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https://www.readbyqxmd.com/read/27560494/sur1-associated-mechanisms-are-not-involved-in-ischemic-optic-neuropathy-1-day-post-injury
#1
James D Nicholson, Yan Guo, Steven L Bernstein
Ischemia-reperfusion injury after central nervous system (CNS) injury presents a major health care challenge with few promising treatments. Recently, it has become possible to reduce edema after CNS injury by antagonizing a sulfonylurea receptor 1 (SUR1) regulated ion channel expressed after injury. SUR1 upregulation after injury is a necessary precondition for the formation of this channel, and has been implicated in white matter injury after clinical spinal cord trauma. Glibenclamide, an SUR1 antagonist, appears to have neuroprotective effect against cerebral stroke in an open-label small clinical trial and great effectiveness in reducing damage after varied experimental CNS injury models...
2016: PloS One
https://www.readbyqxmd.com/read/27335313/possible-involvement-of-the-hmgb1-rage-signaling-mechanism-in-the-induction-of-central-post-stroke-pain-induced-by-acute-global-cerebral-ischemia
#2
Shinichi Harada, Wataru Matsuura, Keyue Liu, Masahiro Nishibori, Shogo Tokuyama
Central post-stroke pain (CPSP) is one of the most under-recognized consequences of cerebral stroke, but the development of an effective treatment strategy is urgent. High-mobility group box 1 (HMGB1) and the receptor for advanced glycation end products (RAGE, one of the receptors of HMGB1) have recently been shown to be critical in the modulation of nociceptive transduction following peripheral neuropathy. The aim of this study was to determine the interactions between CPSP and HMGB1/RAGE signaling. Male ddY mice were subjected to 30min of bilateral carotid artery occlusion (BCAO)...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27252982/sagittal-balance-is-more-than-just-alignment-why-pjk-remains-an-unresolved-problem
#3
Steven D Glassman, Mark P Coseo, Leah Y Carreon
BACKGROUND: The durability of adult spinal deformity surgery remains problematic. Revision rates above 20 % have been reported, with a range of causes including wound infection, nonunion and adjacent level pathology. While some of these complications have been amenable to changes in patient selection or surgical technique, Proximal Junctional Kyphosis (PJK) remains an unresolved challenge. This study examines the contributions of non-mechanical factors to the incidence of postoperative sagittal imbalance and PJK after adult deformity surgery...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/26924998/psychological-treatments-and-psychotherapies-in-the-neurorehabilitation-of-pain-evidences-and-recommendations-from-the-italian-consensus-conference-on-pain-in-neurorehabilitation
#4
REVIEW
Gianluca Castelnuovo, Emanuele M Giusti, Gian Mauro Manzoni, Donatella Saviola, Arianna Gatti, Samantha Gabrielli, Marco Lacerenza, Giada Pietrabissa, Roberto Cattivelli, Chiara A M Spatola, Stefania Corti, Margherita Novelli, Valentina Villa, Andrea Cottini, Carlo Lai, Francesco Pagnini, Lorys Castelli, Mario Tavola, Riccardo Torta, Marco Arreghini, Loredana Zanini, Amelia Brunani, Paolo Capodaglio, Guido E D'Aniello, Federica Scarpina, Andrea Brioschi, Lorenzo Priano, Alessandro Mauro, Giuseppe Riva, Claudia Repetto, Camillo Regalia, Enrico Molinari, Paolo Notaro, Stefano Paolucci, Giorgio Sandrini, Susan G Simpson, Brenda Wiederhold, Stefano Tamburin
BACKGROUND: It is increasingly recognized that treating pain is crucial for effective care within neurological rehabilitation in the setting of the neurological rehabilitation. The Italian Consensus Conference on Pain in Neurorehabilitation was constituted with the purpose identifying best practices for us in this context. Along with drug therapies and physical interventions, psychological treatments have been proven to be some of the most valuable tools that can be used within a multidisciplinary approach for fostering a reduction in pain intensity...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/26673042/prevalence-of-complications-and-clinical-audit-of-management-of-type-2-diabetes-mellitus-a-prospective-hospital-based-study
#5
Malini Kulshrestha, Seema Seth, Ashutosh Tripathi, Anindita Seth, Anoop Kumar
INTRODUCTION: Management of type 2 diabetes mellitus (DM) needs multi factorial risk reduction strategies like weight reduction, blood pressure (BP) control and lipid profile regulation, along with glycaemic control. These strategies should be implemented very early in the course of the disease to prevent both microvascular and macro vascular complications. AIM: To find out the prevalence of diabetic complications and to audit the management of glycaemia, blood pressure and serum lipids in the outpatient diabetes clinic in a hospital located in Western U...
