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https://www.readbyqxmd.com/read/28089189/exploring-the-brain-bases-of-dreaming-commentary-on-beyond-the-neuropsychology-of-dreaming-insights-into-the-neural-basis-of-dreaming-with-new-techniques-of-sleep-recording-and-analysis-sleep-medicine-reviews
#1
EDITORIAL
https://www.readbyqxmd.com/read/28074068/a-cpg-island-methylator-phenotype-in-acute-myeloid-leukemia-independent-of-idh-mutations-and-associated-with-a-favorable-outcome
#2
A D Kelly, H Kroeger, J Yamazaki, R Taby, F Neumann, S Yu, J T Lee, B Patel, Y Li, R He, S Liang, Y Lu, M Cesaroni, S A Pierce, S M Kornblau, C E Bueso-Ramos, F Ravandi, H M Kantarjian, J Jelinek, J-Pj Issa
Genetic changes are infrequent in acute myeloid leukemia (AML) compared to other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. In 96 AML cases including 65 pilot samples selected for cured/not-cured, we found higher CpG island (CGI) promoter methylation in cured patients. Expanded genome-wide digital restriction enzyme analysis of methylation (DREAM) data revealed a CGI methylator phenotype independent of IDH1/2 mutations we term AML-CIMP (A-CIMP(+))...
January 11, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28073865/angiogenic-gene-therapy-in-cardiovascular-diseases-dream-or-vision
#3
REVIEW
Seppo Ylä-Herttuala, Charles Bridges, Michael G Katz, Petra Korpisalo
Chronic cardiovascular diseases are significant health problems. Although current treatment strategies have tremendously improved disease management, up to 30% of these patients cannot be successfully treated with current treatment approaches and new treatment strategies are clearly needed. Gene therapy and therapeutic vascular growth may provide a new treatment option for these patients. Several growth factors, like vascular endothelial growth factors, fibroblast growth factors and hepatocyte growth factor have been tested in clinical trials...
January 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28071839/life-after-a-lung-transplant-a-balance-of-joy-and-challenges
#4
Jytte Graarup, Elin Lindberg Mogensen, Malene Missel, Selina Kikkenborg Berg
PURPOSE: To describe patients' experiences throughout the first four months post lung transplant. BACKGROUND: Health professionals are familiar with the fact that patients' average survival after a lung transplant is about seven years and that 74% of these patients reject new organs within the first two years. By contrast, knowledge of these patients' perspectives after lung transplantation is scant. DESIGN/METHOD: A qualitative study was conducted between May, 2013 and May, 2014 in which 26 interviewees participated - four months post-transplant - based on a semi-structured interview guide...
January 10, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28067934/the-end-of-measles-and-congenital-rubella-an-achievable-dream
#5
G Adamo, G Sturabotti, E D'Andrea, V Baccolini, F Romano, S Iannazzo, C Marzuillo, P Villari
BACKGROUND: Despite substantial progress towards measles and rubella control, outbreaks continue to threaten elimination goals worldwide. STUDY DESIGN: This paper aims to document progress towards the global eradication of measles and rubella. In particular, it investigates the major challenges faced by Italy in reaching the elimination goals. METHODS: A review of the most important literature was carried out. Furthermore, a systematic review of the scientific literature on measles and rubella in the Italian setting was performed for the period 2000-2016...
January 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28065945/dream-of-a-conducive-learning-environment-one-dreem-for-all-medical-students
#6
Rehana Rehman, Kulsoom Ghias, Syeda Sadia Fatima, Mehwish Hussain, Faiza Alam
OBJECTIVE: To compare students' response assessed by Dundee Ready Educational Environment Measure on the basis of the year of study, gender and pre-medical educational background. METHODS: This cross-sectional study was carried out at the Aga Khan University Medical College, Karachi, Pakistan, from June 2014 to March 2015, and comprised medical students. The average scores of Dundee Ready Educational Environment Measure scales and subscales were compared between gender and educational background...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28065857/downstream-regulatory-element-antagonist-modulator-a-target-for-anti-thrombotic-agents
#7
Jaehyung Cho
Circulating platelets participate in the process of numerous diseases including thrombosis, inflammation, and cancer. Thus, it is of great importance to understand the underlying mechanisms mediating platelet activation under disease conditions. Emerging evidence indicates that despite the lack of a nucleus, platelets possess molecules that are involved in gene transcription in nucleated cells. This review will summarize downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, and highlight recent findings suggesting its novel non-transcriptional role in hemostasis and thrombosis...
