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https://www.readbyqxmd.com/read/29241180/high-mobility-group-box1-inhibitor-glycyrrhizic-acid-attenuates-kidney-injury-in-streptozotocin-induced-diabetic-rats
#1
Hong Zhang, Ru Zhang, Juan Chen, Min Shi, Wei Li, Xiangcheng Zhang
BACKGROUND/AIMS: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. METHODS: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks...
November 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29241031/the-protective-effect-of-dexmedetomidine-on-lps-induced-acute-lung-injury-through-the-hmgb1-mediated-tlr4-nf-%C3%AE%C2%BAb-and-pi3k-akt-mtor-pathways
#2
Lu Meng, Longyun Li, Shan Lu, Kai Li, Zhenbo Su, Yunyun Wang, Xiaodi Fan, Xuyang Li, Guoqing Zhao
The aim of present study was to evaluate the protective effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its possible mechanisms mediated by HMGB1. In vivo, pulmonary pathology observation and myeloperoxidase (MPO) activity were also examined to evaluate the protective effect of DEX in the lungs. Tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in bronchoalveolar lavage fluid (BALF), serum and lung tissues LPS-induced rats were detected...
December 11, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29238012/announcement-ueda-heart-award-for-2017
#3
(no author information available yet)
We are pleased to announce that the following 4 articles have been selected for the the UEDA Heart Awards for the Year 2017.First PlaceGeneration of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to CardiomyocytesAkihito Hashimoto, Atsuhiko T. Naito, Jong-Kook Lee, Rika Kitazume-Taneike, Masamichi Ito, Toshihiro Yamaguchi, Ryo Nakata, Tomokazu Sumida, Katsuki Okada, Akito Nakagawa, Tomoaki Higo, Yuki Kuramoto, Taku Sakai, Koji Tominaga, Takeshi Okinaga, Shigetoyo Kogaki, Keiichi Ozono, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata, Hiroyuki Morita, Akihiro Umezawa, Issei KomuroInt Heart J 2016 ; 57 (1) : 112-117Second PlaceEffect of Allopurinol on Myocardial Energy Metabolism in Chronic Heart Failure Rats After Myocardial InfarctZhenzhen Wang, Juan Ding, Xiang Luo, Siliang Zhang, Gang Yang, Que Zhu, Dichuan LiuInt Heart J 2016 ; 57 (6) : 753-759Third PlacePlasma Levels of Receptor for Advanced Glycation End-Products and High-Mobility Group Box 1 in Patients With Pulmonary HypertensionSatoshi Suzuki, Kazuhiko Nakazato, Koichi Sugimoto, Akiomi Yoshihisa, Takayoshi Yamaki, Hiroyuki Kunii, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika TakeishiInt Heart J 2016 ; 57 (2) : 234-240Tolvaptan Reduces Long-Term Total Medical Expenses and Length of Stay in Aquaporin-Defined RespondersTeruhiko Imamura, Koichiro Kinugawa, Daisuke Nitta, Issei KomuroInt Heart J 2016 ; 57 (5) : 593-599November 2017International Heart Journal Association...
2017: International Heart Journal
https://www.readbyqxmd.com/read/29236588/topical-glycyrrhizin-is-therapeutic-for-pseudomonas-aeruginosa-keratitis
#4
Sandamali A Ekanayaka, Sharon A McClellan, Ronald P Barrett, Linda D Hazlett
PURPOSE: Glycyrrhizin (GLY), an inhibitor of high-mobility group box 1 (HMGB1) protects prophylactically against Pseudomonas aeruginosa keratitis. However, the therapeutic potential of GLY to enhance an antibiotic has not been tested and is our purpose. METHODS: C57BL/6 mice (B6) were infected with a clinical isolate (KEI 1025) of P. aeruginosa and treated topically at 6 h postinfection (p.i.) with GLY or phosphate-buffered saline (PBS). Clinical scores, photography with a slit lamp, enzyme-linked immunosorbent assay, myeloperoxidase assay, bacterial plate counts, histopathology, reactive oxygen/nitrogen species (ROS/RNS) assays, and in vitro macrophage (Mφ) stimulation assays were used to assess effects of GLY treatment...
