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Somatosensory Evoked Potentials

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https://www.readbyqxmd.com/read/29154979/small-fiber-neuropathy-diagnosis-causes-and-treatment
#1
Damien Sène
Small fiber neuropathy, which affects the sensory A≏ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. To help achieve this goal, the present review article discusses the clinical presentation of neuropathic pain and paresthesia and/or autonomic dysfunction due to involvement of nerves supplying exocrine glands and smooth muscle; normal findings from standard electrophysiological investigations; most informative diagnostic tests (epidermal nerve fiber density in a skin biopsy, laser-evoked potentials, heat- and cold-detection thresholds, electrochemical skin conductance); main causes, which consist chiefly of metabolic diseases (diabetes mellitus, glucose intolerance), dysimmunity syndromes (Sjögren's syndrome, sarcoidosis, monoclonal gammopathy), and genetic abnormalities (familial amyloidosis due to a transthyretin mutation, Fabry disease, sodium channel diseases); and the available symptomatic and etiological treatments...
November 15, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29154918/attentional-modulation-of-somatosensory-processing-during-the-anticipation-of-movements-accompanying-pain-an-event-related-potential-study
#2
A Clauwaert, D M Torta, L Danneels, S Van Damme
Attending to pain-relevant information is crucial to protect us from physical harm. Behavioral studies have already suggested that during anticipation of pain somatosensory input at the body location under threat is prioritized. However, research using daily life cues for pain, especially movements, is lacking. Furthermore, no studies have looked at cortical processing associated with somatosensory processing during threatened movements. The current study aims to investigate whether movements accompanying pain automatically steer attention towards somatosensory input at the threatened location, affecting somatosensory evoked potentials...
November 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29146475/electrical-activity-of-sensory-pathways-in-female-and-male-geriatric-rhesus-monkeys-macaca-mulatta-and-its-relation-to-oxidative-stress
#3
A Ibáñez-Contreras, U Hernández-Arciga, A Poblano, M Arteaga-Silva, B Hernández-Godínez, G I Mendoza-Cuevas, R Toledo-Pérez, A Alarcón-Aguilar, V Y González-Puertos, M Konigsberg
Synapses loss during aging has been related to decreased neuronal excitability and reduced electrophysiological activity in the nervous system, as well as to increased brain damage. Those physiological and biochemical alterations have been related to the oxidative stress increase associated with old age. The main substrate of lipid peroxidation (LPX) in the central and peripheral nervous systems are the myelin sheaths, and their damage generates a delayed nerve conduction velocity. However, studies in which the neural conduction velocity is related to changes in the redox state are still lacking...
November 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29140922/fingolimod-reduces-neuropathic-pain-behaviors-in-a-mouse-model-of-multiple-sclerosis-by-a-sphingosine-1-phosphate-receptor-1-dependent-inhibition-of-central-sensitization-in-the-dorsal-horn
#4
Suzanne Doolen, Tommaso Iannitti, Benjamin C Shaw, Carolyn M Grachen, Renee R Donahue, Bradley K Taylor
Multiple sclerosis (MS) is an autoimmune-inflammatory neurodegenerative disease that is often accompanied by a debilitating neuropathic pain. Disease-modifying agents slow the progression of MS and prevent relapses, yet it remains unclear if they yield analgesia. We explored the analgesic potential of fingolimod (FTY720), an agonist/functional antagonist at the sphingosine-1-phosphate receptor 1 (S1PR1), because it reduces hyperalgesia in models of peripheral inflammatory and neuropathic pain. We used a myelin oligodendrocyte glycoprotein 35-55 (MOG35-55) mouse model of experimental autoimmune encephalomyelitis (EAE), modified to avoid frank paralysis and thus allow for assessment of withdrawal behaviors to somatosensory stimuli...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29138091/longitudinal-electrophysiological-changes-after-cervical-hemi-contusion-spinal-cord-injury-in-rats
#5
Zucheng Huang, Rong Li, Junhao Liu, Zhiping Huang, Yong Hu, Xiaoliang Wu, Qingan Zhu
OBJECTIVE: To evaluate the longitudinal somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) characterization from acute to chronic injury following cervical hemi-contusion spinal cord injury (SCI) in rats, and correlate the MEPs & SEPs to the behavioral outcomes. METHODS: Fifteen adult male Sprague-Dawley rats were subjected to the hemi-contusion spinal cord injury at C5. Forelimb MEPs & SEPs were applied to 5 animals before injury and 3h, 1d, 3d, 1w, 2w, 4w and 8w after injury respectively...
