keyword
MENU ▼
Read by QxMD icon Read
search

high mobility group box

keyword
https://www.readbyqxmd.com/read/28210782/toll-like-receptor-signaling-and-stages-of-addiction
#1
REVIEW
Fulton T Crews, T Jordan Walter, Leon G Coleman, Ryan P Vetreno
BACKGROUND: Athina Markou and her colleagues discovered persistent changes in adult behavior following adolescent exposure to ethanol or nicotine consistent with increased risk for developing addiction. Building on Dr. Markou's important work and that of others in the field, researchers at the Bowles Center for Alcohol Studies have found that persistent changes in behavior following adolescent stress or alcohol exposure may be linked to induction of immune signaling in brain. AIM: This study aims to illuminate the critical interrelationship of the innate immune system (e...
February 17, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28209360/levels-of-high-mobility-group-box-1-in-gingival-crevicular-fluid-in-nonsmokers-and-smokers-with-chronic-periodontitis
#2
Yi-Chun Lin, Ching-Yi Wu, Lien-Yu Chang, Ching-Chu Chen, Hsuan-Hung Chen, Yu-Lin Lai, Shan-Ling Hung
BACKGROUND/PURPOSE: High-mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a role in inflammatory disorders. Smoking is a well-established risk factor for periodontal disease. The aim of this study was to compare the levels of HMGB1 in the gingival crevicular fluid from periodontally healthy nonsmokers, chronic periodontitis nonsmokers, and chronic periodontitis smokers. Furthermore, the relationship between levels of HMGB1 and periodontal parameters was examined. METHODS: Periodontal parameters of 17 nonsmokers with chronic periodontitis, nine smokers with chronic periodontitis, and nine periodontally healthy nonsmokers were examined...
February 13, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28202124/-effect-of-heat-shock-factor-1-on-airway-hyperresponsiveness-and-airway-inflammation-in-mice-with-allergic-asthma
#3
Jing Wang, Li-Hong Xin, Wei Cheng, Zhen Wang, Wen Zhang
OBJECTIVE: To investigate the effect of heat shock factor 1 (HSF1) on airway hyperresponsiveness and airway inflammation in mice with asthma and possible mechanisms. METHODS: A total of 36 mice were randomly divided into four groups: control, asthma, HSF1 small interfering RNA negative control (siHSF1-NC), and siHSF1 intervention (n=9 each). Ovalbumin (OVA) sensitization and challenge were performed to induce asthma in the latter three groups. The mice in the siHSF1-NC and siHSF1 groups were treated with siHSF1-NC and siHSF1, respectively...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28199887/killing-colon-cancer-cells-through-pcd-pathways-by-a-novel-hyaluronic-acid-modified-shell-core-nanoparticle-loaded-with-rip3-in-combination-with-chloroquine
#4
Xueyan Hou, Chengli Yang, Lijing Zhang, Tingting Hu, Dan Sun, Hua Cao, Fan Yang, Gang Guo, Changyang Gong, Xiaoning Zhang, Aiping Tong, Rui Li, Yu Zheng
Due to extensive apoptosis defects and multidrug resistance, there is great interest regarding non-apoptotic programmed cell death (PCD) pathways, such as lysosomal-mediated programmed cell death (LM-PCD), necroptosis and autophagy. Because there is an intricate effector network among these PCD pathways, it is expected that they may act synergistically in cancer therapy. In this study, chloroquine (CQ) was found to significantly upregulate receptor-interacting protein kinase 3 (RIP3) expression, and RIP3 were involved in CQ-related autophagy...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28197072/hmgb1-mediates-autophagy-dysfunction-via-perturbing-beclin1-vps34-complex-in-dopaminergic-cell-model
#5
Jinsha Huang, Jiaolong Yang, Yan Shen, Haiyang Jiang, Chao Han, Guoxin Zhang, Ling Liu, Xiaoyun Xu, Jie Li, Zhicheng Lin, Nian Xiong, Zhentao Zhang, Jing Xiong, Tao Wang
Parkinson's disease (PD), a progressive neurodegenerative disorder, is characterized by irreversible dopaminergic neuron loss and intra-neuronal α-synuclein aggregation. High mobility group box 1 (HMGB1) has been proven to be involved in autophagy dysfunction induced by α-synuclein accumulation, and the Beclin1-vacuolar protein sorting 34 (Vps34) complex is of great importance to the initiation of autophagy. Nevertheless, the concrete interaction mechanism between HMGB1, α-synuclein and autophagy remains elusive, especially in the context of PD...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28196513/metabotropic-glutamate-receptor-5-may-be-involved-in-macrophage-plasticity
#6
Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze, David Mikeladze
BACKGROUND: Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity. To investigate the role of glutamatergic systems in macrophages physiology, we performed the transfection of mGluR5 cDNAs into RAW-264.7 cells. RESULTS: Comparative analysis of modified (RAW-mGluR5 macrophages) and non-modified macrophages (RAW-macrophages) has shown that the RAW-mGluR5 macrophages absorbed more glutamate than control cells and the amount of intracellular glutamate correlated with the expression of excitatory amino acid transporters -2 (EAAT-2)...
