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https://www.readbyqxmd.com/read/27920893/antibody-drug-conjugates-and-other-nanomedicines-the-frontier-of-gynaecological-cancer-treatment
#1
REVIEW
David Howard, Jetzabel Garcia-Parra, Gareth D Healey, Cynthia Amakiri, Lavinia Margarit, Lewis W Francis, Deyarina Gonzalez, R Steven Conlan
Gynaecological cancers: malignancies of the cervix, uterus, ovaries, vagina and vulva, are responsible for over 1.1 million new cancer cases and almost half a million deaths annually. Ovarian cancer in particular is difficult to treat due to often being diagnosed at a late stage, and the incidence of uterine and vulvar malignancies are both on the rise. The field of nanomedicine is beginning to introduce drugs into the clinic for oncological applications exemplified by the liposomal drugs, Doxil and Myocet, the nanoparticle, Abraxane and antibody-drug conjugates (ADCs), Kadcyla and Adcetris...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920520/ligand-based-targeted-therapy-a-novel-strategy-for-hepatocellular-carcinoma
#2
REVIEW
Min Li, Weiyue Zhang, Birong Wang, Yang Gao, Zifang Song, Qi Chang Zheng
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with high morbidity and mortality worldwide. Chemotherapy is recommended to patients with intermediate or advanced stage cancer. However, the conventional chemotherapy yields low desired response rates due to multidrug resistance, fast clearance rate, nonspecific delivery, severe side effects, low drug concentration in cancer cells, and so on. Nanoparticle-mediated targeted drug delivery system can surmount the aforementioned obstacles through enhanced permeability and retention effect and active targeting as a novel approach of therapeutics for HCC in recent years...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27916693/comparison-of-2-strategies-to-enhance-pyridoclax-solubility-nanoemulsion-delivery-system-versus-salt-synthesis
#3
A-C Groo, M De Pascale, A-S Voisin-Chiret, S Corvaisier, M Since, A Malzert-Fréon
Pyridoclax is an original oligopyridine lead, very promising in treatment of chemoresistant cancers. However, from solubility measurement and permeability evaluation, it appeared that this compound can be considered as a BCS II drug, with a poor water solubility. To overcome this unfavorable property, two strategies were proposed and compared: pyridoclax di-hydrochloride salt synthesis and formulation of pyridoclax-loaded nanoemulsions (PNEs) efficiently performed by transposing the spontaneous emulsification process previously developed by our team...
December 1, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27914571/evaluating-the-anticancer-activity-and-nanoparticulate-nature-of-homeopathic-preparations-of-terminalia-chebula
#4
Kirtee Wani, Nilesh Shah, Asmita Prabhune, Arun Jadhav, Prabhakar Ranjekar, Ruchika Kaul-Ghanekar
BACKGROUND: Breast cancer is the most common cancer diagnosed among women and is the second leading cause of cancer death. Homeopathic medicines are part of the alternative medicines that are given as a supportive therapy in breast cancer. The objective of this study was to investigate the anticancer activity of commercially available homeopathic preparations of Terminalia chebula (TC) and evaluate their nanoparticulate nature. METHODS: Mother tincture (MT) and other homeopathic preparations (3X, 6C and 30C) of TC were tested for their effect on the viability of breast cancer (MDAMB231 and MCF7) and non-cancerous (HEK 293) cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
November 2016: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/27912846/new-insights-and-evolving-role-of-pegylated-liposomal-doxorubicin-in-cancer-therapy
#5
REVIEW
Alberto A Gabizon, Yogita Patil, Ninh M La-Beck
We herein review various pharmacological and clinical aspects of pegylated liposomal doxorubicin (PLD), the first nanomedicine to be approved for cancer therapy, and discuss the gap between its potent antitumor activity in preclinical studies and its comparatively modest achievements in clinical studies and limited use in clinical practice. PLD is a complex formulation of doxorubicin based on pharmaceutical nanotechnology with unique pharmacokinetic and pharmacodynamic properties. Its long circulation time with stable retention of the payload and its accumulation in tumors with high vascular permeability both result in important advantages over conventional chemotherapy...
November 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27909463/synthetic-nanoparticles-for-delivery-of-radioisotopes-and-radiosensitizers-in-cancer-therapy
#6
REVIEW
Jun Zhao, Min Zhou, Chun Li
Radiotherapy has been, and will continue to be, a critical modality to treat cancer. Since the discovery of radiation-induced cytotoxicity in the late 19th century, both external and internal radiation sources have provided tremendous benefits to extend the life of cancer patients. Despite the dramatic improvement of radiation techniques, however, one challenge persists to limit the anti-tumor efficacy of radiotherapy, which is to maximize the deposited dose in tumor while sparing the rest of the healthy vital organs...
