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https://www.readbyqxmd.com/read/28762173/methylene-blue-and-its-analogues-as-antidepressant-compounds
#1
REVIEW
Anzelle Delport, Brian H Harvey, Anél Petzer, Jacobus P Petzer
Methylene Blue (MB) is considered to have diverse medical applications and is a well-described treatment for methemoglobinemias and ifosfamide-induced encephalopathy. In recent years the focus has shifted to MB as an antimalarial agent and as a potential treatment for neurodegenerative disorders such as Alzheimer's disease. Of interest are reports that MB possesses antidepressant and anxiolytic activity in pre-clinical models and has shown promise in clinical trials for schizophrenia and bipolar disorder. MB is a noteworthy inhibitor of monoamine oxidase A (MAO-A), which is a well-established target for antidepressant action...
July 31, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28759262/a-double-blind-and-placebo-controlled-trial-of-aripiprazole-in-symptomatic-youths-at-genetic-high-risk-for-bipolar-disorder
#2
Robert L Findling, Eric A Youngstrom, Brieana M Rowles, Elizabeth Deyling, Jacqui Lingler, Robert J Stansbrey, Molly McVoy, Sarah Lytle, Joseph R Calabrese, Nora K McNamara
OBJECTIVE: To determine if acute treatment with aripiprazole (APZ) would be superior to treatment with placebo in reducing dysfunctional symptoms of elevated mood and/or irritability in symptomatic children and adolescents at familial high risk for bipolar disorder (BPD) whose mood episodes occur spontaneously. These are patients we have previously referred to as suffering from "cyclotaxia." METHODS: This was single-site, randomized, double-blind, placebo-controlled outpatient clinical trial in which youths aged 5-17 years who met diagnostic criteria for either cyclothymic disorder (CYC) or BPD not otherwise specified (BP-NOS) were randomly assigned to receive either APZ or placebo...
July 31, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28720408/comparative-investigation-of-neuronal-nitric-oxide-synthase-immunoreactivity-in-rat-and-human-claustrum
#3
Boycho Landzhov, Dimka Hinova-Palova, Lawrence Edelstein, Elena Dzhambazova, Ilina Brainova, Georgi P Georgiev, Vesela Ivanova, Adrian Paloff, Wladimir Ovtscharoff
We compared the distribution, density and morphological characteristics of nitric oxide synthase-immunoreactive (NOS-ir) neurons in the rat and human claustrum. These neurons were categorized by diameter into three main types: large, medium and small. In the human claustrum, large neurons ranged from 26 to 40μm in diameter, medium neurons from 20 to 25μm and small neurons from 13 to 19μm. In the rat claustrum, large neurons ranged from 19 to 23μm in diameter, medium neurons from 15 to 18μm and small neurons from 10 to 14μm...
July 15, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28579034/no-signaling-in-retinal-bipolar-cells
#4
A Agurto, A H Vielma, B Cadiz, E Couve, O Schmachtenberg
Nitric oxide (NO) is a neuromodulator involved in physiological and pathological processes in the retina. In the inner retina, a subgroup of amacrine cells have been shown to synthesize NO, but bipolar cells remain controversial as NO sources. This study correlates NO synthesis in dark-adapted retinas, through labeling with the NO marker DAF-FM, with neuronal nitric oxide synthase (nNOS) and inducible NOS expression, and presence of the NO receptor soluble guanylate cyclase in bipolar cells. NO containing bipolar cells were morphologically identified by dialysis of DAF fluorescent cells with intracellular dyes, or by DAF labeling followed by immunohistochemistry for nNOS and other cellular markers...
