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https://www.readbyqxmd.com/read/28193076/integration-of-quartz-crystal-microbalance-dissipation-and-reflection-mode-localized-surface-plasmon-resonance-sensors-for-biomacromolecular-interaction-analysis
#1
Abdul Rahim Ferhan, Joshua A Jackman, Nam-Joon Cho
The combination of label-free, surface-sensitive measurement techniques based on different physical principles enables detailed characterization of biomacromolecular interactions at solid-liquid interfaces. To date, most combined measurement systems have involved experimental techniques with similar probing volumes, whereas the potential of utilizing techniques with different surface sensitivities remains largely unexplored, especially for data interpretation. Herein, we report a combined measurement approach that integrates a conventional quartz crystal microbalance-dissipation (QCM-D) setup with a reflection-mode localized surface plasmon (LSPR) sensor...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28181589/developmental-stage-dependent-effects-of-cardiac-fibroblasts-on-function-of-stem-cell-derived-engineered-cardiac-tissues
#2
Brian Liau, Christopher P Jackman, Yanzhen Li, Nenad Bursac
We investigated whether the developmental stage of mouse cardiac fibroblasts (CFs) influences the formation and function of engineered cardiac tissues made of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs). Engineered cardiac tissue patches were fabricated by encapsulating pure mESC-CMs, mESC-CMs + adult CFs, or mESC-CMs + fetal CFs in fibrin-based hydrogel. Tissue patches containing fetal CFs exhibited higher velocity of action potential propagation and contractile force amplitude compared to patches containing adult CFs, while pure mESC-CM patches did not form functional syncytium...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28142255/-speaking-about-the-unspeakable-clinical-psychologists-views-on-the-role-of-the-profession-regarding-forced-care-of-older-adults-without-capacity
#3
Sarah J Watts, Louisa Jackman, Alan Howarth
'Forced care' describes the provision of personal care to an individual who does not have the capacity to make a decision about that care and resists receiving that care. This study explored the views of clinical psychologists on supporting staff involved with forced care and considered the following question: Do clinical psychologists feel that they have a role in guiding decisions around forced care, and if so, what? Interview data were gathered from five clinical psychologists experienced in the field of Older Adult psychology in the UK...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28121638/epidermolytic-ichthyosis-sine-epidermolysis
#4
Marina Eskin-Schwartz, Marianna Drozhdina, Ofer Sarig, Andrea Gat, Tomer Jackman, Ofer Isakov, Noam Shomron, Liat Samuelov, Natalia Malchin, Alon Peled, Dan Vodo, Alain Hovnanian, Thomas Ruzicka, Sergei Koshkin, Robert M Harmon, Jennifer L Koetsier, Kathleen J Green, Amy S Paller, Eli Sprecher
Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal epidermal keratins. Because of the variable clinical features and severity of the disease, histopathology is often required to correctly direct the molecular analysis. EI is characterized by hyperkeratosis and vacuolar degeneration of the upper epidermis, also known as epidermolytic hyperkeratosis, hence the name of the disease. In the current report, the authors describe members of 2 families presenting with clinical features consistent with EI...
January 17, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28113638/haptic-feedback-manipulation-during-botulinum-toxin-injection-therapy-for-focal-hand-dystonia-patients-a-possible-new-assistive-strategy
#5
Seyed Farokh Atashzar, Mahya Shahbazi, Christopher Ward, Olivia Samotus, Mehdi Delrobaei, Fariborz Rahimi, Jack Lee, Mallory Jackman, Mandar Jog, Rajni Patel
Abnormality of sensorimotor integration in the basal ganglia and cortex has been reported in the literature for patients with task-specific focal hand dystonia (FHD). In this study, we investigate the effect of manipulation of kinesthetic input in people living with writer's cramp disorder (a major form of FHD). For this purpose, severity of dystonia is studied for 11 participants while the symptoms of 7 participants have been tracked during 5 sessions of assessment and Botulinum toxin injection (BoNT-A) therapy (one of the current suggested therapies for dystonia)...
