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Stroke innovation

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https://www.readbyqxmd.com/read/29660947/effects-of-walkbot-gait-training-on-kinematics-kinetics-and-clinical-gait-function-in-paraplegia-and-quadriplegia
#1
Jongseok Hwang, Yongil Shin, Ji-Ho Park, Young Joo Cha, Joshua Sung H You
BACKGROUND: The robotic-assisted gait training (RAGT) system has gained recognition as an innovative, effective paradigm to improve functional ambulation and activities of daily living in spinal cord injury and stroke. However, the effects of the Walkbot robotic-assisted gait training system with a specialized hip-knee-ankle actuator have never been examined in the paraplegia and quadriplegia population. OBJECTIVE: The aim of this study was to determine the long-term effects of Walkbot training on clinical for hips and knee stiffness in individuals with paraplegia or quadriplegia...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29618309/genetics-and-gene-therapy-of-anderson-fabry-disease
#2
Irene Simonetta, Antonino Tuttolomondo, Tiziana Di Chiara, Salvatore Miceli
Fabry's disease is a genetic disorder of X-linked inheritance caused by mutations in the alpha galactosidase A gene resulting in deficiency of this lysosomal enzyme. The progressive accumulation of glycosphingolipids, caused by the inadequate enzymatic activity, is responsible of organ dysfunction and thus of clinical manifestations. In presence of a high clinical suspicion, a careful physical examination and specific laboratory tests are required, finally diagnosis of Fabry's disease is confirmed by demonstration of absence or reduced alpha galactosidase A enzyme activity in hemizygous men and gene typing in heterozygous females; in fact the performance of enzymatic activity assay alone in women is inconclusive...
April 4, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29609504/modified-approach-to-stroke-rehabilitation-mastr-feasibility-study-of-a-method-to-apply-procedural-memory-concepts-to-transfer-training
#3
Marykay A Pavol, Clare C Bassile, Jennifer R Lehman, Emma Harmon, Nancy Ferreira, Brittany Shinn, Nancy St James, Jacqueline Callender, Joel Stein
OBJECTIVE: Training and implementation for a multidisciplinary stroke rehabilitation method emphasizing procedural memory. BACKGROUND: Current practice in stroke rehabilitation relies on explicit memory, often compromised by stroke, failing to capitalize on better-preserved procedural memory skills. Recruitment of procedural memory requires consistency and practice, characteristics difficulty to promote on inpatient rehabilitation units. We designed a method Modified Approach to Stroke Rehabilitation (MAStR) to maximize consistency and practice for transfer training with stroke patients...
April 3, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29597247/home-hospitalization-for-acute-decompensated-heart-failure-opportunities-and-strategies-for-improved-health-outcomes
#4
REVIEW
Konstantinos V Voudris, Marc A Silver
IMPORTANCE: Heart failure (HF) is the leading cause of hospitalization among patients over the age of 65 in the United States and developed countries, posing a significant economic burden to the health care systems. More than half of the patients with HF will be readmitted to the hospital within 6 months from discharge, leading not only to increased health care related expenses but also functional decline, iatrogenic injuries and in-hospital infections. With the increasing prevalence of HF, there is a substantial need for innovative delivery care models that can provide hospital level of care at a patient's home...
March 28, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29590383/the-cox-maze-iv-procedure-in-its-second-decade-still-the-gold-standard
#5
Chawannuch Ruaengsri, Matthew R Schill, Ali J Khiabani, Richard B Schuessler, Spencer J Melby, Ralph J Damiano
Atrial fibrillation (AF) is the most common cardiac arrhythmia and the treatment options include medical treatment and catheter-based or surgical interventions. AF is a major cause of stroke, and its prevalence is increasing. The surgical treatment of AF has been revolutionized over the past 2 decades through surgical innovation and improvements in endoscopic imaging, ablation technology and surgical instrumentation. The Cox-maze (CM) procedure, which was developed by James Cox and introduced clinically in 1987, is a procedure in which multiple incisions are created in both the left and the right atria to eliminate AF while allowing the sinus impulse to reach the atrioventricular node...
April 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29581093/evolution-of-cognitive-rehabilitation-after-stroke-from-traditional-techniques-to-smart-and-personalized-home-based-information-and-communication-technology-systems-literature-review
#6
REVIEW
José M Cogollor, Javier Rojo-Lacal, Joachim Hermsdörfer, Manuel Ferre, Maria Teresa Arredondo Waldmeyer, Christos Giachritsis, Alan Armstrong, Jose Manuel Breñosa Martinez, Doris Anabelle Bautista Loza, José María Sebastián
BACKGROUND: Neurological patients after stroke usually present cognitive deficits that cause dependencies in their daily living. These deficits mainly affect the performance of some of their daily activities. For that reason, stroke patients need long-term processes for their cognitive rehabilitation. Considering that classical techniques are focused on acting as guides and are dependent on help from therapists, significant efforts are being made to improve current methodologies and to use eHealth and Web-based architectures to implement information and communication technology (ICT) systems that achieve reliable, personalized, and home-based platforms to increase efficiency and level of attractiveness for patients and carers...
