024: BMC Cancer
https://read.qxmd.com/read/38159573/renal-macrophages-monitor-and-remove-particles-from-urine-to-prevent-tubule-obstruction
#3
JOURNAL ARTICLE
Jian He, Yangyang Cao, Qian Zhu, Xinge Wang, Guo Cheng, Qiang Wang, Rukun He, Haoran Lu, Yuancheng Weng, Genxiang Mao, Yizhong Bao, Jing Wang, Xiaoli Liu, Fei Han, Peng Shi, Xiao Z Shen
When the filtrate of the glomerulus flows through the renal tubular system, various microscopic sediment particles, including mineral crystals, are generated. Dislodging these particles is critical to ensuring the free flow of filtrate, whereas failure to remove them will result in kidney stone formation and obstruction. However, the underlying mechanism for the clearance is unclear. Here, using high-resolution microscopy, we found that the juxtatubular macrophages in the renal medulla constitutively formed transepithelial protrusions and "sampled" urine contents...
January 9, 2024: Immunity
https://read.qxmd.com/read/38065955/yy1-modulates-the-radiosensitivity-of-esophageal-squamous-cell-carcinoma-through-kif3b-mediated-hippo-signaling-pathway
#4
JOURNAL ARTICLE
Chunyan Zheng, Zhe Li, Chuanxi Zhao, Xiaoyang Yin, Lei Feng, Zhongtang Wang, Chengxin Liu, Baosheng Li
Radiotherapy is an important strategy in the comprehensive treatment of esophageal squamous cell carcinoma (ESCC). However, effectiveness of radiotherapy is still restricted by radioresistance. Herein, we aimed to understand the mechanisms underlying ESCC radioresistance, for which we looked into the potential role of YY1. YY1 was upregulated in radioresistant tissues and correlated with poor prognosis of patients with ESCC. YY1 depletion enhanced the radiosensitivity of ESCC in vitro and in vivo. Multi-group sequencing showed that downregulation of YY1 inhibited the transcriptional activity of Kinesin Family Member 3B (KIF3B), which further activated the Hippo signaling pathway by interacting with Integrin-beta1 (ITGB1)...
December 8, 2023: Cell Death & Disease
https://read.qxmd.com/read/37907465/decreased-b4galt1-promotes-hepatocellular-carcinoma-cell-invasiveness-by-regulating-the-laminin-integrin-pathway
#5
JOURNAL ARTICLE
Po-Da Chen, Ying-Yu Liao, Yu-Chia Cheng, Hsin-Yi Wu, Yao-Ming Wu, Min-Chuan Huang
Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expressed in the liver, and patients with mutations in B4GALT1 exhibit hepatopathy. However, the role of B4GALT1 in liver cancer remains unclear. Here, we found that B4GALT1 was significantly downregulated in hepatocellular carcinoma (HCC) tissue compared with the adjacent liver tissue, and low B4GALT1 expression was associated with vascular invasion and poor overall survival in patients with HCC...
October 31, 2023: Oncogenesis
https://read.qxmd.com/read/37855260/integrin-beta1-mediates-the-effect-of-telocytes-on-mesenchymal-stem-cell-proliferation-and-migration-in-the-treatment-of-acute-lung-injury
#6
JOURNAL ARTICLE
Ruixue Qi, Jiayun Hou, Ying Yang, Zhicheng Yang, Lihong Wu, Tiankui Qiao, Xiangdong Wang, Dongli Song
Co-transplantation of mesenchymal stem cells (MSCs) with telocytes (TCs) was found to have therapeutic effects, although the mechanism of intercellular communication is still unknown. Our current studies aim at exploring the potential molecular mechanisms of TCs interaction and communication with MSCs with a focus on integrin beta1 (ITGB1) in TCs. We found that the co-culture of MSCs with ITGB1-deleted TCs (TCITGB1-ko ) changed the proliferation, differentiation and growth dynamics ability of MSC in responses to LPS or PI3K inhibitor...
