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cancer nanomedicine

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https://www.readbyqxmd.com/read/28643452/emerging-nanotechnology-and-advanced-materials-for-cancer-radiation-therapy
#1
REVIEW
Guosheng Song, Liang Cheng, Yu Chao, Kai Yang, Zhuang Liu
Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages...
June 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28642073/synthesis-of-biogenic-ag-pd-core-shell-nanoparticles-having-anti-cancer-anti-microbial-functions
#2
Wafa I Abdel-Fattah, M M Eid, Sh I Abd El-Moez, E Mohamed, Ghareib W Ali
Biogenic Ag@Pd core-shell nanoparticles were greenly synthesized within two plant extracts aiming at enhanced anticancer/bactericidal functions. These functions were verified for the two Pd@Ag biogenic core-shell nanoparticles (BCSnp) with constant Pd to several Ag contents. BCSnp were synthesized within two extracts of Almond nuts and Black Berry fruits, four samples each, through simple, low cost and echo friendly microwave route. The BCSnp Surface Plasmon Resonance (SPR) was detected via UV/visible spectrophotometer...
June 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/28638474/self-assembly-of-gold-nanoparticles-shows-microenvironment-mediated-dynamic-switching-and-enhanced-brain-tumor-targeting
#3
Qishuai Feng, Yajing Shen, Yingjie Fu, Megan E Muroski, Peng Zhang, Qiaoyue Wang, Chang Xu, Maciej S Lesniak, Gang Li, Yu Cheng
Inorganic nanoparticles with unique physical properties have been explored as nanomedicines for brain tumor treatment. However, the clinical applications of the inorganic formulations are often hindered by the biological barriers and failure to be bioeliminated. The size of the nanoparticle is an essential design parameter which plays a significant role to affect the tumor targeting and biodistribution. Here, we report a feasible approach for the assembly of gold nanoparticles into ~80 nm nanospheres as a drug delivery platform for enhanced retention in brain tumors with the ability to be dynamically switched into the single formulation for excretion...
2017: Theranostics
https://www.readbyqxmd.com/read/28636308/redox-sensitive-nanoscale-coordination-polymers-for-drug-delivery-and-cancer-theranostics
#4
Jiayue Zhao, Yu Yang, Xiao Han, Chao Liang, Jingjing Liu, Xuejiao Song, Zili Ge, Zhuang Liu
Nanoscale coordination polymers (NCPs) with inherent biodegradability, chemical diversities, and porous structures, are a promising class of nanomaterials in the nanomedicine field. Herein, a unique type of redox sensitive NCPs is constructed with manganese ions (Mn2+) and dithiodiglycolic acid as the disulfide (SS) containing organic bridging ligand. The obtained Mn-SS NCPs with mesoporous structure could be efficiently loaded with doxorubicin (DOX), a chemotherapeutics. The yielded Mn-SS/DOX nanoparticles are coated with a layer of polydopamine (PDA) and then modified by polyethylene glycol (PEG)...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28635544/heparin-new-life-for-an-old-drug
#5
Carlos Raúl Aláez-Versón, Elena Lantero, Xavier Fernàndez-Busquets
Heparin is one of the oldest drugs, which nevertheless remains in widespread clinical use as an inhibitor of blood coagulation. The history of its identification a century ago unfolded amid one of the most fascinating scientific controversies turning around the distribution of credit for its discovery. The composition, purification and structure-function relationship of this naturally occurring glycosaminoglycan regarding its classical role as anticoagulant will be dealt with before proceeding to discuss its therapeutic potential in, among other, inflammatory and infectious disease, cancer treatment, cystic fibrosis and Alzheimer's disease...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28629803/development-of-mpc-dpa-polymeric-nanoparticle-systems-for-inhalation-drug-delivery-applications
#6
Abdul Khaliq Elzhry Elyafi, Guy Standen, Steven T Meikle, Andrew L Lewis, Jonathan P Salvage
Inhalation of nanoparticles for pulmonary drug delivery offers the potential to harness nanomedicine formulations of emerging therapeutics, such as curcumin, for treatment of lung cancer. Biocompatible nanoparticles composed of poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (MPC-DPA) have been shown to be suitable nanocarriers for drugs, whilst N-trimethyl chitosan chloride (TMC) coating of nanoparticles has been reported to further enhance their cellular delivery efficacy; the combination of the two has not been previously investigated...