November 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26648474/neuroimmune-crosstalk-in-cns-disorders-the-histamine-connection
#6
Ramón Cacabelos, Clara Torrellas, Lucía Fernández-Novoa, Gjumrakch Aliev
The neuroimmune system represents a dense network of biochemical signals associated with neurotransmitters, neuropeptides, neurohormones, cytokines, chemokines, and growth factors synthesized in neurons, glial cells and immune cells, to maintain systemic homeostasis. Endogenous and/or exogenous, noxious stimuli in any tissue are captured by sensor cells to inform the brain; likewise, signals originating at the central nervous system (CNS) level are transmitted to peripheral immune effectors which react to central stimuli...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26134256/botulinum-toxin-type-a-for-the-treatment-of-neuropathic-pain-in-neuro-rehabilitation
#7
REVIEW
Domenico Intiso, Mario Basciani, Andrea Santamato, Marta Intiso, Filomena Di Rienzo
Pain is a natural protective mechanism and has a warning function signaling imminent or actual tissue damage. Neuropathic pain (NP) results from a dysfunction and derangement in the transmission and signal processing along the nervous system and it is a recognized disease in itself. The prevalence of NP is estimated to be between 6.9% and 10% in the general population. This condition can complicate the recovery from stroke, multiple sclerosis, spinal cord lesions, and several neuropathies promoting persistent disability and poor quality of life...
July 2015: Toxins
https://www.readbyqxmd.com/read/26005122/-american-academy-of-neurology-washington-18-25%C3%A2-april%C3%A2-2015
#8
I Sibon, B de Toffol, J-P Azulay, F Sellal, C Thomas-Antérion, J-M Léger, C Pierrot-Deseilligny
CEREBROVASCULAR DISEASES: The benefit of the thrombectomy using stents retrievers in the acute stroke phase is now demonstrated when there is a proximal occlusion of an intracranial artery, whatever its mechanism. The place of the anticoagulants in the management of cervical artery dissections remains uncertain, while the benefit of the blood pressure control in the secondary prevention of deep and lobar intracerebral hemorrhages is critical. The development of cardiac MRI, prolonged cardiac monitoring and transcranial doppler seems to improve the diagnosis of cardio-embolic sources of stroke...
June 2015: Revue Neurologique
https://www.readbyqxmd.com/read/25599303/results-availability-for-analgesic-device-complex-regional-pain-syndrome-and-post-stroke-pain-trials-comparing-the-rreads-rreact-and-rremit-databases
#9
COMPARATIVE STUDY
Faustine L Dufka, Troels Munch, Robert H Dworkin, Michael C Rowbotham
Evidence-based medicine rests on the assumption that treatment recommendations are robust, free from bias, and include results of all randomized clinical trials. The Repository of Registered Analgesic Clinical Trials search and analysis methodology was applied to create databases of complex regional pain syndrome (CRPS) and central post-stroke pain (CPSP) trials and adapted to create the Repository of Registered Analgesic Device Studies databases for trials of spinal cord stimulation (SCS), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS)...
