keyword
MENU ▼
Read by QxMD icon Read
search

Duchene

keyword
https://www.readbyqxmd.com/read/28227723/balance-quality-assessment-as-an-early-indicator-of-physical-frailty-in-older-people
#1
Aly Chkeir, Doha Safieddine, D Bera, M Collart, J L Novella, M Drame, David J Hewson, Jacques Duchene, Aly Chkeir, Doha Safieddine, D Bera, M Collart, J L Novella, M Drame, David J Hewson, Jacques Duchene, J L Novella, David J Hewson, Jacques Duchene, M Collart, Aly Chkeir, D Bera, M Drame, Doha Safieddine
Frailty is an increasingly common geriatric condition that results in an increased risk of adverse health outcomes such as falls. The most widely-used means of detecting frailty is the Fried phenotype, which includes several objective measures such as grip strength and gait velocity. One method of screening for falls is to measure balance, which can be done by a range of techniques including the assessment of the Centre of Pressure (CoP) during a balance assessment. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that can evaluate balance quality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217242/investigating-state-restriction-in-fluorescent-protein-fret-using-time-resolved-fluorescence-and-anisotropy
#2
Thomas S Blacker, WeiYue Chen, Edward Avezov, Richard J Marsh, Michael R Duchen, Clemens F Kaminski, Angus J Bain
Most fluorescent proteins exhibit multiexponential fluorescence decays, indicating a heterogeneous excited state population. FRET between fluorescent proteins should therefore involve multiple energy transfer pathways. We recently demonstrated the FRET pathways between EGFP and mCherry (mC), upon the dimerization of 3-phosphoinositide dependent protein kinase 1 (PDK1), to be highly restricted. A mechanism for FRET restriction based on a highly unfavorable κ(2) orientation factor arising from differences in donor-acceptor transition dipole moment angles in a far from coplanar and near static interaction geometry was proposed...
January 26, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28204787/inference-of-evolutionary-jumps-in-large-phylogenies-using-levy-processes
#3
Pablo Duchen, Christoph Leuenberger, Sandor M Szilagyi, Luke Harmon, Jonathan Eastman, Manuel Schweizer, Daniel Wegmann
No abstract text is available yet for this article.
February 16, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28178344/comparative-analysis-estimates-the-relative-frequencies-of-co-divergence-and-cross-species-transmission-within-viral-families
#4
Jemma L Geoghegan, Sebastián Duchêne, Edward C Holmes
The cross-species transmission of viruses from one host species to another is responsible for the majority of emerging infections. However, it is unclear whether some virus families have a greater propensity to jump host species than others. If related viruses have an evolutionary history of co-divergence with their hosts there should be evidence of topological similarities between the virus and host phylogenetic trees, whereas host jumping generates incongruent tree topologies. By analyzing co-phylogenetic processes in 19 virus families and their eukaryotic hosts we provide a quantitative and comparative estimate of the relative frequency of virus-host co-divergence versus cross-species transmission among virus families...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28158426/neutrophils-orchestrate-post-myocardial-infarction-healing-by-polarizing-macrophages-towards-a-reparative-phenotype
#5
Michael Horckmans, Larisa Ring, Johan Duchene, Donato Santovito, Maximilian J Schloss, Maik Drechsler, Christian Weber, Oliver Soehnlein, Sabine Steffens
No abstract text is available yet for this article.
January 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28132899/pathological-consequences-of-micu1-mutations-on-mitochondrial-calcium-signalling-and-bioenergetics
#6
Gauri Bhosale, Jenny Sharpe, Amanda Koh, Antonina Kouli, Gyorgy Szabadkai, Michael R Duchen
Loss of function mutations of the protein MICU1, a regulator of mitochondrial Ca(2+) uptake, cause a neuronal and muscular disorder characterised by impaired cognition, muscle weakness and an extrapyramidal motor disorder. We have shown previously that MICU1 mutations cause increased resting mitochondrial Ca(2+) concentration ([Ca(2+)]m). We now explore the functional consequences of MICU1 mutations in patient derived fibroblasts in order to clarify the underlying pathophysiology of this disorder. We propose that deregulation of mitochondrial Ca(2+) uptake through loss of MICU1 raises resting [Ca(2+)]m, initiating a futile Ca(2+) cycle, whereby continuous mitochondrial Ca(2+) influx is balanced by Ca(2+) efflux through the sodium calcium exchanger (NLCXm)...
