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JOURNAL ARTICLE
Murilo Augusto Ferreira, Lucas Ferreira Fagundes Ouverney, Mariana Curceli Figueiredo, André Ibrahim David
BACKGROUND: Intestinal transplantation (IT) and multivisceral transplantation (MVT) are curative therapies for patients with intestinal failure and severe complications associated with total parenteral nutrition. High levels of immunosuppression are required to prevent acute cellular rejection (ACR) from the bowel. Studies regarding pre-treatment, induction, and post-transplant therapy have improved graft acceptance, reducing immunosuppression doses and infectious complications. However, the low rate of IT and MVT and the small number of specialized centers have resulted in a limited number of evidence-based immunosuppression protocols...
April 21, 2023: Transplantation Proceedings
#22
REVIEW
Shunji Nagai
PURPOSE OF REVIEW: Neuroendocrine tumor (NET) liver metastatic lesions are often multiple and found to be unresectable. Rationale of multivisceral transplantation (MVT: liver-pancreas-intestine transplantation) include radical and complete resection of primary, visible and invisible metastatic tumors by removing all abdominal organs and the lymphatic system. This review aims to describe the concept of MVT for NET and neuroendocrine liver metastasis (NELM), patient selection, timing of MVT, and posttransplant outcomes and management...
June 1, 2023: Current Opinion in Organ Transplantation
#23
JOURNAL ARTICLE
Emily E Currier, Yervant Ichkanian, Mohamad Dabaja, Maria Cristina Segovia, Yuval Patel, Shunji Nagai, Debra L Sudan, Syed-Mohammed Jafri
Intestinal transplant and multivisceral transplant were originally in pediatric populations and are relatively new procedures in adults. Despite increasing success rates in the immediate post-transplant period, infectious complications and acute and chronic rejection remain significant causes of morbidity and mortality. Previous research has shown cytomegalovirus (CMV) is the main cause of infection in this population. Due to the limited patient population, incidence of CMV viremia ranges widely and there is lack of universal protocol for treatment...
February 13, 2023: Transplantation Proceedings
#24
REVIEW
Emil Bluhme, Ewa Henckel, Carl Jorns
Organ transplantation is limited by access to suitable organs. Infant recipient waitlist mortality is increased due to the scarcity of size-matched organs. Neonatal organ donors have been proposed as an underutilized source of donor organs. However, the literature on the actual prevalence and outcome of neonatal organ donation and transplantation is fragmented and not well analyzed. This literature review aims to summarize the available literature on the potential of neonatal organ donation and to analyze published cases of neonatal organ transplantation...
February 15, 2023: Pediatric Transplantation
#25
REVIEW
Aude Van Oosterwyck, Nathalie Lauwers, Nelle Pauwels, Tim Vanuytsel
PURPOSE OF REVIEW: Intestinal transplantation (ITx), whether isolated or combined with other organs, is now a valid treatment option in some patients with chronic intestinal failure or extensive venous mesenteric thrombosis. The aim in these patients is not only to restore nutritional autonomy, but also to minimize the risk of complications, both short and long term. Despite parenteral nutrition playing a central part in the management of intestinal failure patients, there are little data about the perioperative and postoperative nutritional management of ITx patients, due to small patient populations per centre...
March 1, 2023: Current Opinion in Clinical Nutrition and Metabolic Care
#26
Ane M Andres, Jose Luis Encinas, Alba Sánchez-Galán, Javier Serradilla Rodríguez, Karla Estefania, Rocio Gonzalez Sacristan, Alida Alcolea, Pilar Serrano, Belén Estébanez, Iñigo Velasco Leon, Paula Burgos, Alvaro Gonzalez Rocafort, Bunty Ramchandani, Belén Calderón, Cristina Verdú, Esperanza Jimenez, Paloma Talayero, Pablo Stringa, Itziar de la Peña Navarro, Esther Ramos, Francisco Hernandez Oliveros
The current shortage of pediatric multivisceral donors accounts for the long time and mortality on the waiting list of pediatric patients. The use of donors after cardiac death, especially after the outbreak of normothermic regional perfusion, has increased in recent years for all solid organs except the intestine, mainly because of its higher susceptibility to ischemia-reperfusion injury. We present the first literature case of multivisceral donors after cardiac death transplantation in a 13-month-old recipient from a 2...
