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https://www.readbyqxmd.com/read/29881656/somatosensory-evoked-potentials-as-a-tool-to-evaluate-brainstem-herniation-in-the-neuroscience-intensive-care-unit
#1
Nakul Katyal, Christopher R Newey, Pravin George, Premkumar Nattanamai, Jonathan M Beary, Agnieszka Ardelt, Anantha Vellipuram
Somatosensory evoked potentials (SSEPs) are a sensitive, minimally invasive technique used to localize dysfunction of myelinated peripheral and central axons in the nervous system. The utility of SSEPs in acutely assessing central nervous system function in brainstem herniation in the neuroscience intensive care unit (NICU) has not been well established. We discuss a case of an 18-year-old, postpartum female who presented with intermittent headache, diplopia, nausea/vomiting and cachexia following delivery two months prior...
April 6, 2018: Curēus
https://www.readbyqxmd.com/read/29877111/peitc-promotes-neurite-growth-in-primary-sensory-neurons-via-the-mir-17-5p-stat3-gap-43-axis
#2
Zhijie Wang, Wenqi Yuan, Bo Li, Xueming Chen, Yanjun Zhang, Chuanjie Chen, Mei Yu, Yucai Xiu, Wenhua Li, Jiangang Cao, Xin Wang, Wen Tao, Xiaoling Guo, Shiqing Feng, Tianyi Wang
The present study explored a key miRNA that plays a vital role in sciatic nerve conditioning injury promoting repair of injured dorsal column, and validated its function. Microarray analysis revealed miR-17-5p expression decreased sharply at 3, 7 and 14 days in the sciatic nerve conditioning injury group compared with the simple dorsal column lesion group. After miR-17-5p inhibition in DRG neurons, GAP-43 expression was upregulated and neurite growth was increased. STAT3 together with p-STAT3 showed opposite trends with miR-17-5p...
June 7, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29790404/clinical-and-neurophysiological-changes-after-targeted-intrathecal-injections-of-bone-marrow-stem-cells-in-a-c3-tetraplegic-subject
#3
Andrea Jimena Santamaria, Francisco D Benavides, Darcy L DiFede, Aisha Khan, Marietsy V Pujol, W Dalton Dietrich, Antonio Marttos, Barth A Green, Joshua M Hare, James Guest
High-level quadriplegia is a devastating condition with limited treatment options. Bone marrow derived stem cells (BMSCs) are reported to have immunomodulatory and neurotrophic effects in spinal cord injury (SCI). We report a subject with complete C2 SCI who received 3 anatomically targeted intrathecal infusions of BMSCs under a single-patient expanded access IND. She underwent intensive physical therapy and was followed for over 2 years. At end-point, her AIS grade improved from A to B and she recovered focal pressure touch sensation over several body areas...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29787402/a-pilot-study-of-a-novel-automated-somatosensory-evoked-potential-ssep-monitoring-device-for-detection-and-prevention-of-intraoperative-peripheral-nerve-injury-in-total-shoulder-arthroplasty-surgery
#4
Jason Chui, John M Murkin, Darren Drosdowech
INTRODUCTION: Peripheral nerve injury is a potentially devastating complication after total shoulder arthroplasty (TSA) surgery. This pilot study aimed to assess the feasibility of using an automated somatosensory evoked potential (SSEP) device to provide a timely alert/intervention to minimize intraoperative nerve insults during TSA surgery. METHODS: A prospective, single-arm, observational study was conducted in a single university hospital. The attending anesthesiologist monitored the study participants using the EPAD automated SSEP device and an intervention was made if there was an alert during TSA surgery...
