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https://www.readbyqxmd.com/read/29149720/a-robust-strategy-for-preparation-of-sequential-stimuli-responsive-block-copolymer-prodrugs-via-thiolactone-chemistry-to-overcome-multiple-anticancer-drug-delivery-barriers
#1
Wendong Ke, Wei Yin, Zengshi Zha, Jean Felix Mukerabigwi, Weijian Chen, Yuheng Wang, Chuanxin He, Zhishen Ge
Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution. However, a cascade of physiological barriers against specific delivery of drugs into tumor cells limit the final therapeutic efficacy. Herein, we report a robust and facile strategy based on thiolactone chemistry to fabricate well-defined BCPs with sequential tumor pH-promoted cellular internalization and intracellular stimuli-responsive drug release...
November 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29148694/ambient-aqueous-synthesis-of-ultrasmall-ni0-85se-nanoparticles-for-non-invasive-photoacoustic-imaging-and-combined-photothermal-chemo-therapy-of-cancer
#2
Xianwen Wang, Fei Li, Xu Yan, Yan Ma, Zhaohua Miao, Liang Dong, Huajian Chen, Yang Lu, Zhengbao Zha
Big size induced long-term retention in the body has hampered the translational applications of many reported nanomedicine. Herein, we reported a multifunctional theranostic agent composed of ultrasmall polyacrylic acid functionalized Ni0.85Se nanoparticles (PAA-Ni0.85Se NPs), which were successfully obtained through a facile ambient aqueous precipitation strategy. Without exhibiting any noticeable toxicity, the as-prepared PAA-Ni0.85Se NPs (average diameter of 6.40 ± 1.89 nm) showed a considerable absorption in near-infrared (NIR) region and high photothermal conversion efficiency (PTCE) of 54...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29144983/albumin-coordinated-assembly-of-clearable-platinum-nanodots-for-photo-induced-cancer-theranostics
#3
Yong'an Tang, Tao Yang, Qiaoli Wang, Xiaoyan Lv, Xue Song, Hengte Ke, Zhengqing Guo, Xiaoqing Huang, Jun Hu, Zifu Li, Peng Yang, Xiangliang Yang, Huabing Chen
Photoactive noble metal nanoparticles are of increasing importance toward personalized cancer therapy in the field of precision nanomedicine. A critical challenge remains in the exploration of clinically potential noble metal nanoparticles for highly efficient cancer theranostics. Here, we introduce albumin-coordinated assembly of clearable Pt nanodots (Pt-NDs) with monodisperse nanostructure as high-performance theranostic agents for imaging-guided photothermal tumor ablation. We precisely manipulate the reduction and growth of tetravalent Pt ions into ultrasmall nanodots through albumin-directed growth kinetics, thereby leading to the synthesis of monodisperse 6...
October 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/29143522/mmp-2-sensitive-ha-end-conjugated-poly-amidoamine-dendrimers-via-click-reaction-to-enhance-drug-penetration-into-solid-tumor
#4
Min Han, Ming-Yi Huang-Fu, Wang-Wei Guo, Ningning Guo, Jiejian Chen, Huina Liu, Zhiqi Xie, Mengting Lin, Qichun Wei, Jianqing Gao
Currently, the limited tumor penetration of nanoparticles remains a major challenge of cancer nanomedicine. Herein, we propose a size-shrinkable, drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29143214/cellular-processing-of-gold-nanoparticles-ce-icp-ms-evidence-for-the-speciation-changes-in-human-cytosol
#5
Joanna Legat, Magdalena Matczuk, Andrei R Timerbaev, Maciej Jarosz
The cellular uptake of gold nanoparticles (AuNPs) may (or may not) affect their speciation, but information on the chemical forms in which the particles exist in the cell remains obscure. An analytical method based on the use of capillary electrophoresis hyphenated with inductively coupled plasma mass spectrometry (ICP-MS) has been proposed to shed light on the intracellular processing of AuNPs. It was observed that when being introduced into normal cytosol, the conjugates of 10-50 nm AuNPs with albumin evolved in human serum stayed intact...
