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https://www.readbyqxmd.com/read/29691142/oxidative-stress-biomarkers-and-clinical-dimensions-in-first-10-years-of-schizophrenia
#1
Leticia González-Blanco, María Paz García-Portilla, Leticia García-Álvarez, Lorena de la Fuente-Tomás, Celso Iglesias García, Pilar A Sáiz, Susana Rodríguez-González, Ana Coto-Montes, Julio Bobes
INTRODUCTION: Several studies have described increased oxidative stress parameters in patients with schizophrenia. The objectives of the current study were to identify potential oxidative stress biomarkers in stable patients during first 10 years of schizophrenia and determine if they are associated with specific clinical dimensions. MATERIAL AND METHODS: Seventy-three clinically stable outpatients with schizophrenia and 73 sex and age-matched healthy controls were recruited...
April 21, 2018: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29689315/stress-as-risk-factor-for-alzheimer-s-disease
#2
REVIEW
Alessandra Caruso, Ferdinando Nicoletti, Dalila Mango, Amira Saidi, Rosamaria Orlando, Sergio Scaccianoce
Prolonged stress predisposes susceptible individuals to a number of physiological disorders including cardiovascular disease, obesity and gastrointestinal disorders, as well as psychiatric and neurodegenerative disorders. Preclinical studies have suggested that manipulation of the glucocorticoid milieu can trigger cellular, molecular and behavioral derangement resembling the hallmarks of Alzheimer's Disease (AD). For example, stress or glucocorticoid administration can increase amyloid ß precursor protein and tau phosphorylation which are involved in synaptic dysfunction and neuronal death associated with AD...
April 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29688806/relationships-among-c-reactive-protein-alanine-aminotransferase-and-metabolic-syndrome-in-apparently-healthy-chinese-subjects
#3
Hsin-Hung Huang, Yen-Lin Chen, Jin-Shuen Chen, Jiunn-Diann Lin, Chang-Hsun Hsieh, Dee Pei, Chung-Ze Wu
AIM: Elevated levels of C-reactive protein (CRP) and alanine aminotransferase (ALT) are tightly associated with metabolic syndrome (MetS). However, it is unclear whether the combination of normal CRP and ALT increases probability of the presence of MetS. MATERIALS AND METHODS: We enrolled 433 Chinese in health screening with both CRP and ALT in normal range. They were divided into four groups: both low (BL, both low baseline CRP and ALT), only high CRP (HCRP), only high ALT (HALT), and both high (BH, both high baseline CRP and ALT) in different genders...
April 24, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29688799/gender-differences-in-the-effects-of-the-frequency-of-physical-activity-on-the-incidence-of-metabolic-syndrome-results-from-a-middle-aged-community-cohort-in-taiwan
#4
Sheng-Pyng Chen, Huan-Cheng Chang, Tien-Mu Hsiao, Chih-Jung Yeh, Hao-Jan Yang
BACKGROUND: Little is known about how the frequency of physical activity in adults influences the occurrence of metabolic syndrome (MetS), and whether there are gender differences within these effects. METHODS: In this study, 3368 residents from the established "Landseed Cohort" underwent three waves of health examinations, and those who did not have MetS at baseline were selected and analyzed using a multiple Poisson regression model. By calculating the adjusted relative risk (ARR), the linear and nonlinear relationships between the frequency of physical activity and risk of developing MetS were examined for male and female participants...
April 24, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29688336/nonalcoholic-fatty-liver-disease-in-inflammatory-bowel-disease-prevalence-and-risk-factors
#5
Principi Mariabeatrice, Iannone Andrea, Losurdo Giuseppe, Mangia Michela, Shahini Endrit, Albano Francesca, Salvatore Fabio Rizzi, Rosa Federica La Fortezza, Lovero Rosa, Contaldo Antonella, Barone Michele, Leandro Gioacchino, Ierardi Enzo, Di Leo Alfredo
Background: Nonalcoholic fatty liver disease (NAFLD) is common in inflammatory bowel diseases (IBD). Herein, NAFLD prevalence and risk factors in a large IBD cohort were evaluated and compared to that of a non-IBD sample. Methods: Crohn's disease/ulcerative colitis outpatients referred to IBD service of our Gastroenterology Unit were enrolled. Subjects affected by functional and motor gastrointestinal disorders, in whom IBD was ruled out, referred to general outpatient service in the same area, were considered as nonIBD group...
April 23, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29688015/a-peripherally-restricted-purine-antagonist-of-type-1-cannabinoid-cb1-receptor-blocks-alcoholic-steatosis-in-mice
#6
George Amato, Amruta Manke, Danni L Harris, Robert W Wiethe, Vineetha Vasukuttan, Rodney W Snyder, Timothy W Lefever, Ricardo Cortes, Yanan Zhang, Shaobin Wang, Scott P Runyon, Rangan Maitra
Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome and dyslipidemias. However, inhibition of CB1 receptors in the central nervous system can produce adverse effects including depression, anxiety and suicidal ideation. Efforts are now underway to produce peripherally restricted CB1 antagonists to circumvent CNS-associated undesirable effects. In this study, a series of analogs were explored in which the 4-aminopiperidine group of 2 was replaced with aryl and heteroaryl substituted piperazine groups both with and without a spacer...