December 13, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29233668/expression-of-hmgb1-in-maternal-exposure-to-fine-particulate-air-pollution-induces-lung-injury-in-rat-offspring-assessed-with-micro-ct
#5
Wenting Tang, Suran Huang, Lili Du, Wen Sun, Zhiqiang Yu, Yanmei Zhou, Jingsi Chen, Xiuying Li, Xiaomei Li, Bolan Yu, Dunjin Chen
OBJECTIVES: Maternal particulate matter with less than 2.5 μm in diameter (PM2.5) is associated with an increased risk for acute lower respiratory infections and allergic airway inflammation; however, its effect on the developing lung remains unclear. The aim of this study is to determine the effect of maternal PM2.5 during pregnancy on lung development in offspring. METHODS: Timed pregnant Sprague-Dawley rats were treated with PM2.5 (0.1, 0.5, 2.5, or 7.5 mg/kg) once every 3 days from day 0-18 of pregnancy and delivered at term...
December 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29227009/fetal-liver-injury-ameliorated-by-migration-inhibitory-factor-inhibition-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#6
Zheng-Da Guo, Liang Zhao, Peng Wang, Wen-Hong Deng, Qiao Shi, Teng Zuo, Yu-Pu Hong, Wei-Xing Wang
AIM: This study was designed to investigate and assess fetal liver injury in a rat model of acute pancreatitis in pregnancy (APIP) as well as its possible mechanisms and potential therapeutic targets. METHODS: The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP. In addition, sham-operated rats at later gestation were set as controls...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29215715/hmgb1-contributes-to-the-irradiation-induced-endothelial-barrier-injury-through-receptor-for-advanced-glycation-endproducts-rage
#7
Haihong Zhou, Congli Jin, Lili Cui, Huaijie Xing, Jun Liu, Wang Liao, Haojie Liao, Yangsheng Yu
This study aimed to investigate whether HMGB1 (high mobility group box-1 protein) and receptor for advanced glycation end products (RAGE) were involved in the irradiation-induced endothelial barrier damage and their mechanism. We constructed the damage model of endothelium barrier model with bEnd.3 cells. The permeability of endothelial barrier was detected by sodium fluorescein (Na-F) permeation test, and the irradiation dose which could induce permeability transition was determined by being exposed to different irradiation doses (5Gy, 10Gy, 15Gy, 20Gy)...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29212801/roles-of-high-mobility-group-box-1-and-thrombin-in-murine-pulmonary-fibrosis-and-the-therapeutic-potential-of-thrombomodulin
#8
Takashi Kida, Takahiro Seno, Hidetake Nagahara, Takuya Inoue, Amane Nakabayashi, Yuji Kukida, Kazuki Fujioka, Wataru Fujii, Makoto Wada, Masataka Kohno, Yutaka Kawahito
Cross-talk between inflammation and coagulation plays important roles in acute or subacute progressive pulmonary fibrosis characterized by diffuse alveolar damage. Thrombomodulin is a physiological inhibitor of high-mobility group box 1 (HMGB1) and thrombin, and may be effective for this condition. This study investigated the roles of HMGB1 and thrombin in the pathophysiology of bleomycin-induced pulmonary fibrosis and the efficacy of recombinant human soluble thrombomodulin (rhTM). Pulmonary fibrosis was induced in wild-type C57BL/6 mice by intratracheal instillation of bleomycin...
December 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29207644/protection-by-simvastatin-on-hyperglycemia-induced-endothelial-dysfunction-through-inhibiting-nlrp3-inflammasomes
#9
Zhen-Huan Lv, Trinh Anh Phuong, Shi-Jie Jin, Xiao-Xue Li, Ming Xu
Recent studies have demonstrated that NLRP3 inflammasome complex acts as pivotal elements to initiate inflammatory responses and plays an important role in the dysfunction of cardiovascular complications. Meanwhile, simvastatin prevents vascular endothelial dysfunction from inflammasome invasion contributing to reduce cardiovascular risk. However, Whether or not the simvastatin improves vascular endothelial barrier function through inhibiting the activation of NLRP3 inflammasome pathway remains unknown. Here, we explored the role and mechanisms of simvastatin in the activation of NLRP3 inflammasome which are involved in vascular endothelial hyperpermeability causing by the disruption of tight junction protein ZO-1 and adherens junction protein VE-Cadherin, an early initiation of cardiovascular complication...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203538/high-mobility-group-box-1-orchestrates-tissue-regeneration-via-cxcr4
#10
Mario Tirone, Ngoc Lan Tran, Chiara Ceriotti, Andrea Gorzanelli, Monica Canepari, Roberto Bottinelli, Angela Raucci, Stefania Di Maggio, César Santiago, Mario Mellado, Marielle Saclier, Stéphanie François, Giorgia Careccia, Mingzhu He, Francesco De Marchis, Valentina Conti, Sabrina Ben Larbi, Sylvain Cuvellier, Maura Casalgrandi, Alessandro Preti, Bénédicte Chazaud, Yousef Al-Abed, Graziella Messina, Giovanni Sitia, Silvia Brunelli, Marco Emilio Bianchi, Emilie Vénéreau
Inflammation and tissue regeneration follow tissue damage, but little is known about how these processes are coordinated. High Mobility Group Box 1 (HMGB1) is a nuclear protein that, when released on injury, triggers inflammation. We previously showed that HMGB1 with reduced cysteines is a chemoattractant, whereas a disulfide bond makes it a proinflammatory cytokine. Here we report that fully reduced HMGB1 orchestrates muscle and liver regeneration via CXCR4, whereas disulfide HMGB1 and its receptors TLR4/MD-2 and RAGE (receptor for advanced glycation end products) are not involved...
