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Bipolar NOS

Joseph M Johnson, Chris Y Wu, Gerald Scott Winder, Michael I Casher, Vincent D Marshall, Jolene R Bostwick
Objective This study examines the association between cannabis use and the hospital course of patients admitted to the psychiatric inpatient unit with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. Many confounding variables potentially contribute to the clinical presentation of hospitalized patients in the psychiatric unit. Illicit drug use, in particular, has been associated with acute agitation, and questions can be raised as to what lasting effects drug use prior to admission may have throughout a patient's hospital stay...
October 6, 2016: Journal of Dual Diagnosis
Narendra Kumar, Anil Kumar Mysore Nagaraj, Umashree Koudike, Sumanth Mallikarjuna Majgi
BACKGROUND: A range of psychological disorders occur in women in the postpartum period apart from the traditional blues, postpartum depression and psychosis. These include obsession of infanticide, PTSD, morbid preoccupations regarding child birth and disorders of mother-infant relationships, though they are under emphasized. METHODS: it is a cross-sectional study conducted in the tertiary maternity care hospital. A total of 152 study subjects were interviewed on MINI (Mini International Neuropsychiatric Inventory) and GAF (Global Assessment of Functioning) within 2 weeks after delivery...
July 2016: Indian Journal of Psychological Medicine
James B McCarthy, Shira R Weiss, Kristin T Segovich, Baptiste Barbot
Despite established differences in cognitive functioning of adults with mood disorder-related psychosis and those with non-affective psychotic disorders, there is limited evidence of the impact of psychotic symptoms on the cognitive functioning of children and adolescents with mood disorders. This study investigates IQ, working memory, and processing speed scores in 80 child and adolescent inpatients discharged from an intermediate care state psychiatric hospital, using a retrospective chart review. Associations between diagnosis based on DSM-IV criteria (7 with Major Depression- MDD; 43 with Bipolar Disorders-BD, and 30 with Mood Disorders Not Otherwise Specified-NOS), presence of current psychotic features, and cognitive functioning (WISC-IV IQ, Coding, Symbol Search, and Digit Span) were investigated using Multivariate Analyses of Variance...
October 30, 2016: Psychiatry Research
Basilis Zikopoulos, Yohan J John, Miguel Ángel García-Cabezas, Jamie G Bunce, Helen Barbas
The organization of the inhibitory intercalated cell masses (IM) of the primate amygdala is largely unknown despite their key role in emotional processes. We studied the structural, topographic, neurochemical and intrinsic connectional features of IM neurons in the rhesus monkey brain. We found that the intercalated neurons are not confined to discrete cell clusters, but form a neuronal net that is interposed between the basal nuclei and extends to the dorsally located anterior, central, and medial nuclei of the amygdala...
August 25, 2016: Neuroscience
Saleh Sandoughdaran, Hamed Sadeghipour, Hamid Reza Sadeghipour
BACKGROUND: Lithium has been the treatment of choice for bipolar disorder (BD) for many years. Although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. OBJECTIVE: The aim was to investigate the possible involvement of nitric oxide (NO) in modulatory effect of lithium on penile erection (PE). We further evaluated the possible role of Sildenafil in treatment of lithium-induced erectile dysfunction...
February 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
Isabelle E Bauer, Mon-Ju Wu, T W Frazier, Benson Mwangi, Danielle Spiker, Giovana B Zunta-Soares, Jair C Soares
BACKGROUND: Cognitive deficits have been consistently reported in individuals with bipolar disorder (BD). The cognitive profile of siblings of individuals with BD is, however, less clearly established possibly due to the heterogeneity of neuropsychological measures used in previous studies. The aim of this exploratory study was to assess the cognitive function of siblings of individuals with BD and compare it with that of their first-degree relatives suffering with BD, and healthy controls (HC) using the Cambridge Neuropsychological Test Automated Battery (CANTAB) - a comprehensive and validated computerized cognitive battery...
September 1, 2016: Journal of Affective Disorders
Stefania Schiavone, Luigia Trabace
Redox dysregulation occurs following a disequilibrium between reactive oxygen species (ROS) producing and degrading systems, i.e. mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and nitric oxide synthase (NOS) on one hand and the principal antioxidant system, the glutathione, on the other hand. Increasing recent evidence points towards a pathogenetic role of an altered redox state in the development of several mental disorders, such as anxiety, bipolar disorders, depression, psychosis, autism and post-traumaticstress disorders (PTSD)...
May 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Mary A Fristad, Hannah Wolfson, Guillermo Perez Algorta, Eric A Youngstrom, L Eugene Arnold, Boris Birmaher, Sarah Horwitz, David Axelson, Robert A Kowatch, Robert L Findling
OBJECTIVE: The purpose of this study was to examine similarities and differences between disruptive mood dysregulation disorder (DMDD) and bipolar disorder not otherwise specified (BP-NOS) in baseline sociodemographic and clinical characteristics and 36 month course of irritability in children 6-12.9 years of age. METHODS: A total of 140 children with DMDD and 77 children with BP-NOS from the Longitudinal Assessment of Manic Symptoms cohort were assessed at baseline, then reassessed every 6 months for 36 months...
