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https://www.readbyqxmd.com/read/28208751/oxidative-stress-related-genetic-variants-may-modify-associations-of-phthalate-exposures-with-asthma
#1
I-Jen Wang, Wilfried J J Karmaus
Background: Phthalate exposure may increase the risk of asthma. Little is known about whether oxidative-stress related genes may alter this association. First, this motivated us to investigate whether genetic polymorphisms of the oxidative-stress related genes glutathione S-transferase Mu 1 (GSTM1), glutathione S-transferase pi 1 (GSTP1), superoxide dismutase 2 (SOD2), catalase (CAT), myeloperoxidase (MPO), and EPHX1 in children are associated with phthalate urine concentrations. Second, we addressed the question whether these genes may affect the influence of phthalates on asthma...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28205500/primary-motor-cortex-excitability-is-modulated-during-the-mental-simulation-of-hand-movement
#2
Christian Hyde, Ian Fuelscher, Jarrad A G Lum, Jacqueline Williams, Jason He, Peter G Enticott
OBJECTIVES: It is unclear whether the primary motor cortex (PMC) is involved in the mental simulation of movement [i.e., motor imagery (MI)]. The present study aimed to clarify PMC involvement using a highly novel adaptation of the hand laterality task (HLT). METHODS: Participants were administered single-pulse transcranial magnetic stimulation (TMS) to the hand area of the left PMC (hPMC) at either 50 ms, 400 ms, or 650 ms post stimulus presentation. Motor-evoked potentials (MEPs) were recorded from the right first dorsal interosseous via electromyography...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28205469/valgus-instability-of-the-elbow-due-to-medial-epicondyle-nonunion-treatment-by-fragment-excision-and-medial-collateral-ligament-reconstruction
#3
Yasunori Kaneshiro, Noriaki Hidaka, Koichi Yano, Makoto Fukuda, Hideki Sakanaka
BACKGROUND: The medial epicondyle nonunion becomes symptomatic valgus instability with medial elbow pain and joint instability due to dysfunction of the medial collateral ligament (MCL), thus requiring surgical treatment. The purpose of the present study is to report the clinical result of the fragment excision and ligament reconstruction by free tendon graft in the treatment of symptomatic medial epicondyle nonunion. METHODS: A retrospective study of five consecutive patients was performed...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28197158/overexpression-and-suppression-of-artemisia-annua-4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase-1-gene-aahdr1-differentially-regulate-artemisinin-and-terpenoid-biosynthesis
#4
Dongming Ma, Gui Li, Yue Zhu, De-Yu Xie
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR) catalyzes the last step of the 2-C-methyl-D-erythritol 4- phosphate (MEP) pathway to synthesize isopentenyl pyrophosphate (IPP) and dimethylallyl diphosphate (DMAPP). To date, little is known regarding effects of an increase or a decrease of a HDR expression on terpenoid and other metabolite profiles in plants. In our study, an Artemisia annua HDR cDNA (namely AaHDR1) was cloned from leaves. Expression profiling showed that it was highly expressed in leaves, roots, stems, and flowers with different levels...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28188954/comparative-glandular-trichome-transcriptome-based-gene-characterization-reveals-reasons-for-differential-menthol-biosynthesis-in-mentha-species
#5
Md Qussen Akhtar, Nida Qamar, Pallavi Yadav, Pallavi Kulkarni, Ajay Kumar, Ajit Kumar Shasany
The genes involved in menthol biosynthesis are reported earlier in Mentha × piperita. But the information on these genes is not available in Mentha arvensis. To bridge the gap in knowledge on differential biosynthesis of monoterpenes leading to compositional variation in the essential oil of these species, a comparative transcriptome analysis of the glandular trichome was carried out. In addition to the MVA and MEP pathway genes, about 210 and 196 different terpene synthases (TPS) transcripts were identified from annotation in M...
