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JOURNAL ARTICLE
Wenyu Jiao, Mercedes Martinez, Constanza Bay Muntnich, Julien Zuber, Christopher Parks, Aleksandar Obradovic, Guangyao Tian, Zicheng Wang, Katherine D Long, Elizabeth Waffarn, Kristjana Frangaj, Rebecca Jones, Alaka Gorur, Brittany Shonts, Kortney Rogers, Guoyue Lv, Monica Velasco, Shilpa Ravella, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Jianing Fu, Megan Sykes
BACKGROUND: Understanding formation of the human tissue resident memory T cell (TRM) repertoire requires longitudinal access to human non-lymphoid tissues. METHODS: By applying flow cytometry and next generation sequencing to serial blood, lymphoid tissue, and gut samples from 16 intestinal transplantation (ITx) patients, we assessed the origin, distribution, and specificity of human TRMs at phenotypic and clonal levels. FINDINGS: Donor age ≥1 year and blood T cell macrochimerism (peak level ≥4%) were associated with delayed establishment of stable recipient TRM repertoires in the transplanted ileum...
February 28, 2024: EBioMedicine
#22
JOURNAL ARTICLE
Dace Abele, Markus Gäbel, Mihai Oltean, Jonas Varkey, Johan Mölne, Nils Ekwall, Helena Borg, Hanna Jacobsson, Jan Holgersson, Gustaf Herlenius
Humoral immunity emerges as a risk factor for graft failure after visceral transplantation (VTx) and development of donor-specific anti-HLA antibodies (DSAs) has been linked with poor outcomes. In most cases, a simultaneous liver transplant can be safely performed in sensitized patients with DSA and appears protective against lymphocytotoxic antibodies. We investigated the incidence of acute (AR) and chronic rejection (CR) in 32 VTx without any B cell-depleting pre-treatment (6 isolated intestinal transplants (IT) and 26 liver-containing, multivisceral transplants (MVT) and assessed the presence of donor-specific antibodies (DSA) pre- and post-transplantation...
February 27, 2024: Human Immunology
#23
JOURNAL ARTICLE
Chethan Ashokkumar, Mylarappa Ningappa, Vikram Raghu, George Mazariegos, Brandon W Higgs, Paul Morgan, Lisa Remaley, Tamara Fazzolare Martin, Pamela Holzer, Kevin Trostle, Qingyong Xu, Adriana Zeevi, James Squires, Kyle Soltys, Simon Horslen, Ajai Khanna, Armando Ganoza, Rakesh Sindhi
BACKGROUND: Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index (API) in an exploratory cohort of liver and intestine transplant (LT and IT) recipients. METHODS: To test clinical performance, we measured the API using the previously described 6-h assay in 84 LT and 54 IT recipients with median age 3...
March 2024: Transplantation Direct
#24
JOURNAL ARTICLE
Chandrashekhar A Kubal, Plamen Mihaylov, Riley Snook, Daiki Soma, Omer Saeed, Zachary Rokop, Marco Lacerda, Brett H Graham, Richard S Mangus
BACKGROUND Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is an autosomal recessive disease caused by thymidine phosphorylase deficiency leading to progressive gastrointestinal dysmotility, cachexia, ptosis, ophthalmoparesis, peripheral neuropathy and leukoencephalopathy. Although liver transplantation corrects thymidine phosphorylase deficiency, intestinal deficiency of the enzyme persists. Retrospective chart review was carried out to obtain clinical, biochemical, and pathological details...
February 27, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
#25
JOURNAL ARTICLE
Allison J Kwong, Erin Schnellinger, Julia Foutz, Matt Cafarella, Shunji Nagai, Scott W Biggins, James Pomposelli, James Trotter
Candidates for multivisceral transplant (MVT) have experienced decreased access to transplant in recent years. Using Organ Procurement and Transplantation Network data, transplant and waiting list outcomes for MVT (ie, liver-intestine, liver-intestine-pancreas, and liver-intestine-kidney-pancreas) candidates listed between February 4, 2018, and February 3, 2022, were analyzed, including model for end-stage liver disease/pediatric end-stage liver disease and exception scores by era (before and after acuity circle [AC] implementation on February 4, 2020) and age group (pediatric and adult)...
