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https://www.readbyqxmd.com/read/29237514/the-effects-of-intraoperative-sedation-on-surgical-outcomes-of-deep-brain-stimulation-surgery
#1
Jason Chui, Rizq Alimiri, Andrew Parrent, Rosemary Ann Craen
BACKGROUND: Intraoperative sedation is often used to facilitate deep brain stimulation (DBS) surgery; however, these sedative agents also suppress microelectrode recordings (MER). To date, there have been no studies that have examined the effects of differing sedatives on surgical outcomes and the success of DBS surgery. METHODS: We performed a retrospective study to evaluate the effect of differing sedative agents on postoperative surgical outcomes at 6 months in parkinsonian adult patients who underwent DBS surgery, from January 2004 through December 2014, at one academic center...
December 14, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29236528/role-of-clinical-neuropsychology-in-deep-brain-stimulation-review-of-the-literature-and-considerations-for-clinicians
#2
Joseph A Mole, Simon J Prangnell
Deep Brain Stimulation (DBS) is an effective surgical therapy for several neurological movement disorders. The clinical neuropsychologist has a well-established role in the neuropsychological evaluation and selection of surgical candidates. In this article, we argue that the clinical neuropsychologist's role is much broader, when considered in relation to applied psychologists' core competencies. We consider the role of the clinical neuropsychologist in DBS in relation to: assessment, formulation, evaluation and research, intervention or implementation, and communication...
December 13, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29235446/optimized-programming-algorithm-for-cylindrical-and-directional-deep-brain-stimulation-electrodes
#3
Daria Nesterovich Anderson, Braxton Osting, Johannes Vorwerk, Alan Chuck Dorval, Christopher R Butson
 Deep brain stimulation (DBS) is a growing treatment option for movement and psychiatric disorders. As DBS technology moves toward directional leads with increased numbers of smaller electrode contacts, trial-and-error methods of manual DBS programming are becoming too time-consuming for clinical feasibility. We propose an algorithm to automate DBS programming in near real-time for a wide range of DBS lead designs. Approach: Magnetic resonance imaging and diffusion tensor imaging are used to build finite element models that include anisotropic conductivity...
December 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29233537/life-threatening-parkinsonism-hyperpyrexia-syndrome-following-bilateral-deep-brain-stimulation-of-the-subthalamic-nucleus
#4
Mehmet Osman Akçakaya, Nihan Hande Akçakaya, Mustafa Ömür Kasımcan, Talat Kırış
Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times...
December 6, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29232685/surgical-management-of-deep-brain-stimulator-scalp-erosion-without-hardware-removal
#5
Michael D Staudt, Navid Pourtaheri, Gregory E Lakin, Hooman T Soltanian, Jonathan P Miller
BACKGROUND: Scalp erosion in patients with deep brain stimulation (DBS) hardware is an uncommon complication that lacks a clearly defined management strategy. Previous studies have described various therapies including conservative treatment with antibiotics and surgical debridement with or without hardware removal. OBJECTIVES: The aim of this study was to review the efficacy of a hardware-sparing management strategy for the treatment of scalp erosion. METHODS: Five patients with previous DBS implantation presented with scalp erosion and visible hardware exposure at the calvarial burr hole site, and underwent tension-free, vascularized, rotational scalp flap, with preservation of the leads under the pericranium...
December 13, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29232019/thalamic-deep-brain-stimulation-for-essential-tremor-also-reduces-voice-tremor
#6
Bornali Kundu, Lauren Schrock, Tyler Davis, Paul A House
OBJECTIVE: Voice tremor is a common feature of essential tremor (ET) that is difficult to treat medically and significantly affects quality of life. Deep brain stimulation (DBS) of the ventral intermediate nucleus (Vim) of the thalamus is effective in improving contralateral distal limb tremor and has been shown in limited studies to affect voice tremor. Our objective was to retrospectively evaluate whether Vim-DBS used to treat patients with essential motor tremor also effectively treated underlying concurrent voice tremor and assess whether particular lead locations were favorable for treating vocal tremor...
December 12, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29228144/randomized-controlled-trial-of-daily-text-messages-to-support-adherence-to-prep-in-at-risk-for-hiv-individuals-the-tapir-study
#7
David J Moore, Sonia Jain, Michael P Dubé, Eric S Daar, Xiaoying Sun, Jason Young, Katya Corado, Eric Ellorin, Joel Milam, Deborah Collins, Jill Blumenthal, Brookie M Best, Peter Anderson, Richard Haubrich, Sheldon R Morris
Background: Adherence is critical for efficacy of tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis (PrEP). Methods: Between 02/2013 and 02/2016, 398 men who have sex with men and transgender women were randomized 1:1 to receive individualized Texting for Adherence Building (iTAB) or standard care (SoC) for 48 weeks. The primary endpoint was dried blood spot (DBS) tenofovir (TFV-DP) concentrations at both week 12 and week 48 (or the last on-drug visit) of >719 fmol/punch consistent with ≥4 doses per week (i...
