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Cardiac ep

Torsten Konrad, Sebastian Sonnenschein, Frank Patrick Schmidt, Hanke Mollnau, Karsten Bock, Blanca Quesada Ocete, Thomas Münzel, Cathrin Theis, Thomas Rostock
AIMS: Different cardiac arrhythmias have been suggested to be associated with Danon disease, e.g. Wolff-Parkinson-White syndrome. However, a systematic electrophysiological investigation of patients with Danon disease is lacking thus far. METHODS AND RESULTS: Seven patients with Danon disease (4 males, 35.8 ± 10.8 years; 3 females, 51.3 ± 19.9 years) from 3 different families were studied. In all patients, the presence of Danon disease was confirmed by western blot of biopsy material or genetic testing...
October 14, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Douglas Wildes, Warren Lee, Bruno Haider, Scott Cogan, Krishnakumar Sundaresan, David Mills, Christopher Yetter, Patrick Hart, Christopher Haun, Mikael Concepcion, Johan Kirkhorn, Marc Bitoun
We developed a 2.5 x 6.6 mm 2D array transducer with integrated transmit/receive ASIC for 4D ICE (real-time 3D IntraCardiac Echocardiography) applications. The ASIC and transducer design were optimized so that the high voltage transmit, low-voltage TGC (time-gain control) and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019 mm2 area of the element. The transducer assembly was deployed in a 10 Fr (3.3 mm diameter) catheter, integrated with a GE Vivid1 E9 ultrasound imaging system, and evaluated in three pre-clinical studies...
October 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Michael J Daly, Dewar D Finlay, Daniel Guldenring, Raymond R Bond, Aaron J McCann, Peter J Scott, Jennifer A Adgey, Mark T Harbinson
INTRODUCTION: Epicardial potentials (EPs) derived from the body surface potential map (BSPM) improve acute myocardial infarction (AMI) diagnosis. In this study, we compared EPs derived from the 80-lead BSPM using a standard thoracic volume conductor model (TVCM) with those derived using a patient-specific torso model (PSTM) based on body mass index (BMI). METHODS: Consecutive patients presenting to both the emergency department and pre-hospital coronary care unit between August 2009 and August 2011 with acute ischaemic-type chest pain at rest were enrolled...
September 26, 2016: European Heart Journal. Acute Cardiovascular Care
Qin Yin, Cai-Jun Wu, Jun Yang, Chen-Chen Hang, Chun-Sheng Li
OBJECTIVE: To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). METHODS: Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC)...
September 10, 2016: Chinese Journal of Integrative Medicine
Wei Gu, Qian Zhang, Chun-Sheng Li
OBJECTIVE: To investigate whether Shen-Fu Injection (, SFI) reduces post-resuscitation immune dysfunction in a porcine model of cardiac arrest by modulating apoptosis of regulatory T lymphocytes (Treg) in the spleen. METHODS: After 8-min untreated ventricular fibrillation and 2-min basic life support, 24 pigs were divided into 3 groups with a random number table, i.e. SFI group, epinephrine (EP) group, and saline (SA) group (8 in each group), which received central venous injection of SFI (1...
September 2016: Chinese Journal of Integrative Medicine
Guangrui Yang, Lihong Chen
Nonsteroidal anti-inflammatory drugs (NSAIDs), especially cyclooxygenase-2 (COX-2) selective inhibitors, are among the most widely used drugs to treat pain and inflammation. However, clinical trials have revealed that these inhibitors predisposed patients to a significantly increased cardiovascular risk, consisting of thrombosis, hypertension, myocardial infarction, heart failure, and sudden cardiac death. Thus, microsomal prostaglandin E (PGE) synthase-1 (mPGES-1), the key terminal enzyme involved in the synthesis of inflammatory prostaglandin E2 (PGE2), and the four PGE2 receptors (EP1-4) have gained much attention as alternative targets for the development of novel analgesics...
2016: Oxidative Medicine and Cellular Longevity
Jiao Lu, Shan-Shan Pan
To evaluate exercise preconditioning (EP)-induced cardioprotective effects against exercise-induced acute myocardial injury and investigate the alterations of C-type natriuretic peptide (CNP) and its specific receptor, natriuretic peptide receptor B (NPR-B), during EP-induced cardioprotection. Rats were subjected to treadmill exercise as an EP model (4 periods of 10 min each at 30 m/min with intervening periods of rest lasting 10 min). High-intensity exercise was performed 0.5 and 24 h after the EP. EP attenuated high-intensity exercise-induced myocardial injury in both the early and late phases...