April 24, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29687952/the-metabolic-syndrome-and-the-prostate
#7
EDITORIAL
Peter J Gilling
No abstract text is available yet for this article.
May 2018: BJU International
https://www.readbyqxmd.com/read/29687904/unitary-physiology
#8
John S Torday, William B Miller
The common relationships among a great variety of biological phenomena seem enigmatic when considered solely at the level of the phenotype. The deep connections in physiology, for example, between the effects of maternal food restriction in utero and the subsequent incidence of metabolic syndrome in offspring, the effects of microgravity on cell polarity and reproduction in yeast, stress effects on jellyfish, and their endless longevity, or the relationship between nutrient abundance and the colonial form in slime molds, are not apparent by phenotypic observation...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29687761/uric-acid-nephrolithiasis-an-update
#9
Elisa Cicerello
Uric acid nephrolithiasis appears to increase in prevalence. While a relationship between uric acid stones and low urinary pH has been for long known, additional association with various metabolic conditions and pathophysiological basis has recently been elucidated. Some conditions such as diabetes and metabolic syndrome disease, excessive dietary intake, and increased endogenous uric acid production and/or defect in ammoniagenesis are associated with low urinary pH. In addition, the phenomenon of global warming could result in an increase in areas with greater climate risk for uric acid stone formation...
April 1, 2018: Urologia
https://www.readbyqxmd.com/read/29687018/diabetes-and-obesity-are-the-main-metabolic-drivers-of-peripheral-neuropathy
#10
Brian C Callaghan, LeiLi Gao, Yufeng Li, Xianghai Zhou, Evan Reynolds, Mousumi Banerjee, Rodica Pop-Busui, Eva L Feldman, Linong Ji
Objective: To determine the associations between individual metabolic syndrome (MetS) components and peripheral neuropathy in a large population-based cohort from Pinggu, China. Methods: A cross-sectional, randomly selected, population-based survey of participants from Pinggu, China was performed. Metabolic phenotyping and neuropathy outcomes were performed by trained personnel. Glycemic status was defined according to the American Diabetes Association criteria, and the MetS using modified consensus criteria (body mass index instead of waist circumference)...
April 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29686546/usefulness-of-left-ventricular-mass-change-to-predict-progression-of-renal-dysfunction-in-hispanics
#11
Sarmad Said, Mohamed Teleb, Aymen Omar Albaghdadi, Obiajulu Kanu, Miraie Wardi, Kyari Sumayin Ngamdu, Lutf Rahman Sroush, Majd Michael, Asmik Asatrian, Riyadh Salih Salman, Debabrata Mukherjee
There is a strong relation between metabolic syndrome (MetS) and left ventricular (LV) mass in Hispanic patients. This population also tends to have a higher incidence of kidney disease, with progression to dialysis. We analyzed the change in LV mass in 982 Hispanic patients with MetS and used these data to anticipate the progression of renal dysfunction. Glomerular filtration rate (GFR) was calculated using the formula described by the Chronic Kidney Disease Epidemiology Collaboration. Echocardiographic data were collected using 2-dimensionally guided M-mode echocardiography measures...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29686319/allostatic-load-as-a-predictor-of-grey-matter-volume-and-white-matter-integrity-in-old-age-the-whitehall-ii-mri-study
#12
Enikő Zsoldos, Nicola Filippini, Abda Mahmood, Clare E Mackay, Archana Singh-Manoux, Mika Kivimäki, Mark Jenkinson, Klaus P Ebmeier
The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic load on the ageing brain has been limited. We investigated the relation of mid-life allostatic load index and multifactorial predictors of stroke (Framingham stroke risk) and diabetes (metabolic syndrome) with voxelwise structural grey and white matter brain integrity measures in the ageing Whitehall II cohort (N = 349, mean age = 69...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29686083/unexpected-metabolic-disorders-induced-by-endocrine-disruptors-in-xenopus-tropicalis-provide-new-lead-for-understanding-amphibian-decline
#13
Christophe Regnault, Marie Usal, Sylvie Veyrenc, Karine Couturier, Cécile Batandier, Anne-Laure Bulteau, David Lejon, Alexandre Sapin, Bruno Combourieu, Maud Chetiveaux, Cédric Le May, Thomas Lafond, Muriel Raveton, Stéphane Reynaud
Despite numerous studies suggesting that amphibians are highly sensitive to endocrine disruptors (EDs), both their role in the decline of populations and the underlying mechanisms remain unclear. This study showed that frogs exposed throughout their life cycle to ED concentrations low enough to be considered safe for drinking water, developed a prediabetes phenotype and, more commonly, a metabolic syndrome. Female Xenopus tropicalis exposed from tadpole stage to benzo( a )pyrene or triclosan at concentrations of 50 ng⋅L-1 displayed glucose intolerance syndrome, liver steatosis, liver mitochondrial dysfunction, liver transcriptomic signature, and pancreatic insulin hypersecretion, all typical of a prediabetes state...
