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JOURNAL ARTICLE
Han Wu, Hui Wang, Lixia Sun, Mengchen Liu, Haoran Wang, Xianchang Sun, Wenjuan Zhang
PURPOSE: To study the relationship between the single nucleotide polymorphism (SNP) rs2278426 in the angiopoietin-like protein 8 gene ( ANGPTL8 ) and polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: A total of 122 patients with PCOS and 108 controls were recruited for comparison of glucose, lipid, insulin, sex hormone, and ANGPTL8 levels. Polymerase chain reaction (PCR) and gene sequencing were performed for comparison of the frequency of the CC, CT, and TT rs2278426 genotypes and the rs2278426 allele distributions between the PCOS and control groups and between the obese and non-obese subgroups of the PCOS and control groups...
2024: Diabetes, Metabolic Syndrome and Obesity
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JOURNAL ARTICLE
Novaria Sari Dewi Panjaitan, Sarwo Handayani, Christina Safira Whinie Lestari
No abstract text is available yet for this article.
2024: Diabetes, Metabolic Syndrome and Obesity
#23
JOURNAL ARTICLE
Ji-Eun Oh, Sung Ryul Yu, Jung-Yoon Yoo, Kyung-A Shin
PURPOSE: Visceral fat accumulation can negatively affect uric acid metabolism in healthy adults. The hypertriglyceridemic-waist (HTGW) phenotype is a predictor of diabetes and cardiometabolic risk. This study aimed to investigate the association between the HTGW phenotype and asymptomatic hyperuricemia in Korean adults. PATIENTS AND METHODS: The study included 23,240 adults, aged 20-80 years who underwent comprehensive health examinations at a general hospital in Gyeonggi Province, Korea, from January 2020 to December 2022...
2024: Diabetes, Metabolic Syndrome and Obesity
#24
JOURNAL ARTICLE
Wenjian Li
No abstract text is available yet for this article.
2024: Diabetes, Metabolic Syndrome and Obesity
#25
JOURNAL ARTICLE
Vahid Akheratdoost, Negar Panahi, Shahabeddin Safi, Faraz Mojab, Ghasem Akbari
OBJECTIVES: Obesity is a metabolic syndrome that leads to many chronic diseases worldwide. In this study, we investigate the antihyperlipidemic activities of chitosan nanoparticles (CH NPs) on silymarin (SIL) as a carrier in the drug delivery system that can improve some biochemical parameters and hormones in the model of hyperlipidemic rats receiving a high-fat diet (HFD). MATERIALS AND METHODS: Physicochemical characterization of silymarin-loaded chitosannanoparticles (CH-SIL NPs) was done by Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), and drug loading efficiency (LE)...
2024: Iranian Journal of Basic Medical Sciences
#26
JOURNAL ARTICLE
Piotr K Krajewski, Łukasz Matusiak, Sascha Ständer, Diamant Thaçi, Jacek C Szepietowski, Henner Zirpel
BACKGROUND: Patients with hidradenitis suppurativa (HS) often suffer from comorbid diabetes, metabolic syndrome, and hyperlipidemia and, therefore, are susceptible to the development of cardiovascular diseases (CVDs). Moreover, systemic inflammation plays a vital role in the development of atherosclerosis. The creation of atherosclerotic plaque is characterized by endothelial dysfunction driven by elevated concentrations of interleukin (IL)-1, IL-6, and IL-18 among others, as well as tumor necrosis factor (TNF) alpha...
April 21, 2024: International Journal of Dermatology
#27
REVIEW
Pengfei Cui, Xiaoyi Li, Caihua Huang, Donghai Lin
Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing a significant burden on the health and survival of cancer patients. Despite ongoing efforts, effective treatments for CC are still lacking. Metabolomics, an advanced omics technique, offers a comprehensive analysis of small-molecule metabolites involved in cellular metabolism. In CC research, metabolomics has emerged as a valuable tool for identifying diagnostic biomarkers, unravelling molecular mechanisms and discovering potential therapeutic targets...
April 21, 2024: Journal of Cachexia, Sarcopenia and Muscle
#28
JOURNAL ARTICLE
Guillem Cuatrecasas, Marta Calbo, Olga Rossell, Laia Dachs, Gerardo Aguilar-Soler, Maria-José Coves, Ioana Patrascioiu, Camila Eugenia Benito, Sonia March, Mariona Balfegó, Gabriel Cuatrecasas, Silvana Di Gregorio, Inaki Marina, Pilar Garcia-Lorda, Elena Munoz-Marron, Francisco De Cabo
INTRODUCTION: Ultrasonography in patients with Obesity allows us to measure different layers of abdominal fat (Superficial subcutaneous, Deep subcutaneous, Preperitoneal, Omental and Perirenal), not assessable by DEXA or CT scan. Omental and Perirenal fat depots are considered predictors of metabolic complications. Liraglutide is particularly effective in reducing weight in patients with insulin-resistance, but its direct impact on each abdominal fat layer is unknown. METHODS: We measured, at the L4 level, all 5 abdominal fat depots in 860 patients with obesity (72...
