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https://www.readbyqxmd.com/read/28453304/mold-allergy-is-it-real-and-what-do-we-do-about-it
#1
Amanda Rudert, Jay Portnoy
Fungi produce substances that contain pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) which bind to pattern recognition receptors, stimulating innate immune responses in humans. They also produce allergens that induce production of specific IgE. Areas Covered: In this review we cover both innate and adaptive immune responses to fungi. Some fungal products can activate both innate and adaptive responses and in doing so, cause an intense and complex health effects...
April 28, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28453278/hydrophobization-of-silica-nanoparticles-in-water-nanostructure-and-response-to-drying-stress
#2
Solenn Moro, Caroline Parneix, Bernard Cabane, Nicolas Sanson, Jean-Baptiste d'Espinose de Lacaillerie
In this paper, we investigated the impact of surface hydrophobization on the structure of aqueous silica suspension and how this structure resists drying stress. To achieve this, hydrophilic silica particles were hydrophobized directly in water using different organosilane precursors, with a precise control of the grafting density. The resulting nanostructure was precisely analyzed by a combination of small angle X-ray scattering (SAXS) and cryo-microscopy (cryo-TEM). Then, the suspension was progressively concentrated by drying to follow by SAXS the evolution of the nanostructures as a function of the grafting density...
April 28, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28446773/therapeutic-effects-of-anti-hmgb1-monoclonal-antibody-on-pilocarpine-induced-status-epilepticus-in-mice
#3
Li Fu, Keyue Liu, Hidenori Wake, Kiyoshi Teshigawara, Tadashi Yoshino, Hideo Takahashi, Shuji Mori, Masahiro Nishibori
Inflammatory processes in brain tissue have been described in human epilepsy of various etiologies and in experimental models of seizures. High mobility group box-1 (HMGB1) is now recognized as representative of damage-associated molecular patterns (DAMPs). In the present study, we focused on whether anti-HMGB1 antibody treatment could relieve status epilepticus- triggered BBB breakdown and inflammation response in addition to the seizure behavior itself. Pilocarpine and methyl-scopolamine were used to establish the acute seizure model...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28444590/transcripts-of-pectin-degrading-enzymes-and-isolation-of-complete-cdna-sequence-of-a-pectate-lyase-gene-induced-by-coffee-white-stem-borer-xylotrechus-quadripes-in-the-bark-tissue-of-coffea-canephora-robusta-coffee
#4
Kosaraju Bharathi, P Santosh, H L Sreenath
Of the two commercially cultivated coffee (Coffea) species, C. arabica (arabica) is highly susceptible and C. canephora (robusta) is highly resistant to the insect pest Xylotrechus quadripes (Coleoptera: Cerambycidae), commonly known as coffee white stem borer (CWSB). We constructed a forward-subtracted cDNA library by Suppression Subtractive Hybridization (SSH) from robusta bark tissue for profiling genes induced by CWSB infestation. Among the 265 unigenes of the SSH EST library, 7 unigenes (5 contigs and 2 singletons) matching different pectin-degrading enzymes were discovered...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28443680/periodic-breathing-during-incremental-exercise
#5
Piergiuseppe Agostoni, Ugo Corrà, Michele Emdin
Periodic breathing during incremental cardiopulmonary exercise testing is a regularly recurring waxing and waning of tidal volume due to oscillations in central respiratory drive. Periodic breathing is a sign of respiratory control system instability, which may occur at rest or during exercise. The possible mechanisms responsible of exertional periodic breathing might be related to any instability of the ventilatory regulation caused by: 1) increased circulatory delay (i.e., circulation time from the lung to the brain and chemoreceptors, due to reduced cardiac index leading to delay in information transfer), 2) increase in controller gain (i...
