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integrin beta1

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https://www.readbyqxmd.com/read/28660189/eosinophil-activation-status-in-separate-compartments-and-association-with-asthma
#1
REVIEW
Mats W Johansson
Asthma is frequently characterized by eosinophil-rich airway inflammation. Airway eosinophilia is associated with asthma exacerbations and likely plays a part in airway remodeling. Eosinophil recruitment from the bloodstream depends on circulating eosinophils becoming activated, which leads to eosinophil arrest on activated endothelium, extravasation, and continued movement through the bronchial tissue by interaction with the extracellular matrix (ECM). Circulating eosinophils can exist at different activation levels, which include non-activated or pre-activated (sensitized or "primed")...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28613134/elevation-of-mir-9-3p-suppresses-the-epithelial-mesenchymal-transition-of-nasopharyngeal-carcinoma-cells-via-down-regulating-fn1-itgb1-and-itgav
#2
Yu Ding, Yinghua Pan, Shan Liu, Feng Jiang, Junbo Jiao
MicroRNAs had been proved to be pivotal regulators in nasopharyngeal carcinoma (NPC) by regulating a large amount of genes' expression. In our research, we aim to explore the functions of miR-9-3p on the metastases of NPC and figure out the potential mechanisms. First, we revealed downregulation of miR-9-3p and upregulation of fibronectin 1 (FN1), β1 integrin (ITGB1) and α5 integrin (ITGAV) expression in NPC tissues and cells compared with the normal using RNA-seq analysis, RT-qPCR, western blot and immunohistochemistry...
June 14, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28578803/head-and-neck-cancer-cell-radiosensitization-upon-dual-targeting-of-c-abl-and-beta1-integrin
#3
Philipp Koppenhagen, Ellen Dickreuter, Nils Cordes
Integrin-mediated cell adhesion to extracellular matrix (ECM) critically contributes to cancer cell therapy resistance and DNA double strand break (DSB) repair. c-Abl tyrosine kinase has been linked to both of these processes. Based on our previous findings indicating c-Abl hyperphosphorylation on tyrosine (Y) 412 and threonine (T) 735 upon beta1-integrin inhibition, we hypothesized c-Abl tyrosine kinase as an important mediator of beta1-integrin signaling for radioresistance. In a panel of 8 cell lines from different solid cancer types grown in 3D laminin-rich ECM cultures, we targeted beta1 integrin with AIIB2 (mAb) and c-Abl with Imatinib with and without X-ray irradiation and subsequently examined clonogenic survival, residual DSBs, protein expression and phosphorylation...
May 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28306722/distinct-erbb2-receptor-populations-differentially-interact-with-beta1-integrin-in-breast-cancer-cell-models
#4
Andrés Martín Toscani, Rocío G Sampayo, Federico Martín Barabas, Federico Fuentes, Marina Simian, Federico Coluccio Leskow
ErbB2 is a member of the ErbB family of tyrosine kinase receptors that plays a major role in breast cancer progression. Located at the plasma membrane, ErbB2 forms large clusters in spite of the presence of growth factors. Beta1 integrin, membrane receptor of extracellular matrix proteins, regulates adhesion, migration and invasiveness of breast cancer cells. Physical interaction between beta1 integrin and ErbB2 has been suggested although published data are contradictory. The aim of the present work was to study the interaction between ErbB2 and beta1 integrin in different scenarios of expression and activation...
2017: PloS One
https://www.readbyqxmd.com/read/28237246/sipa1-promotes-invasion-and-migration-in-human-oral-squamous-cell-carcinoma-by-itgb1-and-mmp7
#5
Toshikazu Takahara, Atsushi Kasamatsu, Masanobu Yamatoji, Manabu Iyoda, Hiroki Kasama, Tomoaki Saito, Shin Takeuchi, Yosuke Endo-Sakamoto, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Signal-induced proliferation-associated protein 1 (SIPA1) is known to be a GTPase activating protein. Overexpressed SIPA1 is related to metastatic progression in breast and prostate cancers; however, the relevance of SIPA1 in oral squamous cell carcinoma (OSCC) is still unknown. The aim of this study was to examine SIPA1 expression and its functional mechanisms in OSCC. SIPA1 mRNA and protein expressions were analyzed by quantitative reverse transcriptase-polymerase chain reaction, Western blot analysis, and immunohistochemistry...