March 2016: Journal of Child and Adolescent Psychopharmacology
Rachel H B Mitchell, Vanessa Timmins, Jordan Collins, Antonette Scavone, Adam Iskric, Benjamin I Goldstein
OBJECTIVE: The purpose of this study was to examine the prevalence and correlates of disruptive mood dysregulation disorder phenotype (DMDDP) in a clinical population of adolescents with bipolar disorder (BD). METHODS: DMDD criteria were modified and applied to a sample of 116 adolescents with BD-I (n = 30), BD-II (n = 46) or BD-not otherwise specified (NOS) (n = 40) from a tertiary teaching hospital. Diagnoses were determined via the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Aged Children, Present and Lifetime version (KSADS-PL)...
March 2016: Journal of Child and Adolescent Psychopharmacology
Kari Aaltonen, Petri Näätänen, Martti Heikkinen, Maaria Koivisto, Ilya Baryshnikov, Boris Karpov, Jorma Oksanen, Tarja Melartin, Kirsi Suominen, Grigori Joffe, Tiina Paunio, Erkki Isometsä
BACKGROUND: Substantial literature exists on risk factors for suicidal behaviour. However, their comparative strength, independence and specificity for either suicidal ideation or suicide attempt(s) remain unclear. METHODS: The Helsinki University Psychiatric Consortium (HUPC) Study surveyed 287 psychiatric care patients with ICD-10-DCR depressive or bipolar disorders about lifetime suicidal behaviour, developmental history and attachment style, personality and psychological traits, current and lifetime symptom profiles, and life events...
March 15, 2016: Journal of Affective Disorders
Mary A Fristad, Andrea S Young, Anthony T Vesco, Elias S Nader, K Zachary Healy, William Gardner, Hannah L Wolfson, L Eugene Arnold
OBJECTIVE: This pilot study evaluates efficacy of omega-3 fatty acid supplementation (Ω3), individual family psychoeducational psychotherapy (IF-PEP), and their combination in youth with subsyndromal bipolar disorders (bipolar disorder not otherwise specified [BP-NOS], cyclothymic disorder [CYC]). METHODS: This study was a 12 week, randomized trial of Ω3 versus placebo and IF-PEP versus active monitoring (AM) using a 2 × 2 design (Ω3 + PEP: n = 5; Ω3 + AM: n = 5; placebo + PEP: n = 7; placebo + AM: n = 6)...
December 2015: Journal of Child and Adolescent Psychopharmacology
Janet Wozniak, Stephen V Faraone, James Chan, Laura Tarko, Mariely Hernandez, Jacqueline Davis, K Yvonne Woodworth, Joseph Biederman
OBJECTIVE: We conducted a 12-week, randomized, double-blind, controlled clinical trial to evaluate the effectiveness and tolerability of high eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) omega-3 fatty acids and inositol as monotherapy and in combination in children with bipolar spectrum disorders. METHOD: Participants were children 5-12 years of age meeting DSM-IV diagnostic criteria for bipolar spectrum disorders (bipolar I or II disorder or bipolar disorder not otherwise specified [NOS]) and displaying mixed, manic, or hypomanic symptoms...
November 2015: Journal of Clinical Psychiatry
Thiyagu Rajakannan, Daniel J Safer, Mehmet Burcu, Julie Magno Zito
OBJECTIVE: This study examined national trends between 1999 and 2010 in not otherwise specified (NOS) DSM-IV psychiatric diagnoses and in related medication treatment patterns reported for adults during outpatient physician office visits. METHODS: Data on physician office visits by adults (ages 18-64) with a psychiatric diagnosis were from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey (1999-2010) (N=52,026). Trends for visits with full-criteria diagnoses compared with visits with NOS diagnoses were analyzed for major psychiatric diagnostic groups, physician specialty, and prescribed medications...
March 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Filiz Ozdemiroglu, Levent Sevincok, Gulnur Sen, Sanem Mersin, Oktay Kocabas, Kadir Karakus, Fatih Vahapoglu
We examined whether the patients with Bipolar Disorder (BD) and Obsessive-Compulsive Disorder (OCD) comorbidity may represent a distinct form of BD. The subjects diagnosed with BD (n=48), OCD (n=61), and BD with OCD (n=32) were compared in terms of several socio-demographic and clinical characteristics. Previous history of suicidal attempts was more likely to be higher in BD-OCD group compared to the other two groups. A more episodic course of OCD, higher rates of rapid cycling, and the seasonality were found in BD-OCD patients...
