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https://www.readbyqxmd.com/read/29324895/continental-synchronicity-of-human-influenza-virus-epidemics-despite-climactic-variation
#1
Jemma L Geoghegan, Aldo F Saavedra, Sebastián Duchêne, Sheena Sullivan, Ian Barr, Edward C Holmes
The factors that determine the pattern and rate of spread of influenza virus at a continental-scale are uncertain. Although recent work suggests that influenza epidemics in the United States exhibit a strong geographical correlation, the spatiotemporal dynamics of influenza in Australia, a country and continent of approximately similar size and climate complexity but with a far smaller population, are not known. Using a unique combination of large-scale laboratory-confirmed influenza surveillance comprising >450,000 entries and genomic sequence data we determined the local-level spatial diffusion of this important human pathogen nationwide in Australia...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29315575/the-appswe-ps1a246e-mutations-in-an-astrocytic-cell-line-leads-to-increased-vulnerability-to-oxygen-and-glucose-deprivation-ca2-dysregulation-and-mitochondrial-abnormalities
#2
María Dolores Martin-de-Saavedra, Elisa Navarro, Ana J Moreno-Ortega, Mauricio P Cunha, Izaskun Buendia, Pablo Hernansanz-Agustín, Rafael León, María F Cano-Abad, Antonio Martínez-Ruiz, Ricardo Martínez-Murillo, Michael R Duchen, Manuela G López
Growing evidence suggests a close relationship between Alzheimer's Disease (AD) and cerebral hypoxia. Astrocytes play a key role in brain homeostasis and disease states, while some of the earliest changes in AD occur in astrocytes. We have therefore asked whether mutations associated with AD increase astrocyte vulnerability to ischemia. Two astroglioma cell lines derived from APPSWE /PS1A246E (APP, amyloid precursor protein; PS1, presenilin 1) transgenic mice and controls from normal mice were subjected to oxygen and glucose deprivation (OGD), an in vitro model of ischemia...
January 6, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29300782/the-paradox-of-hbv-evolution-as-revealed-from-a-16th-century-mummy
#3
Zoe Patterson Ross, Jennifer Klunk, Gino Fornaciari, Valentina Giuffra, Sebastian Duchêne, Ana T Duggan, Debi Poinar, Mark W Douglas, John-Sebastian Eden, Edward C Holmes, Hendrik N Poinar
Hepatitis B virus (HBV) is a ubiquitous viral pathogen associated with large-scale morbidity and mortality in humans. However, there is considerable uncertainty over the time-scale of its origin and evolution. Initial shotgun data from a mid-16th century Italian child mummy, that was previously paleopathologically identified as having been infected with Variola virus (VARV, the agent of smallpox), showed no DNA reads for VARV yet did for hepatitis B virus (HBV). Previously, electron microscopy provided evidence for the presence of VARV in this sample, although similar analyses conducted here did not reveal any VARV particles...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29244187/polycytidylation-of-mitochondrial-mrnas-in-chlamydomonas-reinhardtii
#4
Thalia Salinas-Giegé, Marina Cavaiuolo, Valérie Cognat, Elodie Ubrig, Claire Remacle, Anne-Marie Duchêne, Olivier Vallon, Laurence Maréchal-Drouard
The unicellular photosynthetic organism, Chlamydomonas reinhardtii, represents a powerful model to study mitochondrial gene expression. Here, we show that the 5'- and 3'-extremities of the eight Chlamydomonas mitochondrial mRNAs present two unusual characteristics. First, all mRNAs start primarily at the AUG initiation codon of the coding sequence which is often marked by a cluster of small RNAs. Second, unusual tails are added post-transcriptionally at the 3'-extremity of all mRNAs. The nucleotide composition of the tails is distinct from that described in any other systems and can be partitioned between A/U-rich tails, predominantly composed of Adenosine and Uridine, and C-rich tails composed mostly of Cytidine...
December 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29243391/bayesian-molecular-dating-opening-up-the-black-box
#5
Lindell Bromham, Sebastián Duchêne, Xia Hua, Andrew M Ritchie, David A Duchêne, Simon Y W Ho
Molecular dating analyses allow evolutionary timescales to be estimated from genetic data, offering an unprecedented capacity for investigating the evolutionary past of all species. These methods require us to make assumptions about the relationship between genetic change and evolutionary time, often referred to as a 'molecular clock'. Although initially regarded with scepticism, molecular dating has now been adopted in many areas of biology. This broad uptake has been due partly to the development of Bayesian methods that allow complex aspects of molecular evolution, such as variation in rates of change across lineages, to be taken into account...
