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https://www.readbyqxmd.com/read/29138256/low-neonatal-plasma-n-6-n-3-pufa-ratios-regulate-offspring-adipogenic-potential-and-condition-adult-obesity-resistance
#1
Michael C Rudolph, Matthew R Jackman, David M Presby, Julie A Houck, Patricia G Webb, Ginger C Johnson, Taylor K Soderborg, Becky A de la Houssaye, Ivana V Yang, Jacob E Friedman, Paul S MacLean
Adipose tissue expansion (ATE) progresses rapidly during postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues. The ratio of n-6 relative to n-3 polyunsaturated fatty acids (PUFA) is thought to regulate perinatal adipogenesis, but the cellular mechanisms and long-term effects are not well understood. We lowered the fetal and postnatal n-6/n-3 PUFA ratio exposure in wildtype offspring, under standard maternal dietary fat amounts, to test effects of low n-6/n-3 ratios on offspring adipogenesis and adipogenic potential...
November 14, 2017: Diabetes
https://www.readbyqxmd.com/read/29111680/indirect-nanoplasmonic-sensing-platform-for-monitoring-temperature-dependent-protein-adsorption
#2
Joshua Alexander Jackman, Abdul Rahim Ferhan, Bo Kyeong Yoon, Jae Hyeon Park, Vladimir P Zhdanov, Nam-Joon Cho
The development of highly surface-sensitive measurement approaches to monitor protein adsorption across different temperatures would advance understanding of how thermally activated processes contribute to the denaturation of adsorbed proteins. Herein, we established an indirect nanoplasmonic sensing approach to monitor the temperature-dependent adsorption and denaturation of bovine serum albumin (BSA) protein onto a silica-coated array of plasmonic gold nanodisks. A theoretical model was developed to explain how the denaturation of an individual, adsorbed protein molecule influences the localized surface plasmon resonance (LSPR) measurement response, and provided an analytical framework to estimate the effect of temperature-dependent protein denaturation on the corresponding adsorption kinetics...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29099335/generational-differences-in-internalized-transnegativity-and-psychological-distress-among-feminine-spectrum-transgender-people
#3
Kasey B Jackman, Curtis Dolezal, Walter O Bockting
PURPOSE: This study examined internalized transnegativity and psychological distress in two age groups of transgender individuals who identified their gender identity on the feminine spectrum (rather than congruent with their male sex assigned at birth). Due to greater visibility and acceptance of gender diversity in the United States, we hypothesized that internalized transnegativity would be lower in the younger compared with the older group, and that the younger generation would, therefore, report lower levels of psychological distress than the older generation...
November 3, 2017: LGBT Health
https://www.readbyqxmd.com/read/29097693/atmospheric-beacons-of-life-from-exoplanets-around-g-and-k-stars
#4
Vladimir S Airapetian, Charles H Jackman, Martin Mlynczak, William Danchi, Linda Hunt
The current explosion in detection and characterization of thousands of extrasolar planets from the Kepler mission, the Hubble Space Telescope, and large ground-based telescopes opens a new era in searches for Earth-analog exoplanets with conditions suitable for sustaining life. As more Earth-sized exoplanets are detected in the near future, we will soon have an opportunity to identify habitale worlds. Which atmospheric biosignature gases from habitable planets can be detected with our current capabilities? The detection of the common biosignatures from nitrogen-oxygen rich terrestrial-type exoplanets including molecular oxygen (O2), ozone (O3), water vapor (H2O), carbon dioxide (CO2), nitrous oxide (N2O), and methane (CH4) requires days of integration time with largest space telescopes, and thus are very challenging for current instruments...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093993/ancient-divergence-time-estimates-in-eutropis-rugifera-support-the-existence-of-pleistocene-barriers-on-the-exposed-sunda-shelf
#5
Benjamin R Karin, Indraneil Das, Todd R Jackman, Aaron M Bauer
Episodic sea level changes that repeatedly exposed and inundated the Sunda Shelf characterize the Pleistocene. Available evidence points to a more xeric central Sunda Shelf during periods of low sea levels, and despite the broad land connections that persisted during this time, some organisms are assumed to have faced barriers to dispersal between land-masses on the Sunda Shelf. Eutropis rugifera is a secretive, forest adapted scincid lizard that ranges across the Sunda Shelf. In this study, we sequenced one mitochondrial (ND2) and four nuclear (BRCA1, BRCA2, RAG1, and MC1R) markers and generated a time-calibrated phylogeny in BEAST to test whether divergence times between Sundaic populations of E...
