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https://www.readbyqxmd.com/read/28331472/the-gate-and-the-source-the-dentate-gyrus-takes-central-stage-in-temporal-lobe-epilepsy
#1
Esther Krook-Magnuson
No abstract text is available yet for this article.
January 2017: Epilepsy Currents
https://www.readbyqxmd.com/read/28320440/ecological-niche-modeling-of-rabies-in-the-changing-arctic-of-alaska
#2
Falk Huettmann, Emily Elizabeth Magnuson, Karsten Hueffer
BACKGROUND: Rabies is a disease of global significance including in the circumpolar Arctic. In Alaska enzootic rabies persist in northern and western coastal areas. Only sporadic cases have occurred in areas outside of the regions considered enzootic for the virus, such as the interior of the state and urbanized regions. RESULTS: Here we examine the distribution of diagnosed rabies cases in Alaska, explicit in space and time. We use a geographic information system (GIS), 20 environmental data layers and provide a quantitative non-parsimonious estimate of the predicted ecological niche, based on data mining, machine learning and open access data...
March 20, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28288544/dynamic-range-of-motion-hindlimb-stretching-disrupts-locomotor-function-in-rats-with-moderate-subacute-spinal-cord-injuries
#3
Anastasia Valerievna Keller, Kathlene Marie Rees, Daniella Christina Prince, Johnny R Morehouse, Alice Shum-Siu, David Sk Magnuson
Joint contractures and spasticity are two common secondary complications of a severe spinal cord injury (SCI) that can significantly reduce quality of life and stretching is one of the top strategies for rehabilitation of these complications. We have previously shown that a daily static stretching protocol administered to rats at either acute or chronic time points after a moderate or moderate-severe T10 SCI significantly disrupts their hindlimb locomotor function. The objective of the current study was to examine the effects of dynamic range of motion stretching on the locomotor function of rats with SCI as an alternative to static stretching...
March 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28258664/surgical-and-not-analgesic-technique-affects-postoperative-inflammation-following-colorectal-cancer-surgery-a-prospective-randomized-study
#4
W Siekmann, C Eintrei, A Magnuson, A Sjölander, P Matthiessen, P Myrelid, A Gupta
AIM: Epidural analgesia reduces the surgical stress response. However, its effect on pro- and anti-inflammatory cytokines in the genesis of inflammation following major abdominal surgery remains unclear. Our main objective was to elucidate whether perioperative epidural analgesia prevents the inflammatory response following colorectal cancer surgery. METHODS: 96 patients scheduled for open or laparoscopic surgery were randomized to epidural analgesia (group E) or patient controlled intravenous analgesia (group P)...
March 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28256581/transcriptional-and-post-transcriptional-regulation-of-the-ionizing-radiation-response-by-atm-and-p53
#5
Ishwarya Venkata Narayanan, Michelle T Paulsen, Karan Bedi, Nathan Berg, Emily A Ljungman, Sofia Francia, Artur Veloso, Brian Magnuson, Fabrizio d'Adda di Fagagna, Thomas E Wilson, Mats Ljungman
In response to ionizing radiation (IR), cells activate a DNA damage response (DDR) pathway to re-program gene expression. Previous studies using total cellular RNA analyses have shown that the stress kinase ATM and the transcription factor p53 are integral components required for induction of IR-induced gene expression. These studies did not distinguish between changes in RNA synthesis and RNA turnover and did not address the role of enhancer elements in DDR-mediated transcriptional regulation. To determine the contribution of synthesis and degradation of RNA and monitor the activity of enhancer elements following exposure to IR, we used the recently developed Bru-seq, BruChase-seq and BruUV-seq techniques...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254491/ezh1-in-germ-cells-safeguards-the-function-of-prc2-during-spermatogenesis
#6
Weipeng Mu, Joshua Starmer, Yoichiro Shibata, Della Yee, Terry Magnuson
We previously reported the requirement of Polycomb Repressive Complex 2 (PRC2) for spermatogenesis through transcriptional repression of somatic genes and meiosis-specific genes. To characterize how PRC2's two methyltransferase subunits, EZH1 and EZH2, regulate histone H3 lysine 27 (H3K27) methylation during germ cell development, we generated mouse models with a germline ablation of EZH1 and/or EHZ2. Only the combined loss of EZH1 and EZH2 caused a depletion of global H3K27me3 marks and meiotic arrest in spermatocytes...
