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Tara Nikonow Morgan, Mohammed Shahait, Avinash Maganty, Michael C Ost, Stephen V Jackman, Timothy D Averch, Michelle Jo Semins
BACKGROUND: To describe the clinical characteristics, infectious and kidney function patterns, and overall outcomes in a cohort of patients with staghorn calculi treated conservatively. METHODS: Staghorn calculi treated non-operatively between January 2009 and January 2017 were identified. A retrospective analysis was completed. RESULTS: Twenty-nine patients were identified with median age of 74 (IQR 61-81). Mean follow-up was 24 months. Fifty nine percent (17/29) had complete staghorn calculi with 6/29 (21%) bilateral...
March 1, 2018: Journal of Endourology
Joanna L Bowtell, Magni Mohr, Jonathan Fulford, Sarah R Jackman, Georgios Ermidis, Peter Krustrup, Katya N Mileva
Background: Caffeine has been shown to enhance exercise performance and capacity. The mechanisms remain unclear but are suggested to relate to adenosine receptor antagonism, resulting in increased central motor drive, reduced perception of effort, and altered peripheral processes such as enhanced calcium handling and extracellular potassium regulation. Our aims were to investigate how caffeine (i) affects knee extensor PCr kinetics and pH during repeated sets of single-leg knee extensor exercise to task failure and (ii) modulates the interplay between central and peripheral neural processes...
2018: Frontiers in Nutrition
Abdulkareem Afandi, Ashley Howkins, Ian W Boyd, Richard B Jackman
The inclusion of boron within nanodiamonds to create semiconducting properties would create a new class of applications in the field of nanodiamond electronics. Theoretical studies have differed in their conclusions as to whether nm-scale NDs would support a stable substitutional boron state, or whether such a state would be unstable, with boron instead aggregating or attaching to edge structures. In the present study detonation-derived NDs with purposefully added boron during the detonation process have been studied with a wide range of experimental techniques...
February 19, 2018: Scientific Reports
F Mazzola, J W Wells, A C Pakpour-Tabrizi, R B Jackman, B Thiagarajan, Ph Hofmann, J A Miwa
We demonstrate simultaneous quantization of conduction band (CB) and valence band (VB) states in silicon using ultrashallow, high-density, phosphorus doping profiles (so-called Si:P δ layers). We show that, in addition to the well-known quantization of CB states within the dopant plane, the confinement of VB-derived states between the subsurface P dopant layer and the Si surface gives rise to a simultaneous quantization of VB states in this narrow region. We also show that the VB quantization can be explained using a simple particle-in-a-box model, and that the number and energy separation of the quantized VB states depend on the depth of the P dopant layer beneath the Si surface...
January 26, 2018: Physical Review Letters
Griselle Leon, Elizabeth de Klerk, Josephine Ho, Michelle Jackman, Raylene A Reimer, Kimberly E Connors, Paola Luca
BACKGROUND: Childhood obesity places individuals at risk for a multitude of physical and mental health problems. The aim of this study was to assess the prevalence of obesity related comorbidities diagnosed prior to and after attending a tertiary care pediatric weight management clinic. METHODS: A cross sectional retrospective chart review of patients 2-17 years old seen in the weight management clinic at Alberta Children's Hospital from May 2012 to May 2014. RESULTS: A total of 199 patients were included in the review...
February 13, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Anja Kahl, Ismary Blanco, Katherine Jackman, Juhi Baskar, Harihar Milaganur Mohan, Reunet Rodney-Sandy, Sheng Zhang, Costantino Iadecola, Karin Hochrainer
Protein aggregation critically affects cell viability in neurodegenerative diseases, but whether this also occurs in ischemic brain injury remains elusive. Prior studies report the post-ischemic aggregation of ubiquitin, small ubiquitin-related modifier (SUMO) and ribosomes, however whether other proteins are also affected is unknown. Here we employed a proteomic approach to identify the insoluble, aggregated proteome after cerebral ischemia. Mice underwent transient middle cerebral artery occlusion or sham-surgery...
