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https://www.readbyqxmd.com/read/27909513/assessment-of-sinoatrial-node-function-in-patients-with-persistent-and-long-standing-persistent-forms-of-atrial-fibrillation-after-maze-iii-procedure-combined-with-mitral-valve-operation
#1
Kulikov Aleksei A, Bokeria Leo A
RESEARCH OBJECTIVE: Assessment of sinoatrial node function after Maze III procedure combined with a mitral valve operation. METHODS: 100 patients were included in the research with persistent and long-standing persistent forms of atrial fibrillation (AF) and need of operative treatment concerning valve disease. The following preoperative preparation methods were executed to all patients: Electrocardiogram in 12 standard assignments;Two-dimensional echocardiographic with assessment of systolic and diastolic functions of the left ventricle, size of the left atrium and grade of valve disease;Transesophageal echocardiography for exclusion of blood clots in the left atrium and left atrial appendage;Coronary angiography for exclusion of coronary heart disease;Computer tomography for examination of cardiac chambers and anatomic characteristics of pulmonary veins...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27905927/characteristics-and-outcomes-of-diabetic-patients-with-an-implantable-cardioverter-defibrillator-in-a-real-world-setting-results-from-the-israeli-icd-registry
#2
Hillel Steiner, Michael Geist, Ilan Goldenberg, Mahmoud Suleiman, Michael Glikson, Alexander Tenenbaum, Moshe Swissa, Enrique Z Fisman, Gregory Golovchiner, Boris Strasberg, Alon Barsheshet
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry...
December 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27882138/impact-of-ethyl-pyruvate-on-adriamycin-induced-cardiomyopathy-in-rats
#3
Menglin Liu, Menglong Wang, Jianfang Liu, Zhen Luo, Lei Shi, Ying Feng, Li Li, Lin Xu, Jun Wan
Ethyl pyruvate (EP), a derivative of pyruvic acid, is known to have protective effects against ischemic cardiomyopathy and other disorders. However, little is known about its role in Adriamycin (ADR)-induced cardiomyopathy. The present study was designed to investigate the impact of EP on ADR-induced cardiomyopathy in an animal model. Sixty male Sprague-Dawley (SD) rats were divided into four groups: Normal control, EP, ADR and ADR + EP groups (n=15/group). Rats in the ADR and ADR + EP groups were treated with ADR (2...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27875131/non-invasive-personalisation-of-a-cardiac-electrophysiology-model-from-body-surface-potential-mapping
#4
Sophie Giffard-Roisin, Thomas Jackson, Lauren Fovargue, Jack Lee, Herve Delingette, Reza Razavi, Nicholas Ayache, Maxime Sermesant
Modelling cardiac electrophysiology (EP) can help understand pathologies and predict the response to therapies. Moreover, estimating patient-specific parameters of the EP model is crucial to obtain personalised information. The novelty of this paper is to use non-invasive data (body surface potential mapping, BSPM) in order to personalise the main parameters of a cardiac EP model for predicting different pacing conditions. First, an efficient forward model is proposed, coupling the Mitchell- Schaeffer transmembrane potential model with a current dipole formulation...
November 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27861115/leadless-cardiac-pacing-what-primary-care-providers-and-non-ep-cardiologists-should-know
#5
REVIEW
Erich L Kiehl, Daniel J Cantillon
Over the last 50 years, the use of transvenous pacemakers has been constrained by long-term complications that affect more than 1 in 10 patients, largely attributable to the endovascular leads and surgical pocket. Leadless cardiac pacing involves a self-contained pacemaker deployed directly into the heart without a lead or incisional access. The procedure has shown promise, eliminating pocket-related complications. Other advantages include postprocedural shoulder mobility and the ability to drive, shower, and bathe...
