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Lung function infant preterm

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https://www.readbyqxmd.com/read/27898687/effects-of-chronologic-age-and-young-child-exposure-on-respiratory-syncytial-virus-disease-among-us-preterm-infants-born-at-32-to-35-weeks-gestation
#1
Eric A F Simões, Evan J Anderson, Xionghua Wu, Christopher S Ambrose
OBJECTIVE: To estimate the incidence of respiratory syncytial virus (RSV) disease as a function of chronologic age and exposure to young children in US preterm infants. METHODS: In the RSV Respiratory Events among Preterm Infants Outcomes and Risk Tracking (REPORT) study, preterm infants born at 32-35 weeks gestational age (wGA) were enrolled from 188 US clinics and followed September-May of 2009-2010 or 2010-2011. Infants with medically-attended acute respiratory illness had nasal/pharyngeal swabs collected for viral testing...
2016: PloS One
https://www.readbyqxmd.com/read/27861919/consequences-of-maternal-omega-3-polyunsaturated-fatty-acid-supplementation-on-respiratory-function-in-rat-pups
#2
Luana Tenorio-Lopes, Cécile Baldy, Alexandra Jochmans-Lemoine, Océane Mercier, Olivier Pothier-Piccinin, Tommy Seaborn, Vincent Joseph, Isabelle Marc, Richard Kinkead
Most preterm infants present respiratory instabilities and apneas owing to incomplete development of the neural circuits that control breathing. Because omega-3 polyunsaturated fatty acids (n-3 PUFA) benefit brain development, we hypothesized that n-3 PUFA supplementation (via maternal diet) improves respiratory function in rat pups. Pups received n-3 PUFA supplementation from an enriched diet (13 g kg(-1) of n-3 PUFA) administered to the mother from birth until experiments were performed (postnatal days 10-11)...
November 11, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27834669/a-translational-cellular-model-to-study-the-impact-of-high-frequency-oscillatory-ventilation-hfov-on-human-epithelial-cell-function
#3
Anja Karolin Mowes, Beatriz E de Jongh, Timothy Cox, Yan Zhu, Thomas H Shaffer
High frequency oscillatory ventilation (HFOV) has been proposed as gentle ventilation strategy to prevent lung injury in the preterm infant. High frequency ventilation leads to dimensional and mechanical airway deformation in animal airway models, which is consistent with translational studies demonstrating the impact of oxygen and biophysical stresses on normal airway cellular function. There is an overall paucity of clinical and cellular data on the impact of HFOV on the conducting airway. We developed an innovative method to test the impact of the clinical HFO Ventilator (Sensormedic 3100A) on human epithelial cell function...
November 10, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27832232/growth-lung-function-and-physical-activity-in-schoolchildren-who-were-very-low-birth-weight-preterm-infants
#4
Aline Dill Winck, João Paulo Heinzmann-Filho, Deise Schumann, Helen Zatti, Rita Mattiello, Marcus Herbert Jones, Renato Tetelbom Stein
Objective: To compare somatic growth, lung function, and level of physical activity in schoolchildren who had been very-low-birth-weight preterm infants (VLBWPIs) or normal-birth-weight full-term infants. Methods: We recruited two groups of schoolchildren between 8 and 11 years of age residing in the study catchment area: those who had been VLBWPIs (birth weight < 1,500 g); and those who had been normal-birth-weight full-term infants (controls, birth weight ≥ 2,500 g)...
July 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27796747/neonatal-dexamethasone-treatment-exacerbates-hypoxia-ischemia-induced-white-matter-injury
#5
Chia -Yu Yeh, Che-Ming Yeh, Ting-Hsuan Yu, Kan-Hsun Chang, Chiung-Chun Huang, Kuei-Sen Hsu
Dexamethasone, a synthetic glucocorticoid, has been widely used to prevent or ameliorate morbidity of chronic lung disease in preterm infants with respiratory distress syndrome. Despite its beneficial effect on neonatal lung function, growing concern has arisen about adverse effects of this clinical practice on fetal brain development. We demonstrated previously that neonatal dexamethasone (DEX) treatment may render the newborn brain to be more vulnerable to hypoxia/ischemia (HI)-induced gray matter injury...
October 28, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27693722/abnormal-findings-in-brainstem-auditory-evoked-response-at-36-37weeks-of-postconceptional-age-in-babies-with-neonatal-chronic-lung-disease
#6
Ze D Jiang, Cui Wang
AIM: To examine brainstem auditory function at 36-37weeks of postconceptional age in preterm infants who are diagnosed to have neonatal chronic lung disease (CLD). STUDY DESIGN: Preterm infants, born at 31 and less weeks of gestation, were studied at 36-37weeks of postconceptional age when they were diagnosed to have neonatal CLD. Brainstem auditory evoked response (BAER) was recorded and analyzed at different click rates. RESULTS: Compared with healthy controls at the same postconceptional age, the CLD infants showed a slightly increase in BAER wave V latency...