February 9, 2018: Scientific Reports
Leigh Perreault, Sean A Newsom, Allison Strauss, Anna Kerege, Darcy E Kahn, Kathleen A Harrison, Janet K Snell-Bergeon, Travis Nemkov, Angelo D'Alessandro, Matthew R Jackman, Paul S MacLean, Bryan C Bergman
BACKGROUND: Accumulation of diacylglycerol (DAG) and sphingolipids is thought to promote skeletal muscle insulin resistance by altering cellular signaling specific to their location. However,the subcellular localization of bioactive lipids in human skeletal muscle is largely unknown. METHODS: We evaluated subcellular localization of skeletal muscle DAGs and sphingolipids in lean individuals (n = 15), endurance-trained athletes (n = 16), and obese men and women with (n = 12) and without type 2 diabetes (n = 15)...
February 8, 2018: JCI Insight
Robert G Schaut, Matthew T Brewer, Kriscelle Mendoza, John Jackman, Balaji Narasimhan, Douglas E Jones
No abstract text is available yet for this article.
February 8, 2018: Vaccine
Robert G Schaut, Matthew T Brewer, Jesse M Hostetter, Kriscelle Mendoza, Julia E Vela-Ramirez, Sean M Kelly, John K Jackman, Giuseppe Dell'Anna, Joan M Howard, Balaji Narasimhan, Wen Zhou, Douglas E Jones
Traditionally, vaccination strategies require an initial priming vaccination followed by an antigen boost to generate adequate immunity. Here we describe vaccination against a self-peptide for reproductive sterilization utilizing a three-stage vaccine platform consisting of gonadotropin releasing hormone multiple antigenic peptide (GnRH-MAP) as a soluble injection coupled with subcutaneous administration of polyanhydride-immobilized GnRH-MAP and a cyto-exclusive implant containing GnRH-MAP dendrimer-loaded polyanhydride...
February 8, 2018: Vaccine
Jordon D Bosse, Raeann G Leblanc, Kasey Jackman, Ragnhildur I Bjarnadottir
Individuals in lesbian, gay, bisexual, and transgender communities experience several disparities in physical and mental health (eg, cardiovascular disease and depression), as well as difficulty accessing care that is compassionate and relevant to their unique needs. Access to care is compromised in part due to inadequate information systems that fail to capture identity data. Beginning in January 2018, meaningful use criteria dictate that electronic health records have the capability to collect data related to sexual orientation and gender identity of patients...
February 5, 2018: Computers, Informatics, Nursing: CIN
R M Foright, D M Presby, V D Sherk, D Kahn, L A Checkley, E D Giles, A Bergouignan, J A Higgins, M R Jackman, J O Hill, P S MacLean
Weight regain after weight loss is one of the most significant challenges to successful obesity treatment. Regular exercise has long been touted as a strategy for weight loss maintenance, but the lack of clear evidence in clinical trials has caused some to question its effectiveness. In this review, we present the arguments both questioning and in support of exercise as an obesity therapeutic. Our purpose is to bring clarity to the literature, present a unified perspective, and identify the gaps in knowledge that need to be addressed in future studies...
January 27, 2018: Physiology & Behavior
Sarah A Rawstron, Janelle M Jackman, Elena Serebro, Gail Johnson, Michael Cabbad, Kenneth Bromberg, Vasantha Kondamudi, Doug Sepkowitz, David Landman
No abstract text is available yet for this article.
January 23, 2018: Infection Control and Hospital Epidemiology
Christine Jackman, Ryan Waddell, Leon Fisher, Michael Ben-Meir, Gabriel Blecher, Gerard S Goh, Katie Walker
No abstract text is available yet for this article.
January 12, 2018: Emergency Medicine Australasia: EMA
Kabir Hassan Biswas, Joshua Alexander Jackman, Jae Hyeon Park, Jay T Groves, Nam-Joon Cho
The pathway of vesicle adsorption onto a solid support depends on the material composition of the underlying support, and there is significant interest in developing material-independent strategies to modulate the spectrum of vesicle-substrate interactions on a particular surface. Herein, using the quartz crystal microbalance-dissipation (QCM-D) technique, we systematically investigated how solution pH and membrane surface charge affect vesicle adsorption onto a silicon dioxide surface. While vesicle adsorption and spontaneous rupture to form complete supported lipid bilayer (SLBs) occurred in acidic conditions, it was discovered that a wide range of adsorption pathways occurred in alkaline conditions, including i) vesicle adsorption and spontaneous rupture to form complete SLBs, ii) vesicle adsorption and spontaneous rupture to form incomplete SLBs, iii) irreversible adsorption of intact vesicles, iv) reversible adsorption of intact vesicles; and v) negligible adsorption...