April 26, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28443647/identifying-and-modeling-the-structural-discontinuities-of-human-interactions
#6
Sebastian Grauwin, Michael Szell, Stanislav Sobolevsky, Philipp Hövel, Filippo Simini, Maarten Vanhoof, Zbigniew Smoreda, Albert-László Barabási, Carlo Ratti
The idea of a hierarchical spatial organization of society lies at the core of seminal theories in human geography that have strongly influenced our understanding of social organization. Along the same line, the recent availability of large-scale human mobility and communication data has offered novel quantitative insights hinting at a strong geographical confinement of human interactions within neighboring regions, extending to local levels within countries. However, models of human interaction largely ignore this effect...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440700/selection-and-assessment-of-plant-growth-promoting-rhizobacteria-pgpr-for-biological-control-of-multiple-plant-diseases
#7
Ke Liu, Molli Newman, John A McInroy, Chia-Hui Hu, Joseph W Kloepper
A study was designed to screen individual strains of plant growth-promoting rhizobacteria (PGPR) for broad-spectrum disease suppression in vitro and in planta. In a preliminary screen, 28 of 196 strains inhibited eight different tested pathogens in vitro. In a secondary screen, these 28 strains showed broad spectrum antagonistic activity to six different genera of pathogens, and 24 of the 28 strains produced five traits reported to be related to plant growth promotion, including nitrogen fixation, phosphate solubilization, indole-3-acetic acid (IAA) production, siderophore production, and biofilm formation...
April 25, 2017: Phytopathology
https://www.readbyqxmd.com/read/28439562/anomalous-spin-orbit-torque-switching-due-to-field-like-torque-assisted-domain-wall-reflection
#8
Jungbum Yoon, Seo-Won Lee, Jae Hyun Kwon, Jong Min Lee, Jaesung Son, Xuepeng Qiu, Kyung-Jin Lee, Hyunsoo Yang
Spin-orbit torques (SOTs) allow the electrical control of magnetic states. Current-induced SOT switching of the perpendicular magnetization is of particular technological importance. The SOT consists of damping-like and field-like torques, and understanding the combined effects of these two torque components is required for efficient SOT switching. Previous quasi-static measurements have reported an increased switching probability with the width of current pulses, as predicted considering the damping-like torque alone...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28438613/stress-altered-synaptic-plasticity-and-damp-signaling-in-the-hippocampus-pfc-axis-elucidating-the-significance-of-igf-1-igf-1r-camkii%C3%AE-expression-in-neural-changes-associated-with-a-prolonged-exposure-therapy
#9
Olalekan M Ogundele, Philip J Ebenezer, Charles C Lee, Joseph Francis
Traumatic stress patients showed significant improvement in behavior after a prolonged exposure to an unrelated stimulus. This treatment method attempts to promote extinction of the fear memory associated with the initial traumatic experience. However, the subsequent prolonged exposure to such stimulus creates an additional layer of neural stress. Although the mechanism remains unclear, prolonged exposure therapy (PET) likely involve changes in synaptic plasticity, neurotransmitter function and inflammation; especially in parts of the brain concerned with the formation and retrieval of fear memory (Hippocampus and Prefrontal Cortex: PFC)...
April 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28438401/a-control-system-for-ultrasound-devices-utilized-for-inactivating-e-coli-in-wastewater
#10
H Ohrdes, I Ille, J Twiefel, J Wallaschek, R Nogueira, K-H Rosenwinkel
Sonochemical processes applied to wastewater treatment have an influence on the behavior of ultrasonic systems. This is especially due to the load characteristic of the sonochemical process itself and the temperature increase caused by internal damping within the converter. Hence, a controlling device is needed to guarantee the operation in resonance and to keep the vibration amplitude constant. This paper presents a digital control system for the operation of weak to strong damped ultrasonic devices and its application for inactivating Escherichia coli in wastewater...
