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Diabetic nephropaty review

Halina Huk-Kolega, Beata Skibska, Paulina Kleniewska, Aleksandra Piechota, Łukasz Michalski, Anna Goraca
Oxidative stress disturbs organism's homeostasis and leads to excessive reactive oxygen species (ROS) production. Researchers are still focused on antioxidants that help to reduce oxidative stress level and are helpful in treatment of diseases were ROS overproduction is observed. Among those antioxidants is lipoic acid (LA). When applied systemically LA accumulates in tissues and is converted to dihyrolipoic acid (DHLA) by lipoamide dehydrogenase. Both LA and DHLA are biologically active. LA scavenges hydroxyl radical, subchloric acid and singlet oxygen...
September 2011: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
B Bruni, K Bruni-Bocher, A Della Valle, S Gamba
The recent literature relating to the pathogenesis of diabetic retinopathy, with or without nephropaty, is critically reviewed. Particular attention is given to the Growth Hormone (GH) hypothesis. The various procedures of hypophysectomy are discussed, including the possible ways of suppressing growth hormone production or overproduction by drugs, and expecially by medroxyprogesterone acetate (MAP). Personal results obtained with long-term administration of MAP in deposit form on alternate days in 10 patients with advanced retinopathy are described...
March 21, 1975: Minerva Medica
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