December 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Abdul Rahim Ferhan, Joshua A Jackman, Jae Hyeon Park, Nam-Joon Cho, Dong-Hwan Kim
The detection of cancer biomarkers represents an important aspect of cancer diagnosis and prognosis. Recently, the concept of liquid biopsy has been introduced whereby diagnosis and prognosis are performed by means of analyzing biological fluids obtained from patients to detect and quantify circulating cancer biomarkers. Unlike conventional biopsy whereby primary tumor cells are analyzed, liquid biopsy enables the detection of a wide variety of circulating cancer biomarkers, including microRNA (miRNA), circulating tumor DNA (ctDNA), proteins, exosomes and circulating tumor cells (CTCs)...
December 13, 2017: Advanced Drug Delivery Reviews
Jurriaan J J Gillissen, Joshua Alexander Jackman, Seyed R Tabaei, Nam-Joon Cho
The quartz crystal microbalance (QCM) is a surface-sensitive measurement technique to characterize adsorption processes at solid-fluid interfaces. While QCM measurements are routinely applied to study homogenous thin films, characterizing heterogeneous films of adsorbed particles remains challenging because QCM is sensitive to not only the mass of adsorbed particles but also that of hydrodynamically-coupled fluid. To extract information about adsorbed particles, it is necessary to model these complex hydrodynamic effects, however, current QCM models are restricted to the limit of either a very low surface coverage or to the extrapolated limit of saturation coverage...
December 14, 2017: Analytical Chemistry
Mary M Jackman, Siyeon Im, Seth R Bohman, Concordia C L Lo, Amanda L Garrity, Steven L Castle
The synthesis of functionalized nitriles via microwave-promoted radical fragmentations of cyclic O-phenyl oxime ethers is reported. A variety of radical traps can be employed, permitting the generation of diverse adducts via C-O, C-C, C-N, or C-X bond formation. Other salient features include a simple and practical protocol, very short reaction times, and the avoidance of metal catalysts and toxic cyanide reagents. The utility of this method is demonstrated by the ring-distortion of a steroid-derived substrate...
January 12, 2018: Chemistry: a European Journal
Tamás Fülöp, Réka Nemes, Tamás Mészáros, Rudolf Urbanics, Robbert Jan Kok, Joshua A Jackman, Nam-Joon Cho, Gert Storm, János Szebeni
The unique magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) have led to their increasing use in drug delivery and imaging applications. Some polymer-coated SPIONs, however, share with many other nanoparticles the potential of causing hypersensitivity reactions (HSRs) known as complement (C) activation-related pseudoallergy (CARPA). In order to explore the roles of iron core composition and particle surface coating in SPION-induced CARPA, we measured C activation by 6 different SPIONs in a human serum that is known to react to nanoparticles (NPs) with strong C activation...
January 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jurriaan J J Gillissen, Seyed R Tabaei, Joshua A Jackman, Nam-Joon Cho
Enclosed lipid bilayer structures, referred to as liposomes or lipid vesicles, have a wide range of biological functions, such as cellular signaling and membrane trafficking. The efficiency of cellular uptake of liposomes, a key step in many of these functions, is strongly dependent on the contact area between a liposome and a cell membrane, which is governed by the adhesion force w, the membrane bending energy κ, and the osmotic pressure Δp. Herein, we investigate the relationship between these forces and the physicochemical properties of the solvent, namely, the presence of glucose (a nonionic osmolyte)...
January 9, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ilya Y Shadrin, Brian W Allen, Ying Qian, Christopher P Jackman, Aaron L Carlson, Mark E Juhas, Nenad Bursac
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a "Cardiopatch" platform for 3D culture and maturation of hiPSC-CMs that after 5 weeks of differentiation show robust electromechanical coupling, consistent H-zones, I-bands, and evidence for T-tubules and M-bands. Cardiopatch maturation markers and functional output increase during culture, approaching values of adult myocardium...
November 28, 2017: Nature Communications
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