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https://www.readbyqxmd.com/read/29791496/pbp2b-plays-a-key-role-in-both-peripheral-growth-and-septum-positioning-in-lactococcus-lactis
#1
Blandine David, Marie-Clémence Duchêne, Gabrielle Laurie Haustenne, Daniel Pérez-Núñez, Marie-Pierre Chapot-Chartier, Xavier De Bolle, Eric Guédon, Pascal Hols, Bernard Hallet
Lactococcus lactis is an ovoid bacterium that forms filaments during planktonic and biofilm lifestyles by uncoupling cell division from cell elongation. In this work, we investigate the role of the leading peptidoglycan synthase PBP2b that is dedicated to cell elongation in ovococci. We show that the localization of a fluorescent derivative of PBP2b remains associated to the septal region and superimposed with structural changes of FtsZ during both vegetative growth and filamentation indicating that PBP2b remains intimately associated to the division machinery during the whole cell cycle...
2018: PloS One
https://www.readbyqxmd.com/read/29788113/differences-in-performance-among-test-statistics-for-assessing-phylogenomic-model-adequacy
#2
David A Duchêne, Sebastian Duchêne, Simon Y W Ho
Statistical phylogenetic analyses of genomic data depend on models of nucleotide or amino acid substitution. The adequacy of these substitution models can be assessed using a number of test statistics, allowing the model to be rejected when it is found to provide a poor description of the evolutionary process. A potentially valuable use of model-adequacy test statistics is to identify when data sets are likely to produce unreliable phylogenetic estimates, but their differences in performance are rarely explored...
May 18, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29769015/a-comparison-of-methods-for-estimating-substitution-rates-from-ancient-dna-sequence-data
#3
K Jun Tong, David A Duchêne, Sebastián Duchêne, Jemma L Geoghegan, Simon Y W Ho
BACKGROUND: Phylogenetic analysis of DNA from modern and ancient samples allows the reconstruction of important demographic and evolutionary processes. A critical component of these analyses is the estimation of evolutionary rates, which can be calibrated using information about the ages of the samples. However, the reliability of these rate estimates can be negatively affected by among-lineage rate variation and non-random sampling. Using a simulation study, we compared the performance of three phylogenetic methods for inferring evolutionary rates from time-structured data sets: regression of root-to-tip distances, least-squares dating, and Bayesian inference...
May 16, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29734234/two-year-longitudinal-changes-in-lower-limb-strength-and-its-relation-to-loss-in-function-in-a-large-cohort-of-patients-with-duchenne-muscular-dystrophy
#4
Abhinandan Batra, Ann Harrington, Donovan J Lott, Rebecca Willcocks, Claudia Senesac, William McGehee, Dandan Xu, Sunita Mathur, Michael J Daniels, William D Rooney, Sean C Forbes, William Triplett, Jasjit K Deol, Ishu Arpan, Roxanne Bendixen, Richard Finkel, Erika Finanger, Gihan Tennekoon, Barry Byrne, Barry Russman, Lee H Sweeney, Glenn Walter, Krista Vandenborne
OBJECTIVE: The main objective of this study were to examine the effect of disease on strength in two functionally important lower limb muscles over a period of two-years in children with Duchene Muscular Dystrophy (DMD). DESIGN: Seventy-Seven DMD children participated in this study. Plantar flexors (PF), knee extensors (KE) strength and performance on timed tests (Six-min walk, 4-stairs, 10m-walk, supine-up) was assessed yearly over two-years. Multivariate normal regression was used to assess changes in strength over time in the DMD group...
May 2, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29705868/new-hope-for-treatment-of-duchene-dystrophy-by-employing-dystrophin-expressing-chimeric-cells-studies-published-in-stem-cell-reviews-and-reports
#5
EDITORIAL
Mariusz Z Ratajczak
No abstract text is available yet for this article.
June 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29704626/understanding-dengue-virus-evolution-to-support-epidemic-surveillance-and-counter-measure-development
#6
REVIEW
S Pollett, M C Melendrez, I Maljkovic Berry, S Duchêne, H Salje, Cummings Dat, R G Jarman
Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae.aegypti and Ae.albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods...
