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https://www.readbyqxmd.com/read/29351815/ready-to-use-protein-g-conjugated-gold-nanorods-for-biosensing-and-biomedical-applications
#1
S Centi, F Ratto, F Tatini, S Lai, R Pini
BACKGROUND: Gold nanorods (GNRs) display unique capacity to absorb and scatter near infrared light, which arises from their peculiar composition of surface plasmon resonances. For this reason, GNRs have become an innovative material of great hope in nanomedicine, in particular for imaging and therapy of cancer, as well as in photonic sensing of biological agents and toxic compounds for e.g. biomedical diagnostics, forensic analysis and environmental monitoring. As the use of GNRs is becoming more and more popular, in all these contexts, there is emerging a latent need for simple and versatile protocols for their modification with targeting units that may convey high specificity for any analyte of interest of an end-user...
January 19, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29350522/chemical-design-of-both-a-glutathione-sensitive-dimeric-drug-guest-and-a-glucose-derived-nanocarrier-host-to-achieve-enhanced-osteosarcoma-lung-metastatic-anticancer-selectivity
#2
Lu Su, Richen Li, Sarosh Khan, Ryan Clanton, Fuwu Zhang, Yen-Nan Lin, Yue Song, Hai Wang, Jingwei Fan, Soleil Hernandez, Andrew S Butters, Gamal Akabani, Ronan MacLoughlin, Justin Smolen, Karen L Wooley
Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and drug carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers and one dimeric prodrug molecule were designed to be coassembled into degradable, functional nanocarriers, where the chemistry of each component was defined to accomplish important tasks. The result is a poly(ethylene glycol) (PEG)-protected redox-responsive dimeric paclitaxel (diPTX)-loaded cationic poly(d-glucose carbonate) micelle (diPTX@CPGC)...
January 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29350484/paraptosis-inducing-nanomedicine-overcomes-cancer-drug-resistance-for-a-potent-cancer-therapy
#3
Yongcun Zhou, Feiteng Huang, Ying Yang, Pingli Wang, Zhen Zhang, Yining Tang, Youqing Shen, Kai Wang
Most chemotherapeutic drugs and their nanomedicine formulations exert anticancer activity by inducing cancer cell apoptosis. However, cancer cells inherently have and acquire many antiapoptosis mechanisms, causing cancer drug resistance and poor prognoses in patients. Herein, a potent paraptosis-inducing nanomedicine is reported that causes quick nonapoptotic death of cancer cells, overcoming apoptosis-based resistance and effectively inhibiting drug-resistant tumor growth. The nanomedicine is composed of micelles made from an amphiphilic 8-hydroxyquinoline (HQ)-conjugate block copolymer with polyethylene glycol...
January 19, 2018: Small
https://www.readbyqxmd.com/read/29350186/mri-tracing-non-invasive-tio2-based-nanoparticles-motivated-by-ultrasound-for-multi-mechanism-therapy-of-prostatic-cancer
#4
Pu Yuan, Dongkui Song
To reduce the side effects of chemotherapy and reach effective and safe therapy of prostate cancer, herein, a simple but multifunctional system TiO2:Gd@DOX/FA motivated by ultrasound was developed for MRI guided multi-mechanism therapy of prostate cancer. TiO2 nanoparticles served as a sonosensitizer as well as a nanocarrier with pH-responsive release of DOX. Doping of Gd could not only endow TiO2 the ability of magnetic resonance imaging (MRI), but also further improve sonodynamic ability of TiO2. The characterization revealed the as-prepared TiO2:Gd@DOX/FA showed sensitive pH-responsive drug release, high ROS production, T1-MRI contrast performance and excellent biocompatibility...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29349918/dual-drug-backboned-shattering-polymeric-theranostic-nanomedicine-for-synergistic-eradication-of-patient-derived-lung-cancer
#5
Yuwei Cong, Haihua Xiao, Hejian Xiong, Zigui Wang, Jianxun Ding, Chan Li, Xuesi Chen, Xing-Jie Liang, Dongfang Zhou, Yubin Huang