December 4, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29201164/electroacupuncture-improves-acute-bowel-injury-recovery-in-rat-models
#11
Jiannong Wu, Bin Lyu, Tie'er Gan, Lingcong Wang, Meifei Zhu
Electroacupuncture (EA) accelerates intestinal functional recovery in sepsis. The present study investigated ghrelin and ghrelin receptor (GSH-R) levels during EA in rats with acute bowel injury (ABI). Rats were grouped into four groups: Sham, ABI, ABI+EA and ABI+GHRA+EA (n=12 per group). ABI was induced by cecal ligation and puncture (CLP). EA on bilateral Zusanli acupoints was performed following CLP. GSH-R blocker (GHRA) was used following CLP but prior to EA for ABI+GHRA+EA rats. Rats were sacrificed 12 h following CLP...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200952/prognostic-significance-of-high-mobility-group-box-protein-1-genetic-polymorphisms-in-rheumatoid-arthritis-disease-outcome
#12
Li-Hong Wang, Min-Huan Wu, Po-Chun Chen, Chen-Ming Su, Guohong Xu, Chien-Chung Huang, Chun-Hao Tsai, Yuan-Li Huang, Chih-Hsin Tang
Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes chronic inflammation of the joints. Analysis of genetic variants offers promise for guiding treatment and improving outcomes in RA. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in several biological functions including immune response, cell survival and apoptosis. We investigated the effects of HMGB1 gene polymorphisms on the risk of RA disease progression in a cohort of Chinese Han individuals...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29200665/the-role-of-high-mobility-group-box-1-and-its-crosstalk-with-microbiome-in-rheumatoid-arthritis
#13
REVIEW
Federico Biscetti, Andrea Flex, Stefano Alivernini, Barbara Tolusso, Elisa Gremese, Gianfranco Ferraccioli
Rheumatoid arthritis (RA) is a chronic, definitely disabling, and potentially severe autoimmune disease. Although an increasing number of patients are affected, a key treatment for all patients has not been discovered. High-mobility group box-1 (HMGB1) is a nuclear protein passively and actively released by almost all cell types after several stimuli. HMGB1 is involved in RA pathogenesis, but a convincing explanation about its role and possible modulation in RA is still lacking. Microbiome and its homeostasis are altered in patients with RA, and the microbiota restoration has been proposed to patients with RA...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29198620/the-role-of-hmgb1-in-heart-transplantation
#14
REVIEW
Qianying Lv, Chao Li, Yarui Mo, Long He
There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of heart allograft rejection. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the regulation of immunity and inflammation...
November 30, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29197515/fingolimod-anti-inflammatory-and-neuroprotective-effects-modulation-of-rage-axis-in-multiple-sclerosis-patients
#15
Zohara Sternberg, Channa Kolb, Kailash Chadha, Adam Nir, Raphael Nir, Rayan George, Joseph Johnson, Jinhee Yu, David Hojnacki
BACKGROUND: We investigated Fingolimod treatment effects on the RAGE (receptor for advanced glycation endproducts) axis in multiple sclerosis (MS) patients. The primary outcome of the study was whether Fingolimod treatment increases serum levels of the soluble RAGE isoforms, sRAGE and esRAGE - both being considered putative endogenous inhibitors of RAGE signaling. Additional variables were serum levels of RAGE ligands, the high mobility group box (HMGB)1 and pentosidine. METHODS: Serum levels of the study variables were measured by ELISA, and compared between baseline (before Fingolimod treatment) and 6 and 12 months post-drug treatment in 17 relapsing MS patients...
