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cancer nanomedicine

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https://www.readbyqxmd.com/read/28533174/how-should-we-plan-the-future-of-nanomedicine-for-cancer-diagnosis-and-therapy
#1
EDITORIAL
Khair Alhareth, Lucie Sancey, Nicolas Tsapis, Nathalie Mignet
No abstract text is available yet for this article.
May 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28531102/nanoparticles-as-theranostic-vehicles-in-experimental-and-clinical-applications-focus-on-prostate-and-breast-cancer
#2
REVIEW
Jörgen Elgqvist
Prostate and breast cancer are the second most and most commonly diagnosed cancer in men and women worldwide, respectively. The American Cancer Society estimates that during 2016 in the USA around 430,000 individuals were diagnosed with one of these two types of cancers, and approximately 15% of them will die from the disease. In Europe, the rate of incidences and deaths are similar to those in the USA. Several different more or less successful diagnostic and therapeutic approaches have been developed and evaluated in order to tackle this issue and thereby decrease the death rates...
May 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28530541/synthesis-of-new-antibacterial-cubane-based-nanocomposite-and-its-application-in-combination-cancer-therapy
#3
Elham Zakerzadeh, Roya Salehi, Mehrdad Mahkam
BACKGROUND: The need for therapeutically effective anticancer drug delivery systems constantly persuades researchers to explore novel strategies. OBJECTIVE: In this study a novel cubane based antibacterial nanocomposite was tailored as dual chemotherapy drug delivery vesicle in order to increase the therapeutic outcome in cancer therapy. METHOD: The physico-chemical characterization of engineered nanocarrier was assessed by Fourier transforms infrared spectroscopy (FTIR), Hydrogen nuclear magnetic resonance spectroscopy (1H NMR), Thermogravimetric analysis (TGA), and Field emission scanning electron microscopy-energy dispersive using X-ray (FESEM-EDX)...
May 22, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28529648/elongated-nanoparticle-aggregates-in-cancer-cells-for-mechanical-destruction-with-low-frequency-rotating-magnetic-field
#4
Yajing Shen, Congyu Wu, Taro Q P Uyeda, Gustavo R Plaza, Bin Liu, Yu Han, Maciej S Lesniak, Yu Cheng
Magnetic nanoparticles (MNPs) functionalized with targeting moieties can recognize specific cell components and induce mechanical actuation under magnetic field. Their size is adequate for reaching tumors and targeting cancer cells. However, due to the nanometric size, the force generated by MNPs is smaller than the force required for largely disrupting key components of cells. Here, we show the magnetic assembly process of the nanoparticles inside the cells, to form elongated aggregates with the size required to produce elevated mechanical forces...
2017: Theranostics
https://www.readbyqxmd.com/read/28525949/capsaicin-loaded-folic-acid-conjugated-lipid-nanoparticles-for-enhanced-therapeutic-efficacy-in-ovarian-cancers
#5
Lin Lv, Yu-Xin Zhuang, Hui-Wu Zhang, Nan-Nan Tian, Wen-Zhen Dang, Shao-Yu Wu
In this study, folic acid-conjugated lipid nanoparticles were successfully prepared to enhance the active targeting of capsaicin (CAP) in ovarian cancers. The particles were nanosized and exhibited a controlled release of drug in the physiological conditions. The folic acid (FA)-conjugated system exhibited a remarkably higher uptake of nanoparticles in the cancer cells compared to that of non-targeted system. The folate-conjugated CAP-loaded lipid nanoparticles (CFLN) upon interacting with cancer cells were internalized via receptor-mediated endocytosis mechanism and resulted in higher concentration in the cancer cells...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28522193/ph-triggered-re-assembly-of-nanosphere-to-nanofiber-the-role-of-peptide-conformational-change-for-enhanced-cancer-therapy
#6
Peiqing Liang, Junjiong Zheng, Shulin Dai, Jiayu Wang, Zhaoqing Zhang, Ting Kang, Changyun Quan
pH-triggered conformational change and subsequent re-assembly of nanostructures provide a new strategy in nanomedicine for controlled drug release and enhanced therapy. Here, we reported the development of a novel pH-responsive nano-assembly as a drug carrier from peptide amphiphile (PA) consisting of mimicking peptide and stearic acid moieties. The mimicking peptide is a basic 17-amino acid peptide derived from antennapedia homeodomain, and undergoes a conformational transition of the secondary structure from β-sheet at pH7...