August 19, 2016: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28077086/the-measure-of-success-geographic-isolation-promotes-diversification-in-pachydactylus-geckos
#6
Matthew P Heinicke, Todd R Jackman, Aaron M Bauer
BACKGROUND: Geckos of the genus Pachydactylus and their close relatives comprise the most species-rich clade of lizards in sub-Saharan Africa. Many explanations have been offered to explain species richness patterns of clades. In the Pachydactylus group, one possible explanation is a history of diversification via geographic isolation. If geographic isolation has played a key role in facilitating diversification, then we expect species in more species-rich subclades to have smaller ranges than species in less diverse subclades...
January 11, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28049065/nucleic-acid-scavenging-microfiber-mesh-inhibits-trauma-induced-inflammation-and-thrombosis
#7
Jaewoo Lee, Jennifer G Jackman, Jean Kwun, Miriam Manook, Angelo Moreno, Eric A Elster, Allan D Kirk, Kam W Leong, Bruce A Sullenger
Trauma patients produce a host of danger signals and high levels of damage-associated molecular patterns (DAMPs) after cellular injury and tissue damage. These DAMPs are directly and indirectly involved in the pathogenesis of various inflammatory and thrombotic complications in patients with severe injuries. No effective therapeutic agents for the removal of DAMPs from blood or tissue fluid have been developed. Herein, we demonstrated that nucleic acid binding polymers, e.g., polyethylenimine (PEI) and polyamidoamine dendrimers, immobilized onto electrospun microfiber mesh can effectively capture various DAMPs, such as extracellular DNAs and high mobility group box 1 (HMGB1)...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28045148/investigating-how-vesicle-size-influences-vesicle-adsorption-on-titanium-oxide-a-competition-between-steric-packing-and-shape-deformation
#8
Abdul Rahim Ferhan, Joshua A Jackman, Nam-Joon Cho
Understanding the adsorption behavior of lipid vesicles at solid-liquid interfaces is important for obtaining fundamental insights into soft matter adsorbates as well as for practical applications such as supported lipid bilayer (SLB) fabrication. While the process of SLB formation has been highly scrutinized, less understood are the details of vesicle adsorption without rupture, especially at high surface coverages. Herein, we tackle this problem by employing simultaneous quartz crystal microbalance-dissipation (QCM-D) and localized surface plasmon resonance (LSPR) measurements in order to investigate the effect of vesicle size (84-211 nm diameter) on vesicle adsorption onto a titanium oxide surface...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28042074/a-communications-bundle-to-improve-satisfaction-for-critically-ill-patients-and-their-families-a-prospective-cohort-pilot-study
#9
Rana L Awdish, Dana Buick, Maria Kokas, Hanan Berlin, Catherine Jackman, Cari Williamson, Michael P Mendez, Kristen Chasteen
CONTEXT: Communication skills training with simulated patients is used by many academic centers, but how to translate skills learned in simulated settings to improve communication in real encounters has not been described. OBJECTIVE: We developed a communications bundle to facilitate skill transfer from simulation to real encounters and improve patient and/or family satisfaction with physician communication. We tested the feasibility of its use in our hospital's medical intensive care unit (MICU)...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28032774/the-effects-of-implicit-gender-role-theories-on-gender-system-justification-fixed-beliefs-strengthen-masculinity-to-preserve-the-status-quo
#10
Laura J Kray, Laura Howland, Alexandra G Russell, Lauren M Jackman
Four studies (n = 1199) tested support for the idea that implicit theories about the fixedness versus malleability of gender roles (entity vs. incremental theories) predict differences in the degree of gender system justification, that is, support for the status quo in relations between women and men in society. Relative to an incremental theory, the holding of an entity theory correlated with more system-justifying attitudes and self-perceptions (Study 1) for men and women alike. We also found that strength of identification with one's gender in-group was a stronger predictor of system justification for men than it was for women, suggesting men's defense of the status quo may be motivated by their membership in a high status group in the social hierarchy...