June 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28626793/acidic-ph-targeted-chitosan-capped-mesoporous-silica-coated-gold-nanorods-facilitate-detection-of-pancreatic-tumors-via-multispectral-optoacoustic-tomography
#7
Matthew R Zeiderman, Desiree E Morgan, John D Christein, William E Grizzle, Kelly M McMasters, Lacey R McNally
We present a cancer nanomedicine based on acidic pH targeted gold nanorods designed for multispectral optoacoustic tomography (MSOT). We have designed gold nanorods coated with mesoporous silica and subsequently capped with chitosan (CMGs). We have conjugated pH-sensitive variant 7 pHLIP peptide to the CMGs (V7-CMG) to provide targeting specificity to the acidic tumor microenvironment. In vitro, treatment of S2VP10 and MiaPaca2 cells with V7-CMG containing gemcitabine resulted in significantly greater cytotoxicity with 97% and 96...
July 11, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28625673/exploiting-passive-nanomedicine-accumulation-at-sites-of-enhanced-vascular-permeability-for-non-cancerous-applications
#8
REVIEW
Mikhail Durymanov, Tatiana Kamaletdinova, Sarah E Lehmann, Joshua Reineke
Over the past few decades, enhanced permeability of tumor vasculature was actively exploited for targeted delivery of anticancer nanomedicines resulting in numerous pharmaceutical products. Formation of new immature and leaky vessels along with inflammatory remodeling of existing vessels accompany development of numerous diseases beyond cancer and present an opportunity for passive accumulation of intravenously administered nanomedicines in many pathological tissues. To date, applications of non-cancerous enhanced permeation have been relatively unexploited as target tissues and may create new therapy and prevention technologies for many disorders...
June 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28624137/effect-of-tlr-ligands-co-encapsulated-with-multiepitopic-antigen-in-nanoliposomes-targeted-to-human-dcs-via-fc-receptor-for-cancer-vaccines
#9
Felix Rueda, Christina Eich, Begoña Cordobilla, Pere Domingo, Gerardo Acosta, Fernando Albericio, Luis J Cruz, Joan C Domingo
Nanoliposomes (NLs) hold promise as new highly specific nanomedicine for anti-tumor vaccines, since they could be targeted to specific receptors on dendritic cell (DC) to induce maturation and activation and increase the anti-tumor immune response. Here we studied a NLs formulation targeted or not to FcR (the receptor for the IgG Fc fragment) for the treatment of androgen-responsive prostate cancer. Luteinizing-hormone-releasing hormone (LHRH) peptide (B- and T-cell epitopes), in tandem with a tetanus toxoid T-helper epitope (830-844 region) and several TLR (Toll-Like Receptor) ligands as adjuvants were co-encapsulated...
June 10, 2017: Immunobiology
https://www.readbyqxmd.com/read/28621571/targeted-nanotechnologies-for-cancer-intervention-a-patent-review-2010-2016
#10
Priyamvada Pradeep, Pradeep Kumar, Yahya E Choonara, Viness Pillay
In recent years, several active targeting nanostrategies have been patented for application in cancer theranostics. The versatility of nanostructures in terms of composition, manufacturability, functionalization, and matrix formation make them ideal for carrying large dose of bioactive contents, high density of targeting ligands on their surface, efficient delivery to the site of interest, and capable of forming multicomponent platforms. Areas covered: The patents were classified into polymeric and non-polymeric nanostructures and their applicability in addressing the targeting paradigm related to cancer intervention was explored...