December 15, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29229998/guidelines-on-experimental-methods-to-assess-mitochondrial-dysfunction-in-cellular-models-of-neurodegenerative-diseases
#6
REVIEW
Niamh M C Connolly, Pierre Theurey, Vera Adam-Vizi, Nicolas G Bazan, Paolo Bernardi, Juan P Bolaños, Carsten Culmsee, Valina L Dawson, Mohanish Deshmukh, Michael R Duchen, Heiko Düssmann, Gary Fiskum, Maria F Galindo, Giles E Hardingham, J Marie Hardwick, Mika B Jekabsons, Elizabeth A Jonas, Joaquin Jordán, Stuart A Lipton, Giovanni Manfredi, Mark P Mattson, BethAnn McLaughlin, Axel Methner, Anne N Murphy, Michael P Murphy, David G Nicholls, Brian M Polster, Tullio Pozzan, Rosario Rizzuto, Jorgina Satrústegui, Ruth S Slack, Raymond A Swanson, Russell H Swerdlow, Yvonne Will, Zheng Ying, Alvin Joselin, Anna Gioran, Catarina Moreira Pinho, Orla Watters, Manuela Salvucci, Irene Llorente-Folch, David S Park, Daniele Bano, Maria Ankarcrona, Paola Pizzo, Jochen H M Prehn
Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been implicated in most neurodegenerative diseases, but in many instances it is unclear whether such dysfunction is a cause or an effect of the underlying pathology, and whether it represents a viable therapeutic target. It is therefore imperative to utilise and optimise cellular models and experimental techniques appropriate to determine the contribution of mitochondrial dysfunction to neurodegenerative disease phenotypes...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29167227/pericardial-adipose-tissue-regulates-granulopoiesis-fibrosis-and-cardiac-function-after-myocardial-infarction
#7
Michael Horckmans, Mariaelvy Bianchini, Donato Santovito, Remco T A Megens, Jean-Yves Springael, Irene Negri, Michele Vacca, Marco Di Eusanio, Antonio Moschetta, Christian Weber, Johan Duchene, Sabine Steffens
Background -The pericardial adipose tissue (AT) contains a high density of lymphoid clusters. Is unknown whether these clusters play a role in post-myocardial infarction (MI) inflammatory responses and cardiac outcome. Methods -Lymphoid clusters were examined in epicardial AT of humans with or without coronary artery disease (CAD). Murine pericardial lymphoid clusters were visualized in mice subjected to coronary artery ligation. To study the relevance of pericardial clusters during inflammatory responses after MI, we surgically removed the pericardial AT, performed B cell depletion and GM-CSF blockade...
November 22, 2017: Circulation
https://www.readbyqxmd.com/read/29160571/sacral-neuromodulation-and-pregnancy-results-of-a-national-survey-carried-out-for-the-neuro-urology-committee-of-the-french-association-of-urology-afu
#8
Pauline Roulette, Evelyne Castel-Lacanal, Sylvain Sanson, Romain Caremel, Véronique Phé, Stéphane Bart, Franck Duchêne, Marianne De Sèze, Alexia Even, Andréa Manunta, Maria C Scheiber-Nogueira, Pascal Mouracade, Catherine-Marie Loche, Emmanuel Chartier-Kastler, Alain Ruffion, Gilles Karsenty, Xavier Gamé
AIMS: To assess the impact of sacral neuromodulation (SNM) on pregnancy and vice-versa, by identifying women who had received SNM for lower-urinary tract symptoms (LUTS) and had become pregnant. METHODS: A cross-sectional descriptive study was carried out based on responses to an on-line questionnaire sent to practitioners listed on the InterStim enCaptureTM National Registry. Questions were related to pre-pregnancy health and SNM efficacy, deactivation of the device, its impact on LUTS, childbirth, the infant, its reactivation and postpartum effectiveness...
November 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29132802/-prophylactic-radiotherapy-in-a-single-fraction-of-10gy-at-intervention-pleural-site-in-patient-with-malignant-pleural-mesothelioma-a-retrospective-monocentric-cohort-study
#9
H Carette, J-C Faivre, J Salleron, A-S Baumann, L Uwer, C Clément-Duchêne, J-M Vignaud, I Petit, J Siat, A Tiotiu, V Beckendorf
PURPOSE: Prophylactic radiotherapy to prevent procedure-tracts metastases from malignant pleural mesothelioma remains controversial and clinical practice varies. The purpose was to assess the efficacy of local radiotherapy in a single fraction of 10Gy in preventing malignant seeding at intervention pleural site in patients with malignant pleural mesothelioma. MATERIAL AND METHODS: This is a retrospective cohort study, including patients with histological confirmed malignant pleural mesothelioma treated by prophylactic irradiation to prevent interventional site metastases with a unique fraction of 10Gy with 6 to 18MeV, from January 1990 to December 2013 in the institut de cancérologie de Lorraine (Nancy, France)...