April 20, 2024: Obesity Facts
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JOURNAL ARTICLE
Chatchon Kaewkrasaesin, Weerapat Kositanurit, Phawinpon Chotwanvirat, Nitchakarn Laichuthai
BACKGROUND AND AIMS: Hyperglycemic crisis is a metabolic catastrophe which can occur in any type of diabetes. In 2019, the World Health Organization (WHO) revised the classification of diabetes mellitus (DM) and established two new hybrid forms, latent autoimmune diabetes in adults (LADA) and ketosis-prone type 2 diabetes (T2D). This study aimed to determine clinical outcomes after a hyperglycemic crisis event in people with diabetes classified subtypes by 2019 WHO DM classification. METHODS: A five-year (2015-2019) retrospective study of adult patients admitted with hyperglycemic crises was conducted...
April 15, 2024: Diabetes & Metabolic Syndrome
#30
JOURNAL ARTICLE
Yuji Ito, Tadashi Ito, Sho Narahara, Hideshi Sugiura, Yuichiro Sugiyama, Tetsuo Hattori, Hiroyuki Kidokoro, Takeshi Tsuji, Tetsuo Kubota, Jun Natsume, Koji Noritake, Nobuhiko Ochi
BACKGROUND: This cross-sectional study compared body composition and motor function between children who were born large for gestational age (LGA) and those born appropriate for gestational age (AGA) and to investigate the association between gait quality and other variables. METHODS: Body composition was determined using a bioelectrical impedance analyzer. Motor functions were assessed using one-leg standing time, timed up-and-go test, five times sit-to-stand test, and three-dimensional gait analysis...
April 20, 2024: Pediatric Research
#31
JOURNAL ARTICLE
Yuanyuan Jiao, Xinze Liu, Jingxuan Shi, Jiaqi An, Tianyu Yu, Guming Zou, Wenge Li, Li Zhuo
BACKGROUND: Diabetic kidney disease (DKD) is a primary microvascular complication of diabetes with limited therapeutic effects. Delving into the pathogenic mechanisms of DKD and identifying new therapeutic targets is crucial. Emerging studies reveal the implication of ferroptosis and immune dysregulation in the pathogenesis of DKD, however, the precise relationship between them remains not fully elucidated. Investigating their interplay is pivotal to unraveling the pathogenesis of diabetic kidney disease, offering insights crucial for targeted interventions and improved patient outcomes...
April 20, 2024: Diabetology & Metabolic Syndrome
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JOURNAL ARTICLE
Xike Mao, Yuehan Yang, Junping Yang, Mingwei Chen, Zongyao Hao
OBJECTIVE: This study aimed to evaluate the potential association between the body roundness index (BRI) and kidney stone prevalence in adults in the United States. METHODS: A cohort of participants from the National Health and Nutrition Examination Survey (NHANES) database spanning 2007-2018 were gathered for analysis. Logistic regression analyses, subgroup assessments, and calculations were employed to examine the potential link between BRI and kidney stone prevalence...
April 20, 2024: BMC Urology
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JOURNAL ARTICLE
Laura Álvarez-Álvarez, María Rubín-García, Facundo Vitelli-Storelli, Silvia García, Cristina Bouzas, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Mireia Malcampo, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Lapetra, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Camino García Fernández, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Ana García-Arellano, María Ángeles Martínez, José V Sorlí, María Dolores Zomeño, Antonio García-Rios, Sandra González-Palacios, Margalida Monserrat-Mesquida, Itziar Abete, Antoni Colom Fernández, Rosa Casas, Naomi Cano Ibañez, Lucía Ugarriza, M Rosa Bernal-López, Maira Bes-Rastrollo, Indira Paz-Graniel, Eva M Asensio, Montse Fitó, Antonio P Arenas Larriva, Alejandro Oncina-Cánovas, Zenaida Vázquez, María Fernández de la Puente, Alejandra Pérez-Vega, Josep A Tur, Vicente Martín-Sánchez
OBJECTIVE: To estimate the environmental impact of a dietary intervention based on an energy-reduced Mediterranean diet (MedDiet) after one year of follow-up. METHODS: Baseline and 1-year follow-up data were used for 5800 participants aged 55-75 years with metabolic syndrome in the PREDIMED-Plus study. Food intake was estimated through a validated semiquantitative food consumption frequency questionnaire, and adherence to the MedDiet was estimated through the Diet Score...