February 11, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28186673/modulation-of-fronto-parietal-connections-during-the-rubber-hand-illusion
#6
Anke Ninija Karabanov, Anina Ritterband-Rosenbaum, Mark Schram Christensen, Hartwig Roman Siebner, Jens Bo Nielsen
Accumulating evidence suggests that parieto-frontal connections play a role in adjusting body ownership during the Rubber Hand Illusion (RHI). Using a motor version of the rubber hand illusion paradigm, we applied single-site and dual-site transcranial magnetic stimulation (TMS) to investigate cortico-spinal and parietal-frontal connectivity during perceived rubber hand ownership. Healthy volunteers received a conditioning TMS pulse over left anterior intraparietal sulcus (aIPS) and a test TMS pulse over left primary motor cortex (M1)...
February 10, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28185992/lasso-plate-an-original-implant-for-fixation-of-type-i-and-ii-regan-morrey-coronoid-fractures
#7
Pengfei Wang, Yan Zhuang, Zhong Li, Wei Wei, Yahui Fu, Xing Wei, Kun Zhang
INTRODUCTION: Coronoid fractures are notoriously difficult to manage particularly when there is a small fragment. We report a retrospective analysis of our experience with consecutive type I and II Regan-Morrey coronoid fractures using a lasso plate. HYPOTHESIS: Type I and II Regan-Morrey coronoid fractures can be effectively managed using a lasso plate. METHODS: From October, 2011 and December, 2013, 25 patients(21 males and 4 females, mean age 40...
February 6, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28185615/clinical-study-of-neuroregen-scaffold-combined-with-human-mesenchymal-stem-cells-for-the-repair-of-chronic-complete-spinal-cord-injury
#8
Yannan Zhao, Fengwu Tang, Guang Han, Nuo Wang, Na Yin, Bing Chen, Xianfeng Jiang, Chen Yun, Wanjun Han, Changyu Zhao, Shixiang Cheng, Zhifeng Xiao, Sai Zhang, Jianwu Dai
Regeneration of damaged neurons and recovery of sensation and motor function after complete spinal cord injury (SCI) are challenging. We previously developed a collagen scaffold, NeuroRegen scaffold, to promote axonal growth along collagen fibers and inhibit glial scar formation after SCI. When functionalized with multiple biomolecules, this scaffold promoted neurological regeneration and functional recovery in animals with SCI. In this study, eight patients with chronic complete SCI were enrolled to examine the safety and efficacy of implanting NeuroRegen scaffold with human umbilical cord mesenchymal stem cells (MSCs)...
February 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28179557/individual-differences-in-resting-cortico-spinal-excitability-are-correlated-with-reaction-time-and-gaba-content-in-motor-cortex
#9
Ian Greenhouse, Maedbh King, Sean Noah, Richard J Maddock, Richard B Ivry
Individuals differ in the intrinsic excitability of their corticospinal pathways, and perhaps more generally, their entire nervous system. At present, we have little understanding of the mechanisms underlying these differences and how variation in intrinsic excitability relates to behavior. Here, we examined the relationship between individual differences in intrinsic corticospinal excitability, local cortical γ-amino butyric acid (GABA) levels, and reaction time in a group of twenty healthy human adults. We measured corticospinal excitability at rest with transcranial magnetic stimulation, local concentrations of basal GABA with magnetic resonance spectroscopy, and RT with a behavioral task...
February 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28174417/amkl-chimeric-transcription-factors-are-potent-inducers-of-leukemia
#10
J Dang, S Nance, J Ma, J Cheng, M P Walsh, P Vogel, J Easton, G Song, M Rusch, A L Gedman, C Koss, J R Downing, T A Gruber
Acute megakaryoblastic leukemia in patients without Down syndrome is a rare malignancy with a poor prognosis. RNA sequencing of fourteen pediatric cases previously identified novel fusion transcripts that are predicted to be pathologic including CBFA2T3-GLIS2, GATA2-HOXA9, MN1-FLI, and NIPBL-HOXB9. In contrast to CBFA2T3-GLIS2 which is insufficient to induce leukemia, we demonstrate that the introduction of GATA2-HOXA9, MN1-FLI1 or NIPBL-HOXB9 into murine bone marrow induces overt disease in syngeneic transplant models...