November 2016: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/27859254/influence-of-experimental-periodontitis-on-cardiac-oxidative-stress-in-rats-a-biochemical-and-histomorphometric-study
#6
O Köse, T Arabacı, H Yemenoglu, S Ozkanlar, N Kurt, I Gumussoy, S Gedikli, A Kara
BACKGROUND AND OBJECTIVE: The role of oxidative stress in the process of cardiac remodeling, hypertrophy and heart failure is a current topic. The purpose of this experimental study was to investigate the influences of periodontitis on levels of cardiac oxidative stress. MATERIAL AND METHODS: Twenty rats were separated into two groups: control and experimental periodontitis (EP). Periodontitis was induced by placing a 3.0 silk suture in the cervix of the left and right mandibular first molar teeth for 5 wk...
November 17, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27832737/oral-mucosa-harbors-a-high-frequency-of-endothelial-cells-a-novel-postnatal-cell-source-for-angiogenic-regeneration
#7
Jian Zhou, Jason Rogers, Scott Lee, DongMing Sun, Hai Yao, Jeremy J Mao, Kimi Y Kong
Endothelial progenitor cells/endothelial cells (EPCs/ECs) have great potential to treat pathological conditions such as cardiac infarction, muscle ischemia and bone fractures but isolation of EPC/ECs from existing cell sources is challenging due to their low endothelial cell frequency. We have isolated EP-like cells from rat oral mucosa and characterized their yield, immunophenotype, growth and in vivo angiogenic potential. The frequency of EP-like cells derived from oral mucosa is thousands of folds higher than EPCs derived from donor-match bone marrow samples...
November 10, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27815478/new-validated-signal-averaging-based-electrocardiography-method-to-determine-his-ventricle-interval
#8
Balázs Németh, Lóránd Kellényi, István Péterfi, Tamás Simor, Diána Ruzsa, Holczer Lőrinc, István Kiss, Iván Péter, Zénó Ajtay
BACKGROUND/AIM: The signal-averaging (SA) technique is used to record high-resolution electrocardiograms (HRECGs) showing cardiac micropotentials. We aimed to develop a non-invasive signal-averaging-based portable bedside device to determine His-ventricle interval. PATIENTS AND METHODS: After amplifying the HRECG recordings, signal duration and voltage can be measured up to four decimal precision. To validate our system, comparison of the invasively and non-invasively determined HV intervals has been performed in 20 patients...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27796075/an-atlas-and-data-driven-approach-to-initializing-reaction-diffusion-systems-in-computer-cardiac-electrophysiology
#9
Corné Hoogendoorn, Rafael Sebastian, José Félix Rodriguez, Karim Lekadir, Alejandro F Frangi
The cardiac electrophysiology (EP) problem is governed by a nonlinear anisotropic reaction-diffusion system with a very rapidly varying reaction term associated with the transmembrane cell current. The nonlinearity associated with the cell models requires a stabilization process before any simulation is carried out. More importantly, when used in a three-dimensional (3D) anatomy, it is not sufficient to perform this stabilization on the basis of isolated cells only, since the coupling of the different cells through the tissue greatly modulates the dynamics of the system...
October 30, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27742774/cardiac-arrhythmias-in-patients-with-danon-disease
#10
Torsten Konrad, Sebastian Sonnenschein, Frank Patrick Schmidt, Hanke Mollnau, Karsten Bock, Blanca Quesada Ocete, Thomas Münzel, Cathrin Theis, Thomas Rostock
AIMS: Different cardiac arrhythmias have been suggested to be associated with Danon disease, e.g. Wolff-Parkinson-White syndrome. However, a systematic electrophysiological investigation of patients with Danon disease is lacking thus far. METHODS AND RESULTS: Seven patients with Danon disease (4 males, 35.8 ± 10.8 years; 3 females, 51.3 ± 19.9 years) from 3 different families were studied. In all patients, the presence of Danon disease was confirmed by western blot of biopsy material or genetic testing...