November 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29196961/%C3%AE-7-nachr-activation-has-an-opposite-effect-on-healing-of-covered-and-uncovered-wounds
#16
Jiao-Yong Li, Shu-Kun Jiang, Lin-Lin Wang, Meng-Zhou Zhang, Shuai Wang, Zhen-Fei Jiang, Yu-Li Liu, Hao Cheng, Miao Zhang, Rui Zhao, Da-Wei Guan
The α7 nicotinic acetylcholine receptor (α7-nAChR) is associated with inflammation, re-epithelialization, and angiogenesis in wound healing process. A recent study demonstrated that PNU-282987, a selective agonist of α7-nAChR, accelerates the repair of diabetic excisional wounds. Whether α7-nAChR activation promotes non-diabetic wounds healing is unknown. The aim of this study was to evaluate the effects of α7-nAChR activation on non-diabetic wound healing. The effects were evaluated in two wound models...
December 1, 2017: Inflammation
https://www.readbyqxmd.com/read/29196860/role-of-thrombin-in-soluble-thrombomodulin-induced-suppression-of-peripheral-hmgb1-mediated-allodynia-in-mice
#17
Ryuichi Tsujita, Maho Tsubota, Yusuke Hayashi, Haruka Saeki, Fumiko Sekiguchi, Atsufumi Kawabata
High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively. Thrombomodulin (TM), an endothelial membrane protein, and soluble TM, known as TMα, promote thrombin-mediated activation of protein C and also sequester HMGB1, which might facilitate thrombin degradation of HMGB1...
December 1, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29196733/regulation-of-hmgb3-by-antitumor-mir-205-5p-inhibits-cancer-cell-aggressiveness-and-is-involved-in-prostate-cancer-pathogenesis
#18
Yasutaka Yamada, Rika Nishikawa, Mayuko Kato, Atsushi Okato, Takayuki Arai, Satoko Kojima, Kazuto Yamazaki, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki
Our recent determination of a microRNA (miRNA) expression signature in prostate cancer (PCa) revealed that miR-205-5p was significantly reduced in PCa tissues and that it acted as an antitumor miRNA. The aim of this study was to identify oncogenic genes and pathways in PCa cells that were regulated by antitumor miR-205-5p. Genome-wide gene expression analyses and in silico miRNA database searches showed that 37 genes were putative targets of miR-205-5p regulation. Among those genes, elevated expression levels of seven in particular (HMGB3, SPARC, MKI67, CENPF, CDK1, RHOU, and POLR2D) were associated with a shorter disease-free survival in a large number of patients in the The Cancer Genome Atlas (TCGA) database...
December 1, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29195782/hmgb1-mediates-depressive-behavior-induced-by-chronic-stress-through-activating-the-kynurenine-pathway
#19
Bo Wang, Yong-Jie Lian, Wen-Jun Su, Wei Peng, Xin Dong, Lin-Lin Liu, Hong Gong, Ting Zhang, Chun-Lei Jiang, Yun-Xia Wang
Our previous study has reported that the proactive secretion and role of central high mobility group box 1 (HMGB1) in lipopolysaccharide-induced depressive behavior. Here, the potential mechanism of HMGB1 mediating chronic-stress-induced depression through the kynurenine pathway (KP) was further explored both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS). Sucrose preference and Barnes maze test were performed to reflect depressive behaviors. The ratio of kynurenine (KYN)/tryptophan (Trp) represented the enzyme activity of indoleamine-2,3-dioxygenase (IDO)...
November 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29195627/ethyl-pyruvate-is-renoprotective-against-ischemia-reperfusion-injury-under-hyperglycemia
#20
Ji Hae Jun, Jong Wook Song, Eun-Jung Shin, Young-Lan Kwak, Nakcheol Choi, Jae-Kwang Shim
BACKGROUND: Hyperglycemia (HG) is common in cardiovascular surgeries due to diabetes, inflammation, and the neuroendocrine stress response. HG aggravates renal ischemia-reperfusion (I/R) injury through an increased inflammatory response, and blunts the protective effect of various measures. Ethyl pyruvate (EP) provides anti-inflammatory effects against I/R injury via inhibition of high-mobility group box 1 protein (HMGB1) release. This study aimed to determine the renoprotective effect of EP against I/R injury under HG...
November 1, 2017: Journal of Thoracic and Cardiovascular Surgery
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