keyword
MENU ▼
Read by QxMD icon Read
search

Duchene

keyword
https://www.readbyqxmd.com/read/29132802/-prophylactic-radiotherapy-in-a-single-fraction-of-10gy-at-intervention-pleural-site-in-patient-with-malignant-pleural-mesothelioma-a-retrospective-monocentric-cohort-study
#1
H Carette, J-C Faivre, J Salleron, A-S Baumann, L Uwer, C Clément-Duchêne, J-M Vignaud, I Petit, J Siat, A Tiotiu, V Beckendorf
PURPOSE: Prophylactic radiotherapy to prevent procedure-tracts metastases from malignant pleural mesothelioma remains controversial and clinical practice varies. The purpose was to assess the efficacy of local radiotherapy in a single fraction of 10Gy in preventing malignant seeding at intervention pleural site in patients with malignant pleural mesothelioma. MATERIAL AND METHODS: This is a retrospective cohort study, including patients with histological confirmed malignant pleural mesothelioma treated by prophylactic irradiation to prevent interventional site metastases with a unique fraction of 10Gy with 6 to 18MeV, from January 1990 to December 2013 in the institut de cancérologie de Lorraine (Nancy, France)...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29117929/a-fully-automated-web-based-program-improves-lifestyle-habits-and-hba1c-in-patients-with-type-2-diabetes-and-abdominal-obesity-randomized-trial-of-patient-e-coaching-nutritional-support-the-anode-study
#2
Boris Hansel, Philippe Giral, Laetitia Gambotti, Alexandre Lafourcade, Gilbert Peres, Claude Filipecki, Diana Kadouch, Agnes Hartemann, Jean-Michel Oppert, Eric Bruckert, Michel Marre, Arnaud Bruneel, Emilie Duchene, Ronan Roussel
BACKGROUND: The prevalence of abdominal obesity and type 2 diabetes mellitus (T2DM) is a public health challenge. New solutions need to be developed to help patients implement lifestyle changes. OBJECTIVE: The objective of the study was to evaluate a fully automated Web-based intervention designed to help users improve their dietary habits and increase their physical activity. METHODS: The Accompagnement Nutritionnel de l'Obésité et du Diabète par E-coaching (ANODE) study was a 16-week, 1:1 parallel-arm, open-label randomized clinical trial...
November 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29067670/from-grna-identification-to-the-restoration-of-dystrophin-expression-a-dystrophin-gene-correction-strategy-for-duchenne-muscular-dystrophy-mutations-using-the-crispr-induced-deletion-method
#3
Benjamin Duchêne, Jean-Paul Iyombe-Engembe, Joël Rousseau, Jacques P Tremblay, Dominique L Ouellet
The discovery of the CRISPR-Cas9 system raises hope for the treatment of many genetic disorders. We describe here an approach based on the use of a pair of single guide RNAs to form a hybrid exon that does not only restore the dystrophin gene reading frame but also results in the production of a dystrophin protein with an adequate structure of the central rod-domain, with a correct spectrin-like repeat. The therapeutic approach described here involved DMD patient cells having a deletion of exons 51-53 of the DMD gene...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29044717/a-genome-scale-analysis-of-mrnas-targeting-to-plant-mitochondria-upstream-augs-in-5-utrs-reduce-mitochondrial-association
#4
Timothée Vincent, Audrey Vingadassalon, Elodie Ubrig, Kevin Azeredo, Ola Srour, Valérie Cognat, Stéfanie Graindorge, Thalia Salinas, Laurence Maréchal-Drouard, Anne-Marie Duchêne
Intracellular sorting of mRNAs is an essential process to regulate gene expression and protein localization. Most of mitochondrial proteins are nuclear-encoded and imported into mitochondria, through post-translational or co-translational processes. In the latter case, mRNAs are found enriched in the vicinity of mitochondria. A genome-scale analysis of mRNAs associated with mitochondria has been performed to determine plant cytosolic mRNAs targeted to the mitochondrial surface. Many messengers encoding mitochondrial proteins were found associated with mitochondria...
