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https://www.readbyqxmd.com/read/28087936/fungal-ligninolytic-enzymes-and-their-applications
#1
Miia R Mäkelä, Erin L Bredeweg, Jon K Magnuson, Scott E Baker, Ronald P de Vries, Kristiina Hildén
The global push toward an efficient and economical biobased economy has driven research to develop more cost-effective applications for the entirety of plant biomass, including lignocellulosic crops. As discussed elsewhere (Karlsson M, Atanasova L, Funck Jensen D, Zeilinger S, in Heitman J et al. [ed], Tuberculosis and the Tubercle Bacillus, 2nd ed, in press), significant progress has been made in the use of polysaccharide fractions from lignocellulose, cellulose, and various hemicellulose types. However, developing processes for use of the lignin fraction has been more challenging...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28065654/challenging-cardiac-function-post-spinal-cord-injury-with-dobutamine
#2
Kathryn M DeVeau, Emily K Martin, Nicholas T King, Alice Shum-Siu, Bradley B Keller, Christopher R West, David S K Magnuson
There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart, which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under enhanced sympathetic activity we utilized dobutamine (DOB) stress echocardiography. Animals were divided into a T2, 25g-cm contusive SCI (SCI) or an uninjured control (CON) group. Echocardiography was performed pre-SCI and at 1, 2 and 6weeks post-SCI. Increasing doses of DOB (5, 10 & 20μg/min/kg) were infused intravenously pre-SCI and at 1 and 6weeks post-SCI...
December 23, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28056053/soluble-b-and-t-lymphocyte-attenuator-correlates-to-disease-severity-in-sepsis-and-high-levels-are-associated-with-an-increased-risk-of-mortality
#3
Anna Lange, Jonas Sundén-Cullberg, Anders Magnuson, Olof Hultgren
INTRODUCTION AND AIMS: B- and T-lymphocyte Attenuator (BTLA), Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1 (PD-1) are co-inhibitory receptors that regulate T cell activation. In the present study of ICU-treated patients we measured plasma concentrations of their soluble isoforms, with the aim to evaluate their potential as sepsis biomarkers and utility as prognostic indicators. METHODS: 101 patients with sepsis, 28 patients with non-infectious critical illness (ICU controls) and 31 blood donors (healthy controls, HC) were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28055303/gene-length-as-a-biological-timer-to-establish-temporal-transcriptional-regulation
#4
Killeen S Kirkconnell, Brian Magnuson, Michelle T Paulsen, Brian Lu, Karan Bedi, Mats Ljungman
Transcriptional timing is inherently influenced by gene length, thus providing a mechanism for temporal regulation of gene expression. While gene size has been shown to be important for the expression timing of specific genes during early development, whether it plays a role in the timing of other global gene expression programs has not been extensively explored. Here, we investigate the role of gene length during the early transcriptional response of human fibroblasts to serum stimulation. Using the nascent sequencing techniques Bru-seq and BruUV-seq, we identified immediate genome-wide transcriptional changes following serum stimulation that were linked to rapid activation of enhancer elements...
January 5, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28050027/a-newly-recognized-association-of-hirschsprung-disease-with-cri-du-chat-syndrome
#5
Imdad Ullah, Lori Mahajan, David Magnuson
No abstract text is available yet for this article.
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28040795/weighing-risk-of-cardiovascular-mortality-against-potential-benefit-of-hormonal-therapy-in-intermediate-risk-prostate-cancer
#6
Nataniel H Lester-Coll, Skyler Johnson, William J Magnuson, Samuel Z Goldhaber, David J Sher, Anthony V D'Amico, James B Yu
BACKGROUND: The purpose of this study is to determine the optimal strategy for men with newly diagnosed intermediate-risk prostate cancer by age and cardiac risk. METHODS: A Markov model was calibrated to the EORTC 22991 trial, which randomly assigned men with intermediate-risk prostate cancer to radiation therapy (RT) with or without six months of hormonal therapy (HT). We compared quality-adjusted life-years (QALYs) in men age 50, 60, and 70 years by age decile and cardiac risk group...
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28034450/epiploic-appendagitis-a-rare-cause-of-chronic-right-lower-quadrant-pain-in-a-child
#7
Imdad Ullah, Lori Mahajan, David Magnuson
No abstract text is available yet for this article.