April 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29684438/the-cytoskeleton-in-couch-potato-ism-insights-from-a-murine-model-of-impaired-actin-dynamics
#14
Karen Gertz, Ria Uhlemann, Anna Foryst-Ludwig, Ruben Marquina Barrientos, Kai Kappert, Christa Thöne-Reineke, Pierre Djoufack, Clemens Kirschbaum, Klaus B Fink, Andreas Heinz, Ulrich Kintscher, Matthias Endres, Golo Kronenberg
Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic syndrome. Using mice deficient in gelsolin (Gsn-/- ), a crucial actin-severing protein, we here investigated reduced actin turnover as a potential common driver of metabolic disturbances, sedentary behavior, and an anxious/depressive phenotype. Gelsolin deficiency resulted in reduced lifespan...
April 20, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#15
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29684136/effects-of-a-group-mediated-exercise-and-dietary-intervention-in-the-treatment-of-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-results-from-the-idea-p-trial
#16
Brian C Focht, Alexander R Lucas, Elizabeth Grainger, Christina Simpson, Ciaran M Fairman, Jennifer M Thomas-Ahner, Jackie Buell, J Paul Monk, Amir Mortazavi, Steven K Clinton
Background: Although androgen-deprivation therapy (ADT) is the foundation of treatment for prostate cancer, the physiological impacts of ADT result in functional decline and enhanced risk of chronic disease and metabolic syndrome. Purpose: The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) is a single-blind, randomized, pilot trial comparing the effects of a group-mediated, cognitive-behavioral (GMCB) exercise and dietary intervention (EX+D) with those of a standard-of-care (SC) control during the treatment of prostate cancer patients undergoing ADT...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29683445/assessing-collagen-and-elastin-pressure-dependent-microarchitectures-in-live-human-resistance-arteries-by-label-free-fluorescence-microscopy
#17
Maria Bloksgaard, Bjarne Thorsted, Jonathan R Brewer, Jo G R De Mey
The pathogenic contribution of resistance artery remodeling is documented in essential hypertension, diabetes and the metabolic syndrome. Investigations and development of microstructurally motivated mathematical models for understanding the mechanical properties of human resistance arteries in health and disease have the potential to aid understanding how disease and medical treatments affect the human microcirculation. To develop these mathematical models, it is essential to decipher the relationship between the mechanical and microarchitectural properties of the microvascular wall...
April 9, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29682733/upper-body-fat-predicts-metabolic-syndrome-similarly-in-men-and-women
#18
Scott M Grundy, Corbin Williams, Gloria L Vega
The metabolic syndrome is a constellation of risk factors including dyslipidemia, dysglycemia, hypertension, a pro-inflammatory state, and a prothrombotic state. All of these factors are accentuated by obesity. However, obesity can be defined by body mass index (BMI), percent body fat, or by body fat distribution. The latter consists of upper body fat (subcutaneous and visceral fat) and lower body fat (gluteofemoral fat). Waist circumference is a common surrogate marker for upper body fat. In this study, data from the National Health and Nutrition Examination Survey (NHANES) for the years 1999 - 2006 was examined for associations of metabolic risk factors with percent body fat, waist circumference, and BMI...
April 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29682581/diet-induced-abdominal-obesity-metabolic-changes-and-atherosclerosis-in-hypercholesterolemic-minipigs
#19
Ahmed Ludvigsen Al-Mashhadi, Christian Bo Poulsen, Karin von Wachenfeldt, Anna-Karin Robertson, Jacob Fog Bentzon, Lars Bo Nielsen, Jesper Thygesen, Lars Poulsen Tolbod, Jens Rolighed Larsen, Søren Kragh Moestrup, Björn Frendéus, Brynjulf Mortensen, Ludovic Drouet, Rozh H Al-Mashhadi, Erling Falk
Background: Obesity and metabolic syndrome (MetS) are major risk factors for atherosclerotic diseases; however, a causal link remains elusive. Animal models resembling human MetS and its complications, while important, are scarce. We aimed at developing a porcine model of human MetS. Methods: Forty pigs with familial hypercholesterolemia were fed a high fat + fructose diet for 30 weeks. Metabolic assessments and subcutaneous fat biopsies were obtained at 18 and 30 weeks, and fat distribution was assessed by CT-scans...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29681975/mind-body-therapies-for-african-american-women-at-risk-for-cardiometabolic-disease-a-systematic-review
#20
REVIEW
Candace C Johnson, Karen M Sheffield, Roy E Brown
Background: A major determinant in cardiometabolic health is metabolic syndrome (MetS), a cluster of symptoms that portend the development of cardiovascular disease (CVD). As mind-body therapies are thought to help in lowering physiological and environmental CVD risk factors including blood pressure and psychological stress, they may also be beneficial for the primary prevention of CVD. Objectives: To synthesize and summarize existing knowledge on the effectiveness of mind-body therapies on MetS outcomes in African-American (AA) women, a US subpopulation at high risk for CVD...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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