January 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28111024/mitochondrial-dysfunction-and-neurodegeneration-in-lysosomal-storage-disorders
#7
REVIEW
Nicoletta Plotegher, Michael R Duchen
Lysosomal storage disorders (LSDs) are rare inherited debilitating and often fatal disorders. Caused by mutations affecting lysosomal proteins, LSDs are characterized by the accumulation of undegraded material in lysosomes and by lysosomal dysfunction. Although LSDs are multisystemic diseases, the majority display neurologic symptoms and neurodegeneration. Only recently has a role emerged for mitochondrial dysfunction in the pathophysiology of LSDs, suggesting an impact of lysosomal dysfunction on mitochondria...
January 19, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28006956/findings-and-impact-of-early-imaging-after-partial-nephrectomy
#8
Ryan W Tubre, William P Parker, Travis Dum, Tim Walmann, Zachary Hamilton, Moben Mirza, David A Duchene
INTRODUCTION: American Urological Association guidelines for surveillance of renal-cell carcinoma after partial nephrectomy recommend imaging within 3-12 months of surgery. Imaging following partial nephrectomy may be difficult to interpret due to the surgical defect, the use of surgical material, and normal postoperative fluid collections. Our primary objective was to evaluate the frequency of indeterminate postoperative imaging results and how those radiographic findings altered patient management...
January 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27977811/large-scale-phylogenomic-analysis-reveals-the-complex-evolutionary-history-of-rabies-virus-in-multiple-carnivore-hosts
#9
Cécile Troupin, Laurent Dacheux, Marion Tanguy, Claude Sabeta, Hervé Blanc, Christiane Bouchier, Marco Vignuzzi, Sebastián Duchene, Edward C Holmes, Hervé Bourhy
The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that underpin viral emergence. Using 321 genome sequences spanning an unprecedented diversity of RABV, we compared evolutionary rates and selection pressures in viruses sampled from multiple primary host shifts that occurred on various continents. Two major phylogenetic groups, bat-related RABV and dog-related RABV, experiencing markedly different evolutionary dynamics were identified...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27941941/potentiation-of-amitriptyline-anti-hyperalgesic-like-action-by-astroglial-connexin-43-inhibition-in-neuropathic-rats
#10
Tiffany Jeanson, Adeline Duchêne, Damien Richard, Sylvie Bourgoin, Christèle Picoli, Pascal Ezan, Franck Mouthon, Christian Giaume, Michel Hamon, Mathieu Charvériat
Antidepressants, prescribed as first line treatment of neuropathic pain, have a limited efficacy and poorly tolerated side effects. Because recent studies pointed out the implication of astroglial connexins (Cx) in both neuropathic pain and antidepressive treatment, we investigated whether their blockade by mefloquine could modulate the action of the tricyclic antidepressant amitriptyline. Using primary cultures, we found that both mefloquine and amitriptyline inhibited Cx43-containing gap junctions, and that the drug combination acted synergically...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27939314/17-th-century-variola-virus-reveals-the-recent-history-of-smallpox
#11
Ana T Duggan, Maria F Perdomo, Dario Piombino-Mascali, Stephanie Marciniak, Debi Poinar, Matthew V Emery, Jan P Buchmann, Sebastian Duchêne, Rimantas Jankauskas, Margaret Humphreys, G Brian Golding, John Southon, Alison Devault, Jean-Marie Rouillard, Jason W Sahl, Olivier Dutour, Klaus Hedman, Antti Sajantila, Geoffrey L Smith, Edward C Holmes, Hendrik N Poinar
Smallpox holds a unique position in the history of medicine. It was the first disease for which a vaccine was developed and remains the only human disease eradicated by vaccination. Although there have been claims of smallpox in Egypt, India, and China dating back millennia [1-4], the timescale of emergence of the causative agent, variola virus (VARV), and how it evolved in the context of increasingly widespread immunization, have proven controversial [4-9]. In particular, some molecular-clock-based studies have suggested that key events in VARV evolution only occurred during the last two centuries [4-6] and hence in apparent conflict with anecdotal historical reports, although it is difficult to distinguish smallpox from other pustular rashes by description alone...
