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https://www.readbyqxmd.com/read/27852955/microbiological-efficacy-of-early-mrsa-treatment-in-cystic-fibrosis-in-a-randomised-controlled-trial
#1
Marianne Sponer Muhlebach, Valeria Beckett, Elena Popowitch, Melissa B Miller, Arthur Baines, Nicole Mayer-Hamblett, Edith T Zemanick, Wynton C Hoover, Jill M VanDalfsen, Preston Campbell, Christopher H Goss
OBJECTIVE: To evaluate microbiological effectiveness, that is, culture negativity of a non-blinded eradication protocol (Rx) compared with observation (Obs) in clinically stable cystic fibrosis participants with newly positive methicillin resistant Staphylococcus aureus (MRSA) cultures. DESIGN: This non-blinded trial randomised participants ages 4-45 years with first or early (≤2 positive cultures within 3 years) MRSA-positive culture without MRSA-active antibiotics within 4 weeks 1:1 to Rx or Obs...
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27828836/the-impact-of-a-universal-decolonization-protocol-on-hospital-acquired-methicillin-resistant-staphylococcus-aureus-in-a-burn-population
#2
Arthur T Johnson, Rachel M Nygaard, Ellie M Cohen, Ryan M Fey, Anne Lambert Wagner
Hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of HA infections and a significant concern for burn centers. The use of 2% chlorhexidine-impregnated wipes and nasal mupirocin significantly decreases the rate of HA-MRSA in adult intensive care units. The aim of this study was to examine the impact of universal decolonization on the rate of MRSA conversion in an American Burn Association verified adult and pediatric burn center. Universal decolonization protocol consisting of daily chlorhexidine baths and a 5-day course of nasal mupirocin was implemented in the burn unit...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27583685/chlorhexidine-vaginal-wipes-prior-to-elective-cesarean-section-does-it-reduce-infectious-morbidity-a-randomized-trial
#3
Magdy R Ahmed, Nisreen K Aref, Waleed A Sayed Ahmed, Farzana R Arain
OBJECTIVE: To evaluate the efficacy of preoperative vaginal cleansing using chlorhexidine 0.25% antiseptic wipes on rates of postcesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection). METHODS: This prospective randomized trial was conducted among 218 pregnant women scheduled for term elective CS. Patients were equally divided into two groups by simple randomization. After spinal anesthesia and catheterization under aseptic technique, the study group had preoperative vaginal cleansing using chlorhexidine 0...
September 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27528869/predictors-of-staphylococcus-aureus-colonization-and-results-after-decolonization
#4
Tennison L Malcolm, Le Don Robinson, Alison K Klika, Deepak Ramanathan, Carlos A Higuera, Trevor G Murray
Protocols for the screening and decolonization of Staphylococcus aureus prior to total joint arthroplasty (TJA) have become widely adopted. The goals of this study were to determine: (1) whether implementation of a screening protocol followed by decolonization with mupirocin/vancomycin and chlorhexidine reduces the risk of revision compared with no screening protocol (i.e., chlorhexidine alone) and (2) whether clinical criteria could reliably predict colonization with MSSA and/or MRSA. Electronic medical records of primary patients undergoing TJA that were screened (n = 3,927) and were not screened (n = 1,751) for Staphylococcus aureus at least 4 days prior to surgery, respectively, were retrospectively reviewed...
2016: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/27492790/reduction-of-methicillin-resistant-staphylococcus-aureus-infection-in-long-term-care-is-possible-while-maintaining-patient-socialization-a-prospective-randomized-clinical-trial
#5
Lance R Peterson, Susan Boehm, Jennifer L Beaumont, Parul A Patel, Donna M Schora, Kari E Peterson, Deborah Burdsall, Carolyn Hines, Maureen Fausone, Ari Robicsek, Becky A Smith
BACKGROUND: Antibiotic resistance is a challenge in long-term care facilities (LTCFs). The objective of this study was to demonstrate that a novel, minimally invasive program not interfering with activities of daily living or socialization could lower methicillin-resistant Staphylococcus aureus (MRSA) disease. METHODS: This was a prospective, cluster-randomized, nonblinded trial initiated at 3 LTCFs. During year 1, units were stratified by type of care and randomized to intervention or control...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/26956247/does-preadmission-cutaneous-chlorhexidine-preparation-reduce-surgical-site-infections-after-total-knee-arthroplasty
#6
Bhaveen H Kapadia, Peter L Zhou, Julio J Jauregui, Michael A Mont
BACKGROUND: Many preventive methodologies seek to reduce the risk of surgical site infections after total knee arthroplasty (TKA), including the use of preoperative chlorhexidine baths and cloths. Although we have demonstrated in previous studies that this may be an efficacious method for infection prevention, our study was underpowered and we therefore set out to evaluate this with a larger sample size. QUESTIONS/PURPOSES: (1) Does a preadmission chlorhexidine cloth skin preparation protocol decrease the risk of surgical site infection in patients undergoing TKA? (2) When stratified using the National Healthcare Safety Network (NHSN) risk categories, which categories are associated with risk reduction from the preadmission chlorhexidine preparation protocol? METHODS: In our study, all patients (3717 total) who had undergone primary or revision TKA at a single institution between January 1, 2007, and December 31, 2013, were identified, of whom 991 patients used the chlorhexidine cloths before surgery and 2726 patients did not...