January 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28025642/short-duration-small-sided-football-and-to-a-lesser-extent-whole-body-vibration-exercise-induce-acute-changes-in-markers-of-bone-turnover
#11
RANDOMIZED CONTROLLED TRIAL
J L Bowtell, S R Jackman, S Scott, L J Connolly, M Mohr, G Ermidis, R Julian, F Yousefian, E W Helge, N R Jørgensen, J Fulford, K M Knapp, P Krustrup
We aimed to study whether short-duration vibration exercise or football sessions of two different durations acutely changed plasma markers of bone turnover and muscle strain. Inactive premenopausal women (n = 56) were randomized to complete a single bout of short (FG15) or long duration (FG60) small sided football or low magnitude whole body vibration training (VIB). Procollagen type 1 amino-terminal propeptide (P1NP) was increased during exercise for FG15 (51.6 ± 23.0 to 56.5 ± 22.5 μg·L(-1), mean ± SD, P < 0...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28009294/synaptic-specializations-support-frequency-independent-purkinje-cell-output-from-the-cerebellar-cortex
#12
Josef Turecek, Skyler L Jackman, Wade G Regehr
The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cells (PCs). Here, we characterize the properties of the PC-DCN synapse in juvenile and adult mice and find that prolonged high-frequency stimulation leads to steady-state responses that become increasingly frequency independent within the physiological firing range of PCs in older animals, resulting in a linear relationship between charge transfer and activation frequency. We used a low-affinity antagonist to show that GABAA-receptor saturation occurs at this synapse but does not underlie frequency-invariant transmission...
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/27993715/appearance-of-pyelitis-emphysematosa-on-computed-tomography
#13
Todd S Yecies, Brian T Kadow, Stephen V Jackman
Pyelitis emphysematosa is a gas-forming infection characterized by gas located within the wall of the collecting system and renal pelvis. There are only 2 reported cases of pyelitis emphysematosa in the literature, neither of which occurred in the era of cross-sectional imaging. Here we present a case of pyelitis emphysematosa occurring in an elderly female with congenital left renal atrophy and chronic right hydronephrosis secondary to ureteropelvic junction obstruction.
December 16, 2016: Urology
https://www.readbyqxmd.com/read/27987576/radiologic-pathologic-correlation-of-response-to-chemoradiation-in-resectable-locally-advanced-nsclc
#14
Vishesh Agrawal, Thibaud P Coroller, Ying Hou, Stephanie W Lee, John L Romano, Elizabeth H Baldini, Aileen B Chen, David M Jackman, David Kozono, Scott J Swanson, Jon O Wee, Hugo J W L Aerts, Raymond H Mak
OBJECTIVES: Accurate assessment of tumor response to chemoradiation has the potential to guide clinical decision-making regarding surgical resection and/or dose escalation for patients. Early assessment has implications for Optimal local therapy for operable locally advanced non-small cell lung cancer (LA-NSCLC) is controversial. This study evaluated quantitative CT-based tumor measurements to predict pathologic response. MATERIALS AND METHODS: Patients with operable LA-NSCLC treated with chemoradiation followed by surgical resection were assessed...
December 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27983791/quantitative-profiling-of-nanoscale-liposome-deformation-by-a-localized-surface-plasmon-resonance-sensor
#15
Joshua A Jackman, Saziye Yorulmaz Avsar, Abdul Rahim Ferhan, Danlin Li, Jae Hyeon Park, Vladimir P Zhdanov, Nam-Joon Cho
Characterizing the shape of sub-100 nm, biological soft-matter particulates (e.g., liposomes and exosomes) adsorbed at a solid-liquid interface remains a challenging task. Here, we introduce a localized surface plasmon resonance (LSPR) sensing approach to quantitatively profile the deformation of nanoscale, fluid-phase 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes contacting a titanium dioxide substrate. Experimental and theoretical results validate that, due to its high sensitivity to the spatial proximity of phospholipid molecules near the sensor surface, the LSPR sensor can discriminate fine differences in the extent of ionic strength-modulated liposome deformation at both low and high surface coverages...