October 19, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37427767/pfkfb3-downregulation-aggravates-angiotensin-ii-induced-podocyte-detachment
#7
JOURNAL ARTICLE
Xiaoxiao Huang, Zhaowei Chen, Zilv Luo, Yiqun Hao, Jun Feng, Zijing Zhu, Xueyan Yang, Zongwei Zhang, Jijia Hu, Wei Liang, Guohua Ding
Podocytes play a critical role in maintaining normal glomerular filtration, and podocyte loss from the glomerular basement membrane (GBM) initiates and worsens chronic kidney disease (CKD). However, the exact mechanism underlying podocyte loss remains unclear. Fructose-2,6-biphosphatase 3 (PFKFB3) is a bifunctional enzyme that plays crucial roles in glycolysis, cell proliferation, cell survival, and cell adhesion. This study aimed to determine the role of PFKFB3 in angiotensin II (Ang II) kidney damage. We found that mice infused with Ang II developed glomerular podocyte detachment and impaired renal function accompanied by decreased PFKFB3 expression in vivo and in vitro ...
December 2023: Renal Failure
https://read.qxmd.com/read/37306667/a-new-graphene-based-nanomaterial-increases-lipolysis-and-reduces-body-weight-gain-through-integrin-linked-kinase-ilk
#8
JOURNAL ARTICLE
Sergio de Frutos, Mercedes Griera, Maria Del Prado Lavín-López, Martín Martínez-Rovira, José António Martínez-Rovira, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol
UNLABELLED: White adipose tissue (WAT) hypertrophy is caused by the excessive storage of triglycerides (TGs) and is associated with obesity. We previously demonstrated that extracellular matrix mediator integrin beta1 (INTB1) and its downstream effector integrin linked kinase (ILK) are implicated in obesity establishment. We also considered in our previous works that ILK upregulation is a therapeutical strategy to reduce WAT hypertrophy. Carbon based nanomaterials (CNMs) have interesting potential to modify cell differentiation but have been never studied to change the properties of adipocytes...
June 12, 2023: Biomaterials Science
https://read.qxmd.com/read/36456612/integrin-beta1-itgb1-as-a-prognostic-marker-in-esophageal-adenocarcinoma
#9
JOURNAL ARTICLE
Alexander I Damanakis, Isabell Wahler, Hans Fuchs, Heike Löser, Wolfgang Schröder, Thomas Zander, Seung-Hun Chon, Christiane Bruns, Alexander Quaas, Florian Gebauer
Today, individual prognosis in patients with adenocarcinoma of the esophagus (EAC) is based on post-surgical TNM staging and valid biomarkers are still not implemented. Integrin beta1 (ITGB1) is widely expressed in epithelial cells and promotes cell adhesion and growth. Its impact on tumor progression was described for different tumor entities before, data on its function as a potential biomarker in EAC is not available. Aim of the study is to evaluate the expression level of ITGB1 in a large collective of EAC and its impact on patients´ prognosis...
December 1, 2022: Scientific Reports
https://read.qxmd.com/read/36430291/fertilization-but-not-post-implantation-development-can-occur-in-the-absence-of-sperm-and-oocyte-beta1-integrin-in-mice
#10
JOURNAL ARTICLE
Nour El Houda Mimouni, Côme Ialy-Radio, Anne-Lyse Denizot, Isabelle Lagoutte, Michaela Frolikova, Katerina Komrskova, Sandrine Barbaux, Ahmed Ziyyat
Fertilization is a complex process that requires successive stages and culminates in the adhesion/fusion of gamete membranes. If the question of the involvement of oocyte integrins has been swept away by deletion experiments, that of the involvement of sperm integrins remains to be further characterized. In the present study, we addressed the question of the feasibility of sperm-oocyte adhesion/fusion and early implantation in the absence of sperm β1 integrin. Males and females with β1 integrin-depleted sperm and oocytes were mated, and fertilization outcome was monitored by a gestational ultrasound analysis...
November 9, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36266942/discoidin-domain-receptor-1-regulates-erbb2-erbb3-signaling-in-mammary-epithelial-cells
#11
JOURNAL ARTICLE
Andrés Martin Toscani, Pablo Aguilera, Federico Coluccio Leskow
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels...