February 14, 2017: Biological Research
https://www.readbyqxmd.com/read/28186988/hmgb1-targeting-by-ethyl-pyruvate-suppresses-malignant-phenotype-of-human-mesothelioma
#7
Laura Pellegrini, Jiaming Xue, David Larson, Sandra Pastorino, Sandro Jube, Kelly H Forest, Zeyana Salim Saad-Jube, Andrea Napolitano, Ian Pagano, Vishal S Negi, Marco E Bianchi, Paul Morris, Harvey I Pass, Giovanni Gaudino, Michele Carbone, Haining Yang
Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression. Moreover, we demonstrated that targeting HMGB1 inhibited MM cell growth and motility in vitro, reduced tumor growth in vivo, and prolonged survival of MM-bearing mice. Ethyl pyruvate (EP), the ethyl ester of pyruvic acid, has been shown to be an effective HMGB1 inhibitor in inflammation-related diseases and several cancers...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28183701/association-of-serum-hmgb2-levels-with-in-stent-restenosis-hmgb2-promotes-neointimal-hyperplasia-in-mice-with-femoral-artery-injury-and-proliferation-and-migration-of-vsmcs
#8
Yu Hu He, Xiao Qun Wang, Jian Zhang, Zhu Hui Liu, Wen Qi Pan, Ying Shen, Zheng Bin Zhu, Ling Jie Wang, Xiao Xiang Yan, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding, Lin Lu
OBJECTIVE: In a previous study, we established diabetic and nondiabetic minipig models with coronary artery in-stent restenosis (ISR). Mass spectrometry showed that high-mobility group box (HMGB) 2 level was higher in ISR than in non-ISR tissue from diabetic minipigs. We here investigated whether serum HMGB2 levels were related to ISR in CAD patients. The effect of HMGB2 was evaluated in mice with femoral artery wire injury and in human aortic smooth muscle cells. APPROACH AND RESULTS: From 2513 patients undergoing coronary artery intervention and follow-up angiography at ≈1 year, 262 patients were diagnosed with ISR, and 298 patients with no ISR were randomly included as controls...
February 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28181422/hmgb1-contributes-to-glomerular-endothelial-cell-injury-in-anca-associated-vasculitis-through-enhancing-endothelium-neutrophil-interactions
#9
Chen Wang, Dong-Yuan Chang, Min Chen, Ming-Hui Zhao
Our previous studies demonstrated that high mobility group box-1 (HMGB1), a typical damage-associated molecular pattern (DAMP) protein, is associated with the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Moreover, HMGB1 participates in ANCA-induced neutrophil activation. The current study aimed to investigate whether HMGB1 regulated the interaction between neutrophils and glomerular endothelial cells (GEnC) in the presence of ANCA. Correlation analysis on HMGB1 levels in AAV patients and soluble intercellular cell adhesion molecule-1 (sICAM-1) levels or vascular endothelial growth factor (VEGF) levels, which are markers of endothelial cell activation, was performed...
February 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28179433/il-36-signaling-facilitates-activation-of-the-nlrp3-inflammasome-and-il-23-il-17-axis-in-renal-inflammation-and-fibrosis
#10
Hsi-Hua Chi, Kuo-Feng Hua, Yu-Chuan Lin, Ching-Liang Chu, Chih-Yu Hsieh, Yu-Juei Hsu, Shuk-Man Ka, Yu-Ling Tsai, Feng-Cheng Liu, Ann Chen
IL-36 cytokines are proinflammatory and have an important role in innate and adaptive immunity, but the role of IL-36 signaling in renal tubulointerstitial lesions (TILs), a major prognostic feature of renal inflammation and fibrosis, remains undetermined. In this study, increased IL-36α expression detected in renal biopsy specimens and urine samples from patients with renal TILs correlated with renal function impairment. We confirmed the increased expression of IL-36α in the renal tubular epithelial cells of a mouse model of unilateral ureteral obstruction (UUO) and related cell models using mechanically induced pressure, oxidative stress, or high mobility group box 1...