May 21, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29772366/giant-cell-ependymoma-of-cervical-medullary-junction-a-case-report-of-a-long-term-survivor-and-review-of-literature
#5
REVIEW
Martina Cappelletti, Andrea G Ruggeri, Giorgia Iacopino, Roberto Delfini
Ependymoma accounts for 3-9% of all neuroepithelial tumors. The giant cell ependymoma is a rare and distinct variant, of which only twenty-two cases have been described in literature. Starting from 2007, the WHO acknowledged this rare subtype. The cytological features of GCE are the presence of pleomorphic giant cells with several cellular atypias, which at intra-operative frozen diagnosis may appear to be high-grade glial lesions. Despite its apparently malignant histology, GCE seems to be a neoplasm with a relatively good prognosis...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29710747/effect-of-rehabilitation-on-the-somatosensory-evoked-potentials-and-gait-performance-of-hemiparetic-stroke-patients
#6
Hyun S Yoon, Young J Cha, Min K Sohn, Joshua Sung H You
BACKGROUND: Gait performance of stroke patients is affected by impaired sensory ability. The purpose of the present study was to determine the relationship between somatosensory-evoked potential (SSEP) parameters and gait performance in hemiparetic stroke patients. METHODS: A convenience sample of 17 hemiparetic stroke patients (mean age 60.11 ± 8.83 years; 10 women; right hemiplegia: 10, left hemiplegia: 7) were recruited for the present study. The Electro Synergy system (Viasys Healthcare; San Diego, CA, USA) was used for SSEP evaluation...
April 18, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29707900/an-observational-case-series-of-spinal-cord-stimulation-waveforms-visualized-on-intraoperative-neuromonitoring
#7
Steven M Falowski
INTRODUCTION: Intraoperative neuromonitoring for spinal cord stimulation uses electromyography (EMG) responses to determine myotomal coverage as a marker for dermatomal coverage. These responses are utilized to determine the orientation of the electrode. Somatosensory evoked potential (SSEP) collision testing can also be used in which sensory signals are decreased and/or eliminated when stimulation is activated. METHODS: Fifteen patients were observed in the study...
April 29, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29669030/the-efficacy-of-intraoperative-neurophysiological-monitoring-to-detect-postoperative-neurological-deficits-in-transforaminal-lumbar-interbody-fusion-surgery
#8
Joung Heon Kim, Svetlana Lenina, Grace Mosley, Joshua Meaike, Benjamin Tran, Jun S Kim, Samuel K Cho
BACKGROUND: Despite the extensive use of intraoperative neurophysiological monitoring (IONM) in spinal procedures, there is no standard guideline for what types of IONM tests should be monitored during lumbar procedures with instrumentation. Moreover, the efficacy of IONM during transforaminal lumbar interbody fusion (TLIF) surgery in detecting postoperative neurological deficits has not been well described. OBJECTIVE: To analyze waveform changes from individual IONM tests (somatosensory evoked potentials [SSEP], motor evoked potentials [MEP], and electromyography [EMG]) during TLIF and compare the sensitivity and specificity of these tests in order to determine the best combination to detect postoperative neurological deficits...
April 13, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29505853/use-of-motor-evoked-potentials-during-lateral-lumbar-interbody-fusion-reduces-postoperative-deficits
#9
Michael R Riley, Adam T Doan, Richard W Vogel, Alexander O Aguirre, Kayla S Pieri, Edward H Scheid
BACKGROUND CONTEXT: Intraoperative neurophysiological monitoring (IONM) has gained rather widespread acceptance as a method to mitigate risk to the lumbar plexus during lateral lumbar interbody fusion (LLIF) surgery. The most common approach to IONM involves using only electromyography (EMG) monitoring, and the rate of postoperative deficit remains unacceptably high. Other test modalities, such as transcranial electric motor-evoked potentials (tcMEPs) and somatosensory-evoked potentials, may be more suitable for monitoring neural integrity, but they have not been widely adopted during LLIF...
April 3, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29501883/positive-pharmacologic-provocative-testing-with-methohexital-during-cerebral-arteriovenous-malformation-embolization
#10
Orhan Bican, Charles Cho, Leslie Lee, Viet Nguyen, Scheherazade Le, Jeremy Heit, Jaime Lopez
A middle-aged patient underwent staged endovascular embolization of a Spetzler-Martin grade V right parietal arteriovenous malformation(AVM).In the fifth endovascular embolization, after methohexital 10 mg injection into a right posterior choroidal artery feeding the AVM nidus, there was an immediate change in the electroencephalogram (EEG) with simultaneous loss of motor evoked potentials (MEPs) in the bilateral upper and lower extremities and a delayed change in somatosensory evoked potential responses (SSEPs)...