April 16, 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28436078/oxygen-isotope-fractionations-across-individual-leaf-carbohydrates-in-grass-and-tree-species
#11
Marco M Lehmann, Bruno Gamarra, Ansgar Kahmen, Rolf T W Siegwolf, Matthias Saurer
Almost no δ(18) O data are available for leaf carbohydrates, leaving a gap in the understanding of the δ(18) O relationship between leaf water and cellulose. We measured δ(18) O values of bulk leaf water (δ(18) OLW ) and individual leaf carbohydrates (e.g. fructose, glucose, sucrose) in grass and tree species, and δ(18) O of leaf cellulose in grasses. The grasses were grown under two relative humidity (rH) conditions. Sucrose was generally (18) O-enriched compared to hexoses across all species with an apparent biosynthetic fractionation factor (εbio ) of more than 27‰ relative to δ(18) OLW , which might be explained by isotopic leaf water and sucrose synthesis gradients...
April 23, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28435873/role-of-damping-in-spin-seebeck-effect-in-yttrium-iron-garnet-thin-films
#12
Houchen Chang, P A Praveen Janantha, Jinjun Ding, Tao Liu, Kevin Cline, Joseph N Gelfand, Wei Li, Mario C Marconi, Mingzhong Wu
The role of damping in the spin Seebeck effect (SSE) was studied experimentally for the first time. The experiments used Y3Fe5O12 (YIG)/Pt bilayered structures where the YIG films exhibit very similar structural and static magnetic properties but very different damping. The data show that a decrease in the damping gives rise to an increase in the SSE coefficient, which is qualitatively consistent with some of the theoretical models. This response also shows quasi-linear behavior, which was not predicted explicitly by previous studies...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28435516/docosahexaenoic-acid-dha-promotes-immunogenic-apoptosis-in-human-multiple-myeloma-cells-induces-autophagy-and-inhibits-stat3-in-both-tumor-and-dendritic-cells
#13
Donatella D'Eliseo, Livia Di Renzo, Angela Santoni, Francesca Velotti
Docosahexaenoic acid (DHA), a ω-3 polyunsaturated fatty acid found in fish oil, is a multi-target agent and exerts anti-inflammatory and anticancer activities alone or in combination with chemotherapies. Combinatorial anticancer therapies, which induce immunogenic apoptosis, autophagy and STAT3 inhibition have been proposed for long-term therapeutic success. Here, we found that DHA promoted immunogenic apoptosis in multiple myeloma (MM) cells, with no toxicity on PBMCs and DCs. Immunogenic apoptosis was shown by the emission of specific DAMPs (CRT, HSP90, HMGB1) by apoptotic MM cells and the activation of their pro-apoptotic autophagy...
January 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28435354/control-efficacy-of-streptomyces-sp-a501-against-ginseng-damping-off-and-its-antifungal-substance
#14
Nguyen Van Minh, E-Eum Woo, Gang-Seon Lee, Dae-Won Ki, In-Kyoung Lee, Sang-Yeob Lee, Kyeonghun Park, Jaekyeong Song, Jae Eul Choi, Bong-Sik Yun
Ginseng damping-off, caused by the fungal pathogens Rhizoctonia solani and Pythium sp., is a critical disease in ginseng seedling. In a continuing effort to find microorganisms with the potential of acting as a biocontrol agent against Rhizoctonia damping-off, we found that a Streptomyces sp. A501 showed significant antifungal activity against Rhizoctonia solani. In field experiment to test the efficacy of Streptomyces sp. A501 in controlling ginseng damping-off, the incidence of damping-off disease was meaningfully reduced when ginseng seeds were soaked in the culture broth of Streptomyces sp...
March 2017: Mycobiology
https://www.readbyqxmd.com/read/28434879/sonoluminescence-and-acoustic-emission-spectra-at-different-stages-of-cavitation-zone-development
#15
N V Dezhkunov, A Francescutto, L Serpe, R Canaparo, G Cravotto
The way in which a cavitation zone develops in a focused pulsed ultrasound field is studied in this work. Sonoluminescence (SL), total hydrophone output and cavitation noise spectra have been recorded across a gradual, smooth increase in applied voltage. It is shown that the cavitation zone passes through a number of stages of evolution, according to increasing ultrasound intensity, decreasing pulse period and increasing ultrasound pulse duration. Sonoluminescence is absent in the first phase and the hydrophone output spectra consists of a main line with two or three harmonics whose intensity is much lower than that of the main (fundamental) line...