January 5, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28063803/tamoxifen-and-ici-182-780-activate-hypothalamic-g-protein-coupled-estrogen-receptor-1-to-rapidly-facilitate-lordosis-in-female-rats
#8
Nathan Long, Bertha Long, Asma Mana, Dream Le, Lam Nguyen, Sima Chokr, Kevin Sinchak
In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) α and G protein-coupled estrogen receptor 1 (GPER) by estradiol. In the estradiol benzoate (EB) primed ovariectomized (OVX) rat, EB initially binds to ERα in the plasma membrane that complexes with and transactivates metabotropic glutamate receptor 1a to activate β-endorphin neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). This activates MPN μ-opioid receptors (MOP), inhibiting lordosis...
January 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28063723/early-illness-experiences-related-to-unexpected-heart-surgery-a-qualitative-descriptive-study
#9
Yu-Ling Chang, Yun-Fang Tsai
BACKGROUND: Most studies on patients' experiences following emergency cardiac surgery focus on evaluation of patients after their discharge. Few studies have evaluated patients' experiences after being transferred from intensive care and before being discharged. OBJECTIVE: This study aimed to describe patients' experiences in the early stages of recovery following emergency heart surgery. METHODS: For this exploratory qualitative descriptive study, 13 patients were recruited from a medical centre in northern Taiwan...
January 4, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28063022/identification-of-a-syndrome-class-of-neuropsychiatric-adverse-reactions-to-mefloquine-from-latent-class-modeling-of-fda-adverse-event-reporting-system-data
#10
Remington L Nevin, Jeannie-Marie Leoutsakos
INTRODUCTION: Although mefloquine use is known to be associated with a risk of severe neuropsychiatric adverse reactions that are often preceded by prodromal symptoms, specific combinations of neurologic or psychiatric reactions associated with mefloquine use are not well described in the literature. This study sought to identify a distinct neuropsychiatric syndrome class associated with mefloquine use in reports of adverse events. METHODS: Latent class modeling of US Food and Drug Administration Adverse Event Reporting System (FAERS) data was performed using indicators defined by the Medical Dictionary for Regulatory Activities neurologic and psychiatric high-level group terms, in a study dataset of FAERS reports (n = 5332) of reactions to common antimalarial drugs...
January 6, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28059554/searching-for-love-and-test-tube-babies-iraqi-refugee-men-in-reproductive-exile-on-the-margins-of-detroit
#11
Marcia C Inhorn
In this article, I explore the reproductive health problems faced by Iraqi refugees, one of America's most rapidly growing immigrant populations. Based on anthropological research in 'Arab Detroit', the 'capital' of Arab America, I explore the experiences of Iraqi refugee men seeking medical help for their infertility. Most required intracytoplasmic sperm injection (ICSI), a variant of in vitro fertilization (IVF). However, in America's privatized medical system-where a single cycle can cost more than $12,000-few could possibly afford this assisted reproductive technology (ART)...
January 6, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28052330/it-s-only-a-dream-if-you-wake-up-young-adults-achievement-expectations-opportunities-and-meritocratic-beliefs
#12
Jacob Shane, Jutta Heckhausen
The present paper examines university graduates' beliefs about how meritocratic socioeconomic status (SES) attainment in U.S. society is for themselves (merit agency beliefs) and for most other people (merit societal beliefs), and how these distinct beliefs are differentially associated with labour market experiences and achievement-goal attitudes and expectations in the aftermath of the Great Recession. Data from a 10-month longitudinal study of 217 graduates from the 2013 class of a large public U.S. university were analysed using multilevel modelling...
February 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28044015/contextual-modulation-of-primary-visual-cortex-by-auditory-signals
#13
REVIEW
L S Petro, A T Paton, L Muckli
Early visual cortex receives non-feedforward input from lateral and top-down connections (Muckli & Petro 2013 Curr. Opin. Neurobiol. 23, 195-201. (doi:10.1016/j.conb.2013.01.020)), including long-range projections from auditory areas. Early visual cortex can code for high-level auditory information, with neural patterns representing natural sound stimulation (Vetter et al. 2014 Curr. Biol. 24, 1256-1262. (doi:10.1016/j.cub.2014.04.020)). We discuss a number of questions arising from these findings. What is the adaptive function of bimodal representations in visual cortex? What type of information projects from auditory to visual cortex? What are the anatomical constraints of auditory information in V1, for example, periphery versus fovea, superficial versus deep cortical layers? Is there a putative neural mechanism we can infer from human neuroimaging data and recent theoretical accounts of cortex? We also present data showing we can read out high-level auditory information from the activation patterns of early visual cortex even when visual cortex receives simple visual stimulation, suggesting independent channels for visual and auditory signals in V1...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28032892/facing-the-dilemma-of-patient-centred-psoriasis-care-a-qualitative-study-identifying-patient-needs-in-dermatological-outpatient-clinics
#14
L R Khoury, L Skov, T Møller
BACKGROUND: Caregivers must be aware of patients' current needs by providing care responsive to the patients' values and preferences and by identifying what approach improves and encourages patients to participate in their treatment and disease management. Patients with psoriasis healthcare needs perhaps change as medical knowledge improves, new drugs emerge and the healthcare system improves its efficiency due to constant structural development. OBJECTIVES: To explore the unmet needs and health perceptions of people with psoriasis, regarding interaction with clinicians and the structure inherent to consultations in a hospital outpatient dermatological clinic...
