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https://www.readbyqxmd.com/read/29786428/electrochemical-impedance-spectroscopy-for-real-time-detection-of-lipid-membrane-damage-based-on-a-porous-self-assembly-monolayer-support
#1
Meng Zhang, Qingyu Zhai, Liping Wan, Li Chen, Yu Peng, Chunyan Deng, Juan Xiang, Jiawei Yan
Layer-by-layer dissolution and permeable pore formation are two typical membrane damage pathways, which induce membrane function disorder and result in serious disease, such as Alzheimer's disease, Keshan disease, Sickle-cell disease and so on. To effectively distinguish and sensitively monitor these two typical membrane damage pathways, a facile electrochemical impedance strategy was developed on a porous self-assembly monolayer (pSAM) supported bilayer lipid membrane (BLM). The pSAM was prepared by selectively electrochemical reductive desorption of the mercaptopropionic acid in a mixed mercaptopropionic acid/11-mercaptoundecanoic acid self-assembled monolayer, which created plenty of nanopores with tens of nanometers in diameter and several nanometers in height (defined as inner-pores)...
May 22, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29773358/-antidepressive-agents-and-hyponatremia-a-literature-review-and-a-case-non-case-study-in-the-french-pharmacovigilance-database
#2
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
https://www.readbyqxmd.com/read/29757121/management-of-electrolyte-disorders-also-the-method-matters
#3
Joris Richard Delanghe
INTRODUCTION: For the last few decades, electrolyte determinations in plasma or serum are carried out by reliable potentiometric methods. In recent years, a marked technical evolution has taken place, where the clinical analysis of common analytes (e.g. electrolytes) is partly moving from centralised clinical core laboratories to near-patient point-of-care testing. METHODS: As the measuring principle used by point-of-care testing markedly differs from the one used in core laboratories, sodium results are not always interchangeable in critically ill patients due to the different sensitivity of the analytical methods for the electrolyte exclusion effect...
May 14, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29751506/neurocognitive-disorders-and-dehydration-in-older-patients-clinical-experience-supports-the-hydromolecular-hypothesis-of-dementia
#4
Michele Lauriola, Antonio Mangiacotti, Grazia D'Onofrio, Leandro Cascavilla, Francesco Paris, Giulia Paroni, Davide Seripa, Antonio Greco, Daniele Sancarlo
Abnormalities of water homeostasis can be early expressions of neuronal dysfunction, brain atrophy, chronic cerebrovasculopathy and neurodegenerative disease. The aim of this study was to analyze the serum osmolality of subjects with cognitive impairment. One thousand and ninety-one consecutive patients attending the Alzheimer’s Evaluation Unit were evaluated with the Mini-Mental State Examination (MMSE), 21-Item Hamilton Depression Rating Scale (HDRS-21), Activities of Daily Living (ADL), Instrumental-ADL (IADL), Mini Nutritional Assessment (MNA), Exton-Smith Scale (ESS), and Cumulative Illness Rating Scale (CIRS)...
May 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29740578/using-electrolyte-free-water-balance-to-rationalize-and-treat-dysnatremias
#5
REVIEW
Sanjeev R Shah, Gautam Bhave
Dysnatremias or abnormalities in plasma [Na+ ] are often termed disorders of water balance, an unclear physiologic concept often confused with changes in total fluid balance. However, most clinicians clearly recognize that hypertonic or hypotonic gains or losses alter plasma [Na+ ], while isotonic changes do not modify plasma [Na+ ]. This concept can be conceptualized as the electrolyte free water balance (EFWB), which defines the non-isotonic components of inputs and outputs to determine their effect on plasma [Na+ ]...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29737913/pathophysiology-of-ibd-associated-diarrhea
#6
Arivarasu N Anbazhagan, Shubha Priyamvada, Waddah A Alrefai, Pradeep K Dudeja
Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing prevalence worldwide. The etiology of the disease is complex and involves a combination of genetic, environmental, immunological and gut microbial factors. Recurring and bloody diarrhea is the most prevalent and debilitating symptom in IBD. The pathogenesis of IBD-associated diarrhea is multifactorial and is essentially an outcome of mucosal damage caused by persistent inflammation resulting in dysregulated intestinal ion transport, impaired epithelial barrier function and increased accessibility of the pathogens to the intestinal mucosa...