April 25, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29701772/inositol-trisphosphate-receptor-mediated-ca2-signalling-stimulates-mitochondrial-function-and-gene-expression-in-core-myopathy-patients
#7
Matteo Suman, Jenny A Sharpe, Robert B Bentham, Vassilios N Kotiadis, Michela Menegollo, Viviana Pignataro, Jordi Molgó, Francesco Muntoni, Michael R Duchen, Elena Pegoraro, Gyorgy Szabadkai
Core myopathies are a group of childhood muscle disorders caused by mutations of the ryanodine receptor (RyR1), the Ca2+ release channel of the sarcoplasmic reticulum. These mutations have previously been associated with elevated inositol trisphosphate receptor (IP3R) levels in skeletal muscle myotubes derived from patients. However, the functional relevance and the relationship of IP3R mediated Ca2+ signalling with the pathophysiology of the disease is unclear. It has also been suggested that mitochondrial dysfunction underlies the development of central and diffuse multi-mini-cores, devoid of mitochondrial activity, which is a key pathological consequence of RyR1 mutations...
April 25, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29692797/combined-therapies-for-duchenne-muscular-dystrophy-to-optimize-treatment-efficacy
#8
REVIEW
Gonzalo Cordova, Elisa Negroni, Claudio Cabello-Verrugio, Vincent Mouly, Capucine Trollet
Duchene Muscular Dystrophy (DMD) is the most frequent muscular dystrophy and one of the most severe due to the absence of the dystrophin protein. Typical pathological features include muscle weakness, muscle wasting, degeneration, and inflammation. At advanced stages DMD muscles present exacerbated extracellular matrix and fat accumulation. Recent progress in therapeutic approaches has allowed new strategies to be investigated, including pharmacological, gene-based and cell-based therapies. Gene and cell-based therapies are still limited by poor targeting and low efficiency in fibrotic dystrophic muscle, therefore it is increasingly evident that future treatments will have to include "combined therapies" to reach maximal efficiency...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29684021/laboratory-and-molecular-surveillance-of-paediatric-typhoidal-salmonella-in-nepal-antimicrobial-resistance-and-implications-for-vaccine-policy
#9
Carl D Britto, Zoe A Dyson, Sebastian Duchene, Michael J Carter, Meeru Gurung, Dominic F Kelly, David R Murdoch, Imran Ansari, Stephen Thorson, Shrijana Shrestha, Neelam Adhikari, Gordon Dougan, Kathryn E Holt, Andrew J Pollard
BACKGROUND: Children are substantially affected by enteric fever in most settings with a high burden of the disease, including Nepal. However pathogen population structure and transmission dynamics are poorly delineated in young children, the proposed target group for immunization programs. Here we present whole genome sequencing and antimicrobial susceptibility data on 198 S. Typhi and 66 S. Paratyphi A isolated from children aged 2 months to 15 years of age during blood culture surveillance at Patan Hospital, Nepal, 2008-2016...
April 23, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29669293/three-dimensional-human-ipsc-derived-artificial-skeletal-muscles-model-muscular-dystrophies-and-enable-multilineage-tissue-engineering
#10
Sara Martina Maffioletti, Shilpita Sarcar, Alexander B H Henderson, Ingra Mannhardt, Luca Pinton, Louise Anne Moyle, Heather Steele-Stallard, Ornella Cappellari, Kim E Wells, Giulia Ferrari, Jamie S Mitchell, Giulia E Tyzack, Vassilios N Kotiadis, Moustafa Khedr, Martina Ragazzi, Weixin Wang, Michael R Duchen, Rickie Patani, Peter S Zammit, Dominic J Wells, Thomas Eschenhagen, Francesco Saverio Tedesco
Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including induced pluripotent stem cells (iPSCs) from patients with Duchenne, limb-girdle, and congenital muscular dystrophies. 3D skeletal myogenic differentiation of pluripotent cells was induced within hydrogels under tension to provide myofiber alignment. Artificial muscles recapitulated characteristics of human skeletal muscle tissue and could be implanted into immunodeficient mice...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29656082/ultra-high-performance-supercritical-fluid-chromatography-hyphenated-to-atmospheric-pressure-chemical-ionization-high-resolution-mass-spectrometry-for-the-characterization-of-fast-pyrolysis-bio-oils
#11
Julien Crepier, Agnès Le Masle, Nadège Charon, Florian Albrieux, Pascal Duchene, Sabine Heinisch
Extensive characterization of complex mixtures requires the combination of powerful analytical techniques. A Supercritical Fluid Chromatography (SFC) method was previously developed, for the specific case of fast pyrolysis bio oils, as an alternative to gas chromatography (GC and GC × GC) or liquid chromatography (LC and LC × LC), both separation methods being generally used prior to mass spectrometry (MS) for the characterization of such complex matrices. In this study we investigated the potential of SFC hyphenated to high resolution mass spectrometry (SFC-HRMS) for this characterization using Negative ion Atmospheric Pressure Chemical ionization ((-)APCI) for the ionization source...