January 2015: Pain
https://www.readbyqxmd.com/read/25482254/diagnosis-and-management-of-neuropathic-pain-review-of-literature-and-recommendations-of-the-polish-association-for-the-study-of-pain-and-the-polish-neurological-society-part-two
#10
REVIEW
Andrzej Szczudlik, Jan Dobrogowski, Jerzy Wordliczek, Adam Stępień, Małgorzata Krajnik, Wojciech Leppert, Jarosław Woroń, Anna Przeklasa-Muszyńska, Magdalena Kocot-Kępska, Renata Zajączkowska, Marcin Janecki, Anna Adamczyk, Małgorzata Malec-Milewska
Neuropathic pain may be caused by a variety of lesions or diseases of both the peripheral and central nervous system. The most common and best known syndromes of peripheral neuropathic pain are painful diabetic neuropathy, trigeminal and post-herpetic neuralgia, persistent post-operative and post-traumatic pain, complex regional pain syndrome, cancer-related neuropathic pain, HIV-related neuropathic pain and pain after amputation. The less common central pain comprises primarily central post-stroke pain, pain after spinal cord injury, central pain in Parkinson disease or in other neurodegenerative diseases, pain in syringomyelia and in multiple sclerosis...
2014: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/24719027/carbamazepine-for-chronic-neuropathic-pain-and-fibromyalgia-in-adults
#11
REVIEW
Philip J Wiffen, Sheena Derry, R Andrew Moore, Eija A Kalso
BACKGROUND: This is an update of a Cochrane review entitled 'Carbamazepine for acute and chronic pain in adults' published in Issue 1, 2011. Some antiepileptic medicines have a place in the treatment of neuropathic pain (pain due to nerve damage). This updated review considers the treatment of chronic neuropathic pain and fibromyalgia only, and adds no new studies. The update uses higher standards of evidence than the earlier review, which results in the exclusion of five studies that were previously included...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24365414/neurologic-aspects-of-heart-transplantation
#12
REVIEW
Alain Heroux, Salpy V Pamboukian
Cardiac transplantation remains the best treatment option for patients with end-stage, NYHA class IV heart failure who have failed conventional therapy. However, transplant rates have remained static largely due to limited organ donor supplies. Therefore, appropriate allocation of this precious resource is critical to maximize benefit, both at a patient level and at a societal level. Neurologic diseases, such as cerebrovascular disease and peripheral neuropathy, are prevalent in this patient population, as the major risk factors for heart disease place patients at risk for neurologic disease as well...
2014: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/24297457/lamotrigine-for-chronic-neuropathic-pain-and-fibromyalgia-in-adults
#13
REVIEW
Philip J Wiffen, Sheena Derry, R Andrew Moore
BACKGROUND: This is an update of the original Cochrane review entitled Lamotrigine for acute and chronic pain published in Issue 2, 2007, and updated in Issue 2, 2011. Some antiepileptic medicines have a place in the treatment of neuropathic pain (pain due to nerve damage). This updated review adds no new additional studies looking at evidence for lamotrigine as an effective treatment for chronic neuropathic pain or fibromyalgia. The update uses higher standards of evidence than previously...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23973747/rhoa-activity-and-post-ischemic-inflammation-in-an-experimental-model-of-adult-rodent-anterior-ischemic-optic-neuropathy
#14
Masoud Aghsaei Fard, Katayoon Baradaran Ebrahimi, Neil R Miller
Activation of inflammatory cells and the RhoA signaling pathway may contribute to optic nerve damage following non-arteritic anterior ischemic optic neuropathy (NAION). We induced an optic nerve infarct with a photothrombotic mechanism in a rat model of AION (rAION). Immunohistochemistry and Western blot were performed to detect activation of RhoA signaling and inflammation. The extent of Rho activity, inflammation, retinal ganglion cell (RGC) loss and extent of axon regeneration were determined at 8 and 14 days after infarct...
October 9, 2013: Brain Research
https://www.readbyqxmd.com/read/23707145/brain-white-matter-oedema-due-to-clc-2-chloride-channel-deficiency-an-observational-analytical-study
#15
Christel Depienne, Marianna Bugiani, Céline Dupuits, Damien Galanaud, Valérie Touitou, Nienke Postma, Carola van Berkel, Emiel Polder, Eleonore Tollard, Frédéric Darios, Alexis Brice, Christine E de Die-Smulders, Johannes S Vles, Adeline Vanderver, Graziella Uziel, Cengiz Yalcinkaya, Suzanna G Frints, Vera M Kalscheuer, Jan Klooster, Maarten Kamermans, Truus Em Abbink, Nicole I Wolf, Frédéric Sedel, Marjo S van der Knaap
BACKGROUND: Mutant mouse models suggest that the chloride channel ClC-2 has functions in ion and water homoeostasis, but this has not been confirmed in human beings. We aimed to define novel disorders characterised by distinct patterns of MRI abnormalities in patients with leukoencephalopathies of unknown origin, and to identify the genes mutated in these disorders. We were specifically interested in leukoencephalopathies characterised by white matter oedema, suggesting a defect in ion and water homoeostasis...