January 5, 2023: American Journal of Transplantation
#27
MULTICENTER STUDY
Yiliam Fundora, Amelia J Hessheimer, Luca Del Prete, Lorenzo Maroni, Jacopo Lanari, Oriana Barrios, Mathias Clarysse, Mikel Gastaca, Manuel Barrera Gómez, Agnès Bonadona, Julius Janek, Andrea Boscà, Jose María Álamo Martínez, Gabriel Zozaya, Dolores López Garnica, Paolo Magistri, Francisco León, Giulia Magini, Damiano Patrono, Jiří Ničovský, Abdul Rahman Hakeem, Silvio Nadalin, Lucas McCormack, Pilar Palacios, Krzysztof Zieniewicz, Gerardo Blanco, Javier Nuño, Baltasar Pérez Saborido, Juan Echeverri, J Steve Bynon, Paulo N Martins, Víctor López López, Murat Dayangac, J Peter A Lodge, Renato Romagnoli, Christian Toso, Julio Santoyo, Fabrizio Di Benedetto, Concepción Gómez-Gavara, Fernando Rotellar, Miguel Ángel Gómez-Bravo, Rafael López Andújar, Edouard Girard, Andrés Valdivieso, Jacques Pirenne, Laura Lladó, Giacomo Germani, Matteo Cescon, Koji Hashimoto, Cristiano Quintini, Umberto Cillo, Wojciech G Polak, Constantino Fondevila
BACKGROUND & AIMS: Complex portal vein thrombosis (PVT) is a challenge in liver transplantation (LT). Extra-anatomical approaches to portal revascularization, including renoportal (RPA), left gastric vein (LGA), pericholedochal vein (PCA), and cavoportal (CPA) anastomoses, have been described in case reports and series. The RP4LT Collaborative was created to record cases of alternative portal revascularization performed for complex PVT. METHODS: An international, observational web registry was launched in 2020...
April 2023: Journal of Hepatology
#28
JOURNAL ARTICLE
Yeh-Chung Chang, Rebecca R Young, Alisha M Mavis, Eileen T Chambers, Sonya Kirmani, Matthew S Kelly, Ibukunoluwa C Kalu, Michael J Smith, Debra J Lugo
BACKGROUND: Pediatric solid organ transplant (SOT) recipients commonly have Epstein-Barr virus (EBV) DNAemia and are at risk of developing post-transplant lymphoproliferative disorder (PTLD). EBV DNAemia has not been analyzed on a continuous scale in this population. METHODS: All children ≤ 18 years of age who underwent SOT at a single center between January 1, 2007 and July 31, 2018 were included in this retrospective study. Transplant episodes in which PTLD occurred were compared to transplant episodes without PTLD...
2022: PloS One
#29
JOURNAL ARTICLE
Laura T Reed, Scott R Echternacht, Kumaran Shanmugarajah, Roberto Hernandez, Howard N Langstein, Jonathan I Leckenby
BACKGROUND: Abdominal wall allotransplantation following intestinal and multivisceral transplant procedures has proven to be successful in achieving adequate closure in patients in whom other techniques have proven inadequate. Thus far, the focus of these abdominal wall allotransplants has been on graft and overall patient survival following surgery and the implementation of immunosuppression. The purpose of this study was to review the outcomes of abdominal wall allotransplantation reported in the literature...
November 1, 2022: Plastic and Reconstructive Surgery
#30
JOURNAL ARTICLE
J Livingstone, Y Raveh, F Souki, V Shatz, R Shah, T Ibrahim, M Shuman, T Beduschi, R Vianna, R Alvarez, R Nicolau-Raducu
Portopulmonary hypertension, a type of pulmonary arterial hypertension in the setting of cirrhotic or noncirrhotic portal hypertension, is associated with elevated morbidity and mortality during and after transplantation. Uncontrolled portopulmonary hypertension may prevent or delay listing for transplant candidates, and the prognosis without treatment and ultimately transplant is extremely poor. We present a 29-year-old White woman, who had a post-liver transplant at infancy due to biliary atresia. Later on, she developed extensive portal vein thrombosis and portopulmonary hypertension and underwent a multivisceral transplant (liver, stomach, pancreaticoduodenal complex, and small and large intestine)...
July 29, 2022: Transplantation Proceedings
#31
Lucía González González, Iago Justo Alonso, Sandra García Caspueñas, Manuel Hernández Larrea, Carmelo Loinaz Segurola
No abstract text is available yet for this article.
July 29, 2022: Cirugia española
#32
JOURNAL ARTICLE
Hamed Nikoupour, Mohammad Bagher Khosravi, Pooya Vatankhah, Mojtaba Shafiekhani, Alireza Shamsaeefar, Peyman Arasteh, Mohammad Hossein Anbardar, Mohammad Hossein Eghbal, MohammadAli Sahmeddini, Fatemeh Khalili, Mohammad Firoozifar, Samaneh Ghazanfar Tehran, Saman Nikeghbalian
BACKGROUND: Many regions of the world, especially middle- and low-income countries, lack facilities for home parenteral nutrition and thus cannot follow existing guidelines for intestinal transplantation. Herein, we report our experiences with treatment protocols, intra- operative management, and early postoperative outcomes among patients undergoing either isolated intestinal transplantation or multivisceral transplantation in our center. METHODS: During a 1-year period from March 2019 to March 2020, a total of 9 intestinal transplantations including 6 isolated intes- tinal transplantations and 3 multivisceral transplantations were performed in our center...
