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Hong Ruan, Youcheng Yu, Xuehua Guo, Qian Jiang, Ying Luo
Background: In this study, simvastatin (SVT) in situ gels were successfully produced by our group. Methods: The preparations were characterized in the following aspects: in vitro gelation, drug release, stability and pharmacodynamics. Results: In this study, drug content of prepared gels was found to be in the range between 89 and 92%. The pH value was in the range between 6.5 and 7.0. The gelation temperature of the prepared thermogelling solutions was 37°C...
2018: Drug Design, Development and Therapy
Imane El Hajjaji, Giuliano Becker, Teresa Kus, Alain Vinet, Artur Berkovitz, Marcio Sturmer
BACKGROUND: Many diagnostic criteria for the differential diagnosis of wide complex tachycardia (WCT) are complex and not completely accurate. Incorrect diagnosis is also related to error in applying criteria. OBJECTIVES: To propose a novel reliable criterion for wide QRS complexes' differential diagnosis. MATERIAL AND METHODS: One hundred Electrocardiograms (ECGs) with wide QRS complexes were analyzed using the ECG software. Five variables were measured during the first 20 ms of QRS in leads V1 and V2 and compared between premature ventricular contraction (PVC) and conducted supraventricular impulse with bundle branch block (BBB) groups...
July 2018: Journal of Electrocardiology
Georgy Kaspar, Kumar Sanam, Sujana Gundlapalli, Dipak Shah
Even in the absence of underlying heart disease, pregnancy is known to increase susceptibility supraventricular tachycardia (SVT). This brings a management challenge, mainly due to concerns about pharmacotherapy and radiation to the fetus. This case highlights the capability of using fluoroless mapping technologies to treat refractory arrhythmia cases safely and successful.
July 2018: Clinical Case Reports
Barbara A DeBurger, Sarah Hanna, Joel E Mortensen
Total-Fix, Cary-Blair, and Para-Pak SVT parasite transport systems were compared to 10% formalin with the BD MAX Enteric Parasite Panel, using clinical and contrived samples to determine comparability and limits of detection. The three transport systems have equal or superior limits of detection for all pathogens tested compared to 10% formalin.
June 12, 2018: Diagnostic Microbiology and Infectious Disease
Michele Bertoni, Alessandro Squizzato, Marina Foretic, Samanta Zanieri, Massimo Edoardo Di Natale
INTRODUCTION: Venous thromboembolic events (VTE) occur in more than 5% of hospitalized patients with acute CMV infection. In immunocompetent patients, splanchnic vein thrombosis (SVT) and splenic infarction have been suggested to represent approximately half of the published cases of CMV-associated VTE. We performed a systematic review of the literature with the aim to describe epidemiology, clinical characteristics, treatment, and natural history of CMV-associated SVT in immunocompetent patients...
June 21, 2018: Thrombosis Research
Laura Esther Huhnd, Stefan P Wirtz, Thomas Schrom
OBJECTIVE: A tube dysfunction is a common medical issue and can promote chronic otitis media. With the implementation of the Balloon dilation a treatment of the chronic tube dysfunction was set. In the present study significance of this method was assessed, especially questioning the success in practical terms of tympanic membrane retraction. MATERIAL AND METHODS: In a retrospective study, in a period of assessment from 2011 until 2016, the data of 81 patients, who underwent Balloon dilation of the Eustachian tube due to chronic tube dysfunction with regard to a preoperative presence of tympanic membrane retraction were evaluated...
June 28, 2018: Laryngo- Rhino- Otologie
Jae-Sun Uhm, Jong-Il Choi, Yong Soo Baek, Hee Tae Yu, Pil-Sung Yang, Yun Gi Kim, Suk-Kyu Oh, Hee-Soon Park, Kwang No Lee, Tae-Hoon Kim, Jaemin Shim, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee, Young-Hoon Kim
BACKGROUND: The electrophysiological features and roles of persistent left superior vena cava (PLSVC) in supraventricular tachycardia (SVT) are not known. OBJECTIVE: To elucidate the electrophysiological features and roles of PLSVC in patients with SVT. METHODS: We included 37 patients (age: 43.5 ± 17.1 years; men: 35.1%) with PLSVC and 510 patients (age: 43.9 ± 18.8 years; men: 48.2%) without PLSVC who underwent an electrophysiological study for SVT...
