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Aluminum adjuvant vaccine hydroxide

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https://www.readbyqxmd.com/read/29755195/evaluation-of-the-efficacy-of-a-novel-porcine-circovirus-type-2-synthetic-peptide-vaccine
#1
Jiwoon Jeong, Changhoon Park, Seeun Kim, Su-Jin Park, Ikjae Kang, Kee Hwan Park, Chanhee Chae
A novel porcine circovirus type 2 (PCV2) peptide vaccine comprised of a consensus capsid (Cap) protein domain encoded by open reading frame 2 was developed to control PCV2 infection. The efficacy of the vaccine was evaluated against a commercial baculovirus-expressed recombinant PCV2 subunit vaccine based on the Cap protein. The amino acid sequence of this Cap protein was designed based on the alignment of amino acid sequences from different isolates from Europe, North America, and Asia. The vaccine was evaluated in either phosphate-buffered saline or adjuvanted with aluminum hydroxide, cobalt oxide, or liposome...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29713168/curdlan-sulfate-o-linked-quaternized-chitosan-nanoparticles-potential-adjuvants-to-improve-the-immunogenicity-of-exogenous-antigens-via-intranasal-vaccination
#2
Shu Zhang, Shengshi Huang, Lu Lu, Xinlei Song, Pingli Li, Fengshan Wang
Introduction: The development of ideal vaccine adjuvants for intranasal vaccination can provide convenience for many vaccinations. As an ideal intranasal vaccine adjuvant, it should have the properties of assisting soluble antigens to pass the mucosal barrier and potentiating both systemic and mucosal immunity via nasal administration. Methods: By using the advantages of polysaccharides, which can promote both T-helper 1 and 2 responses, curdlan sulfate (CS)- O -(2-hydroxyl)propyl-3-trimethyl ammonium chitosan chloride ( O -HTCC) nanoparticles were prepared by interacting CS with O -HTCC, and the adjuvancy of the nanoparticles was investigated...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29698406/generation-and-characterization-of-a-bivalent-protein-boost-for-future-clinical-trials-hiv-1-subtypes-cr01_ae-and-b-gp120-antigens-with-a-potent-adjuvant
#3
Yingxia Wen, Hung V Trinh, Christine E Linton, Chiara Tani, Nathalie Norais, DeeAnn Martinez-Guzman, Priyanka Ramesh, Yide Sun, Frank Situ, Selen Karaca-Griffin, Christopher Hamlin, Sayali Onkar, Sai Tian, Susan Hilt, Padma Malyala, Rushit Lodaya, Ning Li, Gillis Otten, Giuseppe Palladino, Kristian Friedrich, Yukti Aggarwal, Celia LaBranche, Ryan Duffy, Xiaoying Shen, Georgia D Tomaras, David C Montefiori, William Fulp, Raphael Gottardo, Brian Burke, Jeffrey B Ulmer, Susan Zolla-Pazner, Hua-Xin Liao, Barton F Haynes, Nelson L Michael, Jerome H Kim, Mangala Rao, Robert J O'Connell, Andrea Carfi, Susan W Barnett
The RV144 Phase III clinical trial with ALVAC-HIV prime and AIDSVAX B/E subtypes CRF01_AE (A244) and B (MN) gp120 boost vaccine regime in Thailand provided a foundation for the future development of improved vaccine strategies that may afford protection against the human immunodeficiency virus type 1 (HIV-1). Results from this trial showed that immune responses directed against specific regions V1V2 of the viral envelope (Env) glycoprotein gp120 of HIV-1, were inversely correlated to the risk of HIV-1 infection...