July 5, 2022: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
#33
JOURNAL ARTICLE
Marten Schulz, Mira Choi, Friederike Bachmann, Nadine Koch, Theresa Maria Holtmann, Raphael Mohr, Frank Tacke, Alexander Wree
Background: Hepatitis E virus (HEV) infection especially in immunocompromised individuals can lead to chronic hepatitis. Aggressive courses of chronic hepatitis E leading to liver cirrhosis in a short period of time have been described, but evidence on the degree of liver involvement in chronic hepatitis E is rare. We therefore aimed to quantify liver fibrosis in patients with chronic active hepatitis E compared to patients with sustained virological response after ribavirin (RBV) treatment using 2D-shear wave elastography (2D-SWE) to measure liver stiffness...
July 2022: Quantitative Imaging in Medicine and Surgery
#34
REVIEW
Bo Wei, Zhiyin Huang, Chengwei Tang
Cavernous transformation of the portal vein (CTPV) is a sequela of extrahepatic and/or intrahepatic portal vein obstruction caused by a combination of local and risk factors. It was ever taken as a relatively rare disease due to its scant literature, which was mainly based on clinical series and case reports. CTPV often manifests as gastroesophageal variceal bleeding, splenomegaly, and portal biliopathy after the long-term insidious presentation. It is unable for CTPV to be recanalized with anticoagulation because it is a complete obstruction of the mesentericoportal axis...
2022: Frontiers in Medicine
#35
REVIEW
Karla Estefanía-Fernández, Ane Andrés, Alida Alcolea, María Velayos-López, Laura G Pastrían, Carla Ramírez-Amorós, Rocío Gonzalez, Marta Sarría, Esther Ramos, Manuel López-Santamaria, Francisco Hernández
BACKGROUND: MRS/MFS is a rare multisystem disorder with a poor prognosis. The high mortality rate of this syndrome is related to the severity of the associated gastrointestinal, pancreatic, and hepatobiliary conditions, as most of them are not amenable to conventional medical and surgical treatments. METHODS: We report the case of a Romani girl with all the key clinical features of MRS/MFS, and a review of cases reported in the literature. Our patient is a newborn from consanguineous parents who presented duodenal atresia, hypoplastic pancreas, gallbladder agenesis, and neonatal diabetes...
August 2022: Pediatric Transplantation
#36
REVIEW
Nicolas M Duchateau, Emilio Canovai, Rodrigo M Vianna, Tim Vanuytsel, Chris Verslype, George V Mazariegos, Diethard Monbaliu, Jacques Pirenne, Laurens J Ceulemans
BACKGROUND: Neuroendocrine tumors (NET) have an increasing incidence and are characterized by an invasive and metastatic presentation, rendering a curative resection not always feasible. For some patients the only life-saving option would be a multivisceral transplantation (MvTx). This systematic review aims to summarize the reported experience on combined liver-intestinal and MvTx for NET according PRISMA-guidelines. METHODS: PubMed, EMBASE and Cochrane Controlled Trial Reports were searched until April 7, 2020...
January 2022: Transplantation Reviews
#37
JOURNAL ARTICLE
Clarysse M, Wilmer A, Debaveye Y, Laleman W, Devos T, Canovai E, Verslype C, van der Merwe S, van Malenstein H, Nevens F, Maleux G, Sainz Barriga M, Monbaliu D, Pirenne J
No abstract text is available yet for this article.
July 1, 2021: Transplantation
#38
JOURNAL ARTICLE
Andres A, Hernandez-Oliveros F, Serradilla J, Sanchez-Galan A, Bueno A, Alcolea-Sanchez A, Gonzalez-Sacristan R, Ramos E, Prieto G, Lopez-Santamaria M
No abstract text is available yet for this article.
July 1, 2021: Transplantation
#39
JOURNAL ARTICLE
Serradilla J, Bueno A, Sánchez A, Andrés A, Alcolea A, González R, Ramos E, López-Santamaría M, Hernández-Oliveros F
No abstract text is available yet for this article.
July 1, 2021: Transplantation
#40
JOURNAL ARTICLE
Jafri S, Jafri S, Segovia M, Weiner J
No abstract text is available yet for this article.
July 1, 2021: Transplantation
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