December 26, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/28029304/cognitive-complaints-in-survivors-of-breast-cancer-after-chemotherapy-compared-with-age-matched-controls-an-analysis-from-a-nationwide-multicenter-prospective-longitudinal-study
#8
Michelle C Janelsins, Charles E Heckler, Luke J Peppone, Charles Kamen, Karen M Mustian, Supriya G Mohile, Allison Magnuson, Ian R Kleckner, Joseph J Guido, Kelley L Young, Alison K Conlin, Lora R Weiselberg, Jerry W Mitchell, Christine A Ambrosone, Tim A Ahles, Gary R Morrow
Purpose Cancer-related cognitive impairment is an important problem for patients with breast cancer, yet its trajectory is not fully understood. Some previous cancer-related cognitive impairment research is limited by heterogeneous populations, small samples, lack of prechemotherapy and longitudinal assessments, use of normative data, and lack of generalizability. We addressed these limitations in a large prospective, longitudinal, nationwide study. Patients and Methods Patients with breast cancer from community oncology clinics and age-matched noncancer controls completed the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) at prechemotherapy and postchemotherapy and at a 6-month follow-up as an a priori exploratory aim...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28009138/intracorporeal-hybrid-single-port-vs-conventional-laparoscopic-appendectomy-in-children
#9
Paul Anthony Karam, Amy Hiuser, David Magnuson, Federico Gian Filippo Seifarth
Transumbilical laparoscopic assisted appendectomy combines laparoscopic single port dissection with open appendectomy after exteriorization of the appendix through the port site. Compared to the conventional three-port approach, this technique provides an alternative with excellent cosmetic outcome. We developed a safe and effective technique to perform an intracorporeal single port appendectomy, using the same laparoscope employed in the extracorporeal procedure. Retrospective review of 71 consecutively performed intracorporeal single port appendectomies and 30 conventional three-port appendectomies in children 6 to 17 years of age...
December 20, 2016: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/27993987/the-mammal-specific-pdx1-area-ii-enhancer-has-multiple-essential-functions-in-early-endocrine-cell-specification-and-postnatal-%C3%AE-cell-maturation
#10
Yu-Ping Yang, Mark A Magnuson, Roland Stein, Christopher V E Wright
The transcription factor Pdx1 is required for multiple aspects of pancreatic organogenesis. It remains unclear to what extent Pdx1 expression and function depend upon trans-activation through 5' conserved cis-regulatory regions and, in particular, whether the mammal-specific Area II (-2139 to -1958 bp) affects minor or major aspects of organogenesis. We show that Area II is a primary effector of endocrine-selective transcription in epithelial multipotent cells, nascent endocrine progenitors, and differentiating and mature β cells in vivo Pdx1(ΔAREAII/-) mice exhibit a massive reduction in endocrine progenitor cells and progeny hormone-producing cells, indicating that Area II activity is fundamental to mounting an effective endocrine lineage-specification program within the multipotent cell population...
January 15, 2017: Development
https://www.readbyqxmd.com/read/27986210/emerging-technologies-and-techniques-in-radiation-therapy
#11
REVIEW
William J Magnuson, Amandeep Mahal, James B Yu
The past decade has brought an improved ability to precisely target and deliver radiation as well as other focal prostate-directed therapy. Stereotactic body radiotherapy (SBRT), proton beam radiation, high-dose-rate (HDR) brachytherapy, as well as nonradiotherapy treatments such as cryoablation and high-intensity focused ultrasound are several therapeutic modalities that have been investigated for the treatment of prostate cancer in an attempt to reduce toxicity while improving cancer control. However, high-risk prostate cancer requires a comprehensive treatment of the prostate as well as areas at risk for cancer spread...
January 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/27976431/inhibition-of-adipose-tissue-ppar%C3%AE-prevents-increased-adipocyte-expansion-after-lipectomy-and-exacerbates-a-glucose-intolerant-phenotype
#12
A D Booth, A M Magnuson, K A Cox-York, Y Wei, D Wang, M J Pagliassotti, M T Foster
OBJECTIVES: Adipose tissue plays a fundamental role in glucose homeostasis. For example, fat removal (lipectomy, LipX) in lean mice, resulting in a compensatory 50% increase in total fat mass, is associated with significant improvement in glucose tolerance. This study was designed to further examine the link between fat removal, adipose tissue compensation and glucose homeostasis using a peroxisome proliferator-activated receptor γ (PPAR γ; activator of adipogenesis) knockout mouse...