May 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28520436/controlling-structure-and-function-of-polymeric-drug-delivery-nanoparticles-using-microfluidics
#7
Aman Bains, Yimeng Cao, Sundiata Kly, Jeremy E Wulff, Matthew G Moffitt
We demonstrate control of multiscale structure and drug delivery function for paclitaxel (PAX)-loaded polycaprolactone-block-poly(ethylene oxide) (PCL-b-PEO) polymeric nanoparticles (PNPs) via synthesis and flow-directed shear processing in a two-phase gas-liquid microfluidic reactor. This strategy takes a page from the engineering of commodity plastics, where processing rather than polymer chemistry provides an experimental handle on properties and function. PNPs formed from copolymers with three different PCL block lengths show sizes, morphologies, and loading efficiencies that depend on both the PCL block length and the microfluidic flow rate...
May 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28516460/taxane-grafted-metal-oxide-nanoparticles-as-a-new-theranostic-tool-against-cancer-the-promising-example-of-docetaxel-functionalized-titanate-nanotubes-on-prostate-tumors
#8
Alexis Loiseau, Julien Boudon, Céline Mirjolet, Gilles Créhange, Nadine Millot
The combination of anticancer drugs and metal oxide nanoparticles is of great interest in cancer nanomedicine. Here, the development of a new nanohybrid, titanate nanotube-docetaxel (TiONts-DTX) is reported, the two parts of which are conjugated by covalent linkages. Unlike most nanoparticles currently being developed for biomedical purposes, TiONts present a needle-shaped morphology. The surface of TiONts is linked with 3-aminopropyl triethoxysilane and with a hetero-bifunctional polymer (polyethylene glycol) to create well-dispersed and biocompatible nanovectors...
May 18, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28513140/hybrid-prodrug-nanoparticles-with-tumor-penetration-and-programmed-drug-activation-for-enhanced-chemo-resistant-cancer-therapy
#9
Caiyan Zhao, Leihou Shao, Jianqing Lu, Xiongwei Deng, Yujia Tong, Yan Wu
Despite nanomedicine has shown great potential for reverse cancer cells resistance, the suboptimal transport across multiple biological obstacles seriously impedes its reaching targets at an efficacious level, which remains the challenging hurdle for clinical success in resistant cancer therapy. Here, a lipid-based hybrid nanoparticle was designed to efficiently deliver the therapeutics to resistant cells and treat resistant cancer in vivo. The hybrid nanoparticles (D-NPs/TET) are composed of a pH-responsive prodrug 1,2-distearoyl-snglycero-3-phosphoethanolamine (DSPE)-doxorubicin (DOX), a efflux inhibitor tetrandrine (TET) and a surfactant 1,2-distearoyl-snglycero-3-phosphoethanolamine-[methoxy (polyethylene glycol)-2000] (DSPE-mPEG2000), which hierarchically combatted the sequential physiological and pathological barriers of drug resistance, exhibited prolonged blood circulation, high tumor accumulation, and deep tumor parenchyma penetration...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28506745/applying-nanomedicine-in-maladaptive-inflammation-and-angiogenesis
#10
Amr Alaarg, Carlos Pérez-Medina, Josbert M Metselaar, Matthias Nahrendorf, Zahi A Fayad, Gert Storm, Willem J M Mulder
Inflammation and angiogenesis drive the development and progression of multiple devastating diseases such as atherosclerosis, cancer, rheumatoid arthritis, and inflammatory bowel disease. Though these diseases have very different phenotypic consequences, they possess several common pathophysiological features in which monocyte recruitment, macrophage polarization, and enhanced vascular permeability play critical roles. Thus, developing rational targeting strategies tailored to the different stages of the journey of monocytes, from bone marrow to local lesions, and their extravasation from the vasculature in diseased tissues will advance nanomedicine...
