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Esma Akpınar, Cem Cerit, Anıl Talas, Ümit Tural
Objective: In this open-labeled, 12 weeks follow-up study, we aimed to compare the efficacy and tolerability of agomelatine with sertraline. Methods: The outpatients of adult psychiatry clinic who have a new onset of depression and diagnosed as 'major depressive episode' by clinician according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition and prescribed agomelatine (25 mg/day) or sertraline (50 mg/day) were included in the study. Results: The decline of mean Montgomery-Asberg Depression Rating Scale (MADRS) scores of agomelatine group was significantly higher than the sertraline group at the end of 2nd week; however, the difference was not significant at the end of 3 months...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Mei Chung, Alice M Tang, Zhuxuan Fu, Ding Ding Wang, Sydne Jennifer Newberry
Background: Conflicting evidence exists regarding potential cardiovascular risks associated with high levels of calcium intake. Purpose: To update and reanalyze 2 systematic reviews to examine the effects of calcium intake on cardiovascular disease (CVD) among generally healthy adults. Data Sources: MEDLINE; Cochrane Central Register of Controlled Trials; Scopus, including EMBASE; and previous evidence reports from English-language publications from 1966 to July 2016...
October 25, 2016: Annals of Internal Medicine
Rumi Hisakata, Daisuke Hayashi, Ikuya Murakami
The static envelope of a Gabor patch with a moving sinusoidal carrier appears shifted in the direction of the carrier motion (De Valois & De Valois, 1991). This phenomenon is called motion-induced position shift. Although several motion-processing stages, ranging from low- to high-level processes, may contribute to position estimation, it is unknown whether a binocular matching stage or an even earlier stage exerts an influence. To elucidate this matter, we investigated the disparity tuning of this illusion by manipulating the binocular disparities of the carrier and the envelope...
October 1, 2016: Journal of Vision
Sinead Toomey, Stephen F Madden, Simon J Furney, Yue Fan, Mark McCormack, Carragh Stapleton, Mattia Cremona, Gianpiero L Cavalleri, Malgorzata Milewska, Naomi Elster, Aoife Carr, Joanna Fay, Elaine W Kay, Susan Kennedy, John Crown, William M Gallagher, Bryan T Hennessy, Alex J Eustace
BACKGROUND: Trastuzumab treatment for women with HER2-positive breast cancer (BC) resulted in the significant improvement of both relapse free survival (RFS) and overall survival (OS). However, many women who are classified as HER2-positive do not respond. Many studies have focused on the role of somatic mutations rather than germline polymorphisms in trastuzumab resistance. RESULTS: We completed an Agena MassArray screen of 10 ERBB-family single nucleotide polymorphisms (SNPs) in 194 adjuvant trastuzumab treated HER2-positive BC patients...
October 20, 2016: Oncotarget
Hannah M Gustafson, Peter A Cripton, Stephen J Ferguson, Benedikt Helgason
The purpose of this study was to load cadaveric vertebral bodies (n=6) in compression and compare the response, measured with digital image correlation (DIC) on the cortex, with the predicted response from specimen-specific vertebral finite element (FE) models. Five modulus-density relationships were evaluated, and for the strongest modulus-density relationship, the correlation between the DIC and FE displacements had R(2) values from 0.75 to 0.93. The stiffnesses derived from the DIC measurements were strongly predicted by the FE stiffnesses (R(2)=0...
October 7, 2016: Journal of the Mechanical Behavior of Biomedical Materials
S Chauhan, K Manoj, S Rastogi, S A Khan, A Prasad
Extra Corporeal irradiation and Reimplantation Therapy (ECRT) is an established biological reconstruction technique of limb salvage surgery for malignant bone tumor. Several studies have focused on clinical outcome of the procedure, but biomechanical changes post ECRT procedure are not well established. The present study investigates changes in strength, deformation, and composition of cortical bone obtained post en block resection from five patients suffering from ECRT, and the results are verified against age-match control specimen from cadaver...
October 4, 2016: Journal of the Mechanical Behavior of Biomedical Materials
S C Cifuentes, E Frutos, R Benavente, V Lorenzo, J L González-Carrasco
This work deals with the mechanical characterization by depth-sensing indentation (DSI) of PLLA and PLDA composites reinforced with micro-particles of Mg (up to 15wt%), which is a challenging task since the indented volume must provide information of the bulk composite, i.e. contain enough reinforcement particles. The composites were fabricated by combining hot extrusion and compression moulding. Physico-chemical characterization by TGA and DSC indicates that Mg anticipates the thermal degradation of the polymers but does not compromise their stability during processing...