February 8, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28178212/anti-inflammatory-activity-of-sanghuangporus-sanghuang-mycelium
#11
Wang-Ching Lin, Jeng-Shyan Deng, Shyh-Shyun Huang, Sheng-Hua Wu, Chin-Chu Chen, Wan-Rong Lin, Hui-Yi Lin, Guan-Jhong Huang
Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract of Sanghuangporus sanghuang (SS-1), believed to exhibit antioxidant and anti-inflammatory properties, could be used against the excessive inflammatory response associated with lipopolysaccharides (LPS)-induced ALI in mice and to investigate its possible mechanism of action...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28175983/glycyrrhizin-inhibits-porcine-epidemic-diarrhea-virus-infection-and-attenuates-the-proinflammatory-responses-by-inhibition-of-high-mobility-group-box-1-protein
#12
Chang-Chao Huan, Hua-Xia Wang, Xiang-Xiang Sheng, Rui Wang, Xin Wang, Xiang Mao
Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV) infection, leads to significant economic losses in the swine industry worldwide. In our studies, we found that glycyrrhizin, the major component of licorice root extracts, could moderately inhibit PEDV infection in Vero cells, when analyzed by western blot, qRT-PCR and a plaque formation assay. We also revealed that glycyrrhizin inhibited the entry and replication of PEDV. In addition, we demonstrated that glycyrrhizin decreased the mRNA levels of proinflammatory cytokines...
February 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28167650/alarmins-feel-the-stress
#13
REVIEW
Peleg Rider, Elena Voronov, Charles A Dinarello, Ron N Apte, Idan Cohen
Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the "danger hypothesis," it was recently shown that alarmins can also directly sense and report damage by signaling to the environment when released from live cells undergoing physiological stress, even without loss of subcellular compartmentalization. In this article, we review the involvement of alarmins such as IL-1α, IL-33, IL-16, and high-mobility group box 1 in cellular and physiological stress, and suggest a novel activity of these molecules as central initiators of sterile inflammation in response to nonlethal stress, a function we denote "stressorins...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28167116/therapeutic-potential-of-an-anti-high-mobility-group-box-1-monoclonal-antibody-in-epilepsy
#14
Junli Zhao, Yi Wang, Cenglin Xu, Keyue Liu, Ying Wang, Liying Chen, Xiaohua Wu, Feng Gao, Yi Guo, Junming Zhu, Shuang Wang, Masahiro Nishibori, Zhong Chen
Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1) protein is known to contribute significantly to the generation of seizures. Here, we investigated the therapeutic potential of an anti-HMGB1 monoclonal antibody (mAb) in epilepsy. Anti-HMGB1 mAb attenuated both acute seizure models (maximal electroshock seizure pentylenetetrazole-induced and kindling-induced), and chronic epilepsy model (kainic acid-induced) in a dose-dependent manner. Meanwhile, the anti-HMGB1 mAb also attenuated seizure activities of human brain slices obtained from surgical resection from drug-resistant epilepsy patients...