May 8, 2018: Tissue Barriers
https://www.readbyqxmd.com/read/29731287/controversies-in-management-of-hyperkalemia
#7
Brit Long, Justin R Warix, Alex Koyfman
BACKGROUND: Hyperkalemia is a common electrolyte disorder that can result in morbidity and mortality if not managed appropriately. OBJECTIVES: This review evaluates the classic treatments of hyperkalemia and discusses controversies and new medications for management. DISCUSSION: Potassium (K+) plays a key role in determining the transmembrane potentials of "excitable membranes" present in nerve and muscle cells. K+ is the predominant intracellular cation, and clinical deterioration typically ensues when patients develop sufficiently marked elevation in extracellular fluid concentrations of K+ (hyperkalemia)...
May 3, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29728558/defect-enriched-iron-fluoride-oxide-nanoporous-thin-films-bifunctional-catalyst-for-water-splitting
#8
Xiujun Fan, Yuanyue Liu, Shuai Chen, Jianjian Shi, Juanjuan Wang, Ailing Fan, Wenyan Zan, Sidian Li, William A Goddard, Xian-Ming Zhang
Developing cost-effective electrocatalysts operated in the same electrolyte for water splitting, including oxygen and hydrogen evolution reactions, is important for clean energy technology and devices. Defects in electrocatalysts strongly influence their chemical properties and electronic structures, and can dramatically improve electrocatalytic performance. However, the development of defect-activated electrocatalyst with an efficient and stable water electrolysis activity in alkaline medium remains a challenge, and the understanding of catalytic origin is still limited...
May 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29722015/east-sesame-syndrome-review-of-the-literature-and-introduction-of-four-new-latvian-patients
#9
REVIEW
C Marta, M Ieva, I Inna, A Mareta, K Sandra, J Pereca, S Janis, P Dita, S Jurgis
EAST (Epilepsy, Ataxia, Sensorineural deafness, Tubulopathy) or SeSAME (Seizures, Sensorineural deafness, Ataxia, Mental retardation, and Electrolyte imbalance) syndrome is a rare autosomal recessive syndrome first described in 2009 independently by Bockenhauer and Scholl. It is caused by mutations in KCNJ10, which encodes Kir4.1, an inwardly rectifying K+ channel found in the brain, inner ear, kidney and eye. To date, 16 mutations in at least 28 patients have been reported. In this paper, we review mutations causing EAST/SeSAME syndrome, clinical manifestations in detail, and efficacy of treatment in previously reported patients...
May 3, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29717541/simultaneous-stabilization-of-lini0-76mn0-14co0-10o2-cathode-and-lithium-metal-anode-by-libob-additive
#10
Wengao Zhao, Lianfeng Zou, Jianming Zheng, Haiping Jia, Junhua Song, Mark H Engelhard, Chongmin Wang, Wu Xu, Yong Yang, Ji-Guang Zhang
The long-term cycling performance, rate capability, and voltage stability of lithium (Li) metal batteries with LiNi0.76Mn0.14Co0.10O2 (NMC76) cathodes is greatly enhanced by lithium bis(oxalato)borate (LiBOB) additive in the LiPF6-based electrolyte. With 2% LiBOB in the electrolyte, a Li||NMC76 cell is able to achieve a high capacity retention of 96.8% after 200 cycles at C/3 rate (1C = 200 mA g-1), which is the best result reported for a Ni-rich NMC cathode coupled with Li metal anode. The significantly enhanced electrochemical performance can be ascribed to the stabilization of both the NMC76-cathode/electrolyte and Li-metal-anode/electrolyte interfaces...