November 10, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29117929/a-fully-automated-web-based-program-improves-lifestyle-habits-and-hba1c-in-patients-with-type-2-diabetes-and-abdominal-obesity-randomized-trial-of-patient-e-coaching-nutritional-support-the-anode-study
#10
Boris Hansel, Philippe Giral, Laetitia Gambotti, Alexandre Lafourcade, Gilbert Peres, Claude Filipecki, Diana Kadouch, Agnes Hartemann, Jean-Michel Oppert, Eric Bruckert, Michel Marre, Arnaud Bruneel, Emilie Duchene, Ronan Roussel
BACKGROUND: The prevalence of abdominal obesity and type 2 diabetes mellitus (T2DM) is a public health challenge. New solutions need to be developed to help patients implement lifestyle changes. OBJECTIVE: The objective of the study was to evaluate a fully automated Web-based intervention designed to help users improve their dietary habits and increase their physical activity. METHODS: The Accompagnement Nutritionnel de l'Obésité et du Diabète par E-coaching (ANODE) study was a 16-week, 1:1 parallel-arm, open-label randomized clinical trial...
November 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29067670/from-grna-identification-to-the-restoration-of-dystrophin-expression-a-dystrophin-gene-correction-strategy-for-duchenne-muscular-dystrophy-mutations-using-the-crispr-induced-deletion-method
#11
Benjamin Duchêne, Jean-Paul Iyombe-Engembe, Joël Rousseau, Jacques P Tremblay, Dominique L Ouellet
The discovery of the CRISPR-Cas9 system raises hope for the treatment of many genetic disorders. We describe here an approach based on the use of a pair of single guide RNAs to form a hybrid exon that does not only restore the dystrophin gene reading frame but also results in the production of a dystrophin protein with an adequate structure of the central rod-domain, with a correct spectrin-like repeat. The therapeutic approach described here involved DMD patient cells having a deletion of exons 51-53 of the DMD gene...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29044717/a-genome-scale-analysis-of-mrnas-targeting-to-plant-mitochondria-upstream-augs-in-5-utrs-reduce-mitochondrial-association
#12
Timothée Vincent, Audrey Vingadassalon, Elodie Ubrig, Kevin Azeredo, Ola Srour, Valérie Cognat, Stéfanie Graindorge, Thalia Salinas, Laurence Maréchal-Drouard, Anne-Marie Duchêne
Intracellular sorting of mRNAs is an essential process to regulate gene expression and protein localization. Most of mitochondrial proteins are nuclear-encoded and imported into mitochondria, through post-translational or co-translational processes. In the latter case, mRNAs are found enriched in the vicinity of mitochondria. A genome-scale analysis of mRNAs associated with mitochondria has been performed to determine plant cytosolic mRNAs targeted to the mitochondrial surface. Many messengers encoding mitochondrial proteins were found associated with mitochondria...
October 17, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29040651/the-chlamydomonas-mex1-mutant-shows-impaired-starch-mobilization-without-maltose-accumulation
#13
Justin Findinier, Hande Tunçay, Miriam Schulz-Raffelt, Philippe Deschamps, Corentin Spriet, Jean-Marie Lacroix, Thierry Duchêne, Nicolas Szydlowski, Yonghua Li-Beisson, Gilles Peltier, Christophe D'Hulst, Fabrice Wattebled, David Dauvillée
The MEX1 locus of Chlamydomonas reinhardtii was identified in a genetic screen as a factor that affects starch metabolism. Mutation of MEX1 causes a slow-down in the mobilization of storage polysaccharide. Cosegregation and functional complementation analyses were used to assess the involvement of the Mex1 protein in starch degradation. Heterologous expression experiments performed in Escherichia coli and Arabidopsis thaliana allowed us to test the capacity of the algal protein in maltose export. In contrast to the A...
October 5, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29029231/analysis-of-phylogenomic-tree-space-resolves-relationships-among-marsupial-families
#14
David A Duchêne, Jason G Bragg, Sebastián Duchêne, Linda E Neaves, Sally Potter, Craig Moritz, Rebecca N Johnson, Simon Y W Ho, Mark D B Eldridge
A fundamental challenge in resolving evolutionary relationships across the Tree of Life is to account for heterogeneity in the evolutionary signal across loci. Studies of marsupial mammals have demonstrated that this heterogeneity can be substantial, leaving considerable uncertainty in the evolutionary timescale and relationships within the group. Using simulations and a new phylogenomic data set comprising nucleotide sequences of 1550 loci from 18 of the 22 extant marsupial families, we demonstrate the power of a method for identifying clusters of loci that support different phylogenetic trees...