2016: Cancer Nanotechnology
https://www.readbyqxmd.com/read/27899033/novel-antibacterial-polymeric-nanocomposite-for-smart-co-delivery-of-anticancer-drugs
#7
Elham Zakerzadeh, Effat Alizadeh, Hossein Samadi Kafil, Azad Mohammad Hassanzadeh, Roya Salehi, Mehrdad Mahkam
Here a novel antibacterial nanocomposite was developed for combination cancer therapy. The synthesized nanocarrier was characterized by FTIR, (1)H NMR, thermogravimetric analysis (TGA), and FESEM-EDX. Its antibacterial activity was assessed by determining minimum inhibitory concentration (MIC) values. Doxorubicin (DOX) and methotrexate (MTX) conjugation with nanocarrier sustained the release of both drugs with apparent pH-triggered manner. Co-administration of DOX with MTX leads to an efficient anticancer performance to MCF7 cell lines verified by qRT-PCR and MTT assay tests...
November 29, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27897260/corrigendum-combinatorial-nanocarrier-based-drug-delivery-approach-for-amalgamation-of-anti-tumor-agents-in-breast-cancer-cells-an-improved-nanomedicine-strategy
#8
Chandran Murugan, Kathirvel Rayappan, Ramar Thangam, Ramasamy Bhanumathi, Krishnamurthy Shanthi, Raju Vivek, Ramasamy Thirumurugan, Atanu Bhattacharyya, Srinivasan Sivasubramanian, Palani Gunasekaran, Soundarapandian Kannan
No abstract text is available yet for this article.
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891093/targeting-strategies-for-renal-cell-carcinoma-from-renal-cancer-cells-to-renal-cancer-stem-cells
#9
REVIEW
Zhi-Xiang Yuan, Jingxin Mo, Guixian Zhao, Gang Shu, Hua-Lin Fu, Wei Zhao
Renal cell carcinoma (RCC) is a common form of urologic tumor that originates from the highly heterogeneous epithelium of renal tubules. Over the last decade, targeting therapies to renal cancer cells have transformed clinical care for RCC. Recently, it was proposed that renal cancer stem cells (CSCs) isolated from renal carcinomas were responsible for driving tumor growth and resistance to conventional chemotherapy and radiotherapy, according to the theory of CSCs; this has provided the rationale for therapies targeting this aggressive cell population...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27887958/bottom-up-synthesis-of-carbon-nanoparticles-with-higher-doxorubicin-efficacy
#10
Samer Bayda, Mohamad Hadla, Stefano Palazzolo, Vinit Kumar, Isabella Caligiuri, Emmanuele Ambrosi, Enrico Pontoglio, Marco Agostini, Tiziano Tuccinardi, Alvise Benedetti, Pietro Riello, Vincenzo Canzonieri, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio
Nanomedicine requires intelligent and non-toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects. Interest in carbon nanoparticles (CNPs) is increasing because they are considered green materials with tunable optical properties, overcoming the problem of toxicity associated with quantum dots or nanocrystals, and can be utilized as smart drug delivery systems. Using black tea as a raw material, we synthesized CNPs with a narrow size distribution, tunable optical properties covering visible to deep red absorption, non-toxicity and easy synthesis for large-scale production...
November 22, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27882622/black-phosphorus-nanosheet-based-drug-delivery-system-for-synergistic-photodynamic-photothermal-chemotherapy-of-cancer
#11
Wansong Chen, Jiang Ouyang, Hong Liu, Min Chen, Ke Zeng, Jianping Sheng, Zhenjun Liu, Yajing Han, Liqiang Wang, Juan Li, Liu Deng, You-Nian Liu, Shaojun Guo
A black phosphorus (BP)-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer is constructed. As a 2D nanosheet, BP shows super high drug loading capacity and pH-/photoresponsive drug release. The intrinsic photothermal and photodynamic effects of BP enhance the antitumor activities. The synergistic photodynamic/photothermal/chemotherapy makes BP-based drug delivery system a multifunctional nanomedicine platform.
November 24, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27879628/carbon-based-materials-for-photo-triggered-theranostic-applications
#12
REVIEW
Karunya Albert, Hsin-Yun Hsu
Carbon-based nanomaterials serve as a type of smart material for photo-triggered disease theranostics. The inherent physicochemical properties of these nanomaterials facilitate their use for less invasive treatments. This review summarizes the properties and applications of materials including fullerene, nanotubes, nanohorns, nanodots and nanographenes for photodynamic nanomedicine in cancer and antimicrobial therapies. Carbon nanomaterials themselves do not usually act as photodynamic therapy (PDT) agents owing to the high hydrophobicity, however, when the surface is passivated or functionalized, these materials become great vehicles for PDT...
November 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27871992/to-exploit-the-tumor-microenvironment-since-the-epr-effect-fails-in-the-clinic-what-is-the-future-of-nanomedicine
#13
REVIEW
F Danhier
Tumor targeting by nanomedicine-based therapeutics has emerged as a promising approach to overcome the lack of specificity of conventional chemotherapeutic agents and to provide clinicians the ability to overcome shortcomings of current cancer treatment. The major underlying mechanism of the design of nanomedicines was the Enhanced Permeability and Retention (EPR) effect, considered as the "royal gate" in the drug delivery field. However, after the publication of thousands of research papers, the verdict has been handed down: the EPR effect works in rodents but not in humans! Thus the basic rationale of the design and development of nanomedicines in cancer therapy is failing making it necessary to stop claiming efficacy gains via the EPR effect, while tumor targeting cannot be proved in the clinic...
