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https://www.readbyqxmd.com/read/29774782/the-neuroprotective-effect-of-ethanol-intoxication-in-tbi-is-associated-with-the-suppression-of-erbb-signaling-in-pv-positive-interneurons
#1
Akila Chandrasekar, Florian Olde Heuvel, Martin Wepler, Rida Rehman, Annette Palmer, Alberto Catanese, Birgit Linkus, Albert Ludolph, Tobias Boeckers, Markus Huber-Lang, Peter Radermacher, Francesco Roselli
Ethanol intoxication (EI) is a frequent comorbidity of TBI, but the impact of EI on TBI pathogenic cascades and prognosis is unclear: although clinical evidence suggests that EI may have neuroprotective effects, experimental support is, to date, inconclusive. We aimed at elucidating the impact of EI on TBI-associated neurological deficits, signaling pathways and pathogenic cascades, in order to identify new modifiers of TBI pathophysiology. We have shown that ethanol administration (5g/Kg) before trauma enhances behavioral recovery in a weight-drop TBI model; neuronal survival in the injured somatosensory cortex was enhanced by EI...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29760222/erk-mutations-and-amplification-confer-resistance-to-erk-inhibitor-therapy
#2
Bijay S Jaiswal, Steffen Durinck, Eric Stawiski, Jianping Yin, Weiru Wang, Eva Lin, John G Moffat, Scott Martin, Zora Modrusan, Somasekar Seshagiri
PURPOSE: MAPK pathway inhibitors targeting BRAF and MEK have shown clinical efficacy in patients with RAF and/or RAS mutated tumors. However, acquired resistance to these agents has been an impediment to improved long-term survival in the clinic. In such cases, targeting ERK downstream of BRAF/MEK has been proposed as a potential strategy for overcoming acquired resistance. Preclinical studies suggest that ERK inhibitors are effective at inhibiting BRAF/RAS mutated tumor growth and overcome BRAF or/and MEK inhibitor resistance...
May 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29743681/poziotinib-for-uncommon-erbb-mutations
#3
Diana Romero
No abstract text is available yet for this article.
May 9, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29740279/activation-of-neuregulin-1-erbb-signaling-is-involved-in-the-development-of-tocp-induced-delayed-neuropathy
#4
Hai-Yang Xu, Pan Wang, Ying-Jian Sun, Ming-Yuan Xu, Li Zhu, Yi-Jun Wu
Organophosphate-induced delayed neuropathy (OPIDN) is characterized by progressive axonal degeneration and demyelination of the spinal cord and sciatic nerves. The neuregulin 1/epidermal growth factor receptor (ErbB) signaling pathway is crucial for axonal myelination. In this study, we investigated whether the neuregulin 1/ErbB signaling pathway mediated the progression of OPIDN. Adult hens were given tri- o -cresyl phosphate (TOCP), a typical neuropathic organophosphorus compound, to induce OPIDN. The ErbB inhibitor lapatinib was administered to hens 4 h prior to and 4 days after TOCP exposure...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29731976/predicting-high-risk-endometrioid-carcinomas-using-proteins
#5
Di Du, Wencai Ma, Melinda S Yates, Tao Chen, Karen H Lu, Yiling Lu, John N Weinstein, Russell R Broaddus, Gordon B Mills, Yuexin Liu
Background: The lethality of endometrioid endometrial cancer (EEC) is primarily attributable to advanced-stage diseases. We sought to develop a biomarker model that predicts EEC surgical stage at the time of clinical diagnosis. Results: PSES was significantly correlated with surgical stage in the TCGA cohort ( P < 0.0001) and in the validation cohort ( P = 0.0003). Even among grade 1 or 2 tumors, PSES was significantly higher in advanced than in early stage tumors in both the TCGA ( P = 0...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29725243/mirna-135b-contributes-to-triple-negative-breast-cancer-molecular-heterogeneity-different-expression-profile-in-basal-like-versus-non-basal-like-phenotypes
#6
Paolo Uva, Paolo Cossu-Rocca, Federica Loi, Giovanna Pira, Luciano Murgia, Sandra Orrù, Matteo Floris, Maria Rosaria Muroni, Francesca Sanges, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