September 22, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28971018/a-new-version-of-the-grapevine-reference-genome-assembly-12x-v2-and-of-its-annotation-vcost-v3
#15
A Canaguier, J Grimplet, G Di Gaspero, S Scalabrin, E Duchêne, N Choisne, N Mohellibi, C Guichard, S Rombauts, I Le Clainche, A Bérard, A Chauveau, R Bounon, C Rustenholz, M Morgante, M-C Le Paslier, D Brunel, A-F Adam-Blondon
No abstract text is available yet for this article.
December 2017: Genomics Data
https://www.readbyqxmd.com/read/28962745/editorial-special-edition-of-international-journal-of-pharmaceutics-in-honor-of-professor-dominique-duch%C3%A3%C2%AAne
#16
EDITORIAL
Ruxandra Gref, Patrick Couvreur, Thorsteinn Loftsson
No abstract text is available yet for this article.
October 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28935262/identification-of-the-period-of-stability-in-a-balance-test-after-stepping-up-using-a-simplified-cumulative-sum
#17
Doha Safieddine, Aly Chkeir, Cyrille Herlem, Delphine Bera, Michèle Collart, Jean-Luc Novella, Moustapha Dramé, David J Hewson, Jacques Duchêne
Falls are a major cause of death in older people. One method used to predict falls is analysis of Centre of Pressure (CoP) displacement, which provides a measure of balance quality. The Balance Quality Tester (BQT) is a device based on a commercial bathroom scale that calculates instantaneous values of vertical ground reaction force (Fz) as well as the CoP in both anteroposterior (AP) and mediolateral (ML) directions. The entire testing process needs to take no longer than 12 s to ensure subject compliance, making it vital that calculations related to balance are only calculated for the period when the subject is static...
November 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28874733/mitochondrial-permeability-transition-pore-sensitivity-to-opening-and-mechanistic-dependence-on-substrate-availability
#18
Thomas Briston, Malcolm Roberts, Sian Lewis, Ben Powney, James M Staddon, Gyorgy Szabadkai, Michael R Duchen
Mitochondrial Ca(2+) uptake has a key role in cellular Ca(2+) homeostasis. Excessive matrix Ca(2+) concentrations, especially when coincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conductance channel: the mitochondrial permeability transition pore (mPTP). mPTP opening has been implicated as a final cell death pathway in numerous diseases and therefore understanding conditions dictating mPTP opening is crucial for developing targeted therapies. Here, we have investigated the impact of mitochondrial metabolic state on the probability and consequences of mPTP opening...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869944/evidence-for-concerted-and-mosaic-brain-evolution-in-dragon-lizards
#19
Daniel Hoops, Marta Vidal-García, Jeremy F P Ullmann, Andrew L Janke, Timothy Stait-Gardner, David A Duchêne, William S Price, Martin J Whiting, J Scott Keogh
The brain plays a critical role in a wide variety of functions including behaviour, perception, motor control, and homeostatic maintenance. Each function can undergo different selective pressures over the course of evolution, and as selection acts on the outputs of brain function, it necessarily alters the structure of the brain. Two models have been proposed to explain the evolutionary patterns observed in brain morphology. The concerted brain evolution model posits that the brain evolves as a single unit and the evolution of different brain regions are coordinated...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28774861/multidisciplinary-tumor-board-decision-making-for%C3%A2-postoperative-radiotherapy-in-thymic-epithelial%C3%A2-tumors-insights-from-the-rythmic-prospective-cohort
#20
Clémence Basse, Sébastien Thureau, Suzanna Bota, Eric Dansin, Pascal-Alexandre Thomas, Eric Pichon, Hervé Lena, Carole Massabeau, Christelle Clément-Duchene, Gilbert Massard, Virginie Westeel, Xavier Quantin, Youssef Oulkhouir, Serge Danhier, Delphine Lerouge, Ronan Tanguy, François Thillays, Cécile Le Pechoux, Bernard Dubray, Luc Thiberville, Benjamin Besse, Nicolas Girard
INTRODUCTION: Thymic epithelial tumors (TETs) are rare intrathoracic malignancies for which surgery represents the mainstay of the treatment. Current practice for postoperative radiotherapy (PORT) is highly variable, and there is a lack of prospective, high level evidence. Réseau Tumeurs Thymiques et Cancer (RYTHMIC) is the nationwide network for TETs in France. Established in 2012, it prospectively collects data on all TET patients, for whom management is discussed at a national multidisciplinary tumor board (MTB)...
November 2017: Journal of Thoracic Oncology
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