October 17, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29040651/the-chlamydomonas-mex1-mutant-shows-impaired-starch-mobilization-without-maltose-accumulation
#5
Justin Findinier, Hande Tunçay, Miriam Schulz-Raffelt, Philippe Deschamps, Corentin Spriet, Jean-Marie Lacroix, Thierry Duchêne, Nicolas Szydlowski, Yonghua Li-Beisson, Gilles Peltier, Christophe D'Hulst, Fabrice Wattebled, David Dauvillée
The MEX1 locus of Chlamydomonas reinhardtii was identified in a genetic screen as a factor that affects starch metabolism. Mutation of MEX1 causes a slow-down in the mobilization of storage polysaccharide. Cosegregation and functional complementation analyses were used to assess the involvement of the Mex1 protein in starch degradation. Heterologous expression experiments performed in Escherichia coli and Arabidopsis thaliana allowed us to test the capacity of the algal protein in maltose export. In contrast to the A...
October 5, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29029231/analysis-of-phylogenomic-tree-space-resolves-relationships-among-marsupial-families
#6
David A Duchêne, Jason G Bragg, Sebastián Duchêne, Linda E Neaves, Sally Potter, Craig Moritz, Rebecca N Johnson, Simon Y W Ho, Mark D B Eldridge
A fundamental challenge in resolving evolutionary relationships across the Tree of Life is to account for heterogeneity in the evolutionary signal across loci. Studies of marsupial mammals have demonstrated that this heterogeneity can be substantial, leaving considerable uncertainty in the evolutionary timescale and relationships within the group. Using simulations and a new phylogenomic data set comprising nucleotide sequences of 1550 loci from 18 of the 22 extant marsupial families, we demonstrate the power of a method for identifying clusters of loci that support different phylogenetic trees...
September 22, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28971018/a-new-version-of-the-grapevine-reference-genome-assembly-12x-v2-and-of-its-annotation-vcost-v3
#7
A Canaguier, J Grimplet, G Di Gaspero, S Scalabrin, E Duchêne, N Choisne, N Mohellibi, C Guichard, S Rombauts, I Le Clainche, A Bérard, A Chauveau, R Bounon, C Rustenholz, M Morgante, M-C Le Paslier, D Brunel, A-F Adam-Blondon
No abstract text is available yet for this article.
December 2017: Genomics Data
https://www.readbyqxmd.com/read/28962745/editorial-special-edition-of-international-journal-of-pharmaceutics-in-honor-of-professor-dominique-duch%C3%A3%C2%AAne
#8
EDITORIAL
Ruxandra Gref, Patrick Couvreur, Thorsteinn Loftsson
No abstract text is available yet for this article.
October 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28935262/identification-of-the-period-of-stability-in-a-balance-test-after-stepping-up-using-a-simplified-cumulative-sum
#9
Doha Safieddine, Aly Chkeir, Cyrille Herlem, Delphine Bera, Michèle Collart, Jean-Luc Novella, Moustapha Dramé, David J Hewson, Jacques Duchêne
Falls are a major cause of death in older people. One method used to predict falls is analysis of Centre of Pressure (CoP) displacement, which provides a measure of balance quality. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that calculates instantaneous values of vertical ground reaction force (Fz) as well as the CoP in both anteroposterior (AP) and mediolateral (ML) directions. The entire testing process needs to take no longer than 12 s to ensure subject compliance, making it vital that calculations related to balance are only calculated for the period when the subject is static...