July 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26894621/effectiveness-of-chlorhexidine-wipes-for-the-prevention-of-multidrug-resistant-bacterial-colonization-and-hospital-acquired-infections-in-intensive-care-unit-patients-a-randomized-trial-in-thailand
#7
Adhiratha Boonyasiri, Peerapat Thaisiam, Chairat Permpikul, Tepnimitr Judaeng, Bordeesuda Suiwongsa, Napaporn Apiradeewajeset, Teerawan Fakthongphan, Sunun Suddee, Wandee Laoagtipparos, Visanu Thamlikitkul
OBJECTIVE: To determine the effectiveness of daily bathing with 2% chlorhexidine-impregnated washcloths in preventing multidrug-resistant (MDR) gram-positive bacterial colonization and bloodstream infection. METHODS: A randomized, open-label controlled trial was conducted in 4 medical intensive care units (ICUs) in Thailand from December 2013 to January 2015. Patients were randomized to receive cleansing with non-antimicrobial soap (control group) or 2% chlorhexidine-impregnated washcloths used to wipe the patient's body once daily (chlorhexidine group)...
March 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/26876749/management-of-a-hospital-outbreak-of-extensively-drug-resistant-acinetobacter-baumannii-using-a-multimodal-intervention-including-daily-chlorhexidine-baths
#8
A P Gray, R Allard, R Paré, T Tannenbaum, B Lefebvre, S Lévesque, M Mulvey, L Maalouf, S Perna, Y Longtin
BACKGROUND: Extensively drug-resistant Acinetobacter baumannii (XDR-Ab) is an increasingly important cause of healthcare-associated infection. Uncertainties remain concerning optimal control measures for healthcare-associated outbreaks. AIM: To describe the epidemiology and control of an XDR-Ab outbreak that involved multiple units of a large hospital from March 2012 to January 2014. METHODS: Case-finding included screening of rectum, groin, throat, nose, wounds, iatrogenic portals of entry, and catheterized sites...
May 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/26836053/is-staphylococcal-screening-and-suppression-an-effective-interventional-strategy-for-reduction-of-surgical-site-infection
#9
Charles E Edmiston, Nathan A Ledeboer, Blake W Buchan, Maureen Spencer, Gary R Seabrook, David Leaper
BACKGROUND: Staphylococcus aureus has been recognized as a major microbial pathogen for over 100 y, having the capacity to produce a variety of suppurative and toxigenic disease processes. Many of these infections are life-threatening, with particularly enhanced virulence in hospitalized patients with selective risk factors. Strains of methicillin-resistant Staphylococcus aureus (MRSA) have rapidly spread throughout the healthcare environment such that approximately 20% of S. aureus isolates recovered from surgical site infections are methicillin-resistant, (although this is now reducing following national screening and suppression programs and high impact interventions)...
April 2016: Surgical Infections
https://www.readbyqxmd.com/read/26638670/chlorhexidine-to-maintain-cleanliness-of-restroom-door-handles
#10
RANDOMIZED CONTROLLED TRIAL
Holly Young, Zara Plumb, James Stevenson, Annabelle Tibbett, Alexander Rawson, Joseph Thompsett, Mehroze Asif, Mignonne Gunasekara, Thomas Beresford-Peirse, Stuart Miller, Mark Blunt
Restroom internal door handles have the potential to become contaminated by pathogenic bacteria, particularly because frequent breakdowns occur in hand hygiene. Cleaning these door handles periodically could reduce this cross-contamination risk. The sustained effect following cleaning with chlorhexidine could be beneficial in restroom facilities as cleaning episodes are of necessity at time intervals. The cleaning efficacies and residual effects of Sani Cloth CHG 2% wipes were investigated in a double-blinded randomized crossover controlled trial in a school setting...
