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Stroke innovation

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https://www.readbyqxmd.com/read/29150450/aerobic-power-and-flight-capacity-in-birds-a-phylogenetic-test-of-the-heart-size-hypothesis
#1
Roberto F Nespolo, César González-Lagos, Jaiber J Solano-Iguaran, Magnus Elfwing, Alvaro Garitano-Zavala, Santiago Mañosa, Juan Carlos Alonso, Jordi Altimiras
Flight capacity is one of the most important innovations in animal evolution; it only evolved in insects, birds, mammals and the extinct pterodactyls. Given that powered flight represents a demanding aerobic activity, an efficient cardiovascular system is essential for the continuous delivery of oxygen to the pectoral muscles during flight. It is well known that the limiting step in the circulation is stroke volume (the volume of blood pumped from the ventricle to the body during each beat), which is determined by the size of the ventricle...
November 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29147858/community-interventions-to-increase-stroke-preparedness-and-acute-stroke-treatment-rates
#2
REVIEW
Kathleen M Kelly, Kathryn T Holt, Gina M Neshewat, Lesli E Skolarus
PURPOSE OF REVIEW: Acute stroke treatments reduce the risk of post-stroke disability. These treatments, tissue plasminogen activator (tPA) and intra-arterial treatment, are highly time-dependent; thus, one of the main barriers to treatment is pre-hospital delay. Stroke preparedness is defined as the ability to recognize stroke symptoms and the intent to activate emergency medical services (EMS). This review describes types of acute stroke treatment and preparedness interventions, including recent mass media interventions to increase acute stroke treatment rates, and adult and youth community interventions to increase stroke preparedness...
November 16, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29140675/identification-of-novel-allosteric-modulators-of-glutamate-transporter-eaat2
#3
Sandhya Kortagere, Ole Valente Mortensen, Jingsheng Xia, William Lester, Yuhong Fang, Yellamelli V V Srikanth, Joseph M Salvino, Andreia Cristina Karklin Fontana
Dysfunction of excitatory amino acid transporters (EAATs) has been implicated in the pathogenesis of various neurological disorders, such as stroke, brain trauma, epilepsyand neurodegenerative diseases among others. EAAT2 is the main subtype responsible for glutamate clearance in the brain, having a key role in regulating transmission and preventing excitotoxicity. Therefore, compounds that increase the expression or activity of EAAT2 have therapeutic potential for neuroprotection. Previous studies identified molecular determinants for EAAT2 transport stimulation in a structural domain that lies at the interface of the rigid trimerization domain and the central substrate binding transport domain...
November 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29104807/neural-vascular-mechanism-for-the-cerebral-blood-flow-autoregulation-after-hemorrhagic-stroke
#4
REVIEW
Ming Xiao, Qiang Li, Hua Feng, Le Zhang, Yujie Chen
During the initial stages of hemorrhagic stroke, including intracerebral hemorrhage and subarachnoid hemorrhage, the reflex mechanisms are activated to protect cerebral perfusion, but secondary dysfunction of cerebral flow autoregulation will eventually reduce global cerebral blood flow and the delivery of metabolic substrates, leading to generalized cerebral ischemia, hypoxia, and ultimately, neuronal cell death. Cerebral blood flow is controlled by various regulatory mechanisms, including prevailing arterial pressure, intracranial pressure, arterial blood gases, neural activity, and metabolic demand...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29077930/are-data-from-national-quality-registries-used-in-quality-improvement-at-swedish-hospital-clinics
#5
Mio Fredriksson, Christina Halford, Ann Catrine Eldh, Tobias Dahlström, Sofie Vengberg, Lars Wallin, Ulrika Winblad
Objective: To investigate the use of data from national quality registries (NQRs) in local quality improvement as well as purported key factors for effective clinical use in Sweden. Design: Comparative descriptive: a web survey of all Swedish hospitals participating in three NQRs with different levels of development (certification level). Setting and Participants: Heads of the clinics and physician(s) at clinics participating in the Swedish Stroke Register (Riksstroke), the Swedish National Registry of Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography (GallRiks) and the Swedish Lung Cancer Registry (NLCR)...
