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https://www.readbyqxmd.com/read/28447447/nuclear-targeting-gold-nanorods-for-extremely-low-nir-activated-photothermal-therapy
#1
Limin Pan, Jianan Liu, Jianlin Shi
Photo-related nanomedicine is of particular interest as an emerging paradigm toward precise cancer therapy, as demonstrated by the recent developments of photothermal therapy (PTT), an emerging technique employing light converting agents to burn cancerous cells by over-dosed optical energy-converted heat. However, most of the laser irradiations needed for effective PTT significantly exceed the maximal permissible power density in human skin, which is likely to damage surrounding normal tissues. Herein, we report a strategy of intranuclear PTT of cancer enabled by nuclear-targeted delivery of gold nanorods of ~ 10...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28444967/co-delivery-of-microrna-21-antisense-oligonucleotides-and-gemcitabine-using-nanomedicine-for-pancreatic-cancer-therapy
#2
Yaqing Li, Yinting Chen, Jiajia Li, Zuoquan Zhang, Chumei Huang, Guoda Lian, Kege Yang, Shaojie Chen, Ying Lin, Lingyun Wang, Kaihong Huang, Linjuan Zeng
Tumor metastasis occurs naturally in pancreatic cancer, and the efficacy of chemotherapy is usually poor. Precision medicine, combining down-regulation of target genes with chemotherapy drugs, is expected to improve the therapeutic effects. Therefore, we developed a combined therapy of microRNA-21 antisense oligonucleotides (ASO-miR-21) and Gemcitabine (Gem) using a targeted co-delivery nanoparticle (NP) carrier and investigated the synergistic inhibitory effects on pancreatic cancer cells metastasis and growth...
April 26, 2017: Cancer Science
https://www.readbyqxmd.com/read/28442415/retro-inverso-d-peptide-modified-ha-rhb-pdna-core-shell-ternary-nanoparticles-for-the-dual-targeted-delivery-of-short-hairpin-rna-encoding-plasmids
#3
Jijin Gu, Xinyi Chen, Xiaoling Fang, Xianyi Sha
The active targeting of gene carriers is a powerful strategy for improving tumour-specific delivery and therapy. Although numerous L-peptide ligands play significant roles in the active targeting of nanomedicine, retro-inverso D-peptides have been explored as targeting ligands due to their superior stability and bioactivity in vivo. In this study, retro-inverso D-peptide (RIF7)-modified hyaluronic acid (HA)/bioreducible hyperbranched poly(amido amine) (RHB)/plasmid DNA (pDNA) ternary nanoparticles were successfully developed using the layer-by-layer method for the CD44-positive tumour-specific delivery of short hairpin RNA-encoding pDNA through the synergistic reaction of the Anxa1 (tumour vasculature) and CD44 (tumour cell-surface) receptors, which mediated the dual targeting...