November 2015: Journal of Environmental Health
https://www.readbyqxmd.com/read/26597632/establishment-of-a-multi-species-biofilm-model-to-evaluate-chlorhexidine-efficacy
#11
R E Touzel, J M Sutton, M E Wand
BACKGROUND: Chronic infections, for example, diabetic foot ulcers, have a large impact in terms of patient morbidity and mortality. These wounds are characterized by complex polymicrobial communities of bacteria, which may include a number of difficult-to-eradicate multidrug-resistant pathogens. AIM: To establish a multi-species biofilm model to test the efficacy of chlorhexidine and chlorhexidine-containing formulas in eradication of polymicrobial biofilms. METHODS: A Centers for Disease Control and Prevention bioreactor was used to establish a multi-species biofilm incorporating Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis with equal numbers of each pathogen...
February 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/26455757/daily-2-chlorhexidine-gluconate-bath-wash-in-a-tertiary-adult-intensive-care-and-high-dependency-units-to-reduce-risk-of-hospital-acquired-multi-resistant-organisms-a-best-practice-implementation-project
#12
REVIEW
Lizanne Dalgleish, Hardeep Jhattu, Judith Streak Gomersall
BACKGROUND: There is growing evidence that the incidence of hospital acquired multi resistant organisms are increasing worldwide. Intensive care patients are particularly prone to hospital-acquired infections. In an effort to combat increasing nosocomial infections rates within the intensive care/high dependency unit setting, Canberra Hospital has implemented a daily 2% chlorhexidine gluconate bath wash in combination as part of a best practice policy to reduce hospital acquired multi resistant organism rates of colonization...
2015: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/26284644/the-impact-of-hospital-acquired-methicillin-resistant-staphylococcus-aureus-in-a-burn-population-after-implementation-of-universal-decolonization-protocol
#13
Arthur T Johnson, Rachel M Nygaard, Ellie M Cohen, Ryan M Fey, Anne Lambert Wagner
Hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of HA infections and a significant concern for burn centers. The use of 2% chlorhexidine-impregnated wipes and nasal mupirocin significantly decreases the rate of HA-MRSA in adult intensive care units. The aim of this study was to examine the impact of universal decolonization on the rate of MRSA conversion in an ABA verified adult and pediatric burn center. Universal decolonization protocol consisting of daily chlorhexidine baths and a 5-day course of nasal mupirocin was implemented in the burn unit...
August 17, 2015: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/26083147/a-pilot-study-of-the-efficacy-of-wipes-containing-chlorhexidine-0-3-climbazole-0-5-and-tris-edta-to-reduce-malassezia-pachydermatis-populations-on-canine-skin
#14
Paola Cavana, Andrea Peano, Jean-Yanique Petit, Paolo Tizzani, Sébastien Perrot, Emmanuel Bensignor, Jacques Guillot
BACKGROUND: Wipes containing chlorhexidine and azole derivates have been recommended for veterinary use. No study has been published about their activity against Malassezia pachydermatis. HYPOTHESIS/OBJECTIVES: To evaluate the in vivo and in vitro activity of wipes soaked in a chlorhexidine, climbazole and Tris-EDTA solution against Malassezia pachydermatis. ANIMALS: Five research colony shar-pei dogs. METHODS: Wipes were applied once daily onto the left axilla, left groin and perianal area (protocol A), and twice daily on the right axilla, right groin and umbilical region (protocol B) for 3 days...
August 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/25973242/impact-of-daily-bathing-with-chlorhexidine-gluconate-on-ventilator-associated-pneumonia-in-intensive-care-units-a-meta-analysis
#15
Wensen Chen, Quan Cao, Songqin Li, Huifen Li, Weihong Zhang
OBJECTIVE: Ventilator associated pneumonia (VAP) is the most important nosocomial infection in intensive care units (ICUs). Our objective was to assess whether daily bathing with chlorhexidine gluconate (CHG) would significantly result in the reduction of VAP. MATERIALS AND METHODS: Meta-analysis of randomized controlled trials (RCTs) and quasi-experimental studies were conducted. The setting are medical, surgical, trauma, and combined medical-surgical ICUs. The patients are adult...
