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Jennifer Gamboa Jackman, Hemraj Juwarker, Luke P Poveromo, Howard Levinson, Kam W Leong, Bruce A Sullenger
Dying cells release nucleic acids (NA) and NA-containing complexes that activate inflammatory pathways of immune cells. Sustained activation of these pathways contributes to chronic inflammation frequently encountered in autoimmune and inflammatory diseases. In this study, grafting of cationic polymers onto a nanofibrous mesh enabled local scavenging of negatively charged pro-inflammatory molecules in the extracellular space. Nucleic acid scavenging nanofibers (NASFs) formed from poly(styrene-alt-maleic anhydride) conjugated with 1...
October 14, 2016: Biomacromolecules
Penny Ford Carleton, Steven Schachter, John A Parrish, John M Collins, J Benjamin Crocker, Ronald F Dixon, Susan Edgman-Levitan, Kent B Lewandrowski, James E Stahl, Catherine Klapperich, Mario Cabodi, Charlotte A Gaydos, Anne M Rompalo, Yukari Manabe, Tza-Huei Wang, Richard Rothman, Chris D Geddes, Lea Widdice, Joany Jackman, Rishi A Mathura, Tiffani Bailey Lash
To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Christopher P Jackman, Aaron L Carlson, Nenad Bursac
Engineered cardiac tissues hold promise for cell therapy and drug development, but exhibit inadequate function and maturity. In this study, we sought to significantly improve the function and maturation of rat and human engineered cardiac tissues. We developed dynamic, free-floating culture conditions for engineering "cardiobundles", 3-dimensional cylindrical tissues made from neonatal rat cardiomyocytes or human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) embedded in fibrin-based hydrogel. Compared to static culture, 2-week dynamic culture of neonatal rat cardiobundles significantly increased expression of sarcomeric proteins, cardiomyocyte size (∼2...
December 2016: Biomaterials
Shel Hwa Yeo, Victoria Kyle, Paul G Morris, Sophie Jackman, Lydia Sinnett-Smith, Maria Schacker, Chen Chen, William H Colledge
Kisspeptin neuropeptides are encoded by the Kiss1 gene and play a critical role in the regulation of the mammalian reproductive axis. Kiss1 neurons are found in two locations in the rodent hypothalamus; one in the arcuate (ARC) and another in the RP3V region which includes the anteroventral periventricular (AVPV) nucleus. Detailed mapping of the fibre distribution of Kiss1 neurons will help in understanding the action of these neurons in other regions of the brain. We have generated a transgenic mouse in which the Kiss1 coding region has been disrupted by a CRE-GFP transgene so that expression of the CRE recombinase protein is driven from the Kiss1 promoter...
September 24, 2016: Journal of Neuroendocrinology
Lauren Coombe, René L Warren, Shaun D Jackman, Chen Yang, Benjamin P Vandervalk, Richard A Moore, Stephen Pleasance, Robin J Coope, Joerg Bohlmann, Robert A Holt, Steven J M Jones, Inanc Birol
The linked read sequencing library preparation platform by 10X Genomics produces barcoded sequencing libraries, which are subsequently sequenced using the Illumina short read sequencing technology. In this new approach, long fragments of DNA are partitioned into separate micro-reactions, where the same index sequence is incorporated into each of the sequencing fragment inserts derived from a given long fragment. In this study, we exploited this property by using reads from index sequences associated with a large number of reads, to assemble the chloroplast genome of the Sitka spruce tree (Picea sitchensis)...
2016: PloS One
Mallory Jackman, Mehdi Delrobaei, Fariborz Rahimi, S Farokh Atashzar, Mahya Shahbazi, Rajni Patel, Mandar Jog
INTRODUCTION: Writer's cramp is a specific focal hand dystonia causing abnormal posturing and tremor in the upper limb. The most popular medical intervention, botulinum neurotoxin type A (BoNT-A) therapy, is variably effective for 50-70% of patients. BoNT-A non-responders undergo ineffective treatment and may experience significant side effects. Various assessments have been used to determine response prediction to BoNT-A, but not in the same population of patients. METHODS: A comprehensive assessment was employed to measure various symptom aspects...