June 25, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Guido Finazzi, Valerio De Stefano, Tiziano Barbui
Myeloproliferative neoplasms (MPNs) are a leading cause of splanchnic vein thrombosis (SVT). SVT is observed in all MPNs and frequently affects young patients. Therapy should be addressed to three main goals: preventing thrombosis recurrence, managing the underlying MPN, and supporting liver dysfunction. Life-long oral anticoagulation with vitamin K antagonists is the cornerstone of the antithrombotic treatment. However, recurrences of SVT or other thrombosis may occur in 15-20% of patients. Direct oral anticoagulants can represent an alternative and preliminary data encourage comparative studies...
June 26, 2018: Blood Cancer Journal
Jessica J Voerman, Mary E Hoffe, Sam Surka, Paulo M Alves
BACKGROUND: Supraventricular tachycardia (SVT) is a common presenting arrhythmia in the general population. Cases of SVT presenting during commercial air travel are always challenging as they might be confused with other conditions requiring different treatment strategies. We present a case of an in-flight SVT that was successfully managed using telemedicine support. CASE REPORT: A 33-yr-old woman developed chest pain and dizziness while on an international commercial flight...
July 1, 2018: Aerospace Medicine and Human Performance
Muhammad U Butt, Ripa Patel, Yousef H Darrat, Gustavo X Morales, Claude S Elayi
BACKGROUND Wolff-Parkinson-White (WPW) pattern is due to a pre-excitation leading to characteristic ECG changes in sinus rhythm as short PR interval, the presence of delta waves, wide QRS complexes, and potentially Q wave-T wave vector discordance (pseudo-infarct pattern). These later changes can mask the underlying ECG depolarizing solely through the His-Purkinje system. Our case highlights how the ECG of a WPW pattern with a pseudo-infarct pattern can in fact mask a true infarct on the underlying ECG without pre-excitation...
June 13, 2018: American Journal of Case Reports
Caineng Wu, Wuhua Ma, Qingyun Cen, Qingxiang Cai, Jiyong Wang, Ying Cao
BACKGROUND: Postoperative supraventricular arrhythmias are common in patients after thoracoscopic lobectomy. Inadequate pain control has long been recognised as a significant risk factor for arrhythmias. The performance of ultrasound-guided (USG) thoracic paravertebral block (PVB) is increasing as an ideal technique for postoperative analgesia. OBJECTIVE: We conducted this study to evaluate whether a single-shot USG thoracic PVB would result in fewer postoperative supraventricular tachycardias (SVT) than intercostal nerve blocks (ICNBs) after thoracoscopic pulmonary resection...
May 29, 2018: European Journal of Anaesthesiology
Miaomiao Li, Valerio De Stefano, Tingxue Song, Xinmiao Zhou, Zeqi Guo, Jia Zhu, Xingshun Qi
BACKGROUND: The prevalence of calreticulin (CALR) mutations in splanchnic vein thrombosis (SVT) varies among studies. The role of routine screening for CALR mutations in SVT patients remains a debate. AIM: To synthesize the prevalence of CALR mutations according to the different types (i.e., Budd-Chiari syndrome [BCS] and portal vein thrombosis [PVT]) and characteristics (i.e., with and without myeloproliferative neoplasms [MPNs] and JAK2V617F mutation) of SVT patients...
May 8, 2018: Thrombosis Research
Jean-Philippe Galanaud, Sophie Blaise, Marie-Antoinette Sevestre, Hugo Terrisse, Gilles Pernod, Catherine Gaillard, Celine Genty, Manuel Monreal, Yacine Rabah, Susan R Kahn, Isabelle Quéré, Jean-Luc Bosson
BACKGROUND: Cancer patients who develop a deep-vein thrombosis (DVT) or a pulmonary embolism (PE) are at higher risk of death than similar cancer patients who do not develop DVT or PE. The impact of isolated superficial venous thrombosis (SVT) (i.e. without DVT or PE) on the prognosis of cancer patients is unknown. METHODS: Data from the OPTIMEV, multicentre, observational study, to compare at 3 years the incidences of death, DVT-PE recurrence and bleeding of cancer patients with objectively confirmed SVT vs...
April 20, 2018: Thrombosis Research
David Noorvash, Rosemarie Ramos, Linda Hatch, Andrew Muck, Adriana Segura Olson
BACKGROUND: A troponin assay is commonly sent for patients presenting to emergency departments (EDs) with supraventricular tachycardia (SVT). Multiple studies suggest that elevated troponin levels do not predict coronary artery disease in these patients. Patients with elevated troponins are more likely to have additional cardiac testing, which can lead to increased health care costs and unnecessary invasive procedures. OBJECTIVE: Our objective was to evaluate low- to intermediate-risk patients (HEART [history, electrocardiography, age, risk factors and troponin] Score 1-6) presenting to the ED with SVT...