May 1, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29710234/association-of-postoperative-readmissions-with-surgical-quality-using-a-delphi-consensus-process-to-identify-relevant-diagnosis-codes
#11
Hillary J Mull, Laura A Graham, Melanie S Morris, Amy K Rosen, Joshua S Richman, Jeffery Whittle, Edith Burns, Todd H Wagner, Laurel A Copeland, Tyler Wahl, Caroline Jones, Robert H Hollis, Kamal M F Itani, Mary T Hawn
Importance: Postoperative readmission data are used to measure hospital performance, yet the extent to which these readmissions reflect surgical quality is unknown. Objective: To establish expert consensus on whether reasons for postoperative readmission are associated with the quality of surgery in the index admission. Design, Setting, and Participants: In a modified Delphi process, a panel of 14 experts in medical and surgical readmissions comprising physicians and nonphysicians from Veterans Affairs (VA) and private-sector institutions reviewed 30-day postoperative readmissions from fiscal years 2008 through 2014 associated with inpatient surgical procedures performed at a VA medical center between October 1, 2007, and September 30, 2014...
April 18, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29705780/a-case-of-ventricular-fibrillation-in-a-frail-patient-with-chronic-obstructive-pulmonary-disease-obstructive-sleep-apnea-syndrome-and-electrolytic-disorder
#12
Nicola Marchitto, Monica Mauti, Simona Andreozzi, Alberto Pannozzi, Serenella G Dalmaso, Gianfranco Raimondi
Chronic obstructive pulmonary disease (COPD) is associated with an increased cardiovascular risk, although the pathophysiological mechanisms responsible for this interdependence are not completely known. For instance, the increased sympathetic activity may be implied. The severity of COPD correlates with various arrhythmic manifestations such as atrial fibrillation, atrial flutter, and either sustained or nonsustained ventricular tachycardia. COPD and obstructive sleep apnea syndrome may increase the overall cardiovascular risk, especially in elderly patients...
2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29693392/unique-proton-transportation-pathway-in-a-robust-inorganic-coordination-polymer-leading-to-intrinsically-high-and-sustainable-anhydrous-proton-conductivity
#13
Daxiang Gui, Xing Dai, Zetian Tao, Tao Zheng, Xiangxiang Wang, Mark A Silver, Jie Shu, Lanhua Chen, Yanlong Wang, Tiantian Zhang, Jian Xie, Lin Zou, Yuanhua Xia, Jujia Zhang, Jin Zhang, Ling Zhao, Juan Diwu, Ruhong Zhou, Zhifang Chai, Shuao Wang
Although comprehensive progress has been made in the area of coordination polymer (CP)/metal-organic framework (MOF)-based proton conducting materials over the past decade, searching for a CP/MOF with stable, intrinsic, high anhydrous proton conductivity that can be directly used as a practical electrolyte in an intermediate-temperature proton-exchange membrane fuel cell (PEMFC) assembly for durable power generation remains a substantial challenge. Here, we introduce a new proton conducting CP, (NH4)3[Zr(H2/3PO4)3] (ZrP), which consists of one-dimensional zirconium phosphate anionic chains and fully ordered charge-balancing NH4+ cations...
April 25, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29687987/n-allyl-n-n-bis-trimethylsilyl-amine-as-a-novel-electrolyte-additive-to-enhance-the-interfacial-stability-of-ni-rich-electrode-for-lithium-ion-batteries
#14
Qinfeng Zheng, Lidan Xing, Xuerui Yang, Xiangfeng Li, Changchun Ye, Kang Wang, Qiming Huang, Weishan Li
Enhancing the electrode/electrolyte interface stability of high capacity LiNi0.8Co0.15Al0.05O2 (LNCA) cathode material is urgently required for its application in next generation lithium ion battery. Herein, we demonstrate that enhanced interfacial stability of LNCA can be achieved by simply introducing 2 wt. % N-Allyl-N,N-bis(trimethylsilyl)amine (NNB) electrolyte additive. Electrolyte oxidation reactions and transition metal ion dissolution are greatly suppressed in the electrolyte with NNB additive, leading to improved cyclic stability of LNCA from 72...
April 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29681012/critical-gaps-in-the-medical-knowledge-base-of-eating-disorders
#15
REVIEW
Dennis Gibson, Anne Drabkin, Mori J Krantz, Margherita Mascolo, Elissa Rosen, Katherine Sachs, Christine Welles, Philip S Mehler
Eating disorders are unique in that they inherently have much medical comorbidity both as a part of restricting-type eating disorders and those characterized by purging behaviors. Over the last three decades, remarkable progress has been made in the understanding and treatment of the medical complications of eating disorders. Yet, unfortunately, there is much research that is sorely needed to bridge the gap between current medical knowledge and more effective and evidence-based medical treatment knowledge. These gaps exist in many different clinical areas including cardiology, electrolytes, gastrointestinal and bone disease...
