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https://www.readbyqxmd.com/read/29759501/assessment-of-atrial-fibrillation-specific-symptoms-before-and-2-years-after-atrial-fibrillation-ablation-do-patients-and-physicians-differ-in-their-perception-of-symptom-relief
#1
Anna Björkenheim, Axel Brandes, Anders Magnuson, Alexander Chemnitz, Lena Svedberg, Nils Edvardsson, Dritan Poçi
OBJECTIVES: The aim of this study was to evaluate patient-reported and physician-assessed atrial fibrillation (AF)-related symptoms after AF ablation. BACKGROUND: Success of AF ablation is usually defined as freedom from AF, although symptom relief is often patients' desire. METHODS: Symptom relief was assessed as perceived by patients using the short, validated, AF-specific symptom questionnaire AF6 and as classified by physicians using the European Heart Rhythm Association (EHRA) classification at baseline and 6, 12, and 24 months after AF ablation...
October 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29738077/the-effects-of-enriched-environment-on-the-behavioral-and-corticosterone-response-to-methamphetamine-in-adolescent-and-adult-mice
#2
Elizabeth P Baker, Elliott C Magnuson, Ashley M Dahly, Jessica A Siegel
Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long-term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments...
May 8, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29733582/dietary-supplemental-microalgal-astaxanthin-produced-dose-dependent-enrichments-and-improved-redox-status-in-tissues-of-broiler-chicks
#3
Tao Sun, Ran Yin, Andrew D Magnuson, Samar Amin Tolba, Guanchen Liu, Xingen Lei
Astaxanthin (AST) is a well-known carotenoid with high antioxidant capacity. This study was to evaluate nutritional and metabolic effects of microalgal AST in diets for broiler chicks under heat stress. A total of 240 (day-old) Cornish male chicks were divided into 6 cages/treatment (8 chicks/cage) and fed corn-soy diet supplemented with AST from Haematococcus pluvialis at 0, 10, 20, 40, and 80 mg/kg for 6 weeks. Heat stress was employed during week 4-6. The supplementations led to dose-dependent enrichments (P < 0...
May 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29727836/fish-thermal-habitat-current-use-and-simulation-of-thermal-habitat-availability-in-lakes-of-the-argentine-patagonian-andes-under-climate-change-scenarios-rcp-4-5-and-rcp-8-5
#4
Pablo H Vigliano, Magalí M Rechencq, María V Fernández, Gustavo E Lippolt, Patricio J Macchi
Habitat use in relation to the thermal habitat availability and food source as a forcing factor on habitat selection and use of Percichthys trucha (Creole perch), Oncorhynchus mykiss (rainbow trout), Salmo trutta (brown trout) and Salvelinus fontinalis (brook trout) were determined as well as future potential thermal habitat availability for these species under climate change scenarios Representative Concentration Pathways 4.5 and 8.5. This study was conducted in three interconnected lakes of Northern Patagonia (Moreno Lake system)...
May 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29724827/draft-genome-sequence-of-aspergillus-oryzae-atcc-12892
#5
Shuang Deng, Kyle R Pomraning, Pavlo Bohutskyi, Jon K Magnuson
The draft genome sequence of Aspergillus oryzae ATCC 12892 is presented here. A. oryzae produces 3-nitropropionic acid, which has been investigated with regard to understanding the biosynthesis of nitroorganic compounds.
May 3, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29713952/tisk-1-0-an-easy-to-use-python-implementation-of-the-time-invariant-string-kernel-model-of-spoken-word-recognition
#6
Heejo You, James S Magnuson
This article describes a new Python distribution of TISK, the time-invariant string kernel model of spoken word recognition (Hannagan et al. in Frontiers in Psychology, 4, 563, 2013). TISK is an interactive-activation model similar to the TRACE model (McClelland & Elman in Cognitive Psychology, 18, 1-86, 1986), but TISK replaces most of TRACE's reduplicated, time-specific nodes with theoretically motivated time-invariant, open-diphone nodes. We discuss the utility of computational models as theory development tools, the relative merits of TISK as compared to other models, and the ways in which researchers might use this implementation to guide their own research and theory development...
