Jiajia Pan, Yungui Wang, Shujuan Huang, Shihui Mao, Qing Ling, Chenying Li, Fenglin Li, Mengxia Yu, Xin Huang, Jiansong Huang, Yunfei Lv, Xia Li, Wenle Ye, Huafeng Wang, Jinghan Wang, Jie Jin
Previous evidence has confirmed that branched-chain aminotransferase-1 (BCAT1), a key enzyme governing branched-chain amino acid (BCAA) metabolism, has a role in cancer aggression partly by restricting αKG levels and inhibiting the activities of the αKG-dependent enzyme family. The oncogenic role of BCAT1, however, was not fully elucidated in acute myeloid leukemia (AML). In this study, we investigated the clinical significance and biological insight of BCAT1 in AML. Using q-PCR, we analyzed BCAT1 mRNAs in bone marrow samples from 332 patients with newly diagnosed AML...
February 10, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"