2016: Tremor and Other Hyperkinetic Movements
Saziye Yorulmaz, Joshua A Jackman, Walter Hunziker, Nam-Joon Cho
The complement system is an important part of the innate immune response, and there is great interest in understanding how complement proteins interact with lipid membrane interfaces, especially in the context of recognizing foreign particulates (e.g., liposomal nanomedicines). Herein, a supported lipid bilayer platform was employed in order to investigate the effect of membrane surface charge (positive, negative, or neutral) on the adsorption of three complement proteins. Quartz crystal microbalance-dissipation (QCM-D) experiments measured the real-time kinetics and total uptake of protein adsorption onto supported lipid bilayers...
August 22, 2016: Colloids and Surfaces. B, Biointerfaces
M Felici, C S Arridge, A J Coates, S V Badman, M K Dougherty, C M Jackman, W S Kurth, H Melin, D G Mitchell, D B Reisenfeld, N Sergis
Studies of Saturn's magnetosphere with the Cassini mission have established the importance of Enceladus as the dominant mass source for Saturn's magnetosphere. It is well known that the ionosphere is an important mass source at Earth during periods of intense geomagnetic activity, but lesser attention has been dedicated to study the ionospheric mass source at Saturn. In this paper we describe a case study of data from Saturn's magnetotail, when Cassini was located at ≃ 2200 h Saturn local time at 36 R S from Saturn...
January 2016: Journal of Geophysical Research. Space Physics
Michael G Cripps, Sarah D Jackman, Cristina Roquet, Chikako van Koten, Michael Rostás, Graeme W Bourdôt, Alfonso Susanna
The majority of herbivorous insects are specialized feeders restricted to a plant family, genus, or species. The evolution of specialized insect-plant interactions is generally considered to be a result of trade-offs in fitness between possible hosts. Through the course of natural selection, host plants that maximize insect fitness should result in optimal, specialized, insect-plant associations. However, the extent to which insects are tracking plant phylogeny or key plant traits that act as herbivore resistance or acceptance characters is uncertain...
2016: Frontiers in Plant Science
Margarita Metallinou, Jeffrey L Weinell, Benjamin R Karin, Werner Conradie, Philipp Wagner, Andreas Schmitz, Todd R Jackman, Aaron M Bauer
Most mammals and approximately 20% of squamates (lizards and snakes) are viviparous, whereas all crocodilians, birds and turtles are oviparous. Viviparity evolved greater than 100 times in squamates, including multiple times in Mabuyinae (Reptilia: Scincidae), making this group ideal for studying the evolution of nutritional patterns associated with viviparity. Previous studies suggest that extreme matrotrophy, the support of virtually all of embryonic development by maternal nutrients, evolved as many as three times in Mabuyinae: in Neotropical Mabuyinae (63 species), Eumecia (2 species; Africa) and Trachylepis ivensii (Africa)...
August 2016: Biology Letters
S Farokh Atashzar, Mahya Shahbazi, Christopher Ward, Olivia Samotus, Mehdi Delrobaei, Fariborz Rahimi, Jack Lee, Mallory Jackman, Mandar Jog, Rajni Patel
Abnormality of sensorimotor integration in the basal ganglia and cortex has been reported in the literature for patients with task-specific focal hand dystonia (FHD). In this study, we investigate the effect of manipulation of kinesthetic input in people living with writer's cramp disorder (a major form of FHD). For this purpose, severity of dystonia is studied for 11 participants while the symptoms of 7 participants have been tracked during 5 sessions of assessment and Botulinum toxin injection (BoNT-A) therapy (one of the current suggested therapies for dystonia)...
August 19, 2016: IEEE Transactions on Haptics
Jackman C Eschenroeder, James H Roberts
The rock bass (Ambloplites rupestris) is a popular sport-fish native to the Mississippi and Great Lakes basins of North America. The species has been widely introduced outside its native range, including into Atlantic-slope streams of Virginia where it may hybridize with an imperiled, similar-looking congener, the Roanoke bass (Ambloplites cavifrons). In this study, we identified and evaluated novel molecular markers to facilitate identification of these species and study the extent of hybridization. Using molecular libraries developed from A...
October 2016: Molecular Biology Reports
Yicheng Long, Maria G Abad, Erik D Olson, Elisabeth Y Carrillo, Jane E Jackman
The superfamily of 3'-5' polymerases synthesize RNA in the opposite direction to all other DNA/RNA polymerases, and its members include eukaryotic tRNA(His) guanylyltransferase (Thg1), as well as Thg1-like proteins (TLPs) of unknown function that are broadly distributed, with family members in all three domains of life. Dictyostelium discoideum encodes one Thg1 and three TLPs (DdiTLP2, DdiTLP3 and DdiTLP4). Here, we demonstrate that depletion of each of the genes results in a significant growth defect, and that each protein catalyzes a unique biological reaction, taking advantage of specialized biochemical properties...