August 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28552295/transcranial-direct-current-stimulation-tdcs-for-bipolar-depression-a-systematic-review-and-meta-analysis
#5
REVIEW
Clément Dondé, Ali Amad, Isabel Nieto, André Russowsky Brunoni, Nicholas H Neufeld, Frank Bellivier, Emmanuel Poulet, Pierre-Alexis Geoffroy
OBJECTIVE: Bipolar disorder (BD) is a severe and recurrent brain disorder that can manifest in manic or depressive episodes. Transcranial Direct Current Stimulation (tDCS) has been proposed as a novel therapeutic modality for patients experiencing bipolar depression, for which standard treatments are often inefficient. While several studies have been conducted in this patient group, there has been no systematic review or meta-analysis that specifically examines bipolar depression. We aimed to address this gap in the literature and evaluated the efficacy and tolerability of tDCS in patients fulfilling DSM-IV-TR criteria for BD I, II, or BD not otherwise specified (NOS)...
August 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28484349/one-year-follow-up-of-patients-with-a-diagnosis-of-first-episode-psychosis
#6
Atena Enderami, Fatemeh Sheikh Monesi, Mehran Zarghami
INTRODUCTION: Early diagnosis of symptoms related to psychotic disorders causes hyper responsiveness, recurrence reduction and quality of life improvement. The aim of this study was one-year follow-up of the clinical course and outcomes of hospitalized patients with first episode psychotic disorders and detection of factors affecting consequences. METHODS: This longitudinal descriptive study was conducted during 2012 to 2013 on hospitalized patients at Zare Hospital in Sari, Iran, with any psychotic symptoms and with diagnosis of first episode psychosis...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28480486/clinical-correlates-of-age-at-onset-distribution-in-bipolar-disorder-a-comparison-between-diagnostic-subgroups
#7
Mirko Manchia, Giuseppe Maina, Bernardo Carpiniello, Federica Pinna, Luca Steardo, Virginia D'Ambrosio, Virginio Salvi, Martin Alda, Alfonso Tortorella, Umberto Albert
BACKGROUND: Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO as well as the clinical features of EO BD type 1 (BD1) with EO BD type 2 (BD2). To this end, we studied 515 BD patients (224 BD1, 279 BD2, and 12 BD not otherwise specified [NOS]) diagnosed according to DSM-IV-TR criteria. METHODS: AAO was defined as the first reliably diagnosed hypo/manic or depressive episode according to diagnostic criteria...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28365522/longitudinal-course-and-characteristics-of-cyclothymic-disorder-in-youth
#8
Anna R Van Meter, Eric A Youngstrom, Boris Birmaher, Mary A Fristad, Sarah M Horwitz, Thomas W Frazier, L Eugene Arnold, Robert L Findling
OBJECTIVES: Epidemiological studies suggest that cyclothymic disorder is the most prevalent subtype of bipolar disorder (BD). However, it is rarely diagnosed, especially in youth. This may be because it can be difficult to ascertain whether a youth meets diagnostic criteria. Clearer, easy-to-apply criteria could reduce misdiagnosis. The objective oftable this study was to determine whether proposed research diagnostic criteria for cyclothymic disorder (RDCyc), based on DSM-5 criteria, could be quantified and validated in youth...
June 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28360522/long-term-efficacy-and-safety-of-lamotrigine-for-all-types-of-bipolar-disorder
#9
Yoshinori Watanabe, Seiji Hongo
BACKGROUND: We investigated whether the long-term efficacy and safety of lamotrigine (LTG) for bipolar disorder (BP) differs between disease types (BP-I, BP-II, or BP not otherwise specified [BP-NOS]), and the efficacy of the concomitant use of antidepressants (ADs). METHODS: For >1 year, we observed 445 outpatients with BP (diagnosed by DSM-IV criteria) who initiated LTG treatment between July 1 and October 31, 2011, using the Himorogi Self-rating Depression (HSDS) and Anxiety Scales and the Clinical Global Impression-Improvement scale and also recorded adverse events...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27977470/the-utility-of-low-dose-aripiprazole-for-the-treatment-of-bipolar-ii-and-bipolar-nos-depression