February 27, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28248708/early-perioperative-immunological-effects-of-anaesthesia-and-analgesia-in-patients-undergoing-prostate-cancer-surgery-a-randomised-pilot-study
#7
Federica Fant, Elisabet Tina, Sven Olof Andersson, Anders Magnuson, Elisabeth Hultgren-Hörnquist, Anil Gupta
No abstract text is available yet for this article.
April 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28247322/endoscopic-suturing-for-massively-bleeding-marginal-ulcer-10%C3%A2-days-post-roux-en-y-gastric-bypass
#8
Sindhu Barola, Thomas Magnuson, Michael Schweitzer, Yen-I Chen, Saowanee Ngamruengphong, Mouen A Khashab, Vivek Kumbhari
BACKGROUND: Marginal ulceration post Roux-en-Y gastric bypass (RYGB) with associated bleeding, although infrequently encountered, can be challenging to treat. Flexible endoscopic therapy is preferred over surgery due to its minimally invasive nature. Bleeding ulcers have traditionally been treated endoscopically by injecting epinephrine, bipolar hemostasis, or clips. Here, we describe our treatment with endoscopic suturing for a massively bleeding marginal ulcer after RYGB. METHODS: A 56-year-old female 10 days post RYGB underwent her fourth endoscopy for investigation and management of hematemesis and was found to have a large bleeding anastomotic ulcer...
February 28, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28244987/capzimin-is-a-potent-and-specific-inhibitor-of-proteasome-isopeptidase-rpn11
#9
Jing Li, Tanya Yakushi, Francesco Parlati, Andrew L Mackinnon, Christian Perez, Yuyong Ma, Kyle P Carter, Sharon Colayco, Gavin Magnuson, Brock Brown, Kevin Nguyen, Stefan Vasile, Eigo Suyama, Layton H Smith, Eduard Sergienko, Anthony B Pinkerton, Thomas D Y Chung, Amy E Palmer, Ian Pass, Sonja Hess, Seth M Cohen, Raymond J Deshaies
The proteasome is a vital cellular machine that maintains protein homeostasis, which is of particular importance in multiple myeloma and possibly other cancers. Targeting of proteasome 20S peptidase activity with bortezomib and carfilzomib has been widely used to treat myeloma. However, not all patients respond to these compounds, and those who do eventually suffer relapse. Therefore, there is an urgent and unmet need to develop new drugs that target proteostasis through different mechanisms. We identified quinoline-8-thiol (8TQ) as a first-in-class inhibitor of the proteasome 19S subunit Rpn11...
February 28, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28236826/advanced-oxidation-of-tartrazine-and-brilliant-blue-with-pulsed-ultraviolet-light-emitting-diodes
#10
Robert Scott, Patrick Mudimbi, Michael E Miller, Matthew Magnuson, Stuart Willison, Rebecca Phillips, Willie F Harper
  This study investigated the effect of ultraviolet light-emitting diodes (UVLEDs) coupled with hydrogen peroxide as an advanced oxidation process (AOP) for the degradation of two test chemicals. Brilliant Blue FCF consistently exhibited greater degradation than tartrazine, with 83% degradation after 300 minutes at the 100% duty cycle compared with only 17% degradation of tartrazine under the same conditions. These differences are attributable to the structural properties of the compounds. Duty cycle was positively correlated with the first-order rate constants (k) for both chemicals but, interestingly, negatively correlated with the normalized first-order rate constants (k/duty cycle)...