March 26, 2018: JMIR rehabilitation and assistive technologies
https://www.readbyqxmd.com/read/29572814/a-person-centered-approach-to-poststroke-care-the-comprehensive-post-acute-stroke-services-model
#7
Cheryl D Bushnell, Pamela W Duncan, Sarah L Lycan, Christina N Condon, Amy M Pastva, Barbara J Lutz, Jacqueline R Halladay, Doyle M Cummings, Martinson K Arnan, Sara B Jones, Mysha E Sissine, Sylvia W Coleman, Anna M Johnson, Sabina B Gesell, Laurie H Mettam, Janet K Freburger, Blair Barton-Percival, Karen M Taylor, Janet Prvu-Bettger, Gladys Lundy-Lamm, Wayne D Rosamond
Many individuals who have had a stroke leave the hospital without postacute care services in place. Despite high risks of complications and readmission, there is no standard in the United States for postacute stroke care after discharge home. We describe the rationale and methods for the development of the COMprehensive Post-Acute Stroke Services (COMPASS) care model and the structure and quality metrics used for implementation. COMPASS, an innovative, comprehensive extension of the TRAnsition Coaching for Stroke (TRACS) program, is a clinician-led quality improvement model providing early supported discharge and transitional care for individuals who have had a stroke and have been discharged home...
March 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29567653/diagnosing-early-ischemic-changes-with-the-latest-generation-flat-detector-ct-a-comparative-study-with-multidetector-ct
#8
I L Maier, J R Leyhe, I Tsogkas, D Behme, K Schregel, M Knauth, M Schnieder, J Liman, M-N Psychogios
BACKGROUND AND PURPOSE: One-stop management of mechanical thrombectomy-eligible patients with large-vessel occlusion represents an innovative approach in acute stroke treatment. This approach reduces door-to-reperfusion times by omitting multidetector CT, using flat detector CT as pre-mechanical thrombectomy imaging. The purpose of this study was to compare the diagnostic performance of the latest-generation flat detector CT with multidetector CT. MATERIALS AND METHODS: Prospectively derived data from patients with ischemic stroke with large-vessel occlusion and mechanical thrombectomy were analyzed in this monocentric study...
March 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29549824/diverse-roles-of-mitochondria-in-ischemic-stroke
#9
REVIEW
Jenq-Lin Yang, Sujira Mukda, Shang-Der Chen
Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical outcomes. However, only a limited portion of patients receive thrombolytic therapy or endovascular treatment because the therapeutic time window after ischemic stroke is narrow. To address the current shortage of stroke management approaches, it is critical to identify new potential therapeutic targets...
March 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29540737/g-protein-coupled-receptor-gpr17-regulates-oligodendrocyte-differentiation-in-response-to-lysolecithin-induced-demyelination
#10
Changqing Lu, Lihua Dong, Hui Zhou, Qianmei Li, Guojiao Huang, Shu Jun Bai, Linchuan Liao
Oligodendrocytes are the myelin-producing cells of the central nervous system (CNS). A variety of brain disorders from "classical" demyelinating diseases, such as multiple sclerosis, stroke, schizophrenia, depression, Down syndrome and autism, are shown myelination defects. Oligodendrocyte myelination is regulated by a complex interplay of intrinsic, epigenetic and extrinsic factors. Gpr17 (G protein-coupled receptor 17) is a G protein-coupled receptor, and has been identified to be a regulator for oligodendrocyte development...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29534731/adaptation-and-post-adaptation-effects-of-haptic-forces-on-locomotion-in-healthy-young-adults
#11
Gianluca U Sorrento, Philippe S Archambault, Joyce Fung
BACKGROUND: Developing rehabilitation strategies to improve functional walking and postural control in patients is a priority for rehabilitation clinicians and researchers alike. One possible strategy is the use of sensory modalities to elicit adaptive locomotor gait patterns. This study aimed to explore to what extent haptic inputs, in the form of forward-leading tensile forces delivered to the hand, compared to no force, may lead to adaptation and post-adaptation effects on gait parameters, during and after the haptic exposure, respectively...
March 13, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29521890/neuroanesthesiology-update
#12
Jeffrey J Pasternak, William L Lanier
We provide a synopsis of innovative research, recurring themes, and novel experimental findings pertinent to the care of neurosurgical patients and critically ill patients with neurological diseases. We cover the following broad topics: general neurosurgery, spine surgery, stroke, traumatic brain injury, monitoring, and anesthetic neurotoxicity.
