Tyler W Benson, Kelsey A Conrad, Xinmin S Li, Zeneng Wang, Robert N Helsley, Rebecca C Schugar, Taylor M Coughlin, Caris Wadding-Lee, Salma Fleifil, Hannah M Russell, Timothy Stone, Michael Brooks, Jennifer A Buffa, Kevin Mani, Martin Björck, Anders Wanhainen, Naseer Sangwan, Sudha Biddinger, Rohan Bhandari, Akiirayi Ademoya, Crystal Pascual, W H Wilson Tang, Michael Tranter, Scott J Cameron, J Mark Brown, Stanley L Hazen, A Phillip Owens
BACKGROUND: Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) and several cardiometabolic diseases. This study aims to investigate the role of TMAO in the pathogenesis of abdominal aortic aneurysm (AAA) and target its parent microbes as a potential pharmacological intervention. METHODS: TMAO and choline metabolites were examined in plasma samples, with associated clinical data, from 2 independent patient cohorts (N=2129 total)...
April 4, 2023: Circulation