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https://www.readbyqxmd.com/read/28943155/is-bone-density-associated-with-intervertebral-disc-pressure-in-healthy-and-degenerated-discs
#1
Paul M Fein, Alexander DelMonaco, Timothy M Jackman, Cameron Curtiss, Ali Guermazi, Glenn D Barest, Elise F Morgan
The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae, with emphasis on how this correspondence differs between healthy and degenerated IVDs. Bone density of the endplates and subchondral bone in regions adjacent to the anterior and posterior annulus fibrosus (aAF and pAF, respectively) and nucleus pulposus (NP) was measured via quantitative computed tomography (QCT) in 61 spine segments (T7-9, T9-11, T10-12; 71±14years)...
September 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28933837/a-quartz-crystal-microbalance-model-for-quantitatively-probing-the-deformation-of-adsorbed-particles-at-low-surface-coverage
#2
Jurriaan J J Gillissen, Joshua Alexander Jackman, Seyed R Tabaei, Bo Kyeong Yoon, Nam-Joon Cho
Characterizing the deformation of nanoscale, soft-matter particulates at solid-liquid interfaces is a demanding task, and there are limited experimental options to perform quantitative measurements in a non-perturbative manner. Previous attempts, based on the quartz crystal microbalance (QCM) technique, focused on the high surface coverage regime and modeled the adsorbed particles as a homogeneous film, while not considering the coupling between particles and surrounding fluid and hence resulting in an underestimation of the known particle height...
September 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28914401/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#3
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28911116/mechanistic-features-of-the-atypical-trna-m1g9-spout-methyltransferase-trm10
#4
Aiswarya Krishnamohan, Jane E Jackman
The tRNA m1G9 methyltransferase (Trm10) is a member of the SpoU-TrmD (SPOUT) superfamily of methyltransferases, and Trm10 homologs are widely conserved throughout Eukarya and Archaea. Despite possessing the trefoil knot characteristic of SPOUT enzymes, Trm10 does not share the same quaternary structure or key sequences with other members of the SPOUT family, suggesting a novel mechanism of catalysis. To investigate the mechanism of m1G9 methylation by Trm10, we performed a biochemical and kinetic analysis of Trm10 and variants with alterations in highly conserved residues, using crystal structures solved in the absence of tRNA as a guide...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28886009/tau-mediated-iron-export-prevents-ferroptotic-damage-after-ischemic-stroke
#5
Q-Z Tuo, P Lei, K A Jackman, X-L Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, P J Crouch, K Ganio, X-C Wang, L Pei, P A Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, A I Bush
Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate ischemia-reperfusion-related toxicity. Indeed, unilateral, transient middle cerebral artery occlusion (MCAO) suppressed hemispheric tau and increased iron levels in young (3-month-old) mice and rats. Wild-type mice were protected by iron-targeted interventions: ceruloplasmin and amyloid precursor protein ectodomain, as well as ferroptosis inhibitors...
September 8, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28882778/the-efficacy-of-tadalafil-daily-versus-on-demand-in-the-treatment-of-erectile-dysfunction-a-systematic-review-and-meta-analysis
#6
REVIEW
Utsav K Bansal, Cameron Jones, Thomas W Fuller, Charles Wessel, Stephen Jackman
We present a review comparing the use of tadalafil daily versus on-demand for erectile dysfunction. We examined randomized controlled trials and observational studies that examined the use of tadalafil for at least 8 weeks of follow-up with the primary outcome of International Index for Erectile Dysfunction- Erectile Function domain (IIEF-EF). Eight studies were identified that examined the desired dosing regimens. Of these, six studies included the primary endpoint of twelve weeks. Those patients taking tadalafil daily for 12 weeks scored on average 1...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/28861585/a-model-derived-from-hydrodynamic-simulations-for-extracting-the-size-of-spherical-particles-from-the-quartz-crystal-microbalance
#7
Jurriaan J J Gillissen, Seyed R Tabaei, Joshua A Jackman, Nam-Joon Cho
One challenging aspect of quartz crystal microbalance (QCM) measurements is the characterization of adsorbed particles as the change in resonance frequency (Δf) is proportional not only to the inertia of the adsorbed layer but also to that of the hydrodynamically coupled fluid. Herein, by solving numerically the Navier-Stokes equations, we scrutinize Δf for sparsely deposited, rigid spherical particles that are firmly attached to an oscillating surface. The analysis is shown to be applicable to adsorbed, small unilamellar vesicles (SUVs) of controlled size under experimental conditions in which adhesion-induced vesicle deformation is negligible...