December 28, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27981877/performing-under-pressure-exploring-the-psychological-state-underlying-clutch-performance-in-sport
#16
Christian Swann, Lee Crust, Patricia Jackman, Stewart A Vella, Mark S Allen, Richard Keegan
Clutch performance is improved performance under pressure. However, little research has examined the psychological state experienced by athletes in these situations. Therefore, this study qualitatively examined the subjective experience underlying clutch performance across a range of sports (e.g., team, individual) and standards (Olympic to recreational athletes). Sixteen athletes (Mage = 27.08 years; SD = 6.48) took part in in-depth, semi-structured interviews primarily after an exceptional performance (M = 4...
December 16, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27933296/modeling-diet-induced-obesity-with-obesity-prone-rats-implications-for-studies-in-females
#17
REVIEW
Erin D Giles, Matthew R Jackman, Paul S MacLean
Obesity is a worldwide epidemic, and the comorbidities associated with obesity are numerous. Over the last two decades, we and others have employed an outbred rat model to study the development and persistence of obesity, as well as the metabolic complications that accompany excess weight. In this review, we summarize the strengths and limitations of this model and how it has been applied to further our understanding of human physiology in the context of weight loss and weight regain. We also discuss how the approach has been adapted over time for studies in females and female-specific physiological conditions, such as menopause and breast cancer...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27902311/ubiquitin-ligase-e6ap-mediates-nonproteolytic-polyubiquitylation-of-%C3%AE-catenin-independent-of-the-e6-oncoprotein
#18
Yael Kuslansky, Sophia Sominsky, Anna Jackman, Cristina Gamell, Brendon J Monahan, Ygal Haupt, Rina Rosin-Arbesfeld, Levana Sherman
Recently, we showed that the ubiquitin ligase E6AP stabilizes β-catenin and activates its transcriptional activity. These activities were enhanced by the human papillomavirus (HPV) E6 protein. In the present study, we explored the function of E6AP, which increases β-catenin stabilization and transcriptional activation. Here, we report that E6AP interacts with β-catenin and mediates its nonproteolytic ubiquitylation, as evidenced in transiently transfected cell-based and in vitro reconstitution ubiquitylation assays...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27890522/design-and-challenges-of-a-randomized-clinical-trial-of-medical-expulsive-therapy-tamsulosin-for-urolithiasis-in-the-emergency-department
#19
Pamela K Burrows, Judd E Hollander, Allan B Wolfson, Michael C Kurz, Lorna Richards, Sara DiFiore, Phillip Watts, Nivedita Patkar, Jeremy Brown, Stephen Jackman, Ziya Kirkali, John W Kusek, Chloe Michel, Andrew C Meltzer
Urolithiasis or urinary stone disease has been estimated to affect about 1 in 11 Americans. Patients with urinary stone disease commonly present to the emergency department for management of their acute pain. In addition to providing analgesia, administration of drug (medical expulsive therapy) is often prescribed to assist passage of the urinary stone. In this methodology paper, we describe the design of a prospective, multi-center, randomized, double-blind placebo controlled clinical trial of the alpha-adrenergic blocker, tamsulosin, to evaluate its effectiveness as medical expulsive therapy...
January 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27867795/magnetic-reconnection-in-saturn-s-magnetotail-a-comprehensive-magnetic-field-survey
#20
A W Smith, C M Jackman, M F Thomsen
Reconnection within planetary magnetotails is responsible for locally energizing particles and changing the magnetic topology. Its role in terms of global magnetospheric dynamics can involve changing the mass and flux content of the magnetosphere. We have identified reconnection related events in spacecraft magnetometer data recorded during Cassini's exploration of Saturn's magnetotail. The events are identified from deflections in the north-south component of the magnetic field, significant above a background level...
April 2016: Journal of Geophysical Research. Space Physics
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