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https://www.readbyqxmd.com/read/29912203/an-invasive-method-for-the-activation-of-the-mouse-dentate-gyrus-by-high-frequency-stimulation
#1
Zhe Zhao, Haitao Wu
Electrical high-frequency stimulation (HFS), using implanted electrodes targeting various brain regions, has been proven as an effective treatment for various neurological and psychiatric disorders. HFS in the deep region of the brain, also named deep-brain stimulation (DBS), is becoming increasingly important in clinical trials. Recent progress in the field of high-frequency DBS (HF-DBS) surgery has begun to spread the possibility of utilizing this invasive technique to other situations, such as treatment for major depression disorder (MDD), obsessive-compulsive disorder (OCD), and so on...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911146/evaluation-of-dried-blood-spot-as-an-alternative-sample-collection-method-for-hepatitis-c-virus-rna-quantitation-and-genotyping-using-a-commercial-system
#2
Supriya Mahajan, Manish Chandra Choudhary, Guresh Kumar, Ekta Gupta
Dried blood spot (DBS) is a minimally invasive sampling method suitable for sample collection, storage and transportation in resource limited areas. Aim of this study was to compare the diagnostic utility of DBS with plasma sample for HCV RNA quantitation and genotyping using commercial systems. Plasma and DBS card spotted samples were collected from 95 HCV seropositive patients. Both types of samples were subjected to HCV RNA by real-time PCR (Abbott m2000rt, USA). Genotyping was performed using Abbott HCV genotype II kit (Abbott diagnostics, USA) in samples with viral load > 3 log10  IU/ml...
June 2018: Virusdisease
https://www.readbyqxmd.com/read/29910746/brain-stimulation-in-alzheimer-s-disease
#3
REVIEW
Chun-Hung Chang, Hsien-Yuan Lane, Chieh-Hsin Lin
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stimulation (IBS). IBS includes deep brain stimulation (DBS), and invasive vagus nerve stimulation (VNS), whereas NIBS includes transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), electroconvulsive treatment (ECT), magnetic seizure therapy (MST), cranial electrostimulation (CES), and non-invasive VNS...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29909467/subthalamic-deep-brain-stimulation-and-levodopa-in-parkinson-s-disease-a-meta-analysis-of-combined-effects
#4
REVIEW
Joaquin A Vizcarra, Miguel Situ-Kcomt, Carlo Alberto Artusi, Andrew P Duker, Leonardo Lopiano, Michael S Okun, Alberto J Espay, Aristide Merola
INTRODUCTION: While subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa improve motor symptoms in Parkinson disease (PD) to a similar magnitude, their combined effect remains unclear. We sought to evaluate whether STN-DBS and levodopa yield differential effects on motor outcomes, dyskinesia, and activities of daily living (ADL) when combined compared to when administered alone. METHODS: We conducted a meta-analysis of all studies reporting motor, dyskinesia, and ADL outcomes after bilateral STN-DBS in PD with presurgical Unified Parkinson's Disease Rating Scale (UPDRS-III) in Medication-OFF and Medication-ON states and postsurgical assessments in four conditions: Stimulation-ON/Medication-ON, Stimulation-ON/Medication-OFF, Stimulation-OFF/Medication-ON, and Stimulation-OFF/Medication-OFF...
June 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29909184/rates-causes-risk-factors-and-outcomes-of-readmission-following-deep-brain-stimulation-for-movement-disorders-analysis-of-the-u-s-nationwide-readmissions-database
#5
Kavelin Rumalla, Kyle A Smith, Kenneth A Follett, Jules M Nazzaro, Paul M Arnold
OBJECTIVE: Deep brain stimulation (DBS) surgery has proven benefit for several movement disorders and medically-refractory psychiatric conditions and is considered a fairly safe procedure. We sought to determine the national rates, causes, predictors, and outcomes associated with 30-day and 90-day readmission. PATIENTS AND METHODS: The Nationwide Readmissions Database was queried (January-September 2013) using ICD-9-CM codes, identifying patients who underwent DBS for movement disorder (Parkinson's disease [PD], essential tremor [ET], or dystonia)...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29908405/objective-predictors-of-early-tolerance-to-ventral-intermediate-nucleus-of-thalamus-deep-brain-stimulation-in-essential-tremor-patients
#6
Shabbir Hussain Merchant, Sheng-Han Kuo, Yu Qiping, Linda Winfield, Guy McKhann, Sameer Sheth, Seth L Pullman, Blair Ford
OBJECTIVE: To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit 'early tolerance' to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS). METHODS: Identification of comparative characteristics of defined cases of 'early tolerance' versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis...