November 18, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27865762/tumor-targeted-nanomedicines-for-cancer-theranostics
#14
Alexandra G Arranja, Vertika Pathak, Twan Lammers, Yang Shi
Chemotherapeutic drugs have multiple drawbacks, including severe side effects and suboptimal therapeutic efficacy. Nanomedicines assist in improving the biodistribution and target accumulation of chemotherapeutic drugs, and are therefore able to enhance the balance between efficacy and toxicity. Multiple types of nanomedicines have been evaluated over the years, including liposomes, polymer-drug conjugates and polymeric micelles, which rely on strategies such as passive targeting, active targeting and triggered release for improved tumor-directed drug delivery...
November 16, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27863668/nanotechnologies-for-the-treatment-of-colon-cancer-from-old-drugs-to-new-hope
#15
Larissa Kotelevets, Eric Chastre, Didier Desmaële, Patrick Couvreur
Colorectal cancer is a wide-reaching health problem due to its incidence and to the high mortality rates. Adjuvant chemotherapies have considerably improved the prognosis and/or the overall survival of patients with locally advanced and metastatic cancers. Nevertheless, their efficiency remains limited due to intrinsic and emerging multidrug resistance (MDR) of cancer cells, and to major adverse effects and dose limiting toxicities. The present review discusses the knowledge of clinically relevant mechanisms of resistance to cytotoxic and targeted therapies for the treatment of colorectal cancer, and focuses on the benefit of nanomedicine approach to circumvent these processes...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27862953/dual-stimuli-responsive-nanotheranostics-for-multimodal-imaging-guided-trimodal-synergistic-therapy
#16
Shan Fang, Jing Lin, Chunxiao Li, Peng Huang, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei Fan, Daxiang Cui, Yunsheng Xu, Zhiming Li
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27861850/nanomedicine-in-management-of-hepatocellular-carcinoma-challenges-and-opportunities
#17
REVIEW
Nourhan K Mohamed, Mostafa A Hamad, Mohamed Z E Hafez, Karen L Wooley, Mahmoud Elsabahy
Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of recent drug delivery attempts for the management of hepatocellular carcinoma with the aid of nanomedical structures is presented. The beneficial impact of nanomaterials in terms of prolonged retention in blood and target sites, controlled biodistribution and improved stability of the encapsulated payloads, will be described, together with the possibility of incorporating more than one cargo into the same nanostructure...
November 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27861510/heterogeneous-uptake-of-nanoparticles-in-mouse-models-of-pediatric-high-risk-neuroblastoma
#18
Ketan B Ghaghada, Zbigniew A Starosolski, Anna Lakoma, Caterina Kaffes, Saurabh Agarwal, Khannan K Athreya, Jason Shohet, Eugene Kim, Ananth Annapragada
Liposomal chemotherapeutics are exemplified by DOXIL® are commonly used in adult cancers. While these agents exhibit improved safety profile compared to their free drug counterparts, their treatment response rates have been ~ 20%, often attributed to the heterogeneous intratumoral uptake and distribution of liposomal nanoparticles. Non-invasive and quantitative monitoring of the uptake and distribution of liposomal nanoparticles in solid tumors could allow for patient stratification and personalized cancer nanomedicine...
2016: PloS One
https://www.readbyqxmd.com/read/27860237/modularized-gold-nanocarriers-for-tat-mediated-delivery-of-sirna
#19
Xiao Huang, Yifan Lai, Gary B Braun, Norbert O Reich
Targeted delivery of siRNA controlled by near-infrared light using hollow gold nanoshells has been demonstrated in cancer and stem cells models. Here, a universal surface module and several functionalization rules for the maximized delivery of short nucleic acids (here, siRNA) applicable for diverse gold nanocarriers are described. Streptavidin is devised as a handle to assemble biotinylated cell penetrating peptides (e.g., transactivating transcriptional activator (TAT)), as well as an insulator between the positive charge of TAT and the dense negative charge of RNA...
November 18, 2016: Small
https://www.readbyqxmd.com/read/27854161/nanomedicine-strategies-for-sustained-controlled-and-targeted-treatment-of-cancer-stem-cells
#20
Jie Gao, Wei Li, Yajun Guo, Si-Shen Feng
Cancer stem cells (CSCs) are original cancer cells that are of characteristics associated with normal stem cells. CSCs are toughest against various treatments and thus responsible for cancer metastasis and recurrence. Therefore, development of specific and effective treatment of CSCs plays a key role in improving survival and life quality of cancer patients, especially those in the metastatic stage. Nanomedicine strategies, which include prodrugs, micelles, liposomes and nanoparticles of biodegradable polymers, could substantially improve the therapeutic index of conventional therapeutics due to its manner of sustained, controlled and targeted delivery of high transportation efficiency across the cell membrane and low elimination by intracellular autophagy, and thus provide a practical solution to solve the problem encountered in CSCs treatment...
November 17, 2016: Nanomedicine
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