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https://www.readbyqxmd.com/read/27902311/the-ubiquitin-ligase-e6ap-mediates-nonproteolytic-polyubiquitylation-of-%C3%AE-catenin-independent-of-the-e6-oncoprotein
#1
Yael Kuslansky, Sophia Sominsky, Anna Jackman, Cristina Gamell, Brendon J Monahan, Ygal Haupt, Rina Rosin-Arbesfeld, Levana Sherman
Recently we showed that the ubiquitin ligase E6AP stabilizes β-catenin and activates its transcriptional activity. These activities were enhanced by the human papillomavirus (HPV) E6 protein. In the present study we explored the function of E6AP that increases β-catenin stabilization and transcriptional activation. Here we report that E6AP interacts with β-catenin and mediates its nonproteolytic ubiquitylation, as evidenced in transiently transfected cell-based, and in vitro reconstitution ubiquitylation assays...
October 7, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27890522/design-and-challenges-of-a-randomized-clinical-trial-of-medical-expulsive-therapy-tamsulosin-for-urolithiasis-in-the-emergency-department
#2
Pamela K Burrows, Judd E Hollander, Allan B Wolfson, Michael C Kurz, Lorna Richards, Sara DiFiore, Phillip Watts, Nivedita Patkar, Jeremy Brown, Stephen Jackman, Ziya Kirkali, John W Kusek, Chloe Michel, Andrew C Meltzer
Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy...
November 23, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27867795/magnetic-reconnection-in-saturn-s-magnetotail-a-comprehensive-magnetic-field-survey
#3
A W Smith, C M Jackman, M F Thomsen
Reconnection within planetary magnetotails is responsible for locally energizing particles and changing the magnetic topology. Its role in terms of global magnetospheric dynamics can involve changing the mass and flux content of the magnetosphere. We have identified reconnection related events in spacecraft magnetometer data recorded during Cassini's exploration of Saturn's magnetotail. The events are identified from deflections in the north-south component of the magnetic field, significant above a background level...
April 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27867794/the-impact-of-an-icme-on-the-jovian-x-ray-aurora
#4
William R Dunn, Graziella Branduardi-Raymont, Ronald F Elsner, Marissa F Vogt, Laurent Lamy, Peter G Ford, Andrew J Coates, G Randall Gladstone, Caitriona M Jackman, Jonathan D Nichols, I Jonathan Rae, Ali Varsani, Tomoki Kimura, Kenneth C Hansen, Jamie M Jasinski
We report the first Jupiter X-ray observations planned to coincide with an interplanetary coronal mass ejection (ICME). At the predicted ICME arrival time, we observed a factor of ∼8 enhancement in Jupiter's X-ray aurora. Within 1.5 h of this enhancement, intense bursts of non-Io decametric radio emission occurred. Spatial, spectral, and temporal characteristics also varied between ICME arrival and another X-ray observation two days later. Gladstone et al. (2002) discovered the polar X-ray hot spot and found it pulsed with 45 min quasiperiodicity...
March 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27860194/description-and-student-self-evaluation-of-a-pilot-small-group-learning-and-integrated-simulation-program-for-medical-students-in-the-first-clinical-year
#5
M R Levinson, D Kelly, K Zahariou, M Johnson, C Jackman, Sara Mackenzie
INTRODUCTION: Contemporary education for medical students should be student centered, integrated and contextualized. Small group learning promotes clinical reasoning and skills for lifelong learning. Simulation can provide experiential learning in a safe and controlled environment. We developed a weekly integrated problem based learning and simulation program (IPS) over two semesters in the first clinical year to augment clinical placement experience and contextualize theory into work relevant practice...
November 17, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27859333/reduced-mhc-alloimmunization-and-partial-tolerance-protection-with-pathogen-reduction-of-whole-blood
#6
Rachael P Jackman, Marcus O Muench, Heather Inglis, John W Heitman, Susanne Marschner, Raymond P Goodrich, Philip J Norris
BACKGROUND: Allogeneic blood transfusion can result in an immune response against major histocompatibility complex (MHC) antigens, potentially complicating future transfusions or transplants. We previously demonstrated that pathogen reduction of platelet-rich plasma (PRP) with riboflavin and ultraviolet light (UV+R) can prevent alloimmunization in mice. A similar pathogen-reduction treatment is currently under development for the treatment of whole blood using riboflavin and a higher dose of UV light...
November 18, 2016: Transfusion
https://www.readbyqxmd.com/read/27854504/a-roundtable-discussion-wireless-technology-poses-unique-challenges-for-healthcare
#7
Mary K Logan, H Stephen Berger, Shawn Jackman, Ira Keltz, Julie Knapp, Nickolas LaSorte, Robert Sayle, Calvin Sproul, Don Witters, Ali Youssef
No abstract text is available yet for this article.
September 2016: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/27854500/dispelling-wireless-technology-myths-and-developing-a-roadmap-for-success
#8
Shawn Jackman
No abstract text is available yet for this article.