November 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29225467/altered-emotional-recognition-and-expression-in-patients-with-parkinson-s-disease
#8
Yazhou Jin, Zhiqi Mao, Zhipei Ling, Xin Xu, Zhiyuan Zhang, Xinguang Yu
Background: Parkinson's disease (PD) patients exhibit deficits in emotional recognition and expression abilities, including emotional faces and voices. The aim of this study was to explore emotional processing in pre-deep brain stimulation (pre-DBS) PD patients using two sensory modalities (visual and auditory). Methods: Fifteen PD patients who needed DBS surgery and 15 healthy, age- and gender-matched controls were recruited as participants. All participants were assessed by the Karolinska Directed Emotional Faces database 50 Faces Recognition test...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29224166/dna-methylation-analysis-from-blood-spots-increasing-yield-and-quality-for-genome-wide-and-locus-specific-methylation-analysis
#9
Akram Ghantous, Hector Hernandez-Vargas, Zdenko Herceg
Blood represents an easily accessible human tissue for numerous research and clinical applications, including surrogate roles for biomarkers of other tissues. Dried blood spots (DBS) are space- and cost-efficient storage forms of blood while stably retaining many of its chemical constituents. Consequently, neonatal DBS are routinely collected in many countries, and their biobanks represent gold mines for research. However, the utility of DBS is restricted by the limited amount and quality of extractable biomolecules (including DNA), especially for genome-wide profiling...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29223050/a-simple-rapid-and-stability-indicating-validated-method-for-quantification-of-lamotrigine-in-human-plasma-and-dry-plasma-spot-using-lc-esi-ms-ms-application-in-clinical-study
#10
Kuldeep Kumar Namdev, Jaya Dwivedi, Deepak Chandra Chilkoti, Swapnil Sharma
Lamotrigine (LTZ) is a phenyltriazine derivative which belongs to anti-epileptic drugs (AEDs) class and prescribed as mono- or adjunctive-therapy in treatment of epilepsy. Therapeutic drug monitoring (TDM) of AEDs provides a valid clinical tool in optimization of overall therapy. However, TDM is challenging due to the high biological samples (plasma/blood) storage/shipment costs and the limited availability of laboratories providing TDM services. Sampling in the form of dry plasma spot (DPS) or dry blood spot (DBS) are suitable alternative to overcome these issues...
December 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#11
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
December 8, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29222715/clinical-validation-study-of-dried-blood-spot-for-determining-everolimus-concentration-in-patients-with-cancer
#12
A E C A B Willemsen, L M Knapen, Y M de Beer, R J M Brüggemann, S Croes, C M L van Herpen, N P van Erp
PURPOSE: Everolimus treatment is seriously hampered by its toxicity profile. As a relationship between everolimus exposure and effectiveness and toxicity has been established, early and ongoing concentration measurement can be key to individualize the dose and optimize treatment outcomes. Dried blood spot (DBS) facilitates sampling at a patients' home and thereby eases dose individualization. The aim of this study is to determine the agreement and predictive performance of DBS compared to whole blood (WB) to measure everolimus concentrations in cancer patients...
December 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29219219/ultrahigh-magnitude-brain-magnetic-resonance-imaging-scan-on-rhesus-monkeys-with-implanted-deep-brain-stimulation-hardware
#13
Jun-Ju Li, Lin Shi, Ying-Chuan Chen, Guan-Yu Zhu, Jian-Guo Zhang
BACKGROUND: Patients with implanted deep brain stimulation (DBS) hardware are prohibited from undergoing magnetic resonance imaging (MRI) scans at magnitudes greater than 1.5 T to avoid potential MRI-related heating injury. Whether DBS devices are compatible with higher field MRI scanning is unknown. This study aimed to investigate whether 7.0 T and 3.0 T MRI scans can be safely performed on rhesus monkeys with implanted DBS devices. METHODS: Eight male rhesus monkeys were included in this study and stereotactically implanted with DBS devices in the left anterior thalamus...
December 8, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29218702/deep-brain-stimulation-for-drug-resistant-epilepsy
#14
REVIEW
Michael C H Li, Mark J Cook
OBJECTIVES: To review clinical evidence on the antiepileptic effects of deep brain stimulation (DBS) for drug-resistant epilepsy, its safety, and the factors influencing individual outcomes. METHODS: A comprehensive search of the medical literature (PubMed, Medline) was conducted to identify relevant articles investigating DBS therapy for drug-resistant epilepsy. Reference lists of these articles were used to source further articles. RESULTS: Stimulation of the anterior nucleus of the thalamus (ANT) and hippocampus (HC) has been shown to decrease the frequency of refractory seizures...