November 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28874733/mitochondrial-permeability-transition-pore-sensitivity-to-opening-and-mechanistic-dependence-on-substrate-availability
#10
Thomas Briston, Malcolm Roberts, Sian Lewis, Ben Powney, James M Staddon, Gyorgy Szabadkai, Michael R Duchen
Mitochondrial Ca(2+) uptake has a key role in cellular Ca(2+) homeostasis. Excessive matrix Ca(2+) concentrations, especially when coincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conductance channel: the mitochondrial permeability transition pore (mPTP). mPTP opening has been implicated as a final cell death pathway in numerous diseases and therefore understanding conditions dictating mPTP opening is crucial for developing targeted therapies. Here, we have investigated the impact of mitochondrial metabolic state on the probability and consequences of mPTP opening...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869944/evidence-for-concerted-and-mosaic-brain-evolution-in-dragon-lizards
#11
Daniel Hoops, Marta Vidal-García, Jeremy F P Ullmann, Andrew L Janke, Timothy Stait-Gardner, David A Duchêne, William S Price, Martin J Whiting, J Scott Keogh
The brain plays a critical role in a wide variety of functions including behaviour, perception, motor control, and homeostatic maintenance. Each function can undergo different selective pressures over the course of evolution, and as selection acts on the outputs of brain function, it necessarily alters the structure of the brain. Two models have been proposed to explain the evolutionary patterns observed in brain morphology. The concerted brain evolution model posits that the brain evolves as a single unit and the evolution of different brain regions are coordinated...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28774861/multidisciplinary-tumor-board-decision-making-for%C3%A2-postoperative-radiotherapy-in-thymic-epithelial%C3%A2-tumors-insights-from-the-rythmic-prospective-cohort
#12
Clémence Basse, Sébastien Thureau, Suzanna Bota, Eric Dansin, Pascal-Alexandre Thomas, Eric Pichon, Hervé Lena, Carole Massabeau, Christelle Clément-Duchene, Gilbert Massard, Virginie Westeel, Xavier Quantin, Youssef Oulkhouir, Serge Danhier, Delphine Lerouge, Ronan Tanguy, François Thillays, Cécile Le Pechoux, Bernard Dubray, Luc Thiberville, Benjamin Besse, Nicolas Girard
INTRODUCTION: Thymic epithelial tumors (TETs) are rare intrathoracic malignancies for which surgery represents the mainstay of the treatment. Current practice for postoperative radiotherapy (PORT) is highly variable, and there is a lack of prospective, high level evidence. Réseau Tumeurs Thymiques et Cancer (RYTHMIC) is the nationwide network for TETs in France. Established in 2012, it prospectively collects data on all TET patients, for whom management is discussed at a national multidisciplinary tumor board (MTB)...
November 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28758282/phylogenetic-estimates-of-diversification-rate-are-affected-by-molecular-rate-variation
#13
D A Duchêne, X Hua, L Bromham
Molecular phylogenies are increasingly being used to investigate the patterns and mechanisms of macroevolution. In particular, node heights in a phylogeny can be used to detect changes in rates of diversification over time. Such analyses rest on the assumption that node heights in a phylogeny represent the timing of diversification events, which in turn rests on the assumption that evolutionary time can be accurately predicted from DNA sequence divergence. But there are many influences on the rate of molecular evolution, which might also influence node heights in molecular phylogenies, and thus affect estimates of diversification rate...
July 31, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28756003/-complementary-and-alternative-medicine-use-by-lung-cancer-patients
#14
R Rossanaly Vasram, M Zysman, B Ribeiro Baptista, C Ederle, P L Nguyen-Thi, C Clement-Duchene, Y Martinet
INTRODUCTION: Complementary and alternative medicine (CMA) use is frequent among cancer patients. Only few results are available about lung cancer patients. The aim of this study was to evaluate how often the CMA were used by lung cancer patients and to define the type of CMA used. METHODS: Every lung cancer patients with an ongoing chemotherapy in the respiratory department of the University Hospital of Nancy were approached between November 2014 to July 2015...
July 26, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28747090/retrospective-evaluation-of-milk-production-and-culling-risk-following-either-surgical-toggle-pin-suture-or-conservative-treatment-of-left-displaced-abomasum-in-chilean-dairy-cows
#15
P Melendez, C Romero, P Pithua, M P Marin, P Pinedo, M Duchens
AIMS To describe milk yield and culling risk in cows diagnosed with left displacement of abomasum (LDA) treated either conservatively, by right flank pyloric omentopexy, or rolling and toggling, compared with normal herdmates from four Chilean dairy herds. METHODS Historical records were obtained from four commercial dairy farms located in Central Chile for cows with a history of LDA between 2010 and 2012, and healthy herdmates. Cows with LDA were categorised into three groups: cows treated with right omentopexy (ST, n=58), cows treated by toggle suturing (TT, n=15) and cows treated conservatively (CT, n=56)...