November 2022: FEBS Letters
https://read.qxmd.com/read/36259480/granulosa-cell-conditioned-medium-enhances-the-rate-of-mouse-oocyte-in-vitro-maturation-and-embryo-formation
#12
JOURNAL ARTICLE
Zeinab Bahrami, Narges Hatamian, Mahmood Talkhabi, Elnaz Zand, David G Mottershead, Rouhollah Fathi
OBJECTIVE: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes using granulosa cell conditioned medium (GCCM). MATERIALS AND METHODS: In the experimental study, fresh/non-vitrified and vitrified-warmed mouse germinal vesicle (GV) oocytes (as F and V) were In vitro maturated using basal medium (BM) and also BM supplemented with 50% GCCM as treated groups (GM), and categorized as FBM, FGM, VBM and VGM groups, respectively...
October 1, 2022: Cell Journal
https://read.qxmd.com/read/36254341/determining-biomarkers-for-evaluation-and-diagnosis-of-hereditary-angioedema
#13
JOURNAL ARTICLE
Umesh Singh, Jonathan A Bernstein
Rationale: Kallikrein-bradykinin-forming cascade is known to cause hereditary angioedema (HAE) acute angioedema (AE) attacks. Further research of HAE attacks is needed to explain disease heterogeneity, predict treatment response and identify biomarkers for monitoring HAE attacks. Differential expression of the microvascular endothelial cell-surface receptors for example, g-C1qR, cytokeratin-1, and plasminogen-activator-urokinase-receptor (PLAUR) were hypothesized as biomarkers of AE attacks...
October 2022: Clinical and Translational Allergy
https://read.qxmd.com/read/36093403/gastrocnemius-muscle-injury-is-the-condition-to-induce-cartilage-degeneration-of-the-rabbit-tibiofemoral-joint-a-new-perspective
#14
JOURNAL ARTICLE
Yuanyuan Li, Jiwei Sun, Yimin Hou, Jiabi Wei, Yuzhuo Chai, Xiangyu Zhu, Rongguo Wang
The knee osteoarthritis is a common joint disease that causes pain and inconvenience. Clinically, patients with knee osteoarthritis often have response points on the gastrocnemius. Gastrocnemius plays an essential role in stabilizing joints and changing gait and pace, which also has a close relationship with the knee joint. The objective of this study is to determine changes in the tibiofemoral joint after medial and lateral gastrocnemius injury. Rabbits were divided into a medial gastrocnemius injury group, a lateral gastrocnemius injury group, and a control group with two intervals: 6 and 8 weeks after modeling of the semisevered gastrocnemius...
2022: BioMed Research International
https://read.qxmd.com/read/35883678/integrin-signaling-shaping-btk-inhibitor-resistance
#15
REVIEW
Laura Polcik, Svenja Dannewitz Prosseda, Federico Pozzo, Antonella Zucchetto, Valter Gattei, Tanja Nicole Hartmann
Integrins are adhesion molecules that function as anchors in retaining tumor cells in supportive tissues and facilitating metastasis. Beta1 integrins are known to contribute to cell adhesion-mediated drug resistance in cancer. Very late antigen-4 (VLA-4), a CD49d/CD29 heterodimer, is a beta1 integrin implicated in therapy resistance in both solid tumors and haematological malignancies such as chronic lymphocytic leukemia (CLL). A complex inside-out signaling mechanism activates VLA-4, which might include several therapeutic targets for CLL...
July 18, 2022: Cells
https://read.qxmd.com/read/35835371/genome-wide-crispr-screen-identified-a-role-for-commander-complex-mediated-itgb1-recycling-in-basal-insulin-secretion
#16
JOURNAL ARTICLE
Liu Yang, Margret A Fye, Bingyuan Yang, Zihan Tang, Yue Zhang, Sander Haigh, Brittney A Covington, Kai Bracey, Justin W Taraska, Irina Kaverina, Shen Qu, Wenbiao Chen
OBJECTIVES: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here, we performed a genome-wide CRISPR/Cas9 knockout screen to identify novel regulators of insulin secretion. METHODS: To identify genes that cell autonomously regulate insulin secretion, we engineered a Cas9-expressing MIN6 subclone that permits irreversible fluorescence labeling of exocytic insulin granules...