October 14, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27740477/4-d-ice-a-2-d-array-transducer-with-integrated-asic-in-a-10-fr-catheter-for-real-time-3-d-intracardiac-echocardiography
#11
Douglas Wildes, Warren Lee, Bruno Haider, Scott Cogan, Krishnakumar Sundaresan, David M Mills, Christopher Yetter, Patrick H Hart, Christopher R Haun, Mikael Concepcion, Johan Kirkhorn, Marc Bitoun
We developed a 2.5 ×6.6 mm (2) 2 -D array transducer with integrated transmit/receive application-specific integrated circuit (ASIC) for real-time 3-D intracardiac echocardiography (4-D ICE) applications. The ASIC and transducer design were optimized so that the high-voltage transmit, low-voltage time-gain control and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019-mm (2) area of the element. The transducer assembly was deployed in a 10-Fr (3...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27669728/epicardial-potentials-computed-from-the-body-surface-potential-map-using-inverse-electrocardiography-and-an-individualised-torso-model-improve-sensitivity-for-acute-myocardial-infarction-diagnosis
#12
Michael J Daly, Dewar D Finlay, Daniel Guldenring, Raymond R Bond, Aaron J McCann, Peter J Scott, Jennifer A Adgey, Mark T Harbinson
INTRODUCTION: Epicardial potentials (EPs) derived from the body surface potential map (BSPM) improve acute myocardial infarction (AMI) diagnosis. In this study, we compared EPs derived from the 80-lead BSPM using a standard thoracic volume conductor model (TVCM) with those derived using a patient-specific torso model (PSTM) based on body mass index (BMI). METHODS: Consecutive patients presenting to both the emergency department and pre-hospital coronary care unit between August 2009 and August 2011 with acute ischaemic-type chest pain at rest were enrolled...
September 26, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27614966/effects-of-shenfu-injection-on-cerebral-metabolism-in-a-porcine-model-of-cardiac-arrest
#13
Qin Yin, Cai-Jun Wu, Jun Yang, Chen-Chen Hang, Chun-Sheng Li
OBJECTIVE: To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). METHODS: Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC)...
September 10, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27614451/effects-of-shen-fu-injection-on-apoptosis-of-regulatory-t-lymphocytes-in-spleen-during-post-resuscitation-immune-dysfunction-in-a-porcine-model-of-cardiac-arrest
#14
Wei Gu, Qian Zhang, Chun-Sheng Li
OBJECTIVE: To investigate whether Shen-Fu Injection (, SFI) reduces post-resuscitation immune dysfunction in a porcine model of cardiac arrest by modulating apoptosis of regulatory T lymphocytes (Treg) in the spleen. METHODS: After 8-min untreated ventricular fibrillation and 2-min basic life support, 24 pigs were divided into 3 groups with a random number table, i.e. SFI group, epinephrine (EP) group, and saline (SA) group (8 in each group), which received central venous injection of SFI (1...
September 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27594972/an-update-of-microsomal-prostaglandin-e-synthase-1-and-pge2-receptors-in-cardiovascular-health-and-diseases
#15
REVIEW
Guangrui Yang, Lihong Chen
Nonsteroidal anti-inflammatory drugs (NSAIDs), especially cyclooxygenase-2 (COX-2) selective inhibitors, are among the most widely used drugs to treat pain and inflammation. However, clinical trials have revealed that these inhibitors predisposed patients to a significantly increased cardiovascular risk, consisting of thrombosis, hypertension, myocardial infarction, heart failure, and sudden cardiac death. Thus, microsomal prostaglandin E (PGE) synthase-1 (mPGES-1), the key terminal enzyme involved in the synthesis of inflammatory prostaglandin E2 (PGE2), and the four PGE2 receptors (EP1-4) have gained much attention as alternative targets for the development of novel analgesics...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27557795/elevated-c-type-natriuretic-peptide-elicits-exercise-preconditioning-induced-cardioprotection-against-myocardial-injury-probably-via-the-up-regulation-of-npr-b
#16
Jiao Lu, Shan-Shan Pan
To evaluate exercise preconditioning (EP)-induced cardioprotective effects against exercise-induced acute myocardial injury and investigate the alterations of C-type natriuretic peptide (CNP) and its specific receptor, natriuretic peptide receptor B (NPR-B), during EP-induced cardioprotection. Rats were subjected to treadmill exercise as an EP model (4 periods of 10 min each at 30 m/min with intervening periods of rest lasting 10 min). High-intensity exercise was performed 0.5 and 24 h after the EP. EP attenuated high-intensity exercise-induced myocardial injury in both the early and late phases...