November 15, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29133898/intertwining-dna-rna-nanocapsules-loaded-with-tumor-neoantigens-as-synergistic-nanovaccines-for-cancer-immunotherapy
#6
Guizhi Zhu, Lei Mei, Harshad D Vishwasrao, Orit Jacobson, Zhantong Wang, Yijing Liu, Bryant C Yung, Xiao Fu, Albert Jin, Gang Niu, Qin Wang, Fuwu Zhang, Hari Shroff, Xiaoyuan Chen
Nanomedicines that co-deliver DNA, RNA, and peptide therapeutics are highly desirable yet remain underdeveloped for cancer theranostics. Herein, we report self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) that efficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as tumor-specific peptide neoantigens into antigen presenting cells (APCs) in lymph nodes for cancer immunotherapy. These nanovaccines were prepared by (1) producing tandem CpG and shRNA via concurrent rolling circle replication and rolling circle transcription, (2) self-assembling CpG and shRNA into DNA-RNA microflowers, (3) shrinking microflowers into iDR-NCs using PEG-grafted cationic polypeptides, and (4) physically loading neoantigen into iDR-NCs...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29127069/lectin-conjugated-ph-responsive-mesoporous-silica-nanoparticles-for-targeted-bone-cancer-treatment
#7
Marina Martínez-Carmona, Daniel Lozano, Montserrat Colilla, María Vallet-Regí
A novel multifunctional nanodevice based in doxorubicin (DOX)-loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consists of: i) a polyacrylic acid (PAA) capping layer grafted to MSNs via an acid-cleavable acetal linker, to minimize premature cargo release and provide the nanosystem of pH-responsive drug delivery ability; and ii) a targeting ligand, the plant lectin concanavalin A (ConA), able to selectively recognize, bind and internalize owing to certain cell-surface glycans, such as sialic acids (SA), overexpressed in given tumor cells...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29123399/multifunctional-gold-nanorods-and-docetaxel-encapsulated-liposomes-for-combined-thermo-and-chemotherapy
#8
Haiying Hua, Nan Zhang, Dan Liu, Lili Song, Tuanbing Liu, Shasha Li, Yongxing Zhao
Personalized and precise nanomedicines are highly demanded for today's medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29123332/target-or-clear-zirconium-89-labeled-silica-nanoparticles-for-enhanced-cancer-directed-uptake-in-melanoma-a-comparison-of-radiolabeling-strategies
#9
Feng Chen, Kai Ma, Li Zhang, Brian Madajewski, Pat Zanzonico, Sonia Sequeira, Mithat Gonen, Ulrich Wiesner, Michelle S Bradbury
Designing a nanomaterials platform with high target-to-background ratios has long been one of the major challenges in the field of nanomedicine. Here, we introduce a "target-or-clear" multifunctional nanoparticle platform that demonstrates high tumor-targeting efficiency and retention while minimizing off-target effects. Encouraged by the favorable preclinical and clinical pharmacokinetic profiles derived after fine-tuning surface chemical properties of radioiodinated ((124)I, t1/2 = 100.2 h) ultrasmall cRGDY-conjugated fluorescent silica nanoparticles (C dots), we sought to investigate how the biological properties of these radioconjugates could be influenced by the conjugation of radiometals such as zirconium-89 ((89)Zr, t1/2 = 78...
October 10, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/29116739/gold-nanocluster-mediated-cellular-death-under-electromagnetic-radiation
#10
Anna Cifuentes-Rius, Angela Ivask, Shreya Das, Nuria Penya Auladell, Laura Fabregas, Nicholas L Fletcher, Zachary H Houston, Kristofer James Thurecht, Nicolas H Voelcker
Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy due to their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to 1 GHz electromagnetic field (microwave radiation, µW), cell viability significantly decreases thus demonstrating that Au NCs exhibit specific µW dependent cytotoxicity, likely resulting from localized heating...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29109786/-one-pot-fabrication-of-highly-versatile-and-biocompatible-poly-vinyl-alcohol-porphyrin-based-nanotheranostics
#11
Yan Luo, Hao Wu, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-Yin Lin, Hongyong Zhang, Jeffrey H Walton, Yousif Ajena, Yide Hu, Kit S Lam, Yuanpei Li
Nanoparticle-based theranostic agents have emerged as a new paradigm in nanomedicine field for integration of multimodal imaging and therapeutic functions within a single platform. However, the clinical translation of these agents is severely limited by the complexity of fabrication, long-term toxicity of the materials, and unfavorable biodistributions. Here we report an extremely simple and robust approach to develop highly versatile and biocompatible theranostic poly(vinyl alcohol)-porphyrin nanoparticles (PPNs)...
2017: Theranostics
https://www.readbyqxmd.com/read/29109766/cancer-nanomedicines-stabilized-by-%C3%AF-%C3%AF-stacking-between-heterodimeric-prodrugs-enable-exceptionally-high-drug-loading-capacity-and-safer-delivery-of-drug-combinations
#12
Hangxiang Wang, Jianmei Chen, Chang Xu, Linlin Shi, Munire Tayier, Jiahui Zhou, Jun Zhang, Jiaping Wu, Zhijian Ye, Tao Fang, Weidong Han
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, the current drug combination therapy refers to administering individual drugs together, which is far from a perfect regimen for cancer patients. The aim of this work was to demonstrate that synergistic delivery of two chemotherapeutic drugs in a single nanoparticle reservoir could be achieved through the rational chemical ligation of the drugs followed by supramolecular nano-assembly via blending of the drugs with a minimal amount of matrix...