Most of the current nanoparticle-based therapeutics worldwide failing in clinical trials face three major challenges: (i) lack of an optimum drug delivery platform with precise composition, (ii) lack of a method of directly monitoring the fate of a specific drug rather than using any other labelling molecules as a compromise, and (iii) lack of reliable cancer models with high fidelity for drug screen and evaluation. Here, starting from a PP2A inhibitor demethylcantharidin (DMC) and cisplatin, the design of a dual sensitive dual drug backboned shattering polymer (DDBSP) with exact composition at a fixed DMC/Pt ratio for precise nanomedicine is shown...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29344305/a-tumor-activatable-theranostic-nanomedicine-platform-for-nir-fluorescence-guided-surgery-and-combinatorial-phototherapy
#6
Xiaoning Li, Canan Schumann, Hassan A Albarqi, Christopher J Lee, Adam W G Alani, Shay Bracha, Milan Milovancev, Olena Taratula, Oleh Taratula
Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29342359/semiconducting-photothermal-nanoagonist-for-remote-controlled-specific-cancer-therapy
#7
Xu Zhen, Chen Xie, Yuyan Jiang, Xiangzhao Ai, Bengang Xing, Kanyi Pu
Nanomedicines have shown success in cancer therapy, but the pharmacological actions of most nanomedicine are often nonspecific to cancer cells because of utilization of the therapeutic agents that induce cell apoptosis from inner organelles. We herein report the development of semiconducting photothermal nanoagonists that can remotely and specifically initiate the apoptosis of cancer cells from cell membrane. The organic nanoagonists comprise semiconducting polymer nanoparticles (SPNs) and capsaicin (Cap) as the photothermally-responsive nanocarrier and the agonist for activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), respectively...
January 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29336520/near-infrared-triggered-decomposition-of-nanocapsules-with-high-tumor-accumulation-and-stimuli-responsive-fast-elimination
#8
Dongyuan Zhao, Tiancong Zhao, Peiyuan Wang, Qin Li, Areej Abdulkareem Al-Khalaf, Wael N Hozzein, Fan Zhang, Xiaomin Li
Nanoparticle based diagnosis-therapy integrative systems represent an emerging approach to cancer treatment. However, a series of size-dependent biological barriers impede nanomedicine from clinical implementation, especially the contradiction on optimum sizes for long blood circulation and quick metabolization. Herein, we demonstrate a novel NIR induced decomposable nanocapsule. The nanocapsules are fabricated based on layer-by-layer assembly of azobenzene functionalized polymers and up/downconversion nanoparticles (U/DCNPs)...
January 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29334759/redox-nano-architectures-perspectives-and-implications-in-diagnosis-and-treatment-of-human-diseases
#9
Shamim Akhtar Sufi, Sankar Pajaniradje, Victor Mukherjee, Rukkumani Rajagopalan
Significance - Efficient targeted therapy with minimal side effects is the need of the hour.. Locally altered redox state is observed in several human ailments, such as inflammation, sepsis, and cancer. This has been taken advantage in designing redox-responsive nano-drug carriers. Redox-responsive nanosystems open a door to multitude of possibilities for the control of diseases over other drug delivery systems. Recent Advances -The first generation nanotherapy relies on novel properties of nanomaterials to shield the drug and deliver it to the diseased tissue or organ...
January 15, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29334095/gd3-doped-mose2-nanosheets-used-as-a-theranostic-agent-for-bimodal-imaging-and-highly-efficient-photothermal-cancer-therapy
#10
Jiali Pan, Xufeng Zhu, Xu Chen, Yingyu Zhao, Jie Liu
Recently, two dimensional transition metal dichalcogenides (TMDCs) being used as nanomedicine have aroused great interest because of their unique photothermal properties. A simple liquid-phase method was used to prepare gadolinium (Gd3+)-doped molybdenum selenide (MoSe2) nanosheets, and then using poly(ethylene glycol) (PEG) modification on the surface, MoSe2(Gd3+)-PEG nanosheets were obtained which had high stability in physiological solutions and showed no obvious toxicity in vivo. It revealed that Gd3+ used as a paramagnetic material for MoSe2(Gd3+)-PEG provided a strong contrast effect in magnetic resonance imaging, furthermore, the MoSe2 showed strong absorption in the near infrared region, and therefore, MoSe2(Gd3+)-PEG could be used as contrast agent for photoacoustic imaging (PAI)...