September 21, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Varsha B Gujar, Divya Ottoor
Behavior of Amiloride (AMI) as a metal ion sensor in anionic surfactant assemblies of varying concentrations at different pH is depicted in this work. From a non-sensor fluorophore, AMI has been transformed in to a tunable fluorosensor for Cu(2+) ions in various SDS concentrations. At premicellar concentration of SDS, ion-pair complex is expected to be formed between AMI and SDS due to electrostatic interactions between them. However at CMC concentrations of SDS, fluorescence intensity of AMI is greatly enhanced with red shift in emission, due to the incorporation of AMI molecule in the hydrophobic micellar interface...
October 18, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Tianqi Liu, Xuejuan Wan, Yunsheng Dong, Weibin Li, Lisi Wu, Hang Pei, Youwei Yao
In this study, a facile water-soluble fluorescence sensor 2-((2-hydroxybenzylidene)-amino)-2-(hydroxymethyl)propane-1,3-diol (ST) was synthesized via one-step reaction, and its fluorescence sensing performance for Al(3+) both in aqueous solution and on paper substrate was evaluated. The results showed that ST exhibited an specific fluorescence "turn-on" response to Al(3+) over other cations in aqueous solution as well as on the test paper. The limit of detection was found to be 3.2×10(-7)M, which revealed that the obtained Schiff-base based fluorescence chemosensor ST possessed a great potential for the rapid, quantitative and qualitative detection of Al(3+)...
October 11, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
A C Sampaio, R J Mendes, P G Castro, A M Silva
Solid lipid nanoparticles (SLNs) are used as carriers for drug delivery, and are high biocompatible and designed to endure in the host organism. Despite its current industrial production is low, many of these substances are available on the market, and much more are in the production pipeline. As a result, many of them will end in aquatic systems raising the question whether they can pose a risk to aquatic biota and the associated ecological processes. Microbial decomposers of plant litter, play a key role in forested streams being responsible for the energy flow between terrestrial and aquatic environments...
October 21, 2016: Ecotoxicology and Environmental Safety
Laura Jenkins, Jeremy Cosgrove, Paul Chappell, Ammar Kheder, Dilraj Sokhi, Markus Reuber
The diagnostic distinction between epilepsy and psychogenic nonepileptic seizures (PNES) can be challenging. Previous studies have demonstrated that experts in conversation analysis can identify linguistic and interactional features in transcripts and recordings of interviews with patients that reliably distinguish between epilepsy and PNES. In this study, ten senior neurology trainees took part in a one-day intervention workshop about linguistic and interactional differences in the conversation behavior of patients with epilepsy and those with PNES...
October 21, 2016: Epilepsy & Behavior: E&B
M Mezzelani, S Gorbi, D Fattorini, G d'Errico, M Benedetti, M Milan, L Bargelloni, F Regoli
The aim of the present investigation was to provide new insights on accumulation and possible adverse effects of various non-steroidal anti-inflammatory drugs (NSAIDs) in mussels, Mytilus galloprovincialis, exposed to an environmentally realistic concentration (0.5μg/L) of individual compounds, Acetaminophen (AMP), Diclofenac (DIC), Ibuprofen (IBU), Ketoprofen (KET) or Nimesulide (NIM). The measurement of drugs in mussel tissues was integrated with both functional alterations at cellular level and transcriptomic responses...
October 11, 2016: Aquatic Toxicology
Shaw D Bamber, Stig Westerlund
Sub-sea geological storage of carbon dioxide (CO2) provides a viable option for the Carbon Capture and Storage (CCS) approach for reducing atmospheric emissions of this greenhouse gas. Although generally considered to offer a low risk of major leakage, it remains relevant to establish the possible consequences for marine organisms that live in or on sediments overlying these storage areas if such an event may occur. The present study has used a series of laboratory exposures and behavioral bioassays to establish the sensitivity of Arctica islandica to simulated leakages of CO2...
October 11, 2016: Aquatic Toxicology
Hongru Yang, Jian Tian, Yanyan Bo, Yanli Zhou, Xinzhen Wang, Hongzhi Cui
Novel In2O3 nanoparticle/TiO2 nanobelt heterostructures with enhanced visible-light photocatalytic and photoelectrochemical (PEC) performance were successfully prepared via a facile hydrothermal method. Well-dispersed In2O3 nanoparticles with small sizes are uniformly attached on the surface of TiO2 nanobelts to form In2O3 nanoparticle/TiO2 nanobelt heterostructures. The TiO2 nanobelts as backbones restrict the aggregation of In2O3 nanoparticles, resulting in the formation of smaller In2O3 nanoparticles with more interaction sites for pollutants...