September 28, 2016: Early Human Development
https://www.readbyqxmd.com/read/27649372/the-improvement-of-respiratory-performance-after-phototherapy-induced-epc-mobilization-in-preterm-infants-with-rds
#7
Vahid Siavashi, Simin Asadian, Masoud Taheri-Asl, Homa Babaei, Samaneh Keshavarz, Mohammad Bazaei, Seyed Mahdi Nassiri
Many infants who develop bronchopulmonary dysplasia (BPD) are born with serious respiratory distress syndrome (RDS), which is associated with impaired vascular and alveolar growth. RDS is a breathing disorder that mostly affects preterm infants and occurs in infants whose lungs have not yet been fully developed. The use of surfactant in RDS treatment does not necessarily prevent BPD. Endothelial progenitor cells (EPCs) may contribute to lung angiogenesis for the prevention and treatment of BPD. The aim of this study was to evaluate the therapeutic efficacy of phototherapy for EPC release in preterm infants born with RDS...
September 20, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27634820/development-and-preclinical-testing-of-an-adaptive-algorithm-for-automated-control-of-inspired-oxygen-in-the-preterm-infant
#8
Peter A Dargaville, Omid Sadeghi Fathabadi, Gemma K Plottier, Kathleen Lim, Kevin I Wheeler, Rohan Jayakar, Timothy J Gale
OBJECTIVE: To assess the performance of a novel algorithm for automated oxygen control using a simulation of oxygenation founded on in vivo data from preterm infants. METHODS: A proportional-integral-derivative (PID) control algorithm was enhanced by (i) compensation for the non-linear SpO2-PaO2 relationship, (ii) adaptation to the severity of lung dysfunction and (iii) error attenuation within the target range. Algorithm function with and without enhancements was evaluated by iterative linking with a computerised simulation of oxygenation...
September 15, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27603531/respiratory-outcome-after-preterm-birth-a-long-and-difficult-journey
#9
Elena Priante, Laura Moschino, Veronica Mardegan, Paolo Manzoni, Sabrina Salvadori, Eugenio Baraldi
Despite notable advances in the survival and management of preterm infants in recent decades, chronic lung disease remains a common complication. Approximately one in three infants born preterm (< 32 weeks of gestation) are hospitalized with respiratory problems (mainly due to infections) in their first 2 years of life, and the risk of childhood wheezing is three times higher in this population. By comparison with infants born at term, there seems to be a higher incidence of respiratory morbidity in those born preterm, even in the absence of bronchopulmonary dysplasia (BPD) and in late-preterm babies...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27538798/efficacy-of-a-new-technique-intubate-recruit-surfactant-extubate-in-rec-sur-e-in-preterm-neonates-with-respiratory-distress-syndrome-study-protocol-for-a-randomized-controlled-trial
#10
Giovanni Vento, Roberta Pastorino, Luca Boni, Francesco Cota, Virgilio Carnielli, Filip Cools, Carlo Dani, Fabio Mosca, Jane Pillow, Graeme Polglase, Paolo Tagliabue, Anton H van Kaam, Maria Luisa Ventura, Milena Tana, Chiara Tirone, Claudia Aurilia, Alessandra Lio, Cinzia Ricci, Alessandro Gambacorta, Chiara Consigli, Danila D'Onofrio, Camilla Gizzi, Luca Massenzi, Viviana Cardilli, Alessandra Casati, Roberto Bottino, Federica Pontiggia, Elena Ciarmoli, Stefano Martinelli, Laura Ilardi, Mariarosa Colnaghi, Piero Giuseppe Matassa, Valentina Vendettuoli, Paolo Villani, Francesca Fusco, Diego Gazzolo, Alberto Ricotti, Federica Ferrero, Ilaria Stasi, Rosario Magaldi, Gianfranco Maffei, Giuseppe Presta, Roberto Perniola, Francesco Messina, Giovanna Montesano, Chiara Poggi, Lucio Giordano, Enza Roma, Carolina Grassia, Gaetano Ausanio, Fabrizio Sandri, Giovanna Mescoli, Francesco Giura, Giampaolo Garani, Agostina Solinas, Maria Lucente, Gabriella Nigro, Antonello Del Vecchio, Flavia Petrillo, Luigi Orfeo, Lidia Grappone, Lorenzo Quartulli, Antonio Scorrano, Hubert Messner, Alex Staffler, Giancarlo Gargano, Eleonora Balestri, Stefano Nobile, Caterina Cacace, Valerio Meli, Sara Dallaglio, Betta Pasqua, Loretta Mattia, Eloisa Gitto, Marcello Vitaliti, Maria Paola Re, Stefania Vedovato, Alessandra Grison, Alberto Berardi, Francesco Torcetta, Isotta Guidotti, Sandra di Fabio, Eugenia Maranella, Isabella Mondello, Stefano Visentin, Francesca Tormena
BACKGROUND: Although beneficial in clinical practice, the INtubate-SURfactant-Extubate (IN-SUR-E) method is not successful in all preterm neonates with respiratory distress syndrome, with a reported failure rate ranging from 19 to 69 %. One of the possible mechanisms responsible for the unsuccessful IN-SUR-E method, requiring subsequent re-intubation and mechanical ventilation, is the inability of the preterm lung to achieve and maintain an "optimal" functional residual capacity. The importance of lung recruitment before surfactant administration has been demonstrated in animal studies showing that recruitment leads to a more homogeneous surfactant distribution within the lungs...