January 15, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29333729/immunoengineering-with-biomaterials-for-enhanced-cancer-immunotherapy
#11
REVIEW
Yu-Qing Xie, Lixia Wei, Li Tang
Cancer immunotherapy has recently shown dramatic clinical success inducing durable response in patients of a wide variety of malignancies. Further improvement of the clinical outcome with immune related cancer treatment requests more exquisite manipulation of a patient's immune system with increased immunity against diseases while mitigating the toxicities. To meet this challenge, biomaterials applied to immunoengineering are being developed to achieve tissue- and/or cell-specific immunomodulation and thus could potentially enhance both the efficacy and safety of current cancer immunotherapies...
January 14, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29333658/in-situ-shrna-synthesis-on-dna-polylactide-nanoparticles-to-treat-multidrug-resistant-breast-cancer
#12
Qianqian Ni, Fuwu Zhang, Yunlei Zhang, Guizhi Zhu, Zhe Wang, Zhaogang Teng, Chunyan Wang, Bryant C Yung, Gang Niu, Guangming Lu, Longjiang Zhang, Xiaoyuan Chen
Nanomedicine has shown unprecedented potential for cancer theranostics. Nucleic acid (e.g., DNA and RNA) nanomedicines are of particular interest for combination therapy with chemotherapeutics. However, current nanotechnologies to construct such nucleic acid nanomedicines, which rely on chemical conjugation or physical complexation of nucleic acids with chemotherapeutics, have restrained their clinical translation due to limitations such as low drug loading efficiency and poor biostability. Herein, in situ rolling circle transcription (RCT) is applied to synthesize short hairpin RNA (shRNA) on amphiphilic DNA-polylactide (PLA) micelles...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29332566/stimuli-responsive-nanoparticles-for-controlled-anti-cancer-drug-release
#13
Qi Tang, Bing Yu, Lilong Gao, Hailin Cong, Na Song, Chenghao Lu
Conventional drugs used for cancer chemotherapy have severe toxic side effects and show individually varied therapeutic responses. The convergence of nanotechnology, biology, material science and pharmacy offers a perspective strategy for cancer chemotherapy. Nanoparticles loaded with anti-cancer drug have been designed to overcome the limitations associated with conventional drugs, several nanomedicines have been approved by FDA and shown good performances in clinical practice. However, the therapeutic efficacies cannot be enhanced...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29323870/cell-membrane-bioconjugation-and-membrane-derived-nanomaterials-for-immunotherapy
#14
Peter Y Li, Zhiyuan Fan, Hao Cheng
Cell membrane engineering, including live cell membrane bioconjugation and cell membrane-derived nanomaterials is a highly promising strategy to modulate immune responses for treating diseases. Many cell membrane engineering methods have potential for translation for human clinical use in the near future. In this Topical Review, we summarize the cell membrane conjugation strategies that have been investigated for cancer immunotherapy, the prevention of immune rejection to donor cells and tissues, and the induction of antigen-specific tolerance in autoimmune diseases...
January 11, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29318963/nanodiagnostics-and-nanodelivery-applications-in-genetic-alterations
#15
Maria Sofia Falzarano, Cristina Flesia, Roberta Cavalli, Caterina Guiot, Alessandra Ferlini
Background Genetic alterations cause hereditary diseases (HDs) with a wide range of incidences. Some, like cystic fibrosi, occur frequently (1/1,000 newborns), whilst others, such as Pompe disease and other metabolic disorders are very rare (1/100,000 newborns). They are well under the threshold of 1/3,000, denoted by the European Community as rare diseases (RDs). Genetic alterations are also associated with multifactorial disorders like diabetes, and underline both somatic and germline mutations in cancer...