February 25, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29465895/-clinical-neurophysiological-methods-in-diagnosis-and-treatment-of-cerebrovascular-diseases
#11
REVIEW
Ildikó Nagy, Dániel Fabó
Neurophysiological methods are gaining ground in the diagnosis and therapy of cerebrovascular disease. While the role of the EEG (electroencephalography) in the diagnosis of post-stroke epilepsy is constant, quantitative EEG para-meters, as new indicators of early efficiency after thrombolysis or in prognosis of patient's condition have proved their effectiveness in several clinical studies. In intensive care units, continuous EEG monitoring of critically ill patients became part of neurointenzive care protocols...
January 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29388926/-the-role-of-the-neurophysiological-methods-in-the-assessment-of-the-effectiveness-of-the-rehabilitation-of-sensorimotor-disturbances-associated-with-the-lesions-of-the-central-nervous-system-at-the-spinal-cord-level
#12
E V Ekusheva, V B Voitenkov, N V Skripchenko, I G Samoilova, V A Filimonov
AIM: The objective of the present study was the evaluation and comparison of the effectiveness of the differential approaches to the neurorehabilitation of the somatosensory disturbances in the patients presenting with the spinal cord lesions. MATERIALS AND METHODS: A total of 68 patients with spinal cord lesions were enrolled in the study, including 38 suffering from vascular myelopathy, 18 with the consequences of extramedullar meningioma surgery, 12 with the sequelae of acute transverse myelitis...
December 28, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29385211/noninvasive-measurement-of-dynamic-brain-signals-using-light-penetrating-the-brain
#13
Osamu Hiwaki, Hideki Miyaguchi
Conventional techniques for the noninvasive measurement of brain activity involve critical limitations in spatial or temporal resolution. Here, we propose the method for noninvasive brain function measurement with high spatiotemporal resolution using optical signals. We verified that diffused near-infrared light penetrating through the upper jaw and into the skull, which we term as optoencephalography (OEG), leads to the detection of dynamic brain signals that vary concurrently with the electrophysiological neural activity...
2018: PloS One
https://www.readbyqxmd.com/read/29313181/intraoperative-neurophysiological-monitoring-during-spinal-surgery-technical-review-in-open-and-minimally-invasive-approaches
#14
REVIEW
Fabio Cofano, Francesco Zenga, Marco Mammi, Roberto Altieri, Nicola Marengo, Marco Ajello, Paolo Pacca, Antonio Melcarne, Carola Junemann, Alessandro Ducati, Diego Garbossa
Neurophysiological monitoring is of undoubted value for the intraoperative safety of neurosurgical procedures. Widely developed and used for cranial surgery, it is equally as effective, though perhaps less commonly employed, for spinal pathology. The most frequently used techniques for intraoperative monitoring during spinal surgery include somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs) and electromyography, which can either be spontaneous free-running (sEMG) or triggered (tEMG). The knowledge of the benefits and limitations of each modality is essential in optimising the value of intraoperative monitoring during spinal procedures...
January 8, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29248202/clonidine-administration-during-intraoperative-monitoring-for-pediatric-scoliosis-surgery-effects-on-central-and-peripheral-motor-responses
#15
Pedro Calderón, Paul Deltenre, Ida Stany, Jean-Paul Kaleeta Maalu, Magali Stevens, Jean Lamoureux, Michel Bellemans, Sylvie Dujardin, Philippe Van der Linden, Bernard Dachy
OBJECTIVE: To study the effect of clonidine administrated as a co-analgesic during scoliosis surgery, on the neuromonitoring of spinal motor pathways. METHODS: Using standardized intraoperative monitoring, we compared the time course of peripherally and transcranially electrically evoked motor potentials (TcEMEPs) before and after injection of a single bolus of clonidine in children under total intravenous anesthesia (TIVA). MEP data were obtained from 9 patients and somatosensory evoked potentials (SSEPs) were obtained from 2 patients...
