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https://www.readbyqxmd.com/read/29158796/radiotherapy-alone-or-concurrent-chemoradiation-for-esophageal-squamous-cell-carcinoma-in-elderly-patients
#1
Lina Zhao, Yongchun Zhou, Haitao Pan, Yutian Yin, Guangjin Chai, Yunfeng Mu, Feng Xiao, Steven H Lin, Mei Shi
Purpose: The reported data of elderly ESCC are rather limited and there is a lack of information to guide treatment decisions for elderly patients with esophageal cancer. This study aims to identify the efficacy and factors for optimal treatment approaches for elderly esophageal squamous cell carcinoma (ESCC) treated with radiotherapy (RT) alone or concurrent chemoradiation (CCRT). Methods: This study included 184 I-III elderly ESCC patients aged ≥70 years treated by oral single agent CCRT (sCCRT) or double agents CCRT (dCCRT) or RT alone at a single institution in China...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29135363/total-and-subtotal-laparoscopic-gastrectomy-for-the-treatment-of-advanced-gastric-cancer-morbidity-and-oncological-outcomes
#2
Stefano Olmi, Riccardo Giorgi, Stefano Piero Bernardo Cioffi, Matteo Uccelli, Roberta Villa, Francesca Ciccarese, Bruno Scotto, Giorgio Castello, Gianluca Legnani, Giovanni Cesana
BACKGROUND: A debate is still surrounding the use of laparoscopic surgery for advanced gastric cancer (AGC) related to doubts about the requirements to satisfy oncologic criteria. The aim of this study is to analyze the oncological results, the intraoperative complications, and the short- and medium-term morbidity and mortality in patients with AGC who underwent subtotal laparoscopic gastrectomy (SLG) or total laparoscopic gastrectomy (TLG) with extended lymphadenectomy. MATERIALS AND METHODS: We reviewed medical records of patients who underwent radical gastrectomy for AGC started laparoscopically with the intent of curative surgery, between July 2007 and October 2015...
November 14, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29132401/meta-analysis-comparing-laparoscopic-versus-open-resection-for-gastric-gastrointestinal-stromal-tumors-larger-than-5%C3%A2-cm
#3
Xiao Lian, Fan Feng, Man Guo, Lei Cai, Zhen Liu, Shushang Liu, Shuao Xiao, Gaozan Zheng, Guanghui Xu, Hongwei Zhang
BACKGROUND: Data on the safety and feasibility of laparoscopic versus open resection for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm are limited. Therefore, the aim of this meta-analysis was to compared laparoscopic and open resection for gastric GISTs larger than 5 cm. METHODS: We perform a literature search on PubMed, the Cochrane Library, and Embase. Review Manage version 5.1 (RevMan 5.1) was used for data analysis. The GRADE profiler software (version 3...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29129435/etirinotecan-pegol-nktr-102-in-third-line-treatment-of-patients-with-metastatic-or-recurrent-non-small-cell-lung-cancer-results-of-a-phase-ii-study
#4
Charu Aggarwal, Roger B Cohen, Eddy Yu, Wei-Ting Hwang, Joshua M Bauml, Evan Alley, Tracey L Evans, Corey J Langer
BACKGROUND: Third-line treatment options are limited for patients with metastatic non-small-cell lung cancer (NSCLC). Etirinotecan pegol (NKTR-102) is a long-acting topoisomerase-I inhibitor. We conducted a single-arm phase II trial to evaluate its efficacy in third-line treatment. PATIENTS AND METHODS: Patients aged ≥ 18 years with histologically proven NSCLC who had received 2 previous systemic therapy regimens, measurable disease, Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1, and adequate end-organ function were eligible...
October 19, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29126579/chest-pain-as-a-manifestation-of-hypokalemia-in-a-pediatric-patient
#5
Jonathan S Schiffman
Patients presenting to the emergency department with chest pain are common and a cause of significant concern to patients and families and physicians alike. The causes of chest pain are myriad. These causes span diverse categories including cardiovascular, respiratory, abdominal and gastrointestinal, musculoskeletal, psychiatric, hematologic and oncologic, and neurologic Thull-Freedman (2010) [1]. These diverse etiologies present a diagnostic and management challenge to the ER physician who is tasked to minimize unnecessary diagnostics while not missing any significant disease...
