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https://www.readbyqxmd.com/read/29027228/high-mobility-group-box-1-protein-orchestrates-responses-to-tissue-damage-via-inflammation-innate-and-adaptive-immunity-and-tissue-repair
#1
REVIEW
Marco E Bianchi, Massimo P Crippa, Angelo A Manfredi, Rosanna Mezzapelle, Patrizia Rovere Querini, Emilie Venereau
A single protein, HMGB1, directs the triggering of inflammation, innate and adaptive immune responses, and tissue healing after damage. HMGB1 is the best characterized damage-associated molecular pattern (DAMP), proteins that are normally inside the cell but are released after cell death, and allow the immune system to distinguish between antigens that are dangerous or not. Notably, cells undergoing severe stress actively secrete HMGB1 via a dedicated secretion pathway: HMGB1 is relocated from the nucleus to the cytoplasm and then to secretory lysosomes or directly to the extracellular space...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29025713/neutrophil-elastase-increases-airway-ceramide-levels-via-upregulation-of-serine-palmitoyltransferase
#2
Sophia Karandashova, Apparao B Kummarapurugu, Shuo Zheng, Charles Chalfant, Judith A Voynow
Altered sphingolipid metabolism is associated with increased inflammation; however, the impact of inflammatory mediators, including neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. Using a well-characterized mouse model of NE oropharyngeal aspiration, we investigated a potential link between NE-induced airway inflammation and increased synthesis of various classes of sphingolipids, including ceramide species. Sphingolipids in bronchoalveolar lavage fluids (BAL) were identified and quantified using reverse phase high-performance liquid chromatography/electrospray ionization tandem mass spectrometry analysis...
October 12, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29023630/the-hmgb1-is-increased-in-csf-of-patients-with-an-anti-nmdar-encephalitis
#3
P Ai, X Zhang, Z Xie, G Liu, X Liu, S Pan, H Wang
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Interleukin (IL)-6 and IL-17A may play important roles in the pathogenesis of this disease. High-mobility group box protein 1 (HMGB1), a small but highly conserved ubiquitous protein, is recognized to be a potent innate inflammatory mediator that can activate the nuclear factor light chain enhancer of activated B cells and release cytokines such as IL-6 and IL-17A when released extracellularly...
October 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29017661/-advances-in-the-role-of-autophagy-in-acute-pancreatitis
#4
He Xia, Liang Zhao, Weixing Wang
Autophagy is a self-protect cellular mechanism by which the unneeded cellular structure or impaired protein are targeted to degeneration. Acute pancreatitis (AP) is associated with autophagy tightly. This article is aimed to mainly elaborate the phenomenon that AP can be triggered by impaired autophagy and the mechanism of AP exacerbation by damaged autophagy. In AP, the reasons of impaired autophagy is dysfunction of cathepsins and lysosome associated membrane protein, which present as vacuoles accumulation in acinar cells and combination disorder of autophagolysosome, finally to activation of trypsin...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29017437/high-expression-of-high-mobility-group-box-1-in-menstrual-blood-implications-for-endometriosis
#5
Keiko Shimizu, Yasuhiko Kamada, Ai Sakamoto, Miwa Matsuda, Mikiya Nakatsuka, Yuji Hiramatsu
Endometriosis is a benign gynecologic disease characterized by the presence of ectopic endometrium and associated with inflammation and immune abnormalities. However, the molecular basis for endometriosis is not well understood. To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). A total of 139 patients were enrolled in this study; 84 had endometriosis and 55 were nonendometriotic gynecological patients (control)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28990078/increased-expression-of-high-mobility-group-box-protein-1-and-vascular-endothelial-growth-factor-in-placenta-previa
#6
Han Xie, Ping Qiao, Yi Lu, Ying Li, Yuping Tang, Yiying Huang, Yirong Bao, Hao Ying
Placenta previa is often associated with preterm delivery, reduced birth weight, a higher frequency of placental accreta and postpartum haemorrhage, and increased likelihood of blood transfusion. The present study aimed to examine the expression of high mobility group box protein 1 (HMGB1) in the placenta of women with or without placenta previa. The study group consisted of placental tissues obtained from women with or without placenta previa. The expression levels of HMGB1 and vascular endothelial growth factor (VEGF) were evaluated in the placental tissues using reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry...