December 19, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27939264/preconception-health-behaviours-a-scoping-review
#12
REVIEW
Kirsti I Toivonen, Kirsten A Oinonen, Katelyn M Duchene
Preconception health refers to the health of males and females at any point in time prior to a potential pregnancy. A goal of preconception health research is to use preventive behaviour and healthcare to optimize the health of future offspring that result from both planned and unplanned pregnancies. This paper briefly reviews evidence of the importance of various preconception health behaviours, and examines the extent to which specific preconception health behaviours have been included in recent studies of such knowledge, behaviours, and intentions...
December 6, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27916992/gene-editing-for-duchenne-muscular-dystrophy-using-the-crispr-cas9-technology-the-importance-of-fine-tuning-the-approach
#13
Jacques P Tremblay, Jean-Paul Iyombe-Engembe, Benjamin Duchêne, Dominique L Ouellet
No abstract text is available yet for this article.
November 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27899576/the-nuclear-and-organellar-trna-derived-rna-fragment-population-in-arabidopsis-thaliana-is-highly-dynamic
#14
Valérie Cognat, Geoffrey Morelle, Cyrille Megel, Stéphanie Lalande, Jean Molinier, Timothée Vincent, Ian Small, Anne-Marie Duchêne, Laurence Maréchal-Drouard
In the expanding repertoire of small noncoding RNAs (ncRNAs), tRNA-derived RNA fragments (tRFs) have been identified in all domains of life. Their existence in plants has been already proven but no detailed analysis has been performed. Here, short tRFs of 19-26 nucleotides were retrieved from Arabidopsis thaliana small RNA libraries obtained from various tissues, plants submitted to abiotic stress or fractions immunoprecipitated with ARGONAUTE 1 (AGO1). Large differences in the tRF populations of each extract were observed...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27886240/identification-of-er-000444793-a-cyclophilin-d-independent-inhibitor-of-mitochondrial-permeability-transition-using-a-high-throughput-screen-in-cryopreserved-mitochondria
#15
Thomas Briston, Sian Lewis, Mumta Koglin, Kavita Mistry, Yongchun Shen, Naomi Hartopp, Ryosuke Katsumata, Hironori Fukumoto, Michael R Duchen, Gyorgy Szabadkai, James M Staddon, Malcolm Roberts, Ben Powney
Growing evidence suggests persistent mitochondrial permeability transition pore (mPTP) opening is a key pathophysiological event in cell death underlying a variety of diseases. While it has long been clear the mPTP is a druggable target, current agents are limited by off-target effects and low therapeutic efficacy. Therefore identification and development of novel inhibitors is necessary. To rapidly screen large compound libraries for novel mPTP modulators, a method was exploited to cryopreserve large batches of functionally active mitochondria from cells and tissues...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870550/clinical-and-immunological-characteristics-of-autoimmune-addison-s-disease-a-nationwide-swedish-multicenter-study
#16
Frida Dalin, Gabriel Nordling Eriksson, Per Dahlqvist, Åsa Hallgren, Jeanette Wahlberg, Olov Ekwall, Stefan Söderberg, Johan Rönnelid, Per Olcén, Ola Winqvist, Sergiu-Bogdan Catrina, Berit Kriström, Maria Laudius, Magnus Isaksson, Maria Halldin Stenlid, Jan Gustafsson, Gennet Gebre-Medhin, Sigridur Björnsdottir, Annika Janson, Anna-Karin Åkerman, Jan Åman, Karel Duchen, Ragnhildur Bergthorsdottir, Gudmundur Johannsson, Emma Lindskog, Mona Landin-Olsson, Maria Elfving, Erik Waldenström, Anna-Lena Hulting, Olle Kämpe, Sophie Bensing
CONTEXT: Studies on clinical and immunological features of Autoimmune Addison's disease (AAD) are needed to understand the disease burden and increased mortality. OBJECTIVE: To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles and cardiovascular risk factors. DESIGN, SETTING AND PARTICIPANTS: Cross sectional, population-based study. 660 AAD patients were included utilizing the Swedish Addison Registry (SAR) 2008-2014...