October 20, 2016: Journal of Colloid and Interface Science
Hanaa Alkharobi, Aishah Alhodhodi, Yousef Hawsawi, Hasanain Alkafaji, Deirdre Devine, Reem El-Gendy, James Beattie
Human dental pulp cells (DPCs), which are known to contain a subset of stem cells capable of reforming a dentin and pulp-like complex upon in vivo transplantation, were isolated from third molars of three healthy donors and differentiated to a matrix mineralisation phenotype using by culture in dexamethasone and l-ascorbic acid. qRT-PCR analysis of insulin-like growth factor ( IGF) axis gene expression indicated that all genes, except insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein-1 ( IGFBP-1), were expressed in DPCs...
September 24, 2016: Stem Cell Research
Patrizia Carità, Egle Corrado, Gianluca Pontone, Antonio Curnis, Luca Bontempi, Giuseppina Novo, Marco Guglielmo, Gianfranco Ciaramitaro, Pasquale Assennato, Salvatore Novo, Giuseppe Coppola
BACKGROUND: Cardiac resynchronization therapy (CRT) is a successful strategy for heart failure (HF) patients. The pre-requisite for the response is the evidence of electrical dyssynchrony on the surface electrocardiogram usually as left bundle branch block (LBBB). Non-response to CRT is a significant problem in clinical practice. Patient selection, inadequate delivery and sub-optimal left ventricle lead position may be important causes. OBJECTIVES: In an effort to improve CRT response multimodality imaging (especially echocardiography, computed tomography and cardiac magnetic resonance) could play a decisive role and extensive literature has been published on the matter...
September 17, 2016: International Journal of Cardiology
Lingling Li, Da Yang, Yufang Song, Yi Shi, Bin Huang, Jun Yan, Xinxin Dong
In this study, toxic effects of bifenthrin in soil on earthworms were evaluated by acute and chronic toxic endpoints combined with a set of biomarkers. Bifenthrin was moderately toxic in 72-h filter paper test and low toxic in 14-d soil test. The exposure of earthworms to bifenthrin-polluted soil for 8 weeks showed that cocoons were inhibited by high dose of bifenthrin, and larvae were stimulated by low dose but inhibited by high dose of bifenthrin. Furthermore, 28-d soil test on the responses of enzymes associated with antioxidation and detoxification in worms showed that peroxidase (POD) was stimulated by bifenthrin, superoxide dismutase (SOD) inhibited in the early period but stimulated in the later period, glutathione S- transferase (GST) inhibited in the later period, and ethoxyresorufin-O-deethylase (EROD) inhibited at day 3 but markedly stimulated at day 28 at high dose...
October 21, 2016: Chemosphere
Jun Shi, Huiping Deng, Huichao Pan, Yinjie Xu, Min Zhang
Epigallocatechin-3-gallate (EGCG) has been shown to possess anti-inflammatory effects. Microcystin-LR (MC-LR) is a potent toxin and our past research suggested that it also mediated human umbilical vein endothelial cell (HUVEC) injury. The aim of this study was to investigate the effects of EGCG on MC-LR-induced oxidative stress and inflammatory responses in HUVECs. HUVECs were stimulated with MC-LR in the presence or absence of EGCG. MC-LR (40 μM) significantly increased cell death and decreased cell viability, migration, and tube formation, whereas EGCG (50 μM) inhibited these effects...
October 21, 2016: Chemosphere
Florian Matt, Tom Cole-Hunter, David Donaire-Gonzalez, Nadine Kubesch, David Martínez, Glòria Carrasco-Turigas, Mark Nieuwenhuijsen
BACKGROUND: Physical activity (PA) has beneficial, whereas exposure to traffic related air pollution (TRAP) has adverse, respiratory effects. Few studies, however, have examined if the acute effects of TRAP upon respiratory outcomes are modified depending on the level of PA. OBJECTIVES: The aim of our study was to disentangle acute effects of TRAP and PA upon respiratory outcomes and assess the impact of participants TRAP pre-exposure. METHODS: We conducted a real-world crossover study with repeated measures of 30 healthy adults...
October 20, 2016: Environment International
Qi Zhang, Zhongduo Wang, Feng Hou, Rachel Harding, Xinyi Huang, Aiping Dong, John R Walker, Yufeng Tong
BACKGROUND: Seven in absentia homologs (SIAHs) comprise a family of highly conserved E3 ubiquitin ligases that play an important role in regulating signalling pathways in tumorigenesis, including the DNA damage repair and hypoxia response pathways. SIAH1 and SIAH2 have been found to function as a tumour repressor and a proto-oncogene, respectively, despite the high sequence identity of their substrate binding domains (SBDs). Ubiquitin-specific protease USP19 is a deubiquitinase that forms a complex with SIAHs and counteracts the ligase function...
October 21, 2016: Biochimica et Biophysica Acta
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