November 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29135702/relationship-between-sensory-dysfunction-and-walking-speed-in-patients-with-clinically-isolated-syndrome
#6
Magdalena Krbot Skorić, Luka Crnošija, Tereza Gabelić, Ivan Adamec, Mario Habek
PURPOSE: The aim of this study was to investigate a relationship between sensory dysfunction examined with somatosensory-evoked potentials of the posterior tibial nerve (tSSEP) and walking speed in patients with clinically isolated syndrome. METHODS: In 120 patients (mean age 32.2 ± 8.7 years, 84 females), Expanded Disability Status Scale (EDSS), timed 25-foot walk test (T25FW), brain and spinal cord MRI, and tSSEP were performed. P40 latencies and N22a-P40 interlatencies were analyzed, and the z-score for each latency was calculated and combined into total tSSEP z-score...
November 7, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29122298/evoked-potential-and-eeg-study-of-the-neurotoxicity-of-hydramethylnon-in-rats
#7
George M Strain
The objective of the study was to assess the neurotoxicity, using electrodiagnostic tests, of hydramethylnon (Amdro, AC 217,300), an insecticide marketed for the treatment of red imported fire ants, cockroaches, and other insects. Animals were male Fisher 344 albino rats and Long-Evans hooded rats. Brainstem auditory, visual, and somatosensory evoked potentials (BAER, VEP, SEP) and electroencephalograms (EEG) were recorded from implanted screw electrodes before and at multiple time points through day 10 after a single oral dose of hydramethylnon (at 50% or 75% of the LD50) plus vehicle, or vehicle alone...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29114283/a-method-for-reconstruction-of-severely-damaged-spinal-cord-using-autologous-hematopoietic-stem-cells-and-platelet-rich-protein-as-a-biological-scaffold
#8
Ahmed Sabry Ammar, Yasser Osman, Ahmed Taher Hendam, Mohammed Ahmed Hasen, Fatma Abdullah Al Rubaish, Danya Yaagoub Al Nujaidi, Faisal Mishal Al Abbas
Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in different centers, but none of which have reliably altered the outcome. Some trials use stem cells (SCs) that produced widely differing results. We hereby add our experience in our center of a surgical reconstruction of the damaged spinal cord using a mixture of SCs and Platelet-Rich Protein (PRP) with fibrin coated as a biological scaffold. Materials and Methods: Four cases of severely damaged spinal cord have been operated for neurolysis and reconstruction of the spinal cord using SCs and platelet-rich protein (PRP) with fibrin coated harvested from the peripheral circulation of the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29112509/association-between-sensorimotor-impairments-and-functional-brain-changes-in-patients-with-low-back-pain-a-critical-review
#9
Nina Goossens, Sofie Rummens, Lotte Janssens, Karen Caeyenberghs, Simon Brumagne
Low back pain (LBP) coincides with sensorimotor impairments, e.g., reduced lumbosacral tactile and proprioceptive acuity and postural control deficits. Recent functional magnetic resonance imaging (fMRI) studies suggest that sensorimotor impairments in LBP may be associated with brain changes. However, no consensus exists regarding the relationship between functional brain changes and sensorimotor behavior in LBP. Therefore, this review critically discusses the available fMRI studies on brain activation related to non-nociceptive somatosensory stimulation and motor performance in individuals with LBP...
November 6, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29094187/area-specific-processing-of-cerebellar-thalamo-cortical-information-in-primates
#10
Abdulraheem Nashef, Hannes Rapp, Martin P Nawrot, Yifat Prut
The cerebellar-thalamo-cortical (CTC) system plays a major role in controlling timing and coordination of voluntary movements. However, the functional impact of this system on motor cortical sites has not been documented in a systematic manner. We addressed this question by implanting a chronic stimulating electrode in the superior cerebellar peduncle (SCP) and recording evoked multiunit activity (MUA) and the local field potential (LFP) in the primary motor cortex ([Formula: see text]), the premotor cortex ([Formula: see text]) and the somatosensory cortex ([Formula: see text])...