March 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28222496/the-integrins-involved-in-soybean-agglutinin-induced-cell-cycle-alterations-in-ipec-j2
#6
Li Pan, Yuan Zhao, Zhijie Yuan, Mohammed Hamdy Farouk, Shiyao Zhang, Nan Bao, Guixin Qin
Soybean agglutinin (SBA) is an anti-nutritional factor of soybean, affecting cell proliferation and inducing cytotoxicity. Integrins are transmembrane receptors, mediating a variety of cell biological processes. This research aims to study the effects of SBA on cell proliferation and cell cycle progression of the intestinal epithelial cell line from piglets (IPEC-J2), to identify the integrin subunits especially expressed in IPEC-J2s, and to analyze the functions of these integrins on IPEC-J2 cell cycle progression and SBA-induced IPEC-J2 cell cycle alteration...
February 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28214208/reduced-immunohistochemical-expression-of-adhesion-molecules-in-vitiligo-skin-biopsies
#7
Adriane Reichert Faria, Juliana Elizabeth Jung, Caio César Silva de Castro, Lucia de Noronha
Because defects in adhesion impairment seem to be involved in the etiopathogenesis of vitiligo, this study aimed to compare the immunohistochemical expression of several adhesion molecules in the epidermis of vitiligo and non lesional vitiligo skin. Sixty-six specimens of lesional and non lesional skin from 33 volunteers with vitiligo were evaluated by immunohistochemistry using anti-beta-catenin, anti-E-cadherin, anti-laminin, anti-beta1 integrin, anti-collagen IV, anti-ICAM-1 and anti-VCAM-1 antibodies. Biopsies of vitiligo skin demonstrated a significant reduction in the expression of laminin and integrin...
March 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28154321/new-type-of-antitumor-agent-targeting-the-cell-adhesion-molecule-integrin
#8
REVIEW
Fumio Fukai
 The extracellular matrix (ECM) provides a variety of biological signals for cell regulation. It is apparent that some of these signals are derived from functional sites, which are concealed in the higher structure of ECM protein molecules. Previously, we found that fibronectin, a ubiquitous cell adhesive ECM protein, harbors a cryptic functional site termed FNIII14, which can be exposed through the processing of fibronectin by inflammatory proteinases, including matrix metalloproteinase-2 (MMP-2). FNIII14, once exposed, induces a conformational change in beta1-integrins necessary for their functional inactivation, resulting in weakened cell adhesion to the ECM...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27997897/plasma-gelsolin-promotes-proliferation-of-mesangial-cell-in-iga-nephropathy
#9
Lei Zhang, Dan Kong, Hongxue Meng, Changsong Han, Jiang Zhu, Juanjuan Qiao, Yan He, Tianzhen Wang, Xiaobo Li, Fengmin Zhang, Xiaoming Jin
BACKGROUND/AIMS: Plasma gelsolin (pGSN) is an actin-binding protein that plays a critical role in the pathogenesis of rheumatoid arthritis. However, whether pGSN is involved in other immunological diseases remains unknown. This study focused on the relationship between pGSN and immunoglobulin A (IgA) nephropathy (IgAN). METHODS: Two hundred patients with IgAN, 200 patients each with several other types of nephropathy and healthy controls (HCs) who underwent kidney biopsies between 2000 and 2014 were enrolled in the study...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27933291/endocytosis-and-physiology-insights-from-disabled-2-deficient-mice
#10
REVIEW
Wensi Tao, Robert Moore, Elizabeth R Smith, Xiang-Xi Xu
Disabled-2 (Dab2) is a clathrin and cargo binding endocytic adaptor protein, and cell biology studies revealed that Dab2 plays a role in cellular trafficking of a number of transmembrane receptors and signaling proteins. A PTB/PID domain located in the N-terminus of Dab2 binds the NPXY motif(s) present at the cytoplasmic tails of certain transmembrane proteins/receptors. The membrane receptors reported to bind directly to Dab2 include LDL receptor and its family members LRP1 and LRP2 (megalin), growth factor receptors EGFR and FGFR, and the cell adhesion receptor beta1 integrin...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27896223/urokinase-type-plasminogen-activator-receptor-upar-as-a-new-therapeutic-target-in-cancer
#11
Nunzia Montuori, Ada Pesapane, Francesca W Rossi, Valentina Giudice, Amato De Paulis, Carmine Selleri, Pia Ragno