August 13, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28726526/integrated-care-coordination-by-an-interprofessional-team-reduces-emergency-department-visits-and-hospitalisations-at-an-academic-health-centre
#16
Anne H Gaglioti, Patrick Barlow, Kate DuChene Thoma, George R Bergus
People with chronic behavioural and physical health conditions have higher healthcare costs and mortality rates than patients with chronic physical conditions alone. As a result, there has been promotion of integrated care for this group. It is important to train primary care residents to practice in integrated models of care with interprofessional teams and to evaluate the effectiveness of integrated care models to promote high-quality care for this at-risk group. We implemented an integrated, interprofessional care management programme for adults with chronic mental and physical health needs as part of a curriculum for family medicine and family medicine psychiatry residents...
July 20, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28721572/i-fabp-is-a-novel-marker-for-the-detection-of-intestinal-injury-in-severely-injured-trauma-patients
#17
M Voth, M Duchene, B Auner, T Lustenberger, B Relja, I Marzi
BACKGROUND: Intestinal injury is a rare injury in multiply traumatized patients, and its diagnosis remains difficult. Delayed diagnosis of an intestinal injury increases the risk of sepsis, multiple organ failure and mortality. The intestinal fatty acid-binding protein (I-FABP) is solely expressed in the intestine and is released extracellulary after tissue damage. This study evaluates the validity of I-FABP as an early biomarker to detect an abdominal injury and particularly an injury to the intestine...
December 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28711413/-hypofractionated-stereotactic-radiotherapy-for-brain-metastasis-benefit-of-additional-whole-brain-radiotherapy
#18
P Royer, J Salleron, G Vogin, L Taillandier, C Clément-Duchêne, O Klein, J-C Faivre, D Peiffert, V Bernier
PURPOSE: To study overall survival, risk of neurological death, local recurrence and development of new brain metastasis in patients treated for brain oligometastases with hypofractionated stereotactic radiotherapy with CyberKnife(®), according to the association or not with an additional whole brain irradiation. PATIENTS AND METHODS: Institutional retrospective study of 102 patients treated for one to three brain metastasis: 76 with exclusive hypofractionated stereotactic radiotherapy and 26 with hypofractionated stereotactic radiotherapy and whole brain irradiation...
July 12, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28663258/ly6c-high-monocytes-oscillate-in-the-heart-during-homeostasis-and-after-myocardial-infarction-brief-report
#19
Maximilian J Schloss, Michael Hilby, Katrin Nitz, Raquel Guillamat Prats, Bartolo Ferraro, Giovanna Leoni, Oliver Soehnlein, Thorsten Kessler, Wenyan He, Bruno Luckow, Michael Horckmans, Christian Weber, Johan Duchene, Sabine Steffens
OBJECTIVE: Circadian regulation of neutrophil homeostasis affects myocardial infarction (MI) healing. It is unknown whether diurnal variations of monocyte counts exist in the heart and whether this affects their cardiac infiltration in response to MI. APPROACH AND RESULTS: Murine blood and organs were harvested at distinct times of day and analyzed by flow cytometry. Ly6C(high) monocyte surface expression levels of chemokine receptors (CCR) were ≈2-fold higher at the beginning of the active phase, Zeitgeber Time (ZT) 13 compared with ZT5...
September 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28638507/the-impact-of-using-mean-versus-mode-when-assessing-resident-competency
#20
Patrick B Barlow, Kate DuChene Thoma, Kristi J Ferguson
BACKGROUND: The Accreditation Council for Graduate Medical Education Milestone Project was implemented in 2014 to standardize assessments and progression of residents. While it is recommended that milestones not be used as tools for direct assessments of resident competency, many programs have used or adapted milestone tools for this purpose. OBJECTIVE: We sought to explore use of the most frequent milestone level at which a resident was evaluated (ie, the mode), and compared this to the standard practice of using the arithmetic mean for summarizing performance...
June 2017: Journal of Graduate Medical Education
keyword
keyword
51161
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"