June 22, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28616966/magnetic-resonance-imaging-guided-multi-drug-chemotherapy-and-photothermal-synergistic-therapy-with-ph-and-nir-stimulation-release
#11
Jichun Yang, Yang Chen, Yu-Hao Li, Xue-Bo Yin
The combination of multi-drug chemotherapy and photothermal therapy (PTT) enhances cancer therapeutic efficacy. Herein, we develop a simple and smart pH/NIR dual-stimulus-responsive degradable mesoporous CoFe2O4@PDA@ZIF-8 sandwich nanocomposite. Mesoporous CoFe2O4 core acts as T2-weighted magnetic resonance (MR) imaging probe, PTT agent, and loading platform of hydrophilic doxorubicin (DOX). A polydopamine (PDA) layer is used to avoid the premature leakage of DOX before arriving at tumor site, enhance PTT efficiency, and facilitate the integration of ZIF-8 (a kind of metal-organic frameworks)...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28615943/the-use-of-functional-epirubicin-liposomes-to-induce-programmed-death-in-refractory-breast-cancer
#12
Lei Liu, Li-Min Mu, Yan Yan, Jia-Shuan Wu, Ying-Jie Hu, Ying-Zi Bu, Jing-Ying Zhang, Rui Liu, Xue-Qi Li, Wan-Liang Lu
Currently, chemotherapy is less efficient in controlling the continued development of breast cancer because it cannot eliminate extrinsic and intrinsic refractory cancers. In this study, mitochondria were modified by functional epirubicin liposomes to eliminate refractory cancers through initiation of an apoptosis cascade. The efficacy and mechanism of epirubicin liposomes were investigated on human breast cancer cells in vitro and in vivo using flow cytometry, confocal microscopy, high-content screening system, in vivo imaging system, and tumor inhibition in mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28606739/covalent-nanodelivery-systems-for-selective-imaging-and-treatment-of-brain-tumors
#13
Julia Y Ljubimova, Tao Sun, Leila Mashouf, Alexander V Ljubimov, Liron L Israel, Vladimir A Ljubimov, Vida Falahatian, Eggehard Holler
Nanomedicine is a rapidly evolving form of therapy that holds a great promise in superior drug delivery efficiency and therapeutic efficacy than conventional cancer treatment. In this review, we attempt to cover the benefits and the limitations of current nanomedicines with special attention to covalent nanoconjugates for imaging and drug delivery in brain. The improvement in brain tumor treatment remains dismal despite decades of efforts in drug development and patient care. One of the major obstacles in brain cancer treatment is the poor drug delivery efficiency owing to the unique blood-brain-barrier (BBB) in the CNS...