February 24, 2024: American Journal of Transplantation
#26
JOURNAL ARTICLE
Masato Shimada, Yoshihisa Koyama, Yuki Kobayashi, Yasunari Matsumoto, Hikaru Kobayashi, Shoichi Shimada
The progression of small bowel ischemia-reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Therefore, developing therapeutic agents that can prevent IR injury at early stages and suppress its progression is imperative. As IR injury may be closely related to oxidative stress, antioxidants can be effective therapeutic agents. Our silicon (Si)-based agent, an antioxidant, generated a large amount of hydrogen in the intestinal tract for a prolonged period after oral administration...
February 20, 2024: Scientific Reports
#27
JOURNAL ARTICLE
Edo Dongelmans, Nicole Erler, Rene Adam, Silvio Nadalin, Vincent Karam, Sezai Yilmaz, Claire Kelly, Jacques Pirenne, Koray Acarli, Michael Allison, Abdul Hakeem, Dhakshinamoorthy Vijayanand, Dzmitry Fedaruk, Oleg Rummo, Murat Kilic, Arno Nordin, Lutz Fischer, Alessandro Parente, Darius Mirza, William Bennet, Yaman Tokat, Francois Faitot, Barbara B Antonelli, Gabriela Berlakovich, David Patch, Frederik Berrevoet, Marija Ribnikar, Theophile Gerster, Eric Savier, Salvatore Gruttadauria, Bo-Göran Ericzon, Andrés Valdivieso, Valentin Cuervas-Mons, Baltasar Perez Saborido, Roland S Croner, Luciano De Carlis, Giulia Magini, Roberta Rossi, Irinel Popescu, Laze Razvan, Stefan Schneeberger, Hans Blokzijl, Laura Llado, Miguel Angel Gomez Bravo, Christophe Duvoux, Vladimír Mezjlík, Gabriel C Oniscu, Kelsey Pearson, Murat Dayangac, Valerio Lucidi, Olivier Detry, Fernando Rotellar, Caroline den Hoed, Wojciech G Polak, Sarwa Darwish Murad
BACKGROUND AND AIMS: Management of Budd-Chiari Syndrome (BCS) has improved over the last decades. The main aim was to evaluate the contemporary post-liver transplant (LT) outcomes in Europe. APPROACH AND RESULTS: Data from all transplanted patients from 1976-2020 was obtained from the European Liver Transplantation Registry (ELTR). Patients<16yrs, with secondary BCS or hepatocellular carcinoma were excluded. Patient- (PS) and graft survival (GS) before and after 2000 were compared...
February 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#28
JOURNAL ARTICLE
Chen-Huan Yu, Yun Chen, Chien-Chen Tsai, Tzong-Hsi Lee, Ya-Hui Tsai, Chen-Shuan Chung
Crohn disease (CD) is one of the most common causes of short bowel syndrome and intestinal failure. Intestinal transplantation (IT) is sometimes needed for patients with CD who develop intestinal failure after multiple intestinal resections resulting from CD-related complications, such as uncontrollable bleeding and penetrating diseases. However, there have been few case reports concerning the endoscopic surveillance of patients with CD after IT. In this article, we present 2 patients with CD who underwent IT because of short bowel syndrome with intestinal failure...
February 8, 2024: Transplantation Proceedings
#29
JOURNAL ARTICLE
Amy L Lightner, Masato Fujiki, Mohamed Elshawy, Neda Dadgar, Anita Barnoski, Mohammed Osman, Clifton Fulmer, Anil Vaidya
Solid abdominal organ transplantation is fraught with variable rates of rejection and graft versus host disease. We sought to determine the safety and efficacy of an advanced extracellular vesicle (EV) investigational product (IP) derived from mesenchymal stem cells (MSC) in the transplant patient population. Seven separate eINDs were filed with the FDA for the emergency treatment of rejection of an isolated intestinal graft (n=2), liver allograft graft (n=2), modified multivisceral graft (n=3), and GVHD in isolated intestinal transplant patients (n=2)...
February 1, 2024: Stem Cells and Development
#30
JOURNAL ARTICLE
Dagny von Ahrens, Andrew D Santeusanio, Alan D Weinberg, Jang Moon, Kishore R Iyer
INTRODUCTION: Kidney dysfunction is a known complication of intestinal transplantation; however, the rate of development and risk factors for chronic kidney disease (CKD) remain poorly defined. METHODS: This was a single-center retrospective review of isolated adult intestinal allograft recipients from 2011 to 2019. Patients who died or experienced graft loss within 1-year or had a prior transplant were excluded. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation at 0-, 6- and 12-months post-transplant, and multivariable linear regression was performed to identify variables associated with adjusted eGFR at 1-year...