April 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29600052/a-pooled-analysis-of-advanced-nonsquamous-non-small-cell-lung-cancer-patients-with-stable-treated-brain-metastases-in-two-phase-ii-trials-receiving-bevacizumab-and-pemetrexed-as-second-line-therapy
#12
Matthew A Gubens, Jody C Chuang, Wallace Akerley, Corey J Langer, Christelle Clément-Duchêne, Melanie San Pedro-Salcedo, A Dimitrios Colevas, Konstantin Dragnev, Mark A Socinski, Heather A Wakelee
Background: Brain metastases are a common complication of advanced non-small cell lung cancer (NSCLC). Patients with brain metastases were excluded from the registration trials of bevacizumab that showed a survival benefit with the use of angiogenesis inhibition. Methods: In this study, we pooled data from two separate trials designed to evaluate the risk of central nervous system (CNS) hemorrhage in patients with stable treated brain metastases to look specifically at both the safety and efficacy of bevacizumab and pemetrexed when used as second-line treatment in NSCLC patients with stable treated brain metastases...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29580181/decellularised-cartilage-directs-chondrogenic-differentiation-creation-of-a-fracture-callus-mimetic
#13
Wollis Jude Vas, Mittal Shah, Thomas Stephen Blacker, Michael Roland Duchen, Paul Sibbons, Scott John Roberts
Complications that arise from impaired fracture healing have considerable socioeconomic implications. Current research in the field of bone tissue engineering predominantly aims to mimic the mature bone tissue microenvironment. This approach, however, may produce implants that are intrinsically unresponsive to the cues present during the initiation of fracture repair. As such, this study describes the development of decellularised xenogeneic hyaline cartilage matrix in an attempt to mimic the initial reparative phase of fracture repair...
March 27, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29522350/hot-hole-collection-and-photoelectrochemical-co-2-reduction-with-plasmonic-au-p-gan-photocathodes
#14
Joseph S DuChene, Giulia Tagliabue, Alex J Welch, Wen-Hui Cheng, Harry A Atwater
Harvesting nonequilibrium hot carriers from plasmonic-metal nanostructures offers unique opportunities for driving photochemical reactions at the nanoscale. Despite numerous examples of hot electron-driven processes, the realization of plasmonic systems capable of harvesting hot holes from metal nanostructures has eluded the nascent field of plasmonic photocatalysis. Here, we fabricate gold/p-type gallium nitride (Au/p-GaN) Schottky junctions tailored for photoelectrochemical studies of plasmon-induced hot-hole capture and conversion...
April 11, 2018: Nano Letters
https://www.readbyqxmd.com/read/29511572/estimating-evolutionary-rates-in-giant-viruses-using-ancient-genomes
#15
Sebastián Duchêne, Edward C Holmes
Pithovirus sibericum is a giant (610 Kpb) double-stranded DNA virus discovered in a purportedly 30,000-year-old permafrost sample. A closely related virus, Pithovirus massiliensis , was recently isolated from a sewer in southern France. An initial comparison of these two virus genomes assumed that P. sibericum was directly ancestral to P. massiliensis and gave a maximum evolutionary rate of 2.60 × 10-5 nucleotide substitutions per site per year (subs/site/year). If correct, this would make pithoviruses among the fastest-evolving DNA viruses, with rates close to those seen in some RNA viruses...
