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https://www.readbyqxmd.com/read/29147785/qt-interval-and-dispersion-in-drug-free-anorexia-nervosa-adolescents-a-case-control-study
#1
Monica Bomba, Lucio Tremolizzo, Fabiola Corbetta, Franco Nicosia, Francesca Lanfranconi, Gianni Poggioli, Karine Goulene, Marco Stramba-Badiale, Elisa Conti, Francesca Neri, Renata Nacinovich
Long QT values have been reported in patients with anorexia nervosa of the restricting type (ANr) potentially increasing the risk of fatal arrhythmia, especially if psychotropic drug treatment is required. Nevertheless, the previous studies on this topic are biased by drug exposure, long disease durations, and small sample sizes. This study is aimed at assessing QTc and QTcd values in ANr adolescents with recent onset and drug free, as compared to subjects affected by psychiatric disorders other than ANr. We evaluated QTc and its dispersion (QTcd) in a population of 77 drug-free ANr female adolescents and compared to an equal number of healthy controls (H-CTRL) and pathological controls (P-CTRL, mixed psychiatric disorders)...
November 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29143062/-intracranial-cystic-lesions
#2
REVIEW
F Ahlhelm, K Shariat, S Götschi, S Ulmer
CLINICAL PROBLEM: Intracerebral cysts are common findings in imaging of the neurocranium and are not always clinically significant. The pathological spectrum of intracerebral cysts is, however, very broad and in addition to incidental findings includes developmental disorders, malformation tumors, primary and secondary neoplasms and infectious etiologies, such as cerebral abscess formation, cysticercosis or residuals after congenital cytomegalovirus infections. Intracerebral cystic defects may be caused by inflammatory central nervous system (CNS) diseases, such as multiple sclerosis as well as by mitochondriopathies, leukodystrophy, electrolyte disturbances or osmotic demyelination syndrome or brain infarctions, e...
November 15, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29134993/the-promoting-effect-of-tetravalent-cerium-on-the-oxygen-evolution-activity-of-copper-oxide-catalysts
#3
Zhu Chen, Coleman X Kronawitter, Xiaofang Yang, Yao-Wen Yeh, Nan Yao, Bruce E Koel
A new catalyst is presented for the oxygen evolution reaction (OER) based on cerium-modified copper oxide (CuOx) prepared using a facile electrodeposition procedure. Incorporation of Ce into CuOx leads to greatly improved OER activity, which reached an optimal value at a surface concentration of 6.9 at% Ce. Specifically, the OER current density at 400 mV overpotential for the most active Ce-modified CuOx catalyst (6.9 at% Ce) was 3.3 times greater compared to the pure CuOx. Coincident with the improved OER activity, Ce incorporation also leads to significant structural changes that manifested in increasing degrees of disorder...
November 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29121712/epidemiologic-incidence-of-rhabdomyolysis-in-opioid-overdose-in-icu-of-poisoning-center-in-iran-2014
#4
Babak Khoshideh, Mohammad Arefi, Mazaher Ghorbani, Samaneh Akbarpour, Fatemeh Taghizadeh
Objectives: The aim of this study is to investigate the clinical, demographical characteristics and some laboratory findings of hospitalized patients with acute opioid toxicity and rhabdomyolysis. Methods: In this cross-sectional study, 354 hospitalized patients were investigated at Baharloo Educational Hospital in Tehran, with acute illicit drug toxicity in 2014. Data was collected by an investigator-made check lists. The collected data and variations (such as mortality rate, demographic data, and renal function tests as well as serum biochemical elements) were analyzed by descriptive statistics and x-square test...