April 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/25699629/modified-protocol-decreases-surgical-site-infections-after-total-knee-arthroplasty
#16
Joseph D Lamplot, Gaurav Luther, Emily Landon Mawdsley, Hue H Luu, David Manning
We investigate the effectiveness of a comprehensive aseptic protocol in reducing surgical site infection (SSI) after knee arthroplasty in a single medical center with a high prevalence of MRSA. A database of all patients in a single center undergoing primary knee arthroplasty between 2005 and 2011 was reviewed for SSI using Centers for Disease Control criteria and AAOS guidelines. All patients were treated with an aseptic protocol consisting of the following: preoperative 2% mupirocin nasal ointment and 0.4% chlorhexidine surgical site wipes, modified instrument care, perioperative prophylactic vancomycin and cefazolin, and surgical site skin preparation with chlorhexidine, alcohol, and iodophor...
October 2015: Journal of Knee Surgery
https://www.readbyqxmd.com/read/25483421/evaluation-of-efficacy-of-skin-cleansing-with-chlorhexidine-in-prevention-of-neonatal-nosocomial-sepsis-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Basudev Gupta, Narain Das Vaswani, Deepak Sharma, Uma Chaudhary, Seema Lekhwani
AIM: The aim of this study was to evaluate the efficacy of skin cleansing with chlorhexidine (CHD) in the prevention of neonatal nosocomial sepsis - a randomized controlled trial. METHODS: This study design was a randomized controlled trial carried out in a tertiary care center of north India. About 140 eligible neonates were randomly allocated to either the subject area group (wiped with CHD solution till day seven of life) or the control group (wiped with lukewarm water)...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25274761/chlorhexidine-gluconate-bathing-to-reduce-methicillin-resistant-staphylococcus-aureus-acquisition
#18
COMPARATIVE STUDY
Ann Petlin, Marilyn Schallom, Donna Prentice, Carrie Sona, Paula Mantia, Kathleen McMullen, Cassandra Landholt
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a virulent organism causing substantial morbidity and mortality in intensive care units. Chlorhexidine gluconate, a topical antiseptic solution, is effective against a wide spectrum of gram-positive and gram-negative bacteria, including MRSA. Objectives To examine the impact of a bathing protocol using chlorhexidine gluconate and bath basin management on MRSA acquisition in 5 adult intensive care units and to examine the cost differences between chlorhexidine bathing by using the bath-basin method versus using prepackaged chlorhexidine-impregnated washcloths...
October 2014: Critical Care Nurse
https://www.readbyqxmd.com/read/25209186/chlorhexidine-in-cosmetic-products-a-market-survey
#19
Morten S Opstrup, Jeanne D Johansen, Rossana Bossi, Michael D Lundov, Lene H Garvey
BACKGROUND: Chlorhexidine may cause type I and type IV allergy. Some chlorhexidine-allergic individuals have been exposed in the healthcare setting as patients or healthcare workers, but for others the source of sensitization is unknown. Chlorhexidine may be used as a preservative or an antimicrobial agent in cosmetic products at a concentration up to 0.3%, as set by the European Cosmetics Directive (now Regulations). OBJECTIVES: To identify cosmetic product types containing chlorhexidine, and to measure the concentration of chlorhexidine in selected products...
January 2015: Contact Dermatitis
https://www.readbyqxmd.com/read/25171975/nasal-photodisinfection-and-chlorhexidine-wipes-decrease-surgical-site-infections-a-historical-control-study-and-propensity-analysis
#20
E Bryce, T Wong, L Forrester, B Masri, D Jeske, K Barr, S Errico, D Roscoe
BACKGROUND: Pre-operative decolonization therapy (DcTx) using chlorhexidine (CHG) body washes and/or intranasal mupirocin can reduce surgical site infections (SSIs), but compliance is often suboptimal. AIM: To assess the effectiveness of immediate DcTx using a novel approach of intranasal antimicrobial photodisinfection therapy (PDT) combined with CHG body wipes for the reduction of SSIs. METHODS: Between 1(st) September 2011 and 31(st) August 2012, 3068 elective cardiac, orthopaedic, spinal, vascular, thoracic and neurosurgical patients were treated with CHG in the 24h preceding surgery, and received intranasal PDT in the pre-operative area...
October 2014: Journal of Hospital Infection
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