2017: Theranostics
https://www.readbyqxmd.com/read/29107128/targeted-cancer-therapy-through-antibody-fragments-decorated-nanomedicines
#13
REVIEW
Abbas Alibakhshi, Fatemeh Abarghooi Kahaki, Shahrzad Ahangarzadeh, Hajar Yaghoobi, Fatemeh Yarian, Roghaye Arezumand, Javad Ranjbari, Ahad Mokhtarzadeh, Miguel de la Guardia
Active targeting in cancer nanomedicine, for improved delivery of agents and diagnose, has been reviewed as a successful way for facilitating active uptake of theranostic agents by the tumor cells. The application of a targeting moiety in the targeted carrier complexes can play an important role in differentiating between tumor and healthy tissues. The pharmaceutical carriers, as main part of complexes, can be polymeric nanoparticles, micelles, liposomes, nanogels and carbon nanotubes. The antibodies are among the natural ligands with highest affinity and specificity to target pharmaceutical nanoparticle conjugates...
November 3, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29104854/chirality-controls-reaction-diffusion-of-nanoparticles-for-inhibiting-cancer-cells
#14
Xuewen Du, Jie Zhou, Jiaqing Wang, Rong Zhou, Bing Xu
Reaction-diffusion (RD) is the most important inherent feature of living organism, but it has yet to be used for developing biofunctional nanoparticles (NPs). Here we show the use of chirality to control the RD of NPs for selectively inhibiting cancer cells. We observe that L-phosphotyrosine (L-pY) decorated NPs (NP@L-pYs) are innocuous to cells, but D-pY decorated ones (NP@D-pYs) selectively inhibit cancer cells. Our study shows that alkaline phosphatases (ALP), presented in the culture and overexpressed on the cancer cells, dephosphorylates NP@L-pYs much faster than NP@D-pYs...
January 2017: ChemNanoMat: Chemistry of Nanomaterials for Energy, Biology and More
https://www.readbyqxmd.com/read/29098929/current-prospects-and-challenges-of-nanomedicine-delivery-in-prostate-cancer-therapy
#15
Santosh Gupta, Piyush Kumar Gupta, Gunasekaren Dharanivasan, Rama Shanker Verma
Management of prostate cancer is currently being pursued by systemic delivery of anticancer drugs, but it has drawbacks like nonspecific distribution, decreased bioavailability, coupled with adverse side effects. These problems have been resolved using nanomedicine-based anticancer drug delivery to improve the therapeutic index with higher drug dose and reduced nonspecific distribution. Targeting prostate tumor by delivering nanomedicine through locoregional route is more effective, than the systemic delivery, which can decrease systemic exposure of the therapeutics significantly...
November 3, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29092925/correction-a-squalene-based-nanomedicine-for-oral-treatment-of-colon-cancer
#16
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29088978/the-biological-challenges-and-pharmacological-opportunities-of-orally-administered-nanomedicine-delivery
#17
Darren Michael Moss, Paul Curley, Hannah Kinvig, Clare Hoskins, Andrew Owen
Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being investigated. The mucosal surface of the gastrointestinal tract is capable of trapping and eliminating large particles and pathogens as part of the natural defences of the body, it is becoming clearer that nanoformulation properties such as particle size, charge, and shape, as well as mucous properties such as viscoelasticity, thickness, density, and turn-over time are all relevant to these interactions...
November 1, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29082766/new-developments-and-clinical-transition-of-hyaluronic-acid-based-nanotherapeutics-for-treatment-of-cancer-reversing-multidrug-resistance-tumour-specific-targetability-and-improved-anticancer-efficacy
#18
Muhammad Hassan Safdar, Zahid Hussain, Mohammed A S Abourehab, Humna Hasan, Sajal Afzal, Hnin Ei Thu
This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in cancer therapy, various hyaluronic acid (HA)-conjugated nanomedicines have been fabricated owing to their biocompatibility, safety, tumour-specific targetability of drugs and genes, and proficient interaction with cluster-determinant-44 (CD44) receptors over-expressed on the surface of tumour cells...
October 30, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29076344/exploration-of-zinc-oxide-nanoparticles-as-a-multitarget-and-multifunctional-anticancer-nanomedicine
#19
Jiao Wang, Jung Seok Lee, Dongin Kim, Lin Zhu
Because of the complexity of cancer, an ideal anticancer strategy is better to target both cancer cells and the tumor microenvironment. In this study, for the first time, we demonstrated that zinc oxide nanoparticles (ZnO NPs) were able to target multiple cell types of cancer, including cancer cells, cancer stem cells (CSCs), and macrophages, and simultaneously perform several key functions, including inhibition of cancer proliferation, sensitization of drug-resistant cancer, prevention of cancer recurrence and metastasis, and resuscitation of cancer immunosurveillance...
November 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29075517/rethinking-cancer-nanotheranostics
#20
Hongmin Chen, Weizhong Zhang, Guizhi Zhu, Jin Xie, Xiaoyuan Chen
Advances in nanoparticle synthesis and engineering have produced nanoscale agents affording both therapeutic and diagnostic functions that are often referred to by the portmanteau 'nanotheranostics'. The field is associated with many applications in the clinic, especially in cancer management. These include patient stratification, drug-release monitoring, imaging-guided focal therapy and post-treatment response monitoring. Recent advances in nanotheranostics have expanded this notion and enabled the characterization of individual tumours, the prediction of nanoparticle-tumour interactions, and the creation of tailor-designed nanomedicines for individualized treatment...
2017: Nature Reviews. Materials
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