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pancreatitis AND aortic aneurysm

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https://www.readbyqxmd.com/read/28578083/lasagna-plots-to-visualize-results-in-surgical-studies
#1
Hamid Jalalzadeh, Sytse C van Beek, Reza Indrakusuma, Willem A Bemelman, Olivier R Busch, Ron Balm
BACKGROUND: A lasagna plot is a graphical tool that can display multiple longitudinal outcomes. To our knowledge, lasagna plots have not been used in publications of surgical studies before. The objective of this study was to demonstrate the results of surgical randomized controlled trials (RCTs) with lasagna plots in order to assess whether this can lead to new observations of the data presented in the original studies. MATERIAL AND METHODS: Lasagna plots were created with R for an RCT comparing endovascular and open repair for patients with a ruptured abdominal aortic aneurysm (AJAX trial), an RCT comparing laparoscopy or open surgery combined with either fast track or standard care for patients with colon cancer (LAFA trial) and an RCT comparing preoperative biliary drainage and early surgery for patients with pancreatic cancer (DROP trial)...
May 31, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28502074/causes-and-consequences-of-mesenteric-embolization-after-endovascular-aorto-iliac-intervention-a-nested-case-control-study
#2
Stefan Acosta, Jussi Kärkkäinen
BACKGROUND: Causes and consequences of mesenteric embolization after endovascular aorto-iliac procedures have not been studied adequately. METHODS: Consecutive patients with mesenteric embolization after endovascular aorto-iliac intervention between 2011 and 2015 (case-group, n = 9) were investigated and compared with age, gender and procedure-matched random controls (n = 36). RESULTS: Compared to the control group, a higher proportion of patients with mesenteric embolization were current smokers (89% vs...
May 14, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28434702/inhibition-or-deletion-of-angiotensin-ii-type-1-receptor-suppresses-elastase-induced-experimental-abdominal-aortic-aneurysms
#3
Haojun Xuan, Baohui Xu, Wei Wang, Hiroki Tanaka, Naoki Fujimura, Masaaki Miyata, Sara A Michie, Ronald L Dalman
OBJECTIVE: Angiotensin (Ang) II type 1 receptor (AT1) activation is essential for the development of exogenous Ang II-induced abdominal aortic aneurysms (AAAs) in hyperlipidemic animals. Experimental data derived from this modeling system, however, provide limited insight into the role of endogenous Ang II in aneurysm pathogenesis. Consequently, the potential translational value of AT1 inhibition in clinical AAA disease management remains incompletely understood on the basis of the existing literature...
April 20, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28377069/inflammatory-cytokines-and-angiogenic-factors-as-potential-biomarkers-in-south-african-pancreatic-ductal-adenocarcinoma-patients-a-preliminary-report
#4
Yandiswa Y Yako, Martin Brand, Martin Smith, Deirdré Kruger
BACKGROUND/OBJECTIVES: Several studies have investigated the association of differentially expressed cytokines with pancreatic ductal adenocarcinoma (PDAC), but none in African countries. This study aimed at investigating T-helper (Th) cell and angiogenic markers as diagnostic or prognostic biomarkers for PDAC in Black South Africans. METHODS: We conducted a prospective, case-control study comprising of 34 PDAC patients and 27 control participants with either critical limb ischemia, abdominal aortic aneurysm or other abdominal pathology from causes other than pancreatic disease...
March 9, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28155626/serum-calprotectin-as-a-novel-biomarker-in-abdominal-aortic-aneurysm-pathogenesis-and-progression-preliminary-data-from-experimental-model-in-rats
#5
Demetrios Moris, Stamatios Theocharis, Spyridon Davakis, Nikolaos Patelis, Georgios Agrogiannis, Ioannis S Vlachos, Eleftherios Spartalis, Antonios Athanasiou, Chris Bakoyiannis, Despina N Perrea, Sotirios Georgopoulos
BACKGROUND: Abdominal aortic aneurysm (AAA) formation is associated with by inflammation and matrix degradation. This study tested the hypothesis that calprotectin, a novel biomarker for inflammation, as well as established biomarkers such as C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) could also be indicative inflammatory biomarkers during AAA pathogenesis and progression. We also evaluated the correlation of serum soluble Receptor for Advanced Glycation End Products (sRAGE) with AAA diameter and serum calprotectin levels...
