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https://www.readbyqxmd.com/read/29775218/unilateral-movement-preparation-causes-task-specific-modulation-of-tms-responses-in-the-passive-opposite-limb
#1
Lilian Chye, Stephan Riek, Aymar de Rugy, Richard G Carson, Timothy J Carroll
Corticospinal excitability is modulated for muscles on both sides of the body during unilateral movement preparation. For the effector, there is a progressive increase in excitability, and a shift in direction of muscle twitches evoked by transcranial magnetic stimulation (TMS) toward the impending movement. By contrast, the directional characteristics of excitability changes in the opposite (passive) limb have not been fully characterized. Here we assessed how preparation of voluntary forces towards four spatially distinct visual targets with the left wrist alters muscle twitches and motor evoked potentials (MEPs) elicited by TMS of left motor cortex...
May 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29773202/impaired-short-term-plasticity-in-restless-legs-syndrome-a-pilot-rtms-study
#2
Giuseppe Lanza, Bartolo Lanuzza, Debora Aricò, Mariagiovanna Cantone, Filomena Irene Ilaria Cosentino, Rita Bella, Giovanni Pennisi, Raffaele Ferri, Manuela Pennisi
BACKGROUND: Previous studies showed an impairment of the LTP-like plasticity to TMS in restless legs syndrome (RLS). Clinically, repetitive TMS (rTMS) was effective in alleviating the sensory-motor complaints of patients, although the effects induced by low-frequency (inhibitory) rTMS have not yet been investigated. An impaired LTD-like mechanism of cortical plasticity has been hypothesized, which we have directly assessed in this pilot study. METHODS: Motor evoked potentials (MEPs) from the right first dorsal interosseus muscle were recorded at the stimulus intensity of 110% of the resting motor threshold (rMT) from 13 right-handed patients and ten age-matched right-handed healthy controls...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29772469/synthesis-of-steroidal-imidazolidinthiones-as-potential-apoptotic-agents-investigation-by-theoretical-and-experimental-studies
#3
Ayaz Mahmood Dar, Rizwan Nabi, Shafia Mir, Manzoor Ahmad Gatoo, Shamsuzzaman, Shabir H Lone
New steroidal imidazolidinthione derivatives (4-6) were synthesized from steroidal thiosemicarbazones and dichloroethane. The synthesized compounds were characterized using spectral data analysis. Theoretical DFT involving B3LYP/6-31G∗∗ level of theory was employed to gain insights into the molecular structure of the target compounds. MEPS and FMO analysis were carried out. HOMO-LUMO energy gap was determined which helped to evaluate various global descriptors like hardness, chemical potential, electronegativity, nucleophilicity and electrophilicity index, etc...
May 2, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29772366/giant-cell-ependymoma-of-cervical-medullary-junction-a-case-report-of-a-long-term-survivor-and-review-of-literature
#4
REVIEW
Martina Cappelletti, Andrea G Ruggeri, Giorgia Iacopino, Roberto Delfini
Ependymoma accounts for 3-9% of all neuroepithelial tumors. The giant cell ependymoma is a rare and distinct variant, of which only twenty-two cases have been described in literature. Starting from 2007, the WHO acknowledged this rare subtype. The cytological features of GCE are the presence of pleomorphic giant cells with several cellular atypias, which at intra-operative frozen diagnosis may appear to be high-grade glial lesions. Despite its apparently malignant histology, GCE seems to be a neoplasm with a relatively good prognosis...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771999/growth-medium-dependent-antimicrobial-activity-of-early-stage-mep-pathway-inhibitors
#5
Sara Sanders, David Bartee, Mackenzie J Harrison, Paul D Phillips, Andrew T Koppisch, Caren L Freel Meyers
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathways. In one such pathway, the methylerythritol phosphate (MEP) pathway, which is essential for production of isoprenoids in bacterial pathogens, relatively little is known about the influence of growth environment on antibacterial properties of inhibitors targeting enzymes in this pathway...