April 30, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29678347/the-incidence-and-risk-factors-associated-with-developing-symptoms-of-hypoglycemia-after-bariatric-surgery
#7
Clare J Lee, Todd T Brown, Michael Schweitzer, Thomas Magnuson, Jeanne M Clark
BACKGROUND: Hypoglycemia after bariatric surgery is an increasingly recognized metabolic complication associated with exaggerated secretion of insulin and gut hormones. OBJECTIVE: We sought to determine the incidence of hypoglycemic symptoms (hypo-sx) after bariatric surgery and characteristics of those affected compared with those unaffected. SETTING: University hospital. METHODS: We collected retrospective survey data from the patients who underwent bariatric surgery at a single center...
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29676963/pictorial-review-of-digital-radiography-artifacts
#8
Alisa I Walz-Flannigan, Kimberly J Brossoit, Dayne J Magnuson, Beth A Schueler
Visual familiarity with the variety of digital radiographic artifacts is needed to identify, resolve, or prevent image artifacts from creating issues with patient imaging. Because the mechanism for image creation is different between flat-panel detectors and computed radiography, the causes and appearances of some artifacts can be unique to these different modalities. Examples are provided of artifacts that were found on clinical images or during quality control testing with flat-panel detectors. The examples are meant to serve as learning tools for future identification and troubleshooting of artifacts and as a reminder for steps that can be taken for prevention...
April 20, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29672864/menin-regulates-the-serine-biosynthetic-pathway-in-ewing-sarcoma
#9
Laurie K Svoboda, Selina Shiqing K Teh, Sudha Sud, Samuel Kerk, Aaron Zebolsky, Sydney Treichel, Dafydd Thomas, Christopher J Halbrook, Ho-Joon Lee, Daniel Kremer, Li Zhang, Szymon Klossowski, Armand R Bankhead, Brian Magnuson, Mats Ljungman, Tomasz Cierpicki, Jolanta Grembecka, Costas A Lyssiotis, Elizabeth R Lawlor
Developmental transcription programs are epigenetically regulated by multi-protein complexes, including the menin- and MLL-containing trithorax (TrxG) complexes, which promote gene transcription by depositing the H3K4me3 activating mark at target gene promoters. We recently reported that in Ewing sarcoma, MLL1 (lysine methyltransferase 2A, KMT2A) and menin are overexpressed and function as oncogenes. Small molecule inhibition of the menin-MLL interaction leads to loss of menin and MLL1 protein expression and to inhibition of growth and tumorigenicity...
April 19, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29670489/progress-toward-precise-genetic-repair-in-neurons
#10
COMMENT
Thomas J Richner, Esther Krook-Magnuson
No abstract text is available yet for this article.
March 2018: Epilepsy Currents
https://www.readbyqxmd.com/read/29666593/interaction-in-spoken-word-recognition-models-feedback-helps
#11
James S Magnuson, Daniel Mirman, Sahil Luthra, Ted Strauss, Harlan D Harris
Human perception, cognition, and action requires fast integration of bottom-up signals with top-down knowledge and context. A key theoretical perspective in cognitive science is the interactive activation hypothesis: forward and backward flow in bidirectionally connected neural networks allows humans and other biological systems to approximate optimal integration of bottom-up and top-down information under real-world constraints. An alternative view is that online feedback is neither necessary nor helpful; purely feed forward alternatives can be constructed for any feedback system, and online feedback could not improve processing and would preclude veridical perception...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29656931/synaptotagmin-4-regulates-pancreatic-%C3%AE-cell-maturation-by-modulating-the-ca-2-sensitivity-of-insulin-secretion-vesicles
#12
Chen Huang, Emily M Walker, Prasanna K Dadi, Ruiying Hu, Yanwen Xu, Wenjian Zhang, Tiziana Sanavia, Jisoo Mun, Jennifer Liu, Gopika G Nair, Hwee Yim Angeline Tan, Sui Wang, Mark A Magnuson, Christian J Stoeckert, Matthias Hebrok, Maureen Gannon, Weiping Han, Roland Stein, David A Jacobson, Guoqiang Gu
Islet β cells from newborn mammals exhibit high basal insulin secretion and poor glucose-stimulated insulin secretion (GSIS). Here we show that β cells of newborns secrete more insulin than adults in response to similar intracellular Ca2+ concentrations, suggesting differences in the Ca2+ sensitivity of insulin secretion. Synaptotagmin 4 (Syt4), a non-Ca2+ binding paralog of the β cell Ca2+ sensor Syt7, increased by ∼8-fold during β cell maturation. Syt4 ablation increased basal insulin secretion and compromised GSIS...