November 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29121285/non-steroidal-anti-inflammatory-drugs-in-the-oncological-surgical-population-beneficial-or-harmful-a-systematic-review-of-the-literature
#6
J P Cata, C E Guerra, G J Chang, V Gottumukkala, G P Joshi
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesic drugs. Recent studies have indicated a potential beneficial effect on long-term survival outcomes after cancer surgery but a negative impact on anastomotic leaks. The objective of this study was to objectively assess the implications of the perioperative NSAIDs use on anastomotic leaks and cancer recurrence. Methods: We searched PubMed, MEDLINE, Embase and Cochrane Library for publications up to mid-January 2017...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29121235/management-of-an-outbreak-of-exophiala-dermatitidis-bloodstream-infections-at-an-outpatient-oncology-clinic
#7
Amber Marie Vasquez, D Zavasky, N A Chow, L Gade, E Zlatanic, S Elkind, A P Litvintseva, Peter G Pappas, J R Perfect, S G Revankar, S R Lockhart, T M Chiller, J Ackelsberg, S Vallabhaneni
Exophiala (Wangiella) dermatitidis is a dematiaceous fungus that can grow in yeast or mold forms and is typically found in decaying organic matter. It can cause central nervous system disease, particularly in immunocompromised patients, and has been implicated as a respiratory pathogen in cystic fibrosis patients [1,2]. It has also been identified as a colonizer in the gastrointestinal tract [3]. However, bloodstream infections with this organism are exceedingly rare.
November 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29118560/the-effectiveness-of-intravenous-iron-for-iron-deficiency-anemia-in-gastrointestinal-cancer-patients-a-retrospective-study
#8
Laurens Verhaeghe, Luk Bruyneel, Elisabeth Stragier, Marc Ferrante, Daan Dierickx, Hans Prenen
Background: Knowledge of the role of intravenous iron without the use of additional erythropoietic stimulating agents in anemic cancer patients is limited. This study evaluated the effect of ferric carboxymaltose (FCM) in a group of digestive oncology (DIO) patients and aimed to differentiate therapy response according to different types of iron deficiency (ID) anemia. Methods: In this retrospective study, we identified DIO patients who were receiving FCM and had eligible baseline and follow-up hemoglobin (Hb) levels that did not require red blood cell transfusion...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29115938/carbon-ion-radiotherapy-for-80%C3%A2-years-or-older-patients-with-hepatocellular-carcinoma
#9
Shintaro Shiba, Takanori Abe, Kei Shibuya, Hiroyuki Katoh, Yoshinori Koyama, Hirohumi Shimada, Satoru Kakizaki, Ken Shirabe, Hiroyuki Kuwano, Tatsuya Ohno, Takashi Nakano
BACKGROUND: To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) for 80 years or older patients with hepatocellular carcinoma (HCC). METHODS: Eligibility criteria of this retrospective study were: 1) HCC confirmed by histology or typical hallmarks of HCC by imaging techniques of four-phase multidetector-row computed tomography or dynamic contrast-enhanced magnetic resonance imaging; 2) no intrahepatic metastasis or distant metastasis; 3) no findings suggesting direct infiltration of the gastrointestinal tract; 4) performance status ≤2 by Eastern Cooperative Oncology Group classification; and 5) Child-Pugh classification A or B...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29113194/immune-related-adverse-events-during-anticancer-immunotherapy-pathogenesis-and-management
#10
Stefania Stucci, Raffaele Palmirotta, Anna Passarelli, Erica Silvestris, Antonella Argentiero, Laura Lanotte, Silvana Acquafredda, Annalisa Todisco, Franco Silvestris
Immunotherapy is one of the most recent systemic treatments to emerge for use in oncology, and is based on the blocking of inhibitory immune checkpoints to potentiate the immune response to cancer. The anti-cytotoxic T lymphocyte-associated antigen-4 antibody ipilimumab and anti-programmed cell death protein 1 antibodies, including nivolumab and pembrolizumab, are currently available and widely used, and other immune-inhibiting antibodies are now under intensive investigation. These antibodies have shown efficacy in a growing number of tumor types, following initial observations of their notable effects in melanoma treatment...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110271/induced-bias-due-to-crossover-within-randomized-controlled-trials-in-surgical-oncology-a-meta-regression-analysis-of-minimally-invasive-versus-open-surgery-for-the-treatment-of-gastrointestinal-cancer
#11
REVIEW
George Garas, Sheraz R Markar, George Malietzis, Hutan Ashrafian, George B Hanna, Emmanouil Zacharakis, Long R Jiao, Athanassios Argiris, Ara Darzi, Thanos Athanasiou
BACKGROUND: Randomized controlled trials (RCTs) inform clinical practice and have provided the evidence base for introducing minimally invasive surgery (MIS) in surgical oncology. Crossover (unplanned intraoperative conversion of MIS to open surgery) may affect clinical outcomes and the effect size generated from RCTs with homogenization of randomized groups. OBJECTIVES: Our aims were to identify modifiable factors associated with crossover and assess the impact of crossover on clinical endpoints...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29110040/-surgical-strategy-in-multimodal-treatment-of-gastric-and-esophageal-cancer
#12
REVIEW
J Hoeppner
The majority of curatively treatable esophageal and gastric carcinomas are currently diagnosed in a locally advanced stage in Western Europe. The vast majority of patients in Western Europe and the USA are now treated in multimodal treatment protocols. These protocols consist of neoadjuvant chemoradiation or perioperative chemotherapy plus radical surgical resection including lymphadenectomy. Radical esophagectomy and gastrectomy are still the main curative therapeutic step in these  multimodal protocols. The current surgical recommendations and guidelines were, however, based on experience and studies from almost exclusively unimodal treatment of patient groups...