2018: PloS One
https://www.readbyqxmd.com/read/29771008/dianionic-titanyl-and-vanadyl-cation-2-m-iv-o-pc-4-2-phthalocyanine-salts-containing-pc-4-macrocycles
#6
Dmitri V Konarev, Alexey V Kuzmin, Salavat S Khasanov, Alexey L Litvinov, Akihiro Otsuka, Hideki Yamochi, Hiroshi Kitagawa, Rimma N Lyubovskaya
In this study, the titanyl and vanadyl phthalocyanine (Pc) salts (Bu4 N+ )2 [MIV O(Pc4- )]2- (M=Ti, V) and (Bu3 MeP+ )2 [MIV O(Pc4- )]2- (M=Ti, V) with [MIV O(Pc4- )]2- dianions were synthesized and characterized. Reduction of MIV O(Pc2- ) carried out with an excess of sodium fluorenone ketyl in the presence of Bu4 N+ or Bu3 MeP+ is exclusive to the phthalocyanine centers, forming Pc4- species. During reduction, the metal +4 charge did not change, implying that Pc is an non-innocent ligand. The Pc negative charge increase caused the C-N(pyr) bonds to elongate and the C-N(imine) bonds to alternate, thus increasing the distortion of Pc...
May 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29769065/prevalence-patterns-and-predictors-of-depression-treatment-among-community-dwelling-older-adults-with-stroke-in-the-united-states-a-cross-sectional-study
#7
Sandipan Bhattacharjee, Majed Al Yami, Sawsan Kurdi, David Rhys Axon
BACKGROUND: Depression is one of the most common psychiatric conditions among stroke survivors and is associated with several negative health outcomes. However, little is known about the depression treatment patterns among stroke survivors. The objective of this study was to examine national-level prevalence, patterns and predictors of depression treatment among community-dwelling stroke survivors. METHODS: This study adopted a retrospective, cross-sectional study design using multiple years of Medical Expenditure Panel Survey (MEPS) (2002-2012) data...
May 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29766712/highly-sensitive-membrane-based-pressure-sensors-meps-for-real-time-monitoring-of-catalytic-reactions
#8
Alessandra Zizzari, Monica Bianco, Loretta L Del Mercato, Antonio Sorarù, Mauro Carraro, Paolo Pellegrino, Elisabetta Perrone, Anna Grazia Monteduro, Marcella Bonchio, Rosaria Rinaldi, Ilenia Viola, Valentina Arima
Functional, flexible and integrated lab-on-chips, based on elastic membranes, are capable of fine response to external stimuli, so to pave the way for many applications as multiplexed sensors for a wide range of chemical, physical and biomedical processes. Here, we report on the use of elastic thin membranes (TMs), integrated with a reaction chamber, to fabricate a Membrane-based Pressure Sensor (MePS) for reaction monitoring. In particular, the TM becomes the key-element in the design of a highly sensitive MePS capable to monitor gaseous species production in dynamic and temporally fast processes with high resolution and reproducibility...
May 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29766355/early-functional-mri-activation-predicts-motor-outcome-after-ischemic-stroke-a-longitudinal-multimodal-study
#9
Juan Du, Fang Yang, Zhiqiang Zhang, Jingze Hu, Qiang Xu, Jianping Hu, Fanyong Zeng, Guangming Lu, Xinfeng Liu
An accurate prediction of long term outcome after stroke is urgently required to provide early individualized neurorehabilitation. This study aimed to examine the added value of early neuroimaging measures and identify the best approaches for predicting motor outcome after stroke. This prospective study involved 34 first-ever ischemic stroke patients (time since stroke: 1-14 days) with upper limb impairment. All patients underwent baseline multimodal assessments that included clinical (age, motor impairment), neurophysiological (motor-evoked potentials, MEP) and neuroimaging (diffusion tensor imaging and motor task-based fMRI) measures, and also underwent reassessment 3 months after stroke...