#10
Tammas Kelly, Daniel Z Lieberman
BACKGROUND: Despite initial reports of efficacy in bipolar depression, multicenter trials did not show aripiprazole to be better than placebo, possibly because the doses used were too high, leading to lower efficacy and high dropout rates. This study evaluated the effects of low-dose aripiprazole. Extensive clinical experience has suggested that doses beyond 5 mg are rarely efficacious. METHODS: Data were gathered from patients with bipolar II or bipolar not otherwise specified depression using a retrospective chart review...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27871641/longitudinal-course-of-bipolar-disorder-in-youth-with-high-functioning-autism-spectrum-disorder
#11
Xenia Borue, Carla Mazefsky, Brian T Rooks, Michael Strober, Martin B Keller, Heather Hower, Shirley Yen, Mary Kay Gill, Rasim S Diler, David A Axelson, Benjamin I Goldstein, Tina R Goldstein, Neal Ryan, Fangzi Liao, Jeffrey I Hunt, Daniel P Dickstein, Boris Birmaher
OBJECTIVE: To provide the first longitudinal characterization of mood and psychosocial functioning in youth with comorbid bipolar (BD) and autism spectrum (ASD) disorders. METHOD: The Course and Outcome of Bipolar Youth study followed 368 youth (aged 7-17 years) with DSM-IV bipolar I (BP-I), BP-II, or Not Otherwise Specified (NOS) for, on average, 9 years using the Longitudinal Interval Follow-up Evaluation. This subgroup analysis compared youth with and without ASD on clinical presentation, percentage of time with mood symptomatology, and psychosocial functioning...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27822276/demographic-and-diagnostic-features-of-3147-inpatients-with-mood-disorders-in-iran
#12
Atefeh Ghanbari Jolfaei, Pari Ghadamgahi, Masoud Ahmadzad-Asl, Amir Shabani
OBJECTIVES: To assess and compare demographic and diagnostic characteristics of inpatients with mood disorders in Iran. MATERIALS AND METHODS: We collected the demographic, clinical, and treatment characteristics of patients, who were hospitalized during five years from April 2006 to March 2010, in Iran hospital of psychiatry, a residency training center to evaluate the general clinical picture of the disorder. RESULTS: Overall, 95.3% of subjects had a diagnosis of bipolar I disorder (BID), 2...
September 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27710762/the-effects-of-cannabis-on-inpatient-agitation-aggression-and-length-of-stay
#13
Joseph M Johnson, Chris Y Wu, Gerald Scott Winder, Michael I Casher, Vincent D Marshall, Jolene R Bostwick
OBJECTIVE: This study examines the association between cannabis use and the hospital course of patients admitted to the psychiatric inpatient unit with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. Many confounding variables potentially contribute to the clinical presentation of hospitalized patients in the psychiatric unit. Illicit drug use, in particular, has been associated with acute agitation, and questions can be raised as to what lasting effects drug use prior to admission may have throughout a patient's hospital stay...
July 2016: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/27570341/psychiatric-morbidity-and-correlates-in-postpartum-women-in-a-tertiary-care-hospital
#14
Narendra Kumar, Anil Kumar Mysore Nagaraj, Umashree Koudike, Sumanth Mallikarjuna Majgi
BACKGROUND: A range of psychological disorders occur in women in the postpartum period apart from the traditional blues, postpartum depression and psychosis. These include obsession of infanticide, PTSD, morbid preoccupations regarding child birth and disorders of mother-infant relationships, though they are under emphasized. METHODS: it is a cross-sectional study conducted in the tertiary maternity care hospital. A total of 152 study subjects were interviewed on MINI (Mini International Neuropsychiatric Inventory) and GAF (Global Assessment of Functioning) within 2 weeks after delivery...