August 24, 2016: Journal of Physiological Sciences: JPS
Matthias Grothoff, Matthias Gutberlet, Gerhard Hindricks, Christian Fleiter, Bernhard Schnackenburg, Steffen Weiss, Sascha Krueger, Christopher Piorkowski, Thomas Gaspar, Steve Wedan, Thomas Lloyd, Philipp Sommer, Sebastian Hilbert
OBJECTIVES: To evaluate the feasibility of performing comprehensive Cardiac Magnetic resonance (CMR) guided electrophysiological (EP) interventions in a porcine model encompassing left atrial access. METHODS: After introduction of two femoral sheaths 14 swine (41 ± 3.6 kg) were transferred to a 1.5 T MR scanner. A three-dimensional whole-heart sequence was acquired followed by segmentation and the visualization of all heart chambers using an image-guidance platform...
August 23, 2016: European Radiology
Carmen R Roberts, Joanie E Wofford, Haley M Hoy, Mitchell N Faddis
INTRODUCTION: Implantable cardioverter defibrillator (ICD) recipients who suffer from posttraumatic stress disorder (PTSD) are known to be associated with significant cardiac-specific mortality. Clinical observations suggest that PTSD is frequently undetected in ICD recipients followed up at electrophysiology (EP) outpatient clinics. Early recognition of PTSD is important to reduce the risk of serious manifestations on patient outcomes. METHODS: All ICD recipients aged 19 years or older at the Washington University School of Medicine (WASHU) EP clinic, a large urban EP clinic, were invited to participate in the project...
2016: Clinical Medicine Insights. Cardiology
Ralf-Uwe Kuehnel, Martin Hartrumpf, Michael Erb, Johannes M Albes
Objective Endovascular valve in stented biological valve implantation (valve-in-valve transcatheter aortic valve implantation [TAVI ViV]) is increasingly becoming a valid option for bioprosthesis degeneration. TAVI implantation in small stented biological valves below 23 mm is controversially discussed. Reduced opening area and high gradients are typical objections against this procedure in cases of small bioprosthesis. Systematic studies about the hemodynamic performance of endovascular valves in small stented bioprosthesis, however, do not exist...
August 12, 2016: Thoracic and Cardiovascular Surgeon
A J Ramirez, F Pessana, P Zenone, N Linale, R Sanchez
OBJECTIVE: Arterial stiffness is mainly characterized by its Peterson's Modulus (EP). Increased values of EP are associated with a reduced heart function and an increased arterial blood pressure. Assessment of EP requires simultaneous measurements of arterial diameter and pressure signals. However, instantaneous determination of arterial diameter signals implies optical and ultrasonic techniques and neither of them are portables. AIMS: To evaluate a novel method for estimating the Ep spectral variability of arterial stiffness, without arterial diameter signals...
September 2016: Journal of Hypertension
Xiaosong Gu, Jiang Xu, Liping Zhu, Timothy Bryson, Xiao-Ping Yang, Edward Peterson, Pamela Harding
BACKGROUND: Prostaglandin E2 (PGE2) EP receptors EP3 and EP4 signal via decreased and increased cAMP production, respectively. Previously, we reported that cardiomyocyte-specific EP4 knockout mice develop dilated cardiomyopathy with reduced ejection fraction. Thus, we hypothesized that PGE2 increases contractility via EP4 but decreases contractility via EP3. METHODS AND RESULTS: The effects of PGE2 and the EP1/EP3 agonist sulprostone on contractility were examined in the mouse Langendorff preparation and in adult mouse cardiomyocytes...
August 2016: Circulation. Heart Failure
Bridget Shoulders, Jillian Mauriello, Tamika Shellman, Corrinne Follett
The field of electrophysiology (EP) has rapidly evolved from a focus on diagnostic procedures to an emphasis on interventions. Many cardiac arrhythmias traditionally treated with antiarrhythmic agents, cardioversion, or cardiac surgery are now routinely cured with cardiac ablation. To optimally manage the care of cardiac ablation patients, it is essential that nurses have an understanding of the EP procedures and related nursing implications. There are extensive evidence-based resources available in the medical literature; however, there are limited publications geared toward nurses caring for cardiac ablation patients...