April 12, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29595874/temporal-analysis-of-cardiovascular-control-and-function-following-incomplete-t3-and-t10-spinal-cord-injury-in-rodents
#13
Kathryn A Harman, Gregory States, Abigail Wade, Chad Stepp, Grace Wainwright, Kathryn DeVeau, Nicholas King, Alice Shum-Siu, David S K Magnuson
Spinal cord injury (SCI) is a devastating condition that results in whole-body dysfunction, notably cardiovascular (CV) disruption and disease. Injury-induced destruction of autonomic pathways in conjunction with a progressive decline in physical fitness contribute to the poor CV status of SCI individuals. Despite the wide use of exercise training as a therapeutic option to reduce CV dysfunction, little is known about the acute hemodynamic responses to the exercise itself. We investigated CV responses to an exercise challenge (swimming) following both high and low thoracic contusion to determine if the CV system is able to respond appropriately to the challenge of swimming...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29556889/endoscopic-management-of-recalcitrant-marginal-ulcers-by-covering-the-ulcer-bed
#14
Sindhu Barola, Lea Fayad, Christine Hill, Thomas Magnuson, Michael Schweitzer, Vikesh Singh, Yen-I Chen, Saowanee Ngamruengphong, Mouen A Khashab, Anthony N Kalloo, Vivek Kumbhari
BACKGROUND: Management options for marginal ulcers (MU) vary from medical therapy to revision surgery. Medical therapy is often ineffective and revision surgery is associated with a high morbidity and possible recurrence. AIMS: To evaluate technical feasibility, efficacy, and safety of endoscopic management of MU by covering the ulcer bed using oversewing and/or deploying a fully covered self-expandable metallic stent (FCSEMS). METHODS: Medical records of consecutive patients who underwent endoscopic suturing and/or FCSEMS deployment for recalcitrant MU between August 2016 and June 2017 at a single academic center were reviewed...
March 19, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29523669/community-oncologists-decision-making-for-treatment-of-older-patients-with-cancer
#15
Supriya G Mohile, Allison Magnuson, Chintan Pandya, Carla Velarde, Paul Duberstein, Arti Hurria, Kah Poh Loh, Megan Wells, Sandy Plumb, Nikesha Gilmore, Marie Flannery, Marsha Wittink, Ronald Epstein, Charles E Heckler, Michelle Janelsins, Karen Mustian, Judith O Hopkins, Jane Liu, Srihari Peri, William Dale
Background: This study's objectives were to describe community oncologists' beliefs about and confidence with geriatric care and to determine whether geriatric-relevant information influences cancer treatment decisions. Methods: Community oncologists were recruited to participate in 2 multisite geriatric oncology trials. Participants shared their beliefs about and confidence in caring for older adults. They were also asked to make a first-line chemotherapy recommendation (combination vs single-agent vs no chemotherapy) for a hypothetical vignette of an older patient with advanced pancreatic cancer...