June 9, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28600977/targeting-epithelial-mesenchymal-transition-metal-organic-network-nano-complexes-for-preventing-tumor-metastasis
#14
Jin-Xuan Fan, Di-Wei Zheng, Lei Rong, Jing-Yi Zhu, Sheng Hong, Cao Li, Zu-Shun Xu, Si-Xue Cheng, Xian-Zheng Zhang
Tumor metastasis is the leading cause of death in cancer patients, and epithelial-mesenchymal transition (EMT) is an essential step in tumor metastasis. Unfortunately, during the chemotherapy, EMT could be induced under the selective pressure of clinical cytotoxic drugs. Here, to solve this problem, we have synthesized multi-functional epigallocatechin gallate/iron nano-complexes (EIN) as a versatile coating material to improve conventional therapies. In vitro studies showed that this strategy could eliminate EMT-type cancer cells...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28593948/conditional-internalization-of-pegylated-nanomedicines-by-peg-engagers-for-triple-negative-breast-cancer-therapy
#15
Yu-Cheng Su, Pierre-Alain Burnouf, Kuo-Hsiang Chuang, Bing-Mae Chen, Tian-Lu Cheng, Steve R Roffler
Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal growth factor receptor (EGFR) has emerged as a promising target for TNBC therapy because it is overexpressed in about 50% of TNBC patients. Here we describe a PEG engager that simultaneously binds polyethylene glycol and EGFR to deliver PEGylated nanomedicines to EGFR(+) TNBC. The PEG engager displays conditional internalization by remaining on the surface of TNBC cells until contact with PEGylated nanocarriers triggers rapid engulfment of nanocargos...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28583444/nanomedicine-for-prostate-cancer-using-nanoemulsion-a-review
#16
REVIEW
Aravindsiva Sasikumar, Kaladhar Kamalasanan
Prostate cancer (PCa) is a worldwide issue, with burgeoning rise in prevalence, morbidity and mortality. Targeted drug delivery, a long sort solution in this regard using controlled release (CR) - nanocarriers, is still a challenge. There is an emerging criticism that, the challenges are due to less appreciation for the biological barriers and lack of corresponding newer technologies. Over the years, more understanding about the biological barriers has come with the progress in characterization techniques. Correspondingly, there is a change in opinion about approaches in clinical trial that; focus of the end point need to be shifted towards disease stabilization for these explorative technologies...
June 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28577732/-prospective-how-will-renal-prostatic-and-urothelial-tumours-be-treated-in-10%C3%A2-years
#17
REVIEW
Alain Toledano, Mayada Bourmech, Hanah Lamallem, Marc Bollet, Olivier Bauduceau, Pascal Pujol, Patrick Bloch, David Khayat
Forward thinking does not seek to predict the future, to unveil it as if it were already in existence, rather, its aim is to help us to construct it. Although today's epidemiological and therapeutic situations for urogenital tumours can evolve over the next 10 years, diagnostic and therapeutic methods, as well as the treatment and implementation of innovations, are already rapidly changing. Rather than reducing our prospective thinking to the therapeutic treatment of cancer only, we will aim at proposing a global sanitary vision that includes diagnosis, therapies, prevention, routine utilisation of technomedicine, genomics and even nanomedicine...
April 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28574639/dna-origami-applications-in-cancer-therapy
#18
REVIEW
Anuttara Udomprasert, Thaned Kangsamaksin
Due to the complexity and heterogeneity of cancer, the development of cancer diagnosis and therapy is still progressing, and a complete understanding of cancer biology still remain elusive. Recently, cancer nanomedicine has gained much interest as promising diagnostic and therapeutic strategies as a wide range of nanomaterials possess unique physical properties that can render drug delivery systems more effective and safer. Also, targeted drug delivery and precision medicine have now become a new paradigm in cancer therapy...
June 2, 2017: Cancer Science
https://www.readbyqxmd.com/read/28570787/bridging-the-knowledge-of-different-worlds-to-understand-the-big-picture-of-cancer-nanomedicines
#19
REVIEW
Vimalkumar Balasubramanian, Zehua Liu, Jouni Hirvonen, Hélder A Santos
Explosive growth of nanomedicines continues to significantly impact the therapeutic strategies for effective cancer treatment. Despite the significant progress in the development of advanced nanomedicines, successful clinical translation remains challenging. As cancer nanomedicine is a multidisciplinary field, the fundamental problem is that the knowledge gaps stem from different vantage points in the understanding of cancer nanomedicines. The complexities and heterogenecity of both nanomedicines and cancer are further demanding the integration of highly diverse expertise to develop clinically translatable cancer nanomedicines...
June 1, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28553112/ionp-doped-nanoparticles-for-highly-effective-nir-controlled-drug-release-and-combination-tumor-therapy
#20
Xudong Fu, Xinjun Wang, Shaolong Zhou, Yanyan Zhang
Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled "off-on" DDS with magnetic resonance imaging and magnetic targeting properties was developed using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle)...
2017: International Journal of Nanomedicine
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