November 6, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29108960/perioperative-morbidity-bowel-function-and-oncologic-outcome-after-radical-cystectomy-and-ileal-orthotopic-neobladder-reconstruction-studer-pouch-versus-i-pouch
#13
Johannes Mischinger, Mohamed F Abdelhafez, Steffen Rausch, Tilman Todenhöfer, Eva Neumann, Stefan Aufderklamm, Arnulf Stenzl, Georgios Gakis
OBJECTIVE: To investigate whether the length of ileum used for ileal orthotopic neobladder (ONB) reconstruction (60 cm vs. 40 cm) after radical cystectomy (RC) for bladder cancer (BC) impacts on bowel function, postoperative complications or survival outcome. MATERIAL AND METHODS: In this retrospective study, we included 56 patients who received an ONB (Studer (S)-Pouch: 23 patients; I-Pouch: 33 patients) after RC for BC between 2003 and 2011. Preoperative comorbidities were assessed by the Charlson Comorbidity Index (CCI) and surgical complications as graded by the Clavien-Dindo classification...
October 20, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29103187/real-world-treatment-patterns-and-effectiveness-among-patients-with-metastatic-colorectal-cancer-treated-with-ziv-aflibercept-in-community-oncology-practices-in-the-usa
#14
Jasmina I Ivanova, Kimberly R Saverno, Jennifer Sung, Mei Sheng Duh, Chen Zhao, Sean Cai, Francis Vekeman, Aaron Peevyhouse, Ravinder Dhawan, Charles S Fuchs
Routine clinical practice data often differ from clinical trials. This study describes real-world treatment patterns and effectiveness among patients with metastatic colorectal cancer (mCRC) receiving ziv-aflibercept in non-academic, community oncology practices in the USA. De-identified electronic medical records from Vector Oncology and Altos Solutions databases were analysed. We identified 218 patients diagnosed with mCRC who had received prior oxaliplatin therapy and initiated ziv-aflibercept as part of second-line or later-line therapy...
November 4, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29074353/clinical-features-of-regorafenib-induced-liver-injury-in-japanese-patients-from-postmarketing-experience
#15
Hiroyuki Uetake, Kenichi Sugihara, Kei Muro, Toshiyuki Sunaya, Yuka Horiuchi-Yamamoto, Hajime Takikawa
BACKGROUND: Regorafenib (Stivarga) is an oral multikinase inhibitor currently approved for patients with metastatic colorectal cancer or gastrointestinal stromal tumor. Although hepatotoxicity has been a known product profile feature of regorafenib since its initial approval, its clinical features are limited to those found in the clinical trials. PATIENTS AND METHODS: The present study was conducted in 2 analysis sets: a safety analysis set for metastatic colorectal cancer from solicited postmarketing surveillance (PMS) in Japan (n = 1227) and an analysis set for serious hepatic adverse drug reactions (n = 210) from all patients registered for regorafenib use...