The clinical and genetic heterogeneity of Triple Negative Breast Cancer (TNBC) and the lack of unambiguous molecular targets contribute to the inadequacy of current therapeutic options for these variants. MicroRNAs (miRNA) are a class of small highly conserved regulatory endogenous non-coding RNA, which can alter the expression of genes encoding proteins and may play a role in the dysregulation of cellular pathways. Our goal was to improve the knowledge of the molecular pathogenesis of TNBC subgroups analyzing the miRNA expression profile, and to identify new prognostic and predictive biomarkers...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29721046/association-between-the-snps-of-the-tob1-gene-and-gastric-cancer-risk-in-the-chinese-han-population-of-northeast-china
#7
Hui Wang, Huiting Hao, Haonan Guo, Yuanyuan Wang, Xuelong Zhang, Lidan Xu, Jingcui Yu
The TOB1 (ErbB-2,1) gene is an anti-proliferative factor that has the potential to regulate cell growth and encodes a member of the transducer of erbB-2/B-cell translocation gene protein. The association between the polymorphisms of the TOB1 gene and gastric cancer (GC) risk is still unclear. In this study, 506 GC cases and 548 healthy controls (HCs) were collected to evaluate the association between the eleven SNPs (rs35220381, rs12950561, rs7221352, rs61482741, rs9303568, rs34700818, rs12949115, rs9903822, rs12601477, rs11656976 and rs4626) of the TOB1 gene and GC risk in the population of northeast China...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29705125/systematically-analyses-of-the-common-dysregulated-networks-to-understand-the-common-pathologies-between-t2d-and-atherosclerosis
#8
Zijing Lin, Fan Yang, Lijie Sun, Jie Gao, Yan Cao, Hui Qiu, Xiaorong Zhan
BACKGROUND: Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus, causes cerebro-cardiovascular diseases (CVD), which increase the risk of death in patients with DM and significantly reduce their quality of life. Therefore, mechanisms underlying the common shared pathologies between type 2 diabetes (T2D) and atherosclerosis are key to prevention and treatment of diabetic macroangiopathy. However, the common shared pathological links between T2D and atherosclerosis are not fully understood...
April 26, 2018: Gene
https://www.readbyqxmd.com/read/29696467/ocular-sebaceous-gland-carcinoma-an-update-of-the-literature
#9
REVIEW
Maria Vittoria Cicinelli, Swathi Kaliki
PURPOSE: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment. METHODS: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. RESULTS: Globally, the overall incidence of SGC is increasing making it the third most common eyelid malignancy after basal cell carcinoma (BCC) and squamous cell carcinoma...
April 25, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29685880/integrative-kinome-profiling-identifies-mtorc1-2-inhibition-as-treatment-strategy-in-ovarian-clear-cell-carcinoma
#10
Joseph J Caumanns, Katrien Berns, G Bea A Wisman, Rudolf S N Fehrmann, Tushar Tomar, Harry Klip, Gert Jan Meersma, E Marielle Hijmans, Annemiek Gennissen, Evelien W Duiker, Desiree Weening, Hiroaki Itamochi, Roelof Jc Kluin, An K L Reyners, Michael J Birrer, Helga B Salvesen, Ignace Vergote, Els Van Nieuwenhuysen, James D Brenton, Elena I Braicu, Jolanta Kupryjanczyk, Beata Spiewankiewicz, Lorenza Mittempergher, Rene Bernards, Ate G J van der Zee, Steven de Jong
PURPOSE: Advanced stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor ARID1A and activating mutations in the PI3K subunit PIK3CA. In this study, we aimed to identify currently unknown mutated kinases in OCCC patients and test druggability of downstream affected pathways in OCCC models. EXPERIMENTAL DESIGN: In a large set of OCCC patients (n=124), the human kinome (518 kinases) and additional cancer related genes were sequenced and copy number alterations were determined...
April 23, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29683256/the-immunoglobulin-like-domain-of-neuregulins-potentiates-erbb3-her3-activation-and-cellular-proliferation
#11
Ariana Centa, Ruth Rodríguez-Barrueco, Juan Carlos Montero, Atanasio Pandiella
The Neuregulins (NRGs) represent a large family of membrane-anchored growth factors, whose deregulation may contribute to the pathogenesis of several tumours. In fact, targeting of NRG-activated pathways has demonstrated clinical benefit. To improve the efficacy of anti-NRG therapies, it is essential to gain insights into the regions of NRGs that favour their pro-oncogenic properties. Here we have addressed the protumorigenic impact of different NRG domains. To do this, deletion mutants affecting different NRG domains were expressed in 293 and MCF7 cells...