December 29, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/28032707/surgical-technique-for-subtrochanteric-fracture-of-femur
#15
Peng-Cheng Wang, Dong Ren, Chao-Hui Song, Bing Zhou
A 56-year-old woman had fell over herself 4 h prior to her presentation to our hospital. The diagnosis was a subtrochanteric fracture of the right femur (AO-32-A3). The patient was placed in a supine position was set up on a fracture traction table after general anesthesia. The right leg was placed in abduction while the left leg was positioned so that there was flexion of the knee and hip joint. The C-arm was placed on the left side. The surgical field was sterilized and draped. Deformity and external rotation are always present for this type of fracture, so the first step was to place a joystick in the proximal fragment to correct the external rotation...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28031411/a-systematic-analysis-of-negative-growth-control-implicates-the-dream-complex-in-cancer-cell-dormancy
#16
James MacDonald, Yudith Ramos-Valdes, Piru Perampalam, Larisa Litovchick, Gabriel E DiMattia, Frederick A Dick
: Epithelial ovarian cancer (EOC) generates multicellular aggregates called spheroids that detach from the primary tumor and disseminate through ascites. Spheroids possess a number of characteristics of tumor dormancy including withdrawal from the cell cycle and resistance to chemotherapeutics. This report systematically analyzes the effects of RNAi depletion of 21 genes that are known to contribute to negative regulation of the cell cycle in 10 ovarian cancer cell lines. Interestingly, spheroid cell viability was compromised by loss of some Cyclin Dependent Kinase Inhibitors such as p57Kip2, as well as Dyrk1A, Lin52, and E2F5 in most cell lines tested...
December 28, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28024807/someday-a-scientific-dream-will-become-reality
#17
EDITORIAL
Yusuke Kambe, Tetsuji Yamaoka, Soichiro Kitamura
No abstract text is available yet for this article.
November 18, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28013229/realizing-pipe-dreams-a-detailed-picture-of-vascular-development
#18
EDITORIAL
J Peter Etchells, Simon R Turner
No abstract text is available yet for this article.
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28007991/genetic-inactivation-of-glutamate-neurons-in-the-rat-sublaterodorsal-tegmental-nucleus-recapitulates-rem-sleep-behaviour-disorder
#19
Sara Valencia Garcia, Paul-Antoine Libourel, Michael Lazarus, Daniela Grassi, Pierre-Hervé Luppi, Patrice Fort
Idiopathic REM sleep behaviour disorder is characterized by the enactment of violent dreams during paradoxical (REM) sleep in the absence of normal muscle atonia. Accumulating clinical and experimental data suggest that REM sleep behaviour disorder might be due to the neurodegeneration of glutamate neurons involved in paradoxical sleep and located within the pontine sublaterodorsal tegmental nucleus. The purpose of the present work was thus to functionally determine first, the role of glutamate sublaterodorsal tegmental nucleus neurons in paradoxical sleep and second, whether their genetic inactivation is sufficient for recapitulating REM sleep behaviour disorder in rats...
December 21, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28005464/improvement-of-darts-performance-following-lucid-dream-practice-depends-on-the-number-of-distractions-while-rehearsing-within-the-dream-a-sleep-laboratory-pilot-study
#20
Melanie Schädlich, Daniel Erlacher, Michael Schredl
In a lucid dream, the dreamer is aware of the dream state and can deliberately practice motor skills. Two field studies indicated that lucid dream practice can improve waking performance in simple motor tasks. The present pilot study investigated the effect of lucid dream practice in a controlled sleep laboratory setting, using a pre-post design with dart throwing in the evening and morning. The experimental group practiced darts in lucid dreams. Because some participants were distracted during lucid dream practice, the group was divided into lucid dreamers with few (n = 4) and many distractions (n = 5)...
December 22, 2016: Journal of Sports Sciences
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