December 15, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27972096/ticagrelor-treatment-for-prevention-of-cardiovascular-events-in-high-risk-post-myocardial-infarction-patients-cost-effectiveness-analysis-using-evidence-from-the-pegasus-timi-54-trial
#13
P Moore, A Briggs, A Davies, M Sculpher, K Kun, E A Magnuson, D J Cohen, C Mellstrom
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972089/cost-effectiveness-of-ticagrelor-60-mg-in-high-risk-post-mi-patients-from-a-dutch-societal-perspective
#14
P Moore, A Briggs, A Davies, M Sculpher, J Williams, E Fenwick, G van de Wetering, E A Magnuson, D J Cohen, H G van Haalen, C Mellstrom
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27969687/tct-34-effect-of-sapien-3-transcatheter-valve-implant-on-health-status-in-patients-with-severe-aortic-stenosis-at-intermediate-surgical-risk-results-from-the-partner-s3i-trial
#15
Suzanne Baron, Maria Alu, Vinod Thourani, Susheel Kodali, Suzanne Arnold, Khaja Chinnakondepali, Elizabeth Magnuson, Kaijun Wang, Augusto Pichard, Vasilis Babaliaros, Isaac George, D Craig Miller, E Murat Tuzcu, Kevin Greason, Howard Herrmann, Craig Smith, Martin Leon, David Cohen
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27903191/cost-effectiveness-of-stereotactic-radiosurgery-versus-whole-brain-radiation-therapy-for-up-to-10-brain-metastases
#16
Nataniel H Lester-Coll, Arie P Dosoretz, William J Magnuson, Maxwell S Laurans, Veronica L Chiang, James B Yu
OBJECTIVE The JLGK0901 study found that stereotactic radiosurgery (SRS) is a safe and effective treatment option for treating up to 10 brain metastases. The purpose of this study is to determine the cost-effectiveness of treating up to 10 brain metastases with SRS, whole-brain radiation therapy (WBRT), or SRS and immediate WBRT (SRS+WBRT). METHODS A Markov model was developed to evaluate the cost effectiveness of SRS, WBRT, and SRS+WBRT in patients with 1 or 2-10 brain metastases. Transition probabilities were derived from the JLGK0901 study and modified according to the recurrence rates observed in the Radiation Therapy Oncology Group (RTOG) 9508 and European Organization for Research and Treatment of Cancer (EORTC) 22952-26001 studies to simulate the outcomes for patients who receive WBRT...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27881032/clinical-implications-of-assay-specific-differences-in-f-calprotectin-when-monitoring-inflammatory-bowel-disease-activity-over-time
#17
Karin Amcoff, Mats Stridsberg, Maria Lampinen, Anders Magnuson, Marie Carlson, Jonas Halfvarson
OBJECTIVE: With several faecal calprotectin (FC) assays on the market, it has been difficult to define a uniform threshold for discriminating between remission and active disease in patients with inflammatory bowel disease (IBD). We aimed to compare the results of different FC-assays in IBD patients, followed over time. MATERIAL AND METHODS: IBD patients provided faecal samples and reported clinical activity every third month prospectively over a two year period...
March 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27865363/pathology-based-staging-for-hpv-positive-squamous-carcinoma-of-the-oropharynx
#18
B H Haughey, P Sinha, D Kallogjeri, R L Goldberg, J S Lewis, J F Piccirillo, R S Jackson, E J Moore, M Brandwein-Gensler, S J Magnuson, W R Carroll, T M Jones, M D Wilkie, A Lau, N S Upile, Jon Sheard, J Lancaster, S Tandon, M Robinson, D Husband, I Ganly, J P Shah, D M Brizel, B O'Sullivan, J A Ridge, W M Lydiatt
OBJECTIVE: The rapid worldwide rise in incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has generated studies confirming this disease as an entity distinct from traditional OPSCC. Based on pathology, surgical studies have revealed prognosticators specific to HPV-positive OPSCC. The current AJCC/UICC staging and pathologic nodal (pN)-classification do not differentiate for survival, demonstrating the need for new, HPV-specific OPSCC staging...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27864380/setd5-is-essential-for-mammalian-development-and-the-co-transcriptional-regulation-of-histone-acetylation
#19
Anna B Osipovich, Rama Gangula, Pedro G Vianna, Mark A Magnuson
SET domain-containing proteins play a vital role in regulating gene expression during development through modifications in chromatin structure. Here we show that SET domain-containing 5 (Setd5) is divergently transcribed with Gt(ROSA26)Sor, is necessary for mammalian development, and interacts with the PAF1 co-transcriptional complex and other proteins. Setd5-deficient mouse embryos exhibit severe defects in neural tube formation, somitogenesis and cardiac development, have aberrant vasculogenesis in embryos, yolk sacs and placentas, and die between embryonic day 10...
December 15, 2016: Development
https://www.readbyqxmd.com/read/27859534/exposure-to-ultraviolet-radiation-late-in-development-increases-the-toxicity-of-oil-to-mahi-mahi-coryphaena-hippurus-embryos
#20
Lauren E Sweet, Jason Magnuson, T Ross Garner, Matthew M Alloy, John D Stieglitz, Daniel Benetti, Martin Grosell, Aaron P Roberts
The Deepwater Horizon oil spill in 2010 overlapped with the spawning of many pelagic fish species in the Gulf of Mexico, including mahi-mahi (Coryphaena hippurus). Polycyclic aromatic hydrocarbons (PAHs) released during the spill have been shown to cause photo-induced toxicity under ultraviolet (UV) radiation. In the present study, mahi-mahi embryos were exposed to high-energy water accommodated fractions of source and naturally weathered oils for up to 48 h. The timing of co-exposure with UV radiation varied between an early development exposure for 8 h or a late development exposure for 8 h...
November 16, 2016: Environmental Toxicology and Chemistry
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