August 18, 2016: Trials
https://www.readbyqxmd.com/read/27402562/effect-of-betamethasone-surfactant-and-positive-end-expiratory-pressures-on-lung-aeration-at-birth-in-preterm-rabbits
#11
Jessica R Crawshaw, Stuart B Hooper, Arjan B Te Pas, Beth A Allison, Megan J Wallace, Lauren Kerr, Robert A Lewis, Colin J Morley, Andrew F Leong, Marcus John Kitchen
Antenatal glucocorticoids, exogenous surfactant and positive end-expiratory pressure (PEEP) ventilation are commonly provided to preterm infants to enhance respiratory function after birth. It is unclear how these treatments interact to improve the transition to air-breathing at birth. We investigated the relative contribution of antenatal betamethasone, prophylactic surfactant and PEEP (3 cmH2O) on functional residual capacity (FRC) and dynamic lung compliance (CDL) in preterm (28d GA) rabbit kittens at birth...
July 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27379219/bpd-following-preterm-birth-a-model-for-chronic-lung-disease-and-a-substrate-for-ards-in-childhood
#12
REVIEW
Anita Bhandari, Christopher Carroll, Vineet Bhandari
It has been suggested that pediatric acute respiratory distress syndrome (PARDS) may be a different entity, vis-à-vis adult acute respiratory distress syndrome (ARDS), based on its epidemiology and outcomes. A more pediatric-specific definition of PARDS to include the subgroup of patients with underlying lung (and heart) disease has been proposed. Epidemiological data suggest that up to 13% of the children with ARDS have a history of prematurity and/or underlying chronic lung disease. However, the specific contribution of bronchopulmonary dysplasia (BPD), the most common chronic lung disease in infants, to the development of PARDS is not known...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27374344/functional-characterization-of-atp-binding-cassette-transporter-a3-mutations-from-infants-with-respiratory-distress-syndrome
#13
Jennifer A Wambach, Ping Yang, Daniel J Wegner, Hillary B Heins, Lyudmila N Kaliberova, Sergey A Kaliberov, David T Curiel, Frances V White, Aaron Hamvas, Brian P Hackett, F Sessions Cole
Mutations in the ATP-binding cassette transporter A3 gene (ABCA3) result in severe neonatal respiratory distress syndrome and childhood interstitial lung disease. As most ABCA3 mutations are rare or private, determination of mutation pathogenicity is often based on results from in silico prediction tools, identification in unrelated diseased individuals, statistical association studies, or expert opinion. Functional biologic studies of ABCA3 mutations are needed to confirm mutation pathogenicity and inform clinical decision making...
November 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27357257/pathogenesis-of-bronchopulmonary-dysplasia-when-inflammation-meets-organ-development
#14
REVIEW
Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci, Harald Ehrhardt
Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary function and an increased risk of abnormal somatic and psychomotor development. The contributors to this disease's entity are multifactorial with pre- and postnatal origin. Central to the pathogenesis of bronchopulmonary is the induction of a massive pulmonary inflammatory response due to mechanical ventilation and oxygen toxicity...
December 2016: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/27331352/effect-of-time-and-body-position-on-ventilation-in-premature-infants
#15
Judith Hough, Anthony Trojman, Andreas Schibler
BACKGROUND: Infants with respiratory dysfunction undergo regular position changes to improve lung function however it is not known how often a position change should occur. This study measured changes in lung function occurring over time after repositioning in preterm infants. METHODS: Changes in end-expiratory level (EEL) and ventilation distribution were measured 30 mins, 2 h, and 4 h after repositioning into either prone, quarter turn from prone, or supine using Electrical Impedance Tomography (EIT)...