April 18, 2024: Science of the Total Environment
#34
REVIEW
Athirah Sorfina Sa'ari, Mohd Ramadan Ab Hamid, Nurul 'Ain Azizan, Nazrul Hadi Ismail
Screen time (ST) on digital devices has increased in recent decades due to digital development. Furthermore, constant engagement with digital devices alters sleep patterns, leading to nocturnal eating behaviour among users. These phenomena are therefore of great concern, as digital device addiction and night eating are associated with unhealthy food intake, increasing the metabolic syndrome (MetS) risks. The purpose of this review was to examine the evidence of the influence of ST and night eating behaviour (NEB) on dietary intake and its association with MetS based on previous literature...
April 17, 2024: Physiology & Behavior
#35
REVIEW
Jared Gabriel L Dela Rosa, Charlene Divine M Catral, Nico Alexander Reyes, Danna Mae S Opiso, Erika P Ong, Eric David B Ornos, Jerico R Santos, Elgin Paul B Quebral, Maria Llaine J Callanta, Raymond V Oliva, Ourlad Alzeus G Tantengco
AIMS: In this paper, we discuss the existing data on the burden of hypertension in the Philippines and present the status of management, prevention, and control of hypertension in the country. METHODS: A literature review was conducted to synthesize the status of hypertension care in the Philippines. RESULTS: Hypertension continues to contribute to the country's leading causes of death. Similar to the global trend, almost half of hypertensive Filipinos are still not aware of their condition, and only 27 % have it under control...
April 16, 2024: Diabetes & Metabolic Syndrome
#36
JOURNAL ARTICLE
Lingzhi Wang, Wenxi Li, Yinggang Li, Gengrui Chen, Lijuan Zhao, Wu Li, Shengwei Wang, Chunming Wang, Yanxian Feng, Yibo Zhang
Non-alcoholic fatty liver disease (NAFLD) is a complex pathogenic metabolic syndrome characterized by increased inflammation and endoplasmic reticulum stress. In recent years, natural polysaccharides derived from traditional Chinese medicine have shown significant anti-inflammatory effects, making them an attractive therapeutic option. However, little research has been conducted on the therapeutic potential of dried tangerine peel polysaccharide (DTPP) - one of the most important medicinal resources in China...
April 16, 2024: Bioorganic Chemistry
#37
JOURNAL ARTICLE
Liam R Brunham
PURPOSE OF REVIEW: The purpose of this review article was to describe recent advances in our knowledge about how diabetes and metabolic syndrome are changing the face of familial hypercholesterolemia. RECENT FINDINGS: Heterozygous familial hypercholesterolemia, most commonly caused by disruption to LDL receptor function, leads to lifelong elevation of LDL cholesterol and increased risk of atherosclerotic cardiovascular disease. Familial hypercholesterolemia was originally described as a form of 'pure' hypercholesterolemia, in the sense that levels of LDL were uniquely affected...
April 22, 2024: Current Opinion in Lipidology
#38
JOURNAL ARTICLE
S Genc, B Evren, M N Aydın, I Sahin
OBJECTIVE: Prediabetes accompanied by metabolic syndrome accelerates the process leading to diabetes and causes an increase in complications. The current study aimed to investigate the clinical conditions accompanying prediabetes and the effect of the association of metabolic syndrome on clinical outcomes in prediabetics. SUBJECTS AND METHODS: This cross-sectional study was conducted with 88 prediabetic individuals between November 2022 and January 2023. Prediabetes was diagnosed using the American Diabetes Association (ADA) criteria, and metabolic syndrome was diagnosed using the International Diabetes Federation criteria...
April 2024: European Review for Medical and Pharmacological Sciences
#39
JOURNAL ARTICLE
Junki Miyamoto, Yuna Ando, Akari Nishida, Mayu Yamano, Shunsuke Suzuki, Hiromi Takada, Ikuo Kimura
SCOPE: Obesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)-supplemented diet may ameliorate obesity and other metabolic disorders. Although accumulating evidence supports the notion of the developmental origins of health and disease, the underlying mechanisms remain obscure...
April 19, 2024: Molecular Nutrition & Food Research
#40
JOURNAL ARTICLE
Jaouad Bouayed, Farhad Vahid
Carotenoids are generally associated with health-beneficial effects; however, their intake patterns related to metabolic syndrome (MetS) and its components remains controversial. This cross-sectional study investigated associations between dietary intakes of individual carotenoids, fruits and vegetables, and the MetS and its components. Dietary intakes of 1346 participants of the ORISCAV-LUX-2 study were investigated by a 174 item-food frequency questionnaire, and carotenoid intake was determined by linking findings using mainly the USDA food databases...
April 19, 2024: British Journal of Nutrition
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