September 1, 2017: Analyst
https://www.readbyqxmd.com/read/28841626/disclosure-of-financial-conflicts-of-interest-in-plastic-and-reconstructive-surgery
#8
Edward A Luce, Carye A Jackman
BACKGROUND: Recent articles in the scientific literature have expressed concerns about financial conflicts of interest in the profession of medicine in general and the specialty of plastic surgery in particular. Disclosure of financial ties to industry has been regarded as an address of a possible bias. The policies of medical journals places responsibility on authors for self-reporting of financial conflicts of interest, yet underreporting of conflicts of interest has occurred. The investigative hypothesis was that authors in the plastic surgery literature, in particular, Plastic and Reconstructive Surgery, underreported financial conflicts of interest...
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28811155/assessing-changes-in-quality-of-life-and-independent-living-and-working-levels-among-agrability-farmers-and-ranchers-with-disabilities
#9
Robert J Fetsch, Danielle M Jackman, Christina L Collins
BACKGROUND: While emerging research has focused on quality of life (QOL) levels among farmers and ranchers with disabilities, much work is still needed on this largely understudied population. The AgrAbility Project, a USDA initiative, offers pragmatic solutions to increase farmers and ranchers with disabilities' QOL and ability to work and live independently (ILW). OBJECTIVES: To assess pretest-posttest changes in farmers and ranchers with disabilities' ILW and QOL levels after participating in AgrAbility, to identify demographic predictors of ILW and QOL (e...
August 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28809547/quantitative-evaluation-of-viral-protein-binding-to-phosphoinositide-receptors-and-pharmacological-inhibition
#10
Seong-Oh Kim, Joshua A Jackman, Menashe Elazar, Sang-Joon Cho, Jeffrey S Glenn, Nam-Joon Cho
There is significant interest in developing analytical methods to characterize molecular recognition events between proteins and phosphoinositides, which are a medically important class of carbohydrate-functionalized lipids. Within this scope, one area of high priority involves quantitatively evaluating drug candidates that pharmacologically inhibit protein-phosphoinositide interactions. As full-length proteins are often difficult to produce, establishing methods to study these interactions with shorter, bioactive peptides would be advantageous...
August 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28694346/a-systematic-review-of-the-worldwide-prevalence-of-survivors-of-poliomyelitis-reported-in-31-studies
#11
Kelly M Jones, Shivanthi Balalla, Alice Theadom, Gordon Jackman, Valery L Feigin
BACKGROUND: Accurate prevalence figures estimating the number of survivors of poliomyelitis (disease causing acute flaccid paralysis) following poliovirus infection are not available. We aim to undertake a systematic review of all literature concerning the prevalence of survivors of poliomyelitis. METHODS: Electronic databases were searched from 1900 up to May 2016 for peer-reviewed studies using a population-based approach witha defined denominator and some form of diagnostic or clinical verification of polio...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28683197/immobilization-strategies-for-functional-complement-convertase-assembly-at-lipid-membrane-interfaces
#12
Saziye Yorulmaz Avsar, Joshua A Jackman, Min Chul Kim, Bo Kyeong Yoon, Walter Hunziker, Nam-Joon Cho
The self-assembly formation of complement convertases-essential biomacromolecular complexes that amplify innate immune responses-is triggered by protein adsorption. Herein, a supported lipid bilayer platform was utilized to investigate the effects of covalent and noncovalent tethering strategies on the self-assembly of alternative pathway C3 convertase components, starting with C3b protein adsorption followed bythe addition of factors B and D. Quartz crystal microbalance-dissipation (QCM-D) experiments measured the real-time kinetics of convertase assembly onto supported lipid bilayers...
July 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28644423/probing-the-interaction-of-dielectric-nanoparticles-with-supported-lipid-membrane-coatings-on-nanoplasmonic-arrays
#13
Abdul Rahim Ferhan, Gamaliel Junren Ma, Joshua A Jackman, Tun Naw Sut, Jae Hyeon Park, Nam-Joon Cho
The integration of supported lipid membranes with surface-based nanoplasmonic arrays provides a powerful sensing approach to investigate biointerfacial phenomena at membrane interfaces. While a growing number of lipid vesicles, protein, and nucleic acid systems have been explored with nanoplasmonic sensors, there has been only very limited investigation of the interactions between solution-phase nanomaterials and supported lipid membranes. Herein, we established a surface-based localized surface plasmon resonance (LSPR) sensing platform for probing the interaction of dielectric nanoparticles with supported lipid bilayer (SLB)-coated, plasmonic nanodisk arrays...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28638350/branched-chain-amino-acid-ingestion-stimulates-muscle-myofibrillar-protein-synthesis-following-resistance-exercise-in-humans
#14
Sarah R Jackman, Oliver C Witard, Andrew Philp, Gareth A Wallis, Keith Baar, Kevin D Tipton
The ingestion of intact protein or essential amino acids (EAA) stimulates mechanistic target of rapamycin complex-1 (mTORC1) signaling and muscle protein synthesis (MPS) following resistance exercise. The purpose of this study was to investigate the response of myofibrillar-MPS to ingestion of branched-chain amino acids (BCAAs) only (i.e., without concurrent ingestion of other EAA, intact protein, or other macronutrients) following resistance exercise in humans. Ten young (20.1 ± 1.3 years), resistance-trained men completed two trials, ingesting either 5...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28596245/computerised-cognitive-behavioural-therapy-for-adults-with-intellectual-disability-randomised-controlled-trial
#15
Patricia Cooney, Catherine Jackman, David Coyle, Gary O'Reilly
BackgroundDespite the evidence base for computer-assisted cognitive-behavioural therapy (CBT) in the general population, it has not yet been adapted for use with adults who have an intellectual disability.AimsTo evaluate the utility of a CBT computer game for adults who have an intellectual disability.MethodA 2×3 (group×time) randomised controlled trial design was used. Fifty-two adults with mild to moderate intellectual disability and anxiety or depression were randomly allocated to two groups: computerised CBT (cCBT) or psychiatric treatment as usual (TAU), and assessed at pre-treatment, post-treatment and 3-month follow-up...