July 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27497293/impact-of-psychotic-symptoms-on-cognitive-functioning-in-child-and-adolescent-psychiatric-inpatients-with-severe-mood-disorders
#15
James B McCarthy, Shira R Weiss, Kristin T Segovich, Baptiste Barbot
Despite established differences in cognitive functioning of adults with mood disorder-related psychosis and those with non-affective psychotic disorders, there is limited evidence of the impact of psychotic symptoms on the cognitive functioning of children and adolescents with mood disorders. This study investigates IQ, working memory, and processing speed scores in 80 child and adolescent inpatients discharged from an intermediate care state psychiatric hospital, using a retrospective chart review. Associations between diagnosis based on DSM-IV criteria (7 with Major Depression- MDD; 43 with Bipolar Disorders-BD, and 30 with Mood Disorders Not Otherwise Specified-NOS), presence of current psychotic features, and cognitive functioning (WISC-IV IQ, Coding, Symbol Search, and Digit Span) were investigated using Multivariate Analyses of Variance...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27256508/the-intercalated-nuclear-complex-of-the-primate-amygdala
#16
Basilis Zikopoulos, Yohan J John, Miguel Ángel García-Cabezas, Jamie G Bunce, Helen Barbas
The organization of the inhibitory intercalated cell masses (IM) of the primate amygdala is largely unknown despite their key role in emotional processes. We studied the structural, topographic, neurochemical and intrinsic connectional features of IM neurons in the rhesus monkey brain. We found that the intercalated neurons are not confined to discrete cell clusters, but form a neuronal net that is interposed between the basal nuclei and extends to the dorsally located anterior, central, and medial nuclei of the amygdala...
August 25, 2016: Neuroscience
https://www.readbyqxmd.com/read/27200425/effect-of-acute-lithium-administration-on-penile-erection-involvement-of-nitric-oxide-system
#17
Saleh Sandoughdaran, Hamed Sadeghipour, Hamid Reza Sadeghipour
BACKGROUND: Lithium has been the treatment of choice for bipolar disorder (BD) for many years. Although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. OBJECTIVE: The aim was to investigate the possible involvement of nitric oxide (NO) in modulatory effect of lithium on penile erection (PE). We further evaluated the possible role of Sildenafil in treatment of lithium-induced erectile dysfunction...
February 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27179338/neurocognitive-functioning-in-individuals-with-bipolar-disorder-and-their-healthy-siblings-a-preliminary-study
#18
Isabelle E Bauer, Mon-Ju Wu, T W Frazier, Benson Mwangi, Danielle Spiker, Giovana B Zunta-Soares, Jair C Soares
BACKGROUND: Cognitive deficits have been consistently reported in individuals with bipolar disorder (BD). The cognitive profile of siblings of individuals with BD is, however, less clearly established possibly due to the heterogeneity of neuropsychological measures used in previous studies. The aim of this exploratory study was to assess the cognitive function of siblings of individuals with BD and compare it with that of their first-degree relatives suffering with BD, and healthy controls (HC) using the Cambridge Neuropsychological Test Automated Battery (CANTAB) - a comprehensive and validated computerized cognitive battery...
September 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26995306/pharmacological-targeting-of-redox-regulation-systems-as-new-therapeutic-approach-for-psychiatric-disorders-a-literature-overview
#19
REVIEW
Stefania Schiavone, Luigia Trabace
Redox dysregulation occurs following a disequilibrium between reactive oxygen species (ROS) producing and degrading systems, i.e. mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and nitric oxide synthase (NOS) on one hand and the principal antioxidant system, the glutathione, on the other hand. Increasing recent evidence points towards a pathogenetic role of an altered redox state in the development of several mental disorders, such as anxiety, bipolar disorders, depression, psychosis, autism and post-traumaticstress disorders (PTSD)...
May 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26859630/disruptive-mood-dysregulation-disorder-and-bipolar-disorder-not-otherwise-specified-fraternal-or-identical-twins
#20
Mary A Fristad, Hannah Wolfson, Guillermo Perez Algorta, Eric A Youngstrom, L Eugene Arnold, Boris Birmaher, Sarah Horwitz, David Axelson, Robert A Kowatch, Robert L Findling
OBJECTIVE: The purpose of this study was to examine similarities and differences between disruptive mood dysregulation disorder (DMDD) and bipolar disorder not otherwise specified (BP-NOS) in baseline sociodemographic and clinical characteristics and 36 month course of irritability in children 6-12.9 years of age. METHODS: A total of 140 children with DMDD and 77 children with BP-NOS from the Longitudinal Assessment of Manic Symptoms cohort were assessed at baseline, then reassessed every 6 months for 36 months...
March 2016: Journal of Child and Adolescent Psychopharmacology
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