September 30, 2016: Nucleic Acids Research
Michael Wagstaffe, Mark J Jackman, Karen L Syres, Alexander Generalov, Andrew G Thomas
The interaction of the ionic liquid [C4 C1 Im][BF4 ] with anatase TiO2 , a model photoanode material, has been studied using a combination of synchrotron radiation photoelectron spectroscopy and near-edge X-ray absorption fine structure spectroscopy. The system is of interest as a model for fundamental electrolyte-electrode and dye-sensitized solar cells. The initial interaction involves degradation of the [BF4 ](-) anion, resulting in incorporation of F into O vacancies in the anatase surface. At low coverages, [C4 C1 Im][BF4 ] is found to order at the anatase(101) surface via electrostatic attraction, with the imidazolium ring oriented 32±4° from the anatase TiO2 surface...
July 26, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Mahalia Jackman
This study evaluated the extent to which people living in Barbados, Guyana and Trinidad and Tobago believe that the anti-gay laws currently in place: (1) reflect moral standards; (2) stop the spread of homosexuality; (3) are important from a public health perspective; and (4) protect young people from abuse. Analysis reveals that demographics, religion, interpersonal contact and beliefs about the origin of homosexuality all influenced an individual's views on the usefulness of the anti-gay laws in these states, but the significance of their impacts varied substantially across the arguments...
July 22, 2016: Culture, Health & Sexuality
Clifford J Connell, Ruth Endacott, Jennifer A Jackman, Noelleen R Kiprillis, Louise M Sparkes, Simon J Cooper
BACKGROUND: Survival from in-hospital cardiac arrest is poor. Clinical features, including abnormal vital signs, often indicate patient deterioration prior to severe adverse events. Early warning systems and rapid response teams are commonly used to assist the health profession in the identification and management of the deteriorating patient. Education programs are widely used in the implementation of these systems. The effectiveness of the education is unknown. AIM: The aims of this study were to identify: (i) the evidence supporting educational effectiveness in the recognition and management of the deteriorating patient and (ii) outcome measures used to evaluate educational effectiveness...
September 2016: Nurse Education Today
Amanda J Redig, Daniel B Costa, Myriam Taibi, David Boucher, Bruce E Johnson, Pasi A Jänne, David M Jackman
No abstract text is available yet for this article.
September 1, 2016: JAMA Oncology
Ulrike Klueh, Caroline Czajkowski, Izabela Ludzinska, Yi Qiao, Jackman Frailey, Donald L Kreutzer
The accumulation of macrophages (MΦ) at the sensor-tissue interface is thought to be a major player in controlling tissue reactions and sensor performance in vivo. Nevertheless until recently no direct demonstration of the causal relationship between MΦ aggregation and loss of sensor function existed. Using a Continuous Glucose Monitoring (CGM) murine model we previously demonstrated that genetic deficiencies of MΦ or depletion of MΦ decreased MΦ accumulation at sensor implantation sites, which led to significantly enhanced CGM performance, when compared to normal mice...
December 15, 2016: Biosensors & Bioelectronics
Lindsay S Macnaughton, Stewart Jeromson, Oliver C Witard, Sarah R Jackman, David L Hamilton, Kevin D Tipton
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Amy L Miller, Michael Bowker, Andrés García-Trenco, Joseph Socci, Nia Richards, Graham Hutchings, Nicola Collis, James Earley, Simon Freakley, Robbie Burch, Mark Howard, Elad Gross, Andrzej Kotarba, Miron V Landau, James Anderson, Bert Weckhuysen, Simon Kondrat, Evgeny Naranov, John Mark Douthwaite, Ram Tiruvalam, Sarwat Iqbal, Luke Parker, Parag Shah, Ewa Nowicka, Wataru Ueda, Alessandro Piovano, Philip Landon, Nico Fischer, Christian Reece, Bruce Gates, Michael Lamb, Eoin Jackman, Tomasz Jakubek, Avelino Corma, Michael Claeys, Henrik Svengren, Cynthia Friend, David Lennon, Joshua Makepeace, Hazel Hunter, Haresh Manyar
No abstract text is available yet for this article.
July 4, 2016: Faraday Discussions
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