January 2024: Clinical Transplantation
#31
JOURNAL ARTICLE
Zoi Bouloubasi, Dimitrios Karayiannis, Anna Papadopoulou, Nikolaos Dimitrokallis, Aggeliki Tsanasa, Eleni Karveli, Vasilios Vougas
BACKGROUND: Despite being a long-term therapy for patients with short bowel syndrome (SBS), subcutaneous injections of teduglutide promote the regeneration of the gastrointestinal tract. Such cases are particularly concerning for patients with residual small bowel. METHODS: In this report, we present a case of an SBS patient with only 5 cm of remaining small bowel and a high-output duodenal stoma, who was treated with teduglutide. RESULTS: The initiation of teduglutide injections in our patient resulted in a reduction of stoma output, improvement in the patient's nutritional status, regulation of fluid balance, and stabilization of their clinical condition...
January 24, 2024: European Journal of Clinical Nutrition
#32
JOURNAL ARTICLE
Emilio Canovai, Andrew Butler, Susan Clark, Andrew Latchford, Ashish Sinha, Lisa Sharkey, Charlotte Rutter, Neil Russell, Sara Upponi, Irum Amin
BACKGROUND: Desmoid tumors are fibroblastic lesions which often have an unpredictable and variable clinical course. In the context of familial adenomatous polyposis (FAP), these frequently occur intra-abdominally, especially in the small-bowel mesentery resulting in sepsis, fistulation, and invasion of the abdominal wall and retroperitoneum. In selected cases where other modalities have failed, the most radical option is to perform a total enterectomy and intestinal transplantation (ITx)...
February 2024: Transplantation Direct
#33
REVIEW
Alejandra Utrilla Fornals, Cristian Costas-Batlle, Sophie Medlin, Elisa Menjón-Lajusticia, Julia Cisneros-González, Patricia Saura-Carmona, Miguel A Montoro-Huguet
Many patients undergo small bowel and colon surgery for reasons related to malignancy, inflammatory bowel disease (IBD), mesenteric ischemia, and other benign conditions, including post-operative adhesions, hernias, trauma, volvulus, or diverticula. Some patients arrive in the operating theatre severely malnourished due to an underlying disease, while others develop complications (e.g., anastomotic leaks, abscesses, or strictures) that induce a systemic inflammatory response that can increase their energy and protein requirements...
January 12, 2024: Nutrients
#34
JOURNAL ARTICLE
Johns Shaji Mathew, Alexandra Shingina, Mohammad Qasim Khan, Elizabeth Wilson, Nicholas Syn, Ashwin Rammohan, Felipe Alconchel, Abdul Rahman Hakeem, Sadhana Shankar, Dhupal Patel, Onur Keskin, Jiang Liu, David Nasralla, Alessandra Mazzola, Madhukar S Patel, Tomohiro Tanaka, David Victor, Uzung Yoon, Young-In Yoon, Carmen Vinaixa, Varvara Kirchner, Eleonora De Martin, R Mark Ghobrial, Ryan Chadha
The 2023 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestine Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE) held in Rotterdam, the Netherlands, marked a significant recovery milestone for the liver transplant community after COVID-19. With 1159 participants and a surge in abstract submissions, the event focused on "Liver Disorders and Transplantation: Innovations and Evolving Indications." This conference report provides a comprehensive overview of the key themes discussed during the event, encompassing Hepatology, Anesthesia and Critical Care, Acute Liver Failure, Infectious Disease, Immunosuppression, Pediatric Liver Transplantation, Living Donor Liver Transplantation, Transplant Oncology, Surgical Approaches, and Machine Perfusion...
January 22, 2024: Liver Transplantation
#35
JOURNAL ARTICLE
Colin Hartgerink, Shunji Nagai, Yakir Muszkat, Nemie Beltran, Syed-Mohammed Jafri
BACKGROUND: Ileostomies are typically created at the time of intestinal and multivisceral transplantation to assist in graft monitoring with endoscopy and biopsies. Often, these ostomies are reversed with a takedown procedure once there is stable graft function, but data are limited on associated complications of the takedown procedure for patients with intestinal transplants. METHODS: To assess complications associated with takedowns in this patient population, we performed a retrospective analysis of patients who had an intestinal transplant with elective ostomy takedown after transplant...