June 5, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29906569/salival-%C3%AE-iduronidase-activity-as-a-potential-new-biomarker-for-the-diagnosis-and-monitoring-the-effect-of-therapy-in-mucopolysaccharidosis-i
#7
Jaap van Doorn, Brigitte T A van den Broek, Ans J Geboers, Gé-Ann Kuiper, J J Boelens, Peter M van Hasselt
Although disease progression in Mucopolysaccharidosis I (MPS-1) can be attenuated by hematopoietic cell transplantation (HCT), it is increasingly recognized that residual disease is substantial. Biomarkers that would allow us to evaluate the efficacy of HCT (and upcoming new therapies) in non-hematological tissues are needed. Current biomarkers, including the iduronidase (IDUA) activity in leukocytes, are not suitable for this purpose as they are assessed in tissues of hematological origin and may not reflect enzyme availability in non-hematologic tissues...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29904635/successful-treatment-of-holmes-tremor-with-deep-brain-stimulation-of-the-prelemniscal-radiations
#8
Vicente Martinez, Shu-Ching Hu, Thomas J Foutz, Andew Ko
Holmes tremor (HT) is a rare movement disorder that is typically associated with cerebellar, thalamic or brainstem lesions following a delay. Treatment of HT with deep brain stimulation (DBS) has yielded positive results however; it is unclear which deep brain targets provide optimal therapeutic effects. Here we describe a case report in which a 34 year old man with HT treated successfully with DBS. The ventrointermediate nucleus (VIM) of the thalamus was considered as the initial target. Following electrode placement we determined that the ventral-most electrode contacts were located in the prelemniscal radiations (Raprl)...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29904585/recent-advances-in-deep-brain-stimulation-in-psychiatric-disorders
#9
REVIEW
Anne-Hélène Clair, William Haynes, Luc Mallet
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life...
2018: F1000Research
https://www.readbyqxmd.com/read/29904367/resting-state-pallidal-cortical-oscillatory-couplings-in-patients-with-predominant-phasic-and-tonic-dystonia
#10
Fusako Yokochi, Kenji Kato, Hirokazu Iwamuro, Tsutomu Kamiyama, Katsuo Kimura, Akihiro Yugeta, Ryoichi Okiyama, Makoto Taniguchi, Satoko Kumada, Junichi Ushiba
Pallidal deep brain stimulation (DBS) improves the symptoms of dystonia. The improvement processes of dystonic movements (phasic symptoms) and tonic symptoms differ. Phasic symptoms improve rapidly after starting DBS treatment, but tonic symptoms improve gradually. This difference implies distinct neuronal mechanisms for phasic and tonic symptoms in the underlying cortico-basal ganglia neuronal network. Phasic symptoms are related to the pallido-thalamo-cortical pathway. The pathway related to tonic symptoms has been assumed to be different from that for phasic symptoms...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29900088/improving-the-standard-for-deep-brain-stimulation-therapy-target-structures-and-feedback-signals-for-adaptive-stimulation-current-perspectives-and-future-directions
#11
REVIEW
Franz Hell, Thomas Köglsperger, Jan Mehrkens, Kai Boetzel
Deep brain stimulation (DBS) is an established therapeutic option for the treatment of various neurological disorders and has been used successfully in movement disorders for over 25 years. However, the standard stimulation schemes have not changed substantially. Two major points of interest for the further development of DBS are target-structures and novel adaptive stimulation techniques integrating feedback signals. We describe recent research results on target structures and on neural and behavioural feedback signals for adaptive deep brain stimulation (aDBS), as well as outline future directions...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29899725/long-term-effect-of-gpi-dbs-in-a-patient-with-generalized-dystonia-due-to-glut1-deficiency-syndrome
#12
Idil Hanci, Christoph Kamm, Marlieke Scholten, Lorenzo P Roncoroni, Yvonne Weber, Rejko Krüger, Christian Plewnia, Alireza Gharabaghi, Daniel Weiss
Treatment outcomes from pallidal deep brain stimulation are highly heterogeneous reflecting the phenotypic and etiologic spectrum of dystonia. Treatment stratification to neurostimulation therapy primarily relies on the phenotypic motor presentation; however, etiology including genetic factors are increasingly recognized as modifiers of treatment outcomes. Here, we describe a 53 year-old female patient with a progressive generalized dystonia since age 25. The patient underwent deep brain stimulation of the globus pallidus internus (GPi-DBS) at age 44...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29898975/critical-appraisal-of-the-recent-us-fda-approval-for-earlier-dbs-intervention
#13
REVIEW
Laura Y Cabrera, John Goudreau, Christos Sidiropoulos
In November 2015, Medtronic announced the US Food and Drug Administration (FDA) approval for the use of deep brain stimulation (DBS) therapy in people with Parkinson disease (PD) "of at least 4 years duration and with recent onset motor complications, or motor complications of longer-standing duration that are not adequately controlled with medication." The approval was based on data from the EARLYSTIM clinical trial, a randomized, prospective, multicenter, parallel-group clinical trial in Germany and France involving 251 patients with PD...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898460/development-of-a-standardized-cranial-phantom-for-training-and-optimization-of-functional-stereotactic-operations
#14
Marie T Krüger, Volker A Coenen, Karl Egger, Mukesch Shah, Peter C Reinacher
BACKGROUND: In recent years, simulations based on phantom models have become increasingly popular in the medical field. In the field of functional and stereotactic neurosurgery, a cranial phantom would be useful to train operative techniques, such as stereo-electroencephalography (SEEG), to establish new methods as well as to develop and modify radiological techniques. In this study, we describe the construction of a cranial phantom and show examples for it in stereotactic and functional neurosurgery and its applicability with different radiological modalities...