July 2018: Journal of Emergency Medicine
Seon-Mi Yu, Song Ja Kim
Simvastatin is a cholesterol-lowing reagent that is derived synthetically from the fermentation of Aspergillus terreus. Recently, SVT has been shown to possess a protective effect of chondrocytes. Kruppel-like factor 4 (KLF-4) is a zinc finger transcription factor that plays crucial roles during the development and maintenance of multiple organs. However, the roles of KLF-4 in chondrocytes have not been well unknown. Here, we investigated whether KLF-4 regulates SVT-caused differentiated phenotype of chondrocytes...
June 27, 2018: Biochemical and Biophysical Research Communications
Sylva Lajzová, Radek Kroupa, Alena Buliková, Šárka Bohatá, Barbora Packová, Michal Šenkyřík
Splanchnic vein thrombosis (SVT) represents an unusual manifestation of venous thromboembolism. The etiological factors for SVT can be divided into local and systemic, frequently found concurrently. SVT can be the first presenting symptom in myeloproliferative neoplasms. SVT puts the patients affected in jeopardy of developing the intestinal infarction, impairing the liver function and portal hypertension development with the risk of potentially life-threatening gastrointestinal bleeding. The current guidelines emphasise the role of anticoagulation in acute splanchnic thrombosis...
2018: Vnitr̆ní Lékar̆ství
Henrike Siebels, Christian Sohns, Jan-Hendrik Nürnberg, Jürgen Siebels, Klaus Langes, Joachim Hebe
PURPOSE: Radiofrequency current energy (RFC) ablation is still considered as the gold standard for atrioventricular nodal reentrant tachycardia (AVNRT). Success-rates for AVNRT ablation vary irrespective of the ablation technology and strategy. This study aimed to access safety, efficacy, and long-term outcome of RFC catheter ablation for the treatment of AVNRT in children and adolescents aged < 19 years with special focus on modulation versus ablation of the AV nodal slow pathway (SP)...
May 15, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Mitsunori Maruyama, Shunsuke Uetake, Yasushi Miyauchi, Yoshihiko Seino, Wataru Shimizu
OBJECTIVES: The goal of this study was to determine the diagnostic yield of analyzing the mode of termination during ventricular overdrive pacing (VOP) to differentiate the mechanisms of supraventricular tachycardias (SVTs). BACKGROUND: The majority of the diagnostic criteria for VOP rely on successful entrainment, but termination of SVTs is common during VOP. METHODS: We studied 225 SVTs with a 1:1 atrioventricular relationship, including 34 atrial tachycardias, 67 orthodromic reciprocating tachycardias (ORTs) (including 4 ORTs using accessory pathways [APs] with decremental properties), and 124 atrioventricular nodal re-entrant tachycardias...
November 2017: JACC. Clinical Electrophysiology
Anil V Yadav, Babak Nazer, Barbara J Drew, John M Miller, Hicham El Masry, William J Groh, Andrea Natale, Nassir Marrouche, Nitish Badhwar, Yanfei Yang, Melvin M Scheinman
OBJECTIVES: This study sought to determine the ability of conventional electrocardiographic (ECG) criteria to correctly differentiate idiopathic ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy. BACKGROUND: Previously reported VT ECG criteria were developed from cohorts of patients with structural heart disease and have not been applied to patients with idiopathic VT. METHODS: ECGs of 115 idiopathic VTs, 101 post-myocardial infarction (MI) VTs, and 111 wide QRS SVTs were analyzed using standard criteria...
July 2017: JACC. Clinical Electrophysiology
I Novitzky-Basso, F Spring, D Anstee, D Tripathi, F Chen
INTRODUCTION: Lutheran/BCAM protein (Lu) on the surface of erythrocytes is key for their adhesion to the endothelium, and erythrocytes from individuals with JAK2V617F-mutated myeloproliferative neoplasms (MPN) have increased endothelial adhesion. Splanchnic vein thrombosis (SVT) is a devastating thrombotic complication of MPN, and frequently, the only diagnostic feature is the JAK2V617F mutation. We sought to examine whether erythrocytes from patients with JAK2V617F mutated SVT (MPN-SVT) exhibited increased Lu expression, thereby supporting a mechanistic contribution to the development of thrombosis...
May 13, 2018: International Journal of Laboratory Hematology
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