October 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28989160/-mechanism-of-migration-and-release-of-%C3%A2-high-mobility-group-box-1
#7
Xin Zhao, Ben Lü, Erhua Wang
High mobility group box-1 (HMGB1) is an evolutionarily conserved protein, which widely exists in mammals. HMGB1 contains the nucleus localization sequences. Intracellular and extracellular HMGB1 shows different biological functions. Extracellular HMGB1 is closely related to sepsis, cancer, rheumatoid immune, atherosclerosis, ischemia-reperfusion injury and so on. The mobilization of HMGB1 from the nucleus to the cytoplasm and subsequent release involves the processes of post-translation modification, active secretion and nuclear localization...
September 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28988015/the-dose-dependent-effect-of-sox9-and-its-incidence-in-colorectal-cancer
#8
REVIEW
Corinne Prévostel, Philippe Blache
A member of the Sry-related HMG-box family of transcription factors (SOX9) is a transcription factor that belongs to the superfamily of High Mobility Group (HMG) domain transcription factors. SOX9 is expressed in a variety of tissues, including as the intestinal epithelium, where it is now recognised as an important actor for homeostasis. Beside, a high level of SOX9 has recently been correlated with a good prognosis for stage II colorectal cancers. However, growing evidence indicates that deciphering the function of SOX9 in the intestine has to take into account a dose-dependent effect of SOX9...
October 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28987932/ethyl-pyruvate-ameliorates-inflammatory-arthritis-in-mice
#9
Seung Min Jung, Jaeseon Lee, Seung Ye Baek, Juhyun Lee, Se Gwang Jang, Seung-Min Hong, Jin-Sil Park, Mi-La Cho, Sung-Hwan Park, Seung-Ki Kwok
OBJECTIVES: Ethyl pyruvate (EP) is the ethyl ester of pyruvate and has antioxidative and anti-inflammatory effects. This study aimed to evaluate the therapeutic effect of EP in inflammatory arthritis and to identify the underlying mechanisms. METHODS: Mice with collagen-induced arthritis (CIA) were treated with the vehicle control or EP at 20mg/kg, and clinical and histological analyses were performed on the animals. The differentiation of murine CD4+ T cells into T helper 17 (Th17) cells in the presence of EP was investigated in vitro...
October 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28981603/high-mobility-group-box-1-protein-is-involved-in-the-protective-effect-of-saquinavir-on-ventilation-induced-lung-injury-in-mice
#10
Xin Wang, Renlingzi Zhang, Yao Tong, Xibing Ding, Shuqing Jin, Xiang Zhao, Jiaying Zong, Zhixia Chen, Timothy R Billiar, Quan Li
Saquinavir (SQV) is the first FDA approved HIV protease inhibitor. Previous studies showed that SQV can limit Toll-like receptor-4 (TLR4)-mediated inflammatory pathway and nuclear factor-κB (NF-κB) activation, thereby playing a protective role in many kinds of diseases. High-mobility group box 1 (HMGB1) has been identified as an inflammatory mediator and it might express its toxicity in a short period of time in ventilator-induced lung injury (VILI). In this study, C57BL/6 mice were randomly divided into four groups (n = 10): control group and control with SQV group (Con + SQV) were spontaneous breath...
October 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28976774/proteomic-analysis-of-extracellular-hmgb1-identifies-binding-partners-and-exposes-its-potential-role-in-airway-epithelial-cell-homeostasis
#11
Sharon L I Wong, Joyce To, Jerran Santos, Venkata Sita Rama Raju Allam, John P Dalton, Steven Philip Djordjevic, Sheila Donnelly, Matthew Paul Padula, Maria B Sukkar
The release of damage-associated molecular patterns (DAMPs) by airway epithelial cells is believed to play a crucial role in the initiation and development of chronic airway conditions such as asthma and chronic obstructive pulmonary disease (COPD). Intriguingly, the classic DAMP high-mobility group box-1 (HMGB1) is detected in the culture supernatant of airway epithelial cells under basal conditions, indicating a role for HMGB1 in the regulation of epithelial cellular and immune homeostasis. In order to gain contextual insight into the potential role of HMGB1 in airway epithelial cell homeostasis, we used the orthogonal and complimentary methods of high resolution clear native electrophoresis, immunoprecipitation and pull-downs, coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) to profile HMGB1 and its binding partners in the culture supernatant of unstimulated airway epithelial cells...