February 2, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28024851/deficiency-of-%C3%AE-%C3%AE-t-cells-protects-against-abdominal-aortic-aneurysms-by-regulating-phosphoinositide-3-kinase-akt-signaling
#6
Shuai Zhang, Xiaoyu Kan, Yulin Li, Ping Li, Congcong Zhang, Guang Li, Jie Du, Bin You
OBJECTIVE: It is known that T lymphocytes are activated in human abdominal aortic aneurysms (AAAs). γδT cells, as a subset of T cells, play a role in many inflammation-related diseases. However, whether γδT cells participate in the formation of AAA remains unknown. In this study, we explored the role of γδT cells in AAA lesions. METHODS AND RESULTS: Using the porcine pancreatic elastase-induced AAA model, we found that knock out of γδT cells significantly attenuated AAA formation...
December 23, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28017813/association-between-state-medical-malpractice-environment-and-postoperative-outcomes-in-the-united-states
#7
Christina A Minami, Catherine R Sheils, Emily Pavey, Jeanette W Chung, Jonah J Stulberg, David D Odell, Anthony D Yang, David J Bentrem, Karl Y Bilimoria
BACKGROUND: The US medical malpractice system assumes that the threat of liability should deter negligence, but it is unclear whether malpractice environment affects health care quality. We sought to explore the association between state malpractice environment and postoperative complication rates. STUDY DESIGN: This observational study included Medicare fee-for-service beneficiaries undergoing one of the following operations in 2010: colorectal, lung, esophageal, or pancreatic resection, total knee arthroplasty, craniotomy, gastric bypass, abdominal aortic aneurysm repair, coronary artery bypass grafting, or cystectomy...
March 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27790959/igg4-related-syndrome-another-multiorgan-disease-in-the-interest-field-of-internal-medicine
#8
Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Tiziana Di Chiara, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo, Antonio Pinto
BACKGROUND: IgG4-related disease is a rare, clinical and pathologic disease entity of unknown etiology. Its main features are increased serum concentrations of IgG4 > 1,35 g/l, lymphocyte and IgG4+plasma-cell infiltration within tissues, fibrosis or sclerosis. The classical presentation of IgG4-RSD is pancreatitis which is combined with the involvement of biliary ducts in 74 percent of patients. Extrapancreatic manifestations include: abdominal or mediastinal lymphadenopathy; the involvement of salivary glands and lacrimal glands, kidneys, lung, retroperitoneum...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27738465/pancreatic-arcade-artery-aneurysm-a-rare-complication-after-replacement-of-thoracoabdominal-aortic-aneurysm
#9
Mitsuru Sato, Shunsuke Kawamoto, Yoshikatsu Saiki
Aneurysm in the pancreatic arcade artery is an uncommon event, and is usually associated with the condition of median arcuate ligament syndrome. The stenosis at the base of the celiac axis has been presumed to be attributable to a relative increase in flow and pressure within the pancreatic arcade, resulting in subsequent development of the aneurysm. We, herein, present a rare case with rapid development of a pancreatic arcade artery aneurysm immediately after the replacement of a thoracoabdominal aortic aneurysm...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/27532120/extra-and-intraluminal-elastase-induce-morphologically-distinct-abdominal-aortic-aneurysms-in-mice-and-thus-represent-specific-subtypes-of-human-disease
#10
COMPARATIVE STUDY
Albert Busch, Amina Holm, Nicole Wagner, Süleyman Ergün, Mathias Rosenfeld, Christoph Otto, Johannes Baur, Richard Kellersmann, Udo Lorenz
Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, inflammation, and angiogenesis as distinct features of aneurysms in two models treated with intra-/extraluminal elastase. C57BL/6 mice underwent intra-/extraluminal elastase application via laparotomy and were followed up for 4 weeks...