May 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28506743/peptide-modified-nanomedicines-for-targeting-cells-at-the-tumor-microenvironment
#11
Ayelet David
Since their initial discovery more than 30 years ago, tumor-homing peptides have become an increasingly useful tool for targeted delivery of therapeutic and diagnostic agents into tumors. Today, it is well accepted that cells at tumor microenvironment (TME) contributes in many ways to cancer development and progression. Tumor-homing peptide are highly suitable ligands to actively target cells at the TME owing to their small size, low immunogenicity, stability, easy manufacturing and low cost. When conjugated to nanosized medicines (nanomedicines) these ligands can interact specifically with surface receptors expressed on cells in the heterogeneous TME, improve cellular uptake of nanomedicines by target cells, and potentially impair tumor growth and progression...
May 12, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28504884/d-%C3%AE-tocopheryl-succinate-phosphatidyl-ethanolamine-conjugated-amphiphilic-polymer-based-nanomicellar-system-for-the-efficient-delivery-of-curcumin-and-to-overcome-multiple-drug-resistance-in-cancer
#12
Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Vladimir P Torchilin, Swati Biswas
Nanomedicines have emerged as a promising treatment strategy for cancer. Multiple drug resistance due to overexpression of various drug efflux transporters and upregulation of apoptotic inhibitory pathways in cancer cells are major barriers that limit the success of chemotherapy. Here, we developed a d-α-tocopherol (α-TOS)/lipid-based copolymeric nanomicellar system (VPM) by conjugating phosphatidyl ethanolamine (PE) and α-TOS with poly(ethylene glycol) (PEG) via an amino acid linkage. The synthesized polymers were characterized by Fourier transform IR, gas-phase chromatography, and (1)H and (13)C NMR spectroscopy...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28503952/hyaluronic-acid-polyethylene-glycol-nanoparticles-for-controlled-delivery-of-mitoxantrone
#13
Azam Sargazi, Naeem Kamali, Fereshteh Shiri, Mostafa Heidari Majd
Hyaluronic acid (HA) has inherent ability to target the CD44 receptors and internalize into tumour cells via receptor-mediated endocytosis. Therefore, conjugation of this natural linear polysaccharide to polymeric NPs or micelles, as one of the most promising approaches, could be useful for future clinical applications such as drug delivery. Accordingly, we report on the synthesis of mitoxantrone (MTX)-conjugated polymeric nanoparticles (NPs) composed of polyethylene glycol-HA (PEG-HA) for MTX delivery toward special tumour cells...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28483691/3d-tumor-microtissues-as-an-in-vitro-testing-platform-for-microenvironmentally-triggered-drug-delivery-systems
#14
Virginia Brancato, Filomena Gioiella, Martina Profeta, Giorgia Imparato, Daniela Guarnieri, Francesco Urciuolo, Pietro Melone, Paolo A Netti
Therapeutic approaches based on nanomedicine have garnered great attention in cancer research. In vitro biological models that better mimic in vivo conditions are crucial tools to more accurately predict their therapeutic efficacy in vivo. In this work, a new 3D breast cancer microtissue has been developed to recapitulate the complexity of the tumor microenvironment and to test its efficacy as screening platform for drug delivery systems. The proposed 3D cancer model presents human breast adenocarcinoma cells and cancer-associated fibroblasts embedded in their own ECM, thus showing several features of an in vivo tumor, such as overexpression of metallo-proteinases (MMPs)...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28477000/ros-generation-and-dna-damage-with-photo-inactivation-mediated-by-silver-nanoparticles-in-lung-cancer-cell-line
#15
Ahmed El-Hussein, Michael R Hamblin
Lung cancer is considered one of the major health problems worldwide and the burden is even heavier in Africa. Nanomedicine is considered one of the most promising medical research applications nowadays. This is due to the unique physical and chemical properties of materials at the nanoscale. Silver nanoparticles have been extensively studied recently in many biomedical applications especially in cancer treatment, since they possess multifunctional effects that make these nanostructures ideal candidates for biomedical applications...