May 15, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29765890/intraoperative-monitoring-of-hypoglossal-nerve-using-hypoglossal-motor-evoked-potential-in-infratentorial-tumor-surgery-a-report-of-two-cases
#10
Seung Yeun Kim, Hyo Won Im, Young-Doo Choi, Keewon Kim, Jin Wook Kim, Yong Hwy Kim, Han Gil Seo
The hypoglossal nerve (CN XII) may be placed at risk during posterior fossa surgeries. The use of intraoperative monitoring (IOM), including the utilization of spontaneous and triggered electromyography (EMG), from tongue muscles innervated by CN XII has been used to reduce these risks. However, there were few reports regarding the intraoperative transcranial motor evoked potential (MEP) of hypoglossal nerve from the tongue muscles. For this reason, we report here two cases of intraoperative hypoglossal MEP monitoring in brain surgery as an indicator of hypoglossal deficits...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29760645/systems-analysis-of-human-visuo-myoelectric-control-facilitated-by-anodal-transcranial-direct-current-stimulation-in-healthy-humans
#11
Vinh Kha, Aguida S Foerster, Susan Bennett, Michael A Nitsche, Filip Stefanovic, Anirban Dutta
Induction of neuroplasticity by transcranial direct current stimulation (tDCS) applied to the primary motor cortex facilitates motor learning of the upper extremities in healthy humans. The impact of tDCS on lower limb functions has not been studied extensively so far. In this study, we applied a system identification approach to investigate the impact of anodal transcranial direct current stimulation of the leg area of the motor cortex via the human visuo-myoelectric controller. The visuo-myoelectric reaching task (VMT) involves ballistic muscle contraction after a visual cue...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29759252/simultaneous-determination-of-quercetin-and-its-metabolites-in-rat-plasma-by-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#12
Veronika Pilařová, Kateřina Plachká, Lucia Chrenková, Iveta Najmanová, Přemysl Mladěnka, František Švec, Ondřej Novák, Lucie Nováková
Fast, selective, and sensitive ultra-high performance liquid chromatography method with tandem mass spectrometry detection for the determination of quercetin and its metabolites with various physico-chemical properties such as molecular weight, lipophilicity, and acid-base properties has been developed. These compounds included small hydrophilic phenolic acids and more lipophilic metabolites with preserved flavonoid structure in small amount of rat plasma. The developed method enables selective separation of phenolic acids and a pair of isomers tamarixetin and isorhamnetin with satisfactory peak shapes and a high sensitivity using mass spectrometry detection...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759026/efficacy-of-oligodendrocyte-progenitor-cell-transplantation-in-rat-models-with-traumatic-thoracic-spinal-cord-injury-a-systematic-review-and-meta-analysis
#13
Haitao Fu, Die Hu, Licheng Zhang, Xuezhen Shen, Peifu Tang
Spinal cord injury (SCI) is a devastating disease that results in severe motor, sensory, and autonomic dysfunction, for which there is currently no available treatments. Following the primary mechanical damage, progressive secondary damage further exacerbates the functional deficit. Demyelination may play an important role in the pathogenesis of SCI. Oligodendrocyte progenitor cells (OPCs) are considered a candidate cellular treatment approach for SCI due to their unique potential. Here, we conducted a systematic review and meta-analysis to assess the efficacy of OPC transplantation in rat models with traumatic thoracic SCI and 17 studies (20 experiments, 402 rats) were identified...
May 15, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29758868/environmental-incidents-in-china-lessons-from-2006-to-2015
#14
Guozhi Cao, Lei Yang, Lingxuan Liu, Zongwei Ma, Jinnan Wang, Jun Bi
Environmental incidents are among the most significant environmental challenges in China. Hundreds of environmental incidents occur every year, endangering human health and ecosystems. In this paper, we conducted an analytical study of environmental incidents from 2006 to 2015 in China. We first examined the spatiotemporal characteristics of the total 5213 incidents based on the statistical data collected from the China Statistical Yearbook on Environment. We then examined the characteristics of the sources of risk, causes of harm and resulting damage of environmental incidents based on first-hand data from 1369 cases collected by the Ministry of Environmental Protection (MEP) of China, which obtains detailed incident information...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29757044/comparison-of-mental-health-outcomes-among-adults-with-psoriasis-on-biologic-versus-oral-therapies-a-population-based-study
#15
Nicole Salame, Nazanin Ehsani-Chimeh, April W Armstrong
PURPOSE: We sought to compare the impact of biologic versus oral therapies on mental health outcomes among adult U.S. residents with moderate-to-severe psoriasis. METHODS: We performed a nationwide, cross-sectional study comparing 2,303,534 (weighted) adults with moderate-to-severe psoriasis on biologic versus oral therapies and their associated mental health outcomes using the 2003-2015 Medical Expenditure Panel Survey (MEPS). Mental health outcomes were measured with the Kessler 6 (K6), a validated measure of psychological distress, and Patient Health Questionnaire 2 (PHQ2), a screening tool for depression...