January 2018: Virus Evolution
https://www.readbyqxmd.com/read/29509900/a-genetic-modifier-suggests-that-endurance-exercise-exacerbates-huntington-s-disease
#16
Silvia Corrochano, Gonzalo Blanco, Debbie Williams, Jessica Wettstein, Michelle Simon, Saumya Kumar, Lee Moir, Thomas Agnew, Michelle Stewart, Allison Landman, Vassilios N Kotiadis, Michael R Duchen, Henning Wackerhage, David C Rubinsztein, Steve D M Brown, Abraham Acevedo-Arozena
Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine tract explain up to 70% of the age-at-onset variance, with the rest of the variance attributed to genetic and environmental modifiers. To identify novel disease modifiers, we performed an unbiased mutagenesis screen on an HD mouse model, identifying a mutation in the skeletal muscle voltage-gated sodium channel (Scn4a, termed 'draggen' mutation) as a novel disease enhancer...
May 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29486771/mitochondrial-damage-and-plugging-of-transport-selectively-in-myelinated-small-diameter-axons-are-major-early-events-in-peripheral-neuroinflammation
#17
Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A Gregson, Michael R Duchen, Kenneth J Smith
BACKGROUND: Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known. METHODS: We used in vivo confocal microscopy to compare the effects of inflammation in experimental autoimmune neuritis (EAN), a model of Guillain-Barré syndrome (GBS), on mitochondrial function and transport in large- and small-diameter axons. We have compared mitochondrial function and transport in vivo in (i) healthy axons, (ii) axons affected by experimental autoimmune neuritis, and (iii) axons in which mitochondria were focally damaged by laser induced photo-toxicity...
February 27, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29481585/phylomad-efficient-assessment-of-phylogenomic-model-adequacy
#18
David A Duchêne, Sebastian Duchêne, Simon Y W Ho
Summary: Statistical phylogenetic inference plays an important role in evolutionary biology. The accuracy of phylogenetic methods relies on having suitable models of the evolutionary process. Various tools allow comparisons of candidate phylogenetic models, but assessing the absolute performance of models remains a considerable challenge. We introduce PhyloMAd, a user-friendly application for assessing the adequacy of commonly used models of nucleotide substitution and among-lineage rate variation...
February 21, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29480363/ultrasound-plus-low-level-laser-therapy-for-knee-osteoarthritis-rehabilitation-a-randomized-placebo-controlled-trial
#19
Fernanda Rossi Paolillo, Alessandra Rossi Paolillo, Jessica Patrícia João, Daniele Frascá, Marcelo Duchêne, Herbert Alexandre João, Vanderlei Salvador Bagnato
This study evaluated the synergistic effects of ultrasound (US) and low-level laser therapy (LLLT) with or without therapeutic exercises (TE) in women with knee osteoarthritis. Forty-two Caucasian women with knee osteoarthritis were allocated into three groups: (1) the placebo group who did not perform TE, but the prototype without emitting light or ultrasonic waves was applied, (2) the US + LLLT group in which only the prototype was applied and (3) the TE + US + LLLT group that performed TE before the prototype was applied...
May 2018: Rheumatology International
https://www.readbyqxmd.com/read/29450750/survival-impact-of-stations-of-pathological-lymph-nodes-in-n2-non-small-cell-lung-cancer-in-a-french-hospital
#20
Christelle Clément-Duchêne, Amandine Luc, Jean-Matthieu Casse, Jean-Michel Vignaud, Stéphanie Lacomme, Valentine Anne, Joëlle Siat, Olivier Ménard, Yves Martinet
BACKGROUND: The prognosis of lung cancer remains poor; only 20% of patients can undergo surgery. N2 non-small cell lung cancer (NSCLC) is a heterogeneous disease. We conducted a retrospective study to analyze the impact of N2 location on survival. METHODS: This study included 342 NSCLC with N2 involvement between 1988 and 2014. Patient-related data were collected through the CRB biobank and included demographic, therapeutic, and survival data. Survival was analyzed according to Kaplan-Maier method...
May 2018: Annals of Surgical Oncology
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