October 2016: Pediatric Research
https://www.readbyqxmd.com/read/27251566/sustained-inflation-and-its-role-in-the-delivery-room-management-of-preterm-infants
#16
Gianluca Lista, Paola Azzurra La Verde, Francesca Castoldi
A noninvasive approach in the delivery room in place of intubation and mechanical ventilation can reduce rates of bronchopulmonary dysplasia and death. Nevertheless, the rate of nasal continuous positive airway pressure failure still remains high. In order to prevent lung injury and to enhance the success of continuous positive airway pressure, sustained inflation (administration by face mask or nasopharyngeal tube of a high peak pressure of 20-25 cm H2O, maintained for 10-15 s) has been recently proposed to establish an early and efficient functional residual capacity in the delivery room...
2016: Neonatology
https://www.readbyqxmd.com/read/27222921/structural-and-functional-lung-impairment-in-adult-survivors-of-bronchopulmonary-dysplasia
#17
Steven Caskey, Aisling Gough, Stephen Rowan, Scott Gillespie, Jim Clarke, Marshall Riley, Jacqui Megarry, Paul Nicholls, Chris Patterson, Henry L Halliday, Michael D Shields, Lorcan McGarvey
RATIONALE: As more preterm infants recover from severe bronchopulmonary dysplasia (BPD), it is critical to understand the clinical consequences of this condition on the lung health of adult survivors. OBJECTIVES: To assess structural and functional lung parameters in young adult BPD survivors and preterm and term control subjects. METHODS: Young adult survivors of BPD (mean age, 24 yr) underwent spirometry, lung volume assessment, transfer factor, lung clearance index, and fractional exhaled nitric oxide measurements, together with high-resolution chest computed tomography and cardiopulmonary exercise testing...
August 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27214661/lung-clearance-index-and-moment-ratios-at-different-cut-off-values-in-infant-multiple-breath-washout-measurements
#18
Barbara Egger, Kerstin Jost, Pinelopi Anagnostopoulou, Sophie Yammine, Florian Singer, Carmen Casaulta, Urs Frey, Philipp Latzin
BACKGROUND: Multiple-breath washout (MBW) is increasingly used for infant lung function testing. Current guidelines recommend calculating lung clearance index (LCI) and functional residual capacity (FRC) at 2.5% of normalized tracer gas concentration, without clear recommendation for moment ratios (MR). Whether the 2.5% cut-off has the highest discriminative power to detect ventilation inhomogeneity in infants with lung diseases is unknown. METHODS: We used sulfur-hexafluoride MBW measurements from 32 infants with cystic fibrosis, 32 preterm infants, and 32 healthy controls at postmenstrual age of 41-54 weeks...
December 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27148504/oxygen-supplementation-to-stabilize-preterm-infants-in-the-fetal-to-neonatal-transition-no-satisfactory-answer
#19
REVIEW
Isabel Torres-Cuevas, Maria Cernada, Antonio Nuñez, Javier Escobar, Julia Kuligowski, Consuelo Chafer-Pericas, Maximo Vento
Fetal life elapses in a relatively low oxygen environment. Immediately after birth with the initiation of breathing, the lung expands and oxygen availability to tissue rises by twofold, generating a physiologic oxidative stress. However, both lung anatomy and function and the antioxidant defense system do not mature until late in gestation, and therefore, very preterm infants often need respiratory support and oxygen supplementation in the delivery room to achieve postnatal stabilization. Notably, interventions in the first minutes of life can have long-lasting consequences...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27143398/structural-and-transcriptomic-response-to-antenatal-corticosteroids-in-an-erk3-null-mouse-model-of-respiratory%C3%A2-distress
#20
Braden K Pew, R Alan Harris, Elena Sbrana, Milenka Cuevas Guaman, Cynthia Shope, Rui Chen, Sylvain Meloche, Kjersti Aagaard
BACKGROUND: Neonatal respiratory distress syndrome in preterm infants is a leading cause of neonatal death. Pulmonary insufficiency-related infant mortality rates have improved with antenatal glucocorticoid treatment and neonatal surfactant replacement. However, the mechanism of glucocorticoid-promoted fetal lung maturation is not understood fully, despite decades of clinical use. We previously have shown that genetic deletion of Erk3 in mice results in growth restriction, cyanosis, and early neonatal lethality because of pulmonary immaturity and respiratory distress...
September 2016: American Journal of Obstetrics and Gynecology
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