October 4, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28975966/hmgb1-affects-the-development-of-pulmonary-arterial-hypertension-via-rage
#12
W-J Li, K Hu, J-P Yang, X-Y Xu, N Li, Z-P Wen, H Wang
OBJECTIVE: To investigate the effect of high-mobility group box 1 (HMGB1) on the proliferation, migration and inflammatory response of human pulmonary artery smooth muscle cells (HPASMCs) and human pulmonary artery endothelial cells (HPAECs) through the receptor for advanced glycation end products (RAGE) and to investigate the mechanism of action underlying the effect of HMGB1 on pulmonary arterial hypertension. MATERIALS AND METHODS: The effect of HMGB1 on the proliferation of the two cell types was examined using the MTT assay under environmental hypoxia (incubation with 1...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28970183/high-mobility-group-b1-up-regulates-angiogenic-and-fibrogenic-factors-in-human-retinal-pigment-epithelial-arpe-19-cells
#13
Yo-Chen Chang, Chia-Wei Lin, Ming-Chu Hsieh, Horng-Jiun Wu, Wen-Sheng Wu, Wen-Chuan Wu, Ying-Hsien Kao
Hypoxia-induced retinal neovascularization plays a central role in the pathogenesis of diabetic retinopathy. This study aimed to investigate whether hypoxia leads to the release of nuclear high mobility group box 1 (HMGB1) peptides from cultured retinal pigment epithelial ARPE-19 cells, to determine the effect of HMGB1 on angiogenic cytokine production and elucidate the involved signaling pathways. A chemical hypoxia mimetic agent, cobalt chloride, induced SIRT1 downregulation, HMGB1 nucleocytoplasmic relocation and extracellular release from ARPE-19 cells, implicating its autocrine function...
September 29, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28969092/the-dual-role-and-therapeutic-potential-of-high-mobility-group-box-1-in-cancer
#14
REVIEW
Si-Jia He, Jin Cheng, Xiao Feng, Yang Yu, Ling Tian, Qian Huang
High-mobility group box 1 (HMGB1) is an abundant protein in most eukaryocytes. It can bind to several receptors such as advanced glycation end products (RAGE) and Toll-like receptors (TLRs), in direct or indirect way. The biological effects of HMGB1 depend on its expression and subcellular location. Inside the nucleus, HMGB1 is engaged in many DNA events such as DNA repair, transcription, telomere maintenance, and genome stability. While outside the nucleus, it possesses more complicated functions, including regulating cell proliferation, autophagy, inflammation and immunity...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968989/hmgb1-promotes-myeloid-derived-suppressor-cells-and-renal-cell-carcinoma-immune-escape
#15
Jinfeng Li, Jiajia Sun, Ruiming Rong, Long Li, Wenjun Shang, Dongkui Song, Guiwen Feng, Feifei Luo
Despite high immunogenicity and marked presence of immune cells in the RCC(renal cell carcinoma), immunotherapy fails to develop effective anti-tumor immune responses. This is due to the negative regulatory factors in the tumor microenvironment. As the main contributor of immunosuppression, myeloid-derived suppressor cells (MDSCs) inhibited anti-tumor immunity and promoted tumor progression. Meanwhile, it is confirmed that high mobility group box-1 protein (HMGB1) shows a high expression in many solid tumors and HMGB1 with high expression is involved in tumor immune escape...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967436/the-angiogenic-properties-of-human-adipose-derived-stem-cells-hascs-are-modulated-by-the-high-mobility-group-box-protein-1-hmgb1
#16
Federico Biscetti, Stefano Gentileschi, Flavio Bertucci, Maria Servillo, Vincenzo Arena, Flavia Angelini, Egidio Stigliano, Giuseppina Bonanno, Giovanni Scambia, Benedetto Sacchetti, Luca Pierelli, Raffaele Landolfi, Andrea Flex
Peripheral arterial disease (PAD), is a major health problem. Many studies have been focused on the possibilities of treatment offered by vascular regeneration. Human adipose-derived stem cells (HASCs), multipotent CD34+ stem cells found in the stromal-vascular fraction of adipose tissues, which are capable to differentiate into multiple mesenchymal cell types. The High mobility group box 1 protein (HMGB1) is a nuclear protein involved in angiogenesis. The aim of the study was to define the role of HMGB1 in cell therapy with HASCs, in an animal model of PAD...
