Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Zoë E Havlena, Louise D Hose, Harvey R DuChene, Gretchen M Baker, J Douglas Powell, Amanda L Labrado, Benjamin Brunner, Daniel S Jones
Lehman Caves is an extensively decorated high desert cave that represents one of the main tourist attractions in Great Basin National Park, Nevada. Although traditionally considered a water table cave, recent studies identified abundant speleogenetic features consistent with a hypogenic and, potentially, sulfuric acid origin. Here, we characterized white mineral deposits in the Gypsum Annex (GA) passage to determine whether these secondary deposits represent biogenic minerals formed during sulfuric acid corrosion and explored microbial communities associated with these and other mineral deposits throughout the cave...
2024: Geobiology
#2
JOURNAL ARTICLE
Dylan Duchen, Steven J Clipman, Candelaria Vergara, Chloe L Thio, David L Thomas, Priya Duggal, Genevieve L Wojcik
Nearly 300 million individuals live with chronic hepatitis B virus (HBV) infection (CHB), for which no curative therapy is available. As viral diversity is associated with pathogenesis and immunological control of infection, improved methods to characterize this diversity could aid drug development efforts. Conventionally, viral sequencing data are mapped/aligned to a reference genome, and only the aligned sequences are retained for analysis. Thus, reference selection is critical, yet selecting the most representative reference a priori remains difficult...
2024: PloS One
#3
Radha Nangliya, Anam R Sasun, Snehal Samal
This case report provides insights into the physiotherapy management of a 12-year-old male with Duchenne muscular dystrophy (DMD). DMD is a devastating genetic disorder characterized by progressive muscle degeneration and weakness. Skeletal muscle degeneration is induced by a genetic disorder. It is a common X-linked condition that causes hypertrophy of the calves and proximal muscular weakness in children. It frequently results in early mortality, wheelchair confinement, and delays in motor development...
March 2024: Curēus
#4
JOURNAL ARTICLE
Chuanjing Hou, Can Liu, Zhi Li, Duchen Zhong
The accurate positioning and swing suppression of tower cranes remain open problems, especially when considering unknown payload masses, frictions and wind disturbances, making the controller design more challenging. Therefore, considering the factors, without linearization to 5-DOF tower crane dynamics, an improved non-singular fast terminal sliding mode control (INFTSMC) scheme is proposed, which can drive the trolley, jib and cable to the desired positions accurately within finite time while suppressing payload swings effectively under the unknown payload masses, frictions and wind disturbances...
April 5, 2024: ISA Transactions
#5
JOURNAL ARTICLE
Josefin Stiller, Shaohong Feng, Al-Aabid Chowdhury, Iker Rivas-González, David A Duchêne, Qi Fang, Yuan Deng, Alexey Kozlov, Alexandros Stamatakis, Santiago Claramunt, Jacqueline M T Nguyen, Simon Y W Ho, Brant C Faircloth, Julia Haag, Peter Houde, Joel Cracraft, Metin Balaban, Uyen Mai, Guangji Chen, Rongsheng Gao, Chengran Zhou, Yulong Xie, Zijian Huang, Zhen Cao, Zhi Yan, Huw A Ogilvie, Luay Nakhleh, Bent Lindow, Benoit Morel, Jon Fjeldså, Peter A Hosner, Rute R da Fonseca, Bent Petersen, Joseph A Tobias, Tamás Székely, Jonathan David Kennedy, Andrew Hart Reeve, Andras Liker, Martin Stervander, Agostinho Antunes, Dieter Thomas Tietze, Mads Bertelsen, Fumin Lei, Carsten Rahbek, Gary R Graves, Mikkel H Schierup, Tandy Warnow, Edward L Braun, M Thomas P Gilbert, Erich D Jarvis, Siavash Mirarab, Guojie Zhang
Despite tremendous efforts in the past decades, relationships among main avian lineages remain heavily debated without a clear resolution. Discrepancies have been attributed to diversity of species sampled, phylogenetic method, and the choice of genomic regions 1-3 . Here, we address these issues by analyzing genomes of 363 bird species 4 (218 taxonomic families, 92% of total). Using intergenic regions and coalescent methods, we present a well-supported tree but also a remarkable degree of discordance. The tree confirms that Neoaves experienced rapid radiation at or near the Cretaceous-Paleogene (K-Pg) boundary...
April 1, 2024: Nature
#6
JOURNAL ARTICLE
Léa Boulnois, Margot Robles, Nada Maaziz, Bernard Aral, Martin Gauthier, Francis Duchene, Marie-Amélie Goujart, Betty Gardie, François Girodon
Not available.
March 28, 2024: Haematologica
#7
JOURNAL ARTICLE
Manish Suneja, Kate DuChene Hanrahan, Clarence Kreiter, Jane Rowat
PURPOSE: The objective structured clinical examination (OSCE) assesses clinical competence in health sciences education. There is little research regarding the reliability and validity of using an OSCE during the transition from undergraduate to graduate medical education. The goal of this study was to measure the reliability of a unique 2-rater entrustable professional activity (EPA)-based OSCE format for transition to internship using generalizability theory for estimating reliability...