April 6, 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28433631/detection-of-camp-and-of-pka-activity-in-saccharomyces-cerevisiae-single-cells-using-fluorescence-resonance-energy-transfer-fret-probes
#16
Sonia Colombo, Serena Broggi, Maddalena Collini, Laura D'Alfonso, Giuseppe Chirico, Enzo Martegani
In Saccharomyces cerevisiae the second messenger cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) play a central role in metabolism regulation, stress resistance and cell cycle progression. To monitor cAMP levels and PKA activity in vivo in single S. cerevisiae cells, we expressed an Epac-based FRET probe and a FRET-based A-kinase activity reporter, which were proven to be useful live-cell biosensors for cAMP levels and PKA activity in mammalian cells. Regarding detection of cAMP in single yeast cells, we show that in wild type strains the CFP/YFP fluorescence ratio increased immediately after glucose addition to derepressed cells, while no changes were observed when glucose was added to a strain that is not able to produce cAMP...
April 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28433439/cardiac-amyloidosis-shows-decreased-diastolic-function-as-assessed-by-echocardiographic-parameterized-diastolic-filling
#17
Katrin Salman, Peter A Cain, Benjamin T Fitzgerald, Martin G Sundqvist, Martin Ugander
Cardiac amyloidosis is a rare but serious condition with poor survival. One of the early findings by echocardiography is impaired diastolic function, even before the development of cardiac symptoms. Early diagnosis is important, permitting initiation of treatment aimed at improving survival. The parameterized diastolic filling (PDF) formalism entails describing the left ventricular filling pattern during early diastole using the mathematical equation for the motion of a damped harmonic oscillator. We hypothesized that echocardiographic PDF analysis could detect differences in diastolic function between patients with amyloidosis and controls...
April 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28432331/nontrivial-nonradiating-all-dielectric-anapole
#18
Nikita A Nemkov, Ivan V Stenishchev, Alexey A Basharin
Dynamic anapole is a promising element for future nonradiating devices, such as cloaked sources and sensors, quantum emitters, and especially the sources for observing dynamic Aharonov-Bohm effect. However, the anapole response can be damped by the Joule losses. In this paper we theoretically propose and experimentally demonstrate a novel type of active all-dielectric source, which is in some sense, realizes the elementary anapole of Afanasiev, and study its radiative/nonradiative regimes in the microwave range...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431469/enhanced-response-time-of-electrowetting-lenses-with-shaped-input-voltage-functions
#19
Omkar D Supekar, Mo Zohrabi, Juliet T Gopinath, Victor M Bright
Adaptive optical lenses, based on the electrowetting principle, are being rapidly implemented in many applications such as microscopy, remote sensing, displays, and optical communication. To characterize the response of these electrowetting lenses, the dependence on DC driving voltage functions was investigated in a low viscosity liquid system. Cylindrical lenses with inner diameter 2.45 and 3.95-mm were used to characterize the dynamic behavior of the liquids under DC voltage electrowetting actuation. By increasing the rise time of the input exponential driving voltage, the originally underdamped system response can be damped, enabling a smooth response from the lens...
April 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28430233/sensitivity-tests-on-the-convergence-tendency-of-the-scattering-order-formulation-of-the-discrete-dipole-approximation
#20
Carynelisa Haspel, Masada Tzabari
In this study, we performed a series of sensitivity tests in order to elucidate the convergence tendency of the scattering order formulation (SOF) of the discrete dipole approximation (DDA). Using both the original formulation of the SOF and a new marching SOF, the progression of orders of scattering marches, along with the propagation of the incident plane wave through the scatterer, allow dipoles that come into steady-state oscillation with the incident wave earlier to more quickly advance to the next order of scattering that is local to them...
April 20, 2017: Applied Optics
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