March 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28471401/nanomedicine-strategies-to-target-tumor-associated-macrophages
#16
REVIEW
Karin Binnemars-Postma, Gert Storm, Jai Prakash
In recent years, the influence of the tumor microenvironment (TME) on cancer progression has been better understood. Macrophages, one of the most important cell types in the TME, exist in different subtypes, each of which has a different function. While classically activated M1 macrophages are involved in inflammatory and malignant processes, activated M2 macrophages are more involved in the wound-healing processes occurring in tumors. Tumor-associated macrophages (TAM) display M2 macrophage characteristics and support tumor growth and metastasis by matrix remodeling, neo-angiogenesis, and suppressing local immunity...
May 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28471200/-fullerene-doxorubicin-nanotransporter-for-target-interaction-with-mutated-gene-brca2
#17
S Skaličková, M Löfelmann, M Gargulák, M Dočekalová, B Ruttkay-Nedecký, P Suchý, M Kepinská, R Kizek
BACKGROUND: Malignant breast tumors are in developed countries, the most common cancer affecting mainly women. It is estimated that approximately 5-10% of breast cancers are conditioned by genetic family burdens, caused by mutation in the BRCA2 gene. In the course of the treatment doxorubicin is frequently used therapeutics. Despite its therapeutic efficacy, however, it shows high cardiotoxicity. Possibility to increase the therapeutic window, represent nanotransporters. Fullerenes are nanoparticles composed of carbon atoms whose physical-chemical properties indicate high stability...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28471199/-zinc-modified-nanotransporter-for-target-drug-therapy-of-breast-cancer
#18
S Skaličková, M Gargulák, M Löffelmann, B Ruttkay-Nedecký, M Kepinská, T Parák, R Kizek
BACKGROUND: In the centre of nanomedical interest stands the nanotechnological modification of anthracycline antibiotics, which are often used in antitumor treatment of hematological malignancies and solid tumors. Chitosan nanoparticles are gaining more attention in the field of targeted transport of drugs because of their stability, low toxicity and simple preparation. The main objective of the project, was the design of chitosan nanotransporter of anthracycline antibiotics with zinc modified surface, for a specific interaction with metallothionein...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28464449/a-smart-nano-prodrug-platform-with-reactive-drug-loading-superb-stability-and-fast-responsive-drug-release-for-targeted-cancer-therapy
#19
Hao Meng, Yan Zou, Ping Zhong, Fenghua Meng, Jian Zhang, Ru Cheng, Zhiyuan Zhong
Nano-prodrugs usually involve a multistep synthesis which largely compromises their benefits. Here, a smart nano-prodrug platform with reactive drug loading, superb stability, and triggered drug release is reported for targeted melanoma therapy. cRGD-decorated polymersomal mertansine prodrug (cRGD-PS-DM1) is readily fabricated from cRGD-functionalized poly(ethylene glycol)-b-poly(trimethylene carbonate-co-dithiolane trimethylene carbonate) with simultaneous loading of mertansine (DM1) via thiol-disulfide exchange reaction and disulfide cross-linking of polymersomal membrane...
May 2, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28461100/reinforcing-nanomedicine-using-graphene-family-nanomaterials
#20
REVIEW
Jumana Abdul Jaleel, S Sruthi, K Pramod
Graphene is an allotrope of carbon which consists of single layered sp(2) hybridized carbon arranged in honey comb lattice. The fascinating properties such as ultrahigh surface area, high electrical and thermal conductivity and optical property made graphene a major point of research interest. Apart from their application in the field such as nanoelectronics, energy storage, engineering of nanocomposite materials, transistors, sensors, diodes, catalysis; they are also investigated in the field of nanomedicine...
April 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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