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https://www.readbyqxmd.com/read/29161535/effect-of-dedicated-lactation-support-services-on-breastfeeding-outcomes-in-extremely-low-birth-weight-neonates
#1
Sharareh Gharib, Molly Fletcher, Richard Tucker, Betty Vohr, Beatrice E Lechner
BACKGROUND: Breastfeeding is associated with major benefits for high-risk infants born prematurely, yet this population faces significant challenges to breastfeeding. Lactation services provide successful interventions, yet the impact of lactation services on breastfeeding outcomes in preterm infants is understudied. Research aim: The provision of full-time lactation support in the neonatal intensive care unit (NICU) will improve quantitative breastfeeding measures in premature infants...
November 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29158937/connatal-urinary-ascites-in-a-female-preterm
#2
Barbara Brunner, Elisabeth Ralser, Elisabeth D'Costa, Kathrin Maurer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
Background: Connatal urinary ascites is rare in females without associated malformations and occurs following bladder rupture. Case Presentation: A female very preterm was delivered by caesarean section because of abnormal Doppler findings. The mother suffered from viral pneumonia requiring intensive care in the third trimester of pregnancy. Serial fetal ultrasound examinations showed a megacystis and ascites. Postnatally, pronounced isolated ascites was drained and its urinary nature was confirmed...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29158764/fetal-and-preterm-infant-microbiomes-a-new-perspective-of-necrotizing-enterocolitis
#3
REVIEW
Yong-Sung Choi, In Gyu Song
Necrotizing enterocolitis (NEC) is a devastating condition of hospitalized preterm infants. Numerous studies have attempted to identify the cause of NEC by examining the immunological features associated with pathogenic microorganisms. No single organism has proven responsible for the disease; however, immunological studies are now focused on the microbiome. Recent research has investigated the numerous bacterial species residing in the body and their role in diseases in preterm infants. The timing of initial microbial colonization is a subject of interest...
October 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29158370/ovarian-and-uterine-functions-in-female-survivors-of-childhood-cancers
#4
REVIEW
Ozgur Oktem, Samuel S Kim, Ugur Selek, Glenn Schatmann, Bulent Urman
Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29157051/cerebral-nirs-patterns-in-late-preterm-and-very-preterm-infants-becoming-late-preterm
#5
Alice Grometto, Benedetta Pizzo, Maria Chiara Strozzi, Francesca Gazzolo, Diego Gazzolo
BACKGROUND: Near Infrared Spectroscopy (NIRS) has been proposed as a useful, noninvasive monitoring technique providing reliable information about central nervous system (CNS) oximetry and function. Recently, brain damage has been reconsidered as a dynamic process evolving over the weeks of gestation. We therefore investigated NIRS cerebral pattern differences between healthy late preterm infants (LPTo) and very preterm infants becoming late preterm (LPT). METHODS: We conducted an observational study in 40 healthy late preterm infants, matched for gestational age at monitoring, of whom 20 where LPTo and 20 LPT...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29157044/prenatal-complications-are-associated-with-the-postnatal-airway-host-response-and-microbiota-in-intubated-preterm-infants
#6
Brandie D Wagner, Marci K Sontag, J Kirk Harris, Joshua I Miller, Lindsey Morrow, Charles E Robertson, Mark J Stephens, Brenda B Poindexter, Steven H Abman, Peter M Mourani
PURPOSE: To prospectively examine the relationship between prenatal events, postnatal airway host response and microbiota, and clinical outcomes. MATERIALS AND METHODS: Tracheal aspirates collected at 7 days of age from 71 mechanically ventilated infants (median gestational age (GA), 25 weeks [range 23-28]) were simultaneously processed for a 12-plex protein assay and bacterial identification by 16S rRNA sequencing. Phenotypes were determined by unsupervised clustering of the protein analytes...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29157039/comparison-of-cesarean-versus-vaginal-delivery-of-extremely-preterm-gestations-in-breech-presentation-retrospective-cohort-study
#7
Kirsten M Niles, Jon F R Barrett, Noor Niyar N Ladhani
OBJECTIVE: As survival increases at earlier gestational ages, the optimal mode of delivery, especially in cases of breech presentation, is of increasing importance. The objective of this study was to compare outcomes of vaginal delivery (VD) and cesarean section (CS) births for infants in breech presentation at borderline viability. STUDY DESIGN: A retrospective chart review of live breech births between 23 + 0 and 25 + 6 weeks gestation at a tertiary university center from 2003 to 2013 was conducted...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29155919/neonatal-outcomes-in-a-medicaid-population-with-opioid-dependence
#8
Susan B Brogly, Sonia Hernández-Diaz, Emily Regan, Ela Fadli, Kristen A Hahn, Martha M Werler
Confounding may account for the apparent improved infant outcomes after prenatal exposure to buprenorphine versus methadone. We used Massachusetts Medicaid Analytic eXtract (MAX) data to identify a cohort of opioid dependent mother-infant pairs (2006-2011) supplemented with confounder data from an external Boston cohort (2015-2016). Associations between prenatal buprenorphine versus methadone exposure and infant outcomes in the MAX Cohort were adjusted for measured MAX confounders, and unmeasured confounders with bias analysis using External Cohort data...