September 2022: Molecular Metabolism
https://read.qxmd.com/read/35763345/ligand-independent-integrin-%C3%AE-1-signaling-supports-lung-adenocarcinoma-development
#17
JOURNAL ARTICLE
Scott M Haake, Erin J Plosa, Jonathan A Kropski, Lindsay A Venton, Anupama Reddy, Fabian Bock, Betty T Chang, Allen J Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V Polosukhin, Olga M Viquez, Angela Jones, Wentian Luo, Matthew H Wilson, W Kimryn Rathmell, Pierre P Massion, Ambra Pozzi, Timothy S Blackwell, Roy Zent
Integrins - the principal extracellular matrix (ECM) receptors of the cell - promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer therapeutics have disrupted integrin-ECM interactions, which are viewed as critical for integrin functions. However, such agents have failed to improve cancer patient outcomes. We show that the highly expressed integrin β1 subunit is required for lung adenocarcinoma development in a carcinogen-induced mouse model...
August 8, 2022: JCI Insight
https://read.qxmd.com/read/35729564/exosomes-from-human-induced-pluripotent-stem-cells-derived-keratinocytes-accelerate-burn-wound-healing-through-mir-762-mediated-promotion-of-keratinocytes-and-endothelial-cells-migration
#18
JOURNAL ARTICLE
Yunyao Bo, Lijun Yang, Baiting Liu, Guiping Tian, Chenxi Li, Lin Zhang, Yuan Yan
BACKGROUND: The use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn treatment. There is growing evidence that extracellular vesicles, including exosomes, are primary mediators of the benefits of stem cell therapy. Herein, we thus explored the effects of exosomes produced by iPSCs-derived keratinocytes (iPSCs-KCs-Exos) in a model of deep second-degree burn wound healing and evaluated the mechanistic basis for the observed activity...
June 21, 2022: Journal of Nanobiotechnology
https://read.qxmd.com/read/35538304/presence-of-bone-marrow-fibrosis-in-multiple-myeloma-may-predict-extramedullary-disease
#19
JOURNAL ARTICLE
Megumi Koshiishi, Ichiro Kawashima, Hideto Hyuga, Ayato Nakadate, Minori Matsuura, Eriko Hosokawa, Yuma Sakamoto, Jun Suzuki, Megumi Suzuki, Takuma Kumagai, Takeo Yamamoto, Kei Nakajima, Masaru Tanaka, Keita Kirito
We analyzed the incidence of bone marrow fibrosis in 91 newly diagnosed Japanese multiple myeloma (MM) patients and evaluated the impact of fibrosis on clinical characteristics and therapeutic outcomes. Thirty-four (37%) patients had greater than grade 1 bone marrow fibrosis. The presence of bone marrow fibrosis did not affect laboratory data, the percentage of plasma cells in bone marrow or cytogenetic findings. It also had no significant effect on response to initial treatment, engraftment after autologous hematopoietic stem cell transplantation or overall survival...
May 10, 2022: International Journal of Hematology
https://read.qxmd.com/read/35381120/laptm4b-35-promotes-cancer-cell-migration-via-stimulating-integrin-beta1-recycling-and-focal-adhesion-dynamics
#20
JOURNAL ARTICLE
Minxia Liu, Ruyu Yan, Junjie Wang, Zhihong Yao, Xinyu Fan, Kecheng Zhou
Metastasis is the main cause of cancer patients' death despite tremendous efforts invested in developing the related molecular mechanisms. During cancer cell migration, cells undergo dynamic regulation of filopodia, focal adhesion, and endosome trafficking. Cdc42 is imperative for maintaining cell morphology and filopodia, regulating cell movement. Integrin beta1 activates on the endosome, the majority of which distributes itself on the plasma membrane, indicating that endocytic trafficking is essential for this activity...
April 5, 2022: Cancer Science
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