2017: PeerJ
https://www.readbyqxmd.com/read/29089196/immediate-effect-of-a-functional-wrist-orthosis-for-children-with-cerebral-palsy-or-brain-injury-a-randomized-controlled-trial
#6
Michelle Jackman, Iona Novak, Natasha Lannin, Claire Galea
STUDY DESIGN: Two-group randomized controlled trial. INTRODUCTION: Upper limb orthoses worn during functional tasks are commonly used in pediatric neurologic rehabilitation, despite a paucity of high-level evidence. PURPOSE OF THE STUDY: The purpose of this study was to investigate if a customized functional wrist orthosis, when placed on the limb, leads to an immediate improvement in hand function for children with cerebral palsy or brain injury...
October 28, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29072750/nanoscale-conformal-films-of-graphitic-carbon-nitride-deposited-at-room-temperature-a-method-for-construction-of-heterojunction-devices
#7
Satyam A Ladva, William Travis, Raul Quesada-Cabrera, Martin Rosillo-Lopez, Abdulkareem Afandi, Yaomin Li, Richard B Jackman, Joseph C Bear, Ivan P Parkin, Christopher Blackman, Christoph G Salzmann, Robert G Palgrave
Graphitic carbon nitrides (GCNs) represent a family of 2D materials composed of carbon and nitrogen with variable amounts of hydrogen, used in a wide variety of applications. We report a method of room temperature thin film deposition which allows ordered GCN layers to be deposited on a very wide variety of substrates, including conductive glass, flexible plastics, nanoparticles and nano-structured surfaces, where they form a highly conformal coating on the nanoscale. Film thicknesses of below 20 nm are achievable...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29058893/detection-of-amphipathic-viral-peptide-on-screen-printed-electrodes-by-liposome-rupture-impact-voltammetry
#8
Muhammad Zafir Mohamad Nasir, Joshua A Jackman, Nam-Joon Cho, Adriano Ambrosi, Martin Pumera
Detection of infectious viruses and disease biomarkers is of utmost importance in clinical screening for effective identification and treatment of diseases. We demonstrate here the use of liposome rupture impact voltammetry for the qualitative detection of model amphipathic viral peptide on a screen-printed electrode. This novel, proof-of-concept method was proposed for the quick and reliable detection of viruses by nonfaradaic liposome rupture impact voltammetry with the aid of 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29032259/effect-of-evaporative-weathering-and-oil-sediment-interaction-on-the-fate-and-behavior-of-diluted-bitumen-in-marine-environments-part-2-the-water-accommodated-and-particle-laden-hydrocarbon-species-and-toxicity-of-the-aqueous-phase
#9
Zeyu Yang, Yujuan Hua, Fatemeh Mirnaghi, Bruce P Hollebone, Paula Jackman, Carl E Brown, Chun Yang, Keval Shah, Mike Landriault, Brian Chan
In this study, the water accommodated and particle-laden hydrocarbon species, and the toxicity of the aqueous phase after oil-sediment interactions by varying the weathering states of diluted bitumen (Cold Lake blend (CLB)), oil type from light to heavy, and sediment type. Compared to the original oils, the sediment-laden total petroleum hydrocarbons (TPH) contained fewer hydrocarbons in the carbon range <C10, comparable contents in C10-C16 range, higher contents in both the C16-C34 and >C34 range. Sediment-laden oil amounts generally decreased with an increased viscosity and asphaltene content of the test oils, as well as with increased sediment particle size...
October 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29021841/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#10
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29016841/2017%C3%A2-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#11
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016840/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation
#12
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28994623/exploring-functional-outcomes-and-allied-health-staffing-levels-in-an-inpatient-paediatric-rehabilitation-unit
#13
Penelope J Ireland, Amanda Francis, Shani Jackman, Kim McLennan
PURPOSE: This study provides data from a paediatric tertiary hospital on the length of stay, functional improvement and allied health workload for children and adolescents on active inpatient rehabilitation programs. METHODS: An audit was conducted of records of patients managed through an inpatient rehabilitation program at a 359 bed tertiary children's hospital in Brisbane, Australia between December 2014 and December 2015. Data relating to diagnosis, length of stay, functional change, occasions of allied health service and hours of patient attributable allied health professional time were collected...