April 23, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29665393/comparative-experimental-theoretical-studies-on-the-egfr-dimerization-under-the-effect-of-egf-egf-analogues-binding-highlighting-the-importance-of-egf-egfr-interactions-at-site-iii-interface
#12
Masomeh Mehrabi, Hamid Mahdiuni, Hassan Rasouli, Kamran Mansouri, Mohsen Shahlaie, Reza Khodarahmi
Epidermal growth factor receptors (EGFRs) and their cytoplasmic tyrosine kinases play significant roles in cell proliferation and signaling. All the members of the EGFR/ErbB family are primary goals for cancer therapy, particularly for tumors of breast, cervix, ovaries, kidney, esophagus, prostate and non-small-cell lung carcinoma and head and neck tumors. However, the therapeutic ability of accessible anti-ErbB agents is limited. Therefore, recognizing EGF analogues or small organic molecules with high affinity for the extracellular domain of the EGFR is a critical target on cancer research...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29662620/promotion-of-malignant-phenotype-after-disruption-of-the-three-dimensional-structure-of-cultured-spheroids-from-colorectal-cancer
#13
Jose M Piulats, Jumpei Kondo, Hiroko Endo, Hiromasa Ono, Takeshi Hagihara, Hiroaki Okuyama, Yasuko Nishizawa, Yasuhiko Tomita, Masayuki Ohue, Kouki Okita, Hidejiro Oyama, Hidemasa Bono, Takashi Masuko, Masahiro Inoue
Individual and small clusters of cancer cells may detach from the edges of a main tumor and invade vessels, which can act as the origin of metastasis; however, the mechanism for this phenomenon is not well understood. Using cancer tissue-originated spheroids, we studied whether disturbing the 3D architecture of cancer spheroids can provoke the reformation process and progression of malignancy. We developed a mechanical disruption method to achieve homogenous disruption of the spheroids while maintaining cell-cell contact...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29658612/let-7d-3p-is-associated-with-apoptosis-and-response-to-neoadjuvant-chemotherapy-in-ovarian-cancer
#14
Raúl García-Vázquez, Dolores Gallardo Rincón, Erika Ruiz-García, Abelardo Meneses García, Olga N Hernández De La Cruz, Horacio Astudillo-De La Vega, David Isla-Ortiz, Laurence A Marchat, Yarely M Salinas-Vera, Ángeles Carlos-Reyes, Sullivan López-González, Rosalio Ramos-Payan, César López-Camarillo
Altered expression of microRNAs contributes to the heterogeneous biological behavior of human malignancies and it may correlate with the clinical pathological features of patients. The let-7 microRNA family is frequently downregulated in human cancers and its aberrant expression may be a useful marker for prediction of the clinical response to therapy in patients. In the present study, we analyzed the expression of three members of the let-7 family (let-7a-3p, let-7d-3p and let-7f), which remains largely uncharacterized in ovarian cancer tissues...
April 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29656750/afatinib-in-heavily-pretreated-advanced-nsclc-patients-who-progressed-following-prior-gefitinib-or-erlotinib-compassionate-use-program-in-korea
#15
Moon Ki Choi, Jin Seok Ahn, Young-Chul Kim, Byoung Chul Cho, In-Jae Oh, Sang-We Kim, Jong Seok Lee, Joo-Hang Kim, Myung-Ju Ahn, Keunchil Park
INTRODUCTION: Afatinib, an irreversible ErbB family blocker, approved for first-line treatment of epidermal growth factor receptor (EGFR) mutated advanced non-small cell lung cancer (NSCLC). This study investigated experience of afatinib within a compassionate use program (CUP). METHODS: The afatinib CUP was an open-label, multicenter, single-arm program in Korea. We enrolled patients with stage IV NSCLC and who had received at least one line of previous cytotoxic chemotherapy and previous EGFR TKI treatment with either an EGFR mutation or documented clinical benefit...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29607874/astraglaus-polysaccharide-protects-diabetic-cardiomyopathy-by-activating-nrg1-erbb-pathway
#16
Xiao Chang, Kang Lu, Ling Wang, Min Lv, Wenjun Fu
Diabetic cardiomyopathy (DCM) is one of the main cardiac complications among diabetic patients. According to previous studies, the pathogenesis of DCM is associated with oxidative stress, apoptosis and proliferation of local cardiac cells. It showed, NRG1 can improve the function of mitochondria, and thereby, increasing proliferation and decreasing apoptosis of cardiac muscle cell via ErbB/AKT signaling, also, exert antioxidative function. Besides, NRG1/ErbB pathway was impaired in the DCM model which suggested this signaling played key role in DCM...