2018: PloS One
https://www.readbyqxmd.com/read/29686670/alum-toll-like-receptor-7-adjuvant-enhances-the-expansion-of-memory-b-cell-compartment-within-the-draining-lymph-node
#4
Hoa Thi My Vo, Barbara Christiane Baudner, Stefano Sammicheli, Matteo Iannacone, Ugo D'Oro, Diego Piccioli
Vaccination is one of the most cost-effective health interventions and, with the exception of water sanitization, no other action has had such a major effect in mortality reduction. Combined with other approaches, such as clean water, better hygiene, and health education, vaccination contributed to prevent millions of cases of deaths among children under 5 years of age. New or improved vaccines are needed to fight some vaccine-preventable diseases that are still a threat for the public health globally, as reported also in the Global Vaccine Action Plan (GVAP) endorsed by the World Health Assembly in 2012...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29682589/parenterally-administered-norovirus-gii-4-virus-like-particle-vaccine-formulated-with-aluminum-hydroxide-or-monophosphoryl-lipid-a-adjuvants-induces-systemic-but-not-mucosal-immune-responses-in-mice
#5
Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic
Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since NoV is an enteric pathogen, it is likely that mucosal immunity has a significant role in protection from infection in the intestine. Due to the fact that IM delivery of NoV VLPs does not generate mucosal immunity, we investigated whether NoV genotype GII.4 VLPs coadministered with aluminum hydroxide (Al(OH)3 ) or monophosphoryl lipid A (MPLA) would induce mucosal antibodies in mice...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29660190/safety-and-immunogenicity-of-hbai20-hepatitis-b-vaccine-in-healthy-na%C3%A3-ve-and-non-responding-adults
#6
Özgür M Koc, Paul H M Savelkoul, Inge H M van Loo, Andrea Peeters, Astrid M L Oude Lashof
Approximately 5% of the healthy adult population respond inadequately to the commercial recombinant hepatitis B vaccines. As the recombinant vaccines all have an aluminum-based adjuvant, we tried to enhance the immune response by adding a cytokine-based adjuvant. This new adjuvant AI20, containing 20μg recombinant human IL-2 attached to 20μg aluminum hydroxide, was added to HBVaxPro©-10μg (HBAI20). In a double-blind randomized controlled trial (RCT), 24 naïve subjects were randomized to receive either HBAI20 or commercial HBVaxPro©-10μg vaccine...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29657407/intranasal-administration-of-inactivated-avian-influenza-virus-of-h5n1-subtype-vaccine-induced-systemic-immune-response-in-chicken-and-mice
#7
I N Suartha, G A A Suartini, I W Wirata, N M A R K Dewi, G N N Putra, G A Y Kencana, G N Mahardika
Aim: The need for non-parenteral administration of inactivated avian influenza virus of H5N1 subtype (AIV-H5N1) vaccine is paramount. Here, we provide preliminary data on the immune response of chicken and mice after intranasal administration of AIV-H5N1-inactivated vaccine with ISCOMS, Inmunair (INM), and combined ISCOMS and INM as an adjuvant. Materials and Methods: The AIV isolate of A/Chicken/Denpasar/01/2004 (H5N1) was cultivated in specific pathogen-free chicken eggs and inactivated with formaldehyde...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29610257/comparison-of-immunogenicity-and-protection-of-two-pneumococcal-protein-vaccines-based-on-psaa-and-pspa
#8
Jinfei Yu, Bo Li, Xiaorui Chen, Jingcai Lu, Dandan Wang, Tiejun Gu, Wei Kong, Yongge Wu
Streptococcus pneumoniae is a major cause of invasive pneumococcal disease, septicemia, and meningitis that can result in high morbidity rates in children under 5 years old. The current polysaccharide-based vaccines can provide type-specific immunity, but a broad-spectrum vaccine would provide greater coverage. Therefore, developing pneumococcal-protein-based vaccines that can extend to more serum types is highly important. In this study, we vaccinated mice via the subcutaneous (s.c.) route with a systemic vaccine that is a mixture of fusion protein PsaA-PspA23 and a single protein, PspA4, with aluminum hydroxide as an adjuvant...
June 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29592962/microcrystalline-tyrosine-and-aluminum-as-adjuvants-in-allergen-specific-immunotherapy-protect-from-ige-mediated-reactivity-in-mouse-models-and-act-independently-of-inflammasome-and-tlr-signaling
#9
Deborah S Leuthard, Agathe Duda, Sandra N Freiberger, Sina Weiss, Isabella Dommann, Gabriele Fenini, Emmanuel Contassot, Matthias F Kramer, Murray A Skinner, Thomas M Kündig, Matthew D Heath, Pål Johansen
Allergen immunotherapy (AIT) is the only modality that can modify immune responses to allergen exposure, but therapeutic coverage is low. One strategy to improve AIT safety and efficacy is the use of new or improved adjuvants. This study investigates immune responses produced by microcrystalline tyrosine (MCT)-based vaccines as compared with conventional aluminum hydroxide (alum). Wild-type, immune-signaling-deficient, and TCR-transgenic mice were treated with different Ags (e.g., OVA and cat dander Fel d 1), plus MCT or alum as depot adjuvants...
March 28, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29555220/expression-and-characterization-of-a-novel-truncated-rotavirus-vp4-for-the-development-of-a-recombinant-rotavirus-vaccine
#10
Yijian Li, Miaoge Xue, Linqi Yu, Guoxing Luo, Han Yang, Lianzhi Jia, Yuanjun Zeng, Tingdong Li, Shengxiang Ge, Ningshao Xia
The outer capsid protein VP4 is an important target for the development of a recombinant rotavirus vaccine because it mediates the attachment and penetration of rotavirus. Due to the poor solubility of full-length VP4, VP8 was explored as candidate rotavirus vaccines in the past years. In previous studies, it has been found that the N-terminal truncated VP8 protein, VP8-1 (aa26-231), could be expressed in soluble form with improved immunogenicity compared to the core of VP8 (aa65-223). However, this protein stimulated only a weak immune response when aluminum hydroxide was used as an adjuvant...