November 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29155916/a-novel-strategy-to-address-unmeasured-confounding-when-comparing-opioid-agonist-therapies-in-pregnancy
#9
Lara S Lemon
Opioid addiction in pregnancy is a growing concern that has recently received a lot of attention. When comparing recommended opioid agonist therapies, many currently published studies guiding practice may be impacted by unmeasured confounding by indication. Populations of women who receive methadone are generally different from those treated with buprenorphine. Women treated with methadone frequently have more severe and uncontrolled addiction compared with buprenorphine treated patients; however, these factors are typically unmeasured or unavailable in large observational data sets...
November 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29153908/-analysis-of-obstetric-pediatric-care-in-the-perinatal-period-are-births-before-31-weeks-gestation-in-level-2b-maternity-units-avoidable
#10
I Martin, A Roussel, M-F Olieric, M Feldmann, Y Wallerich, N Trabelsi, A Miton, C Zuily-Lamy, V Valdès, J Fresson
INTRODUCTION: Regionalization of perinatal care has been developed to improve the survival of preterm babies. The mortality rate is higher among very premature infants born outside level-3 maternity units. The objective of this study was to evaluate the preventability of these very premature births occurring outside recommendations within level-2B maternity units. The secondary objective was to describe the care of premature infants between 23 and 24 weeks. METHODS: This is a single-center retrospective qualitative study of the care delivery pathways...
November 16, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29153738/pregnancy-outcomes-following-cardiac-transplantation
#11
Rohan D'Souza, Elisabeth Soete, Candice K Silversides, Nusrat Zaffar, Tim Van Mieghem, Johan Van Cleemput, Catriona Bhagra, Mathew Sermer, Heather Ross
OBJECTIVE: This study sought to report pregnancy outcomes in women following cardiac transplantation. METHODS: This was a descriptive retrospective cohort study of women with pregnancies following cardiac transplantation managed at two large tertiary centres in Canada and Belgium between 2001 and 2017. RESULTS: Sixteen women had 17 singleton pregnancies following cardiac transplantation. The mean maternal age was 28 ± 5.8, and the transplant-to-pregnancy interval was 7...
November 15, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29153057/sex-dependent-influence-of-developmental-toxicant-exposure-on-group-b-streptococcus-mediated-preterm-birth-in-a-murine-model
#12
Tianbing Ding, Lauren A Lambert, David M Aronoff, Kevin G Osteen, Kaylon L Bruner-Tran
Infectious agents are a significant risk factor for preterm birth (PTB); however, the simple presence of bacteria is not sufficient to induce PTB in most women. Human and animal data suggest that environmental toxicant exposures may act in concert with other risk factors to promote PTB. Supporting this "second hit" hypothesis, we previously demonstrated exposure of fetal mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to an increased risk of spontaneous and infection-mediated PTB in adult animals...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29152912/physiological-and-anatomical-dead-space-in-mechanically-ventilated-newborn-infants
#13
Theodore Dassios, Paul Dixon, Ann Hickey, Sotirios Fouzas, Anne Greenough
OBJECTIVES: To compare the anatomical (VD-Ana ) and alveolar dead space (VD-Alv ) in term and prematurely born infants and identify the clinical determinants of those indices. WORKING HYPOTHESIS: VD-Ana and VD-Alv will be higher in prematurely born compared to term born infants. STUDY DESIGN: Retrospective analysis of data collected at King's College Hospital NHS Foundation Trust, London, UK. PATIENT SELECTION: Fifty-six infants (11 term, 45 preterm) were studied at a median age of 8 (IQR 2-33) days...
November 20, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29152325/changes-of-intestinal-microbiota-composition-and-diversity-in-very-low-birth-weight-infants-related-to-strategies-of-nec-prophylaxis-protocol-for-an-observational-multicentre-pilot-study
#14
Stefan Kurath-Koller, Christine Moissl-Eichinger, Gregor Gorkiewicz, Raimund Kraschl, Claudia Kanduth, Barbara Hopfer, Berndt Urlesberger, Bernhard Resch
Background: At the Division of Neonatology, Department of Paediatrics, Medical University Graz, a unique regimen of necrotizing enterocolitis (NEC) prophylaxis in preterm infants showing a < 1500 g birth weight (i.e. very low birth weight, VLBW) is used. The regimen includes oral antibiotic and antifungal therapy and probiotic preparations as well as a standardised feeding regimen. The incidence of NEC in preterm infants treated by this regimen has been shown to be lower, reflecting 0...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29150862/randomised-crossover-trial-showed-that-using-breast-milk-or-sucrose-provided-the-same-analgesic-effect-in-preterm-infants-of-at-least-28-weeks
#15
L Collados-Gómez, P Ferrera-Camacho, E Fernandez-Serrano, V Camacho-Vicente, C Flores-Herrero, A M García-Pozo, R Jiménez-García
AIM: Repeated, on-going exposure to pain influences the growth, cognitive and motor functions, behaviour, personality and neurodevelopment of preterm infants. We compared the analgesic effects of expressed breast milk and 24% oral sucrose on preterm neonates during venipuncture. METHODS: This multicentre randomised, non-inferiority, cross-over trial focused on five neonatal university units in Madrid, Spain, from October 2013 to October 2014. It comprised 66 preterm infants born at less than 37 weeks and randomly split into two groups...