April 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28441355/-188-re-liposome-can-induce-mitochondrial-autophagy-and-reverse-drug-resistance-for-ovarian-cancer-from-bench-evidence-to-preliminary-clinical-proof-of-concept
#4
Chia-Ming Chang, Keng-Li Lan, Wen-Sheng Huang, Yi-Jang Lee, Te-Wei Lee, Chih-Hsien Chang, Chi-Mu Chuang
Despite standard treatment, about 70% of ovarian cancer will recur. Cancer stem cells (CSCs) have been implicated in the drug-resistance mechanism. Several drug resistance mechanisms have been proposed, and among these, autophagy plays a crucial role for the maintenance and tumorigenicity of CSCs. Compared to their differentiated counterparts, CSCs have been demonstrated to display a significantly higher level of autophagy flux. Moreover, mitophagy, a specific type of autophagy that selectively degrades excessive or damaged mitochondria, is shown to contribute to cancer progression and recurrence in several types of tumors...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28437627/tumor-acidity-activatable-tat-targeted-nanomedicine-for-enlarged-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#5
Meng Gao, Feng Fan, Dongdong Li, Yue Yu, Kuirong Mao, Tianmeng Sun, Haisheng Qian, Wei Tao, Xianzhu Yang
Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28436718/design-of-a-novel-curcumin-soybean-phosphatidylcholine-complex-based-targeted-drug-delivery-systems
#6
Jiajiang Xie, Yanxiu Li, Liang Song, Zhou Pan, Shefang Ye, Zhenqing Hou
Recently, the global trend in the field of nanomedicine has been toward the design of combination of nature active constituents and phospholipid (PC) to form a therapeutic drug-phospholipid complex. As a particular amphiphilic molecular complex, it can be a unique bridge of traditional dosage-form and novel drug delivery system. In thisarticle, on the basis of drug-phospholipid complex technique and self-assembly technique, we chose a pharmacologically safe and low toxic drug curcumin (CUR) to increase drug-loading ability, achieve controlled/sustained drug release and improve anticancer activity...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28435462/a-programmed-nanoparticle-with-self-adapting-for-accurate-cancer-cell-eradication-and-therapeutic-self-reporting
#7
Yingping Luo, Liwei Huang, Ye Yang, Xianfei Zhuang, Siyao Hu, Huangxian Ju, Bo-Yang Yu, Jiangwei Tian
To achieve the best therapeutic efficacy and good prognosis, the drugs necessitate tailored profiles of excellent spatiotemporal control and therapeutic monitoring. Here we introduce a programmed theranostic nanoparticle with self-adapting properties for tumor-specific systemic treatment, including stealthy surface to prolong circulation time in blood, surface charge-reversion for tumor targeting, receptor-mediated internalization to increase intracellular accumulation, "proton sponge effect" for controllable drug release and escape from endo/lysosome...
2017: Theranostics
https://www.readbyqxmd.com/read/28435264/efficient-co-delivery-of-immiscible-hydrophilic-hydrophobic-chemotherapeutics-by-lipid-emulsions-for-improved-treatment-of-cancer
#8
Bo Zhang, Yunmei Song, Tianqi Wang, Shaomei Yang, Jing Zhang, Yongjun Liu, Na Zhang, Sanjay Garg
Combinational nanomedicine is becoming a topic of much interest in cancer therapy, although its translation into the clinic remains extremely challenging. One of the main obstacles lies in the difficulty to efficiently co-deliver immiscible hydrophilic/hydrophobic drugs into tumor sites. The aim of this study was to develop co-loaded lipid emulsions (LEs) to co-deliver immiscible hydrophilic/hydrophobic drugs to improve cancer therapy and to explore the co-delivery abilities between co-loaded LEs and mixture formulation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28435061/nanomedicine-mediated-drug-targeting-of-cancer-stem-cells
#9
REVIEW
Deepika Singh, Aliva Prity Minz, Sanjeeb Kumar Sahoo
Tumors are heterogeneous and contain a small population of cells that has a crucial role in tumor progression, metastasis, drug resistance, and relapse as a result of their self-renewal, proliferation, and differentiation properties. These cells are known as cancer stem cells (CSCs) and accumulating evidence suggests that they show significant resistance to conventional chemotherapy. Thus, various antitumor strategies have been developed to eliminate therapeutic-resistant CSCs by targeting the molecular differences between CSCs and bulk cancer cells...
April 20, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28423731/a-multifunctional-lipid-nanoparticle-for-co-delivery-of-paclitaxel-and-curcumin-for-targeted-delivery-and-enhanced-cytotoxicity-in-multidrug-resistant-breast-cancer-cells
#10
Jong-Suep Baek, Cheong-Weon Cho
The objective of the work was to develop a multifunctional nanomedicine based on a folate-conjugated lipid nanoparticles loaded with paclitaxel and curcumin. The novel system combines therapeutic advantageous of efficient targeted delivery via folate and timed-release of curcumin and paclitaxel via 2-hydroxypropyl-ß-cyclodextrin, thereby overcoming multidrug resistance in breast cancer cells (MCF-7/ADR). The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel...