June 13, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29896085/deep-brain-stimulation-a-potential-treatment-for-dementia-in-alzheimer-s-disease-ad-and-parkinson-s-disease-dementia-pdd
#15
REVIEW
Qing Lv, Ailian Du, Wenshi Wei, Yuanyuan Li, Gailing Liu, Xiao Ping Wang
Damage to memory circuits may lead to dementia symptoms in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD). Recently, deep brain stimulation (DBS) has been shown to be a novel means of memory neuromodulation when critical nodes in the memory circuit are targeted, such as the nucleus basalis of Meynert (NBM) and fornix. Potential memory improvements have been observed after DBS in patients with AD and PDD. DBS for the treatment of AD and PDD may be feasible and safe, but it is still preliminary...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29895269/identity-challenges-and-burden-of-normality-after-dbs-for-severe-ocd-a-narrative-case-study
#16
Peter Bosanac, Bridget Elizabeth Hamilton, James Lucak, David Castle
BACKGROUND: Deep Brain Stimulation (DBS) is an emerging and potentially powerful biological treatment for severe Obsessive-Compulsive Disorder (OCD), but the wider impact of the intervention and the sometimes dramatic reduction in symptoms need greater attention in research and practice. The aim of this case study is to explore the subjective experience of preparing for and undergoing DBS as a treatment for severe and treatment-refractory OCD and the experience of the impact of the treatment...
June 13, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29894385/tenofovir-and-tenofovir-diphosphate-concentrations-during-pregnancy-among-hiv-uninfected-women-using-oral-pre-exposure-prophylaxis
#17
Maria Pyra, Peter L Anderson, Craig W Hendrix, Renee Heffron, Kenneth Mugwanya, Jessica E Haberer, Katherine K Thomas, Connie Celum, Deborah Donnell, Mark A Marzinke, Elizabeth A Bukusi, Nelly R Mugo, Stephen Asiimwe, Elly Katabira, Jared M Baeten
OBJECTIVES: Pregnancy is a time of increased HIV acquisition risk and pregnancy reduces concentrations of antiretrovirals used for treatment. We assessed whether pregnancy lowers concentrations of tenofovir (TFV) and tenofovir-diphosphate (TFV-DP) among HIV-uninfected women using oral pre-exposure prophylaxis (PrEP). METHODS: We analyzed data from an open-label PrEP study, comparing concentrations of TFV in plasma and TFV-DP in dried blood spots (DBS) among 37 pregnant women and 97 non-pregnant women...
June 11, 2018: AIDS
https://www.readbyqxmd.com/read/29893711/frequency-dependent-antidromic-activation-in-thalamocortical-relay-neurons-effects-of-synaptic-inputs
#18
Guosheng Yi, Warren M Grill
OBJECTIVE: Deep brain stimulation (DBS) generates action potentials (APs) in presynaptic axons and fibers of passage. The APs may be antidromically propagated to invade the cell body and / or orthodromically transmitted to downstream structures, thereby affecting widespread targets distant from the electrode. Activation of presynaptic terminals also causes trans-synaptic effects, which in turn alter the excitability of the post-synaptic neurons. Our aim was to determine how synaptic inputs affect the antidromic invasion of the cell body...
June 12, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29890276/both-dbs-and-thalamotomy-in-a-13-year-old-patient-with-primary-dystonia-a-case-report
#19
Hai Lin, Xiao-Dong Cai, Dou-Dou Zhang, Jia-Li Liu, Wei-Ping Li
BACKGROUND: Primary dystonia is a neurological disease with the characteristics of abnormal, involuntary twisting and turning movements, which greatly affects life quality of patients. Treatments for dystonia consist of oral medications, botulinum neurotoxin injections, physical therapy and surgeries. For medication-refractory dystonia, surgeries, especially deep brain stimulation (DBS), are the optimal option. CASE DESCRIPTION: the patient was a 13-year-old boy suffering from extremely severe primary dystonia, with a BFMDRS-M score of 118 and a TWSTRS-S score of 29...
June 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29887826/anatomical-correlates-of-uncontrollable-laughter-with-unilateral-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#20
Yonglu Huang, Joshua P Aronson, Julie G Pilitsis, Lucy Gee, Jennifer Durphy, Eric Steven Molho, Adolfo Ramirez-Zamora
Introduction: Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for the management of motor complications in Parkinson's disease. Uncontrollable laughter has been reported as a rare side effect of STN stimulation. The precise mechanism responsible for this unique phenomenon remains unclear. We examined in detail the DBS electrode position and stimulation parameters in two patients with uncontrollable laughter during programming after STN-DBS surgery and illustrated the anatomical correlates of the acute mood changes with STN stimulation...
2018: Frontiers in Neurology
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