October 25, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29060204/movement-related-brain-oscillations-vary-with-lesion-location-in-severely-paralyzed-chronic-stroke-patients
#6
Andreas M Ray, Eduardo Lopez-Larraz, Thiago C Figueiredo, Niels Birbaumer, Ander Ramos-Murguialday
In the past few years, innovative upper-limb rehabilitation methods have been proposed for chronic stroke patients. These methods aim at functional motor rehabilitation using Brain-machine interfaces to constitute an alternate pathway from the brain to the muscles. Even in patients with absence of residual finger movements, recovery could be achieved. The extent to which these interventions are affected by individual lesion topology is yet to be understood. In this study EEG was measured in 30 chronic stroke patients during movement attempts of the paretic arm...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057269/combining-upper-limb-robotic-rehabilitation-with-other-therapeutic-approaches-after-stroke-current-status-rationale-and-challenges
#7
REVIEW
Stefano Mazzoleni, Christophe Duret, Anne Gaëlle Grosmaire, Elena Battini
A better understanding of the neural substrates that underlie motor recovery after stroke has led to the development of innovative rehabilitation strategies and tools that incorporate key elements of motor skill relearning, that is, intensive motor training involving goal-oriented repeated movements. Robotic devices for the upper limb are increasingly used in rehabilitation. Studies have demonstrated the effectiveness of these devices in reducing motor impairments, but less so for the improvement of upper limb function...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29055405/traumatic-brain-injury-diabetic-neuropathy-and-altered-psychiatric-health-the-fateful-triangle
#8
Hadi Abou-El-Hassan, Batoul Dia, Khalil Choucair, Stephanie A Eid, Farah Najdi, Lama Baki, Farid Talih, Assaad A Eid, Firas Kobeissy
Traumatic brain injury is a detrimental medical condition particularly when accompanied by diabetes. There are several comorbidities going along with diabetes including, but not limited to, kidney failure, obesity, coronary artery disease, peripheral vascular disease, hypertension, stroke, neuropathies and amputations. Unlike diabetes type 1, diabetes type 2 is more common in adults who simultaneously suffer from other comorbid conditions making them susceptible to repetitive fall incidents and sustaining head trauma...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29039291/asset-literacy-following-stroke-implications-for-disaster-resilience
#9
Tracey L O'Sullivan, Christine Fahim, Elizabeth Gagnon
OBJECTIVE: The World Stroke Organization "1 in 6" campaign aims to raise awareness that 1 in 6 persons will experience a stroke during their lifetime. With aging populations and improved survival rates, an increased number of survivors live with functional limitations and require supportive care. This has important implications for implementing an all-of-society approach to disaster risk reduction. In this study, we explore the assets that stroke survivors and caregivers consider useful in supporting their capacity to manage routine activities and independent living and to respond to a disaster...
October 17, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29033109/three-years-of-the-nationwide-post-acute-stroke-care-program-in-taiwan
#10
Cheng-Yang Hsieh, Wei-Chia Tsao, Ruey-Tay Lin, A-Ching Chao
Prolonged hospital stay and readmission are prevalent problems for stroke patients in Taiwan after the acute stage, partly due to the unmet need of post-acute care. In March 2014, Taiwan's National Health Insurance Administration launched a nationwide Post-Acute Care-CerebroVascular Disease (PAC-CVD) program. The Taiwan Stroke Society, coordinating 11 allied disciplines, took responsibility for the preparation and implementation of the program. As of June 2016, 6839 consecutive stroke patients were enrolled...
October 9, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29024265/effectiveness-of-a-handmade-new-carotid-catheter-in-transradial-carotid-angiography-a-comparison-with-conventional-multipurpose-catheters
#11
Yakup Balaban
OBJECTIVE: The incidence and severity of carotid atherosclerosis increases in proportion with coronary artery disease and its severity. A special catheter specifically used for transradial carotid angiography has not yet been marketed. In this study, we investigate the feasibility and safety of our carotid catheter, which was made by reshaping currently available catheters. METHODS: Between 2010 and 2017, a total of 921 patients with indications for carotid angiography were identified after angiographic examinations and included in the study...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28990420/synaptic-activity-protects-neurons-against-calcium-mediated-oxidation-and-contraction-of-mitochondria-during-excitotoxicity
#12
Constanze Depp, Carlos Bas-Orth, Lisa Schroeder, Andrea Hellwig, Hilmar Bading
AIMS: Excitotoxicity triggered by extrasynaptic N-methyl-d-aspartate-type glutamate receptors has been implicated in many neurodegenerative conditions, including Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke. Mitochondrial calcium overload leading to mitochondrial dysfunction represents an early event in excitotoxicity. Neurons are rendered resistant to excitotoxicity by previous periods of synaptic activity that activates a nuclear calcium-driven neuroprotective gene program...
November 14, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28962493/first-results-of-heartware-left-ventricular-assist-device-implantation-with-tunnelling-of-the-outflow-graft-through-the-transverse-sinus
#13
Jasmin S Hanke, Sebastian V Rojas, Tomislav Cvitkovic, Bettina Wiegmann, Alexander Horke, Gregor Warnecke, Axel Haverich, Jan D Schmitto
OBJECTIVES: The number of left ventricular assist device (LVAD) implants for the treatment of advanced heart failure is increasing tremendously. The main therapeutic goal of this operation is to provide a bridge to transplant for patients awaiting a donor heart. In 2011, we developed a novel, minimally invasive surgical technique for LVAD implantation. To avoid possible outflow graft injuries during redo sternotomies as well as to provide a more physiological outflow towards the aortic arch, a further modification of this approach was made with outflow graft tunnelling through the transverse sinus...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28961089/on-the-verge-of-neuro-motion-chad-bouton-and-his-team-are-developing-breakthrough-neural-decoding-methods-that-help-people-with-paralysis-move-again
#14
Cynthia Weber
Chad Bouton, director of the Center for Bioelectronic Medicine and vice president of advanced engineering at the Feinstein Institute for Medical Research, which serves as the research arm of one of the largest health systems in the United States, has spent nearly two decades developing innovative medical technology and products that help diagnose and treat conditions including cancer, stroke, diabetes, and paralysis. Last year, in a groundbreaking effort, Bouton and his colleagues published their findings in Nature on neural-decoding methods that helped Ian Burkhart become the first paralyzed person with a brain implant to move again with his own thoughts...