November 8, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29118340/the-liquid-glass-jamming-transition-in-disordered-ionic-nanoemulsions
#5
Marco Braibanti, Ha Seong Kim, Nesrin Şenbil, Matthew J Pagenkopp, Thomas G Mason, Frank Scheffold
In quenched disordered out-of-equilibrium many-body colloidal systems, there are important distinctions between the glass transition, which is related to the onset of nonergodicity and loss of low-frequency relaxations caused by crowding, and the jamming transition, which is related to the dramatic increase in elasticity of the system caused by the deformation of constituent objects. For softer repulsive interaction potentials, these two transitions become increasingly smeared together, so measuring a clear distinction between where the glass ends and where jamming begins becomes very difficult or even impossible...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117755/contribution-of-oxidative-stress-in-acute-intestinal-mucositis-induced-by-5-fluorouracil-5-fu-and-its-pro-drug-capecitabine-in-rats
#6
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Mohamed Amri, Hichem Sebai, Lamjed Marzouki
This study was designed to examine the contribution of oxidative stress in gastrointestinal disorders after an intraperitoneal administration of 5-FU (100mg/kg b.w.) and capecitabine oral administration (500mg/kg b.w.). The animals were divided into three groups: Group A (NaCl, 10ml/kg b.w.) considered as control group, group B was intoxicated by 5-FU and the group of animals (group C) treated with capecitabine (CAP). To evaluate the secretory and enteropooling effects, we were used as a hypersecretion agent (MgSO4, 1ml/100g b...
November 8, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29114754/acute-kidney-injury
#7
REVIEW
Andrew S Levey, Matthew T James
Acute kidney injury is a heterogeneous group of conditions characterized by a sudden decrease in glomerular filtration rate, manifested by an increase in serum creatinine concentration or oliguria, and classified by stage and cause. This type of injury occurs in approximately 20% of hospitalized patients, with major complications including volume overload, electrolyte disorders, uremic complications, and drug toxicity. Management includes specific treatments according to the underlying cause and supportive treatment to prevent and manage complications...
November 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29081151/-effects-of-preconditioning-with-hypertonic-saline-solution-on-postoperative-delirium-in-the-aged
#8
X Xin, S P Huo, Q Zhang, Y N Li, L Wang, Q J Wang
Objective: To evaluate and explore the mechanism of the effect of hypertonic pre-injection on postoperative delirium in the aged. Methods: From June 2016 to February 2017, participants scheduled hip arthroplasty surgery were randomly divided into four groups: Group 1 (H1) 30 patients pre-injected 4 ml/kg hypertonic solution were proceeded general anesthesia; Group 2 (H2) 30 patients pre-injected 4 ml/kg hypertonic solution were proceeded spinal canal anesthesia; Group 3 (C1) 30 patients pre-injected 4 ml/kg isotonic saline were proceeded general anesthesia; Group 4 (C2) 30 patients pre-injected 4 ml/kg isotonic saline were proceeded spinal canal anesthesia in Department of Anesthesiology, Third Hospital of Hebei Medical University...
October 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29076984/prediction-model-of-in-hospital-mortality-after-hip-fracture-surgery
#9
Atsushi Endo, Heather J Baer, Masashi Nagao, Michael J Weaver
OBJECTIVES: Mortality in elderly patients after the surgical treatment of hip fractures remains high. While individual clinical risk factors have been widely studied, there has been limited research on prediction models in this population. The purpose of this study was to develop a prediction model for in-hospital mortality after hip fracture surgery and to evaluate the performance of this model. METHODS: Using the National Inpatient Sample database from 2012 to 2013, we collected data on 535,475 patients with age over 50 who had hip fracture surgery...
September 25, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29069243/ventricular-arrhythmia-in-chronic-kidney-disease-patients
#10
Fabiana Oliveira Bastos Bonato, Maria Eugênia Fernandes Canziani
Patients with chronic kidney disease (CKD) are susceptible to the occurrence of ventricular arrhythmias. The leading cause of death in dialysis patients is cardiac arrhythmias. The pathophysiology of arrhythmias in this population is complex and seems to be related to structural cardiac abnormalities caused by CKD, associated with several triggers, such as water and electrolyte disorders, hormonal conditions, arrhythmogenic drugs, and the dialysis procedure itself. Little is known about the clinical outcomes in CKD patients with asymptomatic ventricular arrhythmias...