September 2016: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/27848254/comparing-initial-diagnostic-excision-biopsy-of-cutaneous-malignant-melanoma-in-primary-versus-secondary-care-a-study-of-irish-national-data
#9
Sarah M Doherty, Louise M Jackman, John F Kirwan, Deirdre Dunne, Kieran G O'Connor, John M Rouse
BACKGROUND: The incidence of melanoma is rising worldwide. Current Irish guidelines from the National Cancer Control Programme state suspicious pigmented lesions should not be removed in primary care. There are conflicting guidelines and research advising who should remove possible melanomas. OBJECTIVES: To determine whether initial diagnostic excision biopsy of cutaneous malignant melanoma in primary versus secondary care leads to poorer survival. METHODS: Analysis of data comprising 7116 cases of cutaneous malignant melanoma from the National Cancer Registry Ireland between January 2002 and December 2011...
November 16, 2016: European Journal of General Practice
https://www.readbyqxmd.com/read/27792317/stealth-immune-properties-of-graphene-oxide-enabled-by-surface-bound-complement-factor-h
#10
Jason Nathaniel Belling, Joshua Alexander Jackman, Saziye Yorulmaz Avsar, Jae Hyeon Park, Yan Wang, Michael G Potroz, Abdul Rahim Ferhan, Paul S Weiss, Nam-Joon Cho
With mounting evidence that nanomaterials can trigger adverse innate immune responses such as complement activation, there is increasing attention to the development of strategies that mask the complement-activating properties of nanomaterials. The current gold standard to reduce complement activation of nanomaterials is the covalent attachment of polymer coatings on nanomaterial surfaces, even though this strategy provides only moderate protection against complement activation. Akin to protein coronas that form on nanomaterial surfaces in physiological fluids, noncovalent strategies based on protein adsorption would offer a simplified, biomimetic approach to mitigate complement activation...
October 28, 2016: ACS Nano
https://www.readbyqxmd.com/read/27741396/polycationic-nanofibers-for-nucleic-acid-scavenging
#11
Jennifer Gamboa Jackman, Hemraj Juwarker, Luke P Poveromo, Howard Levinson, Kam W Leong, Bruce A Sullenger
Dying cells release nucleic acids (NA) and NA-containing complexes that activate inflammatory pathways of immune cells. Sustained activation of these pathways contributes to chronic inflammation frequently encountered in autoimmune and inflammatory diseases. In this study, grafting of cationic polymers onto a nanofibrous mesh enabled local scavenging of negatively charged pro-inflammatory molecules in the extracellular space. Nucleic acid scavenging nanofibers (NASFs) formed from poly(styrene-alt-maleic anhydride) conjugated with 1...
October 14, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27730014/national-institute-of-biomedical-imaging-and-bioengineering-point-of-care-technology-research-network-advancing-precision-medicine
#12
Penny Ford Carleton, Steven Schachter, John A Parrish, John M Collins, J Benjamin Crocker, Ronald F Dixon, Susan Edgman-Levitan, Kent B Lewandrowski, James E Stahl, Catherine Klapperich, Mario Cabodi, Charlotte A Gaydos, Anne M Rompalo, Yukari Manabe, Tza-Huei Wang, Richard Rothman, Chris D Geddes, Lea Widdice, Joany Jackman, Rishi A Mathura, Tiffani Bailey Lash
To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27723557/dynamic-culture-yields-engineered-myocardium-with-near-adult-functional-output
#13
Christopher P Jackman, Aaron L Carlson, Nenad Bursac
Engineered cardiac tissues hold promise for cell therapy and drug development, but exhibit inadequate function and maturity. In this study, we sought to significantly improve the function and maturation of rat and human engineered cardiac tissues. We developed dynamic, free-floating culture conditions for engineering "cardiobundles", 3-dimensional cylindrical tissues made from neonatal rat cardiomyocytes or human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) embedded in fibrin-based hydrogel. Compared to static culture, 2-week dynamic culture of neonatal rat cardiobundles significantly increased expression of sarcomeric proteins, cardiomyocyte size (∼2...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27663274/visualization-of-kiss1-neuron-distribution-using-a-kiss1-cre-transgenic-mouse
#14
Shel Hwa Yeo, Victoria Kyle, Paul G Morris, Sophie Jackman, Lydia Sinnett-Smith, Maria Schacker, Chen Chen, William H Colledge
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurons are found in two locations in the rodent hypothalamus; one in the arcuate (ARC) and another in the RP3V region which includes the anteroventral periventricular (AVPV) nucleus. Detailed mapping of the fibre distribution of Kiss1 neurons will help in understanding the action of these neurons in other regions of the brain. We have generated a transgenic mouse in which the Kiss1 coding region has been disrupted by a CRE-GFP transgene so that expression of the CRE recombinase protein is driven from the Kiss1 promoter...