March 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29521013/long-term-clinical-and-quality-of-life-outcomes-after-stenting-of-femoropopliteal-artery-stenosis-3-year-results-from-the-stroll-study
#16
Matthew C Bunte, David J Cohen, Michael R Jaff, William A Gray, Elizabeth A Magnuson, Haiyan Li, Andrew Feiring, Marco Cioppi, Robert Hibbard, Bruce Gray, Yazan Khatib, David Jessup, Roberto Patarca, Jing Du, Hans-Peter Stoll, Joe Massaro, David M Safley
OBJECTIVES: To evaluate the clinical and health status outcomes of patients undergoing superficial femoral artery (SFA) revascularization using the Shape Memory Alloy Recoverable Technology (S.M.A.R.T.®) nitinol self-expanding stent through 3 years of follow-up. BACKGROUND: Limited long-term data are available describing the durability of benefits after femoropopliteal revascularization. METHODS: In a multicenter, prospective, core-lab adjudicated study, 250 subjects with de novo or restenotic femoropopliteal arterial lesions were treated with the S...
March 9, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29506921/elucidating-the-associations-between-sleep-disturbance-and-depression-fatigue-and-pain-in-older-adults-with-cancer
#17
Kah Poh Loh, Jason Zittel, Sindhuja Kadambi, Chintan Pandya, Huiwen Xu, Marie Flannery, Allison Magnuson, Javier Bautista, Colin McHugh, Karen Mustian, William Dale, Paul Duberstein, Supriya G Mohile
OBJECTIVES: Sleep disturbance is prevalent and often coexists with depression, fatigue, and pain in the cancer population. The aim of this study was to describe the prevalence of sleep disturbance with co-existing depression, fatigue, and pain in older patients with cancer. We also examined the associations of several socio-demographic and clinical variables with sleep disturbance. METHODS: This cross-sectional study consisted of 389 older patients with solid and hematologic malignancies who were referred to the Specialized Oncology Care & Research in the Elderly (SOCARE) clinics at the Universities of Rochester and Chicago between May 2011 and October 2015 and completed a sleep and geriatric assessment (that inquires about fatigue, pain, and depression)...
March 2, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29501838/adipose-tissue-extrinsic-factor-obesity-induced-inflammation-and-the-role-of-the-visceral-lymph-node
#18
REVIEW
Aaron M Magnuson, Josephine K Fouts, Daniel P Regan, Andrea D Booth, Steve W Dow, Michelle T Foster
Obesity-related adverse health consequences occur predominately in individuals with upper body fat distribution commonly associated with increased central adiposity. Visceral adipose tissue accumulation is described to be the greatest driver of obesity-induced inflammation, however evidence also supports that the intestines fundamentally contribute to the development of obesity-induced metabolic disease. The visceral adipose depot shares the same vasculature and lymph drainage as the small intestine. We hypothesize that the visceral lymph node, which drains adipose tissue and the gastrointestinal tract, is central to the exacerbation of systemic pro-inflammation...
June 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29478027/patient-reported-outcomes-in-relation-to-continuously-monitored-rhythm-before-and-during-2-years-after-atrial-fibrillation-ablation-using-a-disease-specific-and-a-generic-instrument
#19
Anna Björkenheim, Axel Brandes, Anders Magnuson, Alexander Chemnitz, Nils Edvardsson, Dritan Poçi
BACKGROUND: Atrial fibrillation (AF) ablation improves patient-reported outcomes, irrespective of mode of intermittent rhythm monitoring. We evaluated the use of an AF-specific and a generic patient-reported outcomes instrument during continuous rhythm monitoring 2 years after AF ablation. METHODS AND RESULTS: Fifty-four patients completed the generic 36-Item Short-Form Health Survey and the AF-specific AF6 questionnaires before and 6, 12, and 24 months after AF ablation...
February 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29466395/dynamics-of-monocytic-hla-dr-expression-differs-between-bacterial-etiologies-during-the-course-of-bloodstream-infection
#20
Sara Cajander, Gunlög Rasmussen, Elisabet Tina, Anders Magnuson, Bo Söderquist, Jan Källman, Kristoffer Strålin
OBJECTIVE: In the pathogenesis of sepsis, activation of both pro- and anti-inflammatory responses are key components, but knowledge is lacking on the association between bacterial etiology and development of dysregulated responses with sustained immunosuppression. The aim of this study was to evaluate how the immunosupression marker HLA-DR on monocytes (mHLA-DR) is associated with bacterial etiology and markers of inflammation during the clinical trajectory of bloodstream infection (BSI)...
2018: PloS One
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