April 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29241172/neurophysiological-monitoring-and-awake-craniotomy-for-resection-of-intracranial-gliomas
#16
Taiichi Saito, Manabu Tamura, Mikhail F Chernov, Soko Ikuta, Yoshihiro Muragaki, Takashi Maruyama
Aggressive resection of intracranial gliomas has a positive impact on patients' prognosis, but is associated with a risk of neurological complications. For preservation of brain functions and avoidance of major postoperative morbidity various methods of intraoperative neurophysiological monitoring have been introduced into clinical practice. At present, somatosensory evoked potentials (SSEP), motor evoked potentials (MEP), visual evoked potentials (VEP), brainstem auditory evoked potentials (BAEP), and electrocorticography (ECoG) are used routinely during neurosurgical procedures...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29189973/somatosensory-evoked-potentials-after-decompressive-craniectomy-for-traumatic-brain-injury
#17
Allison Bethune, Nadia Scantlebury, Ekaterina Potapova, Nicole Dinn, Victor Yang, Todd Mainprize, Mahmood Fazl, Farhad Pirouzmand, Leodante da Costa, Martin Chapman, Nicolas Phan
Somatosensory evoked potentials (SSEPs) are used for neuroprognosis after severe traumatic brain injury (TBI). However decompressive craniectomy (DC), involving removal of a portion of the skull to alleviate elevated intracranial pressure, is associated with an increase in SSEP amplitude. Accordingly, SSEPs are not available for neuroprognosis over the hemisphere with DC. We aim to determine the degree to which SSEP amplitudes are increased in the absence of cranial bone. This will serve as a precursor for translation to clinically prognostic ranges...
November 30, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29164724/intraoperative-localization-of-the-subthalamic-nucleus-using-long-latency-somatosensory-evoked-potentials
#18
Carlos Trenado, Saskia Elben, Lena Friggemann, Stefan Jun Groiss, Jan Vesper, Alfons Schnitzler, Lars Wojtecki
BACKGROUND: Target localization for deep brain stimulation (DBS) is a challenging step that determines not only the correct placement of stimulation electrodes, but also influences the success of the DBS procedure as reflected in the desired clinical outcome of a patient. OBJECTIVE: We report on the feasibility of DBS target localization in the subthalamic nucleus (STN) by long-latency somatosensory evoked potentials (LL-SSEPs) (>40 msec) in Parkinson's disease (PD) patients...
November 22, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29147795/preoperative-pregabalin-has-no-effect-on-intraoperative-neurophysiological-monitoring-in-adolescents-undergoing-posterior-spinal-fusion-for-spinal-deformities-a-double-blind-randomized-placebo-controlled-clinical-trial
#19
Linda Helenius, Antti Puhakka, Tuula Manner, Olli Pajulo, Ilkka Helenius
PURPOSE: This study was designed to evaluate the effect of preoperative pregabalin on intraoperative neurophysiological monitoring in adolescents undergoing surgery for spinal deformities. METHODS: Thirty-one adolescents undergoing posterior spinal fusion were randomized to receive preoperatively either pregabalin 2 mg/kg twice daily or placebo. The ability to make reliable intraoperative neurophysiological measurements, transcranial motor (MEPs) and sensory evoked potentials (SSEP) was evaluated...
February 2018: European Spine Journal
https://www.readbyqxmd.com/read/29074466/neuroprotective-assessment-of-prolonged-local-hypothermia-post-contusive-spinal-cord-injury-in-rodent-model
#20
Daniel Boon Loong Teh, Soo Min Chua, Ankshita Prasad, Ioannis Kakkos, Wenxuan Jiang, Mu Yue, Xiaogang Liu, Angelo Homayoun All
BACKGROUND CONTEXT: Although general hypothermia is recognized as a clinically applicable neuroprotective intervention, acute moderate local hypothermia post contusive spinal cord injury (SCI) is being considered a more effective approach. Previously, we have investigated the feasibility and safety of inducing prolonged local hypothermia in the central nervous system of a rodent model. PURPOSE: Here, we aimed to verify the efficacy and neuroprotective effects of 5 and 8 hours of local moderate hypothermia (30±0...
March 2018: Spine Journal: Official Journal of the North American Spine Society
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