January 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28223291/ctrp7-deletion-attenuates-obesity-linked-glucose-intolerance-adipose-tissue-inflammation-and-hepatic-stress
#11
Pia S Petersen, Xia Lei, Risa M Wolf, Susana Rodriguez, Stefanie Y Tan, Hannah C Little, Michael A Schweitzer, Thomas H Magnuson, Kimberley E Steele, G William Wong
Chronic low-grade inflammation and cellular stress are important contributors to obesity-linked metabolic dysfunction. Here, we uncover an immune-metabolic role for C1q/TNF-related protein 7 (CTRP7), a secretory protein of the C1q family with previously unknown function. In obese humans, circulating CTRP7 levels were markedly elevated and positively correlated with BMI, glucose, insulin, insulin resistance index, hemoglobin A1c, and triglyceride levels. Expression of CTRP7 in liver was also significantly upregulated in obese humans and positively correlated with gluconeogenic genes...
February 21, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28211872/rictor-mtorc2-deficiency-enhances-keratinocyte-stress-tolerance-via-mitohormesis
#12
Beatrice Tassone, Stefania Saoncella, Francesco Neri, Ugo Ala, Davide Brusa, Mark A Magnuson, Paolo Provero, Salvatore Oliviero, Chiara Riganti, Enzo Calautti
How metabolic pathways required for epidermal tissue growth and remodeling influence the ability of keratinocytes to survive stressful conditions is still largely unknown. The mechanistic target of rapamycin complex 2 (mTORC2) regulates growth and metabolism of several tissues, but its functions in epidermal cells are poorly defined. Rictor is an adaptor protein essential for mTORC2 activity. To explore the roles of mTORC2 in the epidermis, we have conditionally deleted rictor in mice via K14-Cre-mediated homologous recombination and found that its deficiency causes moderate tissue hypoplasia, reduced keratinocyte proliferation and attenuated hyperplastic response to TPA...
February 17, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28162420/-196-a-proof-of-concept-for-short-forms-of-the-screener-and-opioid-assessment-for-patients-with-pain-revised-soapp-r
#13
M Finkelman, N Smits, R Kulich, K Zacharoff, B Magnuson, H Chang, J Dong, S Butler
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28159836/c-myc-downregulation-is-required-for-preacinar-to-acinar-maturation-and-pancreatic-homeostasis
#14
Victor J Sánchez-Arévalo Lobo, Luis César Fernández, Enrique Carrillo-de-Santa-Pau, Laia Richart, Isidoro Cobo, Jaroslaw Cendrowski, Ulisses Moreno, Natalia Del Pozo, Diego Megías, Bernardette Bréant, Christopher V Wright, Mark Magnuson, Francisco X Real
BACKGROUND AND AIMS: c-Myc is highly expressed in pancreatic multipotent progenitor cells (MPC) and in pancreatic cancer. The transition from MPC to unipotent acinar progenitors is associated with c-Myc downregulation; a role for c-Myc in this process, and its possible relationship to a role in cancer, has not been established. DESIGN: Using coimmunoprecipitation assays, we demonstrate that c-Myc and Ptf1a interact. Using reverse transcriptase qPCR, western blot and immunofluorescence, we show the erosion of the acinar programme...
February 3, 2017: Gut
https://www.readbyqxmd.com/read/28151564/axonal-sprouting-in-commissurally-projecting-parvalbumin-expressing-interneurons
#15
Zoé Christenson Wick, Caara H Leintz, Casey Xamonthiene, Bin H Huang, Esther Krook-Magnuson
Previous research has shown that in vivo on-demand optogenetic stimulation of inhibitory interneurons expressing parvalbumin (PV) is sufficient to suppress seizures in a mouse model of temporal lobe epilepsy (TLE). Surprisingly, this intervention was capable of suppressing seizures when PV-expressing interneurons were stimulated ipsilateral or contralateral to the presumed seizure focus, raising the possibility of commissural inhibition in TLE. There are mixed reports regarding commissural PV interneuron projections in the healthy hippocampus, and it was previously unknown whether these connections would be maintained or modified following the network reorganization associated with TLE...