March 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29554479/aluminum-hydroxide-colloid-vaccine-encapsulated-in-yeast-shells-with-enhanced-humoral-and-cellular-immune-responses
#11
Hui Liu, Zhenghu Jia, Chengmao Yang, Mei Song, Zhe Jing, Yapu Zhao, Zhenzhou Wu, Liqing Zhao, Dongsheng Wei, Zhinan Yin, Zhangyong Hong
Aluminum salt (Alum) is one of the most important immune adjuvants approved for use in humans, however it is not suitable for vaccination against various chronic infectious diseases and cancers for not being able to induce cell-mediated (Th1) immunity. Here, we encapsulated an Alum colloid inside β-glucan particles (GPs), which are a type of natural particles derived from the yeast glucan shells, to prepare hybrid GP-Alum (GP-Al) adjuvant particles with a very uniform size of 2-4 μm. These hybrid particles can be used to load antigen proteins through a simple mixing procedure, and can be highly specifically targeted to antigen-presenting cells (APCs) and strongly activate dendritic cells (DCs) maturation and cytokine secretion...
March 12, 2018: Biomaterials
https://www.readbyqxmd.com/read/29525280/vaccination-of-sheep-with-quil-a%C3%A2-adjuvant-expands-the-antibody-repertoire-to-the-fasciola-mf6p-fhhdm-1-antigen-and-administered-together-impair-the-growth-and-antigen-release-of-flukes
#12
Ricardo A Orbegozo-Medina, Victoria Martínez-Sernández, Marta González-Warleta, José Antonio Castro-Hermida, Mercedes Mezo, Florencio M Ubeira
Fasciolosis continues to be a major cause of economic losses in the livestock industry and a growing threat to humans. The limited spectrum of effective anthelmintics and the appearance of resistances urge the need for developing an effective vaccine. Most studies have been focused on the use of TH1 -polarizing adjuvants and the use of recombinant Fasciola critical molecules and, despite the efforts, no reproducible protections have been achieved. The F. hepatica MF6p/FhHDM-1 protein is a heme-binding protein also reported to have immunomodulatory properties, constituting a promising target for vaccination and/or as target for the development of new flukicides...
April 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29513692/vaccination-of-lambs-against-haemonchus-contortus-with-the-recombinant-rhc23-effect-of-adjuvant-and-antigen-dose
#13
María Elena González-Sánchez, Montserrat Cuquerella, José M Alunda
Haemonchus contortus is the most pathogenic gastrointestinal helminth of small ruminants. Natural or experimental repeated infections and several native antigens confer a partially protective immune response but vaccination with subunit antigens has been elusive. Promising results have been obtained with a recombinant form of a somatic antigen (rHc23). In this paper we present the results obtained in vaccination trials in lambs using two dosages of rHc23 and standard adjuvants. Six-months old Manchego females lambs were vaccinated with rHc23 (50 or 200 μg/dose) adjuvanted with 1mL aluminum hydroxide on days -42, -28 and -14 or with 200 μg/dose rHc23 and 5 mg Quil A on days -49, -28 and -7...
2018: PloS One
https://www.readbyqxmd.com/read/29510253/aluminum-adjuvant-potentiates-gilthead-seabream-immune-responses-but-induces-toxicity-in-splenic-melanomacrophage-centers
#14
Jorge Galindo-Villegas, Alicia García-Alcazar, José Meseguer, Victoriano Mulero
A key goal of a successful vaccine formulation is the strong induction of persistent protective immune responses without producing side-effects. Adjuvants have been proved to be successful in several species at inducing increased immune responses against poorly immunogenic antigens. Fish are not the exception and promising results of adjuvanted vaccine formulations in many species are needed. In this study, over a period of 300 days, we characterized the apparent damage and immune response in gilthead seabream immunized by intraperitoneal injection with the model antigen keyhole limpet hemocyanin (KLH) alone or formulated with Montanide ISA water-in-oil (761 or 763), or Imject™ aluminum hydroxide (aluminium), as adjuvants...