October 10, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28993738/continuous-release-of-tumor-derived-factors-improves-the-modeling-of-cachexia-in-muscle-cell-culture
#14
Robert W Jackman, Jess Floro, Rei Yoshimine, Brian Zitin, Maythita Eiampikul, Kahlid El-Jack, Danielle N Seto, Susan C Kandarian
Cachexia is strongly associated with a poor prognosis in cancer patients but the biological trigger is unknown and therefore no therapeutics exist. The loss of skeletal muscle is the most deleterious aspect of cachexia and it appears to depend on secretions from tumor cells. Models for studying wasting in cell culture consist of experiments where skeletal muscle cells are incubated with medium conditioned by tumor cells. This has led to candidates for cachectic factors but some of the features of cachexia in vivo are not yet well-modeled in cell culture experiments...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28965340/acute-exercise-and-insulin-sensitivity-in-boys-a-time-course-study
#15
Emma J Cockcroft, Craig A Williams, Hayley Weaver, Amy O'Connor, Sarah R Jackman, Neil Armstrong, Alan R Barker
This study examined the time course of adaptions in insulin sensitivity (IS) in adolescent boys after acute high-intensity interval exercise (HIIE) and moderate-intensity exercise (MIE). Eight boys (15.1±0.4 y) completed three 3-day experimental trials in a randomised order: 1) 8×1 min cycling at 90% peak power with 75 s recovery (HIIE); 2) cycling at 90% of gas exchange threshold for a duration to match work during HIIE (MIE); and 3) rest (CON). Plasma [glucose] and [insulin] were measured before (PRE-Ex), 24 and 48 h post (24 h-POST, 48 h-POST) in a fasted state, and 40 min (POST-Ex) and 24 h (24 h-POST) post in response to an oral glucose tolerance test (OGTT)...
October 1, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28964734/behavioral-and-molecular-analyses-of-olfaction-mediated-avoidance-responses-of-rana-lithobates-catesbeiana-tadpoles-sensitivity-to-thyroid-hormones-estrogen-and-treated-municipal-wastewater-effluent
#16
Jody L Heerema, Kevin W Jackman, Rachel C Miliano, Linda Li, Tristan S M Zaborniak, Nik Veldhoen, Graham van Aggelen, Wayne J Parker, Gregory G Pyle, Caren C Helbing
Olfaction is critical for survival, facilitating predator avoidance and food location. The nature of the olfactory system changes during amphibian metamorphosis as the aquatic herbivorous tadpole transitions to a terrestrial, carnivorous frog. Metamorphosis is principally dependent on the action of thyroid hormones (THs), l-thyroxine (T4) and 3,5,3'-triiodothyronine (T3), yet little is known about their influence on olfaction during this phase of postembryonic development. We exposed Taylor Kollros stage I-XIII Rana (Lithobates) catesbeiana tadpoles to physiological concentrations of T4, T3, or 17-beta-estradiol (E2) for 48h and evaluated a predator cue avoidance response...
October 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28961637/the-hugh-jackman-effect-the-impact-of-celebrity-health-disclosure-on-skin-cancer-awareness
#17
George Rahmani, Adrian McArdle, John L Kelly
No abstract text is available yet for this article.
September 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28950101/tension-creates-an-endoreplication-wavefront-that-leads-regeneration-of-epicardial-tissue
#18
Jingli Cao, Jinhu Wang, Christopher P Jackman, Amanda H Cox, Michael A Trembley, Joseph J Balowski, Ben D Cox, Alessandro De Simone, Amy L Dickson, Stefano Di Talia, Eric M Small, Daniel P Kiehart, Nenad Bursac, Kenneth D Poss
Mechanisms that control cell-cycle dynamics during tissue regeneration require elucidation. Here we find in zebrafish that regeneration of the epicardium, the mesothelial covering of the heart, is mediated by two phenotypically distinct epicardial cell subpopulations. These include a front of large, multinucleate leader cells, trailed by follower cells that divide to produce small, mononucleate daughters. By using live imaging of cell-cycle dynamics, we show that leader cells form by spatiotemporally regulated endoreplication, caused primarily by cytokinesis failure...
September 25, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28943155/is-bone-density-associated-with-intervertebral-disc-pressure-in-healthy-and-degenerated-discs
#19
Paul M Fein, Alexander DelMonaco, Timothy M Jackman, Cameron Curtiss, Ali Guermazi, Glenn D Barest, Elise F Morgan
The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae, with emphasis on how this correspondence differs between healthy and degenerated IVDs. Bone density of the endplates and subchondral bone in regions adjacent to the anterior and posterior annulus fibrosus (aAF and pAF, respectively) and nucleus pulposus (NP) was measured via quantitative computed tomography (QCT) in 61 spine segments (T7-9, T9-11, T10-12; 71±14years)...
September 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28933837/quartz-crystal-microbalance-model-for-quantitatively-probing-the-deformation-of-adsorbed-particles-at-low-surface-coverage
#20
Jurriaan J J Gillissen, Joshua A Jackman, Seyed R Tabaei, Bo Kyeong Yoon, Nam-Joon Cho
Characterizing the deformation of nanoscale, soft-matter particulates at solid-liquid interfaces is a demanding task, and there are limited experimental options to perform quantitative measurements in a nonperturbative manner. Previous attempts, based on the quartz crystal microbalance (QCM) technique, focused on the high surface coverage regime and modeled the adsorbed particles as a homogeneous film, while not considering the coupling between particles and surrounding fluid and hence resulting in an underestimation of the known particle height...
November 7, 2017: Analytical Chemistry
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