April 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29488903/assessment-of-ankle-muscle-activation-by-muscle-synergies-in-healthy-and-post-stroke-gait
#13
Qing Ji, Fei Wang, Rui Zhou, Jianhua Li, Jian Wang, Xuesong Ye
Impaired ankle dorsal and plantar flexor function is a frequent sequela of stroke. A better assessment of ankle muscle activation would be highly significant for stroke rehabilitation. The challenge in implementing current electromyography (EMG)-based assessments is due to problems with the variability and individuality of ankle muscle EMG profiles during walking. We have been studying a new technique using the muscle synergy method to quantify the characteristics that underlie ankle muscle activation to address this issue...
February 28, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29473778/assessment-of-the-praxis-circuit-in-glioma-surgery-to-reduce-the-incidence-of-postoperative-and-long-term-apraxia-a-new-intraoperative-test
#14
Marco Rossi, Luca Fornia, Guglielmo Puglisi, Antonella Leonetti, Gianmarco Zuccon, Enrica Fava, Daniela Milani, Alessandra Casarotti, Marco Riva, Federico Pessina, Gabriella Cerri, Lorenzo Bello
OBJECTIVE Apraxia is a cognitive-motor deficit affecting the execution of skilled movements, termed praxis gestures, in the absence of primary sensory or motor disorders. In patients affected by stroke, apraxia is associated with lesions of the lateral parietofrontal stream, connecting the posterior parietal areas with the ventrolateral premotor area and subserving sensory-motor integration for the hand movements. In the neurosurgical literature to date, there are few reports regarding the incidence of apraxia after glioma surgery...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29467715/limb-remote-ischemic-conditioning-mechanisms-anesthetics-and-the-potential-for-expanding-therapeutic-options
#15
REVIEW
Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Sylvain Doré
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29440902/chinese-calligraphy-handwriting-cch-a-case-of-rehabilitative-awakening-of-a-coma-patient-after-stroke
#16
Henry Sr Kao, Stewart Pw Lam, Tin Tin Kao
Introduction: This study investigated the efficacy of Chinese calligraphy handwriting (CCH) for the awakening of patients under a vegetative state after stroke. The theories, the instrument, and the treatment protocols were reported. A single case of a severe stroke patient who was in a coma state for 2 years is presented in this study. The objectives were to apply finger writing as a new method to awaken a stroke patient in a coma state and to test the effect of this method in improving the patient's vegetative states over time...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29427478/from-ruling-out-to-ruling-in-putting-pocus-in-focus
#17
Arjun K Venkatesh, Charles D Scales, Marta E Heilbrun
Over the past twenty years, the Emergency Department (ED) has transformed from a location that managed patients with acute life-threatening illness or injury to an acute diagnostic center. The advent of rapid and accurate imaging, novel biomarkers, and other innovations concurrent with effects from financial and social forces has supported the development of an acute care system focused on "ruling out" low-frequency, high-mortality events such as acute myocardial infarction, stroke, pulmonary embolism, and aortic dissection...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29417018/lacunae-in-noncommunicable-disease-control-program-need-to-focus-on-adherence-issues
#18
Tarundeep Singh, Nidhi Bhatnagar, Gopal Singh Moond
Introduction: Chronic non communicable diseases in India have increased in magnitude with earlier onset and more likelihood of complications. Much emphasis is given to early diagnosis and timely treatment. Additionally, tertiary prevention through medication adherence is needed to limit disability and prevent early onset of complications. This study was aimed to assess the magnitude of medication and lifestyle adherence among elderly patients suffering from diabetes and hypertension in rural areas of Punjab...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29400670/upper-limb-robot-assisted-therapy-in-subacute-and-chronic-stroke-patients-using-an-innovative-end-effector-haptic-device-a-pilot-study
#19
S Mazzoleni, E Battini, R Crecchi, P Dario, F Posteraro
BACKGROUND: Significant results have been shown when an upper limb robot-assisted rehabilitation is delivered to stroke patients. OBJECTIVE: To evaluate the effects of upper limb robot-assisted rehabilitation on motor recovery in stroke patients who underwent a treatment based on a haptic device. METHODS: Thirty-nine stroke patients (twenty-three subacute and sixteen chronic) underwent rehabilitation training by using MOTORE/Armotion haptic system...
2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29385923/high-intensity-focused-ultrasound-past-present-and-future-in-neurosurgery
#20
Syed A Quadri, Muhammad Waqas, Inamullah Khan, Muhammad Adnan Khan, Sajid S Suriya, Mudassir Farooqui, Brian Fiani
Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologists, or even neurosurgeons are familiar with it...
February 2018: Neurosurgical Focus
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