March 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29455539/immunological-evaluation-of-chitosan-nanoparticles-loaded-with-tetanus-toxoid
#15
M Ghalavand, M Saadati, A Ahmadi, E Abbasi, J Salimian
OBJECTIVES: The present study was aimed at comparing tetanus toxoid (TT)‑loaded-chitosan nanoparticles with aluminum hydroxide as a common vaccine adjuvant. BACKGROUND: Tetanus remains to be a major public health problem. Nanoparticles have been extensively used as immune adjuvants. Tetanus toxoid (TT) encapsulated in chitosan nanoparticles is considered to be a promising tetanus vaccine candidate. METHODS: TT‑loaded chitosan nanoparticles were prepared by the ionic gelation method...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29432824/immune-response-to-antigen-adsorbed-to-aluminum-hydroxide-particles-effects-of-co-adsorption-of-alf-or-alfq-adjuvant-to-the-aluminum-antigen-complex
#16
Zoltan Beck, Oscar B Torres, Gary R Matyas, David E Lanar, Carl R Alving
Aluminum salts have been used as vaccine adjuvants for >50 years, and they are currently present in at least 146 licensed vaccines worldwide. In this study we examined whether adsorption of Army Liposome Formulation (ALF) to an aluminum salt that already has an antigen adsorbed to it might result in improved immune potency of the aluminum-adsorbed antigen. ALF is composed of a family of anionic liposome-based adjuvants, in which the liposomes contain synthetic phospholipids having dimyristoyl fatty acyl groups, cholesterol and monophosphoryl lipid A (MPLA)...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29421216/the-preparation-and-physicochemical-characterization-of-aluminum-hydroxide-tlr7a-a-novel-vaccine-adjuvant-comprising-a-small-molecule-adsorbed-to-aluminum-hydroxide
#17
Padma Malyala, Donatello Laera, Simona Cianetti, Simone Bufali, Marianna Aggravi, Elvira Ianni, Casey Judge, Gillis Otten, Manmohan Singh, Derek T O' Hagan
Adjuvants are necessary to enable vaccine development against a significant number of challenging pathogens for which effective vaccines are not available. We engineered a novel small-molecule immune potentiator, a benzonaphthyridine agonist targeting toll-like receptor 7 (TLR7), as a vaccine adjuvant. TLR7 agonist (TLR7a) was engineered to be adsorbed onto aluminum hydroxide (AlOH), and the resulting AlOH/TLR7a was evaluated as a vaccine adjuvant. AlOH/TLR7a exploits the flexibility of AlOH formulations, has an application in many vaccine candidates, and induced good efficacy and safety profiles against all tested antigens (bacterial- and viral-derived protein antigens, toxoids, glycoconjugates, and so forth) in many animal models, including nonhuman primates...
February 6, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29375970/turning-the-old-adjuvant-from-gel-to-nanoparticles-to-amplify-cd8-t-cell-responses
#18
Hao Jiang, Qin Wang, Lin Li, Qin Zeng, Hanmei Li, Tao Gong, Zhirong Zhang, Xun Sun
Due to its safety and efficacy, aluminum hydroxide is used as an immune adjuvant in human vaccines for over 80 years. Being a Th2 stimulator, the classical gel-like adjuvant, however, fails to generate CD8+ T cell responses, which are important for cancer vaccines. Here, aluminum hydroxide is turned from gel into nano-sized vaccine carriers AlO(OH)-polymer nanoparticles (APNs) to promote their lymphatic migration. After actively uptaken via scavenger receptor-A by antigen-presenting cells (APCs) resident in lymph nodes (LNs), APNs destabilize lysosomes resulting in efficient cytosolic delivery and cross-presentation of antigens...
January 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29359991/evaluation-of-alum-based-adjuvant-on-the-immunogenicity-of-salmonella-enterica-serovar-typhi-conjugates-vaccines
#19
Erman Tritama, Catur Riani, Indra Rudiansyah, Arip Hidayat, Siti Azizah Kharisnaeni, Debbie Sofie Retnoningrum
The function of adjuvant in maintaining the long-term immune response to Typhoid conjugate vaccine (TCV) was evaluated in. Two TCV products, Vi-DT and Vi-TT, were formulated in either aluminum phosphate (AlPO4 ) or aluminum hydroxide (AlOH) as adjuvants and TCV formulated in phosphate buffer saline were used as controls. In each case, a group of Balb/c mice was injected intramuscularly with two doses of the formulated vaccine at two-week intervals. The anti-Vi IgG responses were monitored by Enzyme-Linked Immunosorbent Assay and the levels of CD4+ T-cells expressing cytokine were characterized using intracellular cytokine staining...
January 23, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29334279/uric-acid-and-the-vaccine-adjuvant-activity-of-aluminium-oxy-hydroxide-nanoparticles
#20
Sachin G Thakkar, Haiyue Xu, Xu Li, Zhengrong Cui
In an effort to improve the adjuvanticity of insoluble aluminium salts, we discovered that the adjuvant activity of aluminium salt nanoparticles is significantly stronger than aluminium salt microparticles, likely related to nanoparticle's stronger ability to directly activate NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome as the nanoparticles are more efficiently taken up by phagocytic cells. Endogenous signals such as uric acid from cell damage or death caused by the cytotoxicity of aluminium salts are thought to indirectly activate inflammasome, prompting us to hypothesise that the potent adjuvant activity of aluminium salt nanoparticles is also related to their ability to stimulate uric acid production...
June 2018: Journal of Drug Targeting
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