March 26, 2024: Academic Medicine
#8
JOURNAL ARTICLE
David A Duchêne, Sebastián Duchêne, Josefin Stiller, Rasmus Heller, Simon Y W Ho
Phylogenomic data provide valuable opportunities for studying evolutionary rates and timescales. These analyses require theoretical and statistical tools based on molecular clocks. We present ClockstaRX, a flexible platform for exploring and testing evolutionary rate signals in phylogenomic data. Here, information about evolutionary rates in branches across gene trees is placed in Euclidean space, allowing data transformation, visualization, and hypothesis testing. ClockstaRX implements formal tests for identifying groups of loci and branches that make a large contribution to patterns of rate variation...
March 25, 2024: Genome Biology and Evolution
#9
JOURNAL ARTICLE
Laura Chen, Rebecca M Munday, Rashidul Haque, Dylan Duchen, Uma Nayak, Poonum Korpe, Alexander J Mentzer, Beth D Kirkpatrick, Genevieve L Wojcik, William A Petri, Priya Duggal
BACKGROUND: Astroviral infections commonly cause acute nonbacterial gastroenteritis in children globally. However, these infections often go undiagnosed outside of research settings. There is no treatment available for astrovirus, and Astroviridae strain diversity presents a challenge to potential vaccine development. METHODS: To address our hypothesis that host genetic risk factors are associated with astrovirus disease susceptibility, we performed a genome-wide association study of astrovirus infection in the first year of life from children enrolled in 2 Bangladeshi birth cohorts...
March 2024: Open Forum Infectious Diseases
#10
JOURNAL ARTICLE
Laura Dimnet, Thalia Salinas-Giegé, Sara Pullara, Lucas Moyet, Chloé Genevey, Marcel Kuntz, Anne-Marie Duchêne, Norbert Rolland
Excluding the few dozen proteins encoded by the chloroplast and mitochondrial genomes, the majority of plant cell proteins are synthesized by cytosolic ribosomes. Most of these nuclear-encoded proteins are then targeted to specific cell compartments thanks to localization signals present in their amino acid sequence. These signals can be specific amino acid sequences known as transit peptides, or post-translational modifications, ability to interact with specific proteins or other more complex regulatory processes...
2024: Methods in Molecular Biology
#11
JOURNAL ARTICLE
Alexandre Berger, Elise Beckers, Vincent Joris, Gaëtan Duchêne, Venethia Danthine, Nicolas Delinte, Inci Cakiroglu, Siya Sherif, Enrique Ignacio Germany Morrison, Andres Torres Sánchez, Benoit Macq, Laurence Dricot, Gilles Vandewalle, Riëm El Tahry
The locus coeruleus-norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This system is known to prevent seizure development and induce long-term plastic changes, particularly with the release of norepinephrine in the hippocampus. However, the requisites to become responder to the therapy and the mechanisms of action are still under investigation. Using MRI, we assessed the structural and functional characteristics of the locus coeruleus and microstructural properties of locus coeruleus-hippocampus white matter tracts in patients with drug-resistant epilepsy responding or not to the therapy...
2024: Frontiers in Neuroscience
#12
JOURNAL ARTICLE
Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, Onnik Agbulut, Arnaud Ferry
Mechanical overloading (OVL) resulting from the ablation of muscle agonists, a supra-physiological model of resistance training, reduces skeletal muscle fragility, i.e. the immediate maximal force drop following lengthening contractions, and increases maximal force production, in mdx mice, a murine model of Duchene muscular dystrophy (DMD). Here, we further analyzed these beneficial effects of OVL by determining whether they were blocked by cyclosporin, an inhibitor of the calcineurin pathway, and whether there were also observed in the D2-mdx mice, a more severe murine DMD model...
2024: PloS One
#13
JOURNAL ARTICLE
Mostafa S Ali, Marwa S Saleh
OBJECTIVES: Progressive proximal muscle weakening in children with Duchenne muscular dystrophy (DMD) impairs postural adjustments by impairing motor function and preventing ambulation. During daily activities, for gait and dynamic balance, certain postural modifications are required. The objective was to compare the impact of trunk-oriented exercises versus whole-body vibration on abdominal muscle thickness and balance in children with DMD. METHODS: Participants in this study were 30 boys with DMD, aged 6 to 10 years old...
March 1, 2024: Journal of Musculoskeletal & Neuronal Interactions
#14
JOURNAL ARTICLE
Anna Nagode, Jorick Vanbeselaere, Michael Duchêne
The parasite Entamoeba histolytica is the cause of amoebic dysentery and liver abscess in humans. On the protozoan cell surface, a variety of glycosylated molecules are involved in the interaction with the environment, such as attachment to the colonic mucus. One of these molecules is the lipopeptidophosphoglycan (LPPG), a complex surface component with antigenic properties. Its structure is only partly known, it is a glycosylphosphatidylinositol (GPI)-linked glycoprotein with a large amount of O-glycosylation...