August 24, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27553931/magnetic-resonance-imaging-guided-transatrial-electrophysiological-studies-in-swine-using-active-catheter-tracking-experience-with-14-cases
#17
Matthias Grothoff, Matthias Gutberlet, Gerhard Hindricks, Christian Fleiter, Bernhard Schnackenburg, Steffen Weiss, Sascha Krueger, Christopher Piorkowski, Thomas Gaspar, Steve Wedan, Thomas Lloyd, Philipp Sommer, Sebastian Hilbert
OBJECTIVES: To evaluate the feasibility of performing comprehensive Cardiac Magnetic resonance (CMR) guided electrophysiological (EP) interventions in a porcine model encompassing left atrial access. METHODS: After introduction of two femoral sheaths 14 swine (41 ± 3.6 kg) were transferred to a 1.5 T MR scanner. A three-dimensional whole-heart sequence was acquired followed by segmentation and the visualization of all heart chambers using an image-guidance platform...
August 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27547041/implementation-of-a-screening-program-for-patients-at-risk-for-posttraumatic-stress-disorder
#18
Carmen R Roberts, Joanie E Wofford, Haley M Hoy, Mitchell N Faddis
INTRODUCTION: Implantable cardioverter defibrillator (ICD) recipients who suffer from posttraumatic stress disorder (PTSD) are known to be associated with significant cardiac-specific mortality. Clinical observations suggest that PTSD is frequently undetected in ICD recipients followed up at electrophysiology (EP) outpatient clinics. Early recognition of PTSD is important to reduce the risk of serious manifestations on patient outcomes. METHODS: All ICD recipients aged 19 years or older at the Washington University School of Medicine (WASHU) EP clinic, a large urban EP clinic, were invited to participate in the project...
2016: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/27517167/hemodynamic-performance-of-endovascular-valves-as-valve-in-valve-in-small-stented-bioprosthesis
#19
Ralf-Uwe Kuehnel, Martin Hartrumpf, Michael Erb, Johannes M Albes
Objective Endovascular valve in stented biological valve implantation (valve-in-valve transcatheter aortic valve implantation [TAVI ViV]) is increasingly becoming a valid option for bioprosthesis degeneration. TAVI implantation in small stented biological valves below 23 mm is controversially discussed. Reduced opening area and high gradients are typical objections against this procedure in cases of small bioprosthesis. Systematic studies about the hemodynamic performance of endovascular valves in small stented bioprosthesis, however, do not exist...
August 12, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27508803/-op-1c-02-spectral-estimation-of-peterson-s-modulus-variability-from-arterial-blood-pressure-and-wavelet-analysis
#20
A J Ramirez, F Pessana, P Zenone, N Linale, R Sanchez
OBJECTIVE: Arterial stiffness is mainly characterized by its Peterson's Modulus (EP). Increased values of EP are associated with a reduced heart function and an increased arterial blood pressure. Assessment of EP requires simultaneous measurements of arterial diameter and pressure signals. However, instantaneous determination of arterial diameter signals implies optical and ultrasonic techniques and neither of them are portables. AIMS: To evaluate a novel method for estimating the Ep spectral variability of arterial stiffness, without arterial diameter signals...
September 2016: Journal of Hypertension
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