September 24, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27632164/assembly-of-the-complete-sitka-spruce-chloroplast-genome-using-10x-genomics-gemcode-sequencing-data
#15
Lauren Coombe, René L Warren, Shaun D Jackman, Chen Yang, Benjamin P Vandervalk, Richard A Moore, Stephen Pleasance, Robin J Coope, Joerg Bohlmann, Robert A Holt, Steven J M Jones, Inanc Birol
The linked read sequencing library preparation platform by 10X Genomics produces barcoded sequencing libraries, which are subsequently sequenced using the Illumina short read sequencing technology. In this new approach, long fragments of DNA are partitioned into separate micro-reactions, where the same index sequence is incorporated into each of the sequencing fragment inserts derived from a given long fragment. In this study, we exploited this property by using reads from index sequences associated with a large number of reads, to assemble the chloroplast genome of the Sitka spruce tree (Picea sitchensis)...
2016: PloS One
https://www.readbyqxmd.com/read/27625900/predicting-improvement-in-writer-s-cramp-symptoms-following-botulinum-neurotoxin-injection-therapy
#16
Mallory Jackman, Mehdi Delrobaei, Fariborz Rahimi, S Farokh Atashzar, Mahya Shahbazi, Rajni Patel, Mandar Jog
INTRODUCTION: Writer's cramp is a specific focal hand dystonia causing abnormal posturing and tremor in the upper limb. The most popular medical intervention, botulinum neurotoxin type A (BoNT-A) therapy, is variably effective for 50-70% of patients. BoNT-A non-responders undergo ineffective treatment and may experience significant side effects. Various assessments have been used to determine response prediction to BoNT-A, but not in the same population of patients. METHODS: A comprehensive assessment was employed to measure various symptom aspects...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27616067/influence-of-membrane-surface-charge-on-adsorption-of-complement-proteins-onto-supported-lipid-bilayers
#17
Saziye Yorulmaz, Joshua A Jackman, Walter Hunziker, Nam-Joon Cho
The complement system is an important part of the innate immune response, and there is great interest in understanding how complement proteins interact with lipid membrane interfaces, especially in the context of recognizing foreign particulates (e.g., liposomal nanomedicines). Herein, a supported lipid bilayer platform was employed in order to investigate the effect of membrane surface charge (positive, negative, or neutral) on the adsorption of three complement proteins. Quartz crystal microbalance-dissipation (QCM-D) experiments measured the real-time kinetics and total uptake of protein adsorption onto supported lipid bilayers...
August 22, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27610291/cassini-observations-of-ionospheric-plasma-in-saturn-s-magnetotail-lobes
#18
M Felici, C S Arridge, A J Coates, S V Badman, M K Dougherty, C M Jackman, W S Kurth, H Melin, D G Mitchell, D B Reisenfeld, N Sergis
Studies of Saturn's magnetosphere with the Cassini mission have established the importance of Enceladus as the dominant mass source for Saturn's magnetosphere. It is well known that the ionosphere is an important mass source at Earth during periods of intense geomagnetic activity, but lesser attention has been dedicated to study the ionospheric mass source at Saturn. In this paper we describe a case study of data from Saturn's magnetotail, when Cassini was located at ≃ 2200 h Saturn local time at 36 R S from Saturn...
January 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27602042/evolution-of-specialization-of-cassida-rubiginosa-on-cirsium-arvense-compositae-cardueae
#19
Michael G Cripps, Sarah D Jackman, Cristina Roquet, Chikako van Koten, Michael Rostás, Graeme W Bourdôt, Alfonso Susanna
The majority of herbivorous insects are specialized feeders restricted to a plant family, genus, or species. The evolution of specialized insect-plant interactions is generally considered to be a result of trade-offs in fitness between possible hosts. Through the course of natural selection, host plants that maximize insect fitness should result in optimal, specialized, insect-plant associations. However, the extent to which insects are tracking plant phylogeny or key plant traits that act as herbivore resistance or acceptance characters is uncertain...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27555650/a-single-origin-of-extreme-matrotrophy-in-african-mabuyine-skinks
#20
Margarita Metallinou, Jeffrey L Weinell, Benjamin R Karin, Werner Conradie, Philipp Wagner, Andreas Schmitz, Todd R Jackman, Aaron M Bauer
Most mammals and approximately 20% of squamates (lizards and snakes) are viviparous, whereas all crocodilians, birds and turtles are oviparous. Viviparity evolved greater than 100 times in squamates, including multiple times in Mabuyinae (Reptilia: Scincidae), making this group ideal for studying the evolution of nutritional patterns associated with viviparity. Previous studies suggest that extreme matrotrophy, the support of virtually all of embryonic development by maternal nutrients, evolved as many as three times in Mabuyinae: in Neotropical Mabuyinae (63 species), Eumecia (2 species; Africa) and Trachylepis ivensii (Africa)...
August 2016: Biology Letters
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