September 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28955382/atrial-fibrillation-in-heart-failure-a-therapeutic-challenge-of-our-times
#15
REVIEW
Syeda Atiqa Batul, Rakesh Gopinathannair
Atrial fibrillation (AF) and heart failure (HF) are growing cardiovascular disease epidemics worldwide. There has been an exponential increase in the prevalence of AF and HF correlating with an increased burden of cardiac risk factors and improved survival rates in patients with structural heart disease. AF is associated with adverse prognostic outcomes in HF and is most evident in mild-to-moderate left ventricular (LV) dysfunction where the loss of "atrial kick" translates into poorer quality of life and increased mortality...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28936594/transcatheter-aortic-valve-replacement-outcomes-indications-complications-and-innovations
#16
REVIEW
Michael N Young, Ignacio Inglessis
Transcatheter aortic valve replacement (TAVR) has become the standard of care for the treatment of severe aortic stenosis in individuals who are at prohibitive surgical risk and presents a viable alternative to surgery in selected patients who are at high operative risk. To date, outcomes from the PARTNER (Placement of AoRtic TraNscathetER Valve) and Medtronic CoreValve® US Pivotal trials continue to show the benefits of TAVR in these high-risk subgroups out to 5 and 3 years, respectively (as reported by Mack et al...
September 22, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28901219/primary-prevention-of-stroke-and-cardiovascular-disease-in-the-community-prevents-methodology-of-a-health-wellness-coaching-intervention-to-reduce-stroke-and-cardiovascular-disease-risk-a-randomized-clinical-trial
#17
Susan Mahon, Rita Krishnamurthi, Alain Vandal, Emma Witt, Suzanne Barker-Collo, Priya Parmar, Alice Theadom, Alan Barber, Bruce Arroll, Elaine Rush, Hinemoa Elder, Jesse Dyer, Valery Feigin
Rationale Stroke is a major cause of death and disability worldwide, yet 80% of strokes can be prevented through modifications of risk factors and lifestyle and by medication. While management strategies for primary stroke prevention in high cardiovascular disease risk individuals are well established, they are underutilized and existing practice of primary stroke prevention are inadequate. Behavioral interventions are emerging as highly promising strategies to improve cardiovascular disease risk factor management...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28859664/synergistic-effects-of-aerobic-exercise-and-cognitive-training-on-cognition-physiological-markers-daily-function-and-quality-of-life-in-stroke-survivors-with-cognitive-decline-study-protocol-for-a-randomized-controlled-trial
#18
Ting-Ting Yeh, Ching-Yi Wu, Yu-Wei Hsieh, Ku-Chou Chang, Lin-Chien Lee, Jen-Wen Hung, Keh-Chung Lin, Ching-Hung Teng, Yi-Han Liao
BACKGROUND: Aerobic exercise and cognitive training have been effective in improving cognitive functions; however, whether the combination of these two can further enhance cognition and clinical outcomes in stroke survivors with cognitive decline remains unknown. This study aimed to determine the treatment effects of a sequential combination of aerobic exercise and cognitive training on cognitive function and clinical outcomes. METHODS/DESIGN: Stroke survivors (n = 75) with cognitive decline will be recruited and randomly assigned to cognitive training, aerobic exercise, and sequential combination of aerobic exercise and cognitive training groups...
August 31, 2017: Trials
https://www.readbyqxmd.com/read/28845355/improving-population-health-through-an-innovative-collaborative-the-be-there-san-diego-data-for-quality-group
#19
Allen Fremont, Ashley M Kranz, Jessica Phillips, Chandra Garber
In 2012, leaders from disparate health care organizations established a data group aligned around a regional goal of preventing heart attacks and strokes in San Diego. The group---now named the Be There San Diego Data for Quality (DFQ) Group---is a safe venue for medical directors and other quality-improvement leaders to share performance data on quality-of-care measures for diabetes, hypertension, and cardiovascular disease, as well as insights, lessons learned, and challenges faced by each organization in treating these conditions...
June 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28841580/durable-biventricular-support-using-right-atrial-placement-of-the-heartware-hvad
#20
Hao A Tran, Travis L Pollema, Jorge Silva Enciso, Barry H Greenberg, Denise D Barnard, Eric D Adler, Victor G Pretorius
Patients with Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) levels 1-2 who either have or are at risk for right ventricular failure face significant morbidity and mortality after continuous flow left ventricular assist device (CF-LVAD) implantation. Currently, the options for biventricular support are limited the Total Artificial Heart (TAH; CardioWest, Syncardia, Tuscon, AZ) or biventricular assist device (BiVAD), which uses bulky extracorporeal or implantable displacement pumps...
August 23, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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