2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27504274/unusual-variation-in-the-branching-pattern-of-the-celiac-trunk-and-its-embryological-and-clinical-perspective
#11
Shilpi Agarwal, Babita Pangtey, Neelam Vasudeva
Knowledge of variations in the branching pattern of Celiac Trunk (CT) is important for surgeries of stomach, duodenum, pancreas and hepatobiliary region, for abdominal aortic aneurysm, for liver transplant and chaemoembolization of hepatic tumours. An unusual variation in the branching pattern of CT was observed in 50-year-old male cadaver of Indian origin. CT divided into six branches out of which right & left inferior phrenic arteries originated as first two branches and left gastric artery as the third branch...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27444190/surgeon-specialization-and-operative-mortality-in-united-states-retrospective-analysis
#12
Nikhil R Sahni, Maurice Dalton, David M Cutler, John D Birkmeyer, Amitabh Chandra
OBJECTIVE:  To measure the association between a surgeon's degree of specialization in a specific procedure and patient mortality. DESIGN:  Retrospective analysis of Medicare data. SETTING:  US patients aged 66 or older enrolled in traditional fee for service Medicare. PARTICIPANTS:  25 152 US surgeons who performed one of eight procedures (carotid endarterectomy, coronary artery bypass grafting, valve replacement, abdominal aortic aneurysm repair, lung resection, cystectomy, pancreatic resection, or esophagectomy) on 695 987 patients in 2008-13...
July 21, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27429809/not-all-acute-abdomen-cases-in-early-pregnancy-are-ectopic-expect-the-unexpected-renal-angiomyolipoma-causing-massive-retroperitoneal-haemorrhage
#13
Muhammad Asim Rana, Ahmed F Mady, Nagesh Jakaraddi, Shahzad A Mumtaz, Habib Ahmad, Kamal Naser
Retroperitoneal haemorrhage (or retroperitoneal haematoma) refers to an accumulation of blood found in the retroperitoneal space. It is a rare clinical entity with variable aetiology including anticoagulation, ruptured aortic aneurysm, acute pancreatitis, malignancy, and bleeding from renal aneurysm. Diagnosis of retroperitoneal bleed is sometimes missed or delayed as presentation is often nonspecific. Multislice CT and arteriography are important for diagnosis. There is no consensus about the best management plan for patients with retroperitoneal haematoma...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27423722/repair-of-a-contained-ruptured-paravisceral-aortic-aneurysm-using-a-surgeon-modified-fenestrated-endograft-and-development-of-an-aortogastric-fistula
#14
Franziska Heidemann, Holger Diener, Sebastian Debus, Daniel Perez, Tilo Kölbel, Nikolaos Tsilimparis
Complex aortic aneurysms such as paravisceral aneurysm represent a challenging condition especially in the case of rupture. The presence of an aortoenteric fistula in this setting is associated with a very high mortality and morbidity. We report the case of a 72-year-old patient with contained ruptured paravisceral aortic aneurysm who underwent surgeon-modified fenestrated endovascular aneurysm repair (sm-fEVAR) with fenestrations for multiple renal arteries and the superior mesenteric artery. The patient successfully recovered from the repair but developed an aortogastric fistula on the basis of a preexisting gastric ulceration so that second-stage atypical gastrectomy was conducted...
October 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27350843/acute-pancreatitis-complicated-by-rupture-of-abdominal-aortic-aneurysm
#15
Krzysztof Wachal, Zbigniew Krasiński, Krzysztof Szmyt, Jacek Białecki, Sylwia Sławek, Grzegorz Oszkinis
No abstract text is available yet for this article.
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27318339/-the-significance-of-a-4-183-da-peptide-of-dermcidin-protein-in-the-early-diagnosis-and-differential-diagnosis-of-acute-coronary-syndrome
#16
Feng Kai, Liu Lifeng, Song Haijing, Liu Xianhua, Xia Hu
OBJECTIVE: To investigate the predictive value of 4,183 Da peptide of dermcidin protein in the early diagnosis and differential diagnosis of ischemic heart disease. METHODS: A prospective controlled study was conducted. Serum samples were drawn from 161 patients with acute coronary'syndrome [ACS, including 46 patients with unstable angina (UA), 23 with acute non-ST elevation myocardial infarction, and 92 with acute ST segment elevation myocardial infarction], 111 subjects for routine physical examination, including 45 patients with hypertension history, 42 with coronary heart disease, 22 with diabetes, and 54 patients with non-ACS (including pulmonary embolism, aortic dissection, aneurysm, arrhythmia, myocarditis, coronary myocardial bridge, pleurisy, pneumothorax pneumomediastinum, rib fracture, reflux esophagitis, peptic ulcer, and pancreatitis) to serve as controls...