The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPI-anchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. uPAR also regulates cell adhesion, migration and proliferation, protects from apoptosis and contributes to epithelial mesenchymal transition (EMT), independently of uPA enzymatic activity. Indeed, uPAR interacts with beta1, beta2 and beta3 integrins, thus regulating their activities. uPAR cross-talks with receptor tyrosine kinases through integrins and regulates cancer cell dormancy, proliferation and angiogenesis...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27713116/prostate-specific-membrane-antigen-psma-assembles-a-macromolecular-complex-regulating-growth-and-survival-of-prostate-cancer-cells-in-vitro-and-correlating-with-progression-in-vivo
#12
Maria Elisa Perico, Silvia Grasso, Matteo Brunelli, Guido Martignoni, Enrico Munari, Enrico Moiso, Giulio Fracasso, Tiziana Cestari, Hassan Y Naim, Vincenzo Bronte, Marco Colombatti, Dunia Ramarli
The expression of Prostate Specific-Membrane Antigen (PSMA) increases in high-grade prostate carcinoma envisaging a role in growth and progression. We show here that clustering PSMA at LNCaP or PC3-PSMA cell membrane activates AKT and MAPK pathways thus promoting proliferation and survival. PSMA activity was dependent on the assembly of a macromolecular complex including filamin A, beta1 integrin, p130CAS, c-Src and EGFR. Within this complex beta1 integrin became activated thereby inducing a c-Src-dependent EGFR phosphorylation at Y1086 and Y1173 EGF-independent residues...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27307601/periostin-postn-regulates-tumor-resistance-to-antiangiogenic-therapy-in-glioma-models
#13
Soon Young Park, Yuji Piao, Kang Jin Jeong, Jianwen Dong, John F de Groot
Periostin (POSTN) interacts with multiple integrins to coordinate a variety of cellular processes, including epithelial-to-mesenchymal transition (EMT) and cell migration. In our previous study, anti-VEGF-A therapy was associated with resistance and EMT. This study sought to determine the role of POSTN in the resistance of glioma stem cells (GSC) to antiangiogenic therapy. In mouse xenograft models of human glioma, POSTN expression was associated with acquired resistance to anti-VEGF-A therapy and had a synergistic effect with bevacizumab in prolonging survival and decreasing tumor volume...
September 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27276823/-phenotypic-changes-of-epidermal-stem-cells-differentiating-into-sweat-glands-cells-in-vitro-and-its-mechanism
#14
Fuhuan Chen, Xiaotong Yue, Huifeng Song, Jiake Chai, Xiuye He, Tongmin Wang, Lingying Liu
OBJECTIVE: To explore the phenotypic changes of epidermal stem cells (ESCs) differentiating into sweat glands cells (SGCs) in vitro and its mechanisms. METHODS: ESCs and SGCs were isolated and cultured in vitro, which were identified using immunofluorescence staining. ESCs at passage 2 were divided into 4 groups: ESCs and SGCs co-cultured by Transwell plates in group A, ESCs cultured by simply adding sweat supernatant in group B, ESCs and SGCs co-cultured on Transwell plate adding epidermal growth factor (EGF) (60 ng/mL) in group C, and ESCs and SGCs co-cultured on transwell plate adding PD98059 (10 mmol/L) in group D...
February 2016: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/27259249/extracellular-matrix-specific-caveolin-1-phosphorylation-on-tyrosine-14-is-linked-to-augmented-melanoma-metastasis-but-not-tumorigenesis
#15
Rina Ortiz, Jorge Díaz, Natalia Díaz, Lorena Lobos-Gonzalez, Areli Cárdenas, Pamela Contreras, María Inés Díaz, Ellen Otte, Justin Cooper-White, Vicente Torres, Lisette Leyton, Andrew F G Quest
Caveolin-1 (CAV1) is a scaffolding protein that plays a dual role in cancer. In advanced stages of this disease, CAV1 expression in tumor cells is associated with enhanced metastatic potential, while, at earlier stages, CAV1 functions as a tumor suppressor. We recently implicated CAV1 phosphorylation on tyrosine 14 (Y14) in CAV1-enhanced cell migration. However, the contribution of this modification to the dual role of CAV1 in cancer remained unexplored. Here, we used in vitro [2D and transendothelial cell migration (TEM), invasion] and in vivo (metastasis) assays, as well as genetic and biochemical approaches to address this question in B16F10 murine melanoma cells...