November 2, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/29088953/somatosensory-evoked-potentials-in-patients-with-high-grade-aneurysmal-subarachnoid-hemorrhage
#11
Klaus Christian Mende, Mathias Gelderblom, Cindy Schwarz, Patrick Czorlich, Nils Ole Schmidt, Eik Vettorazzi, Jan Regelsberger, Manfred Westphal, Tammam Abboud
OBJECTIVE The aim of this prospective study was to investigate the value of somatosensory evoked potentials (SEPs) in predicting outcome in patients with high-grade aneurysmal subarachnoid hemorrhage (SAH). METHODS Between January 2013 and January 2015, 48 patients with high-grade SAH (Hunt and Hess Grade III, IV, or V) who were admitted within 3 days after hemorrhage were enrolled in the study. Right and left median and tibial nerve SEPs were recorded on Day 3 after hemorrhage and recorded again 2 weeks later...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29081426/bilateral-vestibulopathy-diagnostic-criteria-consensus-document-of-the-classification-committee-of-the-b%C3%A3-r%C3%A3-ny-society
#12
Michael Strupp, Ji-Soo Kim, Toshihisa Murofushi, Dominik Straumann, Joanna C Jen, Sally M Rosengren, Charles C Della Santina, Herman Kingma
This paper describes the diagnostic criteria for bilateral vestibulopathy (BVP) by the Classification Committee of the Bárány Society. The diagnosis of BVP is based on the patient history, bedside examination and laboratory evaluation. Bilateral vestibulopathy is a chronic vestibular syndrome which is characterized by unsteadiness when walking or standing, which worsen in darkness and/or on uneven ground, or during head motion. Additionally, patients may describe head or body movement-induced blurred vision or oscillopsia...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29074466/neuroprotective-assessment-of-prolonged-local-hypothermia-post-contusive-spinal-cord-injury-in-rodent-model
#13
Daniel Teh Boon Loong, Soo Min Chua, Ankshita Prasad, Ioannis Kakkos, Wenxuan Jiang, Yue Mu, Xiaogang Liu, Angelo Homayoun All
BACKGROUND CONTEXT: While general hypothermia is recognised as a clinically applicable neuroprotective intervention, acute moderate local hypothermia post-contusive Spinal Cord Injury (SCI) is being considered a more effective approach. Previously, we have investigated the feasibility and safety of inducing prolonged local hypothermia in the Central Nervous System of rodent model. PURPOSE: Here, we aimed to verify the efficacy and neuroprotective effects of 5 and 8 hours local moderate hypothermia (30±0...
October 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29063076/restless-legs-syndrome-secondary-to-pontine-infarction-clinical-analysis-of-five-cases
#14
Hou-Zhen Tuo, Ze-Long Tian, Yi-Nong Cui, Xiao-Yang Ma, Chun-Ling Xu, Hong-Yan Bi, Li-Yan Zhang, Yong-Bo Zhang, Wei-Dong Le, William Ondo
OBJECTIVE: Pontine infarction is a common type of stroke in the cerebral deep structures, resulting from occlusion of small penetrating arteries, may manifest as hemi-paralysis, hemi-sensory deficit, ataxia, vertigo, and bulbar dysfunction, but patients presenting with restless legs syndrome (RLS) are extremely rare. Herein, we reported five cases with RLS as a major manifestation of pontine infarction. METHODS: Five cases of pontine infarction related RLS were collected from July 2013 to February 2016...
September 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/29057523/aging-related-changes-in-the-cortical-processing-of-otolith-information-in-humans
#15
Peter Zu Eulenburg, Ria Maxine Ruehl, Pia Runge, Marianne Dieterich
Acoustic short tone bursts (STB) trigger ocular and cervical vestibular evoked myogenic potentials (oVEMPs/cVEMPs) by activating irregular otolith afferents. Simultaneously, STBs introduce an artificial net acceleration signal of otolith origin into the vestibular network. VEMP parameters as diagnostic otolith processing markers have been shown to decline after the age of thirty. To delineate the differential effects of healthy aging on the cortical vestibular subnetwork processing otolith information, we measured cVEMPs and the differential effects of unilateral STB in three age groups (20-40, 40-60, 60+; n=42) using functional neuroimaging...