September 2016: Dimensions of Critical Care Nursing: DCCN
Parikshit S Sharma, Santosh K Padala, Sampath Gunda, Jayanthi N Koneru, Kenneth A Ellenbogen
INTRODUCTION: Vascular access related complications are the most common complications from catheter based EP procedures and have been reported to occur in 1-13% of cases. We prospectively assessed vascular complications in a large series of consecutive patients undergoing catheter based electrophysiologic (EP) procedures with ultrasound (US) guided vascular access versus conventional access. METHODS AND RESULTS: Consecutive patients undergoing catheter ablation procedures at VCU medical center were included...
October 2016: Journal of Cardiovascular Electrophysiology
Don Curtis Deno, Ram Balachandran, Dennis Morgan, Faiz Ahmad, Stephane Masse, Kumaraswarmy Nanthakumar
: Cardiac electrogram (EGM) signals and electrophysiologic (EP) characteristics derived from them such as amplitude and timing are central to the diagnosis and therapeutic management of arrhythmias. Bipolar EGMs are often used but possess polarity and shape dependence on catheter orientation contributing to uncertainty. OBJECTIVE: We describe a novel method to map cardiac activation that resolves signals into meaningful directions and is insensitive to electrode directional effects...
July 7, 2016: IEEE Transactions on Bio-medical Engineering
Mario Njeim, Benoit Desjardins, Frank Bogun
Recent advances in 3-dimensional electroanatomical mapping have been met by continuous improvements in the field of cardiac imaging and image integration during ablation procedures. Echocardiography, computed tomography, cardiac magnetic resonance, and nuclear imaging provide information about cardiac anatomy and ultrastructure of the heart that may be crucial for a successful ablation procedure. Techniques and value of pre-procedural, intraprocedural, and post-procedural imaging and image integration are discussed in this review article...
July 2016: JACC. Cardiovascular Imaging
Mohamed Akhatim Alsammani, Neimat Abdalhadi Moona
BACKGROUND: Ectopic pregnancy (EP) is the commonest cause of maternal mortality-related death in the first trimester. Methotrexate (MTX) remains the first-line treatment in optimally selected patients. OBJECTIVE: To evaluate the success rate and predictors of success of a single-dose MTX treatment in EP. SUBJECTS AND METHOD: We studied retrospectively 109 patients with unruptured EP who were treated with Intramuscular MTX administered in a dose of 50 mg/m(2) on days 0 and in additional doses on day 7 if β-hCG levels did not decrease by 15 % during the follow-up period...
August 2016: Journal of Obstetrics and Gynaecology of India
Gaston A Rodriguez-Granillo, Alejandro Deviggiano, Carlos Capunay, Macarena C De Zan, Patricia Carrascosa
BACKGROUND: Reproducibility data of the extent and patterns of late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) is limited. OBJECTIVE: To explore the reproducibility of regional wall thickness (WT), LGE extent, and LGE patterns in patients with HCM assessed with cardiac magnetic resonance (CMR). METHODS: The extent of LGE was assessed by the number of segments with LGE, and by the total LV mass with LGE (% LGE); and the pattern of LGE-CMR was defined for each segment...
July 2016: Arquivos Brasileiros de Cardiologia
Roland Tilz, Serge Boveda, Jean-Claude Deharo, Dan Dobreanu, Kristina H Haugaa, Nikolaos Dagres
The aim of this EP Wire was to assess the management, indications, and techniques for implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) device replacement in Europe. A total of 24 centres in 14 European countries completed the questionnaire. All centres were members of the European Heart Rhythm Association Electrophysiology Research Network. Replacement procedures were performed by electrophysiologists in 52% of the centres, by cardiologists in 33%, and both in the remaining centres...
June 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Maria Sobolev, Ariel L Shiloh, Luigi Di Biase, David P Slovut
AIMS: In an effort to minimize periprocedural stroke risk, increasingly, electrophysiological (EP) procedures are being performed on anticoagulation. The decrease in stroke has been accompanied by an increase in potentially devastating vascular access complications. Ultrasound guidance for femoral vein cannulation reduces complications in other applications. The aim of this study is to determine the utility of real-time two-dimensional (2D) ultrasound guidance for femoral vein cannulation in EP...
May 20, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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