February 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28164548/high-mobility-group-box-1-protein-enhances-hiv-replication-in-newly-infected-primary-t-cells
#15
Quang D Trinh, Ngan Thi Kim Pham, Kazumasa Fuwa, Kazuhide Takada, Shihoko Komine-Aizawa, Mitsuo Honda, Hiroshi Ushijima, Satoshi Hayakawa
BACKGROUND: High-mobility group box 1 (HMGB1), a DNA-binding protein, has recently been shown to have effects on HIV replication, but the effects are dependent on the cell type and the timing of infection. Using human primary T cells, this study aimed to investigate the role of HMGB1 in HIV-1 replication in newly infected cells. METHODS: Human primary T cells were infected with the HIV-1 LAI (X4) strain and then cultured in the presence of recombinant HMGB1 protein or an anti-HMGB1 antibody at various concentrations...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164547/prognostic-value-of-dynamic-monitoring-of-cellular-immunity-and-hmgb1-in-severe-sepsis-delayed-chronic-inflammation-may-be-the-leading-cause-of-death-in-late-severe-sepsis
#16
Han Yu, Zhijiang Qi, Lianxing Zhao, Rui Shao, Yingying Fang, Chunsheng Li
BACKGROUND: Sepsis is a life-threatening response to infection with a high mortality rate. In order to explore the prognostic value of dynamic monitoring of cellular immunity during late severe sepsis, we assessed levels of Tlymphocyte subsets, the human leukocyte antigen D-related (HLA-DR), and the high mobility group box-1 (HMGB1) protein. METHODS: Study participants included 247 consecutive severe sepsis patients who were admitted to Beijing ChaoYang Hospital's Emergency Intensive Care Unit...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28159794/rifz-amed_0655-is-a-pathway-specific-regulator-for-rifamycin-biosynthesis-in-amycolatopsis-mediterranei
#17
Chen Li, Xinqiang Liu, Chao Lei, Han Yan, Zhihui Shao, Ying Wang, Guoping Zhao, Jin Wang, Xiaoming Ding
: Rifamycin and its derivatives are particularly effective against the pathogenic mycobacteria Mycobacterium tuberculosis and Mycobacterium leprae Although the biosynthetic pathway of rifamycin has been extensively studied in Amycolatopsis mediterranei, little is known about the regulation in rifamycin biosynthesis. Here, an in vivo transposon system was employed to identify genes involved in the regulation of rifamycin production in A. mediterranei U32. Totally, nine rifamycin-defecient mutants were isolated, among which three mutants had the transposon inserted in AMED_0655 (namely rifZ, encoding a LuxR_family regulator)...
February 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28159648/the-role-of-neuroimmune-signaling-in-alcoholism
#18
REVIEW
Fulton T Crews, Colleen J Lawrimore, T Jordan Walter, Leon G Coleman
Alcohol consumption and stress increase brain levels of known innate immune signaling molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol, signaling through Toll-like receptors (TLRs), high-mobility group box 1 (HMGB1), miRNAs, pro-inflammatory cytokines and their associated receptors involved in signaling between microglia, other glia and neurons. Repeated cycles of alcohol and stress cause a progressive, persistent induction of HMGB1, miRNA and TLR receptors in brain that appear to underlie the progressive and persistent loss of behavioral control, increased impulsivity and anxiety, as well as craving, coupled with increasing ventral striatal responses that promote reward seeking behavior and increase risk of developing alcohol use disorders...
February 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28152042/effect-of-pregabalin-administration-upon-reperfusion-in-a-rat-model-of-hyperglycemic-stroke-mechanistic-insights-associated-with-high-mobility-group-box-1
#19
Young Song, Ji-Hae Jun, Eun-Jung Shin, Young-Lan Kwak, Jeon-Soo Shin, Jae-Kwang Shim
Hyperglycemia, which reduces the efficacy of treatments and worsens clinical outcomes, is common in stroke. Ability of pregabalin to reduce neuroexcitotoxicity may provide protection against stroke, even under hyperglycemia. We investigated its protective effect against hyperglycemic stroke and its possible molecular mechanisms. Male Wistar rats administered dextrose to cause hyperglycemia, underwent middle cerebral artery occlusion for 1 h and subsequent reperfusion. Rats were treated with an intraperitoneal injection of 30 mg/kg pregabalin or an equal amount of normal saline at the onset of reperfusion (n = 16 per group)...
2017: PloS One
https://www.readbyqxmd.com/read/28149773/effect-on-proliferation-and-apoptosis-of-retinoblastoma-cell-by-rna-inhibiting-high-mobility-group-protein-box-1-expression
#20
Li-Lun Wang, Yan-Qin Feng, Yu-Hong Cheng
AIM: To investigate the effect of high mobility group protein box-1 (HMGB1) siRNA on proliferation and apoptosis of retinoblastoma (Rb) cells. METHODS: The expression of HMGB1 in Rb cells were detected by real-time polymerase chain reaction (RT-PCR) and Western blot. Chemically synthesized HMGB1 siRNA was transfected into Y79 cells. The inhibitory rate was also examined by RT-PCR and Western blot. After HMGB1 siRNA transfection, the cell proliferation was analyzed by MTT, and cell apoptosis was detected by Caspase-3 active detection kit...
2017: International Journal of Ophthalmology
keyword
keyword
51192
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"