December 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/29217994/local-fields-in-human-subthalamic-nucleus-track-the-lead-up-to-impulsive-choices
#15
John M Pearson, Patrick T Hickey, Shivanand P Lad, Michael L Platt, Dennis A Turner
The ability to adaptively minimize not only motor but cognitive symptoms of neurological diseases, such as Parkinson's Disease (PD) and obsessive-compulsive disorder (OCD), is a primary goal of next-generation deep brain stimulation (DBS) devices. On the basis of studies demonstrating a link between beta-band synchronization and severity of motor symptoms in PD, the minimization of beta band activity has been proposed as a potential training target for closed-loop DBS. At present, no comparable signal is known for the impulsive side effects of PD, though multiple studies have implicated theta band activity within the subthalamic nucleus (STN), the site of DBS treatment, in processes of conflict monitoring and countermanding...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29216585/determination-of-irinotecan-and-its-metabolite-sn-38-in-dried-blood-spots-using-high-performance-liquid-chromatography-with-fluorescence-detection
#16
Roberta Z Hahn, Priscila C Arnhold, Natália B Andriguetti, Anelise Schneider, Helena M Klück, Simone L Dos Reis, Marcos Frank Bastiani, Igor Kael, Anne Caroline Cezimbra da Silva, Gilberto Schwartsmann, Marina V Antunes, Rafael Linden
Irinotecan (IRI) is an antineoplastic drug widely used for the treatment of colorectal and advanced pancreatic cancer. Despite its clinical utility, the clinical use of IRI is associated with potentially severe hematopoietic and gastrointestinal toxicities. The quantification of IRI and its active metabolite SN-38 in dried blood spots (DBS) may be an alternative to individualize the drug dose through a minimally invasive and easy collection method. The aim of this study was to develop and validate a simple and fast HPLC-FL assay for simultaneous IRI and SN-38 measurement in DBS, with adequate analytical performance for clinical use...
December 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29215735/vacuolated-pas-positive-lymphocytes-as-an-hallmark-of-pompe-disease-and-other-myopathies-related-to-impaired-autophagy
#17
Angelo Pascarella, Chiara Terracciano, Olimpia Farina, Luca Lombardi, Teresa Esposito, Filomena Napolitano, Giuseppina Franzese, Giovanni Panella, Francesco Tuccillo, Giancarlo la Marca, Sergio Bernardini, Silvia Boffo, Antonio Giordano, Mariarosa Anna Beatrice Melone, Giuseppe Di Iorio, Simone Sampaolo
Autosomal recessive Pompe disease is a lysosomal disorder caused by mutations of the acid-α-glucosidase (GAA) gene. Deficiency of GAA enzyme leads to glycogen accumulation and autophagy impairment in cardiac and skeletal muscles, but also in lymphocytes. Since an effective therapy is available, a rapid, sensitive and specific test is crucial to early identify affected subjects. Number of lymphocytes containing PAS-positive vacuoles was evaluated on blood films from 72 consecutive adult patients with hyperckemia and/or muscle weakness, 13 genetically confirmed late-onset-Pompe-disease (LOPD) and 13 of their offspring...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29211858/iohexol-plasma-clearance-simplified-by-dried-blood-spot-testing
#18
Sergio Luis-Lima, Flavio Gaspari, Natalia Negrín-Mena, Fabiola Carrara, Laura Díaz-Martín, Alejandro Jiménez-Sosa, Federico González-Rinne, Armando Torres, Esteban Porrini
Background: Renal function can be estimated with formulas, which are inaccurate, or measured with gold standard methods, which are reliable but unpractical. We propose to simplify the plasma clearance of iohexol, a gold standard method to measure renal function, by dried blood spot (DBS) testing. Methods: We compared glomerular filtration rate (GFR) values assessed by DBS and the reference plasma analysis technique. We tested in vitro the agreement between non-volumetric and volumetric DBS with the reference technique...
December 4, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29211599/quantitation-of-salbutamol-using-micro-volume-blood-sampling-applications-to-exacerbations-of-pediatric-asthma
#19
Rebecca L Cordell, Thalassa S E Valkenburg, Hitesh C Pandya, Daniel B Hawcutt, Malcolm G Semple, Paul S Monks
OBJECTIVES: A novel gas chromatography-mass spectrometry (GC-MS) method has been developed to quantify salbutamol in micro-volumes (10 µL) of blood. A potential application is paediatric therapeutic dose monitoring (TDM) in acute severe asthma. METHODS: At presentation, the children receive multiple doses of salbutamol (inhaled, nebulised and occasionally intravenous) but it is difficult to distinguish children who do not respond to treatment because of inadequate concentrations from those with toxicity, as symptoms are similar...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29201549/l-dopa-carbidopa-intestinal-gel-and-subthalamic-nucleus-stimulation-effects-on-cognition-and-behavior
#20
Francesc Valldeoriola, Pilar Santacruz, José Ríos, Yaroslau Compta, Jordi Rumià, José Esteban Muñoz, María José Martí, Eduardo Tolosa
Objective: In Parkinson's disease (PD), effects on behavior and cognition of levodopa/carbidopa intestinal gel (LCIG) and subthalamic stimulation (STN-DBS) and their practical consequences remain controversial. This study was designed to analyze the possible effects of these therapies on cognition and behavior after 1 year follow-up. Methods: This was an open-label, nonrandomized prospective study for pre- and postintervention analyses. Twenty-four patients were considered eligible to be candidates for complex therapies such as STN-DBS or LCIG; 23 patients treated with standard medication were included as controls...
November 2017: Brain and Behavior
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