April 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29067525/hypernatremia-and-acute-pancreatitis-in-chronic-kidney-disease-back-to-the-salt-mines-questions
#11
Marie de Tersant, Thérésa Kwon, Marie-Alice Macher, Anne Maisin, Georges Deschênes, Olivier Niel
BACKGROUND: Acute pancreatitis can be a life-threatening complication in patients with chronic kidney disease (CKD), especially in kidney transplant recipients. CASE DIAGNOSIS/TREATMENT: The patient was 7 years old when he received renal transplantation for CKD secondary to posterior urethral valves. Two years later, he presented with severe necrotizing pancreatitis (Ranson's score 5, Balthazar's score 8). Viral and genetic testing came back negative; pancreatitis was attributed to the patient's treatments (prednisone, trimethoprim-sulfamethoxazole, and everolimus)...
October 24, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29064260/deterioration-of-limb-muscle-function-during-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#12
Raolat M Abdulai, Tina Jellesmark Jensen, Naimish R Patel, Michael I Polkey, Paul Jansson, Bartolomé R Celli, Stephen I Rennard
Important features of both stable and acute exacerbation of COPD are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributing factors leading to muscle dysfunction are similar to those seen in stable COPD: disuse, nutrition/energy balance, hypercapnia, hypoxemia, electrolyte derangements, inflammation, and drugs (i.e., glucocorticoids). These factors may be the trigger for a downstream cascade of local inflammatory changes, pathway process alterations, and structural degradation...
October 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29058194/characterization-of-mc4r-regulation-of-the-kir7-1-channel-using-the-tl-flux-assay
#13
Michael J Litt, Roger D Cone, Masoud Ghamari-Langroudi
The family of inward rectifying potassium channels (Kir channels) plays crucial roles in the regulation of heart rhythms, renal excretion, insulin release, and neuronal activity. Their dysfunction has been attributed to numerous diseases such as cardiac arrhythmia, kidney failure and electrolyte imbalance, diabetes mellitus, epilepsy, retinal degeneration, and other neuronal disorders. We have recently demonstrated that the melanocortin-4 receptor (MC4R), a Gαs-coupled GPCR, regulates Kir7.1 activity through a mechanism independent of Gαs and cAMP...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29058016/resculpting-the-binding-pocket-of-apc-superfamily-leut-fold-amino-acid-transporters
#14
Noel Edwards, Catriona M H Anderson, Nichola J Conlon, Andrew K Watson, Rebecca J Hall, Timothy R Cheek, T Martin Embley, David T Thwaites
Amino acid transporters are essential components of prokaryote and eukaryote cells, possess distinct physiological functions, and differ markedly in substrate specificity. Amino acid transporters can be both drug targets and drug transporters (bioavailability, targeting) with many monogenic disorders resulting from dysfunctional membrane transport. The largest collection of amino acid transporters (including the mammalian SLC6, SLC7, SLC32, SLC36, and SLC38 families), across all kingdoms of life, is within the Amino acid-Polyamine-organoCation (APC) superfamily...
October 23, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29044308/heart-conduction-system-defects-and-sustained-ventricular-tachycardia-complications-in-a-patient-with-granulomatosis-with-polyangiitis-a-case-report-and-literature-review
#15
Laryssa Passos Sarmento Santos, Victor Guerreiro Bomfim, Camila Fagundes Bezerra, Natália Vieira Costa, Rafael Barreto Paes de Carvalho, Ricardo Sobral de Carvalho, Rogério da Hora Passos, Olivia Carla Bomfim Boaventura, André Luiz Nunes Gobatto
Granulomatosis with polyangiitis is a rare systemic inflammatory disorder characterized by vasculitis of the small arteries, the arterioles and the capillaries together with necrotizing granulomatous lesions. This case reports on a young female patient, previously diagnosed with granulomatosis with polyangiitis, who was admitted to the intensive care unit with seizures and hemodynamic instability due to a complete atrioventricular heart block. The event was associated with multiple episodes of sustained ventricular tachycardia without any structural heart changes or electrolyte disturbances...