November 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27869598/highly-divergent-dengue-virus-type-2-in-traveler-returning-from-borneo-to-australia
#17
Wenjun Liu, Paul Pickering, Sebastián Duchêne, Edward C Holmes, John G Aaskov
Dengue virus type 2 was isolated from a tourist who returned from Borneo to Australia. Phylogenetic analysis identified this virus as highly divergent and occupying a basal phylogenetic position relative to all known human and sylvatic dengue virus type 2 strains and the most divergent lineage not assigned to a new serotype.
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27863683/thirty-years-with-cyclodextrins
#18
Dominique Duchêne, Amélie Bochot
This paper reviews the work carried out on cyclodextrins during some thirty years at the Institut Galien Paris-Sud, UMR CNRS 8612, Université Paris-Sud. It represents the normal evolution of this domain of science and the numerous possibilities of cyclodextrins for being a tool adaptable to the most complex situations. The works which have been carried out concern: the investigation of general characteristics of cyclodextrins and derivatives, the preparation and evaluation of inclusion complexes, the use of cyclodextrins in the preparation of drug delivery systems, the various possibilities offered by cyclodextrins and their derivatives for nanoparticle preparation and finally the use of cyclodextrins for the preparation of biomaterials is evoked...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27854217/prevalence-and-genetic-profile-of-duchene-and-becker-muscular-dystrophy-in-puerto-rico
#19
Edwardo Ramos, José G Conde, Rafael Arias Berrios, Sherly Pardo, Omar Gómez, Manuel F Mas Rodríguez
BACKGROUND: Duchenne and Becker Muscular Dystrophy (DMD and BMD, respectively), are common forms of inherited muscle disease. Information regarding the epidemiology of these conditions, including genotype, is still sparse. OBJECTIVE: To establish the prevalence and genetic profile of DMD and BMD in Puerto Rico. METHODS: We collected data from medical records in all Muscular Dystrophy Association (MDA) clinics in Puerto Rico in order to estimate the prevalence of DMD and BMD and to describe the genotypic profile of these patients...
May 27, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27811056/cxcr4-identifies-transitional-bone-marrow-premonocytes-that-replenish-the-mature-monocyte-pool-for-peripheral-responses
#20
Shu Zhen Chong, Maximilien Evrard, Sapna Devi, Jinmiao Chen, Jyue Yuan Lim, Peter See, Yiru Zhang, José M Adrover, Bernett Lee, Leonard Tan, Jackson L Y Li, Ka Hang Liong, Cindy Phua, Akhila Balachander, Adrian Boey, David Liebl, Suet Mien Tan, Jerry K Y Chan, Karl Balabanian, John E Harris, Mariaelvy Bianchini, Christian Weber, Johan Duchene, Josephine Lum, Michael Poidinger, Qingfeng Chen, Laurent Rénia, Cheng-I Wang, Anis Larbi, Gwendalyn J Randolph, Wolfgang Weninger, Mark R Looney, Matthew F Krummel, Subhra K Biswas, Florent Ginhoux, Andrés Hidalgo, Françoise Bachelerie, Lai Guan Ng
It is well established that Ly6C(hi) monocytes develop from common monocyte progenitors (cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In our study, we found that BM Ly6C(hi) monocytes are not a homogenous population, as current data would suggest. Using computational analysis approaches to interpret multidimensional datasets, we demonstrate that BM Ly6C(hi) monocytes consist of two distinct subpopulations (CXCR4(hi) and CXCR4(lo) subpopulations) in both mice and humans...
October 17, 2016: Journal of Experimental Medicine
keyword
keyword
51161
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"