January 10, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29316094/integrated-multifunctional-micelles-co-self-assembled-from-polypeptides-conjugated-with-natural-ferulic-acid-and-lipoic-acid-for-efficient-and-bioresponsive-doxorubicin-delivery
#16
Zhiyuan Zhong, Tao Chen, Min Qiu, Jian Zhang, Huanli Sun, Chao Deng
How to develop safe, easily accessible, and multifunctional nanocarriers is a big theme for nanomedicine research. Here, integrated multifunctional micelles (IMM) were developed by co-self-assembly of poly(ethylene glycol)-b-poly(L-lysine) derivatives with natural ferulic acid or lipoic acid. FA confers IMM with intrinsic antitumor activity, improved loading of doxorubicin (DOX) via π-π stacking, and reduced DOX cardiotoxicity. LA provides IMM with reversible crosslinking property which leads to a high colloidal stability with inhibited drug leakage and triggered intracellular DOX release...
January 9, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29315862/toxic-reactive-oxygen-species-enhanced-synergistic-combination-therapy-by-self-assembled-metal-phenolic-network-nanoparticles
#17
Yunlu Dai, Zhen Yang, Siyuan Cheng, Zhongliang Wang, Ruili Zhang, Guizhi Zhu, Zhantong Wang, Bryant C Yung, Rui Tian, Orit Jacobson, Can Xu, Qianqian Ni, Jibin Song, Xiaolian Sun, Gang Niu, Xiaoyuan Chen
Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via a biocompatible metal-polyphenol networks self-assembly process by encapsulating doxorubicin (DOX) and platinum prodrugs in nanoparticles. Both DOX and platinum drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide radicals (O2•- )...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29313660/enhancing-the-efficacy-and-safety-of-doxorubicin-against-hepatocellular-carcinoma-through-a-modular-assembly-approach-the-combination-of-polymeric-prodrug-design-nanoparticle-encapsulation-and-cancer-cell-specific-drug-targeting
#18
Li Xu, Shengjun Xu, Hangxiang Wang, Jun Zhang, Zun Chen, Linhui Pan, Jianguo Wang, Xuyong Wei, Hai-Yang Xie, Lin Zhou, Shusen Zheng, Xiao Xu
Intervention is urgently required to improve the therapeutic outcome for patients with unresectable hepatocellular carcinomas (HCCs). However, current chemotherapeutics, such as sorafenib and doxorubicin (DOX), provide only limited therapeutic benefits for this devastating disease. In this context, we present a modular assembly approach to the construction of a systemically injectable nanotherapeutic that can efficiently and safely deliver DOX in vivo. To achieve this goal, we covalently attached DOX to a polylactide (PLA) building block (Mw = 2600, n = 36), yielding DOX-PLA conjugate 1...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29305718/synthesis-characterization-and-evaluation-of-antimicrobial-and-cytotoxic-activities-of-biogenic-silver-nanoparticles-synthesized-from-streptomyces-xinghaiensis-of1-strain
#19
Magdalena Wypij, Joanna Czarnecka, Magdalena Świecimska, Hanna Dahm, Mahendra Rai, Patrycja Golinska
We report synthesis of silver nanoparticles (AgNPs) from Streptomyces xinghaiensis OF1 strain, which were characterised by UV-Vis and Fourier transform infrared spectroscopy, Zeta sizer, Nano tracking analyser, and Transmission electron microscopy. The antimicrobial activity of AgNPs alone, and in combination with antibiotics was evaluated against bacteria, namely Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis, and yeasts viz., Candida albicans and Malassezia furfur by using micro-dilution method...
January 5, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29303196/biodegradable-moox-nanoparticles-with-efficient-near-infrared-photothermal-and-photodynamic-synergetic-cancer-therapy-at-the-second-biological-window
#20
Wenyan Yin, Tao Bao, Xiao Zhang, Qin Gao, Jie Yu, Xinghua Dong, Liang Yan, Zhanjun Gu, Yuliang Zhao
Near-infrared (NIR) laser induced phototherapy has been considered as a noninvasive option for cancer therapy. Herein, we report plasmonic PEGylated molybdenum oxide nanoparticles (PEG-MoOx NPs) that were synthesized by using a facile hydrothermal method. The PEG-MoOx NPs exhibit broad absorption at the NIR biological window and remarkable photothermal conversion ability in the first (808 nm) and the second (1064 nm) windows. Moreover, the biocompatible PEG-MoOx NPs exhibit effective cellular uptake and could be eliminated gradually from the liver and spleen in mice...
January 5, 2018: Nanoscale
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