February 8, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28174045/urinary-concentrations-of-25-phthalate-metabolites-in-brazilian-children-and-their-association-with-oxidative-dna-damage
#11
Bruno A Rocha, Alexandros G Asimakopoulos, Fernando Barbosa, Kurunthachalam Kannan
Exposure of humans to phthalates has received considerable attention due to the ubiquitous occurrence and potential adverse health effects of these chemicals. Nevertheless, little is known about the exposure of the Brazilian population to phthalates. In this study, concentrations of 25 phthalate metabolites were determined in urine samples collected from 300 Brazilian children (6-14years old). Further, the association between urinary phthalate concentrations and a biomarker of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8OHDG), was examined...
February 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28174042/phthalate-induced-oxidative-stress-and-association-with-asthma-related-airway-inflammation-in-adolescents
#12
Carmen Franken, Nathalie Lambrechts, Eva Govarts, Gudrun Koppen, Elly Den Hond, Daniëlla Ooms, Stefan Voorspoels, Liesbeth Bruckers, Ilse Loots, Vera Nelen, Isabelle Sioen, Tim S Nawrot, Willy Baeyens, Nicolas Van Larebeke, Greet Schoeters
BACKGROUND: In Belgium, around 8.5% of the children have asthmatic symptoms. Increased asthma risk in children has been reported in relation to exposure to phthalate plasticizers but the underlying mechanisms are largely unknown. AIM: The aim of this study was to identify if oxidative stress, assessed by excision of 8-hydroxydeoxyguanosine (8-OHdG) from damaged DNA, is an intermediate marker for the association between phthalate exposure and doctor-diagnosed asthma...
January 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28171772/maternal-prenatal-urinary-phthalate-metabolite-concentrations-and-visual-recognition-memory-among-infants-at-27-weeks
#13
Khristina N Ipapo, Pam Factor-Litvak, Robin M Whyatt, Antonia M Calafat, Diurka Diaz, Frederica Perera, Virginia Rauh, Julie B Herbstman
BACKGROUND: Prior research has demonstrated inverse associations between maternal prenatal urinary phthalate metabolite concentrations and cognitive development assessed in preschool and school-aged children. While there are a limited number of studies that evaluated these associations during infancy, no study has evaluated whether these associations exist when using the Fagan Test of Infant Intelligence (FTII), which captures novelty preference as a function of visual recognition memory...
February 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28168131/radiological-and-functional-outcome-of-medial-epicondyle-fracture-treated-surgically-in-children-and-adolescents-a-retrospective-study
#14
Sagar Panthi, Kishor Khatri, Krishna Kharel, Raju Vaishya, Amit Kumar Agarwal, Vipul Vijay
PURPOSE: Fractures of the medial humeral epicondyle represent approximately 10% of all pediatric elbow fractures. Surgically treated pediatric fractures of the medial humeral epicondyle were analyzed retrospectively for their epidemiological, clinical, radiological and surgical parameters. The evaluation includes the Mayo elbow performance score (MEPS). METHODS: Twenty-five surgically treated fractures of the medial humeral epicondyle were analyzed...
January 4, 2017: Curēus
https://www.readbyqxmd.com/read/28166167/stepwise-percutaneous-leverage-technique-to-avoid-posterior-interosseous-nerve-injury-in-pediatric-radial-neck-fracture
#15
Wan-Sun Choi, Kyeong-Jin Han, Doo-Hyung Lee, Ga-Eun Lee, Heon-Ju Kweon, Jae-Ho Cho
OBJECTIVES: To introduce a stepwise percutaneous leverage technique to avoid posterior interosseous nerve (PIN) injury in pediatric patients with radial neck fractures and to evaluate the clinical outcome and the predisposing factors affecting the outcome. DESIGN: Retrospective case series study. SETTING: University level 1 trauma center. PATIENTS: Thirty-four children with a radial neck fracture, who were treated using a stepwise percutaneous leverage technique, were included in the study...