November 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29150469/impact-of-preterm-birth-on-parental-separation-a-french-population-based-longitudinal-study
#16
Simon Nusinovici, Bertrand Olliac, Cyril Flamant, Jean-Baptiste Müller, Marion Olivier, Valérie Rouger, Géraldine Gascoin, Hélène Basset, Charlotte Bouvard, Jean-Christophe Rozé, Matthieu Hanf
OBJECTIVE: The objective of this study was to investigate both the effects of low gestational age and infant's neurodevelopmental outcome at 2 years of age on the risk of parental separation within 7 years of giving birth. DESIGN: Prospective. SETTING: 24 maternity clinics in the Pays-de-la-Loire region. PARTICIPANTS: This study included 5732 infants delivered at <35 weeks of gestation born between 2005 and 2013 who were enrolled in the population-based Loire Infant Follow-up Team cohort and who had a neurodevelopmental evaluation at 2 years...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29150458/diagnostic-accuracy-of-neonatal-assessment-for-gestational-age-determination-a-systematic-review
#17
REVIEW
Anne Cc Lee, Pratik Panchal, Lian Folger, Hilary Whelan, Rachel Whelan, Bernard Rosner, Hannah Blencowe, Joy E Lawn
CONTEXT: An estimated 15 million neonates are born preterm annually. However, in low- and middle-income countries, the dating of pregnancy is frequently unreliable or unknown. OBJECTIVE: To conduct a systematic literature review and meta-analysis to determine the diagnostic accuracy of neonatal assessments to estimate gestational age (GA). DATA SOURCES: PubMed, Embase, Cochrane, Web of Science, POPLINE, and World Health Organization library databases...
November 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/29150167/reproductive-factors-in-relation-to-heart-failure-in-women-a-systematic-review
#18
REVIEW
Renee Bolijn, N Charlotte Onland-Moret, Folkert W Asselbergs, Yvonne T van der Schouw
BACKGROUND: The biological mechanisms underlying the sex-related differences in risk of heart failure are still not well understood. The aim of this review was to provide an overview of the current evidence on the association between reproductive factors and risk of heart failure in women. METHODS: A systematic review of the literature was conducted. PubMed and Embase databases were searched for publications on the following reproductive factors as potential risk factors for heart failure in women: age at menarche, duration and frequency of the menstrual cycle, reproductive lifespan, use of contraception, polycystic ovarian syndrome (PCOS), pregnancy characteristics (e...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29150046/oxidative-stress-and-dna-damage-in-the-cord-blood-of-preterm-infants
#19
Mahmood Norishadkam, Soudeh Andishmand, Javad Zavar Reza, Mohammad Javad Zare Sakhvidi, Vida Rezae Hachesoo
Preterm birth infants are more susceptible to oxidative stress and aftermaths unwanted outcomes such as DNA damage due to hyperoxic stress. In this study, we compared the DNA strand breaks as one of the results of DNA oxidation in white blood cells, malondialdehyde (oxidative stress marker), catalase and superoxide dismutase activity, and total antioxidant capacity (markers of antioxidant defense) in a cord blood plasma of a group of preterm (n=25) and full term births (n=25). The primary DNA damage and plasma oxidative stress markers were significantly higher in a preterm group (p<0...
December 2017: Mutation Research
https://www.readbyqxmd.com/read/29149869/characterisation-of-sucking-dynamics-of-breastfeeding-preterm-infants-a-cross-sectional-study
#20
Donna T Geddes, Kok Chooi, Kathryn Nancarrow, Anna R Hepworth, Hazel Gardner, Karen Simmer
BACKGROUND: Full breastfeeding is the ultimate aim for preterm infants to ensure they receive the full benefits of human milk however, preterm infants face a number of challenges associated with their immaturity and associated morbidities. In order to facilitate oral feeding, it is essential to have a sound knowledge of the sucking dynamics of the breastfed infant. The aim of this study was to measure and describe the sucking dynamics of the preterm breastfeeding infant. METHODS: A prospective cross sectional observational study was carried out at King Edward Memorial Hospital, Perth...
November 17, 2017: BMC Pregnancy and Childbirth
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