February 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28126601/rapid-screening-for-mycobacterium-tuberculosis-complex-in-clinical-elephant-trunk-wash-samples
#16
Roberta J Magnuson, Lyndsey M Linke, Ramiro Isaza, Mo D Salman
Mycobacterium tuberculosis can infect and be transmitted between elephants and humans. In elephants, the 'gold standard' reference test for detection of tuberculosis is culture, which takes a minimum of eight weeks for results and has limited sensitivity. A screening test that is rapid, easily implemented, and accurate is needed to aid in diagnosis of tuberculosis in elephants. Ninety-nine clinical trunk wash samples obtained from 33 elephants were utilized to validate three molecular extraction techniques followed by a polymerase chain reaction for detection of M...
January 3, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28116196/a-rare-presentation-of-isolated-cns-posttransplantation-lymphoproliferative-disorder
#17
Jaime Morris, Casey Smith, Andrew Streicher, Allison Magnuson, Susan Newman, Robert Bertoli
Posttransplantation lymphoproliferative disorder (PTLD) is a recognized and extremely morbid complication of solid organ transplantation, but central nervous system involvement, particularly in isolation, is rare. There are no standardized treatment strategies for PTLD, though commonly used strategies include reduction of immunosuppression, chemotherapy, rituximab, radiation, and surgery. We present a case of an unusual morphologic variant of primary central nervous system PTLD with successful response to rituximab and cranial radiation...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28113019/management-of-brain-metastases-in-tyrosine-kinase-inhibitor-na%C3%A3-ve-epidermal-growth-factor-receptor-mutant-non-small-cell-lung-cancer-a-retrospective-multi-institutional-analysis
#18
William J Magnuson, Nataniel H Lester-Coll, Abraham J Wu, T Jonathan Yang, Natalie A Lockney, Naamit K Gerber, Kathryn Beal, Arya Amini, Tejas Patil, Brian D Kavanagh, D Ross Camidge, Steven E Braunstein, Lauren C Boreta, Suresh K Balasubramanian, Manmeet S Ahluwalia, Niteshkumar G Rana, Albert Attia, Scott N Gettinger, Joseph N Contessa, James B Yu, Veronica L Chiang
Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for brain metastases in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). This multi-institutional analysis sought to determine the optimal management of patients with EGFR-mutant NSCLC who develop brain metastases and have not received EGFR-TKI. Materials and Methods A total of 351 patients from six institutions with EGFR-mutant NSCLC developed brain metastases and met inclusion criteria for the study...
January 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28087936/fungal-ligninolytic-enzymes-and-their-applications
#19
Miia R Mäkelä, Erin L Bredeweg, Jon K Magnuson, Scott E Baker, Ronald P de Vries, Kristiina Hildén
The global push toward an efficient and economical biobased economy has driven research to develop more cost-effective applications for the entirety of plant biomass, including lignocellulosic crops. As discussed elsewhere (Karlsson M, Atanasova L, Funck Jensen D, Zeilinger S, in Heitman J et al. [ed], Tuberculosis and the Tubercle Bacillus, 2nd ed, in press), significant progress has been made in the use of polysaccharide fractions from lignocellulose, cellulose, and various hemicellulose types. However, developing processes for use of the lignin fraction has been more challenging...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28065654/challenging-cardiac-function-post-spinal-cord-injury-with-dobutamine
#20
Kathryn M DeVeau, Emily K Martin, Nicholas T King, Alice Shum-Siu, Bradley B Keller, Christopher R West, David S K Magnuson
There is general consensus that spinal cord injuries (SCI) above T6 result in altered sympathetic control of the heart, which negatively influences cardiac structure and function. To by-pass disrupted circuitry and investigate cardiac responses under enhanced sympathetic activity we utilized dobutamine (DOB) stress echocardiography. Animals were divided into a T2, 25g-cm contusive SCI (SCI) or an uninjured control (CON) group. Echocardiography was performed pre-SCI and at 1, 2 and 6weeks post-SCI. Increasing doses of DOB (5, 10 & 20μg/min/kg) were infused intravenously pre-SCI and at 1 and 6weeks post-SCI...
December 23, 2016: Autonomic Neuroscience: Basic & Clinical
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