October 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29055436/brain-white-matter-demyelinating-lesions-and-amyotrophic-lateral-sclerosis-in-a-patient-with-c9orf72-hexanucleotide-repeat-expansion
#16
Miguel Oliveira Santos, Inês Caldeira, Marta Gromicho, Ana Pronto-Laborinho, Mamede de Carvalho
A hexanucleotide repeat expansion in the C9orf72 gene is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. It has been described before four patients with multiple sclerosis (MS) and C9orf72-ALS. However, C9orf72 positivity is not associated with increased risk of MS. Inflammatory pathways related to NF-κB have been linked to ALS and MS, and appear to be important in C9orf72-ALS patients. A 42-year-old woman presented with progressive bulbar symptoms for 9 months. Neurological examination disclosed spastic dysarthria, atrophic tongue with fasciculations, brisk jaw and limb tendon reflexes, and bilateral Hoffman sign...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29050394/cortical-neurons-and-networks-are-dormant-but-fully-responsive-during-isoelectric-brain-state
#17
Tristan Altwegg-Boussac, Adrien E Schramm, Jimena Ballestero, Fanny Grosselin, Mario Chavez, Sarah Lecas, Michel Baulac, Lionel Naccache, Sophie Demeret, Vincent Navarro, Séverine Mahon, Stéphane Charpier
A continuous isoelectric electroencephalogram reflects an interruption of endogenously-generated activity in cortical networks and systematically results in a complete dissolution of conscious processes. This electro-cerebral inactivity occurs during various brain disorders, including hypothermia, drug intoxication, long-lasting anoxia and brain trauma. It can also be induced in a therapeutic context, following the administration of high doses of barbiturate-derived compounds, to interrupt a hyper-refractory status epilepticus...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29049087/raising-mean-arterial-pressure-alone-restores-20-of-intraoperative-neuromonitoring-losses
#18
Joshua Yang, David L Skaggs, Priscella Chan, Suken A Shah, Michael G Vitale, Geraldine Neiss, Nicholas Feinberg, Lindsay M Andras
STUDY DESIGN: Multicenter prospective. OBJECTIVE: To assess the effect of intraoperative interventions in restoring intraoperative neuromonitoring (IONM) signals in pediatric spine surgery. SUMMARY OF BACKGROUND DATA: No prior studies have prospectively examined the rate of return of IONM signals by increasing blood pressure (BP) alone. METHODS: Patients undergoing posterior spinal deformity surgery were enrolled at their preoperative appointment...
October 18, 2017: Spine
https://www.readbyqxmd.com/read/29042004/quantitative-functional-mri-and-neurophysiological-markers-in-a-case-of-gerstmann-str%C3%A3-ussler-scheinker-syndrome
#19
Silvia Marino, Rosa Morabito, S De Salvo, L Bonanno, A Bramanti, P Pollicino, R Giorgianni, Placido Bramanti
Gerstmann-Sträussler-Scheinker syndrome (GSS) is an inherited autosomal dominant prion disease, caused by a codon 102 proline to leucine substitution (P102L) in the prion protein gene (PRNP). We describe the case of a 40-year-old male, affected by a slowly progressive gait disturbance, leg weakness and cognitive impairment. Genomic DNA revealed a point mutation of PRNP at codon 102, resulting in P102L, and the diagnosis of GSS was confirmed. Somatosensory evoked potentials showed alterations of principal parameters, particularly in the right upper and lower limbs...
July 2017: Functional Neurology
https://www.readbyqxmd.com/read/29038847/touching-lips-and-hearing-fingers-effector-specific-congruency-between-tactile-and-auditory-stimulation-modulates-n1-amplitude-and-alpha-desynchronization
#20
Guannan Shen, Andrew N Meltzoff, Peter J Marshall
Understanding the interactions between audition and sensorimotor processes is of theoretical importance, particularly in relation to speech processing. Although one current focus in this area is on interactions between auditory perception and the motor system, there has been less research on connections between the auditory and somatosensory modalities. The current study takes a novel approach to this omission by examining specific auditory-tactile interactions in the context of speech and non-speech sound production...
October 16, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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