June 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27076857/silencing-of-herg1-gene-inhibits-proliferation-and-invasion-and-induces-apoptosis-in-human-osteosarcoma-cells-by-targeting-the-nf-%C3%AE%C2%BAb-pathway
#16
Wenrong Zeng, Qingjun Liu, Zhida Chen, Xinyu Wu, Yuanfu Zhong, Jin Wu
Recently, the human ether à go-go (eag) related gene 1 (hERG1) channel, a member of the voltage-dependent potassium channel (Kv) family, was determined to have a critical role in cancer cell proliferation, invasion, tumorigenesis and apoptosis. However, the expression levels and functions of hERG1 in osteosarcoma cells remain poorly characterized. In this study, hERG1 transcript and protein levels in osteosarcoma cells and tissues were measured using semi-quantitative real time PCR (RT-PCR), Western blot, and immunohistochemistry...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27076856/efficacy-of-beta1-integrin-and-egfr-targeting-in-sphere-forming-human-head-and-neck-cancer-cells
#17
Katja Zscheppang, Ina Kurth, Nicole Wachtel, Anna Dubrovska, Leoni A Kunz-Schughart, Nils Cordes
BACKGROUND: Resistance to radiotherapy continues to be a limiting factor in the treatment of cancer including head and neck squamous cell carcinoma (HNSCC). Simultaneous targeting of β1 integrin and EGFR was shown to have a higher radiosensitizing potential than mono-targeting in the majority of tested HNSCC cancer models. As tumor-initiating cells (TIC) are thought to play a key role for therapy resistance and recurrence and can be enriched in sphere forming conditions, this study investigated the efficacy of β1 integrin/EGFR targeting without and in combination with X-ray irradiation on the behavior of sphere-forming cells (SFC)...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/26969500/the-effect-of-different-collagen-modifications-for-titanium-and-titanium-nitrite-surfaces-on-functions-of-gingival-fibroblasts
#18
U Ritz, T Nusselt, A Sewing, T Ziebart, K Kaufmann, A Baranowski, P M Rommens, Alexander Hofmann
OBJECTIVES: Targeted modifications of the bulk implant surfaces using bioactive agents provide a promising tool for improvement of the long-term bony and soft tissue integration of dental implants. In this study, we assessed the cellular responses of primary human gingival fibroblasts (HGF) to different surface modifications of titanium (Ti) and titanium nitride (TiN) alloys with type I collagen or cyclic-RGDfK-peptide in order to define a modification improving long-term implants in dental medicine...
January 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/26955273/the-potential-applications-of-fibrin-coated-electrospun-polylactide-nanofibers-in-skin-tissue-engineering
#19
Marketa Bacakova, Jana Musilkova, Tomas Riedel, Denisa Stranska, Eduard Brynda, Margit Zaloudkova, Lucie Bacakova
Fibrin plays an important role during wound healing and skin regeneration. It is often applied in clinical practice for treatment of skin injuries or as a component of skin substitutes. We prepared electrospun nanofibrous membranes made from poly(l-lactide) modified with a thin fibrin nanocoating. Fibrin surrounded the individual fibers in the membrane and also formed a thin fibrous mesh on several places on the membrane surface. The cell-free fibrin nanocoating remained stable in the cell culture medium for 14 days and did not change its morphology...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/26675717/gene-expression-profiling-combined-with-functional-analysis-identify-integrin-beta1-itgb1-as-a-potential-prognosis-biomarker-in-triple-negative-breast-cancer
#20
Sukhontip Klahan, Wan-Chen Huang, Che-Mai Chang, Henry Sung-Ching Wong, Chi-Cheng Huang, Mei-Shin Wu, Yu-Chiao Lin, Hsing-Fang Lu, Ming-Feng Hou, Wei-Chiao Chang
Triple negative breast cancer (TNBC) accounts for approximately 15-20% of all types of breast cancer, and treatment is still limited. This type of breast cancer shows a high risk of recurrence, visceral metastasis, a worse prognosis, and shorter distant metastasis-free survival. Several studies have been reported that genetics factors are associated with breast cancer disease progression and patients' survival. In this study, we combined Taiwanese microarray data from the GEO database and The Cancer Genome Atlas (TCGA) database to study the role of Integrin Beta1 (ITGB1) in TNBC...
February 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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