Loren G Miller, James A McKinnell, Raveena D Singh, Gabrielle M Gussin, Ken Kleinman, Raheeb Saavedra, Job Mendez, Tabitha D Catuna, James Felix, Justin Chang, Lauren Heim, Ryan Franco, Thomas Tjoa, Nimalie D Stone, Karl Steinberg, Nancy Beecham, Jocelyn Montgomery, DeAnn Walters, Steven Park, Steven Tam, Shruti K Gohil, Philip A Robinson, Marlene Estevez, Brian Lewis, Julie A Shimabukuro, Gregory Tchakalian, Aaron Miner, Crystal Torres, Kaye D Evans, Cassiana E Bittencourt, Jiayi He, Eunjung Lee, Christine Nedelcu, Julia Lu, Shalini Agrawal, S Gwynn Sturdevant, Ellena Peterson, Susan S Huang
BACKGROUND: Nursing home residents are at high risk for infection, hospitalization, and colonization with multidrug-resistant organisms. METHODS: We performed a cluster-randomized trial of universal decolonization as compared with routine-care bathing in nursing homes. The trial included an 18-month baseline period and an 18-month intervention period. Decolonization entailed the use of chlorhexidine for all routine bathing and showering and administration of nasal povidone-iodine twice daily for the first 5 days after admission and then twice daily for 5 days every other week...
November 9, 2023: New England Journal of Medicine