January 2, 2024: Transplantation Proceedings
#36
REVIEW
Teera Kijmassuwan, Fariha Balouch
Congenital diarrhea and enteropathies (CODEs) constitute a group of rare genetic disorders characterized by severe diarrhea and malabsorption in the neonatal period or early infancy. Timely diagnosis and treatment is essential to prevent life-threatening complications, including dehydration, electrolyte imbalance, and malnutrition. This review offers a simplified approach to the diagnosis of CODEs, with a specific focus on microvillus inclusion disease (MVID), congenital tufting enteropathy (CTE), congenital chloride diarrhea (CLD), and congenital sodium diarrhea (CSD)...
December 18, 2023: Indian Journal of Pediatrics
#37
JOURNAL ARTICLE
Jianing Fu, Zicheng Wang, Mercedes Martinez, Aleksandar Obradovic, Wenyu Jiao, Kristjana Frangaj, Rebecca Jones, Xinzheng V Guo, Ya Zhang, Wan-I Kuo, Huaibin M Ko, Alina Iuga, Constanza Bay Muntnich, Adriana Prada Rey, Kortney Rogers, Julien Zuber, Wenji Ma, Michelle Miron, Donna L Farber, Joshua Weiner, Tomoaki Kato, Yufeng Shen, Megan Sykes
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of graft-repopulating recipient T cells in the intestinal mucosa at the single-cell level after human intestinal transplantation. Host-versus-graft (HvG)-reactive T cells were mainly distributed to TRM, effector T (Teff)/TRM, and T follicular helper compartments. RNA velocity analysis demonstrated a trajectory from TRM to Teff/TRM clusters in association with rejection...
January 1, 2024: Journal of Experimental Medicine
#38
JOURNAL ARTICLE
Guosheng Wu, Long Zhao, Weiqin Jiang, Chaoxu Liu, Xile Zhou, Wentong Zhang, Jinhai Wang, Tingbo Liang
OBJECTIVE: To examine the outcomes of intestinal autotransplantation (IATx) in patients with locally advanced or recurrent colon cancer (LACC or LRCC) invading the superior mesenteric artery (SMA). BACKGROUND: SMA Involvement in LACC or LRCC is deemed unresectable and is associated with a poor prognosis. Combined extended resections of multiple organs together with SMA, followed by IATx may offer favorable clinical outcomes. However, data on its safety and efficacy are scarce...
December 13, 2023: Annals of Surgery
#39
JOURNAL ARTICLE
Julie S Hong, Abrar Shamim, Hussein Atta, Eric B Nonnecke, Sarah Merl, Satyajit Patwardhan, Elin Manell, Esad Gunes, Philip Jordache, Bryan Chen, Wuyuan Lu, Bo Shen, Beatrice Dionigi, Ravi P Kiran, Megan Sykes, Emmanuel Zorn, Charles L Bevins, Joshua Weiner
Intestinal transplantation is the definitive treatment for intestinal failure. However, tissue rejection and graft-versus-host disease are relatively common complications, necessitating aggressive immunosuppression that can itself pose further complications. Tracking intraluminal markers in ileal effluent from standard ileostomies may present a noninvasive and sensitive way to detect developing pathology within the intestinal graft. This would be an improvement compared to current assessments, which are limited by poor sensitivity and specificity, contributing to under or over-immunosuppression, respectively, and by the need for invasive biopsies...
December 9, 2023: Journal of Immunological Methods
#40
JOURNAL ARTICLE
Mariano Cesare Giglio, Pasquale Dolce, Sezai Yilmaz, Yaman Tokat, Koray Acarli, Murat Kilic, Murat Zeytunlu, Tarkan Unek, Vincent Karam, René Adam, Wojciech Grzegorz Polak, Constantino Fondevila, Silvio Nadalin, Roberto Ivan Troisi
Graft survival is a critical endpoint in adult-to-adult living donor liver transplantation (ALDLT), where graft procurement endangers the lives of healthy individuals. Therefore, ALDLT must be responsibly performed in the perspective of a positive harm-to-benefit ratio. This study aimed to develop a risk prediction model for early (3-months) graft failure (EGF) following ALDLT. Donor and recipient factors associated with EGF in ALDLT were studied using data from the European Liver Transplant Registry. An artificial neural network classification algorithm (ANN) was trained on a set of 2073 ALDLTs, validated using cross-validation, tested on an independent random-split sample (n=518), and externally validated on United Network for Organ Sharing Standard Transplant Analysis and Research data...
December 12, 2023: Liver Transplantation
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