June 8, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28586650/e6-proteins-of-%C3%AE-and-%C3%AE-cutaneous-hpv-types-differ-in-their-ability-to-potentiate-wnt-signaling
#16
Sophia Sominsky, Naama Shterzer, Anna Jackman, Beny Shapiro, Abraham Yaniv, Levana Sherman
We recently showed that E6 protein of human papillomavirus (HPV) 16, a mucosal high-risk α-PV type, can potentiate Wnt/β-catenin/TCF signaling. Here we investigated the transcriptional activities of E6 proteins of cutaneous HPV types from the β and α genera. Results from reporter-gene assays showed that similar to HPV16 E6, E6 of HPV10, a cutaneous α-HPV type that is prevalent in skin warts, efficiently enhances and stimulates Wnt/β-catenin/TCF transcription. HPV10 E6 also effectively elevated the expression levels of β-catenin and promoted its nuclear accumulation...
September 2017: Virology
https://www.readbyqxmd.com/read/28571316/co-assembly-of-peptide-amphiphiles-and-lipids-into-supramolecular-nanostructures-driven-by-anion-%C3%AF-interactions
#17
Zhilin Yu, Aykut Erbas, Faifan Tantakitti, Liam C Palmer, Joshua A Jackman, Monica Olvera de la Cruz, Nam-Joon Cho, Samuel I Stupp
Co-assembly of binary systems driven by specific non-covalent interactions can greatly expand the structural and functional space of supramolecular nanostructures. We report here on the self-assembly of peptide amphiphiles and fatty acids driven primarily by anion-π interactions. The peptide sequences investigated were functionalized with a perfluorinated phenylalanine residue to promote anion-π interactions with carboxylate headgroups in fatty acids. These interactions were verified here by NMR and circular dichroism experiments as well as investigated using atomistic simulations...
June 1, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28533263/prior-weight-loss-exacerbates-the-biological-drive-to-gain-weight-after-the-loss-of-ovarian-function
#18
Vanessa D Sherk, Matthew R Jackman, Erin D Giles, Janine A Higgins, Rebecca M Foright, David M Presby, Ginger C Johnson, Julie A Houck, Jordan L Houser, Robera Oljira, Paul S MacLean
Both the history of obesity and weight loss may change how menopause affects metabolic health. The purpose was to determine whether obesity and/or weight loss status alters energy balance (EB) and subsequent weight gain after the loss of ovarian function. Female lean and obese Wistar rats were randomized to 15% weight loss (WL) or ad libitum fed controls (CON). After the weight loss period, WL rats were kept in EB at the reduced weight for 8 weeks prior to ovariectomy (OVX). After OVX, all rats were allowed to eat ad libitum until weight plateaued...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28530869/ten-questions-with-%C3%A2
#19
Shawn Jackman
No abstract text is available yet for this article.
May 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28528407/effects-of-feeding-strategy-sediment-characteristics-and-chemical-properties-on-polychlorinated-biphenyl-and-polybrominated-diphenyl-ether-bioaccumulation-from-marine-sediments-in-two-invertebrates
#20
H Frouin, P Jackman, N D Dangerfield, P S Ross
Shellfish and sediment invertebrates have been widely used to assess pollution trends over space and time in coastal environments around the world. However, few studies have compared the bioaccumulation potential of different test species over a range of sediment-contaminant concentrations and profiles. The bioavailability of sediment-related contaminants was evaluated using sediments collected from sites (n = 12) throughout the Salish Sea, British Columbia, Canada. Two benthic marine invertebrates-the Baltic clam Macoma balthica and the polychaete worm Neanthes arenaceodentata-were exposed for 28 days in a controlled environment to these field-collected coastal sediments...
August 2017: Archives of Environmental Contamination and Toxicology
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