January 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28163678/primary-motor-cortex-activation-during-action-observation-of-tasks-at-different-video-speeds-is-dependent-on-movement-task-and-muscle-properties
#16
Takefumi Moriuchi, Daiki Matsuda, Jirou Nakamura, Takashi Matsuo, Akira Nakashima, Keita Nishi, Kengo Fujiwara, Naoki Iso, Hideyuki Nakane, Toshio Higashi
The aim of the present study was to investigate how the video speed of observed action affects the excitability of the primary motor cortex (M1), as assessed by the size of motor-evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS). Twelve healthy subjects observed a video clip of a person catching a ball (Experiment 1: rapid movement) and another 12 healthy subjects observed a video clip of a person reaching to lift a ball (Experiment 2: slow movement task). We played each video at three different speeds (slow, normal and fast)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28162172/-radiographic-and-clinical-assessment-of-supracondylar-humeral-fractures-resulted-from-sports-in-children
#17
Z J Liu, S N Pan, L J Zhang
Objective: To investigate the radiographic and clinical assessment for supracondylar humeral fractures resulted from sports in children. Methods: The medical records of 166 patients with displaced supracondylar humerus fractures treated in Shengjing Hospital of China Medical University from January 2015 to December 2015 were reviewed.The etiology of 56 of 166 cases was relevant to the sports.Medical records of 56 of 166 patients were reviewed, incluidng gender, the mean age of patient at the time of surgery, the mean duration of injury, radiographic assessment based on the anteroposterior (AP) and lateral radiographs of the elbow, neurologic injury, the Mayo Elbow Performance Score (MEPS) and the criteria of Flynn...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28161015/-electrophysiological-testing-in-spinal-cord-tumors
#18
REVIEW
N André-Obadia, F Mauguière
Evoked potentials (EPs) are useful to evaluate the functional impairment of motor and somatosensory pathways in spinal cord tumors. Conduction through pyramidal tracts is evaluated by motor EPs (MEPs) elicited by transcranial stimulation, magnetic for awake patients or electric in the operating room. Somatosensory EPs (SEPs) and laser EPs (LEPs) are complementary procedures to explore conduction in dorsal columns and spinothalamic tracts, respectively. MEPs as well as SEPs show conduction abnormalities in about 60% of cases with a sensitivity that increases up to 70% when both procedures are carried out...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28160730/characterization-of-criteria-air-pollutants-in-beijing-during-2014-2015
#19
Hao Guo, Yungang Wang, Hongliang Zhang
One year-long criteria air pollutants data collected in Beijing were analyzed in this paper, which can support the research on formation, transport and human health effects of air pollutants. This is the first time to study the spatial and temporal variations of criteria pollutants in Beijing using hourly observational data from 12 sites between June 2014 and May 2015 released by the Ministry of Environmental Protection (MEP) of China. Beijing is facing tremendous air pollution as the daily averaged PM2.5 (particulate matter with aerodynamic diameter less than 2...
February 1, 2017: Environmental Research
https://www.readbyqxmd.com/read/28159637/transcranial-magnetic-stimulation-tms-responses-elicited-in-hindlimb-muscles-as-an-assessment-of-synaptic-plasticity-in-spino-muscular-circuitry-after-chronic-spinal-cord-injury
#20
Hayk A Petrosyan, Valentina Alessi, Sue A Sisto, Mark Kaufman, Victor L Arvanian
Electromagnetic stimulation applied at the cranial level, i.e. transcranial magnetic stimulation (TMS), is a technique for stimulation and neuromodulation used for diagnostic and therapeutic applications in clinical and research settings. Although recordings of TMS elicited motor-evoked potentials (MEP) are an essential diagnostic tool for spinal cord injured (SCI) patients, they are reliably recorded from arm, and not leg muscles. Mid-thoracic contusion is a common SCI that results in locomotor impairments predominantly in legs...
January 31, 2017: Neuroscience Letters
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