April 2, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29602637/importin-11-overexpression-promotes-the-migration-invasion-and-progression-of-bladder-cancer-associated-with-the-deregulation-of-cdkn1a-and-thbs1
#17
Junjie Zhao, Lei Shi, Shuxiong Zeng, Chong Ma, Weidong Xu, Zhensheng Zhang, Qingzuo Liu, Peng Zhang, Yinghao Sun, Chuanliang Xu
OBJECTIVES: We recently determined that a novel oncogene, IPO11 from 5q12, participates in bladder cancer (BCa) progression. However, the biological function of IPO11 and the molecular mechanisms through which it contributes to BCa progression remain unclear. The aim of this study was to investigate the role of IPO11 in BCa aggressiveness and elucidate the molecular mechanisms underlying its effects in BCa. MATERIALS AND METHODS: The mRNA expression levels of IPO11 in BIU-87, RT4, UMUC3, EJ, 5637, T24, J82, and HT-1376 cell lines were determined using quantitative real-time polymerase chain reaction...
March 27, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29587666/cost-effectiveness-analysis-of-afatinib-versus-pemetrexed-cisplatin-for-first-line-treatment-of-locally-advanced-or-metastatic-egfr-mutation-positive-non-small-cell-lung-cancer-from-the-singapore-healthcare-payer-s-perspective
#18
Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu, Kwong Ng
BACKGROUND: Non-small-cell lung cancer (NSCLC) accounts for 85% of all lung cancers and is associated with a poor prognosis. Afatinib is an irreversible ErbB family blocker recommended in clinical guidelines as a first-line treatment for NSCLC which harbours an epidermal growth factor receptor (EGFR) mutation. The objective of this study was to evaluate the cost-effectiveness of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive NSCLC in Singapore...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29578177/the-clinical-benefit-of-epidermal-growth-factor-receptor-and-human-epidermal-growth-factor-receptor-2-targeted-agents-adding-to-endocrine-therapy-in-hormone-receptor-positive-breast-cancer
#19
Huan Li, Qing Zhai, Bo Yu
Objectives: Studies have suggested that the crosstalk between estrogen receptor and ErbB receptor is involved in endocrine therapy (ET) resistance, which might be overcome by drugs-targeting ErbB receptor. However, the results of clinical studies remain controversial. The aim of this meta-analysis was to evaluate the efficacy and safety of ErbB (mainly epidermal growth factor receptor and human epidermal growth factor receptor 2 [HER2]) inhibitors added to ET for hormone receptor-positive breast cancer patients...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29577460/gene-expression-profiling-reveals-the-plausible-mechanisms-underlying-the-antitumor-and-antimetastasis-effects-of-andrographis-paniculata-in-esophageal-cancer
#20
Lin Li, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Eric Chun-Wai Wong, Kwok-Pui Fung, Jun Yu, Clara Bik-San Lau, Philip Wai-Yan Chiu
Esophageal cancer (EC) is a seriously invasive malignancy with high mortality and poor prognosis. Metastasis of EC is the major cause of mortality. Our studies previously demonstrated that a herbal medicine Andrographis paniculata (AP) significantly suppressed EC growth and metastasis in vitro and in vivo. However, the underlying mechanisms responsible for these effects have not yet been systematically elucidated. In this context, gene expression profiling of AP-treated squamous EC cells (EC-109) was performed to reveal the regulatory mechanisms of AP in antitumor and antimetastasis signaling pathways using gene expression microarray analysis...
March 26, 2018: Phytotherapy Research: PTR
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