April 21, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29670391/determining-30-day-readmission-risk-for-heart-failure-patients-the-readmission-after-heart-failure-scale
#16
Ronald S Chamberlain, Jaswinder Sond, Krishnaraj Mahendraraj, Christine Sm Lau, Brianna L Siracuse
Background: Chronic heart failure (CHF), which affects >5 million Americans, accounts for >1 million hospitalizations annually. As a part of the Hospital Readmission Reduction Program, the Affordable Care Act requires that the Centers for Medicare and Medicaid Services reduce payments to hospitals with excess readmissions. This study sought to develop a scale that reliably predicts readmission rates among patients with CHF. Methods: The State Inpatient Database (2006-2011) was utilized, and discharge data including demographic and clinical characteristics on 642,448 patients with CHF from California and New York (derivation cohort) and 365,359 patients with CHF from Florida and Washington (validation cohort) were extracted...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29668907/the-mineralocorticoid-receptor-as-a-modulator-of-innate-immunity-and-atherosclerosis
#17
Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
The mineralocorticoid receptor (MR) is a member of the nuclear receptor steroid-binding family. The classical MR ligand aldosterone controls electrolyte and fluid homeostasis after binding in renal epithelial cells. However, more recent evidence suggests that activation of extrarenal MRs by aldosterone negatively impacts cardiovascular health independent of its effects on blood pressure: high levels of aldosterone associate with an increased cardiovascular event rate, where MR antagonists exert beneficial effects on cardiovascular mortality...
April 16, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29657194/association-of-brucellosis-with-renal-tubular-and-glomerular-damage-in-children-in-turkey
#18
Secil Conkar, Muhammed Kosker, Saliha Cevik, Muzeyyen Ay
Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Until now, no studies have been performed on renal tubular disorders in patients with brucellosis. The present study aims to investigate renal tubular disorders in patients with brucellosis. This prospective case-control study includes a total of 31 brucellosis patients (Group 1) and 30 healthy controls (Group 2) matched for age and sex. Renal tubular functions of children who were diagnosed as having brucellosis in outpatient pediatric clinics were evaluated...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29656932/a-higher-calorie-refeeding-protocol-does-not-increase-adverse-outcomes-in-adult-patients-with-eating-disorders
#19
Kylie Matthews, Jan Hill, Shane Jeffrey, Susan Patterson, Amanda Davis, Warren Ward, Michelle Palmer, Sandra Capra
BACKGROUND: Patients with eating disorders (EDs) are often considered a high-risk population to refeed. Current research advises using "start low, go slow" refeeding methods (∼1,000 kcal/day, advancing ∼500 kcal/day every 3 to 4 days) in adult patients with severe EDs to prevent the development of refeeding syndrome (RFS), typically characterized by decreases in serum electrolyte levels and fluid shifts. OBJECTIVE: To compare the incidence of RFS and related outcomes using a low-calorie protocol (LC) (1,000 kcal) or a higher-calorie protocol (HC) (1,500 kcal) in medically compromised adult patients with EDs...
April 12, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29623210/new-onset-insulin-dependent-diabetes-due-to-nivolumab
#20
Ali A Zaied, Halis K Akturk, Richard W Joseph, Augustine S Lee
Nivolumab, a monoclonal antibody against programmed cell death-1 receptor, is increasingly used in advanced cancers. While nivolumab use enhances cancer therapy, it is associated with increased immune-related adverse events. We describe an elderly man who presented in ketoacidosis after receiving nivolumab for metastatic renal cell carcinoma. On presentation, he was hyperpneic and laboratory analyses showed hyperglycemia and anion-gapped metabolic acidosis consistent with diabetic ketoacidosis. No other precipitating factors, besides nivolumab, were identified...
2018: Endocrinology, Diabetes & Metabolism Case Reports
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