September 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28966327/dpp4-inhibition-ameliorates-cardiac-function-by-blocking-the-cleavage-of-hmgb1-in-diabetic-mice-after-myocardial-infarction
#17
Akihiko Sato, Satoshi Suzuki, Shunsuke Watanabe, Takeshi Shimizu, Yuichi Nakamura, Tomofumi Misaka, Tetsuro Yokokawa, Tetsuro Shishido, Shu-Ichi Saitoh, Takafumi Ishida, Isao Kubota, Yasuchika Takeishi
High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, promotes angiogenesis and tissue repair, resulting in restored cardiac function after myocardial infarction (MI). Although dipeptidyl peptidase 4 (DPP4) degrades certain peptides, it remains unclear as to whether HMGB1 is a substrate of DPP4 and whether DPP4 inhibition prevents the cleavage of HMGB1.In transgenic mice with cardiac-specific overexpression of HMGB1 (TG) and wild-type mice (WT), a diabetic state was induced by streptozotocin, and MI was created by ligation of the left anterior descending coronary artery...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28966323/porphyromonas-gingivalis-elevated-high-mobility-group-box-1-levels-after-myocardial-infarction-in-mice
#18
Rungtiwa Srisuwantha, Yuka Shiheido, Norio Aoyama, Hiroki Sato, Keitetsu Kure, Narongsak Laosrisin, Yuichi Izumi, Jun-Ichi Suzuki
High mobility group box 1 (HMGB1) is a nuclear protein released from necrotic cells, inducing inflammatory responses. Epidemiological studies suggested a possible association between periodontitis and cardiovascular diseases (CVDs). Due to tissue damage and necrosis of cardiac cells following myocardial infarction (MI), HMGB1 is released, activating an inflammatory reaction. However, it remains unclear whether periodontitis is also involved in myocardial damage. The purpose of this study was to determine the effect of the periodontal pathogen Porphyromonas gingivalis (P...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28962186/ulinastatin-attenuates-diabetes-induced-cardiac-dysfunction-by-the-inhibition-of-inflammation-and-apoptosis
#19
Wen-Ke Wang, Qing-Hua Lu, Xin Wang, Ben Wang, Juan Wang, Hui-Ping Gong, Lin Wang, Hao Li, Yi-Meng Du
Ulinastatin exhibits anti-inflammatory activity and protects the heart from ischemia/reperfusion injury. However, whether ulinastatin has a protective effect in diabetic cardiomyopathy is yet to be elucidated. The aim of the present study was to investigate the protective effects of ulinastatin against diabetic cardiomyopathy and its underlying mechanisms. A C57/BL6J mice model of diabetic cardiomyopathy was used and mice were randomly assigned to three groups: Control group, diabetes mellitus (DM) group and DM + ulinastatin treatment group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962177/high-mobility-group-box-1-in-diabetic-nephropathy
#20
Haitao Shi, Yingqi Che, Lin Bai, Jinling Zhang, Jingxu Fan, Huiling Mao
Type 2 diabetes (T2D) is a complex disorder caused by the combined effects of genetic inheritance and environmental factors. The abnormal secretion of albumin via urine is the characteristic feature of a diabetic nephropathy (DN) patient. Moreover, the detection of this observable characteristic feature of DN is quite late. As a result the time, at which DN is observable, large extent of kidney damage has already occurred. Thus, this late observation significantly decreases the chances of efficient management of DN and associated outcomes...
September 2017: Experimental and Therapeutic Medicine
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