March 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422481/gold-nanoparticles-induced-endothelial-leakiness-depends-on-particle-size-and-endothelial-cell-origin
#11
Magdiel I Setyawati, Chor Yong Tay, Boon Huat Bay, David T Leong
The endothelium presents a formidable barrier for cancer nanomedicine, as the intravenously introduced nanomedicine needs to leave the blood vessel at the tumor site. Endothelial permeability and retention effect (EPR) is not dependable since it is derived from tumors. Certain nanoparticles with specific characteristics are able to induce micrometer sized gaps between endothelial cells. This effect is called "nanoparticle induced endothelial leakiness" (NanoEL). NanoEL therefore allows the nanotechnology to control access to the tumor even in the absence of any EPR effect...
April 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28418176/panitumumab-conjugated-pt-drug-nanomedicine-for-enhanced-efficacy-of-combination-targeted-chemotherapy-against-colorectal-cancer
#12
Ming-Hsien Tsai, Chao-Hsuan Pan, Cheng-Liang Peng, Ming-Jium Shieh
Targeted combination chemotherapy (TCT) has recently been used to increase the induction of tumor cell death. In particular, the combination of Panitumumab and the platinum (Pt)-derived chemotherapeutic drug Oxaliplatin is clinically effective against KRAS and BRAF wild-type colorectal cancer (CRC) cells that overexpress epidermal growth factor receptors, and significantly greater efficacy is observed than with either drug alone. However, low accumulation of Pt drug in tumor sites prevents achievement of ideal efficacy...
April 18, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28416486/a-squalene-based-nanomedicine-for-oral-treatment-of-colon-cancer
#13
Larissa Kotelevets, Eric Chastre, Joachim Caron, Julie Mougin, Gerard Bastian, Alain Pineau, Francine Walker, Therese Lehy, Didier Desmaele, Patrick Couvreur
Nanotechnology offers many possibilities to improve drug treatments, including with regard to drug pharmacology. The current study reports a simple approach to improve cisplatin efficacy in the treatment of colon cancer through the creation of orally administered squalenoylated nanoparticles loaded with cisplatin (SQ-CDDP NP). Cytotoxic effects of SQ-CDDP NP were assessed in human colonic cells and in mouse models of intestinal cancer. In cell culture, SQ-CDDP NP exhibited at least 10-fold greater cytotoxic potency compared to uncomplexed cisplatin, reflecting an enhancement in intracellular accumulation and DNA platination...
April 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28415433/multifunctional-nanospheres-for-co-delivery-of-methotrexate-and-mild-hyperthermia-to-colon-cancer-cells
#14
Sofia A Costa Lima, André Gaspar, Salette Reis, Luísa Durães
A multifunctional nanomedicine platform was designed and evaluated for efficient colon cancer therapy by a combinatorial therapeutic approach based on a chemotherapeutic drug and mild hyperthermia. Advantage was taken from the dual role of methotrexate (MTX), as folate receptor-targeting, overexpressed in tumor cells, and as anticancer drug. Incorporation of superparamagnetic iron oxide nanoparticles (SPIONs) allows to heat cancer cells externally through an alternating magnetic field. The developed nanocarrier was based on polyethylene glycol-polylactic acid (PEG-PLA) nanospheres to improve biocompatibility, enhancing their targeting by prolonging blood circulation time...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408882/targeted-nanotechnology-in-glioblastoma-multiforme
#15
REVIEW
Talita Glaser, Inbo Han, Liquan Wu, Xiang Zeng
Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors characterized by a poor prognosis and high rates of recurrence. Current treatment strategies are based on open surgery, chemotherapy (temozolomide) and radiotherapy. However, none of these treatments, alone or in combination, are considered effective in managing this devastating disease, resulting in a median survival time of less than 15 months. The efficiency of chemotherapy is mainly compromised by the blood-brain barrier (BBB) that selectively inhibits drugs from infiltrating into the tumor mass...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28408824/cuprous-oxide-nanoparticles-inhibit-prostate-cancer-by-attenuating-the-stemness-of-cancer-cells-via-inhibition-of-the-wnt-signaling-pathway