December 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27160753/a-case-report-of-igg4-related-syndrome-and-literature-review
#17
Antonino Tuttolomondo, Irene Simonetta, Domenico Di Raimondo, Roberta Conigliaro, Francesca Corpora, Valerio Vassallo, Antonio Pinto
BACKGROUND: IgG4-related disease is a rare, clinical and pathologic disease entity of unknown etiology. Its main features are increased serum concentrations of IgG4 > 1,35 g/l, lymphocyte and IgG4+plasma-cell infiltration within tissues, fibrosis or sclerosis. The classical presentation of IgG4-RSD is pancreatitis which is combined with the involvement of biliary ducts in 74 percent of patients. Extrapancreatic manifestations include: abdominal or mediastinal lymphadenopathy; the involvement of salivary glands and lacrimal glands, kidneys, lung, retroperitoneum...
May 10, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26994132/off-hour-admission-and-mortality-risk-for-28-specific-diseases-a-systematic-review-and-meta-analysis-of-251-cohorts
#18
REVIEW
Yanfeng Zhou, Wenzhen Li, Chulani Herath, Jiahong Xia, Bo Hu, Fujian Song, Shiyi Cao, Zuxun Lu
BACKGROUND: A considerable amount of studies have examined the relationship between off-hours (weekends and nights) admission and mortality risk for various diseases, but the results remain equivocal. METHODS AND RESULTS: Through a search of EMBASE, PUBMED, Web of Science, and Cochrane Database of Systematic Reviews, we identified cohort studies that evaluated the association between off-hour admission and mortality risk for disease. In a random effects meta-analysis of 140 identified articles (251 cohorts), off-hour admission was strongly associated with increased mortality for aortic aneurysm (odds ratio, 1...
March 18, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26894432/heme-oxygenase-1-expression-affects-murine-abdominal-aortic-aneurysm-progression
#19
Junya Azuma, Ronald J Wong, Takeshi Morisawa, Mark Hsu, Lars Maegdefessel, Hui Zhao, Flora Kalish, Yosuke Kayama, Matthew B Wallenstein, Alicia C Deng, Joshua M Spin, David K Stevenson, Ronald L Dalman, Philip S Tsao
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli. Human genetic data suggest that a diminished HO-1 expression may predispose one to abdominal aortic aneurysm (AAA) development. In addition, heme is known to strongly induce HO-1 expression. Utilizing the porcine pancreatic elastase (PPE) model of AAA induction in HO-1 heterozygous (HO-1+/-, HO-1 Het) mice, we found that a deficiency in HO-1 leads to augmented AAA development...
2016: PloS One
https://www.readbyqxmd.com/read/26817611/pharmacologic-blockade-and-genetic-deletion-of-androgen-receptor-attenuates-aortic-aneurysm-formation
#20
John P Davis, Morgan Salmon, Nicolas H Pope, Guanyi Lu, Gang Su, Akshaya Meher, Gorav Ailawadi, Gilbert R Upchurch
BACKGROUND: Testosterone is theorized to play a major role in the pathophysiology of abdominal aortic aneurysms (AAAs) because this disease occurs primarily in men. The role of the androgen receptor (AR) in the formation of AAAs has not been well elucidated, and therefore, it is hypothesized that androgen blockade will attenuate experimental aortic aneurysm formation. METHODS: Aortas of 8- to 12-week-old male C57Bl/6 wild-type (WT) mice or male AR knockout (AR(-/-)) mice were perfused with purified porcine pancreatic elastase (0...
June 2016: Journal of Vascular Surgery
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