February 21, 2024: Parasitology Research
#15
Pramod Bhattarai, Monika Karki
Duchene muscular dystrophy (DMD) is a genetic disorder primarily affecting males. It is characterized by progressive muscle tissue degeneration. Patients with DMD are at an increased risk of respiratory infections, including coronavirus disease 20019 (COVID-19), due to weakened respiratory muscles. We present a case of a young male with DMD who experienced recurrent pneumothorax 10 months after recovering from a COVID-19 infection. The patient required prompt medical intervention, including a chest tube, multiple surgeries, and mechanical pleurodesis...
January 2024: Curēus
#16
JOURNAL ARTICLE
Leo A Featherstone, Andrew Rambaut, Sebastian Duchene, Wytamma Wirth
Molecular sequence data from rapidly evolving organisms are often sampled at different points in time. Sampling times can then be used for molecular clock calibration. The root-to-tip (RTT) regression is an essential tool to assess the degree to which the data behave in a clock-like fashion. Here, we introduce Clockor2, a client-side web application for conducting RTT regression. Clockor2 allows users to quickly fit local and global molecular clocks, thus handling the increasing complexity of genomic datasets that sample beyond the assumption of homogeneous host populations...
February 17, 2024: Systematic Biology
#17
REVIEW
Megan E Vasterling, Rebecca J Maitski, Brice A Davis, Julie E Barnes, Rucha A Kelkar, Rachel J Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D Kaye, Giustino Varrassi
AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder characterized by a mutation in the DMD gene. Symptoms include progressive muscle weakness, respiratory and cardiac complications, and premature death. Casimersen targets a specific mutation in the DMD gene that results in the absence of dystrophin protein, a key structural component of muscle fibers. While there is currently no cure for DMD, exon-skipping therapy works by restoring the reading frame of the mutated gene, allowing the production of a partially functional dystrophin protein...
December 2023: Curēus
#18
JOURNAL ARTICLE
Alitha Edison, Anja Michelbach, Dominique Sowade, Hanna Kertzel, Luise Schmidt, Martin Schäfer, Maximillian Lysander, Ralf Nauen, Pablo Duchen, Shuqing Xu
Agricultural pests can develop behavioral resistance to insecticides by choosing to feed or oviposit on insecticide-free hosts. As young larvae have relatively low mobility, oviposition preferences from female adults may play a critical role in shaping the evolutionary trajectory of pest populations. While oviposition avoidance of insecticide-treated hosts was found in different agriculture pests, it remains unclear whether female adults actively choose to occupy insecticide-free hosts. To address this question, we investigated feeding and oviposition preferences between imidacloprid-treated and imidacloprid-free plants in the Colorado potato beetle, Leptinotarsa decemlineata Say, a major potato pest...
January 28, 2024: Insect Science
#19
REVIEW
Plant-soil synchrony in nutrient cycles: Learning from ecosystems to design sustainable agrosystems.
Sébastien Fontaine, Luc Abbadie, Michaël Aubert, Sébastien Barot, Juliette M G Bloor, Delphine Derrien, Olivier Duchene, Nicolas Gross, Ludovic Henneron, Xavier Le Roux, Nicolas Loeuille, Jennifer Michel, Sylvie Recous, Daniel Wipf, Gaël Alvarez
Redesigning agrosystems to include more ecological regulations can help feed a growing human population, preserve soils for future productivity, limit dependency on synthetic fertilizers, and reduce agriculture contribution to global changes such as eutrophication and warming. However, guidelines for redesigning cropping systems from natural systems to make them more sustainable remain limited. Synthetizing the knowledge on biogeochemical cycles in natural ecosystems, we outline four ecological systems that synchronize the supply of soluble nutrients by soil biota with the fluctuating nutrient demand of plants...
January 2024: Global Change Biology
#20
Vahid Omarmeli, Kai-Uwe Lewandrovski, Marjan Assefi, Hanieh Faizmahdavi, Alireza Sharafshah, Nasrin Mansouri
BACKGROUND: Duchene Muscular Disorder (DMD) is a severe X-linked recessive neuromuscular disease. Previous reports predicted that one-third of cases with a fatal X-linked recessive disease will be caused by a novel mutation, and the mutation rate for DMD seems to be higher in males. OBJECTIVE: A novel mutation in the DMD gene DMD (NM_004006.3):c.92A>G (p.Lys31Arg) is suggested for males because of their heterozygous mothers carrying the mutant alleles. METHOD: Whole Exome Sequencing (WES) was done for a 25-year-old female followed by the screening of the novel mutation in her parents and her brother by the Sanger sequencing technique...
January 23, 2024: Current Aging Science
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