#16
Ye Wang, Qi-Wei Yang, Qing Yang, Tie Zhou, Min-Feng Shi, Chen-Xia Sun, Xiu-Xia Gao, Yan-Qiong Cheng, Xin-Gang Cui, Ying-Hao Sun
Disordered copper metabolism plays a critical role in the development of various cancers. As a nanomedicine containing copper, cuprous oxide nanoparticles (CONPs) exert ideal antitumor pharmacological effects in vitro and in vivo. Prostate cancer is a frequently diagnosed male malignancy prone to relapse, and castration resistance is the main reason for endocrine therapy failure. However, whether CONPs have the potential to treat castration-resistant prostate cancer is still unknown. Here, using the castration-resistant PC-3 human prostate cancer cell line as a model, we report that CONPs can selectively induce apoptosis and inhibit the proliferation of cancer cells in vitro and in vivo without affecting normal prostate epithelial cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28406072/harmful-at-non-cytotoxic-concentrations-sio2-spions-affect-surfactant-metabolism-and-lamellar-body-biogenesis-in-a549-human-alveolar-epithelial-cells
#17
Veno Kononenko, Andreja Erman, Toni Petan, Igor Križaj, Slavko Kralj, Darko Makovec, Damjana Drobne
The pulmonary delivery of nanoparticles (NPs) is a promising approach in nanomedicine. For the efficient and safe use of inhalable NPs, understanding of NP interference with lung surfactant metabolism is needed. Lung surfactant is predominantly a phospholipid substance, synthesized in alveolar type II cells (ATII), where it is packed in special organelles, lamellar bodies (LBs). In vitro and in vivo studies have reported NPs impact on surfactant homeostasis, but this phenomenon has not yet been sufficiently examined...
April 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28393881/tranilast-induced-stress-alleviation-in-solid-tumors-improves-the-efficacy-of-chemo-and-nanotherapeutics-in-a-size-independent-manner
#18
Panagiotis Papageorgis, Christiana Polydorou, Fotios Mpekris, Chrysovalantis Voutouri, Eliana Agathokleous, Constantina P Kapnissi-Christodoulou, Triantafyllos Stylianopoulos
Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and nanotherapies. Stress alleviation treatment has been recently proposed to reduce mechanical stresses in order to decompress tumor vessels and improve perfusion and chemotherapy. However, it remains unclear if it improves the efficacy of nanomedicines, which present numerous advantages over traditional chemotherapeutic drugs...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393695/metallic-nanoclusters-for-cancer-imaging-and-therapy
#19
Qing Zhang, Mingying Yang, Ye Zhu, Chuanbin Mao
Different from traditional nanoparticles, inorganic metallic nanoclusters show a multitude of novel optical and electronic properties because of their ultra-small size. They display unique tunable luminescence and excellent biocompatibility. They are also easy to be conjugated and thus can be facilely functionalized to present targeting ligands in cancer imaging and therapy. These properties are highly desired in the development of cancer nanotheranostics. Moreover, NCs can be removed from the body by the mechanism of renal clearance after performing their intended tasks whereas traditional nanoparticles usually trigger severe side effects because of their aggregation in the liver and spleen...
March 31, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28393692/nanostructures-for-ph-sensitive-drug-delivery-and-magnetic-resonance-contrast-enhancement-systems
#20
Xiao Sun, Guilong Zhang, Zhengyan Wu
According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc...
April 6, 2017: Current Medicinal Chemistry
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