May 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29755590/wide-pulse-high-frequency-low-intensity-neuromuscular-electrical-stimulation-has-potential-for-targeted-strengthening-of-an-intrinsic-foot-muscle-a-feasibility-study
#16
Darren C James, Matthew C Solan, Katya N Mileva
Background: Strengthening the intrinsic foot muscles is a poorly understood and largely overlooked area. In this study, we explore the feasibility of strengthening m . abductor hallucis (AH) with a specific paradigm of neuromuscular electrical stimulation; one which is low-intensity in nature and designed to interleave physiologically-relevant low frequency stimulation with high-frequencies to enhance effective current delivery to spinal motoneurones, and enable a proportion of force produced by the target muscle to be generated from a central origin...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29755494/transcription-factor-smwrky1-positively-promotes-the-biosynthesis-of-tanshinones-in-salvia-miltiorrhiza
#17
Wenzhi Cao, Yao Wang, Min Shi, Xiaolong Hao, Weiwei Zhao, Yu Wang, Jie Ren, Guoyin Kai
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive. In this study, one WRKY transcription factor SmWRKY1 was isolated and functionally characterized from S. miltiorrhiza . Multiple sequence alignment and phylogenetic tree analysis showed SmWRKY1 shared high homology with other plant WRKYs such as CrWRKY1. SmWRKY1 was found predominantly expressed in leaves and stems, and was responsive to salicylic acid (SA), methyl jasmonate (MeJA), and nitric oxide (NO) treatment...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29753579/a-reappraisal-of-pain-paired-associative-stimulation-suggesting-motor-inhibition-at-spinal-level
#18
Martine Gavaret, Samar S Ayache, Veit Mylius, Alaa Mhalla, Moussa A Chalah, Jean-Pascal Lefaucheur
OBJECTIVES: Paired associative stimulation (PAS) can modulate motor excitability and consists of delivering repeated pairs of peripheral sensory stimulation combined with transcranial magnetic stimulation (TMS) over the contralateral motor cortex. Our objective was to evaluate the effect of a PAS protocol using a painful stimulation. METHODS: Ten healthy volunteers underwent pain-PAS protocol consisting of 90 pairs of nociceptive stimulus over the right hand followed by an image-guided navigated TMS of the contralateral motor cortex, delivered at 0...
May 9, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29752151/prospective-outcome-assessment-of-arthroscopic-arthrolysis-for-traumatic-and-degenerative-elbow-contracture
#19
Przemysław Lubiatowski, Marta Ślęzak, Joanna Wałecka, Maciej Bręborowicz, Leszek Romanowski
BACKGROUND: The purpose of this study was to evaluate the efficacy of arthroscopic elbow release for both traumatic and degenerative contractures from intraoperative recording through the recovery time until final follow-up. METHODS: The study is based on 54 consecutive patients with extrinsic elbow contracture (traumatic in 31 and degenerative in 23) treated with arthroscopic arthrolysis by a single surgeon in 2011-2015. Range of motion (ROM) and the Mayo Elbow Performance Score (MEPS) were recorded preoperatively; intraoperatively; following release; and in the 1st, 3rd, 8th, 12th, and 26th weeks and at 2 years postoperatively...
May 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29751433/childhood-exposure-to-phthalates-and-pulmonary-function
#20
Liang-Yu Lin, Meng-Shan Tsai, Mei-Huei Chen, Sharon Ng, Chia-Jung Hsieh, Ching-Chun Lin, Frank Leigh Lu, Wu-Shiun Hsieh, Pau-Chung Chen
Phthalate exposure is related to the development of allergic diseases; however, studies regarding its effect on lung function are limited. Our study aims to identify an association between phthalate exposure at different ages and lung function in children at age 9 by conducting a cohort study. The Taiwan Birth Panel Study (TBPS) was established from April 2004 to January 2005. Urine samples were collected from children in the TBPS cohort at ages 2, 5, and 9years. Urinary phthalate metabolite concentrations were measured via ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry...
February 15, 2018: Science of the Total Environment
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