July 2013: Lancet Neurology
https://www.readbyqxmd.com/read/23703410/intravenous-infusions-in-chronic-pain-management
#16
REVIEW
Boleslav Kosharskyy, Wilson Almonte, Naum Shaparin, Marco Pappagallo, Howard Smith
In the United States, millions of Americans are affected by chronic pain, which adds heavily to national rates of morbidity, mortality, and disability, with an ever-increasing prevalence. According to a 2011 report titled Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research by the Institute of Medicine of the National Academies, pain not only exacts its toll on people's lives but also on the economy with an estimated annual economic cost of at least $560 - 635 billion in health care costs and the cost of lost productivity attributed to chronic pain...
May 2013: Pain Physician
https://www.readbyqxmd.com/read/23537119/bilateral-central-pain-sensitization-in-rats-following-a-unilateral-thalamic-lesion-may-be-treated-with-high-doses-of-ketamine
#17
Aude Castel, Pierre Hélie, Francis Beaudry, Pascal Vachon
BACKGROUND: Central post-stroke pain is a neuropathic pain condition caused by a vascular lesion, of either ischemic or hemorrhagic origin, in the central nervous system and more precisely involving the spinothalamocortical pathway responsible for the transmission of painful sensations. Few animal models have been developed to study this problem. The objectives of this study were to evaluate different modalities of pain in a central neuropathic pain rat model and to assess the effects of ketamine administered at different doses...
2013: BMC Veterinary Research
https://www.readbyqxmd.com/read/23284631/pgj-2-provides-prolonged-cns-stroke-protection-by-reducing-white-matter-edema
#18
James D Nicholson, Adam C Puche, Yan Guo, Daniel Weinreich, Bernard J Slater, Steven L Bernstein
Few clinically effective approaches reduce CNS-white matter injury. After early in-vivo white matter infarct, NFκB-driven pro-inflammatory signals can amplify a relatively small amount of vascular damage, resulting in progressive endothelial dysfunction to create a severe ischemic lesion. This process can be minimized by 15-deoxy-Δ(12,14)-prostaglandin J2 (PGJ(2)), an analog of the metabolically active PGD(2) metabolite. We evaluated PGJ(2)'s effects and mechanisms using rodent anterior ischemic optic neuropathy (rAION); an in vivo white matter ischemia model...
2012: PloS One
https://www.readbyqxmd.com/read/23235657/amitriptyline-for-neuropathic-pain-and-fibromyalgia-in-adults
#19
REVIEW
R Andrew Moore, Sheena Derry, Dominic Aldington, Peter Cole, Philip J Wiffen
BACKGROUND: Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines. These types of pain can be treated with antidepressant drugs in doses below those at which the drugs act as antidepressants. OBJECTIVES: To assess the analgesic efficacy of amitriptyline for chronic neuropathic pain and fibromyalgia.To assess the adverse events associated with the clinical use of amitriptyline for chronic neuropathic pain and fibromyalgia...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/22097108/-contemporary-treatment-neuropathic-pain
#20
REVIEW
Milan Cvijanović, Svetlana Simić, Sofija Banić Horvat, Zita Jovin, Petar Slankamenac, Miroslav Ilin
INTRODUCTION: Neuropathic pain, or pain associated with disease or injury to the peripheral or central nervous system, is a common symptom of a heterogeneous group of conditions, including diabetic neuropathy; trigeminal neuralgia, postherpetic neuralgia and spinal cord injury. Chronic neuropathic pain should not be thought of as a symptom. It should truly be thought of as a disease with a very complicated pathophysiology. PATHOPHYSIOLOGY: The mechanisms involved in neuropathic pain are complex and involve both peripheral and central pathophysiologic phenomenon...
September 2011: Medicinski Pregled
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