September 28, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29074079/high-dose-rate-brachytherapy-as-monotherapy-for-localised-prostate-cancer
#16
Iosif Strouthos, Nikolaos Tselis, Georgios Chatzikonstantinou, Saeed Butt, Dimos Baltas, Dimitra Bon, Natasa Milickovic, Nikolaos Zamboglou
BACKGROUND AND PURPOSE: To evaluate the oncological outcome of a three-implant high dose rate (HDR) brachytherapy (BRT) protocol as monotherapy for clinically localised prostate cancer. MATERIAL AND METHODS: Between February 2008 and December 2012, 450 consecutive patients with clinically localised prostate cancer were treated with HDR monotherapy. The cohort comprised of 198 low-, 135 intermediate- and 117 high risk patients being treated with three single-fraction implants of 11...
October 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29071484/robotic-right-colectomy-with-intracorporeal-anastomosis-for-malignancy
#17
Scott R Kelley, Emilie Duchalais, David W Larson
Techniques for robotic resection of the right colon have not been extensively published or adopted. We report our initial experience of robotic right colectomy with intracorporeal anastomosis and specimen extraction through a Pfannenstiel incision retrospectively. Twenty-one consecutive patients with a right colon cancer (n = 18) or polyp too large to remove endoscopically (n = 3) were treated at Mayo Clinic Rochester, Minnesota. Main outcomes measured were estimated blood loss, operative time, conversion rate, return of gastrointestinal function, length of stay, overall and severe complications, discharge status, and pathology...
October 25, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29066337/clostridium-difficile-causing-pediatric-infections-new-findings-from-a-hospital-based-study-in-italy
#18
Patrizia Spigaglia, Fabrizio Barbanti, Elio Castagnola, Maria Cristina Diana, Luisa Pescetto, Roberto Bandettini
Recent studies support a change of Clostridium difficile infections (CDIs) epidemiology in pediatric patients. Since limited information is available about C. difficile in this population, we investigated the epidemiology of CDI in a large pediatric hospital that acts as reference centre in Italy and analyzed C. difficile isolates to identify the prevalent PCR-ribotypes (RTs), the binary toxin (CDT)-positive strains and the antibiotic susceptibility patterns. The CDI incidence was 6.6 cases/1000 admissions and the majority (92%) of CDI were healthcare-associated (47% occurred in the Hematology-Oncology and in the Gastroenterology units)...
October 21, 2017: Anaerobe
https://www.readbyqxmd.com/read/29065378/clinical-relevance-of-molecular-diagnostics-in-gastrointestinal-gi-cancer-european-society-of-digestive-oncology-esdo-expert-discussion-and-recommendations-from-the-17th-european-society-for-medical-oncology-esmo-world-congress-on-gastrointestinal-cancer-barcelona
#19
REVIEW
Alexander Baraniskin, Jean-Luc Van Laethem, Lucjan Wyrwicz, Ulrich Guller, Harpreet S Wasan, Tamara Matysiak-Budnik, Thomas Gruenberger, Michel Ducreux, Fatima Carneiro, Eric Van Cutsem, Thomas Seufferlein, Wolff Schmiegel
BACKGROUND AND SCOPE: In the epoch of precision medicine and personalised oncology, which aims to deliver the right treatment to the right patient, molecular genetic biomarkers are a topic of growing interest. The aim of this expert discussion and position paper is to review the current status of various molecular tests for gastrointestinal (GI) cancers and especially considering their significance for the clinical routine use. METHODOLOGY: Opinion leaders and experts from diverse nationalities selected on scientific merit were asked to answer to a prepared set of questions about the current status of molecular diagnostics in different GI cancers...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29062458/bariatric-surgery-and-incidental-gastrointestinal-stromal-tumors-a-single-center-study-vsj-competition-1-st-place
#20
Maciej Walędziak, Anna Różańska-Walędziak, Piotr K Kowalewski, Michał R Janik, Jakub Brągoszewski, Krzysztof Paśnik
INTRODUCTION: Gastrointestinal stromal tumors (GISTs), originating from Cajal cells, are most commonly located in the stomach; therefore they can be found in the specimens excised during bariatric operations. The global prevalence of GISTs is about 130 cases per million population. Morbidity differs depending on geographical latitude. Although surgery is the treatment of choice for GISTs, 40-50% of patients after radical surgical treatment will have a relapse or metastases. AIM: To analyze the incidence of GISTs in patients undergoing bariatric surgery and to verify whether an operation performed according to the bariatric protocol is oncologically radical in case of GIST...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
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