July 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29035028/stress-mediated-enhancement-of-ionic-conductivity-in-fast-ion-conductors
#16
Arun K Sagotra, Claudio Cazorla
Finding solid-state electrolytes with high ionic conductivity near room temperature is an important prerequisite for developing all-solid-state electrochemical batteries. Here, we investigate the effects of point defects (vacancies) and biaxial stress on the superionic properties of fast-ion conductors (represented by the archetypal compounds CaF2, Li-rich antiperovskite Li3OCl, and AgI) by using classical molecular dynamics and first-principles simulation methods. We find that the critical superionic temperature of all analyzed families of fast-ion conductors can be reduced by several hundreds of degrees through the application of relatively small biaxial stresses (|σ| ≤ 1 GPa) on slightly defective samples (cv ∼ 1%)...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29028089/the-productions-of-atrial-natriuretic-peptide-and-arginine-vasopressin-in-small-cell-lung-cancer-with-brain-metastases-and-their-associations-with-hyponatremia
#17
N-H Sun, S-H Wang, J-N Liu, A Liu, W-J Gong, Y Liu, P Sun, H Li
OBJECTIVE: Hyponatremia is one of the most frequently encountered electrolyte disorder in small cell lung cancer (SCLC) patients. It was shown that some SCLC cell lines could produce atrial natriuretic peptide (ANP) and arginine vasopressin (AVP). The aim of the study was to assess the secretion of ANP, AVP and their relative contributions to hyponatremia in SCLC patients, especially in patients with brain metastases. PATIENTS AND METHODS: In total, 194 SCLC patients including 51 patients with brain metastases were collected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026589/a-retrospective-analysis-of-biochemical-and-haematological-parameters-in-patients-with-eating-disorders
#18
Leanne J Barron, Robert F Barron, Jeremy C S Johnson, Ingrid Wagner, Cameron J B Ward, Shannon R B Ward, Faye M Barron, Warren K Ward
BACKGROUND: The objective of the study was to determine whether levels of biochemical and haematological parameters in patients with eating disorders (EDs) varied from the general population. Whilst dietary restrictions can lead to nutritional deficiencies, specific abnormalities may be relevant to the diagnosis, pathogenesis and treatment of EDs. METHODS: With ethics approval and informed consent, a retrospective chart audit was conducted of 113 patients with EDs at a general practice in Brisbane, Australia...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29016233/metabolic-complications-of-home-parenteral-nutrition
#19
Jamie Davila, Denise Konrad
Home parenteral nutrition (HPN) has benefited countless patients since its initiation almost 5 decades ago. Over time, HPN has been found to be associated with various complications, including metabolic disorders. Metabolic complications can be grouped into short-term (eg, fluid imbalance, electrolyte disturbances, glucose abnormalities) and long-term (eg, hepatobiliary disorders, metabolic bone disease, iron deficiency anemia, manganese toxicity) categories. There are a number of treatment options for each complication...
December 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28994854/alkoholketoacidos-%C3%A3-r-en-v%C3%A3-l-dokumenterad-men-t%C3%A3-mligen-ok%C3%A3-nd-diagnos-m%C3%A3-jlig-orsak-till-d%C3%A3-dsfall-bland-personer-med-alkoholproblem
#20
Jonas Höjer
Alcoholic ketoacidosis - a review A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem in the emergency room. Over and above methanol- and ethylene glycol intoxication, alcoholic ketoacidosis is a common but less recognized etiology. The disorder occurs in alcoholics who have had a recent binge drinking followed by the abrupt cessation of alcohol consumption because of abdominal pain and vomiting, with resulting dehydration, starvation, and then a β-hydroxybutyrate dominated ketoacidosis...
October 3, 2017: Läkartidningen
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