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brachytherapy instent

Hee Hwa Ho, On Hing Kwok, Man Hong Jim, Chung Wah Siu, Vincent Pong, Wing Hing Chow
BACKGROUND: We examined the long term clinical outcomes after administration of intravascular brachytherapy (IVBT) for instent restenosis (ISR) and de novo coronary artery lesions in percutaneous coronary intervention (PCI). METHODS AND MATERIALS: From May 2000 to August 2004, 129 symptomatic patients with ISR and de novo coronary artery lesions were treated with intravascular beta radiation after successful PCI. The primary end-point was major adverse cardiac event (MACE), i...
May 2011: Cardiovascular Revascularization Medicine: Including Molecular Interventions
P E Ruchin, D W M Muller, S C Faddy, D W Baron, P R Roy, S H Wilson
Randomised trials in a highly selected patient population have demonstrated a dramatic reduction in the incidence of in-stent restenosis (ISR) following implantation of sirolimus-eluting (S-E) Cypher coronary stents compared with bare metal stents (BMS). The clinical outcome following implantation of S-E stents for treatment of complex, unselected BMS ISR is less well defined. The aim of this study was to assess the safety and efficacy of S-E coronary stents in the treatment of an unselected population of BMS ISR...
December 2007: Heart, Lung & Circulation
Ji Hoon Shin, Ho-Young Song, Dae Hyuk Moon, Seung-Jun Oh, Jung-Sun Kim, Eun-Hee Kim, Tae-Hyung Kim, Chul-Woong Woo, Eun-Young Kim, Seong Ho Park
PURPOSE: To evaluate 20 Gy and 40 Gy of intraluminal beta-irradiation using a 188Re-7mercaptoacetyltriglycine (MAG3)-filled balloon catheter to reduce tissue hyperplasia caused by covered stent placement for 12 weeks of follow-up in a canine urethral model. MATERIAL AND METHODS: Ten dogs underwent 188Re-MAG3-filled balloon dilatation immediately after stent placement; 20 Gy at 1-mm tissue depth in group I (n = 5) and 40 Gy in group II (n = 5), whereas 5 dogs (group III) underwent conventional balloon dilatation only...
May 2006: Acta Radiologica
Kapildeo Lotun, Peter Soukas, Sung Cho, Kevin O'Donnell, André Griben, William T Irwin, Robert M Schainfeld
We describe a case of instent restenosis in a femoral-distal saphenous vein bypass graft successfully treated with brachytherapy. A 45-year-old insulin-requiring diabetic woman underwent an in-situ femoral-anterior tibial bypass graft for a non-healing ischemic ulcer. Despite a technically successful percutaneous transluminal angioplasty and endovascular stenting of a retained valve within the threatened graft, the wound failed to heal. At the 1-month follow-up, instent restenosis was documented and successful cutting balloon angioplasty, complemented by adjunctive beta-irradiation was successfully performed...
April 2005: Cardiovascular Revascularization Medicine: Including Molecular Interventions
T Pohl, C Kupatt, G Steinbeck, P Boekstegers
BACKGROUND: With the use of coronary stents for the treatment of coronary artery disease, in-stent restenosis became a major clinical problem. In this non-randomized study, we examined the use of stent-based delivery of sirolimus (rapamycin) for the treatment of in-stent restenosis in comparison to intracoronary beta-brachytherapy, regarding the clinical effectiveness and the angiographic results for the treatment of in-stent restenosis after 6-9 months. METHODS AND RESULTS: Between July 2001 and May 2002, 28 patients (65+/-11 years) with instent restenosis were treated with intracoronary brachytherapy...
June 2005: Zeitschrift Für Kardiologie
Susie Kim, Francis Q Almeda, Meechai Tessalee, R Jeffrey Snell, Sandeep Nathan, Stephen Thew, Cam Nguyen, James C H Chu, Gary L Schaer
BACKGROUND: Vascular (VBT) has clearly been shown in multiple clinical trials to decrease restenosis rates for in-stent restenosis (ISR). However, patients enrolled in these randomized clinical trials represent a select group, and the efficacy of VBT in patients with ISR who were excluded from these controlled trials due to more complex coronary anatomy requires further investigation. This study sought to define the angiographic and clinical profile and outcomes of these high-risk patients with ISR who were excluded from the randomized clinical trials and who received VBTusing Strontium-90 (Sr-90) using the Novoste Beta-Cath System through a Compassionate Use Protocol (CUP)...
January 2004: Cardiovascular Radiation Medicine
Dave C Y Chua, Francis Q Almeda, Shaun Senter, Justin Haynie, Cam Nguyen, James C H Chu, Clifford J Kavinsky, R Jeffrey Snell, Gary L Schaer
BACKGROUND: Intracoronary radiation therapy (IRT) with Sr-90 using the Novoste Beta-Cath system has been shown to be an effective therapy for instent restenosis (ISR), but the temporal occurrence of cardiac events and the predictors of late complications require further investigation. METHODS: We analyzed the demographics, lesion characteristics and clinical outcomes of 138 consecutive patients with ISR treated with IRT from September 1998 to March 2002. Major adverse cardiac events (MACE) were defined as death, myocardial infarction (MI) or target vessel revascularization (TVR)...
January 2003: Cardiovascular Radiation Medicine
B Bhargava, G S Mintz, R Mehran, A J Lansky, N J Weissman, C Walsh, R C Chan, R Waksman
We compared postintervention and follow-up intravascular ultrasound findings of 25 patients from the beta-Washington Radiation for InStent restenosis Trial (in which all patients received radiation) and 75 patients from the Washington Radiation for InStent restenosis Trial (in which patients were randomized to gamma irradiation). The decrease in lumen volume was similar for beta versus gamma and less in both gamma versus placebo and beta versus placebo; the increase in intimal hyperplasia volume was similar for beta versus gamma and greater in both beta versus placebo and gamma versus placebo...
March 1, 2000: American Journal of Cardiology
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