December 30, 2015: Psychiatry Research
Daniel P Dickstein, David Axelson, Alexandra B Weissman, Shirley Yen, Jeffrey I Hunt, Benjamin I Goldstein, Tina R Goldstein, Fangzi Liao, Mary Kay Gill, Heather Hower, Thomas W Frazier, Rasim S Diler, Eric A Youngstrom, Mary A Fristad, L Eugene Arnold, Robert L Findling, Sarah M Horwitz, Robert A Kowatch, Neal D Ryan, Michael Strober, Boris Birmaher, Martin B Keller
Greater understanding of cognitive function in children and adolescents with bipolar disorder (BD) is of critical importance to improve our ability to design targeted treatments to help with real-world impairment, including academic performance. We sought to evaluate cognitive performance among children with either BD type I, II, or "not otherwise specified" (NOS) participating in multi-site Course and Outcome of Bipolar Youth study compared to typically developing controls (TDC) without psychopathology. In particular, we sought to test the hypothesis that BD-I and BD-II youths with full threshold episodes of mania or hypomania would have cognitive deficits, including in reversal learning, vs...
June 2016: European Child & Adolescent Psychiatry
Daniel Rapport, Dheeraj Kaplish, Angele McGrady, Ronald McGinnis, Kary Whearty, Manju Thomas, Thomas Fine
BACKGROUND: Bipolar spectrum disorders are associated with symptomatic and functional disability in many patients. Other studies have examined predictors of outcome with variable results. The goal of this retrospective study was to identify medications associated with a minimum of 12 consecutive months of symptomatic, functional, and syndromal remission. METHODS: The charts of 121 patients with confirmed bipolar disorder were reviewed. Data on medical regimen and demographic and adherence factors were gathered using standardized data collection sheets approved by the University of Toledo Institutional Review Board...
September 2015: Journal of Psychiatric Practice
Alan S Karstaedt, Sadhna Kooverjee, Lucille Singh, Yasmien Jeenah, Gregory Jonsson
A retrospective cohort analysis was performed to describe outcomes and retention in care on antiretroviral therapy (ART) of 53 patients with severe mental illness (SMI). Diagnoses were psychosis secondary to HIV (24 patients), psychosis not otherwise specified (12), mania with or without psychosis (9), depression with psychotic features (4), and schizophrenia and bipolar mood disorder (2 each). The median baseline CD4 count was 66/mm(3) and viral load was 5.4 log10 copies/mL. Thirteen (25%) patients were lost to follow-up (10 within 6 months), 3 were transferred out, and 3 died...
September 2015: Journal of the International Association of Providers of AIDS Care
Elif M Sikoglu, Ana A Liso Navarro, Debra Starr, Yael Dvir, Benjamin Udoka Nwosu, Suzanne M Czerniak, Ryan C Rogan, Martha C Castro, Richard A E Edden, Jean A Frazier, Constance M Moore
OBJECTIVE: We aimed to determine the effect of an open-label 8 week Vitamin D3 supplementation on manic symptoms, anterior cingulate cortex (ACC) glutamate, and γ-aminobutyric acid (GABA) in youth exhibiting symptoms of mania; that is, patients with bipolar spectrum disorders (BSD). We hypothesized that an 8 week Vitamin D3 supplementation would improve symptoms of mania, decrease ACC glutamate, and increase ACC GABA in BSD patients. Single time point metabolite levels were also evaluated in typically developing children (TD)...
June 2015: Journal of Child and Adolescent Psychopharmacology
Gianni L Faedda, Ciro Marangoni, Giulia Serra, Paola Salvatore, Gabriele Sani, Gustavo H Vázquez, Leonardo Tondo, Paolo Girardi, Ross J Baldessarini, Athanasios Koukopoulos
OBJECTIVE: To evaluate the presence of affective signs and symptoms as precursors of bipolar disorder in prospective studies, including assessment of their prevalence, duration, and predictive value. DATA SOURCES: We followed PRISMA guidelines to search PubMed, CINAHL, PsycINFO, EMBASE, SCOPUS, and ISI Web of Science databases to May 31, 2013, using the terms bipolar disorder AND (antecedent* OR predict* OR prodrom* OR prospect*) AND (diagnosis OR development). Hand searching of identified reports led to additional relevant references...
May 2015: Journal of Clinical Psychiatry
Chantal Henry, Bruno Etain, Ophelia Godin, Aroldo Ayub Dargel, Jean-Michel Azorin, Sébastien Gard, Frank Bellivier, Thierry Bougerol, Jean-Pierre Kahn, Christine Passerieux, Valerie Aubin, Philippe Courtet, Marion Leboyer
OBJECTIVE: A national network of expert centers for bipolar disorders was set up in France to provide support, mainly for psychiatrists, who need help for managing bipolar disorder patients. The aims of this article are to present the main characteristics of the patients referred to an expert center in order to highlight the major disturbances affecting these patients and to understand the most significant difficulties encountered by practitioners dealing with bipolar disorder patients...
October 2015: Australian and New Zealand Journal of Psychiatry
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